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https://www.readbyqxmd.com/read/27918289/a-bioreactor-with-an-electro-responsive-elastomeric-membrane-for-mimicking-intestinal-peristalsis
#1
Daniele Cei, Joana Costa, Giulia Gori, Gabriele Frediani, Claudio Domenici, Federico Carpi, Arti Ahluwalia
This study describes an actuated bioreactor which mimics the pulsatile contractile motion of the intestinal barrier using electro-responsive elastomers as smart materials that undergo deformation upon electrical stimulation. The device consists of an annular dielectric elastomer actuator working as a radial artificial muscle able to rhythmically contract and relax a central cell culture well. The bioreactor maintained up to 4 h of actuation at a frequency of 0.15 Hz and a strain of 8%-10%, to those of the cyclic contraction and relaxation of the small intestine...
December 5, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27917819/pulsatile-flow-conditioning-of-three-dimensional-bioengineered-cardiac-ventricle
#2
Nikita M Patel, Ravi K Birla
Current physical stimuli mechanical stretch bioreactor studies focus on conditioning planar and/or tubular engineered cardiac constructs. The current 3D bioreactor models in cardiac tissue engineering use differential pressure loading for structural support as opposed to conditioning. The development of the pulsatile flow conditioned ventricle (PFCV) provides a 3D mechanical stretch conditioning method to generate pump function in the engineered cardiac left ventricle. The study utilizes a chitosan bioengineered open ventricle scaffold, to produce the in vitro PFCV model...
December 5, 2016: Biofabrication
https://www.readbyqxmd.com/read/27905315/spray-coated-carbon-nanotube-carpets-for-creeping-reduction-of-conducting-polymer-based-artificial-muscles
#3
Aiva Simaite, Aude Delagarde, Bertrand Tondu, Philippe Souères, Emmanuel Flahaut, Christian Bergaud
During cyclic actuation, conducting polymer based artificial muscles are often creeping from the initial movement range. One of the likely reasons of such behaviour is unbalanced charging during conducting polymer oxidation and reduction. To improve the actuation reversibility and subsequently the long time performance of ionic actuators, we suggest using spray-coated carbon nanotube (CNT) carpets on the surface of the conducting polymer electrodes. We show that carbon nanotubes facilitate a conducting polymer redox reaction and improve its reversibility...
December 1, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27896920/fusion-of-ssm6a-with-a-protein-scaffold-retains-selectivity-on-nav-1-7-and-improves-its-therapeutic-potential-against-chronic-pain
#4
Chuan Wang, Bin Shan, Qiong Wang, Qunyuan Xu, Hailin Zhang, Huimeng Lei
Voltage gated sodium channel NaV 1.7 serves an attractive target for chronic pain treatment. Several venom peptides were found to selectively inhibit NaV 1.7 but with intrinsic problems. Among them, Ssm6a, a recently discovered centipede venom peptide, shows the greatest selectivity against NaV 1.7, but dissociates from the target too fast and loses bioactivity in synthetic forms. As a disulfide-rich venom peptide, it is difficult to optimize Ssm6a by artificial mutagenesis and produce the peptide with common industrial manufacturing methods...
November 29, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27878864/multidirectional-artificial-muscles-from-nylon
#5
Seyed M Mirvakili, Ian W Hunter
Multidirectional artificial muscles are made from highly oriented nylon filaments. Thanks to the low thermal conductivity of nylon and its anisotropic thermal expansion, bending occurs when a nylon beam is differentially heated. This heat can be generated via a Joule heating mechanism or high power laser pulses.
November 23, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27870858/first-report-of-the-occurrence-of-trichinella-specific-antibodies-in-domestic-pigs-in-central-and-eastern-uganda
#6
Kristina Roesel, Karsten Nöckler, Maximilian P O Baumann, Reinhard Fries, Michel M Dione, Peter-Henning Clausen, Delia Grace
Previous research on trichinellosis in Africa focused on isolating Trichinella from wildlife while the role of domestic pigs has remained highly under-researched. Pig keeping in Uganda is historically recent, and evidence on zoonotic pig diseases, including infection with Trichinella species, is scarce. A cross-sectional survey on Trichinella seroprevalence in pigs was conducted in three districts in Central and Eastern Uganda from April 2013 to January 2015. Serum from a random sample of 1125 pigs from 22 villages in Eastern and Central Uganda was examined to detect immunoglobulin G (IgG) against any Trichinella spp...
2016: PloS One
https://www.readbyqxmd.com/read/27857067/one-volt-driven-superfast-polymer-actuators-based-on-single-ion-conductors
#7
Onnuri Kim, Hoon Kim, U Hyeok Choi, Moon Jeong Park
The key challenges in the advancement of actuator technologies related to artificial muscles include fast-response time, low operation voltages and durability. Although several researchers have tackled these challenges over the last few decades, no breakthrough has been made. Here we describe a platform for the development of soft actuators that moves a few millimetres under 1 V in air, with a superfast response time of tens of milliseconds. An essential component of this actuator is the single-ion-conducting polymers that contain well-defined ionic domains through the introduction of zwitterions; this achieved an exceptionally high dielectric constant of 76 and a 300-fold enhancement in ionic conductivity...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27853413/using-lempel-ziv-complexity-to-assess-ecg-signal-quality
#8
Yatao Zhang, Shoushui Wei, Costanzo Di Maria, Chengyu Liu
The poor quality of wireless electrocardiography (ECG) recordings can lead to misdiagnosis and waste of medical resources. This study presents an interpretation of Lempel-Ziv (LZ) complexity in terms of ECG quality assessment, and verifies its performance on real ECG signals. Firstly, LZ complexities for typical signals, namely high-frequency (HF) noise, low-frequency (LF) noise, power-line (PL) noise, impulse (IM) noise, clean artificial ECG signals, and ECG signals with various types of noise added (ECG plus HF, LF, PL, and IM noise, respectively) were analyzed...
2016: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/27852938/does-maternal-exposure-to-artificial-food-coloring-additives-increase-oxidative-stress-in-the-skin-of-rats
#9
K Başak, P Y Başak, D K Doğuç, F Aylak, S Oğuztüzün, B M Bozer, F Gültekin
Glutathione-S-transferase (GST) and cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) metabolize and detoxify carcinogens, drugs, environmental pollutants, and reactive oxygen species. Changes of GST expression in tissues and gene mutations have been reported in association with many neoplastic skin diseases and dermatoses. Widely used artificial food coloring additives (AFCAs) also reported to effect primarily behavioral and cognitive function and cause neoplastic diseases and several inflammatory skin diseases...
November 16, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27832605/bdnf-effects-on-functional-recovery-across-motor-behaviors-after-cervical-spinal-cord-injury
#10
Vivian Hernandez-Torres, Heather M Gransee, Carlos B Mantilla, Yao Wang, Wen-Zhi Zhan, Gary C Sieck
Unilateral C2 cervical spinal cord hemisection (SH) disrupts descending excitatory drive to phrenic motor neurons, thereby paralyzing the ipsilateral diaphragm muscle (DIAm) during ventilatory behaviors. Recovery of rhythmic DIAm activity ipsilateral to injury occurs over time, consistent with neuroplasticity and strengthening of spared synaptic inputs to phrenic motor neurons. Localized intrathecal delivery of brain-derived neurotrophic factor (BDNF) to phrenic motor neurons after SH enhances recovery of eupneic DIAm activity...
November 9, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27811379/improving-actuation-efficiency-through-variable-recruitment-hydraulic-mckibben-muscles-modeling-orderly-recruitment-control-and-experiments
#11
Michael Meller, Jordan Chipka, Alexander Volkov, Matthew Bryant, Ephrahim Garcia
Hydraulic control systems have become increasingly popular as the means of actuation for human-scale legged robots and assistive devices. One of the biggest limitations to these systems is their run time untethered from a power source. One way to increase endurance is by improving actuation efficiency. We investigate reducing servovalve throttling losses by using a selective recruitment artificial muscle bundle comprised of three motor units. Each motor unit is made up of a pair of hydraulic McKibben muscles connected to one servovalve...
November 3, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27807418/evaluating-emg-feature-and-classifier-selection-for-application-to-partial-hand-prosthesis-control
#12
Adenike A Adewuyi, Levi J Hargrove, Todd A Kuiken
Pattern recognition-based myoelectric control of upper-limb prostheses has the potential to restore control of multiple degrees of freedom. Though this control method has been extensively studied in individuals with higher-level amputations, few studies have investigated its effectiveness for individuals with partial-hand amputations. Most partial-hand amputees retain a functional wrist and the ability of pattern recognition-based methods to correctly classify hand motions from different wrist positions is not well studied...
2016: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/27799908/assessment-of-myoelectric-controller-performance-and-kinematic-behavior-of-a-novel-soft-synergy-inspired-robotic-hand-for-prosthetic-applications
#13
Simone Fani, Matteo Bianchi, Sonal Jain, José Simões Pimenta Neto, Scott Boege, Giorgio Grioli, Antonio Bicchi, Marco Santello
Myoelectric artificial limbs can significantly advance the state of the art in prosthetics, since they can be used to control mechatronic devices through muscular activity in a way that mimics how the subjects used to activate their muscles before limb loss. However, surveys indicate that dissatisfaction with the functionality of terminal devices underlies the widespread abandonment of prostheses. We believe that one key factor to improve acceptability of prosthetic devices is to attain human likeness of prosthesis movements, a goal which is being pursued by research on social and human-robot interactions...
2016: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/27784624/multiple-sequence-alignment-using-multi-objective-based-bacterial-foraging-optimization-algorithm
#14
R Ranjani Rani, D Ramyachitra
Multiple sequence alignment (MSA) is a widespread approach in computational biology and bioinformatics. MSA deals with how the sequences of nucleotides and amino acids are sequenced with possible alignment and minimum number of gaps between them, which directs to the functional, evolutionary and structural relationships among the sequences. Still the computation of MSA is a challenging task to provide an efficient accuracy and statistically significant results of alignments. In this work, the Bacterial Foraging Optimization Algorithm was employed to align the biological sequences which resulted in a non-dominated optimal solution...
October 23, 2016: Bio Systems
https://www.readbyqxmd.com/read/27779830/construction-and-histological-analysis-of-a-3d-human-arterial-wall-model-containing-vasa-vasorum-using-a-layer-by-layer-technique
#15
Fumiaki Shima, Hirokazu Narita, Ayami Hiura, Hiroshi Shimoda, Mitsuru Akashi
There is considerable global demand for three-dimensional (3D) functional tissues which mimic our native organs and tissues for use as in vitro drug screening systems and in regenerative medicine. In particular, there has been an increasing number of patients who suffer from arterial diseases such as arteriosclerosis. As such, in vitro 3D arterial wall models that can evaluate the effects of novel medicines and a novel artificial graft for the treatment are required. In our previous study, we reported the rapid construction of 3D tissues by employing a Layer-by-Layer (LbL) technique and revealed their potential applications in the pharmaceutical fields and tissue engineering...
October 25, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27775538/a-system-for-electrotactile-feedback-using-electronic-skin-and-flexible-matrix-electrodes-experimental-evaluation
#16
Marta Franceschi, Lucia Seminara, Strahinja Dosen, Matjia Strbac, Maurizio Valle, Dario Farina
Myoelectric prostheses are successfully controlled using muscle electrical activity, thereby restoring lost motor functions. However, the somatosensory feedback from the prosthesis to the user is still missing. The sensory substitution methods described in the literature comprise mostly simple position and force sensors combined with discrete stimulation units. The present study describes a novel system for sophisticated electrotactile feedback integrating advanced distributed sensing (electronic skin) and stimulation (matrix electrodes)...
October 19, 2016: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/27751874/high-density-collagen-patch-prevents-stricture-after-endoscopic-circumferential-submucosal-dissection-of-the-esophagus-a-porcine-model
#17
Shigehisa Aoki, Yasuhisa Sakata, Ryo Shimoda, Toshiaki Takezawa, Ayumi Oshikata-Miyazaki, Hiromi Kimura, Mihoko Yamamoto, Ryuichi Iwakiri, Kazuma Fujimoto, Shuji Toda
BACKGROUND AND AIMS: Extensive excision of the esophageal mucosa by endoscopic submucosal dissection (ESD) frequently evokes a luminal stricture. This study aimed to determine the efficacy of a high-density collagen patch for the prevention of esophageal stricture in extensive ESD. METHODS: Six pigs underwent circumferential esophageal ESD under general anesthesia. In 3 pigs, artificial ulcers were covered by 2 collagen patches. The other 3 pigs underwent circumferential ESD only...
October 14, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27744680/high-performance-multi-responsive-paper-actuators
#18
Morteza Amjadi, Metin Sitti
There is an increasing demand for soft actuators because of their importance in soft robotics, artificial muscles, biomimetic devices, and beyond. However, the development of soft actuators capable of low-voltage operation, powerful actuation, and programmable shape-changing is still challenging. In this work, we propose programmable bilayer actuators that operate based on the large hygroscopic contraction of the copy paper and simultaneously large thermal expansion of the polypropylene film upon increasing the temperature...
October 16, 2016: ACS Nano
https://www.readbyqxmd.com/read/27744200/toxicological-hazard-induced-by-sucralose-to-environmentally-relevant-concentrations-in-common-carp-cyprinus-carpio
#19
Karinne Saucedo-Vence, Armando Elizalde-Velázquez, Octavio Dublán-García, Marcela Galar-Martínez, Hariz Islas-Flores, Nely SanJuan-Reyes, Sandra García-Medina, María Dolores Hernández-Navarro, Leobardo Manuel Gómez-Oliván
Sucralose (SUC) is an artificial sweetener that is now widely used in North American and Europe; it has been detected in a wide variety of aquatic environments. It is considered safe for human consumption but its effects in the ecosystem have not yet been studied in depth, since limited ecotoxicological data are available in the peer-reviewed literature. This study aimed to evaluate potential SUC-induced toxicological hazard in the blood, brain, gill, liver and muscle of Cyprinus carpio using oxidative stress biomarkers...
October 13, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27740656/shape-memory-polymer-nanocomposites-with-a-3d-conductive-network-for-bidirectional-actuation-and-locomotion-application
#20
Qingyu Peng, Hongqiu Wei, Yuyang Qin, Zaishan Lin, Xu Zhao, Fan Xu, Jinsong Leng, Xiaodong He, Anyuan Cao, Yibin Li
Electrical stimulation of shape-memory polymers (SMPs) has many advantages over thermal methods; creating an efficient conductive path through the bulk polymers is essential for developing high performance electroactive systems. Here, we show that a three-dimensional (3D) porous carbon nanotube sponge can serve as a built-in integral conductive network to provide internal, homogeneous, in situ Joule heating for shape-memory polymers, thus significantly improving the mechanical and thermal behavior of SMPs. As a result, the 3D nanocomposites show a fast response and produce large exerting forces (with a maximum flexural stress of 14...
October 14, 2016: Nanoscale
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