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Chee-Leok Goh, Sai Yee Chuah, Steven Tien, Guan Thng, María Alejandra Vitale, Arancha Delgado-Rubin
Introduction: Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern Polypodium leucotomos (PLE), Fernblock® (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. Methods: Forty healthy adult patients with clinical diagnoses of melasma who were receiving treatment with topical 4% hydroquinone cream and sunscreen with a sun protection factor (SPF) of 50+ were recruited for inclusion in this study from the National Skin Centre in Singapore...
March 2018: Journal of Clinical and Aesthetic Dermatology
Astrid S Holzer, Pavla Bartošová-Sojková, Ana Born-Torrijos, Alena Lövy, Ashlie Hartigan, Ivan Fiala
The relationships between parasites and their hosts are intimate, dynamic and complex; the evolution of one is inevitably linked to the other. Despite multiple origins of parasitism in the Cnidaria, only parasites belonging to the Myxozoa are characterized by a complex life cycle, alternating between fish and invertebrate hosts, as well as by high species diversity. This inspired us to examine the history of adaptive radiations in myxozoans and their hosts by determining the degree of congruence between their phylogenies and by timing the emergence of myxozoan lineages in relation to their hosts...
March 24, 2018: Molecular Ecology
Carolina Sánchez-Rodríguez, Keyliz R Peraza Cruces, Laura Rodrigáñez Riesco, José Antonio García-Vela, Ricardo Sanz-Fernández
BACKGROUND: Recurrent tonsillitis might reduce the immunological capability of fighting against the infection of tonsil tissue. Polypodium leucotomos (Anapsos) immunomodulating effect has been subject of research in the last years. The aim of this research is to test the in vitro immunomodulating capacity of Anapsos in a child palatine tonsil explants model. METHODS: Palatine tonsils explants of children undergoing amigdalectomy were stimulated with mononuclear cells obtained from their own blood by density gradient centrifugation...
April 2018: International Journal of Pediatric Otorhinolaryngology
C M Batista, A V F Alves, L A Queiroz, B S Lima, R N P Filho, A A S Araújo, R L C de Albuquerque Júnior, J C Cardoso
The negative effects triggered by ultraviolet radiation, such as premature aging and carcinogenesis, have motivated several studies on photoprotection. Recent strategies for photoprotection have included the incorporation of natural antioxidant and anti-inflammatory compounds, such as flavonoids, into sunscreens and the oral administration of natural antioxidant extracts. Brazilian Red propolis extract contains isoflavonoids with antioxidant and anti-inflammatory activities. Here, we investigate the photoprotective effects of orally- or topically-administered formulations containing hydroalcoholic extract of red propolis (HERP) in a rodent model...
March 2018: Journal of Photochemistry and Photobiology. B, Biology
R Speeckaert, J Dugardin, J Lambert, H Lapeere, E Verhaeghe, M M Speeckaert, N van Geel
BACKGROUND: The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of oxidative stress pathway in vitiligo is a popular although controversial research topic. OBJECTIVE: To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role of antioxidants. METHODS: We conducted a systematic search of the existing literature on the aberrancies of the oxidative stress pathway in vitiligo...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Timothy S Murbach, Róbert Glávits, Gábor Hirka, John R Endres, Amy E Clewell, Ilona Pasics Szakonyiné
Fernblock(®) is a standardized commercial aqueous extraction of the leaves of the tropical fern Polypodium leucotomos promoted as an orally active photoprotective substance. In a previous battery of toxicological tests on Fernblock(®), no genotoxicy was observed and no oral toxicity was observed up to 1200 mg/kg bw/day. The current study was conducted in Hsd.Han Wistar rats using doses of 0, 2000, 3500, and 5000 mg/kg bw/day Fernblock(®) by gavage for 28 consecutive days. No mortality or toxic effects were observed and no target organs were identified...
2017: Toxicology Reports
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
September 2017: Dermatology and Therapy
Enzo Emanuele, Marco Bertona, Marco Biagi
OBJECTIVES: Polypodium leucotomos extract is a commonly used systemic photoprotective agent. In an exploratory fashion, the current study aimed to compare the effects of oral supplementation with a fixed Polypodium leucotomos/pomegranate combination (PPmix®) versus Polypodium leucotomos alone (Fernblock®) on skin biophysical parameters of Caucasian adults. METHODS: Forty healthy adult volunteers (20 males and 20 females; mean age: 37.2±5.5 years) were randomized in a 1:1 fashion to a fixed Polypodium leucotomos/pomegranate combination (480 mg/day; n=20) or Polypodium leucotomos alone (480 mg/day; n=20) for 3 months...
February 2017: Neuro Endocrinology Letters
Indermeet Kohli, Rubina Shafi, Prescilia Isedeh, James L Griffith, Mohammed S Al-Jamal, Narumol Silpa-Archa, Bradford Jackson, Mohammed Athar, Nikiforos Kollias, Craig A Elmets, Henry W Lim, Iltefat H Hamzavi
BACKGROUND: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. OBJECTIVE: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE). METHODS: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser)...
July 2017: Journal of the American Academy of Dermatology
Mina Saeedi, Khatereh Babaie, Elahe Karimpour-Razkenari, Mahdi Vazirian, Tahmineh Akbarzadeh, Mahnaz Khanavi, Mannan Hajimahmoodi, Mohammad Reza Shams Ardekani
In this study, in vitro evaluation of cholinesterase inhibitory (ChEI) activity of various plants including betel nuts (Areca catechu L.), clove buds (Syzygium aromaticum L.), aerial parts of dodder (Cuscuta chinensis Lam.), common polypody rhizomes (Polypodium vulgare L.) and turpeth roots (Ipomoea turpethum R. Br.) which were recommended for the treatment of AD symptoms in Iranian Traditional Medicine (ITM) is reported. Among them, aqueous extract of A. catechu L. was found as the most potent anti-AChE (IC50  = 32...
November 2017: Natural Product Research
Linghong Linda Zhou, Akerke Baibergenova
Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. We sought to evaluate the efficacy and safety/tolerability of oral medications and dietary supplements for the treatment of melasma...
September 2017: International Journal of Dermatology
Paola Torricelli, Milena Fini, Pier Alessandro Fanti, Emi Dika, Massimo Milani
BACKGROUND: Polypodium leucotomos (PL) exerts potent antioxidant, photo-protective, and immune-modulatory activities. A reconstructed human epidermis (RHE) (Episkin) is a suitable model for the evaluation of acute UV-induced cell damage. No data regarding the photo-protective action of PL in this model are available. PURPOSE: We evaluated the effects of PL on the prevention of UVB-induced cell damage assessing sunburn cells, CPD formation, p53, Ki-67, p21 expression, and epidermal growth factor (EGF) production...
May 2017: Photodermatology, Photoimmunology & Photomedicine
Henry W Lim, Maria-Ivonne Arellano-Mendoza, Fernando Stengel
Electromagnetic radiation in the ultraviolet, visible, and infrared ranges all produce biologic effects. Ultraviolet filters are the most well-studied photoprotective measure for the adverse effects of ultraviolet radiation. Because of the reported endocrinologic effects of oxybenzone in animal studies, its effects on coral reefs, and its photocontact allergy potential, its use has been minimized in many countries worldwide. New developments in topical antioxidants and oral and subcutaneous agents (eg, Polypodium leucotomos extract, afamelanotide, nicotinamide) with photoprotective and antiphotocarcinogenic properties could potentially provide addition modalities for protection against the effects of visible light and infrared radiation...
March 2017: Journal of the American Academy of Dermatology
(no author information available yet)
The above article, published online on November 6, 2015 in Wiley Online Library (, has been retracted by agreement between the authors, the journal Editor in Chief, Thomas M. Ruenger, MD PhD and John Wiley & Sons Ltd. The retraction has been agreed as the clinical trial reported in this manuscript was not approved by the local Ethics Committee. Reference Calzavara-Pinton PG, Rossi MT, Zanca A, Arisi M, Gonzalez S, Venturini M. Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study...
September 2016: Photodermatology, Photoimmunology & Photomedicine
Jessica Mounessa, Talayesa Buntinx-Krieg, Rosie Qin, Cory A Dunnick, Robert P Dellavalle
The incidence of malignant melanoma (MM) continues to rise in the United States. While sun protection and full body skin examinations remain the mainstay of preventative care, chemoprevention of the deadly disease has become an increasingly popular field of study. In this focused review, we discuss current findings and analyze the risks and benefits of various agents investigated for the primary and secondary chemoprevention of MM. Such agents include topical retinoids, vitamins, and supplements, Polypodium leucotomas extracts, non-steroidal anti-inflammatory agents (NSAIDs), statins, sunscreens, and field therapy with topical imiquimod for primary and secondary chemoprevention...
December 2016: American Journal of Clinical Dermatology
Rita E Morero, David S Barrington, Monique A McHenry, João P S Condack, Gloria E Barboza
Polystichum Roth is one of the largest and most taxonomically challenging fern genera. South American species have a rich and complex nomenclatural history; many of the early names are inadequately typified. Based on extensive examination of original type material, we designate eleven lectotypes (including Aspidium mohrioides, Aspidium montevidense f. imbricata, Aspidium montevidense f. squamulosa, Aspidium plicatum, Aspidium pycnolepis, Dicksonia andina, Polystichum elegans, Polystichum mohrioides f. latifolia, Polystichum multifidum var...
2016: PhytoKeys
James Q Del Rosso
Polypodium leucotomas extract is a natural product derived from a tropical fern that is available as an over-the-counter product in the United States and several other countries. A designated brand of oral Polypodium leucotomas extract has been shown in several research studies to exhibit a variety of antioxidant and photoprotective properties. Clinical research with this same formulation of Polypodium leucotomas extract has demonstrated multiple potential therapeutic applications. This article provides a thorough overview of research completed with Polypodium leucotomas extract and outlines suggested approaches for clinical use...
May 2016: Journal of Clinical and Aesthetic Dermatology
Concepcion Parrado, Marta Mascaraque, Yolanda Gilaberte, Angeles Juarranz, Salvador Gonzalez
Healthier life styles include increased outdoors time practicing sports and walking. This means increased exposure to the sun, leading to higher risk of sunburn, photoaging and skin cancer. In addition to topical barrier products, oral supplementations of various botanicals endowed with antioxidant activity are emerging as novel method of photoprotection. Polypodium leucotomos extract (PL, commercial name Fernblock(®), IFC Group, Spain) is a powerful antioxidant due to its high content of phenolic compounds...
June 29, 2016: International Journal of Molecular Sciences
Adam J Luber, Antoanella Calame, Sharon E Jacob
A 52-year-old man with Fitzpatrick type V skin presented for evaluation of a photodistributed eruption of unknown origin. The patient reported a 20-year history of the dermatitis, with worsening severity during the past 6 years. He had required one hospital admission with intravenous methylprednisolone and two extended courses of oral prednisone (starting dose of 60 mg/d). He complained of pruritus and swelling localized to the sun-exposed areas of the forearms, face, and neck, with notable sparing of photoprotected areas of his skin...
2016: Skinmed
Ekaterina V Raikova, Olga I Raikova
Polypodium hydriforme, the only species in Polypodiozoa, which is currently considered a class of Cnidaria, and likely a sister group to Medusozoa (together with Myxozoa), is a cnidarian adapted to intracellular parasitism inside sturgeon oocytes. Free-living P. hydriforme lives on river bottoms; it walks on supporting tentacles and uses sensory tentacles to capture food and bring it to the mouth. The nervous system of free-living P. hydriforme was studied by confocal microscopy and immunohistochemistry using antibodies to FMRF-amide and α-tubulin combined with phalloidin-staining of F-actin fibres...
April 2016: Zoology: Analysis of Complex Systems, ZACS
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