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JOURNAL ARTICLE
Mario M Leitao, Alexia Iasonos, Morgan Tomberlin, Lea A Moukarzel, Hannah Price, Gabrielle Bennetti, Bhavani Ramesh, Dennis S Chi, Kara Long Roche, Yukio Sonoda, Ahmed Al-Niami, Jennifer J Mueller, Ginger J Gardner, Vance Broach, Elizabeth L Jewell, Sarah Kim, Jacqueline Feinberg, Nadeem R Abu-Rustum, Oliver Zivanovic
BACKGROUND: Ovarian cancer with extensive metastatic disease involving pelvic structures often requires rectosigmoid resection for complete gross resection; however, it is associated with increased surgical morbidity. There are limited data, and none in ovarian cancer, on near-infrared assessment of perfusion in rectosigmoid resections with anastomosis. PRIMARY OBJECTIVE: To compare the rate of pelvic complications (pelvic abscesses, anastomotic leaks, and infections) within 30 days of surgery with and without near-infrared assessment of perfusion at time of rectosigmoid resection and re-anastomosis in patients undergoing cytoreductive surgery for ovarian cancer...
March 21, 2024: International Journal of Gynecological Cancer
#2
JOURNAL ARTICLE
Aaron M Praiss, Rahim Hirani, Qin Zhou, Alexia Iasonos, Yukio Sonoda, Nadeem R Abu-Rustum, Mario M Leitao, Kara Long Roche, Vance Broach, Ginger J Gardner, Dennis S Chi, Oliver Zivanovic
OBJECTIVE: To assess the impact of short-term postoperative complications on oncologic outcomes for patients with epithelial ovarian cancer undergoing primary cytoreductive surgery (PCS) or interval cytoreductive surgery (ICS) with intestinal resection. METHODS: A retrospective chart review was performed for patients with ovarian cancer who underwent PCS or ICS with at least one intestinal resection at our institution from 1/1/2015 to 12/31/2020. Progression-free survival (PFS) and overall survival (OS) were analyzed for the PCS and ICS cohorts separately...
December 2023: Gynecologic Oncology
#3
JOURNAL ARTICLE
Sungmin Woo, Pamela Causa Andrieu, Nadeem R Abu-Rustum, Vance Broach, Oliver Zivanovic, Yukio Sonoda, Dennis S Chi, Emeline Aviki, Annie Ellis, Pascale Carayon, Hedvig Hricak, Hebert A Vargas
RATIONALE AND OBJECTIVES: This study aimed to evaluate whether implementing structured reporting based on Ovarian-Adnexal Reporting and Data System (O-RADS) magnetic resonance imaging (MRI) in women with sonographically indeterminate adnexal masses improves communication between radiologists, referrers, and patients/caregivers and enhances diagnostic performance for determining adnexal malignancy. MATERIALS AND METHODS: We retrospectively analyzed prospectively issued MRI reports in 2019-2022 performed for characterizing adnexal masses before and after implementing O-RADS MRI; 56 patients/caregivers and nine gynecologic oncologists ("referrers") were surveyed about report interpretability/clarity/satisfaction; responses for pre- and post-implementation reports were compared using Fisher's exact and Chi-squared tests...
September 1, 2023: Academic Radiology
#4
Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L Hamilton-Nelson, Nicholas R Wheeler, Yi Zhao, John J Farrell, Michelle A Grunin, Yuk Yee Leung, Pavel P Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse B Mez, Ellen L Palmer, Jagan Pillai, Richard M Sherva, Yeunjoo E Song, Xiaoling Zhang, Taha Iqbal, Omkar Pathak, Otto Valladares, Amanda B Kuzma, Erin Abner, Perrie M Adams, Alyssa Aguirre, Marilyn S Albert, Roger L Albin, Mariet Allen, Lisa Alvarez, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Gayle Ayres, Clinton T Baldwin, Robert C Barber, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Gary W Beecham, Duane Beekly, Bruno A Benitez, David Bennett, John Bertelson, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James Brewer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Laura B Cantwell, Chuanhai Cao, Christopher S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A Chin, Helena C Chui, Jaeyoon Chung, Suzanne Craft, Paul K Crane, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Michael L Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W Dickson, Beth A Dombroski, Rachelle S Doody, Ranjan Duara, NIlüfer Ertekin-Taner, Denis A Evans, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, David W Fardo, Martin R Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Tatiana M Foroud, Matthew P Frosch, Brian Fulton-Howard, Douglas R Galasko, Adriana Gamboa, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Alison M Goate, Thomas J Grabowski, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, James Hall, Ronald L Hamilton, Oscar Harari, John Hardy, Lindy E Harrell, Elizabeth Head, Victor W Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Linda S Hynan, Laura Ibanez, Gail P Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M Ilyas Kamboh, Anna M Karydas, Mindy J Katz, John S Kauwe, Jeffrey A Kaye, C Dirk Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W Kowall, Joel H Kramer, Walter A Kukull, Frank M LaFerla, James J Lah, Eric B Larson, Alan Lerner, James B Leverenz, Allan I Levey, Andrew P Lieberman, Richard B Lipton, Mark Logue, Oscar L Lopez, Kathryn L Lunetta, Constantine G Lyketsos, Douglas Mains, Flanagan E Margaret, Daniel C Marson, Eden R R Martin, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Stefan McDonough, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Thomas J Montine, Edwin S Monuki, John C Morris, Shubhabrata Mukherjee, Amanda J Myers, Trung Nguyen, Sid O'Bryant, John M Olichney, Marcia Ory, Raymond Palmer, Joseph E Parisi, Henry L Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Marsha Polk, Wayne W Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F Quinn, Ashok Raj, Murray Raskind, Eric M Reiman, Barry Reisberg, Joan S Reisch, John M Ringman, Erik D Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Donald R Royall, Mark A Sager, Mary Sano, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Susan H Slifer, Scott Small, Amanda G Smith, Janet P Smith, Joshua A Sonnen, Salvatore Spina, Peter St George-Hyslop, Robert A Stern, Alan B Stevens, Stephen M Strittmatter, David Sultzer, Russell H Swerdlow, Rudolph E Tanzi, Jeffrey L Tilson, John Q Trojanowski, Juan C Troncoso, Debby W Tsuang, Vivianna M Van Deerlin, Linda J van Eldik, Jeffery M Vance, Badri N Vardarajan, Robert Vassar, Harry V Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Patrice L Whitehead, Ellen M Wijsman, Kirk C Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S Wingo, Thomas Wisniewski, Randall L Woltjer, Martin Woon, Clinton B Wright, Chuang-Kuo Wu, Steven G Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W Kunkle, William S Bush, Li-San Wang, Lindsay A Farrer, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Gyungah R Jun, Christiane Reitz, Adam C Naj
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer's Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis...
July 8, 2023: medRxiv
#5
JOURNAL ARTICLE
Tiffany Y Sia, Beryl L Manning-Geist, Sarah Ehmann, Jessica A Lavery, Carrie Luardo, Aaron Praiss, Alexia Iasonos, Yukio Sonoda, Rachel N Grisham, Ying L Liu, Vance Broach, Oliver Zivanovic, Kara Long Roche, Ginger J Gardner, Dennis S Chi
OBJECTIVES: To compare outcomes of patients with high-grade epithelial ovarian cancer (EOC) who underwent secondary cytoreduction surgery (SCS) after up-front treatment with neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS) versus primary debulking surgery (PDS). METHODS: Patients with high-grade EOC who underwent SCS from 2/1/2004-10/31/2021 were classified by up-front treatment. Clinical and treatment characteristics were compared between cohorts...
July 14, 2023: Gynecologic Oncology
#6
JOURNAL ARTICLE
Jacqueline Feinberg, Oliver Zivanovic, Michael Hannon, Taylor McCready, Priyanka Desai, Sarah H Kim, Emeline M Aviki, Jennifer J Mueller, Elizabeth L Jewell, Kara Long Roche, Ginger J Gardner, Dennis S Chi, Yukio Sonoda, Carol L Brown, Nadeem R Abu-Rustum, Jennifer R Cracchiolo, Mario M Leitao, Vance Broach
OBJECTIVE: To describe patient-reported postoperative symptoms and to evaluate the use of digital symptom tracking and alerts to detect postoperative complications. METHODS: We retrospectively reviewed patients who underwent a minimally invasive hysterectomy and enrolled in our Recovery Tracker program from 4/5/17-12/31/21. The Recovery Tracker is an at-home virtual tool used to track patient-reported postoperative symptoms for 10 days. Predefined thresholds for "red" and "yellow" alerts are based on symptom severity and timing...
June 27, 2023: Gynecologic Oncology
#7
JOURNAL ARTICLE
Ignacio Vázquez-García, Florian Uhlitz, Nicholas Ceglia, Jamie L P Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B Ruiz, Kevin M Boehm, Viktoria Bojilova, Christopher J Fong, Tyler Funnell, Diljot Grewal, Eliyahu Havasov, Samantha Leung, Arfath Pasha, Druv M Patel, Maryam Pourmaleki, Nicole Rusk, Hongyu Shi, Rami Vanguri, Marc J Williams, Allen W Zhang, Vance Broach, Dennis S Chi, Arnaud Da Cruz Paula, Ginger J Gardner, Sarah H Kim, Matthew Lennon, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Ritika Kundra, Agnes Viale, Fatemeh N Derakhshan, Luke Geneslaw, Shirin Issa Bhaloo, Ana Maroldi, Rahelly Nunez, Fresia Pareja, Anthe Stylianou, Mahsa Vahdatinia, Yonina Bykov, Rachel N Grisham, Ying L Liu, Yulia Lakhman, Ines Nikolovski, Daniel Kelly, Jianjiong Gao, Andrea Schietinger, Travis J Hollmann, Samuel F Bakhoum, Robert A Soslow, Lora H Ellenson, Nadeem R Abu-Rustum, Carol Aghajanian, Claire F Friedman, Andrew McPherson, Britta Weigelt, Dmitriy Zamarin, Sohrab P Shah
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability1-4 patterned by distinct mutational processes5,6 , tumour heterogeneity7-9 and intraperitoneal spread7,8,10 . Immunotherapies have had limited efficacy in HGSOC11-13 , highlighting an unmet need to assess how mutational processes and the anatomical sites of tumour foci determine the immunological states of the tumour microenvironment. Here we carried out an integrative analysis of whole-genome sequencing, single-cell RNA sequencing, digital histopathology and multiplexed immunofluorescence of 160 tumour sites from 42 treatment-naive patients with HGSOC...
December 2022: Nature
#8
RANDOMIZED CONTROLLED TRIAL
Lea A Moukarzel, Nguyen Nguyen, Qin Zhou, Alexia Iasonos, Maria B Schiavone, Bhavani Ramesh, Dennis S Chi, Yukio Sonoda, Nadeem R Abu-Rustum, Jennifer J Mueller, Kara Long Roche, Elizabeth L Jewell, Vance Broach, Oliver Zivanovic, Mario M Leitao
OBJECTIVE: To determine the relationship between bowel preparation and surgical-site infection (SSI) incidence following colorectal resection during gynecologic oncology surgery. METHODS: This post-hoc analysis used data from a randomized controlled trial of patients enrolled from 03/01/2016-08/20/2019 with presumed gynecologic malignancy investigating negative-pressure wound therapy among those requiring laparotomy. Patients were treated preoperatively without bowel preparation, oral antibiotic bowel preparation (OABP), or OABP plus mechanical bowel preparation (MBP) per surgeon preference...
January 2023: Gynecologic Oncology
#9
JOURNAL ARTICLE
Alex Riolexus Ario, Issa Makumbi, Daniel Kadobera, Lilian Bulage, Felix Ocom, Benon Kwesiga, Dennis F Jarvis, Sandra Nabatanzi, Jaco Homsy, Flora Banage, Vance Brown, Julie R Harris, Amy L Boore, Lisa J Nelson, Sue Binder, Henry G Mwebesa, Jane R Aceng
Uganda is an ecological hot spot with porous borders that lies in several infectious disease transmission belts, making it prone to disease outbreaks. To prepare and respond to these public health threats and emergencies in a coordinated manner, Uganda established the Uganda National Institute of Public Health (UNIPH) in 2013.Using a step-by-step process, Uganda's Ministry of Health (MOH) crafted a strategy with a vision, mission, goal, and strategic objectives, and identified value additions and key enablers for success...
August 30, 2022: Global Health, Science and Practice
#10
JOURNAL ARTICLE
Kay J Park, Vance Broach, Dennis S Chi, Irina Linkov, Frank Z Stanczyk, Prusha Patel, Anjali Jotwani, Celeste Leigh Pearce, Malcolm C Pike, Noah D Kauff
BACKGROUND: The objectives of this study were (i) to explore if differences in cell proliferation may help explain why most high-grade serous ovarian cancers (HGSOCs) arise in the fallopian tube fimbriae (FTF) rather than in ovarian cortical inclusion cysts (CICs); (ii) to compare premenopausal and postmenopausal FTF proliferation as a reason why the age-incidence of HGSOC increases at a slower rate after menopause; and (iii) to compare FTF proliferation in cycling women and women using the levonorgestrel intra-uterine contraceptive system (Lng-IUS) to see whether proliferation on the Lng-IUS was lower...
June 14, 2022: Cancer Epidemiology, Biomarkers & Prevention
#11
JOURNAL ARTICLE
Dennis Kannenkeril, Janis M Nolde, Márcio Galindo Kiuchi, Revathy Carnagarin, Leslie Marisol Lugo-Gavidia, Justine Chan, Anu Joyson, Ancy Jose, Sandi Robinson, Vance B Matthews, Lakshini Y Herat, Omar Azzam, Shaun Frost, Markus P Schlaich
OBJECTIVE: We analyzed whether any change in capillary density in the retinal circulation could be detected in patients with hypertension in the prediabetic stage. RESEARCH DESIGN AND METHODS: In a cross-sectional analysis, we assessed capillary density in the foveal (CDF) and parafoveal retinal areas using optical coherence tomography-angiography in 62 patients with hypertension and normal glucose metabolism and 40 patients with hypertension and prediabetes. RESULTS: The CDF was lower in patients with prediabetes than in those with normal glucose metabolism...
June 2, 2022: Diabetes Care
#12
JOURNAL ARTICLE
Siyu Wang, Stephanie M Reeve, Graham T Holt, Adegoke A Ojewole, Marcel S Frenkel, Pablo Gainza, Santosh Keshipeddy, Vance G Fowler, Dennis L Wright, Bruce R Donald
Antimicrobial resistance presents a significant health care crisis. The mutation F98Y in Staphylococcus aureus dihydrofolate reductase (SaDHFR) confers resistance to the clinically important antifolate trimethoprim (TMP). Propargyl-linked antifolates (PLAs), next generation DHFR inhibitors, are much more resilient than TMP against this F98Y variant, yet this F98Y substitution still reduces efficacy of these agents. Surprisingly, differences in the enantiomeric configuration at the stereogenic center of PLAs influence the isomeric state of the NADPH cofactor...
February 2022: PLoS Computational Biology
#13
JOURNAL ARTICLE
Emeline M Aviki, Beryl L Manning-Geist, Stefania S Sokolowski, Tiffanny Newman, Victoria S Blinder, Fumiko Chino, Stephanie M Doyle, Allison Liebhaber, Sushmita B Gordhandas, Carol L Brown, Vance Broach, Dennis S Chi, Elizabeth L Jewell, Mario M Leitao, Kara Long Roche, Jennifer J Mueller, Yukio Sonoda, Oliver Zivanovic, Ginger J Gardner, Nadeem R Abu-Rustum
BACKGROUND: The cost of cancer care is high and rising. Evidence of increased patient cost burden is prevalent in the medical literature and has been defined as "financial toxicity," the financial hardship and financial concerns experienced by patients because of a disease and its related treatments. With targeted therapies and growing out-of-pocket costs, patient financial toxicity is a growing concern among patients with gynecologic cancer. OBJECTIVE: This study aimed to determine the prevalence of financial toxicity and identify its risk factors in patients with gynecologic cancer treated at a large cancer center using objective data...
June 2022: American Journal of Obstetrics and Gynecology
#14
JOURNAL ARTICLE
Anita Ayer, Daniel J Fazakerley, Cacang Suarna, Ghassan J Maghzal, Diba Sheipouri, Kevin J Lee, Michelle C Bradley, Lucía Fernández-Del-Rio, Sergey Tumanov, Stephanie My Kong, Jelske N van der Veen, Andrian Yang, Joshua W K Ho, Steven G Clarke, David E James, Ian W Dawes, Dennis E Vance, Catherine F Clarke, René L Jacobs, Roland Stocker
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of pathologies. What drives CoQ deficiency in many of these pathologies is unknown, just as there currently is no effective therapeutic strategy to overcome CoQ deficiency in humans. To date, large-scale studies aimed at systematically interrogating endogenous systems that control CoQ biosynthesis and their potential utility to treat disease have not been carried out...
October 2021: Redox Biology
#15
REVIEW
Leslie Marisol Lugo-Gavidia, Dylan Burger, Vance B Matthews, Janis M Nolde, Márcio Galindo Kiuchi, Revathy Carnagarin, Dennis Kannenkeril, Justine Chan, Anu Joyson, Lakshini Y Herat, Omar Azzam, Markus P Schlaich
[Figure: see text].
June 2021: Hypertension
#16
JOURNAL ARTICLE
Yoelvis Garcia-Mesa, He N Xu, Patricia Vance, Analise L Gruenewald, Rolando Garza, Cecily Midkiff, Xavier Alvarez-Hernandez, David J Irwin, Alexander J Gill, Dennis L Kolson
Dimethyl fumarate (DMF), an antioxidant/anti-inflammatory drug approved for the treatment of multiple sclerosis, induces antioxidant enzymes, in part through transcriptional upregulation. We hypothesized that DMF administration to simian immunodeficiency virus (SIV)-infected rhesus macaques would induce antioxidant enzyme expression and reduce oxidative injury and inflammation throughout the brain. Nine SIV-infected, CD8+ -T-lymphocyte-depleted rhesus macaques were studied. Five received oral DMF prior to the SIV infection and through to the necropsy day...
March 9, 2021: Antioxidants (Basel, Switzerland)
#17
COMPARATIVE STUDY
Yu-Ling Chang, Maura Rossetti, David W Gjertson, Liudmilla Rubbi, Michael Thompson, Dennis J Montoya, Marco Morselli, Felicia Ruffin, Alexander Hoffmann, Matteo Pellegrini, Vance G Fowler, Michael R Yeaman, Elaine F Reed
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is life threatening and occurs in up to 30% of MRSA bacteremia cases despite appropriate antimicrobial therapy. Isolates of MRSA that cause antibiotic-persistent methicillin-resistant S. aureus bacteremia (APMB) typically have in vitro antibiotic susceptibilities equivalent to those causing antibiotic-resolving methicillin-resistant S. aureus bacteremia (ARMB). Thus, persistence reflects host-pathogen interactions occurring uniquely in context of antibiotic therapy in vivo...
March 9, 2021: Proceedings of the National Academy of Sciences of the United States of America
#18
JOURNAL ARTICLE
Richard R Sprenger, Martin Hermansson, Ditte Neess, Lena Sokol Becciolini, Signe Bek Sørensen, Rolf Fagerberg, Josef Ecker, Gerhard Liebisch, Ole N Jensen, Dennis E Vance, Nils J Færgeman, Robin W Klemm, Christer S Ejsing
Diurnal regulation of whole-body lipid metabolism plays a vital role in metabolic health. Although changes in lipid levels across the diurnal cycle have been investigated, the system-wide molecular responses to both short-acting fasting-feeding transitions and longer-timescale circadian rhythms have not been explored in parallel. Here, we perform time-series multi-omics analyses of liver and plasma revealing that the majority of molecular oscillations are entrained by adaptations to fasting, food intake, and the postprandial state...
February 2, 2021: Cell Reports
#19
JOURNAL ARTICLE
Janis M Nolde, Leslie Marisol Lugo-Gavidia, Dennis Kannenkeril, Justine Chan, Vance B Matthews, Revathy Carnagarin, Omar Azzam, Márcio Galindo Kiuchi, Markus P Schlaich
BACKGROUND: Positional changes in blood pressure (BP) have been shown to have effects on long-term outcomes. Although a BP drop with upright posture is frequently observed, an orthostatic rise in BP can also occur. Here, we aimed to investigate whether the phenotype of orthostatic hypertension is associated with more pronounced vascular hypertension-mediated organ damage (HMOD) and whether this is associated with other cardiovascular risk factors. METHODS: In a cohort of 200 patients referred to our tertiary hypertension clinic, we prospectively assessed unattended seated automated office BP and the response to 1 min of upright posture...
July 1, 2021: Journal of Hypertension
#20
RANDOMIZED CONTROLLED TRIAL
Mario M Leitao, Qin C Zhou, Maria B Schiavone, Renee A Cowan, Evan S Smith, Alexia Iasonos, Mitchell Veith, Michael Rafizadeh, Katherine Curran, Bhavani Ramesh, Kaity Chang, Dennis S Chi, Yukio Sonoda, Amy K Brown, Jonathan A Cosin, Nadeem R Abu-Rustum, Martin A Martino, Jennifer J Mueller, Kara Long Roche, Elizabeth L Jewell, Vance Broach, Nicholas C Lambrou, John P Diaz, Oliver Zivanovic
OBJECTIVE: To estimate the effectiveness of prophylactic negative pressure wound therapy in patients undergoing laparotomy for gynecologic surgery. METHODS: We conducted a randomized controlled trial. Eligible, consenting patients, regardless of body mass index (BMI), who were undergoing laparotomy for presumed gynecologic malignancy were randomly allocated to standard gauze or negative pressure wound therapy. Patients with BMIs of 40 or greater and benign disease also were eligible...
February 1, 2021: Obstetrics and Gynecology
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