Lin Gao, Sumei Hu, Dengbao Yang, Lu Wang, Jacques Togo, Yingga Wu, Baoguo Li, Min Li, Guanlin Wang, Xueying Zhang, Li Li, Yanchao Xu, Moshen Mazidi, Elspeth Couper, Andrew Whittington-Davies, Chaoqun Niu, John R Speakman
OBJECTIVE: High-fat diets cause obesity in male mice; however, the underlying mechanisms remain controversial. Here, three contrasting ideas were assessed: hedonic overdrive, reverse causality, and passive overconsumption models. METHODS: A total of 12 groups of 20 individually housed 12-week-old C57BL/6 male mice were exposed to 12 high-fat diets with varying fat content from 40% to 80% (by calories), protein content from 5% to 30%, and carbohydrate content from 8...
February 27, 2024: Obesity