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cordyceps sinensis

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https://www.readbyqxmd.com/read/29139260/-study-on-distribution-of-five-heavy-metal-elements-in-different-parts-of-cordyceps-sinensis-by-microwave-digestion-icp-ms
#1
Li Zhou, Qing-Xiu Hao, Sheng Wang, Quan Yang, Chuan-Zhi Kang, Wan-Zhen Yang, Lan-Ping Guo
The contents of five heavy metals (Cu, Pb, As, Cd, Hg) in 17 batches of Cordyceps sinensis were determined by microwave digestion-ICP-MS, and their distribution in C. sinensis were analyzed. The results showed that the contents of Cu, Pb, Cd and Hg in all batches were in accordance with the international standards of Chinese Medicine-Chinese Herbal Medicine Heavy Metal Limit, with their contents in the stroma higher than that in the caterpillar body, and the excess rate of As, which mainly concentrated in the caterpillar body part of C...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29124970/a-review-on-the-nucleic-acid-constituents-in-mushrooms-nucleobases-nucleosides-and-nucleotides
#2
Chia-Wei Phan, Joon-Keong Wang, Shiau-Chuen Cheah, Murali Naidu, Pamela David, Vikineswary Sabaratnam
Mushrooms have become increasingly important as a reliable food source. They have also been recognized as an important source of bioactive compounds of high nutritional and medicinal values. The nucleobases, nucleosides and nucleotides found in mushrooms play important roles in the regulation of various physiological processes in the human body via the purinergic and/or pyrimidine receptors. Cordycepin, a 3'-deoxyadenosine found in Cordyceps sinensis has received much attention as it possesses many medicinal values including anticancer properties...
November 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29090553/-simultaneous-determination-of-cordycepin-and-2-deoxyadenosine-in-cordyceps-genus-by-online-spe-hplc
#3
Ye Tian, Chuan-Xi Wang, Zheng-Ming Qian, Zhou Li, Miao-Xia Zhou, Wan-Yang Sun, Xin-Sheng Yao, Wen-Jia Li, Hao Gao
An online SPE-HPLC method for simultaneous determination of cordycepin (3'-deoxyadenosine) and 2'-deoxyadenosine in Cordyceps genus (C. sinensis,C. militaris,Hirsutella sinensis and C. sobolifera) was developed. The samples were enriched on a ZORBAX SB-AQ (4.6 mm×12.5 mm,5 μm) column with isocratic elution by 9% methanol solution. The separation of analytes was performed on a ZORBAX SB-AQ (4.6 mm×150 mm,5 μm) column with gradient elution by 0.1% formic acid solution and methanol (91∶9). The flow rate was 1...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29064460/gc-ms-profiling-of-volatile-components-in-different-fermentation-products-of-cordyceps-sinensis-mycelia
#4
Hongyang Zhang, Yahui Li, Jianing Mi, Min Zhang, Yuerong Wang, Zhihong Jiang, Ping Hu
The fermentation products of Cordyceps sinensis (C. sinensis) mycelia are sustainable substitutes for natural C. sinensis. However, the volatile compositions of the commercial products are still unclear. In this paper, we have developed a simultaneous distillation-extraction (SDE) and gas chromatography-mass spectrometry (GC-MS) method for the profiling of volatile components in five fermentation products. A total of 64, 39, 56, 52, and 44 components were identified in the essential oils of Jinshuibao capsule (JSBC), Bailing capsule (BLC), Zhiling capsule (ZLC), Ningxinbao capsule (NXBC), and Xinganbao capsule (XGBC), respectively...
October 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29052387/-climate-change-impacts-on-yield-of-cordyceps-sinensis-and-research-on-yield-prediction-model-of-c-sinensis
#5
Shou-Dong Zhu, Lu-Qi Huang, Lan-Ping Guo, Xing-Tian Ma, Qing-Xiu Hao, Zhi-Yong Le, Xiao-Bo Zhang, Guang Yang, Yan Zhang, Mei-Lan Chen
Cordyceps sinensis is a Chinese unique precious herbal material, its genuine producing areas covering Naqu, Changdu in Qinghai Tibet Plateau, Yushu in Qinghai province and other regions. In recent 10 years, C. sinensis resources is decreasing as a result of the blindly and excessively perennial dug. How to rationally protect, develop and utilize of the valuable resources of C. sinensis has been referred to an important field of research on C. sinensis. The ecological environment and climate change trend of Qinghai Tibet plateau happens prior to other regions, which means that the distribution and evolution of C...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28937034/effect-of-cordyceps-sinensis-on-the-treatment-of-experimental-autoimmune-encephalomyelitis-a-pilot-study-on-mice-model
#6
Shan-Shan Zhong, Ya-Juan Xiang, Pen-Ju Liu, Yang He, Ting-Ting Yang, Yang-Yang Wang, A Rong, Jun Zhang, Guang-Zhi Liu
BACKGROUND: As a traditional Chinese medicine, Cordyceps sinensis (CS) possesses a variety of immunoregulatory properties. This study aimed to explore the therapeutic potential of CS in a mice model of multiple sclerosis (MS)-experimental autoimmune encephalomyelitis (EAE). METHODS: Female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein35-55to induce EAE, followed by an instant intragastric feeding with a low dosage of CS (low-CS group, n = 5), high dosage of CS (high-CS group, n = 5), or the same volume of normal saline (control group, n = 5)...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28935392/transcriptome-analysis-of-paecilomyces-hepiali-at-different-growth-stages-and-culture-additives-to-reveal-putative-genes-in-cordycepin-biosynthesis
#7
Fang Pang, Linping Wang, Yu Jin, Lanping Guo, Lipu Song, Guiming Liu, Chengqiang Feng
Paecilomyces hepialid (PH) is an endoparasitic fungus of Cordyceps sinensis (CS) and has become a substitute for CS due to their similar pharmacological activities. Because the market demand for CS is difficult to satisfy, and cordycepin, the effective compound of CS, is difficult to industrially produce, we produced 5 samples of PH by culturing for different durations and adding different additives to the culture broth, and detected their cordycepin content with UPLC ESI MS/MS. Then we grouped these cultures into five transcriptome comparisons containing 3 time variable groups and 2 additive variable groups...
September 18, 2017: Genomics
https://www.readbyqxmd.com/read/28929674/-molecular-mechanisms-of-autophagy-in-regulating-renal-aging-and-interventional-effects-of-chinese-herbal-medicine
#8
REVIEW
Yue Tu, Wei Sun, Di-Ping Chen, Yi-Gang Wan, Wei Wu, Jian Yao
Aging is the gradual functional recession of the living tissues or organs caused by a variety of genetic and environmental factors together. Autophagy is a process of degrading cytoplasmic components mediated by lysosomes in eukaryotic cells. Kidney is a typical target organ of aging. Autophagy regulates renal aging. Decrease in autophagy can accelerate renal aging,whereas,increase in autophagy can delay renal aging. During the process of regulating renal aging,the mammalian target of rapamycin (mTOR) and its related signaling pathways including the adenosine monophosphate activated protein kinase (AMPK)/mTOR,the phosphatidylinositol 3-kinase (PI3K)/ serine-threonine kinase(Akt)/mTOR,the AMPK/silent information regulation 1 (Sirt1) and transforming growth factor β (TGF-β) play the important roles in renal aging...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28927020/stable-carbon-isotope-composition-of-the-lipids-in-natural-ophiocordyceps-sinensis-from-major-habitats-in-china-and-its-substitutes
#9
Lian-Xian Guo, Xiao-Ming Xu, Yue-Hui Hong, Yan Li, Jiang-Hai Wang
Ophiocordyceps sinensis is one rare medicinal fungus produced in the Qinghai-Tibetan Plateau. Its quality and price varies hugely with different habitat, and its numerous substitutes have sprung up in functional food markets. This paper aims to discriminate the geographic origin of wild O. sinensis and its substitutes via element analyzer-isotope ratio mass spectrometry and gas chromatography-isotope ratio mass spectrometry. The δ(13)C values of major fatty acids in the lipids of O. sinensis are characterized unanimously by the variation relation C18:0 < C18:2 ≈ C16:0 < C18:1, while their fluctuation intervals are notably different between those of neutral and polar lipids...
September 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28911537/functional-study-of-cordyceps-sinensis-and-cordycepin-in-male-reproduction-a-review
#10
REVIEW
Yung-Chia Chen, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang, Bu-Miin Huang
Cordyceps sinensis has various biological and pharmacological functions, and it has been claimed as a tonic supplement for sexual and reproductive dysfunctions for a long time in oriental society. In this article, the in vitro and in vivo effects of C. sinensis and cordycepin on mouse Leydig cell steroidogenesis are briefly described, the stimulatory mechanisms are summarized, and the recent findings related to the alternative substances regulating male reproductive functions are also discussed.
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28836874/anti-fibrosis-effect-for-hirsutella-sinensis-mycelium-based-on-inhibition-of-mtor-p70s6k-phosphorylation
#11
Huimin Yue, Yarong Zhao, Haining Wang, Feiya Ma, Fei Liu, Sunan Shen, Yayi Hou, Huan Dou
Hirsutella sinensis, cultured in vitro, is an attractive substitute for Cordyceps sinensis as health supplement. The aim of this study was to demonstrate whether H. sinensis mycelium (HSM) attenuates murine pulmonary fibrosis induced by bleomycin and to explore the underlying molecular mechanisms. Using lung fibrosis modle induced by intratracheal instillation of bleomycin (BLM; 4 mg/kg), we observed that the administration of HSM reduced HYP, TGF-β1 and the production of several pro-fibrosis cytokines (α-smooth muscle actin, fibronectin and vimentin) in fibrotic mice lung sections...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28798802/prescribed-renoprotective-chinese-herbal-medicines-were-associated-with-a-lower-risk-of-all-cause-and-disease-specific-mortality-among-patients-with-chronic-kidney-disease-a-population-based-follow-up-study-in-taiwan
#12
Chuan-Fa Hsieh, Huan-Cheng Chang, Song-Lih Huang, Chien-Lung Chen, Wei-Ta Chen, Chen-Chang Yang
Chinese herbal medicines (CHMs) containing aristolochic acid (AA) are associated with chronic kidney disease (CKD), but some prescribed CHMs have been shown to possess renoprotective effects. We conducted a nationwide retrospective cohort study to delineate the role of prescribed CHMs on the CKD progression. Renoprotective CHM (RPCHM) was defined if a CHM contained dong chong xia cao (Cordyceps sinensis (Berk.) Sacc.), da huang (Rheum palmatum L), huang qi (Astragalus membranaceus), dan shen (Salvia miltiorrhiza Bge...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28798416/fungus-larva-relation-in-the-formation-of-cordyceps-sinensis-as-revealed-by-stable-carbon-isotope-analysis
#13
Lian-Xian Guo, Yue-Hui Hong, Qian-Zhi Zhou, Qing Zhu, Xiao-Ming Xu, Jiang-Hai Wang
For more than one thousand years, Cordyceps sinensis has been revered as a unique halidom in the Qinghai-Tibetan Plateau for its mysterious life history and predominant medicinal values. This mysterious fungus-larva symbiote also attracted the over-exploitation, while several problems on the initial colonization of Ophiocordyceps sinensis in the host larva have constrained artificial cultivation. In this work, stable carbon isotope analysis was employed to analyse the subsamples of C. sinensis from 5 representative habitats...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28793052/cordyceps-sinensis-promotes-immune-regulation-and-enhances-bacteriostatic-activity-of-pa-824-via-il-10-in-mycobacterium-tuberculosis-disease
#14
D G Li, Z X Ren
PA-824 is a novel bicyclic nitroimidazole anti-tuberculosis (TB) drug. Cordyceps sinensis (Berk.) Sacc. (CS) was proven to be a good immunomodulatory compound. This research aimed to investigate the effect of CS on PA-824 in Mycobacterium tuberculosis (M.tb) infected mice (female CBA/J mice, 6 to 8 weeks of age and 20±2 g of weight). Mice were randomly assigned to 4 groups: PA-824, CS, PA-824+CS, and control. To verify the effect of PA-824 and CS on M.tb, after drug administration, mice lungs were harvested and bacterial colony formations were measured...
August 7, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28680424/detection-of-ophiocordyceps-sinensis-and-its-common-adulterates-using-species-specific-primers
#15
Yang Liu, Xiao-Yue Wang, Zi-Tong Gao, Jian-Ping Han, Li Xiang
Ophiocordyceps sinensis is a fungus that infects Hepialidae caterpillars, mummifying the larvae and producing characteristic fruiting bodies (stromata) that are processed into one of the most valued traditional Chinese medicines (TCM). The product commands a very high price due to a high demand but a very limited supply. Adulteration with other fungi is a common problem and there is a need to test preparation for the presence of the correct fungus. In the current study, a PCR-based approach for the identification of O...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28636672/metabolomic-profile-and-nucleoside-composition-of-cordyceps-nidus-sp-nov-cordycipitaceae-a-new-source-of-active-compounds
#16
Juan Chiriví, Giovanna Danies, Rocio Sierra, Nicolas Schauer, Sandra Trenkamp, Silvia Restrepo, Tatiana Sanjuan
Cordyceps sensu lato is a genus of arthropod-pathogenic fungi, which have been used traditionally as medicinal in Asia. Within the genus, Ophiocordyceps sinensis is the most coveted and expensive species in China. Nevertheless, harvesting wild specimens has become a challenge given that natural populations of the fungus are decreasing and because large-scale culture of it has not yet been achieved. The worldwide demand for products derived from cultivable fungal species with medicinal properties has increased recently...
2017: PloS One
https://www.readbyqxmd.com/read/28274870/construction-of-a-cordyceps-sinensis-exopolysaccharide-conjugated-selenium-nanoparticles-and-enhancement-of-their-antioxidant-activities
#17
Yidong Xiao, Qilin Huang, Zhaomin Zheng, Han Guan, Shiyu Liu
A Cordyceps sinensis exopolysaccharide (EPS)-conjugated selenium nanoparticles (SeNPs) were successfully constructed through the reduction of SeO3(2-). The EPS-SeNPs were characterized in terms of formation, morphology, size, Se distribution and phase by UV-vis, FT-IR, transmission electron microscopy (TEM), dynamic light scattering (DLS), energy dispersive X-ray (EDX) and wide angle X-ray diffraction (WAXD) measurements. Results revealed that the SeNPs conjugated to EPS were amorphous and could be well dispersed at a size range of 80-125nm...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28267517/effects-of-cultured-cordyceps-mycelia-polysaccharide-a-on-tumor-neurosis-factor-%C3%AE-induced-hepatocyte-injury-with-mitochondrial-abnormality
#18
Huiling Tang, Weikun Wei, Wang Wang, Zhengqi Zha, Ting Li, Zhijie Zhang, Chen Luo, Hongping Yin, Fengjie Huang, Ying Wang
Cordyceps sinensis mycelia polysaccharide A (CPS-A), was isolated from cultured Cordyceps mycelia by 65% alcohol extraction and ion-exchange column chromatography. The molecular weight of CPS-A was 1.2×10(4)Da and the backbone was mainly composed of (1→2)-linked β-d-mannopyranose, (1→2,4)-linked β-d-mannopyranose and (1→4)-linked α-d-glucopyranose with terminal β-d-mannopyranose and α-d-glucopyranose residues. CPS-A played a protective role against TNF-α induced mitochondria injury in L02 cells via up-regulation of mitofusin 2, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and membrane potential...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28250651/analysis-of-soluble-proteins-in-natural-cordyceps-sinensis-from-different-producing-areas-by-sodium-dodecyl-sulfate-polyacrylamide-gel-electrophoresis-and-two-dimensional-electrophoresis
#19
Chun-Hong Li, Hua-Li Zuo, Qian Zhang, Feng-Qin Wang, Yuan-Jia Hu, Zheng-Ming Qian, Wen-Jia Li, Zhi-Ning Xia, Feng-Qing Yang
BACKGROUND: As one of the bioactive components in Cordyceps sinensis (CS), proteins were rarely used as index components to study the correlation between the protein components and producing areas of natural CS. OBJECTIVE: Protein components of 26 natural CS samples produced in Qinghai, Tibet, and Sichuan provinces were analyzed and compared to investigate the relationship among 26 different producing areas. MATERIALS AND METHODS: Proteins from 26 different producing areas were extracted by Tris-HCl buffer with Triton X-100, and separated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and two-dimensional electrophoresis (2-DE)...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28217148/profiling-metals-in-cordyceps-sinensis-by-using-inductively-coupled-plasma-mass-spectrometry
#20
Xin Wei, Hankun Hu, Baogeng Zheng, Zikri Arslan, Hung-Chung Huang, Weidong Mao, Yi-Ming Liu
Cordyceps sinensis (C. sinensis) is a natural product that has diverse nutritional and medicinal values. Since the availability of natural C. sinensis becomes limited its authentication and quality control is of high significance. Herein we report on profiling of metals in C. sinensis by using inductively coupled plasma mass spectrometry (ICP-MS). The analysis reveals that C. sinensis contains a wide array of essential elements, including P, Mg, Zn, Cu, Fe, etc. Toxic metals detected are Cd, Pb, and As. In all five samples analyzed Pb contents are below 2...
January 28, 2017: Analytical Methods: Advancing Methods and Applications
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