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https://www.readbyqxmd.com/read/29777833/endocrine-disrupting-activities-and-immunomodulatory-effects-in-lymphoblastoid-cell-lines-of-diclofenac-4-hydroxydiclofenac-and-paracetamol
#1
Ivana Klopčič, Tijana Markovič, Irena Mlinarič-Raščan, Marija Sollner Dolenc
A critical literature review reveals that knowledge of side effects of pharmaceuticals diclofenac and paracetamol is extremely important because of their widespread use and occurrence in the environment. In order to delineate whether these compounds have endocrine activity and influence on the immune system, we assessed the potential endocrine disrupting and immunomodulatory activities of: diclofenac (DIC), its metabolite 4-hydroxydiclofenac (4-HD) and paracetamol (PAR). Herein, we report on their impact on estrogen receptor (ER), androgen receptor (AR), glucocorticoid receptor (GR) and thyroid hormone receptor (TR)...
May 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29777601/-informed-consent-something-unresolved-in-the-penitentiary-setting
#2
Julio García Guerrero
INTRODUCTION: The exercise of Informed Consent within the penitentiary environment contradicts the ordinary exercise of the same towards the rest of the population. METHODOLOGY: review of legal regulations and constitutional doctrine on IC. Review of the judicial outcomes when a prisoner refuses medical treatment. RESULTS: Normative on IC (Ley 41/2002 y Convenio de Oviedo, Spanish legal framework): with the exception of cases in which IC cannot be taken or under the risk of causong damage to third parties, competent and capable persons can decide over their life and health, and such decisions need to be respected...
May 2018: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/29775713/enhancement-of-catalytic-activity-and-thermostability-of-a-thermostable-cellobiohydrolase-from-chaetomium-thermophilum-by-site-directed-mutagenesis
#3
Chao Han, Weiguang Li, Chengyao Hua, Fengqing Sun, Pengsheng Bi, Qunqing Wang
Enzymatic saccharification of lignocellulosic biomass is increasingly applied in agricultural and industrial applications. Nevertheless, low performance in the extreme environment severely prevents the utilization of commercial enzyme preparations. To obtain cellobiohydrolases with improved catalytic activity and thermostability, structure-based rational design was performed based on a thermostable cellobiohydrolase CtCel6 from Chaetomium thermophilum. In the present study, four conserved and noncatalytic residue substitutions were generated via site-directed mutagenesis...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29774975/signals-of-large-scale-climate-drivers-hatchery-enhancement-and-marine-factors-in-yukon-river-chinook-salmon-survival-revealed-with-a-bayesian-life-history-model
#4
Curry J Cunningham, Peter A H Westley, Milo D Adkison
Understanding how species might respond to climate change involves disentangling the influence of co-occurring environmental factors on population dynamics, and is especially problematic for migratory species like Pacific salmon that move between ecosystems. To date, debate surrounding the causes of recent declines in Yukon River Chinook salmon (Oncorhynchus tshawytscha) abundance has centered on whether factors in freshwater or marine environments control variation in survival, and how these populations at the northern extremity of the species range will respond to climate change...
May 18, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29773961/an-example-of-aerosol-pattern-variability-over-bright-surface-using-high-resolution-modis-maiac-the-eastern-and-western-areas-of-the-dead-sea-and-environs
#5
Sever Lee, Alpert Pinhas, Lyapustin Alexei, Wang Yujie, Chudnovsky A Alexandra
The extreme rate of evaporation of the Dead Sea (DS) has serious implicatios for the surrounding area, including atmospheric conditions. This study analyzes the aerosol properties over the western and eastern parts of the DS during the year 2013, using MAIAC (Multi-Angle Implementation of Atmospheric Correction) for MODIS, which retrieves aerosol optical depth (AOD) data at a resolution of 1km. The main goal of the study is to evaluate MAIAC over the study area and determine, for the first time, the prevailing aerosol spatial patterns...
September 2017: Atmospheric Environment
https://www.readbyqxmd.com/read/29773926/comparative-analysis-of-airborne-bacteria-and-fungi-in-two-salt-mines-in-poland
#6
Elżbieta Gębarowska, Wojciech Pusz, Jolanta Kucińska, Włodzimierz Kita
The aim of this work was to determine the genera or species composition and the number of colony forming units of airborne bacteria and fungi, respectively, in two salt mines in Poland "Wieliczka" (Lesser Poland) and "Polkowice-Sieroszowice" (Lower Silesia). Both of them are working environments characterized by extreme conditions, and additionally "Wieliczka," officially placed on the UNESCO World Heritage Sites' list, plays a role of tourist attraction. There are also some curative chambers located in this mine...
2018: Aerobiologia
https://www.readbyqxmd.com/read/29773745/prospects-for-harnessing-biocide-resistance-for-bioremediation-and-detoxification
#7
REVIEW
Siavash Atashgahi, Irene Sánchez-Andrea, Hermann J Heipieper, Jan R van der Meer, Alfons J M Stams, Hauke Smidt
Prokaryotes in natural environments respond rapidly to high concentrations of chemicals and physical stresses. Exposure to anthropogenic toxic substances-such as oil, chlorinated solvents, or antibiotics-favors the evolution of resistant phenotypes, some of which can use contaminants as an exclusive carbon source or as electron donors and acceptors. Microorganisms similarly adapt to extreme pH, metal, or osmotic stress. The metabolic plasticity of prokaryotes can thus be harnessed for bioremediation and can be exploited in a variety of ways, ranging from stimulated natural attenuation to bioaugmentation and from wastewater treatment to habitat restoration...
May 18, 2018: Science
https://www.readbyqxmd.com/read/29773581/dynamic-changes-between-two-lhcx-related-energy-quenching-sites-control-diatom-photoacclimation
#8
Lucilla Taddei, Volha Chukhutsina, Bernard Lepetit, Giulio R Stella, Roberto Bassi, Herbert van Amerongen, Jean-Pierre Bouly, Marianne Jaubert, Giovanni Finazzi, Angela Falciatore
Marine diatoms are prominent phytoplankton organisms, optimally performing photosynthesis in extremely variable environments. Diatoms possess a strong ability to dissipate excess absorbed energy as heat via non-photochemical quenching (NPQ). This process relies on changes in carotenoid pigment composition (xanthophyll cycle) and on specific members of the light-harvesting complex (LHC) family specialized in photoprotection (LHCX), which potentially act as NPQ effectors. However, the link between light stress, NPQ, and the existence of different LHCX isoforms is not understood in these organisms...
May 17, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29773197/efficient-zinc-uptake-is-critical-for-the-ability-of-pseudomonas-aeruginosa-to-express-virulence-traits-and-colonize-the-human-lung
#9
Maria Chiara Mastropasqua, Iain Lamont, Lois W Martin, David W Reid, Melania D'Orazio, Andrea Battistoni
We have recently shown that Pseudomonas aeruginosa, an opportunistic pathogen that chronically infects the lungs of patients with cystic fibrosis (CF) and other forms of lung disease, is extremely efficient in recruiting zinc from the environment and that this capability is required for its ability to cause acute lung infections in mice. To verify that P. aeruginosa faces zinc shortage when colonizing the lungs of human patients, we analyzed the expression of three genes that are highly induced under conditions of zinc deficiency (zrmA, dksA2 and rpmE2), in bacteria in the sputum of patients with inflammatory lung disease...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772875/measuring-high-density-built-environment-for-public-health-research-uncertainty-with-respect-to-data-indicator-design-and-spatial-scale
#10
Guibo Sun, Chris Webster, Michael Y Ni, Xiaohu Zhang
Uncertainty with respect to built environment (BE) data collection, measure conceptualization and spatial scales is evident in urban health research, but most findings are from relatively lowdensity contexts. We selected Hong Kong, an iconic high-density city, as the study area as limited research has been conducted on uncertainty in such areas. We used geocoded home addresses (n=5732) from a large population-based cohort in Hong Kong to extract BE measures for the participants' place of residence based on an internationally recognized BE framework...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29770988/probing-calcium-based-metal-organic-frameworks-via-natural-abundance-43ca-solid-state-nmr
#11
Shoushun Chen, Bryan Lucier, Mansheng Chen, Victor Terskikh, Yining Huang
Calcium-based MOFs are of high importance due to their low cost and bio-compatible metal centers. Understanding the local environment of calcium in these materials is critical for unraveling the origins of specific MOF properties. 43Ca solid-state NMR is one of the very few spectroscopic techniques that can directly characterize calcium metal centers, however, the 43Ca nucleus is a very challenging target for solid-state NMR due to its extremely low natural abundance and resonant frequency. In this work, natural abundance 43Ca solid-state NMR at a high magnetic field of 21...
May 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29766514/effect-of-catalytic-subunit-phosphorylation-on-the-properties-of-snrk1-from-phaseolus-vulgaris-embryos
#12
Esther Zúñiga-Sánchez, Rogelio Rodríguez-Sotres, Patricia Coello, Eleazar Martínez-Barajas
Legume seed development represents a high demand for energy and metabolic resources to support the massive synthesis of starch and proteins. However, embryo growth occurs in an environment with reduced O2 that forces the plant to adapt its metabolic activities to maximize efficient energy use. SNF1-related protein kinase1 (SnRK1) is a master metabolic regulator needed for cells adaptation to conditions that reduce energy availability, and its activity is needed for the successful development of seeds. In bean embryo extracts, SnRK1 can be separated by anion exchange chromatography into two pools: one where the catalytic subunit is phosphorylated (SnRK1-p) and another with reduced phosphorylation (SnRK1-np)...
May 16, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29766369/nutritional-issues-in-food-allergy
#13
REVIEW
Isabel J Skypala, Rebecca McKenzie
Diet and nutrition play an important role in the development and management of food allergy. The diet of expectant mothers can have an effect on their offspring in terms of allergic outcomes. A host of confounding factors may influence this, with a maternal diet rich in fruits and vegetables, fish, vitamin D-rich foods associated with a lower risk of allergic disease in their children. More surprisingly, the consumption of milk and butter has also been shown to have a protective effect, especially in a farm environment...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29764867/3d-fibrin-stiffness-mediates-dormancy-of-tumor-repopulating-cells-via-a-cdc42-driven-tet2-epigenetic-program
#14
Yuying Liu, Jiadi Lv, Xiaoyu Liang, Xiaonan Yin, Le Zhang, Degao Chen, Xun Jin, Roland Fiskesund, Ke Tang, Jingwei Ma, Huafeng Zhang, Wenqian Dong, Siqi Mo, Tianzhen Zhang, Feiran Cheng, Yabo Zhou, Jing Xie, Ning Wang, Bo Huang
Dormancy is recognized as a critical biological event for tumorigenic cells surviving in an extremely harsh environment. Understanding the molecular process of dormancy can unlock novel approaches to tackle cancers. We recently reported that stem-like tumor-repopulating cells (TRC) sense mechanical signals and rapidly proliferate in a 90 Pa soft fibrin matrix. Here we show that a stiff mechanical environment induces TRC dormancy via an epigenetic program initiated by translocation of Cdc42, a cytosolic regulator of mechanotransduction, into the nucleus, where it promotes transcription of hydroxymethylating enzyme Tet2...
May 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29761500/compositional-and-transcriptomic-analysis-associated-with-cuticle-lipid-production-on-rosette-and-inflorescence-stem-leaves-in-the-extremophyte-thellungiella-salsuginea
#15
Shuai Tang, Ningmei Chen, Buerbatu Song, Junqing He, Yijun Zhou, Matthew A Jenks, Xiaojing Xu
The plant cuticle is a complex structure composed primarily of wax and cutin, but also contains cutan, glycerolipids, phenolics, polysaccharides, and proteins. The cuticle plays an important protective role as barrier between plants and their environment. In this paper, 4-week old leaves produced either on the rosette or on the inflorescence stem of the model extremophyte Thellungiella salsuginea were examined using scanning electron microscopy, cuticle permeability assays, and chemical composition analysis...
May 14, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29760301/relationship-between-concealment-of-emotions-at-work-and-musculoskeletal-symptoms-results-from-the-third-korean-working-conditions-survey
#16
Kyungyong Jung, Dae Hwan Kim, Ji Young Ryu
In this study, we explored the relationship between concealing emotions at work and musculoskeletal symptoms in Korean workers using data from a national, population-based survey. Data were obtained from the third Korean Working Conditions Survey in 2011. We investigated the prevalence of three musculoskeletal symptoms ("back pain", "pain in the upper extremities", and "pain in the lower extremities"). Multiple logistic regression analysis was also performed to determine odds ratios (ORs) for musculoskeletal symptoms according to concealing emotions at work, adjusting for socioeconomic factors...
May 11, 2018: Industrial Health
https://www.readbyqxmd.com/read/29760111/a-simplified-method-to-estimate-the-run-off-in-periglacial-creeks-a-case-study-of-king-george-islands-antarctic-peninsula
#17
Ulrike Falk, Adrián Silva-Busso, Pablo Pölcher
Although the relationship between surface air temperature and glacial discharge has been studied in the Northern Hemisphere for at least a century, similar studies for Antarctica remain scarce and only for the past four decades. This data scarcity is due to the extreme meteorological conditions and terrain inaccessibility. As a result, the contribution of glacial discharge in Antarctica to global sea-level rise is still attached with great uncertainties, especially from partly glaciated hydrological basins as can be found in the Antarctic Peninsula...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760108/anatomy-of-a-glacial-meltwater-discharge-event-in-an-antarctic-cove
#18
Michael P Meredith, Ulrike Falk, Anna Valeria Bers, Andreas Mackensen, Irene R Schloss, Eduardo Ruiz Barlett, Kerstin Jerosch, Adrián Silva Busso, Doris Abele
Glacial meltwater discharge from Antarctica is a key influence on the marine environment, impacting ocean circulation, sea level and productivity of the pelagic and benthic ecosystems. The responses elicited depend strongly on the characteristics of the meltwater releases, including timing, spatial structure and geochemical composition. Here we use isotopic tracers to reveal the time-varying pattern of meltwater during a discharge event from the Fourcade Glacier into Potter Cove, northern Antarctic Peninsula...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760089/uncertainty-in-forecasts-of-long-run-economic-growth
#19
P Christensen, K Gillingham, W Nordhaus
Forecasts of long-run economic growth are critical inputs into policy decisions being made today on the economy and the environment. Despite its importance, there is a sparse literature on long-run forecasts of economic growth and the uncertainty in such forecasts. This study presents comprehensive probabilistic long-run projections of global and regional per-capita economic growth rates, comparing estimates from an expert survey and a low-frequency econometric approach. Our primary results suggest a median 2010-2100 global growth rate in per-capita gross domestic product of 2...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29760070/pacing-of-paleozoic-macroevolutionary-rates-by-milankovitch-grand-cycles
#20
James S Crampton, Stephen R Meyers, Roger A Cooper, Peter M Sadler, Michael Foote, David Harte
Periodic fluctuations in past biodiversity, speciation, and extinction have been proposed, with extremely long periods ranging from 26 to 62 million years, although forcing mechanisms remain speculative. In contrast, well-understood periodic Milankovitch climate forcing represents a viable driver for macroevolutionary fluctuations, although little evidence for such fluctuation exists except during the Late Cenozoic. The reality, magnitude, and drivers of periodic fluctuations in macroevolutionary rates are of interest given long-standing debate surrounding the relative roles of intrinsic biotic interactions vs...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
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