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ARFI liver transplantation

Ying Tang, Jingwen Zhao, Huimin Yu, Hongtao Wu, Ningning Niu
OBJECTIVES: The aim of our study was to evaluate the clinical application of color Doppler flow imaging (CDFI) and acoustic radiation force impulse (ARFI) for the diagnosis of acute rejection after liver transplantation. METHODS: B-Mode CDFI and ARFI assessments were performed in 76 patients who underwent biopsy after liver transplantation at our institution, between October 2011 and October 2014. The study group included 56 patients with acute rejection confirmed by biopsy, with 20 patients whose liver function recovered within 1 month of transplantation forming the control group...
June 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
M Alfageme Zubillaga, T Fontanilla Echeveste, I Pérez González, A Royuela Vicente, A M Duca, R M Ruiz Peralbo, C González Hernando
OBJECTIVE: To evaluate the changes in the values obtained in acoustic radiation force impulse (ARFI) elastography of the liver after antiviral treatment in patients with liver transplants and hepatitis C virus (HVC) infection recurring after transplantation. MATERIAL AND METHODS: We studied 15 patients infected with HVC who had received liver transplants where an HVC infection recurring in the graft within one year after the transplant was treated with direct-acting antivirals...
March 2017: Radiología
Joel Schmillevitch, Maria Cristina Chammas, Vincenzo Pugliese, Edson Abdala, Adriana Cortez Rizzon, Venâncio Alves, Luiz Augusto Carneiro, Giovanni Cerri
CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
Yoshitaka Takuma, Youichi Morimoto, Hiroyuki Takabatake, Nobuyuki Toshikuni, Junko Tomokuni, Akiko Sahara, Kazuhiro Matsueda, Hiroshi Yamamoto
BACKGROUND & AIMS: Hepatic venous pressure gradient can predict mortality and hepatic decompensation in patients with cirrhosis. Measurement of hepatic venous pressure gradient requires an invasive procedure; therefore, prognostic markers are needed that do not require invasive procedures. We investigated whether measurements of spleen stiffness, made by acoustic radiation force impulse (ARFI) imaging, associated with mortality and decompensation in patients with cirrhosis, compared with liver stiffness and other markers...
November 2017: Clinical Gastroenterology and Hepatology
Sylviane Hanquinet, Delphine S Courvoisier, Anne-Laure Rougemont, Barbara E Wildhaber, Laura Merlini, Valérie A McLin, Mehrak Anooshiravani
BACKGROUND: Children with biliary atresia are prone to developing progressive hepatic fibrosis and biliary cirrhosis following the Kasai operation. The only treatment is liver transplantation. OBJECTIVE: To assess liver fibrosis by acoustic radiation force impulse elastography (ARFI) in children who had Kasai operation, with the goal of identifying an ARFI value cut-off for children requiring liver transplantation. MATERIALS AND METHODS: Of the 32 post-Kasai children included, 19 were transplanted or listed for transplantation (group A), while 13 were not on the list during their follow-up (group B)...
June 2016: Pediatric Radiology
Sara Bignulin, Edmondo Falleti, Sara Cmet, Dario Cappello, Annarosa Cussigh, Ilaria Lenisa, Denis Dissegna, Fabio Pugliese, Cinzia Vivarelli, Carlo Fabris, Carlo Fabris, Pierluigi Toniutto
UNLABELLED:  Background and rationale. Acoustic radiation force impulse (ARFI) is a non-invasive tool used in the evaluation of liver fibrosis in HCV positive immune-competent patients. This study aimed to assess the accuracy of ARFI in discriminating liver transplanted patients with different graft fibrosis severity and to verify whether ARFI, eventually combined with non-invasive biochemical tests, could spare liver biopsies. This prospective study included 51 HCV positive liver transplanted patients who consecutively underwent to annual liver biopsy concomitantly with ARFI and blood chemistry tests measurements needed to calculate several non-invasive liver fibrosis tests...
March 2016: Annals of Hepatology
Qin-Zhi Deng, Ting Cai, Shun Zhang, Ai-Rong Hu, Xing-Fen Zhang, Jian-Rong Huang
OBJECTIVE: To perform a prospective study the effects of autologous peripheral blood stem cell (APBSC) transplantation on acoustic radiation force impulse (ARFI) in patients with hepatitis B virus (HBV)-related decompensated cirrhosis. METHODS: A total of 68 hospitalized patients with HBV-related decompensated cirrhosis undergoing conventional treatment were included in the study. Thirty-three of these patients also received APBSC transplantation therapy (treatment group) and 35 did not (control group)...
November 2015: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Juhan Lee, Young Taik Oh, Dong Jin Joo, Bo Gyoung Ma, A-lan Lee, Jae Geun Lee, Seung Hwan Song, Seung Up Kim, Dae Chul Jung, Yong Eun Chung, Yu Seun Kim
Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study...
September 2015: Medicine (Baltimore)
Hirofumi Tomita, Yasushi Fuchimoto, Kiyoshi Ohkuma, Ken Hoshino, Akihiro Fujino, Mototoshi Kato, Takumi Fujimura, Hideo Ishihama, Nobuhiro Takahashi, Yutaka Tanami, Seishi Nakatsuka, Hirotoshi Ebinuma, Hidetsugu Saito, Masahiro Shinoda, Yuko Kitagawa, Tatsuo Kuroda
BACKGROUND: Living donor liver transplantation in children often results in venous complications, leading to portal hypertension. Spleen stiffness measurements have been recently proposed as a new, noninvasive parameter for portal hypertension in cirrhotic patients. OBJECTIVE: To evaluate the diagnostic value of spleen stiffness measurements by acoustic radiation force impulse (ARFI) imaging in diagnosing venous complications after pediatric living donor liver transplantation...
April 2015: Pediatric Radiology
Dane Wildner, Deike Strobel, Peter C Konturek, Rüdiger S Görtz, Roland S Croner, Markus F Neurath, Steffen Zopf
BACKGROUND: Acoustic radiation force impulse (ARFI) elastography is a reliable diagnostic device for quantitative non-invasive assessment of liver fibrosis in patients with chronic liver disease. The aim of our prospective study was to evaluate the impact of ARFI in patients after orthotopic liver transplantation (OLT). Therefore, we compared ARFI shear wave velocities with clinical features, non-invasive markers, and the histology of patients following OLT. MATERIAL AND METHODS: Post-transplant patients underwent a clinical examination and blood samples were taken...
October 24, 2014: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hideki Ijichi, Ken Shirabe, Yoshihiro Matsumoto, Tomoharu Yoshizumi, Toru Ikegami, Hiroto Kayashima, Kazutoyo Morita, Takeo Toshima, Yohei Mano, Yoshihiko Maehara
Acoustic radiation force impulse (ARFI) imaging is an ultrasound-based modality to evaluate tissue stiffness using short-duration acoustic pulses in the region of interest. Virtual touch tissue quantification (VTTQ), which is an implementation of ARFI, allows quantitative assessment of tissue stiffness. Twenty recipients who underwent living donor liver transplantation (LDLT) for chronic liver diseases were enrolled. Graft types included left lobes with the middle hepatic vein and caudate lobes (n = 11), right lobes (n = 7), and right posterior segments (n = 2)...
November 2014: Clinical Transplantation
C C Liao, T Y Chen, L C Tsang, S Y Ou, C Y Yu, H W Hsu, Y F Cheng, K W Chiu, H L Eng, C L Chen, T L Huang
BACKGROUND: The acoustic radiation force impulse elastography (ARFI) is a new technology of elastography integrated into B-mode ultrasonography. It has been a reliable method to evaluate liver fibrosis of chronic liver disease in recent years, but less applied in the posttransplantation liver. The aim of the study was to evaluate liver fibrosis by the ARFI with correlation of pathological stages in living donor liver transplantation (LDLT). MATERIALS AND METHODS: From August 2010 to August 2012, there were 57 LDLT patients with liver biopsy (LB) due to posttransplantation dysfunction; all patients also received posttransplantation ARFI liver stiffness measurement (LSM) after transplantation for liver fibrosis staging...
April 2014: Transplantation Proceedings
T Karlas, J Weber, C Nehring, R Kronenberger, H Tenckhoff, J Mössner, D Niederwieser, M Tröltzsch, T Lange, V Keim
Hepatic complications contribute to morbidity and mortality after allogeneic hemopoietic SCT. Liver Doppler ultrasound and elastography represent promising methods for pretransplant risk assessment and early detection of complications. Ultrasound (liver and spleen size, liver perfusion) and elastography (transient elastography (TE); right liver lobe acoustic radiation force impulse imaging (r-ARFI); left liver lobe ARFI (l-ARFI)) were prospectively evaluated in patients with indications for allo-SCT. Measurements were performed before and repeatedly after SCT...
June 2014: Bone Marrow Transplantation
Wan-Yuan He, Yun-Jie Jin, Wen-Ping Wang, Chao-Lun Li, Zheng-Biao Ji, Cheng Yang
Acoustic radiation force impulse (ARFI) quantification, a novel ultrasound-based elastography method, has been used to measure liver fibrosis. However, few studies have been performed on the use of ARFI quantification in kidney examinations. We evaluated renal allograft stiffness using ARFI quantification in patients with stable renal function (n = 52) and those with biopsy-proven allograft dysfunction (n = 50). ARFI quantification, given as shear wave velocity (SWV), was performed. The resistance index (RI) was calculated by pulsed-wave Doppler ultrasound, and clinical and laboratory data were collected...
February 2014: Ultrasound in Medicine & Biology
Joana Pinto, Hugo Matos, Susana Nobre, Maria A Cipriano, Margarida Marques, João M S Pereira, Isabel Gonçalves, Maria J Noruegas
OBJECTIVES: Fibrosis, related to several causes, can be diagnosed in children and adolescents' liver grafts that are >1 year old. At present, liver biopsy is the gold standard for assessing liver damage in the posttransplant setting. We aimed to evaluate the accuracy of noninvasive biomarkers of fibrosis, namely, acoustic radiation force impulse (ARFI), aspartate-to-platelet ratio index, and aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio index, either alone or in combination, for predicting fibrosis in pediatric patients submitted to liver transplantation...
March 2014: Journal of Pediatric Gastroenterology and Nutrition
Hirofumi Tomita, Ken Hoshino, Yasushi Fuchimoto, Hirotoshi Ebinuma, Kiyoshi Ohkuma, Yutaka Tanami, Wenlin Du, Yohei Masugi, Naoki Shimojima, Akihiro Fujino, Motohiro Kano, Takumi Fujimura, Hideo Ishihama, Takahiro Shimizu, Minoru Tanabe, Hidetsugu Saito, Michiie Sakamoto, Toshifumi Hibi, Yuko Kitagawa, Tatsuo Kuroda
Graft fibrosis is a common finding during protocol biopsy examinations after pediatric liver transplantation. We evaluated the clinical utility of liver stiffness measurements by acoustic radiation force impulse (ARFI) imaging, a novel ultrasound-based elastography method, for assessing graft fibrosis after pediatric living donor liver transplantation (LDLT). We performed 73 liver stiffness measurements by ARFI imaging in 65 pediatric LDLT recipients through the upper midline of the abdomen (midline value) and the right intercostal space (intercostal value) around the time of protocol biopsy examinations...
November 2013: Liver Transplantation
Hideki Shima, Gaku Igarashi, Munechika Wakisaka, Shiho Hamano, Hideki Nagae, Mariko Koyama, Hiroaki Kitagawa
PURPOSE: Liver biopsy (LB) is still considered the "gold standard" for hepatological evaluation, but recently noninvasive methods have attempted to replace this invasive procedure. Recently, acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive modality to evaluate the stiffness of tissues. ARFI imaging theoretically measures liver stiffness of all the segments independently. The aim of this study was to determine whether ARFI elastography is a reliable method for predicting the severity of fibrosis in the post-operative patients with biliary atresia...
September 2012: Pediatric Surgery International
Gonzalo Crespo, Guillermo Fernández-Varo, Zoe Mariño, Gregori Casals, Rosa Miquel, Stella M Martínez, Rosa Gilabert, Xavier Forns, Wladimiro Jiménez, Miquel Navasa
BACKGROUND & AIMS: Our aim was to evaluate a serologic marker (ELF) and two ultrasound-based methods (FibroScan and ARFI), as well as their combinations, in the assessment of liver fibrosis. METHODS: One-hundred and forty-six patients (87 liver transplant recipients, 59 non-transplant patients) who underwent liver biopsy were prospectively included. We evaluated the diagnostic accuracy of FibroScan, ARFI, ELF and the combination of ELF with either ARFI or FibroScan...
August 2012: Journal of Hepatology
Maria José Noruegas, Hugo Matos, Isabel Gonçalves, Maria Augusta Cipriano, Conceição Sanches
BACKGROUND: Acoustic radiation force impulse-imaging (ARFI) uses sound waves to interrogate the mechanical stiffness of a tissue. OBJECTIVE: To determine the usefulness of ARFI for estimating liver fibrosis in children. MATERIALS AND METHODS: A prospective masked study of children with chronic liver disease (CLD) and/or before liver transplant (LT) comparing ARFI with histopathological analysis. Children with no history of liver disease served as a control group...
February 2012: Pediatric Radiology
Chang Young Son, Seung Up Kim, Woong Kyu Han, Gi Hong Choi, Hana Park, Seung Choul Yang, Jin Sub Choi, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Chae Yoon Chon, Kwang-Hyub Han
BACKGROUND AND AIM: Although several studies have investigated the normal range of liver elasticity using acoustic radiation force impulse (ARFI) elastography in healthy volunteers, they could not strictly exclude the morphological and functional liver abnormalities. The aim of this study was to identify the normal range of ARFI velocity by recruiting healthy living liver and kidney donors who passed the full laboratory tests and imaging studies. METHODS: The study prospectively enrolled 108 healthy living liver (n = 42) and kidney donors (n = 66) who were admitted for transplantation between July 2010 to April 2011...
January 2012: Journal of Gastroenterology and Hepatology
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