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osteoarthritis + herbal

Shobhit Srivastava, Anil K Saksena, Sanjay Khattri, Santosh Kumar, Raghubendra Singh Dagur
BACKGROUND AND PURPOSE: Curcuma longa L. (CL), an Indian herb, has been used to treat many disorders because of its wide spectrum of pharmacological activities. It has been shown to exhibit anti-oxidant and anti-inflammatory properties, and is being used as herbal remedy since ancient times. Osteoarthritis of knee (KOA) is a chronic painful disorder in which prolong use of non-steroidal anti-inflammatory drugs (NSAIDs) or steroids may result into many serious side effects; hence, there is a need to develop herbal drugs, having good analgesia without side effects...
October 19, 2016: Inflammopharmacology
Jae-Seek You, In-A Cho, Kyeong-Rok Kang, Ji-Su Oh, Sang-Joun Yu, Gyeong-Je Lee, Yo-Seob Seo, Su-Gwan Kim, Chun Sung Kim, Do Kyung Kim, Hee-Jeong Im, Jae-Sung Kim
In the present study, we investigated the anti-catabolic effects of coumestrol, a phytoestrogen derived from herbal plants, against interleukin-1β-induced cartilage degeneration in primary rat chondrocytes and articular cartilage. Coumestrol did not affect the viability of human normal oral keratinocytes and primary rat chondrocytes treated for 24 h and 21 days, respectively. Although coumestrol did not significantly increase the proteoglycan contents in long-term culture, it abolished the interleukin-1β-induced loss of proteoglycans in primary rat chondrocytes and knee articular cartilage...
October 5, 2016: Inflammation
Jin Kyun Park, Kichul Shin, Eun-Ha Kang, You-Jung Ha, Yun Jong Lee, Kyung Hee Lee, Eun Young Lee, Yeong Wook Song, Yunhee Choi, Eun Bong Lee
PURPOSE: The aim of this study was to investigate the efficacy and tolerability of GCSB-5, a mixture of 6 purified herbal extracts, in treating hand osteoarthritis (OA). METHODS: A randomized, double-blind, placebo-controlled trial enrolled 220 patients with hand OA who had baseline a visual analog scale joint pain score of >30 of 100 mm at 3 hospitals between September 2013 and November 2014. After randomization, patients were allocated to receive oral GCSB-5 600 mg or placebo, bid for 12 weeks...
August 2016: Clinical Therapeutics
Mariana Del Grossi Moura, Luciane Cruz Lopes, Maique Weber Biavatti, Jason W Busse, Li Wang, Sean Alexander Kennedy, Neera Bhatnaga, Cristiane de Cássia Bergamaschi
BACKGROUND: Osteoarthritis affects 1 % of the world's population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are commonly used in Brazil to manage symptoms associated with osteoarthritis, and some of them are financed by the Brazilian government; however, the effectiveness of most of these agents is uncertain. The aim was to systematically review the efficacy and safety of 13 oral herbal medications used in Brazil for the treatment of osteoarthritis...
2016: Systematic Reviews
Atousa Ziaei, Shamim Sahranavard, Mohammad Javad Gharagozlou, Mehrdad Faizi
BACKGROUND: Many plants have been introduced in Iranian traditional medicine for treatment of different joint problems including knee pain. Topical application of the mixture of Lawsonia inermis L. leaves (Henna) with aqueous extract of Ricinus communis L. leaves have been mentioned to have significant effects on reducing knee pain. The present study was designed to evaluate the analgesic and anti-inflammatory effects of the mixture of these two herbs in male rats. METHODS: We induced knee osteoarthritis as a model of chronic pain by intra-articular injection of mono sodium iodoacetate (MIA)...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Huaqi Tang, Shuaibing He, Xinyue Zhang, Shilin Luo, Baixia Zhang, Xiaojie Duan, Zhiqian Zhang, Wenqi Wang, Yun Wang, Yikun Sun
As the most familiar type of arthritis and a chronic illness of the joints, Osteoarthritis (OA) affects a great number of people on the global scale. XuanHuSuo powder (XHSP), a conventional herbal formula from China, has been extensively applied in OA treatment. Nonetheless, its pharmacological mechanism has not been completely expounded. In this research, a network pharmacology approach has been chosen to study the pharmacological mechanism of XHSP on OA, and the pharmacology networks were established based on the relationship between four herbs found in XHSP, compound targets, and OA targets...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Won Kyung Kim, Hwa-Jin Chung, Yuna Pyee, Tae Jun Choi, Hyen Joo Park, Ji-Young Hong, Joon-Shik Shin, Jin Ho Lee, In-Hyuk Ha, Sang Kook Lee
BACKGROUND: SHINBARO is a refined herbal formulation used to treat inflamed lesions and bone diseases. This study aimed to investigate the anti-osteoarthritic activities of intra-articular administration of SHINBARO and determine its underlying molecular mechanism in a monosodium iodoacetate (MIA)-induced osteoarthritis rat model. METHODS: Male Sprague-Dawley rats received a single intra-articular injection of MIA into the infrapatellar ligament of the right knee...
2016: Chinese Medicine
Chul-Won Ha, Yong-Beom Park, Byung-Woo Min, Seung-Beom Han, Jae Hyup Lee, Ye-Yeon Won, Ye-Soo Park
ETHNOPHARMACOLOGICAL RELEVANCE: This prospective, randomized, double-blinded, double-dummy, multicenter study compared the efficacy and safety of PG201 (Layla®), a new product from extracts of 12 plant sources and SKI306X (Joins®) which have been well investigated and in relatively wide usage among herbal medicine, for the treatment of patients with knee osteoarthritis. AIM OF THE STUDY: To compare the efficacy and safety of PG201 and SKI306X in patients with knee osteoarthritis...
April 2, 2016: Journal of Ethnopharmacology
Maryam Mashmoul, Azrina Azlan, Huzwah Khaza'ai, Barakatun Nisak Mohd Yusof, Sabariah Mohd Noor
Obesity is associated with various diseases, particularly diabetes, hypertension, osteoarthritis and heart disease. Research on possibilities of herbal extracts and isolated compounds from natural products for treating obesity has an upward trend. Saffron (Crocus Sativus L. Iridaceae) is a source of plant polyphenols/carotenoids, used as important spice and food colorant in different parts of the world. It has also been used in traditional medicine for treatment of different types of illnesses since ancient times...
2013: Antioxidants (Basel, Switzerland)
Yudi Zhang, Rongheng Li, Yu Zhong, Sihan Zhang, Lingyun Zhou, Shike Shang
Fuyuan Decoction (FYD), a herbal formula in China, has been widely used for osteoarthritis (OA) treatment. Herein, we determined the effects of FYD on the expression of transcription factor SOX9 and its target gene collagen type II, alpha 1 (COL2A1) as well as the activation of Smad2/3 in interleukin- (IL-) 1β-stimulated SW1353 chondrosarcoma cells. Serum-derived FYD (FYD-CS) was prepared to treat SW1353 cells with or without SB431542, a TGF-β1 receptor inhibitor. Cell cycle progression was tested by flow cytometry...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
M-A Fitzcharles, C Baerwald, J Ablin, W Häuser
BACKGROUND: In the absence of an ideal treatment for chronic pain associated with rheumatic diseases, there is interest in the potential effects of cannabinoid molecules, particularly in the context of global interest in the legalization of herbal cannabis for medicinal use. METHODS: A systematic search until April 2015 was conducted in Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and for randomized controlled trials with a study duration of at least 2 weeks and at least ten patients per treatment arm with herbal cannabis or pharmaceutical cannabinoid products in fibromyalgia syndrome (FMS), osteoarthritis (OA), chronic spinal pain, and rheumatoid arthritis (RA) pain...
February 2016: Der Schmerz
Wenming Zhang, Shangquan Wang, Ranxing Zhang, Yuanyuan Zhang, Xinjian Li, Yanping Lin, Xu Wei
OBJECTIVES: Duhuo Jisheng decoction (DJD) is considered beneficial for controlling knee osteoarthritis (KOA)-related symptoms in some Asian countries. This review compiles the evidence from randomised clinical trials and quantifies the effects of DJD on KOA. DESIGNS: 7 online databases were investigated up to 12 October 2015. Randomised clinical trials investigating treatment of KOA for which DJD was used either as a monotherapy or in combination with conventional therapy compared to no intervention, placebo or conventional therapy, were included...
2016: BMJ Open
Xue-Wei Cao, Da Guo, Jin-Wen Liu, Wei Niu, Jun Liu, Jian-Ke Pan, Hui Xie, Wen-Wei Ouyang, Ding-Kun Lin
BACKGROUND: Knee osteoarthritis (KOA) is a major public health issue causing chronic disability as well as a burden on healthcare resources. In China, a herbal drug tablet has been used as an effective and conventional therapy to alleviate clinical symptoms caused by KOA. However, evidence gathered from systematic reviews or randomized controlled trials that validated herbal drugs for the management of osteoarthritic pain is weak. The purpose of this study is to explore the efficacy and safety of the Shaoyao Shujin tablet for the management of KOA in a short-term study...
2016: Trials
Wei-heng Chen, Xian-xiang Liu, Pei-jian Tong, Hong-sheng Zhan
Literature review shows that Chinese medicine and other related treatment are still the main stream treatment of knee osteoarthritis. Currently, there is short of handbook guiding Chinese medicine from evidence-based medical evidence, so it is a top priority to develop a clinical guideline from the expert consensus. After several rounds of discussion during the conference and examination by letter, which has collected opinions from nearly one hundred experts, consensus was reached. Nonpharmacologic interventions include health education, medical exercise, acupuncture, massage, acupotomology, and physiotherapy...
February 2016: Chinese Journal of Integrative Medicine
Liguo Zhu, Shaofeng Yang, Shangquan Wang, Hao Gong, Linghui Li, Xu Wei
Objective. To assess the current clinical evidence of manufactured Chinese herbal formulae (MCHF) for knee osteoarthritis (KOA). Methods. Seven databases were searched from inception to May 2015. Eligible randomized controlled trials investigating the effectiveness of MCHF for KOA were included. Data extraction, methodological assessment, and meta-analyses were conducted according to the Cochrane standards. Results. A total of 17 kinds of MCHF were identified from the twenty-six included trials. Meta-analyses showed that MCHF significantly relieved the global pain of knee joints, either used alone or combined with routine treatments...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Bin Zhang, Gang Chen, Hai-long Li, Hai-peng Ren, Tao Yang, Min Chen, Li-gang Guo
Xiatianwu tablet is based on the theory of traditional Chinese medicine (TCM), combined with modern TCM pharmacology and selected 33 famous traditional Chinese crude drugs to compose. Its recipe helps cure rheumatism, relax tendons, promote blood circulation to relieve pain, et al. Although Xiatianwu tablets are widely applied to clinical remedy such as rheumatic arthritis, lumbar disc hernia, osteoarthritis and so on, there is no report about its application in fracture. This article is to observe the efficacy of compound Xiatianwu tablets in elderly patients with osteoporotic distal radius fractures and its impact on the wrist function and complications...
June 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Pu-Wei Hou, Pin-Kuei Fu, Hsin-Cheng Hsu, Ching-Liang Hsieh
To evaluate whether the use of traditional Chinese medicine (TCM; zhōng yī) influences symptoms or functional outcomes in patients with osteoarthritis (OA) of the knee ( xī guān jié yán). A systematic review of randomized control trials was conducted. Searches for studies in PubMed that were performed between 1965 and August 2013, and retrieved studies were subjected to reference screening. The types of studies included in our review were 1) placebo-based or comparative studies; 2) open label, single-blinded or double-blinded studies; 3) studies evaluating the efficacy of TCM for treating OA of the knee; and 4) studies evaluating only TCM or combination preparations...
October 2015: Journal of Traditional and Complementary Medicine
Mary-Ann Fitzcharles, Peter A Ste-Marie, Winfried Häuser, Daniel J Clauw, Shahin Jamal, Jacob Karsh, Tara Landry, Sharon Leclercq, Jason J Mcdougall, Yoram Shir, Kam Shojania, Zach Walsh
OBJECTIVE: To assess the efficacy, tolerability, and safety of cannabinoids (phyto- and syntheto-) in the management of rheumatic diseases. METHODS: Multiple databases, including Medline, Embase, and CENTRAL, were searched. Randomized controlled trials with outcomes of pain, sleep, quality of life, tolerability (dropouts due to adverse events), and safety (serious adverse events), with comparison of cannabinoids with any type of control, were included. Study methodology quality was evaluated with the Cochrane risk of bias tool...
May 2016: Arthritis Care & Research
Bo Chen, Hongsheng Zhan, Mei Chung, Xun Lin, Min Zhang, Jian Pang, Chenchen Wang
Objective. Chinese herbal bath therapy (CHBT) has traditionally been considered to have analgesic and anti-inflammatory effects. We conducted the first meta-analysis evaluating its benefits for patients with knee osteoarthritis (OA). Methods. We searched three English and four Chinese databases through October, 2014. Randomized trials evaluating at least 2 weeks of CHBT for knee OA were selected. The effects of CHBT on clinical symptoms included both pain level (via the visual analog scale) and total effectiveness rate, which assessed pain, physical performance, and wellness...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Qian-Qian Liang, Qi Shi, Ronald W Wood, Lian-Ping Xing, Yong-Jun Wang
Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most common joint diseases, and they have characterization of synovial inflammation and cartilage destruction, associated with the accumulation of numerous catabolic mediators and inflammatory cells in the synovial space and surrounding soft tissues. How these factors are cleared and if the "clearance" process contributes to pathogenesis of arthritis are not known. Recently, we found the existence of the peri-articular lymphatic system in mouse joints...
September 2015: Chinese Journal of Integrative Medicine
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