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cordyceps sinensis

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https://www.readbyqxmd.com/read/28046129/isolation-culture-and-characterization-of-hirsutella-sinensis-mycelium-from-caterpillar-fungus-fruiting-body
#1
Yun-Fei Ko, Jian-Ching Liau, Chien-Sheng Lee, Chen-Yaw Chiu, Jan Martel, Chuan-Sheng Lin, Shun-Fu Tseng, David M Ojcius, Chia-Chen Lu, Hsin-Chih Lai, John D Young
The caterpillar fungus Ophiocordyceps sinensis (previously called Cordyceps sinensis) has been used for centuries in Asia as a tonic to improve health and longevity. Recent studies show that O. sinensis produces a wide range of biological effects on cells, laboratory animals and humans, including anti-fatigue, anti-infection, anti-inflammatory, antioxidant, and anti-tumor activities. In view of the rarity of O. sinensis fruiting bodies in nature, cultivation of its anamorph mycelium represents a useful alternative for large-scale production...
2017: PloS One
https://www.readbyqxmd.com/read/28008812/anti-inflammation-properties-of-fruiting-bodies-and-submerged-cultured-mycelia-of-culinary-medicinal-higher-basidiomycetes-mushrooms
#2
Rao-Chi Chien, Lan-Min Lin, Yuan-Hua Chang, Yu-Chieh Lin, Pei-Hsuan Wu, Mikheil D Asatiani, Sophie-Gabrielle Wasser, Maxim Krakhmalnyi, Abed Agbarya, Solomon P Wasser, Jeng-Leun Mau
This research shows the phenolic composition and anti-inflammation properties of fruiting bodies and mycelia of 15 strains of 12 species of higher Basidiomycetes medicinal mushrooms. In this research, 15 extracts were prepared and their effects on inflammation-related mediators in RAW 264.7 cells were evaluated. In the extracts, amounts of total phenols ranged from 8.47 to 70.32 gallic acid equivalents mg/g and amounts of flavonoids ranged from 0.13 to 15.21 rutin equivalents mg/g. The production of nitric oxide, tumor necrosis factor-α, and interleukin-6 was decreased at different levels by these extracts, whereas the production of interleukin-10 was increased by 6 of the extracts...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27874103/cordyceps-collected-from-bhutan-an-appropriate-alternative-of-cordyceps-sinensis
#3
Ding-Tao Wu, Guang-Ping Lv, Jian Zheng, Qian Li, Shuang-Cheng Ma, Shao-Ping Li, Jing Zhao
Natural Cordyceps collected in Bhutan has been widely used as natural Cordyceps sinensis, an official species of Cordyceps used as Chinese medicines, around the world in recent years. However, whether Cordyceps from Bhutan could be really used as natural C. sinensis remains unknown. Therefore, DNA sequence, bioactive components including nucleosides and polysaccharides in twelve batches of Cordyceps from Bhutan were firstly investigated, and compared with natural C. sinensis. Results showed that the fungus of Cordyceps from Bhutan was C...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27723567/identification-of-chinese-medicinal-fungus-cordyceps-sinensis-by-depth-profiling-mid-infrared-photoacoustic-spectroscopy
#4
Changwen Du, Jianmin Zhou, Jianfeng Liu
With increased demand for Cordyceps sinensis it needs rapid methods to meet the challenge of identification raised in quality control. In this study Cordyceps sinensis from four typical natural habitats in China was characterized by depth-profiling Fourier transform infrared photoacoustic spectroscopy. Results demonstrated that Cordyceps sinensis samples resulted in typical photoacoustic spectral appearance, but heterogeneity was sensed in the whole sample; due to the heterogeneity Cordyceps sinensis was represented by spectra of four groups including head, body, tail and leaf under a moving mirror velocity of 0...
February 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27721890/dual-directional-immunomodulatory-effects-of-corbrin-capsule-on-autoimmune-thyroid-diseases
#5
Tianyi He, Ruxing Zhao, Yiran Lu, Wenjuan Li, Xinguo Hou, Yu Sun, Ming Dong, Li Chen
Purpose. To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived from Cordyceps sinensis (Berk.) Sacc., on autoimmune thyroid diseases (AITD). Methods. 44 Patients with Graves's disease (GD) and 56 patients with Hashimoto's thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same conventional prescriptions as control groups...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27689974/cordycepin-induces-apoptosis-and-inhibits-proliferation-of-human-lung-cancer-cell-line-h1975-via-inhibiting-the-phosphorylation-of-egfr
#6
Zheng Wang, Xue Wu, Yan-Ni Liang, Li Wang, Zhong-Xing Song, Jian-Li Liu, Zhi-Shu Tang
Cordycepin is an active component of the traditional Chinese medicine Cordyceps sinensis and Cordyceps militaris with notable anticancer activity. Though the prominent inhibitory activity was reported in different kinds of cancer cell lines, the concrete mechanisms remain elusive. It was reported that cordycepin could be converted into tri-phosphates in vivo to confuse a number of enzymes and interfere the normal cell function. For the inhibitory mechanism of EGFR inhibitors and the structure similarity of ATP and tri-phosphated cordycepin, human lung cancer cell line H1975 was employed to investigate the inhibitory effect of cordycepin...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27625176/high-throughput-sequencing-based-analysis-of-endogenetic-fungal-communities-inhabiting-the-chinese-cordyceps-reveals-unexpectedly-high-fungal-diversity
#7
Fei Xia, Xin Chen, Meng-Yuan Guo, Xiao-Hui Bai, Yan Liu, Guang-Rong Shen, Yu-Ling Li, Juan Lin, Xuan-Wei Zhou
Chinese Cordyceps, known in Chinese as "DongChong XiaCao", is a parasitic complex of a fungus (Ophiocordyceps sinensis) and a caterpillar. The current study explored the endogenetic fungal communities inhabiting Chinese Cordyceps. Samples were collected from five different geographical regions of Qinghai and Tibet, and the nuclear ribosomal internal transcribed spacer-1 sequences from each sample were obtained using Illumina high-throughput sequencing. The results showed that Ascomycota was the dominant fungal phylum in Chinese Cordyceps and its soil microhabitat from different sampling regions...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27555762/the-inhibitory-mechanism-of-cordyceps-sinensis-on-cigarette-smoke-extract-induced-senescence-in-human-bronchial-epithelial-cells
#8
Ailing Liu, Jinxiang Wu, Aijun Li, Wenxiang Bi, Tian Liu, Liuzhao Cao, Yahui Liu, Liang Dong
OBJECTIVES: Cellular senescence is a state of irreversible growth arrest induced either by telomere shortening (replicative senescence) or stress. The bronchial epithelial cell is often injured by inhaled toxic substances, such as cigarette smoke. In the present study, we investigated whether exposure to cigarette smoke extract (CSE) induces senescence of bronchial epithelial cells; and Cordyceps sinensis mechanism of inhibition of CSE-induced cellular senescence. METHODS: Human bronchial epithelial cells (16HBE cells) cultured in vitro were treated with CSE and/or C...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27531890/systematic-revelation-of-the-protective-effect-and-mechanism-of-cordycep-sinensis-on-diethylnitrosamine-induced-rat-hepatocellular-carcinoma-with-proteomics
#9
Pei-Wen Wang, Yu-Chiang Hung, Wen-Tai Li, Chau-Ting Yeh, Tai-Long Pan
Cordyceps sinensis (C. sinensis) has been reported to treat liver diseases. Here, we investigated the inhibitory effect of C. sinensis on hepatocarcinoma in a diethylnitrosamine (DEN)-induced rat model with functional proteome tools.In the DEN-exposed group, levels of serum alanine aminotransferase and aspartate aminotransferase were increased while C. sinensis application remarkably inhibited the activities of these enzymes. Histopathological analysis also indicated that C. sinensis could substantially restore hypertrophic hepatocytes caused by DEN, suggesting that C...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27514485/microwave-assisted-extraction-chemical-structures-and-chain-conformation-of-polysaccharides-from-a-novel-cordyceps-sinensis-fungus-um01
#10
Kit-Leong Cheong, Lan-Ying Wang, Ding-Tao Wu, De-Jun Hu, Jing Zhao, Shao-Ping Li
Cordyceps sinensis is a well-known tonic food with broad medicinal properties. The aim of the present study was to investigate the optimization of microwave-assisted extraction (MAE) and characterize chemical structures and chain conformation of polysaccharides from a novel C. sinensis fungus UM01. Ion-exchange and gel filtration chromatography were used to purify the polysaccharides. The chemical structure of purified polysaccharide was determined through gas chromatography-mass spectrometry. Moreover, high performance size exclusion chromatography combined with refractive index detector and multiangle laser light scattering were conducted to analyze the molecular weight (Mw ) and chain conformation of purified polysaccharide...
September 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27511742/a-double-blind-randomised-placebo-controlled-trial-of-ganoderma-lucidum-for-the-treatment-of-cardiovascular-risk-factors-of-metabolic-syndrome
#11
Nerida L Klupp, Hosen Kiat, Alan Bensoussan, Genevieve Z Steiner, Dennis H Chang
This study aimed to evaluate the efficacy and safety of Ganoderma lucidum for the treatment of hyperglycaemia and other cardiovascular risk components of metabolic syndrome using a prospective, double-blind, randomised, placebo-controlled trial. Eighty-four participants with type 2 diabetes mellitus and metabolic syndrome were randomised to one of three intervention groups: Ganoderma lucidum, Ganoderma lucidum with Cordyceps sinensis, or placebo. The dosage was 3 g/day of Ganoderma lucidum, with or without Cordyceps sinensis, for 16 weeks...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27496606/enhancement-of-cordyceps-polysaccharide-production-via-biosynthetic-pathway-analysis-in-hirsutella-sinensis
#12
Shan Lin, Zhi-Qiang Liu, Peter James Baker, Ming Yi, Hui Wu, Feng Xu, Yi Teng, Yu-Guo Zheng
The addition of various sulfates for enhanced cordyceps polysaccharide (CP) production in submerged cultivation of H. sinensis was investigated, and manganese sulfate was found the most effective. 2mM of manganese sulfate on 0day (d) was investigated as the optimal adding condition, and the CP production reached optimum with 5.33%, increasing by 93.3% compared with the control. Furthermore, the consumption of three main precursors of CP was studied over cultivation under two conditions. Intracellular mannose content decreased by 43...
November 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27449560/improved-biological-activities-of-isoepoxypteryxin-by-biotransformation
#13
Amira Mira, Wael Alkhiary, Qinchang Zhu, Toshinori Nakagawa, Hai-Bang Tran, Yhiya M Amen, Kuniyoshi Shimizu
Isoepoxypteryxin is the major coumarin of a Japanese medicinal plant Angelica shikokiana. This research was designed to study the effect of structural changes through fungal biotransformation on the reported biological activities of isoepoxypteryxin. Among the tested microorganisms, only Cordyceps sinensis had enzymes that could catalyze the ester hydrolysis and the reductive cleavage of the epoxide ring of isoepoxypteryxin, separately, to give two more polar metabolites (+)-cis-khellactone (P1) and a new coumarin derivative (+)-cis-3'-[(2-methyl-3-hydroxybutanoyl)oxy]-4'-acetoxy-3',4'-dihydroseselin (P2), respectively...
October 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27446383/cordycepin-induces-apoptosis-in-human-liver-cancer-hepg2-cells-through-extrinsic-and-intrinsic-signaling-pathways
#14
Le-Wen Shao, Li-Hua Huang, Sheng Yan, Jian-Di Jin, Shao-Yan Ren
Cordycepin, also termed 3'-deoxyadenosine, is a nucleoside analogue from Cordyceps sinensis and has been reported to demonstrate numerous biological and pharmacological properties. Our previous study illustrated that the anti-tumor effect of cordycepin may be associated with apoptosis. In the present study, the apoptotic effect of cordycepin on HepG2 cells was investigated using 4',6-diamidino-2-phenylindole, tetraethylbenzimidazolylcarbocyanine iodide and propidium iodide staining analysis and flow cytometry...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27444351/mhp-1-inhibits-cancer-metastasis-and-restores-topotecan-sensitivity-via-regulating-epithelial-mesenchymal-transition-and-tgf-%C3%AE-signaling-in-human-breast-cancer-cells
#15
Sensen Lin, Xiaodan Lyu, Jun Yu, Li Sun, Danyu Du, Yanqi Lai, Hongyang Li, Ying Wang, Luyong Zhang, Hongping Yin, Shengtao Yuan
BACKGROUND: Cordyceps has long been used to treat cancer. However, its pharmacologically active components as well as the molecular mechanisms underlying its effects are still unclear. PURPOSE: To investigate the effect of MHP-1, a newly isolated polysaccharide from Mortierella hepialid (the asexual structure of C. sinensis), on breast cancer metastasis. STUDY DESIGN: The effect of MHP-1 on breast cancer cell migration, epithelial-mesenchymal transition (EMT) and TGF-β signaling were investigated in vitro and in vivo...
September 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27433838/cordyceps-sinensis-genotoxic-potential-in-human-peripheral-blood-cells-and-antigenotoxic-properties-against-hydrogen-peroxide-by-comet-assay
#16
Jovana D Vasiljevic, Lada P Zivkovic, Andrea M Cabarkapa, Vladan P Bajic, Ninoslav J Djelic, Biljana M Spremo-Potparevic
Context • Cordyceps sinensis (C sinensis) is a well-known, traditional, Chinese medicinal mushroom, valued for its beneficial properties for human health. C sinensis has been reported to have immunomodulatory, anticancer, antiaging, antioxidant and anti-inflammatory activity. Despite potential medicinal benefits, no previously published reports are available about the genotoxicity or antigenotoxicity of C sinensis, as detected by comet assay. Objective • The objective of the study was to evaluate both the genotoxic and antigenotoxic potential of an extract of C sinensis (CS extract) in human peripheral blood cells...
June 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27389266/draft-genome-sequence-of-paecilomyces-hepiali-isolated-from-cordyceps-sinensis
#17
Yi Yu, Wenting Wang, Linping Wang, Fang Pang, Lanping Guo, Lai Song, Guiming Liu, Chengqiang Feng
Paecilomyces hepiali is an endoparasitic fungus that commonly exists in the natural Cordyceps sinensis Here, we report the draft genome sequence of P. hepiali, which will facilitate the exploitation of medicinal compounds produced by the fungus.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27373780/the-mechanisms-of-pharmacological-activities-of-ophiocordyceps-sinensis-fungi
#18
Jin Xu, Ying Huang, Xiang-Xiang Chen, Shuai-Chao Zheng, Peng Chen, Ming-He Mo
The entomopathogenic fungus Ophiocordyceps sinensis, formerly known as Cordyceps sinensis, has long been used as a traditional Chinese medicine for the treatment of many illnesses. In recent years its usage has increased dramatically because of the improvement of people's living standard and the emphasis on health. Such demands have resulted in over-harvesting of this fungus in the wild. Fortunately, scientists have demonstrated that artificially cultured and fermented mycelial products of O. sinensis have similar pharmacological activities to wild O...
July 3, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27279447/cytological-characterization-of-anamorphic-fungus-lecanicillium-pui-and-its-relationship-with-chinese-caterpillar-mushroom-ophiocordyceps-sinensis-ascomycetes
#19
Wei Lei, Guren Zhang, Guangguo Wu, Xin Liu
Ophiocordyceps sinensis (syn. Cordyceps sinensis), one of the most valuable medicinal mushrooms, has great economic importance on the Tibetan Plateau. We isolated an anamorphic fungus Lecanicillium pui from natural O. sinensis specimens and found that the optimal temperature for its culture on potato dextrose agar media was 25°C. Cell ultrastructure in L. pui hyphae and spores was characterized by transmission electron microscopy, and it was observed that some primary organelles showed the typical fungal features...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27140306/the-herbal-medicine-cordyceps-sinensis-protects-pancreatic-beta-cells-from-streptozotocin-induced-endoplasmic-reticulum-stress
#20
Hong Liu, Diyong Cao, Hua Liu, Xinghai Liu, Wenli Mai, Haitao Lan, Wen Huo, Qian Zheng
OBJECTIVES: Our previous work found that Cordyceps sinensis (CS) improves the activity and secretory function of pancreatic islet beta cells. The objective was to observe a further possible role of CS in the protection of insulin-secreting cells. METHODS: A rat model of type 2 diabetes mellitus was developed with streptozotocin (STZ) and a high-energy fat diet (HFD). CS was administered in the successful model of rats with type 2 diabetes. After 4 weeks, the biochemistry index of blood samples was measured, and pathologic observation was performed by immunohistochemistry...
August 2016: Canadian Journal of Diabetes
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