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Surgical site infection

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https://www.readbyqxmd.com/read/28454049/response-surface-method-optimization-of-a-novel-hypericin-formulation-in-p123-micelles-for-colorectal-cancer-and-antimicrobial-photodynamic-therapy
#1
Maiara Camotti Montanha, Larissa Lachi Silva, Fernanda Belincanta Borghi Pangoni, Gabriel Batista Cesar, Renato Sonchini Gonçalves, Wilker Caetano, Noboru Hioka, Tania Toyomi Tominaga, Márcia Edilaine Lopes Consolaro, Andréa Diniz, Elza Kimura
The photodynamic properties of Hypericin (Hyp) may be used as an alternative treatment for malignancies of the lower gastrointestinal tract and for the prevention of surgical-site infection; however, its use in photodynamic therapy has been limited because of its poor hydrosolubility. Therefore, in order to improve its water solubility and its photodynamic effect, Hyp was encapsulated in Pluronic P123 (P123) and the photodynamic effects against intestinal and epidermal bacteria and against two lineages of intestinal colon carcinoma cells were investigated...
April 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28453346/outcomes-of-surface-replacement-proximal-interphalangeal-joint-arthroplasty-through-a-volar-approach-a-prospective-study
#2
Thomas E Trumble, Dennis J Heaton
BACKGROUND: The dorsal approach to the proximal interphalangeal (PIP) joint provides the advantage of improved visualization of the articular surface, while the disadvantage of a dorsal approach is the disruption of the central slip and extensor mechanism requiring a delay in range of motion exercises. A volar approach keeps the central slip and extensor mechanism intact, allowing for early range of motion. The goal of this study was to evaluate patient outcomes of surface replacement (SR) PIP joint arthroplasty performed through a volar approach...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28449273/systematic-review-the-safety-of-vedolizumab-for-the-treatment-of-inflammatory-bowel-disease
#3
REVIEW
W A Bye, V Jairath, S P L Travis
BACKGROUND: Vedolizumab specifically recognises the α4β7 integrin and selectively blocks gut lymphocyte trafficking: potentially, it offers gut-specific immunosuppression. AIM: To review the safety of vedolizumab and summarise post-marketing data to assess if any safety concerns that differ from registration trials have emerged. METHOD: A systematic bibliographic search identified six registration trials and nine cohort studies. RESULTS: Integrated data from registration trials included 2830 vedolizumab-exposed patients (4811 person-years exposure [PYs]) and 513 placebo patients...
April 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28448262/an-unusually-large-carbuncle-of-the-temporofacial-region-demonstrating-remarkable-post-debridement-wound-healing-process-a-case-report
#4
Humaid Ahmad, Sheeraz Shakoor Siddiqui
Skin carbuncles are debilitating skin infections commonly seen in elderly patients with diabetes. These infections develop when a cluster of adjacent furuncles coalesce to form one inflammatory mass. While they commonly occur on the nape of the neck and back, rarer sites involving the face and head have been noted. Management of these rare sites is urgent because of the potential intracranial complications and the surgical outcome is often unsatisfactory due to associated facial scarring. Intraoral drainage is advocated to avoid this; however, when the carbuncle involves a larger area, debridement from the exterior is necessary...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28448204/future-research-opportunities-in-peri-prosthetic-joint-infection-prevention
#5
Elie Berbari, John Segreti, Javad Parvizi, Sandra I Berríos-Torres
Peri-prosthetic joint infection (PJI) is a serious complication of prosthetic joint arthroplasty. A better understanding and reversal of modifiable risk factors may lead to a reduction in the incidence of incisional (superficial and deep) and organ/space (e.g., PJI) surgical site infections (SSI). Recently, the Centers for Disease Control and Prevention (CDC) and the Healthcare Infection Control Practices Advisory Committee (HICPAC) published the Guideline for Prevention of Surgical Site Infection. This targeted update applies evidence-based methodology in drafting recommendations for potential strategies to reduce the risk of SSI both across surgical procedures and specifically in prosthetic joint arthroplasty...
April 27, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28448203/systematic-review-and-meta-analysis-of-randomized-controlled-trials-evaluating-prophylactic-intra-operative-wound-irrigation-for-the-prevention-of-surgical-site-infections
#6
Stijn W de Jonge, Quirine J J Boldingh, Joseph S Solomkin, Benedetta Allegranzi, Matthias Egger, E Patchen Dellinger, Marja A Boermeester
BACKGROUND: Surgical site infections (SSIs) are one of the most common hospital-acquired infections. To reduce SSIs, prophylactic intra-operative wound irrigation (pIOWI) has been advocated, although the results to date are equivocal. To develop recommendations for the new World Health Organization (WHO) SSI prevention guidelines, a systematic literature review and a meta-analysis were conducted on the effectiveness of pIOWI using different agents as a means of reducing SSI. METHODS: The PUBMED, Embase, CENTRAL, CINAHL, and WHO databases were searched...
April 27, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28448197/surgical-site-infections-and-associated-operative-characteristics
#7
Paul K Waltz, Brian S Zuckerbraun
Surgical site infection (SSI) contributes significantly to surgical morbidity. Patient factors and operative factors contribute to the risk of development of SSI. This review focuses on understanding operative characteristics that are associated with an increased risk of SSI. Much attention has been given to protocol care to reduce SSI, such as hair removal, skin preparation, and pre-operative antibiotic agents. Even with this, the appropriate antibiotic and re-dosing regimens often remain a challenge. Other operative factors such as blood loss/transfusion, emergency/urgent cases, duration of the operation, type of anesthesia, and resident involvement are also potentially modifiable to reduce the risk of SSI...
April 27, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28446556/bacteria-driven-peribronchial-lymphoid-neogenesis-in-bronchiectasis-and-cystic-fibrosis
#8
Justine Frija-Masson, Clémence Martin, Lucile Regard, Marie-Noëlle Lothe, Lhousseine Touqui, Aurélie Durand, Bruno Lucas, Diane Damotte, Marco Alifano, Isabelle Fajac, Pierre-Régis Burgel
We aimed to characterise lymphoid neogenesis in bronchiectasis and cystic fibrosis (CF) lungs and to examine the role of bacterial infection.Lymphoid aggregates were examined using immunohistochemical staining and morphometric analysis in surgical lung sections obtained from nonsmokers and patients with bronchiectasis or CF. Sterile, Pseudomonas aeruginosa- or Staphylococcus aureus-coated agarose beads were instilled intratracheally in mice. Kinetics of lymphoid neogenesis and chemokine expression were examined over 14 days...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28445378/the-impact-of-body-mass-index-on-abdominal-wall-reconstruction-outcomes-a-comparative-study
#9
Salvatore A Giordano, Patrick B Garvey, Donald P Baumann, Jun Liu, Charles E Butler
BACKGROUND: Obesity and higher body mass index may be associated with higher rates of wound healing complications and hernia recurrence rates following complex abdominal wall reconstruction. The authors hypothesized that higher body mass indexes result in higher rates of postoperative wound healing complications but similar rates of hernia recurrence in abdominal wall reconstruction patients. METHODS: The authors included 511 consecutive patients who underwent abdominal wall reconstruction with underlay mesh...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28444464/effectiveness-of-antibiotic-prophylaxis-in-non-emergency-cholecystectomy-using-data-from-a-population-based-cohort-study
#10
Ravinder S Vohra, James Hodson, Sandro Pasquali, Ewen A Griffiths
BACKGROUND: There is a variation in the administration of antibiotics prophylaxis to reduce the perceived risk of SSI in patients undergoing non-emergency cholecystectomy. The aim of this study was to determine the effectiveness of antibiotic prophylaxis following non-emergency cholecystectomy to prevent 30-day superficial surgical site infections (SSIs) using non-selected, nationally collected, prospective data. METHODS: Data were extracted from the CholeS study, which examined and independently validated the outcomes on consecutive patients following non-emergency cholecystectomy across 166 hospitals in the UK and Ireland...
April 25, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28441310/a-dose-response-curve-for-a-gram-negative-spinal-implant-infection-model-in-rabbits
#11
Joseph L Laratta, Jamal N Shillingford, Nathan Hardy, Ronald A Lehman, Lawrence G Lenke, K Daniel Riew
STUDY DESIGN: Randomized complete block animal spinal implant infection model with internal control. OBJECTIVE: To develop a spinal implant animal infection model to simulate postoperative gram-negative wound infection. SUMMARY OF BACKGROUND DATA: Implant-associated surgical site infections (SSI) remain a dreaded complication of spinal surgery. Currently, over 30% of all spine SSIs are secondary to gram-negative bacteria. Traditional animal models have utilized gram-positive inoculums to simulate postoperative infection, but there exists no model in the literature for gram-negative infection in the setting of spinal instrumentation...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28439517/incidence-and-risk-factors-for-organ-space-infection-after-radiofrequency-assisted-hepatectomy-or-ablation-of-liver-tumors-in-a-single-center-more-than-meets-the-eye
#12
Ioannis Karavokyros, Stamatios Orfanos, Anastasios Angelou, Antonia Meropouli, Dimitrios Schizas, John Griniatsos, Emmanouil Pikoulis
INTRODUCTION: Surgical site infections (SSIs) and especially organ/space infection (O/SI) after resection or ablation of liver tumors are associated with increased morbidity and mortality. A secondary blood stream infection (BSI) is considered an O/SI but the exact prevalence is unknown. We aimed to investigate the incidence of O/SI and BSIs in a cohort of consecutive patients after liver resection or ablation, to seek for a possible connection between them and to search for potential risk factors...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28439408/risk-factors-and-outcomes-of-organ-space-surgical-site-infections-after-elective-colon-and-rectal-surgery
#13
Aina Gomila, Jordi Carratalà, Daniel Camprubí, Evelyn Shaw, Josep Mª Badia, Antoni Cruz, Francesc Aguilar, Carmen Nicolás, Anna Marrón, Laura Mora, Rafel Perez, Lydia Martin, Rosa Vázquez, Ana Felisa Lopez, Enric Limón, Francesc Gudiol, Miquel Pujol
BACKGROUND: Organ-space surgical site infections (SSI) are the most serious and costly infections after colorectal surgery. Most previous studies of risk factors for SSI have analysed colon and rectal procedures together. The aim of the study was to determine whether colon and rectal procedures have different risk factors and outcomes for organ-space SSI. METHODS: A multicentre observational prospective cohort study of adults undergoing elective colon and rectal procedures at 10 Spanish hospitals from 2011 to 2014...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28438595/does-administration-of-oral-versus-intravenous-antibiotics-for-third-molar-removal-have-an-effect-on-the-incidence-of-alveolar-osteitis-or-postoperative-surgical-site-infections
#14
Matthew D Reiland, Kyle S Ettinger, Christine M Lohse, Christopher F Viozzi
PURPOSE: To compare the incidence of postoperative alveolar osteitis (AO) and surgical site infections (SSIs) in 2 separate cohorts of patients undergoing elective third molar removal: those who received postoperative oral (PO) antibiotics and those who received perioperative intravenous (IV) antibiotics. MATERIALS AND METHODS: A retrospective cohort study of all patients 14 to 30 years old undergoing elective outpatient third molar removal under a single surgeon's service over a 12-year period was completed...
March 31, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28438507/cardiothoracic-transplant-recipient-mycoplasma-hominis-an-uncommon-infection-with-probable-donor-transmission
#15
Rahul Sampath, Robin Patel, Scott A Cunningham, Sana Arif, Richard C Daly, Andrew D Badley, Mark E Wylam
The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis...
April 19, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28438400/arteriotomy-closure-devices-in-evar-tevar-and-tavr-a-systematic-review-and-meta-analysis-of-randomised-clinical-trials-and-cohort-studies
#16
REVIEW
B P Vierhout, R A Pol, M El Moumni, C J Zeebregts
OBJECTIVES: Cardiac and vascular surgery benefit from percutaneous interventions. Arteriotomy closure devices (ACDs) enable minimally invasive access to the common femoral artery (CFA). The objective of this review was to assess the differences between ACDs and surgical cut down (SCD) of the CFA regarding the number of complications, duration of surgery (DOS), and hospital length of stay (HLOS). DESIGN: A systematic literature search with predefined search terms was performed using MEDLINE, Embase, and the Cochrane Library (2000-2016)...
April 21, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28437670/a-case-report-of-invasive-candidiasis-and-fungal-osteomyelitis-mimicking-oropharyngeal-carcinoma-recurrence-in-an-immunocompetent-patient-following-transoral-robotic-surgery
#17
Hong Yu Tan, Jenny Guek-Hong Low, Elizabeth Roche, Hiang Khoon Tan
INTRODUCTION: Transoral robotic surgery(TORS) for the excision of oropharyngeal tumour is increasingly considered for its lower rates of postoperative complications and better functional outcomes. However, we report a case of invasive candidiasis in an immunocompetent patient with previous radiation therapy years ago who underwent TORS recently. CASE PRESENTATION: A 55year old Chinese female with previous radiation therapy for nasopharyngeal carcinoma diagnosed in 1986 underwent wide excision of a newly diagnosed oropharyngeal carcinoma with TORS...
April 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28437330/pedicle-screw-fluid-sign-an-indication-on-magnetic-resonance-imaging-of-a-deep-infection-after-posterior-spinal-instrumentation
#18
Hiroaki Kimura, Jitsuhiko Shikata, Seiichi Odate, Tsunemitsu Soeda
STUDY DESIGN: A single-center case-referent study. OBJECTIVE: To assess whether the "pedicle screw (PS) fluid sign" on magnetic resonance imaging (MRI) can be used to diagnose deep surgical site infection (SSI) after posterior spinal instrumentation (PSI). SUMMARY OF BACKGROUND DATA: MRI is a useful tool for the early diagnosis of a deep SSI. However, the diagnosis is frequently difficult with feverish patients with clear wounds after PSI because of artifacts from the metallic implants...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437197/pressure-irrigation-of-surgical-incisions-and-traumatic-wounds
#19
Donald E Fry
BACKGROUND: Pressure irrigation of surgical incisions and traumatic wounds is commonly used to prevent infections. Commercial pressure irrigation devices have proliferated rapidly, but scientific validation of clinical benefit or appropriate use remains uncertain. METHODS: The published experimental and clinical investigations of pressure irrigation have been reviewed since the introduction of the Waterpik device in 1967 to identify the evidence for use to prevent soft tissue infections associated with injury wounds or surgical incisions...
March 1, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28437196/surgical-site-infection-and-colorectal-surgical-procedures-a-prospective-analysis-of-risk-factors
#20
E Carter Paulson, Earl Thompson, Najjia Mahmoud
BACKGROUND: Colorectal surgical procedures (CRS) are associated with the highest surgical site infection (SSI) rate among elective operations. A wide range of patient and surgical characteristics have been identified as risk factors for SSI. Most studies are limited by reliance on retrospective data or subset analysis of data that includes CRS. This study reflects analysis of SSI risk factors using prospectively collected data in an elective CRS population. PATIENTS AND METHODS: We analyzed data prospectively collected as part of a randomized, blinded trial of skin anti-sepsis in elective CRS to identify risk factors associated with SSI, including superficial or deep SSI or cellulitis within 30 days post-discharge...
February 22, 2017: Surgical Infections
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