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https://www.readbyqxmd.com/read/29149549/workflow-for-target-oriented-parametrization-of-an-enhanced-mechanistic-cell-culture-model
#1
Sophia Ulonska, Paul Kroll, Jens Fricke, Christoph Clemens, Raphael Voges, Markus Michael Müller, Christoph Herwig
The goal of this study was to develop a macroscopic mechanistic model describing growth and production within fed-batch cultivations of CHO cells. The model should be used for process characterization as well as for process monitoring including real-time parameter adaptations. The model proved to be able to describe a data-set of 40 processes differing in clones, scales and process conditions with a normalized root mean square error of approximately 10%. However, due to limited parameter identifiability and limited knowledge about physiologically meaningful parameter values, a broad range of parameters could describe the data with similar quality...
November 17, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29149441/evidence-on-the-longitudinal-construct-validity-of-major-generic-and-utility-measures-of-health-related-quality-of-life-in-teens-with-depression
#2
John F Dickerson, David H Feeny, Gregory N Clarke, Alex L MacMillan, Frances L Lynch
PURPOSE: To examine the longitudinal construct validity in the assessment of changes in depressive symptoms of widely used utility and generic HRQL instruments in teens. METHODS: 392 teens enrolled in the study and completed HRQL and diagnostic measures as part of the baseline interview. HRQL measures included EuroQol (EQ-5D-3L), Health Utilities Index Mark 2 (HUI2) and Mark 3 (HUI3), Quality of Well-Being Scale (QWB), Pediatric Quality of Life Inventory (PEDS-QL), RAND-36 (SF-6D), and Quality of Life in Depression Scale (QLDS)...
November 17, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29148810/enhancement-of-light-absorption-in-silicon-nanowire-photovoltaic-devices-with-dielectric-and-metallic-grating-structures
#3
Jin-Sung Park, Kyoung-Ho Kim, Min-Soo Hwang, Xing Zhang, Jung Min Lee, Jungkil Kim, Kyung-Deok Song, You-Shin No, Kwang-Yong Jeong, James F Cahoon, Sun-Kyung Kim, Hong-Gyu Park
We report the enhancement of light absorption in Si nanowire photovoltaic devices with one-dimensional dielectric or metallic gratings that are fabricated by a damage-free, precisely aligning, polymer-assisted transfer method. Incorporation of a Si3N4 grating with a Si nanowire effectively enhances the photocurrents for transverse-electric polarized light. The wavelength at which a maximum photocurrent is generated is readily tuned by adjusting the grating pitch. Moreover, the electrical properties of the nanowire devices are preserved before and after transferring the Si3N4 gratings onto Si nanowires, ensuring that the quality of pristine nanowires is not degraded during the transfer...
November 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/29145831/copd-online-rehabilitation-versus-conventional-copd-rehabilitation-rationale-and-design-for-a-multicenter-randomized-controlled-trial-study-protocol-core-trial
#4
Henrik Hansen, Theresa Bieler, Nina Beyer, Nina Godtfredsen, Thomas Kallemose, Anne Frølich
BACKGROUND: Rehabilitation of patients with chronic obstructive pulmonary disease (COPD) is a key treatment in COPD. However, despite the existing evidence and a strong recommendation from lung associations worldwide, 50% of patients with COPD decline to participate in COPD rehabilitation program and 30-50% drop-out before completion. The main reasons are severe symptoms, inflexible accessibility and necessity for transportation. Currently there are no well-established and evident rehabilitation alternatives...
November 16, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29141645/measuring-quality-of-life-among-people-living-with-hiv-a-systematic-review-of-reviews
#5
REVIEW
Vanessa Cooper, Jane Clatworthy, Richard Harding, Jennifer Whetham
AIM: A systematic review of reviews was conducted to identify and appraise brief measures of health-related quality of life (HRQoL) that have been used in peer-reviewed research with people living with HIV. METHODS: The review was conducted in two stages: 1) search of electronic databases to identify systematic reviews of tools used to measure HRQoL in adults living with HIV, published since the year 2000; 2) selection of HRQol scales from those identified in the reviews...
November 15, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29141265/-hbv-infections-in-germany-health-care-costs-in-a-real-life-setting
#6
Jona Theodor Stahmeyer, Hans Becker, Anna Lena Orlemann, Christian Krauth, Michael P Manns, Heiner Wedemeyer
Background An estimated 500 000 people are infected with hepatitis B in Germany, inducing an enormous burden on infected patients and the health care system. The aim of our study was to estimate the real-life costs of treating hepatitis B and to analyze sociodemographic factors. Methods We conducted a retrospective, non-interventional, single-center study from 07/2009 to 12/2012. Information on health care delivery was extracted from patient records. Besides that, a questionnaire survey regarding sociodemographic parameters and quality of life of HBV-infected patients was performed...
November 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29140637/hazard-identification-and-risk-assessment-for-improving-farm-safety-on-canadian-farms
#7
Hassan S Chattha, Kenneth W Corscadden, Qamar U Zaman
Agriculture is one of the most hazardous industries worldwide. The number of serious accidents on farms, despite sophisticated technology, development of effective prevention methods, and high-quality training and improved skill levels of farmers, is still very high. The purpose of this study was to develop and apply a generic farm safety protocol to hazards that have been identified in previously published literature and demonstrate the potential benefits of such a protocol with a view to raising awareness of farm safety...
July 31, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29139310/pudendal-nerve-injury-impairs-anorectal-function-and-health-related-quality-of-life-measures-%C3%A2-2-years-after-3d-conformal-radiotherapy-for-prostate-cancer
#8
Eng Eric Yeoh, Rochelle Botten, Addolorata Di Matteo, Marcus Tippett, Jonathon Hutton, Robert Fraser, Phillip G Dinning, David Wattchow
PURPOSE: To compare GI symptoms, measures of generic and disease specific health related quality of life (HRQoL), anorectal and pudendal nerve function and anal sphincter morphology between (i) patients ≥2 years after 3D conformal radiotherapy (3D-CRT)±high dose rate (HDR) brachytherapy for carcinoma of the prostate and aged matched patients before radiotherapy and (ii) symptomatic and asymptomatic patients ≥2 years after 3D-CRT ± HDR brachytherapy. MATERIAL AND METHODS: Methodology included: (i) modified LENT-SOMA scales for GI symptoms, (ii) EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires for generic and disease specific HRQoL, (iii) anorectal manometry and terminal motor latency for anorectal and pudendal nerve function and (iv) endorectal ultrasound for anal sphincter morphology...
November 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29134668/factors-affecting-patient-reported-outcomes-after-red-blood-cell-transfusion-in-medical-patients
#9
Ka Lok Luke Chan, Wai Man Vivien Mak, Yat Hung Tam, Kwok Kuen Harold Lee
BACKGROUND: Physical variables like mortality or cardiac events were used to evaluate the requirement of red blood cell (RBC) transfusion. However, patient-reported outcomes (PROs) of blood transfusion recipients were seldom assessed. The health-related quality of life (HRQoL) of patients before and after RBC transfusion was compared in this study. STUDY DESIGN AND METHODS: The study period was February to June 2016. Standardized generic and anemia symptom-specific HRQoL instruments were administered to patients receiving RBC transfusion in the medical unit of a single center...
November 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29132088/analysing-the-impacts-of-air-quality-policies-on-ecosystem-services-a-case-study-for-telemark-norway
#10
L Hein, L White, A Miles, P Roberts
There is an increasing interest in considering the effects of air pollution on ecosystem services supply in order to enhance cost-benefit analyses of air pollution policies. This paper presents a generic, conceptual approach that can be used to link atmospheric deposition of air pollutants to ecosystem services supply and societal benefits. The approach is applied in a case study in the Telemark county of Norway. First, we examine the potential effects of four European air quality policy scenarios on N deposition in the ecosystems of this county...
November 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29131111/physical-activity-and-fatigue-in-patients-with-sarcoidosis
#11
Thomas Bahmer, Henrik Watz, Maria Develaska, Benjamin Waschki, Klaus F Rabe, Helgo Magnussen, Detlef Kirsten, Anne-Marie Kirsten
BACKGROUND: Little is known about physical activity in daily life among patients with sarcoidosis. Fatigue is a frequent and disabling symptom that might negatively affect physical activity levels. METHODS: In patients with sarcoidosis, we measured physical activity (steps per day) by accelerometry (SenseWear Armband) for 1 week. We assessed lung function (DLCO, FVC), exercise capacity (6-min walking distance [6MWD]), health-related quality of life (St George's Respiratory Questionnaire [SGRQ]), generic quality of life (12-Item Short-Form Health Survey [SF-12]), and fatigue (Multidimensional Fatigue Inventory [MFI-20])...
November 9, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29129385/effect-directed-fingerprints-of-77-botanical-extracts-via-a-generic-high-performance-thin-layer-chromatography-method-combined-with-assays-and-mass-spectrometry
#12
S Krüger, L Hüsken, R Fornasari, I Scainelli, G E Morlock
Quantitative effect-directed profiles of 77 industrially and freshly extracted botanicals like herbs, spices, vegetables and fruits, widely used as food ingredients, dietary supplements or traditional medicine, gave relevant information on their quality. It allows the assessment of food, dietary supplements and phytomedicines with regard to potential health-promoting activities. In contrary to sum parameter assays and targeted analysis, chromatography combined with effect-directed analysis allows fast assignment of single active compounds and evaluation of their contribution to the overall activity, originating from a food or botanical sample...
October 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29129379/children-with-epilepsy-against-their-healthy-peers-and-those-with-headaches-differences-similarities
#13
Dorota Talarska, Michał Michalak, Patrycja Talarska, Barbara Steinborn
INTRODUCTION: Epilepsy, like most chronic diseases, affects bio-psycho-social functioning of children and adolescents. The aim of this work was to assess functioning of children with epilepsy compared with the group of healthy children and those with headaches carried out by children themselves and their mothers. MATERIAL AND METHODS: The study included 209 children with epilepsy and 173 children with headaches and 182 healthy students and their mothers. The research tool was Pediatric Quality of Life Inventory 4...
October 27, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29128726/joint-release-rate-estimation-and-measurement-by-measurement-model-correction-for-atmospheric-radionuclide-emission-in-nuclear-accidents-an-application-to-wind-tunnel-experiments
#14
Xinpeng Li, Hong Li, Yun Liu, Wei Xiong, Sheng Fang
The release rate of atmospheric radionuclide emissions is a critical factor in the emergency response to nuclear accidents. However, there are unavoidable biases in radionuclide transport models, leading to inaccurate estimates. In this study, a method that simultaneously corrects these biases and estimates the release rate is developed. Our approach provides a more complete measurement-by-measurement correction of the biases with a coefficient matrix that considers both deterministic and stochastic deviations...
October 29, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29128411/psychometric-properties-of-the-kidney-disease-quality-of%C3%A2-life-36-item-short-form-survey-kdqol-36-in-the%C3%A2-united%C3%A2-states
#15
John D Peipert, Peter M Bentler, Kristi Klicko, Ron D Hays
BACKGROUND: The Centers for Medicare & Medicaid Services require that dialysis patients' health-related quality of life be assessed annually. The primary instrument used for this purpose is the Kidney Disease Quality of Life 36-Item Short-Form Survey (KDQOL-36), which includes the SF-12 as its generic core and 3 kidney disease-targeted scales: Burden of Kidney Disease, Symptoms and Problems of Kidney Disease, and Effects of Kidney Disease. Despite its broad use, there has been limited evaluation of KDQOL-36's psychometric properties...
November 8, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29121918/-no-generics-doctor-the-perspective-of-general-practitioners-in-two-french-regions
#16
Béatrice Riner, Adèle Bussy, Jeannie Hélène-Pelage, Nycrees Moueza, Sébastien Lamy, Philippe Carrère
BACKGROUND: Generic medicines are essential to controlling health expenditures. Their market share is still small in France. The discourse and practices of prescribers may play a major role in their use. The purpose of this study was to explore the knowledge, attitudes and practices of general practitioners (GPs) toward generic medicines in two French regions with the lowest penetration rate of these products. METHODS: An observational study was carried out from October 2015 to February 2016 in Guadeloupe and Martinique...
November 9, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29114914/a-bayesian-scoring-rule-on-clustered-event-data-for-familial-risk-assessment-an-example-from-colorectal-cancer-screening
#17
Anna K Rieger, Ulrich R Mansmann
Colorectal cancer screening is well established. The identification of high risk populations is the key to implement effective risk-adjusted screening. Good statistical approaches for risk prediction do not exist. The family's colorectal cancer history is used for identification of high risk families and usually assessed by a questionnaire. This paper introduces a prediction algorithm to designate a family for colorectal cancer risk and discusses its statistical properties. The new algorithm uses Bayesian reasoning and a detailed family history illustrated by a pedigree and a Lexis diagram...
November 8, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29114239/botulinumtoxin-improves-both-generic-and-disease-specific-quality-of-life-in-cervical-dystonia
#18
Daniel Weiss, Leonhard Hieber, Justine Sturm, Axel Börtlein, Ingo Mayr, Matthias Appy, Benedicta Kühnler, Joachim Buchthal, Christian Dippon, Guy Arnold, Tobias Wächter
Botulinumtoxin injection (BoNT) into affected muscles is effective to improve motor symptoms of cervical dystonia (CD) by reducing muscle contraction and involuntary dystonic movement and posturing. However, the understanding of the effect on health-related quality of life (HR-QoL) and patient referral under HR-QoL aspects is incomplete. In this open-label clinical prospective observational study, we characterized the outcomes in CD (n = 159) from botulinumtoxin on both generic HR-QoL (EuroQol; EQ-5D-5L) and disease-specific HR-QoL [craniocervical dystonia questionnaire (CDQ-24)]...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29112230/longitudinal-analysis-of-quality-of-life-outcomes-in-children-during-treatment-for-acute-lymphoblastic-leukemia-a-report-from-the-children-s-oncology-group-aall0932-trial
#19
Daniel J Zheng, Xiaomin Lu, Reuven J Schore, Lyn Balsamo, Meenakshi Devidas, Naomi J Winick, Elizabeth A Raetz, Mignon L Loh, William L Carroll, Lillian Sung, Stephen P Hunger, Anne L Angiolillo, Nina S Kadan-Lottick
BACKGROUND: Children with average-risk acute lymphoblastic leukemia (AR-ALL) face many challenges that can adversely affect their quality of life (QOL). However, to the authors' knowledge, patterns and predictors of QOL impairment during therapy have not been well characterized to date. METHODS: Patients with AR-ALL who were enrolled on the Children's Oncology Group AALL0932 trial were offered participation in this prospective cohort study if they were aged ≥4 years at the time of diagnosis and had an English-speaking parent...
November 7, 2017: Cancer
https://www.readbyqxmd.com/read/29110842/patient-reported-outcome-measures-proms-in-the-management-of-lung-cancer-a-systematic-review
#20
REVIEW
Youssef Ben Bouazza, Ibrahim Chiairi, Ouiam El Kharbouchi, Lesley De Backer, Greetje Vanhoutte, Annelies Janssens, Jan P Van Meerbeeck
Lung cancer is often associated with a poor quality of life, as reflected by patient-reported outcome measures (PROMs). The aim of this paper is to describe and compare the PROMs that are available. In this manuscript, we review the impact of PROMs on the management of lung cancer. Quality of the study and risk of bias were assessed using the appraisal tools recommended by the Dutch Cochrane Center. Out of 51 studies included in this review, ten instruments were identified and categorized as either generic, cancer- or lung cancer-specific...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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