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https://www.readbyqxmd.com/read/28726212/melasma-an-up-to-date-comprehensive-review
#1
REVIEW
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
July 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28456146/comparative-effects-of-a-fixed-polypodium-leucotomos-pomegranate-combination-versus-polypodium-leucotomos-alone-on-skin-biophysical-parameters
#2
RANDOMIZED CONTROLLED TRIAL
Enzo Emanuele, Marco Bertona, Marco Biagi
OBJECTIVES: Polypodium leucotomos extract is a commonly used systemic photoprotective agent. In an exploratory fashion, the current study aimed to compare the effects of oral supplementation with a fixed Polypodium leucotomos/pomegranate combination (PPmix®) versus Polypodium leucotomos alone (Fernblock®) on skin biophysical parameters of Caucasian adults. METHODS: Forty healthy adult volunteers (20 males and 20 females; mean age: 37.2±5.5 years) were randomized in a 1:1 fashion to a fixed Polypodium leucotomos/pomegranate combination (480 mg/day; n=20) or Polypodium leucotomos alone (480 mg/day; n=20) for 3 months...
February 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28341348/the-impact-of-oral-polypodium-leucotomos-extract-on-ultraviolet-b-response-a-human-clinical-study
#3
Indermeet Kohli, Rubina Shafi, Prescilia Isedeh, James L Griffith, Mohammed S Al-Jamal, Narumol Silpa-Archa, Bradford Jackson, Mohammed Athar, Nikiforos Kollias, Craig A Elmets, Henry W Lim, Iltefat H Hamzavi
BACKGROUND: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. OBJECTIVE: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE). METHODS: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser)...
July 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28278615/in-vitro-cholinesterase-inhibitory-activity-of-some-plants-used-in-iranian-traditional-medicine
#4
Mina Saeedi, Khatereh Babaie, Elahe Karimpour-Razkenari, Mahdi Vazirian, Tahmineh Akbarzadeh, Mahnaz Khanavi, Mannan Hajimahmoodi, Mohammad Reza Shams Ardekani
In this study, in vitro evaluation of cholinesterase inhibitory (ChEI) activity of various plants including betel nuts (Areca catechu L.), clove buds (Syzygium aromaticum L.), aerial parts of dodder (Cuscuta chinensis Lam.), common polypody rhizomes (Polypodium vulgare L.) and turpeth roots (Ipomoea turpethum R. Br.) which were recommended for the treatment of AD symptoms in Iranian Traditional Medicine (ITM) is reported. Among them, aqueous extract of A. catechu L. was found as the most potent anti-AChE (IC50 = 32...
March 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28239840/melasma-systematic-review-of-the-systemic-treatments
#5
REVIEW
Linghong Linda Zhou, Akerke Baibergenova
Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. We sought to evaluate the efficacy and safety/tolerability of oral medications and dietary supplements for the treatment of melasma...
September 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28140474/protective-effects-of-polypodium-leucotomos-extract-against-uvb-induced-damage-in-a-model-of-reconstructed-human-epidermis
#6
Paola Torricelli, Milena Fini, Pier Alessandro Fanti, Emi Dika, Massimo Milani
BACKGROUND: Polypodium leucotomos (PL) exerts potent antioxidant, photo-protective, and immune-modulatory activities. A reconstructed human epidermis (RHE) (Episkin) is a suitable model for the evaluation of acute UV-induced cell damage. No data regarding the photo-protective action of PL in this model are available. PURPOSE: We evaluated the effects of PL on the prevention of UVB-induced cell damage assessing sunburn cells, CPD formation, p53, Ki-67, p21 expression, and epidermal growth factor (EGF) production...
May 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28038886/current-challenges-in-photoprotection
#7
Henry W Lim, Maria-Ivonne Arellano-Mendoza, Fernando Stengel
Electromagnetic radiation in the ultraviolet, visible, and infrared ranges all produce biologic effects. Ultraviolet filters are the most well-studied photoprotective measure for the adverse effects of ultraviolet radiation. Because of the reported endocrinologic effects of oxybenzone in animal studies, its effects on coral reefs, and its photocontact allergy potential, its use has been minimized in many countries worldwide. New developments in topical antioxidants and oral and subcutaneous agents (eg, Polypodium leucotomos extract, afamelanotide, nicotinamide) with photoprotective and antiphotocarcinogenic properties could potentially provide addition modalities for protection against the effects of visible light and infrared radiation...
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27870132/retraction-oral-polypodium-leucomotos-increases-the-anti-inflammatory-and-melanogenic-responses-of-the-skin-to-different-modalities-of-sun-exposures-a-pilot-study-by-calzavara-pinton-pg-rossi-mt-zanca-a-arisi-m-gonzalez-s-and-venturini-m
#8
(no author information available yet)
The above article, published online on November 6, 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Thomas M. Ruenger, MD PhD and John Wiley & Sons Ltd. The retraction has been agreed as the clinical trial reported in this manuscript was not approved by the local Ethics Committee. Reference Calzavara-Pinton PG, Rossi MT, Zanca A, Arisi M, Gonzalez S, Venturini M. Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study...
2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27665299/primary-and-secondary-chemoprevention-of-malignant-melanoma
#9
REVIEW
Jessica Mounessa, Talayesa Buntinx-Krieg, Rosie Qin, Cory A Dunnick, Robert P Dellavalle
The incidence of malignant melanoma (MM) continues to rise in the United States. While sun protection and full body skin examinations remain the mainstay of preventative care, chemoprevention of the deadly disease has become an increasingly popular field of study. In this focused review, we discuss current findings and analyze the risks and benefits of various agents investigated for the primary and secondary chemoprevention of MM. Such agents include topical retinoids, vitamins, and supplements, Polypodium leucotomas extracts, non-steroidal anti-inflammatory agents (NSAIDs), statins, sunscreens, and field therapy with topical imiquimod for primary and secondary chemoprevention...
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27489490/typifications-and-synonymy-in-polystichum-dryopteridaceae-from-chile-and-argentina
#10
Rita E Morero, David S Barrington, Monique A McHenry, João P S Condack, Gloria E Barboza
Polystichum Roth is one of the largest and most taxonomically challenging fern genera. South American species have a rich and complex nomenclatural history; many of the early names are inadequately typified. Based on extensive examination of original type material, we designate eleven lectotypes (including Aspidium mohrioides, Aspidium montevidense f. imbricata, Aspidium montevidense f. squamulosa, Aspidium plicatum, Aspidium pycnolepis, Dicksonia andina, Polystichum elegans, Polystichum mohrioides f. latifolia, Polystichum multifidum var...
2016: PhytoKeys
https://www.readbyqxmd.com/read/27386044/use-of-polypodium-leucotomas-extract-in-clinical-practice-a-primer-for-the-clinician
#11
REVIEW
James Q Del Rosso
Polypodium leucotomas extract is a natural product derived from a tropical fern that is available as an over-the-counter product in the United States and several other countries. A designated brand of oral Polypodium leucotomas extract has been shown in several research studies to exhibit a variety of antioxidant and photoprotective properties. Clinical research with this same formulation of Polypodium leucotomas extract has demonstrated multiple potential therapeutic applications. This article provides a thorough overview of research completed with Polypodium leucotomas extract and outlines suggested approaches for clinical use...
May 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27367679/fernblock-polypodium-leucotomos-extract-molecular-mechanisms-and-pleiotropic-effects-in-light-related-skin-conditions-photoaging-and-skin-cancers-a-review
#12
REVIEW
Concepcion Parrado, Marta Mascaraque, Yolanda Gilaberte, Angeles Juarranz, Salvador Gonzalez
Healthier life styles include increased outdoors time practicing sports and walking. This means increased exposure to the sun, leading to higher risk of sunburn, photoaging and skin cancer. In addition to topical barrier products, oral supplementations of various botanicals endowed with antioxidant activity are emerging as novel method of photoprotection. Polypodium leucotomos extract (PL, commercial name Fernblock(®), IFC Group, Spain) is a powerful antioxidant due to its high content of phenolic compounds...
June 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27072735/use-of-oral-polypodium-leucotomos-extract-in-chronic-photoinduced-hypersensitivity-dermatitis
#13
Adam J Luber, Antoanella Calame, Sharon E Jacob
A 52-year-old man with Fitzpatrick type V skin presented for evaluation of a photodistributed eruption of unknown origin. The patient reported a 20-year history of the dermatitis, with worsening severity during the past 6 years. He had required one hospital admission with intravenous methylprednisolone and two extended courses of oral prednisone (starting dose of 60 mg/d). He complained of pruritus and swelling localized to the sun-exposed areas of the forearms, face, and neck, with notable sparing of photoprotected areas of his skin...
2016: Skinmed
https://www.readbyqxmd.com/read/26897553/nervous-system-immunohistochemistry-of-the-parasitic-cnidarian-polypodium-hydriforme-at-its-free-living-stage
#14
Ekaterina V Raikova, Olga I Raikova
Polypodium hydriforme, the only species in Polypodiozoa, which is currently considered a class of Cnidaria, and likely a sister group to Medusozoa (together with Myxozoa), is a cnidarian adapted to intracellular parasitism inside sturgeon oocytes. Free-living P. hydriforme lives on river bottoms; it walks on supporting tentacles and uses sensory tentacles to capture food and bring it to the mouth. The nervous system of free-living P. hydriforme was studied by confocal microscopy and immunohistochemistry using antibodies to FMRF-amide and α-tubulin combined with phalloidin-staining of F-actin fibres...
April 2016: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/26885792/polypodium-leucotomos-an-overview-of-basic-investigative-findings
#15
REVIEW
Brian Berman, Charles Ellis, Craig Elmets
The use of Polypodium leucotomos, a species of fern, has been reported to be beneficial in the treatment of atopic dermatitis, vitiligo, and psoriasis, and for prevention of polymorphic light eruption, sunburn, and squamous cell carcinoma. We review the in vivo animal, in vitro human, and human clinical studies performed to help elucidate the actions of and biologic pathways affected by P. leucotomos. These results serve as the scientific rationale and basis for the protection and effectiveness afforded by P...
February 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/26830727/myxozoa-polypodium-a-common-route-to-endoparasitism
#16
COMMENT
Beth Okamura, Alexander Gruhl
Recent evidence places the problematic Polypodium, a parasite of fish eggs, firmly as sister taxon to Myxozoa within the Cnidaria. This resolution suggests a single route to endoparasitism in Cnidaria, with larval stages of a common ancestor exploiting fish as first hosts. It also enables new interpretations and insights regarding evolutionary transitions associated with endoparasitism.
April 2016: Trends in Parasitology
https://www.readbyqxmd.com/read/26783703/mechanisms-of-photoaging-and-cutaneous-photocarcinogenesis-and-photoprotective-strategies-with-phytochemicals
#17
REVIEW
Ricardo Bosch, Neena Philips, Jorge A Suárez-Pérez, Angeles Juarranz, Avani Devmurari, Jovinna Chalensouk-Khaosaat, Salvador González
Photoaging and photocarcinogenesis are primarily due to solar ultraviolet (UV) radiation, which alters DNA, cellular antioxidant balance, signal transduction pathways, immunology, and the extracellular matrix (ECM). The DNA alterations include UV radiation induced thymine-thymine dimers and loss of tumor suppressor gene p53. UV radiation reduces cellular antioxidant status by generating reactive oxygen species (ROS), and the resultant oxidative stress alters signal transduction pathways such as the mitogen-activated protein kinase (MAPK), the nuclear factor-kappa beta (NF-κB)/p65, the janus kinase (JAK), signal transduction and activation of transcription (STAT) and the nuclear factor erythroid 2-related factor 2 (Nrf2)...
March 26, 2015: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/26767294/-analysis-of-volatile-components-of-polypodium-hastatum-by-gc-ms
#18
Wen-ting Zhang, Yin-xia Zhao, Ai-guo Meng, Chun-yan Liu, Jing-yu Duan, Huan-kai Yao, Yan Li
OBJECTIVE: To further reveal the chemical constituents of Polypodium hastatum, volatile components from this plant were investigated. METHODS: The volatile components were extracted under reflux from the whole plant of Polypodium hastatum, and then analyzed qualitatively and quantitatively by GC-MS. RESULTS: 60 volatile components were detected and of all components detected, the structures and relative contents of 34 volatile compounds were elucidated...
May 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/26763327/the-fern-cavitation-catapult-mechanism-and-design-principles
#19
C Llorens, M Argentina, N Rojas, J Westbrook, J Dumais, X Noblin
Leptosporangiate ferns have evolved an ingenious cavitation catapult to disperse their spores. The mechanism relies almost entirely on the annulus, a row of 12-25 cells, which successively: (i) stores energy by evaporation of the cells' content, (ii) triggers the catapult by internal cavitation, and (iii) controls the time scales of energy release to ensure efficient spore ejection. The confluence of these three biomechanical functions within the confines of a single structure suggests a level of sophistication that goes beyond most man-made devices where specific structures or parts rarely serve more than one function...
January 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/26627241/genomic-insights-into-the-evolutionary-origin-of-myxozoa-within-cnidaria
#20
E Sally Chang, Moran Neuhof, Nimrod D Rubinstein, Arik Diamant, Hervé Philippe, Dorothée Huchon, Paulyn Cartwright
The Myxozoa comprise over 2,000 species of microscopic obligate parasites that use both invertebrate and vertebrate hosts as part of their life cycle. Although the evolutionary origin of myxozoans has been elusive, a close relationship with cnidarians, a group that includes corals, sea anemones, jellyfish, and hydroids, is supported by some phylogenetic studies and the observation that the distinctive myxozoan structure, the polar capsule, is remarkably similar to the stinging structures (nematocysts) in cnidarians...
December 1, 2015: Proceedings of the National Academy of Sciences of the United States of America
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