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generics AND quality

Yousef Jaradat, Morten Birkeland Nielsen, Petter Kristensen, Rita Bast-Pettersen
BACKGROUND: Shift work is associated with sleep disturbances, mental health problems, and job dissatisfaction. Disparities between male and female nurses in the effect of shift work on mental distress and job satisfaction have been scarcely studied. We aimed to examine differences between female and male nurses in the associations between shift work and job satisfaction and mental health. METHODS: In this cross-sectional study, male and female nurses were recruited to rate their job satisfaction on the Generic Job Satisfaction Scale and to complete the General Health Questionnaire (GHQ-30)...
February 21, 2018: Lancet
Lisa G Sorensen, Katie Neighbors, Regina M Hardison, Kathleen M Loomes, James W Varni, Vicky L Ng, Robert H Squires, Estella M Alonso
OBJECTIVE: To determine health-related quality of life (HRQoL) and neurocognitive impairment in survivors of pediatric acute liver failure (PALF). STUDY DESIGN: A longitudinal prospective study was conducted. At 6 and 12 months after PALF presentation, surveys of HRQoL were completed for 2- to 19-year-olds and executive functioning for ages 2-16 years. At 12 months, patients 3-16 years of age completed neurocognitive testing. HRQoL scores were compared with a healthy, matched sample...
March 16, 2018: Journal of Pediatrics
Muhammad Atif, Muhammad Azeem, Muhammad Rehan Sarwar, Iram Malik, Wajiha Ahmad, Fariha Hassan, Ayesha Rehman, Mahjabeen Rana
BACKGROUND: Appropriate use of medicines is important to provide quality health. The aim of this study was to assess the prescribing practices and prescription errors in the private clinic practices of Bahawalpur, Pakistan. METHODS: A cross-sectional observational study was performed in March 2015 to assess the prescribing practices and prescription errors in the private clinical practices of Bahawalpur, Pakistan. We used the standard World Health Organization (WHO) methodology to achieve the study objectives...
March 13, 2018: Journal of the Chinese Medical Association: JCMA
Fauzia A Khan, Alan F Merry
The safety of anesthesia characteristic of high-income countries today is not matched in low-resource settings with poor infrastructure, shortages of anesthesia providers, essential drugs, equipment, and supplies. Health care is delivered through complex systems. Achieving sustainable widespread improvement globally will require an understanding of how to influence such systems. Health outcomes depend not only on a country's income, but also on how resources are allocated, and both vary substantially, between and within countries...
April 2018: Anesthesia and Analgesia
Romina Torres, Claudia Zajer, Marcela Menéndez, María José Canessa, Jaime Cerda, María Angélica Wietstruck, Pamela Zúñiga
INTRODUCTION: Heavy menstrual bleeding (HMB) occurs in 37% of adolescents and compromise their quality of life. OBJECTIVE: To measure the magnitude of the impact of the SME on the quality of life in adolescents. PATIENTS AND METHOD: We interviewed adolescents diagnosed with HMB between 10 and 18 years old and one of their guardians. PedsQL 4.0 generic core scale was applied to measure quality of life, its Proxy PedsQL 4.0 version was applied to the guardian and 3 more questions to adolescents about limitation of daily activities...
December 2017: Revista Chilena de Pediatría
D Roorda, M J Witvliet, L M Wellens, D V Schulten, C E J Sloots, I de Blaauw, P M A Broens, J Oosterlaan, L W E van Heurn, A F W van der Steeg
AIM: Total colonic aganglionosis (TCA) is a severe form of Hirschsprung's Disease (HD) associated with a high morbidity. This study assesses long-term functional outcome and Quality of Life (QoL) of TCA patients in a national consecutive cohort. METHODS: Medical records of all patients (n=53) diagnosed between 1995 and 2015 were reviewed on surgical and demographic characteristics. Functional outcome of all non-syndromal patients, aged ≥ four years (n=35) was assessed in medical records and with a questionnaire...
March 15, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Thomas Waltemate, Dominik Gall, Daniel Roth, Mario Botsch, Marc Erich Latoschik
This article reports the impact of the degree of personalization and individualization of users' avatars as well as the impact of the degree of immersion on typical psychophysical factors in embodied Virtual Environments. We investigated if and how virtual body ownership (including agency), presence, and emotional response are influenced depending on the specific look of users' avatars, which varied between (1) a generic hand-modeled version, (2) a generic scanned version, and (3) an individualized scanned version...
April 2018: IEEE Transactions on Visualization and Computer Graphics
C Gassner, R Karlsson, F Lipsmeier, J Moelleken
Previously we have introduced two SPR-based assay principles (dual-binding assay and bridging assay), which allow the determination of two out of three possible interaction parameters for bispecific molecules within one assay setup: two individual interactions to both targets, and/or one simultaneous/overall interaction, which potentially reflects the inter-dependency of both individual binding events. However, activity and similarity are determined by comparing report points over a concentration range, which also mirrors the way data is generated by conventional ELISA-based methods So far, binding kinetics have not been specifically considered in generic approaches for activity assessment...
March 6, 2018: Journal of Pharmaceutical and Biomedical Analysis
Federica Pederiva, Basem Khalil, Antonino Morabito, Sarah J Wood
BACKGROUND:  Short bowel syndrome (SBS) has an impact on children and their families not only physically, but also emotionally, mentally, and socially. This study aimed to evaluate quality of life and family impact in patients with SBS, using the Pediatric Quality of Life Inventory (PedsQL) measurement model. MATERIALS AND METHODS:  PedsQL questionnaires were administered to patients with SBS followed at the Pediatric Surgery of Royal Manchester Children's Hospital...
January 30, 2018: European Journal of Pediatric Surgery
Gergely Horváth, Teodóra Keleti, Mihály Makara, Gabor S Ungvari, Gábor Gazdag
PURPOSE: To assess the quality of life (QoL) of patients with hepatitis C infection (HCI) and its correlations with demographic and clinical variables. DESIGN AND METHODS: QoL and depressive symptoms were evaluated with the validated rating instruments of the 36-item short form (SF-36) generic health survey and the second version of the self-rated Beck depression inventory (BDI-II) in a cross-sectional design and correlated with basic demographic and clinical variables, including the Fibroscan score, which indicates the severity of liver impairment...
March 12, 2018: Perspectives in Psychiatric Care
Lili Zhang, Tao Gao, Yi Shen
OBJECTIVE: To study the quality of life of Chinese pediatric patients with retinoblastoma (RB) after enucleation and the influencing factors. METHODS: A questionnaire survey was performed on 71 cases of pediatric patients with RB after enucleation and 80 cases of healthy children, using the Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQL™ 4.0). RESULTS: The social dimension scores, school dimension scores, and total scores for the PedsQL™ 4...
March 12, 2018: Pediatric Blood & Cancer
Andreas Liefeith, John Kiely, Dave Collins, Jim Richards
Perhaps as a consequence of increased specialism in training and support, the focus on engendering and maintaining agility as a generic quality has diminished within many contemporary sports performance programmes. Reflecting this, we outline a rationale suggesting that such a decreased focus represents an oversight which may be detrimental to maximising the potential of performers. We present an evidence-based argument that both generic and specific elements of agility performance should be consistently emphasised within long-term performance-training programmes...
March 9, 2018: Journal of Sports Sciences
Matthew C Bunte, David J Cohen, Michael R Jaff, William A Gray, Elizabeth A Magnuson, Haiyan Li, Andrew Feiring, Marco Cioppi, Robert Hibbard, Bruce Gray, Yazan Khatib, David Jessup, Roberto Patarca, Jing Du, Hans-Peter Stoll, Joe Massaro, David M Safley
OBJECTIVES: To evaluate the clinical and health status outcomes of patients undergoing superficial femoral artery (SFA) revascularization using the Shape Memory Alloy Recoverable Technology (S.M.A.R.T.®) nitinol self-expanding stent through 3 years of follow-up. BACKGROUND: Limited long-term data are available describing the durability of benefits after femoropopliteal revascularization. METHODS: In a multicenter, prospective, core-lab adjudicated study, 250 subjects with de novo or restenotic femoropopliteal arterial lesions were treated with the S...
March 9, 2018: Catheterization and Cardiovascular Interventions
Katelynn Crick, Fatima Al Sayah, Arto Ohinmaa, Jeffrey A Johnson
BACKGROUND: Anxiety and depression disorders are associated with significantly lower health-related quality of life (HRQL). The EQ-5D is a commonly used generic measure of HRQL; it captures mental health through a single domain-the anxiety/depression dimension. Evidence on the responsiveness of this measure in assessing changes in mental health changes is limited. OBJECTIVE: To examine the performance of the anxiety/depression dimension (A/D) of the 3- and 5-level (3L and 5L) versions of the EQ-5D in assessing changes in mental health...
March 7, 2018: Quality of Life Research
Isaac Bos, Klaske Wynia, Josué Almansa, Gea Drost, Berry Kremer, Jan Kuks
PURPOSE: People with neuromuscular disease experience lower quality of life levels than people from the general population. We examined the prevalence and severity of a broad range of neuromuscular disease-related disabilities and their impact on health-related quality of life. MATERIALS AND METHODS: A cross-sectional postal survey study was conducted among patients diagnosed with neuromuscular disease. Patients completed the Neuromuscular Disease Impact Profile, a disease-related disability impact questionnaire, and two generic health-related quality of life questionnaires: the medical outcome study Short Form Questionnaire and the World Health Organization Quality of Life-bref...
March 8, 2018: Disability and Rehabilitation
Donhyun Shin, Jae-Don Oh, Kyung-Hye Won, Ki-Duk Song
Objective: Non-synonymous single nucleotide polymorphisms (nsSNPs) were identified nsSNPs in Berkshire selective sweep regions and investigated Berkshire-specific nsSNPs to discover genetic nsSNP mechanisms that were potentially associated with Berkshire domestication and meat quality. We further used bioinformatics tools to predict damaging amino-acid substitutions in Berkshire-related nsSNPs. Methods: NsSNPs were examined in whole genome resequencing data of 110 pigs, including 14 Berkshire pigs, generated using the Illumina Hiseq2000 platform to identify variations that might affect meat quality in Berkshire pigs...
March 2, 2018: Asian-Australasian Journal of Animal Sciences
Stephen P Adams, Sarpreet S Sekhon, Michael Tsang, James M Wright
BACKGROUND: Fluvastatin is thought to be the least potent statin on the market, however, the dose-related magnitude of effect of fluvastatin on blood lipids is not known. OBJECTIVES: Primary objectiveTo quantify the effects of various doses of fluvastatin on blood total cholesterol, low-density lipoprotein (LDL cholesterol), high-density lipoprotein (HDL cholesterol), and triglycerides in participants with and without evidence of cardiovascular disease.Secondary objectivesTo quantify the variability of the effect of various doses of fluvastatin...
March 6, 2018: Cochrane Database of Systematic Reviews
Ruchika Talwar, Justin Ziemba
PURPOSE OF REVIEW: With the emphasis on quality standards when determining reimbursements rates, patient reported outcomes are now of particular interest to clinicians. This review addresses health-related quality of life (HRQOL) detriments that have been studied in patients with stone disease. RECENT FINDINGS: Several instruments been validated for use in stone formers. Previously, generic instruments revealed decreased HRQOL in urolithiasis patients. Recently, a disease-specific tool has been developed and has provided more insight into the specific symptoms that negatively affect the patient experience...
March 5, 2018: Current Urology Reports
Daniel Altman, Kirk Geale, Christian Falconer, Edward Morcos
INTRODUCTION AND HYPOTHESIS: The aim of this study was to investigate the use of a generic and globally accessible instrument for assessing health-related quality of life (HR-QoL) in pelvic organ prolapse (POP) surgery. METHODS: In a prospective multicenter setting, 207 women underwent surgery for apical prolapse [stage ≥2, Pelvic Organ Prolapse Quantificcation (POP-Q) system] with or without anterior wall defect. Demographic and surgical characteristics were collected before surgery...
March 6, 2018: International Urogynecology Journal
Jigyasa Sharma, Meaghan O'Connor, R Rima Jolivet
In high-income countries, group antenatal care (ANC) offers an alternative to individual care and is associated with improved attendance, client satisfaction, and health outcomes for pregnant women and newborns. In low- and middle-income country (LMIC) settings, this model could be adapted to address low antenatal care uptake and improve quality. However, evidence on key attributes of a group care model for low-resource settings remains scant. We conducted a systematic review of the published literature on models of group antenatal care in LMICs to identify attributes that may increase the relevance, acceptability and effectiveness of group ANC in such settings...
March 5, 2018: Reproductive Health
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