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https://www.readbyqxmd.com/read/29776482/does-pain-intensity-matter-the-relation-between-coping-and-quality-of-life-in-pediatric-patients-with-chronic-pain
#1
Alexis K Yetwin, Nicole E Mahrer, Cindy John, Jeffrey I Gold
PURPOSE: Chronic pain is a complex and debilitating chronic health condition that negatively impacts a child's daily function. Previous investigations of coping behaviors in youth with chronic illness have suggested that secondary control/accommodative coping may be more adaptive than primary control/active coping or disengagement/passive coping. However, studies have not considered how pain intensity may change the effect of various coping strategies on functioning in this pediatric population...
May 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29775924/public-project-success-as-seen-in-a-broad-perspective-lessons-from-a-meta-evaluation-of-20-infrastructure-projects-in-norway
#2
Gro Holst Volden
Infrastructure projects in developed countries are rarely evaluated ex-post. Despite their number and scope, our knowledge about their various impacts is surprisingly limited. The paper argues that such projects must be assessed in a broad perspective that includes both operational, tactical and strategic aspects, and unintended as well as intended effects. A generic six-criteria evaluation framework is suggested, inspired by a framework frequently used to evaluate development assistance projects. It is tested on 20 Norwegian projects from various sectors (transport, defence, ICT, buildings)...
April 30, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29774794/health-related-quality-of-life-after-restorative-proctocolectomy-a-cross-sectional-study
#3
I Helavirta, M Hyöty, P Oksanen, H Huhtala, J Haapamäki, P Aitola
BACKGROUND AND AIMS: Patients undergoing restorative proctocolectomy have often suffered from active ulcerative colitis which should be remembered when assessing quality of life after operation. The aim of this study was to explore health-related quality of life after restorative proctocolectomy in those with poor or good pouch function and to compare that to patients with active or inactive ulcerative colitis and to the general population. MATERIAL AND METHODS: Altogether, 282 restorative proctocolectomy patients were investigated...
May 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29774560/high-resolution-separation-of-monoclonal-antibodies-mixtures-and-their-charge-variants-by-an-alternative-and-generic-cze-method
#4
Alexandre Goyon, Yannis Nicolas Francois, Olivier Colas, Alain Beck, Jean Luc Veuthey, Davy Guillarme
The determination of mAb critical quality attributes (CQA) is crucial for their successful application in health diseases. A generic CZE method was developed for the high-resolution separation of various mAb charge variants, which are often recognized as important CQA. A dynamic coating of the capillary was obtained with polyethylene oxide (PEO), whereas Bis-Tris allowed the analysis of mAbs under native conditions at pH 7.0. The effect of PEO and Bis-Tris concentrations, as well as the nature of the acidic counter ion on the method performance were systematically studied...
May 17, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29774207/overview-of-social-cognitive-dysfunctions-in-rare-developmental-syndromes-with-psychiatric-phenotype
#5
REVIEW
Aurore Morel, Elodie Peyroux, Arnaud Leleu, Emilie Favre, Nicolas Franck, Caroline Demily
Rare neurodevelopmental syndromes often present social cognitive deficits that may underlie difficulties in social interactions and increase the risk of psychosis or autism spectrum disorders. However, little is known regarding the specificities of social cognitive impairment across syndromes while it remains a major challenge for the care. Our review provides an overview of social cognitive dysfunctions in rare diseases associated with psychiatric symptoms (with a prevalence estimated between 1 in 1,200 and 1 in 25,000 live births: 22q11...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29773954/pain-catastrophizing-is-associated-with-poorer-health-related-quality-of-life-in-pediatric-patients-with-sickle-cell-disease
#6
Nitya Bakshi, Ines Lukombo, Inna Belfer, Lakshmanan Krishnamurti
Background: Sickle cell disease (SCD) is an inherited disorder of the red blood cells and is associated with chronic multisystem involvement. While SCD has been associated with poorer health-related quality of life (HRQoL), there is a paucity of data on the relationship of psychological covariates other than anxiety and depression and quality of life (QoL) in children with SCD. Materials and methods: We performed a cross-sectional study of psychological factors, HRQoL, and pain-related outcomes in participants with SCD and race-matched controls as part of a larger study of experimental pain phenotyping...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29773292/health-related-quality-of-life-measurement-in-patients-with-chronic-respiratory-failure
#7
REVIEW
Toru Oga, Wolfram Windisch, Tomohiro Handa, Toyohiro Hirai, Kazuo Chin
The improvement of health-related quality of life (HRQL) is an important goal in managing patients with chronic respiratory failure (CRF) receiving long-term oxygen therapy (LTOT) and/or domiciliary noninvasive ventilation (NIV). Two condition-specific HRQL questionnaires have been developed to specifically assess these patients: the Maugeri Respiratory Failure Questionnaire (MRF) and the Severe Respiratory Insufficiency Questionnaire (SRI). The MRF is more advantageous in its ease of completion; conversely, the SRI measures diversified health impairments more multi-dimensionally and discriminatively with greater balance, especially in patients receiving NIV...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29771202/analysing-healthcare-coordination-using-translational-mobilization
#8
Davina Allen
Purpose The purpose of this paper is to introduce translational mobilization theory (TMT) and explore its application for healthcare quality improvement purposes. Design/methodology/approach TMT is a generic sociological theory that explains how projects of collective action are progressed in complex organizational contexts. This paper introduces TMT, outlines its ontological assumptions and core components, and explores its potential value for quality improvement using rescue trajectories as an illustrative case...
May 21, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29769386/global-acceptance-of-biosimilars-importance-of-regulatory-consistency-education-and-trust
#9
REVIEW
Eduardo Cazap, Ira Jacobs, Ali McBride, Robert Popovian, Karol Sikora
Globally, biosimilars are expected to have a key role in improving patient access to biological therapies and addressing concerns regarding the escalating cost of health care. Indeed, in Europe, increased use of biologics and reduced drug prices have been observed after the introduction of biosimilars. Recently, several monoclonal antibody biosimilars of anticancer therapies have been approved, and numerous others are in various stages of clinical development. Biosimilars are authorized via a regulatory pathway separate from that used for generic drugs; they are also regulated separately from novel biologics...
May 16, 2018: Oncologist
https://www.readbyqxmd.com/read/29764325/responsiveness-of-the-eq-5d-3l-in-elective-shoulder-surgery-does-it-adequately-represent-patient-experience
#10
J Evans, Rupen Dattani, Vijayaraj Ramasamy, Vipul Patel
AIM: Generic patient-reported outcome measures (PROMs) allow comparison of health-related quality of life across populations and pathologies. For these comparisons to be valid, the PROM must be responsive; the score must change when the patient's quality of life changes. This study aims to assess the responsiveness of the EQ-5D-three level (3L) in elective shoulder surgery. METHODS: Pre- and post-operative EQ-5D-3L and Oxford Shoulder Scores (OSS) were prospectively collected across a range of 204 elective shoulder surgeries...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29758992/risk-based-data-monitoring-quality-control-in-central-nervous-system-cns-clinical-trials
#11
Cynthia McNamara, Nina Engelhardt, William Potter, Christian Yavorsky, Matthew Masotti, Guillermo Di Clemente
Monitoring the quality of clinical trial efficacy outcome data has received increased attention in the past decade, with regulatory guidance encouraging it to be conducted proactively, and remotely. However, the methods utilized to develop and implement risk-based data monitoring (RBDM) programs vary, and there is a dearth of published material to guide these processes in the context of central nervous system (CNS) trials. We reviewed regulatory guidance published within the past 6 years, generic white papers, and studies applying RBDM to data from CNS clinical trials...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29758606/consistency-properties-of-chaotic-systems-driven-by-time-delayed-feedback
#12
T Jüngling, M C Soriano, N Oliver, X Porte, I Fischer
Consistency refers to the property of an externally driven dynamical system to respond in similar ways to similar inputs. In a delay system, the delayed feedback can be considered as an external drive to the undelayed subsystem. We analyze the degree of consistency in a generic chaotic system with delayed feedback by means of the auxiliary system approach. In this scheme an identical copy of the nonlinear node is driven by exactly the same signal as the original, allowing us to verify complete consistency via complete synchronization...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29755116/health-related-quality-of-life-after-treatment-for-bladder-cancer-in-england
#13
Samantha J Mason, Amy Downing, Penny Wright, Luke Hounsome, Sarah E Bottomley, Jessica Corner, Mike Richards, James W Catto, Adam W Glaser
BACKGROUND: Little is known about quality of life after bladder cancer treatment. This common cancer is managed using treatments that can affect urinary, sexual and bowel function. METHODS: To understand quality of life and inform future care, the Department of Health (England) surveyed adults surviving bladder cancer 1-5 years after diagnosis. Questions related to disease status, co-existing conditions, generic health (EQ-5D), cancer-generic (Social Difficulties Inventory) and cancer-specific outcomes (Functional Assessment of Cancer Therapy-Bladder)...
May 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29754950/oral-health-related-quality-of-life-in-primary-sj%C3%A3-gren-s-syndrome
#14
Gladyz Fernández-Martínez, Víctor Zamora-Legoff, Gabriela Hernández Molina
OBJECTIVE: To assess health-related quality of life (HRQoL) and oral health-related quality of life, and correlate them with unstimulated whole salivary flow (UWSF) and oral sicca symptoms in patients with primary Sjögren's syndrome (PSS). METHODS: We included 60 patients with PSS and 60 healthy controls matched according to gender and age (±3 years). We measured the UWSF and scored the European League Against Rheumatism (EULAR) Sjögren's Syndrome Patient Reported Index (ESSPRI)...
May 10, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29754017/reparaci%C3%A3-n-endovascular-para-aneurisma-de-aorta-revisi%C3%A3-n-panor%C3%A3-mica-sobre-su-evidencia-en-el-mundo-y-su-aplicaci%C3%A3-n-en-latinoam%C3%A3-rica
#15
María Calderón, Viviana Brito, Andrea Alcaraz, Lucila Rey-Ares, Federico Augustovski, Sebastián García-Martí, Ariel Bardach, Agustín Ciapponi, Analía López, Andrés Pichón-Riviere
BACKGROUND: Aortic aneurysm (AA) is a pathology with high morbidity and mortality. The management can be expectant, surgical, or through endovascular repair (EVAR). In Latin America the incidence of AA has increased and the analysis of therapeutic options, especially if they are expensive, is fundamental. OBJECTIVE: To analyze available evidence on the effectiveness, safety and coverage policies of the EVAR. METHODOLOGY: Panoramic review in the main bibliographical bases (MEDLINE, LILACS, EMBASE, Cochrane Library, DARE) and generic internet searchers, main health technology assessment (HTA) agencies and health insurance companies...
May 10, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29751441/assessment-of-urban-green-space-structures-and-their-quality-from-a-multidimensional-perspective
#16
Benjamin Daniels, Barbara S Zaunbrecher, Bastian Paas, Richard Ottermanns, Martina Ziefle, Martina Roß-Nickoll
Facing the growing amount of people living in cities and, at the same time, the need for a compact and sustainable urban development to mitigate urban sprawl, it becomes increasingly important that green spaces in compact cities are designed to meet the various needs within an urban environment. Urban green spaces have a multitude of functions: Maintaining ecological processes and resulting services, e.g. providing habitat for animals and plants, providing a beneficial city microclimate as well as recreational space for citizens...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29746963/patient-phenotypes-associated-with-outcome-following-surgery-for-mild-degenerative-cervical-myelopathy-a-principal-component-regression-analysis
#17
Jetan H Badhiwala, Christopher Witiw, Farshad Nassiri, Blessing Jaja, Muhammad A Akbar, Alireza Mansouri, Zamir Merali, George M Ibrahim, Jefferson R Wilson, Michael G Fehlings
BACKGROUND CONTEXT: Predictors of outcome after surgery for degenerative cervical myelopathy (DCM) have been determined previously through hypothesis-driven multivariate statistical models that rely on a priori knowledge of potential confounders, exclude potentially important variables due to restrictions in model building, cannot include highly collinear variables in the same model, and ignore intrinsic correlations among variables. PURPOSE: To apply a data-driven approach to identify patient phenotypes that may predict outcomes after surgery for mild DCM...
May 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29744792/development-and-psychometrics-of-a-short-form-pharmaceutical-care-specific-measure-for-quality-of-life
#18
Phantipa Sakthong, Nontapat Sonsa-Ardjit, Pattarin Sukarnjanaset, Wipaporn Munpan, Todsaporn Sangthonganotai
Background The validated patient-reported outcomes measure of pharmaceutical therapy for quality of life (PROMPT-QoL) contains 43-items, and can be too lengthy for some applications. Objectives To develop a brief version called the PROMPT, and test its psychometric properties. Setting Four public hospitals in Bangkok, Thailand. Method Secondary analysis of three databases used to develop and evaluate the original PROMPT-QoL. Items for the short-form PROMPT were selected based on expert and patient evaluations of content and importance, and lack of redundancy...
May 9, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29743075/clinical-grade-generation-of-peptide-stimulated-cmv-ebv-specific-t-cells-from-g-csf-mobilized-stem-cell-grafts
#19
Regina Gary, Michael Aigner, Stephanie Moi, Stefanie Schaffer, Anja Gottmann, Stefanie Maas, Robert Zimmermann, Jürgen Zingsem, Julian Strobel, Andreas Mackensen, Josef Mautner, Andreas Moosmann, Armin Gerbitz
BACKGROUND: A major complication after allogeneic hematopoietic stem cell transplantation (aSCT) is the reactivation of herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). Both viruses cause significant mortality and compromise quality of life after aSCT. Preventive transfer of virus-specific T cells can suppress reactivation by re-establishing functional antiviral immune responses in immunocompromised hosts. METHODS: We have developed a good manufacturing practice protocol to generate CMV/EBV-peptide-stimulated T cells from leukapheresis products of G-CSF mobilized and non-mobilized donors...
May 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29742934/drug-information-association-pharmacovigilance-and-risk-management-strategies-2017-overview-of-the-generic-drug-program-and-surveillance
#20
Howard D Chazin, John R Peters, Debra M Catterson, James L Osterhout, Linda M Forsyth, Jung E Lee, Edward K Kim, Karen B Feibus
The US Food and Drug Administration's (FDA's) generic drug program has dramatically increased the availability of affordable, high quality generic drugs. The foundation of generic drug approvals is a two-tiered regulatory framework of pharmaceutical equivalence and bioequivalence. Intrinsic to both of these is consideration of the clinical relevance of formulation and bioequivalence data to support an inference of therapeutic equivalence, based on clear evidence that there are no significant differences between the generic drug and the brand name drug...
January 1, 2018: Therapeutic Innovation & Regulatory Science
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