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https://www.readbyqxmd.com/read/28931148/previous-exposure-in-a-high-risk-area-for-travellers-diarrhoea-within-the-past-year-is-associated-with-a-significant-protective-effect-for-travellers-diarrhoea-a-prospective-observational-cohort-study-in-travellers-to-south-asia
#1
Esther Kuenzli, David Juergensen, Kerstin Kling, Veronika K Jaeger, Susan DeCrom, Robert Steffen, Andreas F Widmer, Manuel Battegay, Christoph Hatz, Andreas Neumayr
Background: Travellers' diarrhoea is the most common health problem in travellers. Depending on the region visited, up to 40% of travellers develop diarrhoea during a 2-week trip. The aim of this study was to assess risk factors for TD among travellers to the Indian subcontinent. Methods: An observational prospective multicentre cohort study investigated travellers to the Indian subcontinent. Participants completed questionnaires assessing the incidence of travellers' diarrhoea and identifying potential risk factors...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28931068/erk1-2-signalling-protects-against-apoptosis-following-endoplasmic-reticulum-stress-but-cannot-provide-long-term-protection-against-bax-bak-independent-cell-death
#2
Nicola J Darling, Kathryn Balmanno, Simon J Cook
Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed through the cell intrinsic, mitochondrial pathway. Indeed, cells that lack the key executioner proteins BAX and BAK are protected from ER stress-induced apoptosis. Here we show that chronic ER stress causes the progressive inhibition of the extracellular signal-regulated kinase (ERK1/2) signalling pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28931041/lactobacillus-paracasei-feeding-improves-immune-control-of-influenza-infection-in-mice
#3
Nouria Belkacem, Nicolas Serafini, Richard Wheeler, Muriel Derrien, Lilia Boucinha, Aurélie Couesnon, Nadine Cerf-Bensussan, Ivo Gomperts Boneca, James P Di Santo, Muhamed-Kkeir Taha, Raphaëlle Bourdet-Sicard
Respiratory tract infections such as flu cause severe morbidity and mortality and are among the leading causes of death in children and adults worldwide. Commensal microbiota is critical for orchestrating tissue homeostasis and immunity in the intestine. Probiotics represent an interesting source of immune modulators and several clinical studies have addressed the potential beneficial effects of probiotics against respiratory infections. Therefore, we have investigated the mechanisms of protection conferred by L...
2017: PloS One
https://www.readbyqxmd.com/read/28931035/neuroprotection-with-hypothermia-and-allopurinol-in-an-animal-model-of-hypoxic-ischemic-injury-is-it-a-gender-question
#4
Javier Rodríguez-Fanjul, Cristina Durán Fernández-Feijóo, Míriam Lopez-Abad, Maria Goretti Lopez Ramos, Rafael Balada Caballé, Soledad Alcántara-Horillo, Marta Camprubí Camprubí
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term newborns after perinatal hypoxic ischemic injury (HI). Despite this, TH does not provide complete neuroprotection. Allopurinol seems to be a good neuroprotector in several animal studies, but it has never been tested in combination with hypothermia. Clinical findings show that male infants with (HI) fare more poorly than matched females in cognitive outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28930691/dna-methylome-analysis-identifies-transcription-factor-based-epigenomic-signatures-of-multilineage-competence-in-neural-stem-progenitor-cells
#5
Tsukasa Sanosaka, Takuya Imamura, Nobuhiko Hamazaki, MuhChyi Chai, Katsuhide Igarashi, Maky Ideta-Otsuka, Fumihito Miura, Takashi Ito, Nobuyuki Fujii, Kazuho Ikeo, Kinichi Nakashima
Regulation of the epigenome during in vivo specification of brain stem cells is still poorly understood. Here, we report DNA methylome analyses of directly sampled cortical neural stem and progenitor cells (NS/PCs) at different development stages, as well as those of terminally differentiated cortical neurons, astrocytes, and oligodendrocytes. We found that sequential specification of cortical NS/PCs is regulated by two successive waves of demethylation at early and late development stages, which are responsible for the establishment of neuron- and glia-specific low-methylated regions (LMRs), respectively...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28930377/epigenetics-the-future-direction-in-systemic-sclerosis
#6
REVIEW
M Walczyk, A Paradowska-Gorycka, M Olesinska
Systemic sclerosis (SSc) is an immune-mediated connective tissue disease of which the aetiology is still unclear. Previous genetic studies including candidate-gene studies and genomewide association studies have identified a number of genetic variations that confer risk to SSc. However, these variants, such as single nucleotide polymorphisms, cannot completely explain the SSc susceptibility and the diversity in the clinical symptoms of SSc patients. The contribution of epigenetic mechanisms as a link between genetics and environmental triggers represents promising field in understanding the pathogenesis of SSc...
August 21, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28930278/literature-review-of-research-on-chronic-pain-and-yoga-in-military-populations
#7
REVIEW
Shari Miller, Susan Gaylord, Alex Buben, Carrie Brintz, Kristine Rae Olmsted, Nakisa Asefnia, Michael Bartoszek
Background: Although yoga is increasingly being provided to active duty soldiers and veterans, studies with military populations are limited and effects on chronic pain are largely unknown. We reviewed the existing body of literature and provide recommendations for future research. Methods: We conducted a literature review of electronic databases (PubMed, PsychINFO, Web of Science, Science Citation Index Expanded, Social Sciences Citation Index, Conference Proceedings Citation Index-Science, and Conference Proceedings Citation Index-Social Science & Humanities)...
September 1, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930104/liver-transplantation-in-the-obese-cirrhotic-patient
#8
Erin K Spengler, Jacqueline G O'Leary, Helen S Te, Shari Rogal, Anjana A Pillai, Abdullah Al-Osaimi, Archita Desai, James N Fleming, Daniel Ganger, Anil Seetharam, Georgios Tsoulfas, Martin Montenovo, Jennifer C Lai
Despite the rapidly increasing prevalence of obesity in the transplant population, the optimal management of obese liver transplant candidates remains undefined. Setting strict body mass index cutoffs for transplant candidacy remains controversial, with limited data to guide this practice. Body mass index is an imperfect measure of surgical risk in this population, partly due to volume overload and variable visceral adiposity. Weight loss before transplantation may be beneficial, but it remains important to avoid protein calorie malnutrition and sarcopenia...
October 2017: Transplantation
https://www.readbyqxmd.com/read/28930057/tlr4-methylation-moderates-the-relationship-between-alcohol-use-severity-and-gray-matter-loss
#9
Hollis C Karoly, Rachel E Thayer, Sarah L Hagerty, Kent E Hutchison
OBJECTIVE: Alcohol use disorders (AUDs) are associated with decreased gray matter, and neuroinflammation is one mechanism through which alcohol may confer such damage, given that heavy alcohol use may promote neural damage via activation of toll-like receptor 4 (TLR4)-mediated inflammatory signaling cascades. We previously demonstrated that TLR4 is differentially methylated in AUD compared with control subjects, and the present study aims to extend this work by examining whether TLR4 methylation moderates the relationship between alcohol use and gray matter...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28929857/the-mentorship-imperative-for-health-leadership
#10
Nadia Batara, Tony Woolgar
Mentorship plays an important role in supporting the career development of health leaders. An examination of mentorship programs in different organizational settings provides a frame of reference to discuss and explore personal and professional mentorship experiences. Specifically, between October 2015 and April 2016, the Emerging Health Leaders (EHL) National Health Leadership Conference (NHLC) working group collaborated on an environmental scan of mentorship programs and activities to understand innovations in mentorship...
May 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929704/-sixth-ministerial-conference-on-environment-and-health-results-and-perspectives
#11
EDITORIAL
Marco Martuzzi
No abstract text is available yet for this article.
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929635/association-between-interferon-induced-helicase-ifih1-rs1990760-polymorphism-and-seasonal-variation-in-the-onset-of-type-1-diabetes-mellitus-ifih1-polymorphism-and-type-1-diabetes-onset
#12
Ágnes Jermendy, Ildikó Szatmári, Anna Körner, Attila J Szabó, Péter Tóth-Heyn, Róbert Hermann
BACKGROUND: Infections, mostly of viral origin, may contribute to the seasonal variation in the onset of type 1 diabetes mellitus (T1DM). The rs1990760 (A>G, Ala946Thr) polymorphism (GG genotype) of the interferon induced helicase (IFIH1), a virus recognition receptor, confers a modest protection for T1DM. The aim of our study was to evaluate a possible association between this IFIH1 polymorphism and the seasonal variation in the onset of T1DM. MATERIALS AND METHODS: The IFIH1 rs1990760 polymorphism was genotyped in 1055 patients of Central-Eastern European ancestry with T1DM (median age at diagnosis: 8...
September 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28929570/impacts-of-human-induced-environmental-change-in-wetlands-on-aquatic-animals
#13
Michael Sievers, Robin Hale, Kirsten M Parris, Stephen E Swearer
Many wetlands harbour highly diverse biological communities and provide extensive ecosystem services; however, these important ecological features are being altered, degraded and destroyed around the world. Despite a wealth of research on how animals respond to anthropogenic changes to natural wetlands and how they use created wetlands, we lack a broad synthesis of these data. While some altered wetlands may provide vital habitat, others could pose a considerable risk to wildlife. This risk will be heightened if such wetlands are ecological traps - preferred habitats that confer lower fitness than another available habitat...
September 19, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28929459/revisiting-ovarian-cancer-microenvironment-a-friend-or-a-foe
#14
REVIEW
Boyi Zhang, Fei Chen, Qixia Xu, Liu Han, Jiaqian Xu, Libin Gao, Xiaochen Sun, Yiwen Li, Yan Li, Min Qian, Yu Sun
Development of ovarian cancer involves the co-evolution of neoplastic cells together with the adjacent microenvironment. Steps of malignant progression including primary tumor outgrowth, therapeutic resistance, and distant metastasis are not determined solely by genetic alterations in ovarian cancer cells, but considerably shaped by the fitness advantage conferred by benign components in the ovarian stroma. As the dynamic cancer topography varies drastically during disease progression, heterologous cell types within the tumor microenvironment (TME) can actively determine the pathological track of ovarian cancer...
September 19, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28929448/acid-rock-drainage-in-nevado-pastoruri-glacier-area-huascar%C3%A3-n-national-park-per%C3%A3%C2%BA-hydrochemical-and-mineralogical-characterization-and-associated-environmental-implications
#15
Esther Santofimia, Enrique López-Pamo, Edwin Julio Palomino, Elena González-Toril, Ángeles Aguilera
The generation of acid rock drainage (ARD) was observed in an area of Nevado Pastoruri as a result of the oxidative dissolution of pyrite-rich lutites and sandstones. These ARDs are generated as abundant pyrite becomes exposed to atmospheric conditions as a result of glacier retreat. The proglacial zone contains lagoons, springs, streams and wetlands, scant vegetation, and intense fluvioglacial erosion. This work reports a comprehensive identification and the results of sampling of the lagoons and springs belonging to the microbasin, which is the headwaters of the Pachacoto River, as well as mapping results based on the hydrochemical data obtained in our study...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28929317/risk-alleles-for-iga-nephropathy-associated-snps-conferred-completely-opposite-effects-to-idiopathic-membranous-nephropathy-in-chinese-han
#16
Xiaosong Qin, Chen Wang, Guanting Lu, Mengle Peng, Guixue Cheng, Hongquan Zhu, Yun Cao, Jianhua Liu, Yuzhong Li, Hong Cai, Funing Yang, Yanhong Liu, Xiaoyu Chen, Liubing Li, Nan Wan, Xiaoting Wen, Shijun Li, Ruili Nie, Dongchun Qin, Yongzhe Li, Yong Liu
The coexistence of immunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN) in a few cases suggested that there could be existed a similar mechanism in pathogenesis of these two types of primary glomerulonephritis. In order to verify this hypothesis, a total of 23 reported IgAN-associated SNPs were genotyped in a cohort of 485 IMN patients and 569 healthy controls with Chinese Han origin. After Cochran-Armitage test for trend analysis, seven IgAN-associated SNPs located in the major histocompatibility complex (MHC) region were found to be significantly associated with the susceptibility of IMN, with rs9275596 as the top one (p = 1...
September 19, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28929313/an-anti-propionibacterium-acnes-antibody-shows-heterologous-resistance-to-an-actinobacillus-pleuropneumoniae-infection-independent-of-neutrophils-in-mice
#17
Jian-Fang Liu, Qiu-Yue Ma, Ri-Ning Zhu, Meng-Jun Cheng, Chun-Tong Bao, Jing-Min Gu, Chang-Jiang Sun, Paul Richard Langford, Wen-Yu Han, Lian-Cheng Lei
Porcine contagious pleuropneumonia is a highly fatal respiratory disease that is caused by Actinobacillus pleuropneumoniae (APP) and results in tremendous economic losses for the pig breeding industry worldwide. Previous studies have demonstrated that Propionibacterium acnes (PA) could effectively prevent APP infection in mice and pigs. The humoral immune response played a primary role during this process and anti-PA antibody could mediate macrophages to kill the bacteria. However, the role of neutrophils in this process is currently unknown...
September 20, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28929252/knowledge-about-cervical-cancer-risk-factors-and-practices-of-pap-testing-among-turkish-immigrant-women-in-the-united-states
#18
Aynur Uysal Toraman, Nilufer Yildirim
The objective of this study was to examine knowledge about cervical cancer risk factors and practices of Pap testing among female Turkish immigrants in the state of Florida in the United States of America (USA). This descriptive study was conducted between April and September 2012. The study sampling was consist of 156 Turkish women living in the state of Florida. A questionnaire-based survey was conducted among the population of Turkish immigrant women. On the survey form comprised of a total of 37 questions and three sections there are questions pertaining to the socio-demographic characteristics of the individuals, their knowledge on the cervical cancer risk factors and their approach to getting Pap smear tests...
September 19, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28929089/two-novel-salmonella-bivalent-vaccines-confer-dual-protection-against-two-salmonella-serovars-in-mice
#19
Xinxin Zhao, Qinlong Dai, Renyong Jia, Dekang Zhu, Mafeng Liu, Mingshu Wang, Shun Chen, Kunfeng Sun, Qiao Yang, Ying Wu, Anchun Cheng
Non-typhoidal Salmonella includes thousands of serovars that are leading causes of foodborne diarrheal illness worldwide. In this study, we constructed three bivalent vaccines for preventing both Salmonella Typhimurium and Salmonella Newport infections by using the aspartate semialdehyde dehydrogenase (Asd)-based balanced-lethal vector-host system. The constructed Asd(+) plasmid pCZ11 carrying a subset of the Salmonella Newport O-antigen gene cluster including the wzx-wbaR-wbaL-wbaQ-wzy-wbaW-wbaZ genes was introduced into three Salmonella Typhimurium mutants: SLT19 (Δasd) with a smooth LPS phenotype, SLT20 (Δasd ΔrfbN) with a rough LPS phenotype, and SLT22 (Δasd ΔrfbN ΔpagL::T araC PBADrfbN) with a smooth LPS phenotype when grown with arabinose...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28929052/simultaneous-determination-of-rutin-isoquercetin-and-quercetin-flavonoids-in-nelumbo-nucifera-by-high-performance-liquid-chromatography-method
#20
P Naveen, H B Lingaraju, Anitha, K Shyam Prasad
OBJECTIVE: The present study was investigated to provide a documentary evidence for the determination of rutin, isoquercetin, and quercetin flavonoids from the flora of Nelumbo nucifera by reversed-phase high-performance liquid chromatography (RP-HPLC). MATERIALS AND METHODS: RP-HPLC analysis was performed by gradient elution with a low-pressure gradient using 0.5% acetic acid: acetonitrile as a mobile phase with a flow rate of 1.0 ml/min. The separation was done at 26°C using a Kinetex XB-C18 column as stationary phase and the detection wavelength at 356 nm...
April 2017: International Journal of Pharmaceutical Investigation
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