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mucinous ovarian tumor

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https://www.readbyqxmd.com/read/29451304/distinct-methylation-profile-of-mucinous-ovarian-carcinoma-reveals-susceptibility-to-proteasome-inhibitors
#1
Phui-Ly Liew, Rui-Lan Huang, Yu-Chun Weng, Chia-Lang Fang, Tim Hui-Ming Huang, Hung-Cheng Lai
Mucinous type of epithelial ovarian cancer (MuOC) is a unique subtype with a poor survival outcome in recurrent and advanced stages. The role of type-specific epigenomics and its clinical significance remain uncertain. We analyzed the methylomic profiles of six benign mucinous adenomas, 24 MuOCs, 103 serous type of epithelial ovarian cancers (SeOCs), and 337 nonepithelial ovarian cancers. MuOC and SeOC exhibited distinct DNA methylation profiles comprising 101 genes, 81 of which exhibited low methylation in MuOC and were associated with the response to glucocorticoid, ATP hydrolysis-coupled proton transport, proteolysis involved in the cellular protein catabolic process, and ion transmembrane transport...
February 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29434957/experience-based-surgical-approach-to-pancreatic-mucinous-cystic-neoplasms-with-ovarian-type-stroma
#2
Chang Moo Kang, Akira Matsushita, Ho Kyoung Hwang, Yoko Matsuda, Hyunki Kim, Yoshiharu Nakamura, Woo Jung Lee
The present study aimed to elucidate the clinicopathological characteristics of resected mucinous cystic neoplasm (MCN) with ovarian-type stroma and identify a surgical approach for MCN treatment, on the basis of Republic of Korean (Yonsei University College of Medicine, Seoul, South Korea) and Japanese (Nippon Medical School, Tokyo, Japan) bi-institutional collaboration. The present study retrospectively reviewed 55 MCNs with ovarian-type stroma using pathological re-examination. Clinicopathological features and preoperative clinical parameters were evaluated to predict malignant alterations in MCNs...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434948/granulocyte-colony-stimulating-factor-producing-mucinous-cystic-neoplasm-with-an-associated-invasive-carcinoma-of-the-pancreas
#3
Kazuhide Shimamatsu, Yoshiki Naito, Yutaro Mihara, Masamichi Nakayama, Masahiko Tanigawa, Yushi Abe, Ken Nakamura, Toshihiro Araki, Kenji Sakata, Kazunori Noguchi, Jun Akiba, Hirohisa Yano, Osamu Nakashima
The present case study documents an autopsy case of granulocyte-colony stimulating factor (G-CSF)-producing mucinous cystic neoplasm (MCN), with an associated invasive carcinoma of the pancreas. A 65-year-old woman presented to Omuta City Hospital (Omuta Japan) with a primary complaint of abdominal pain. Multiple liver nodules and a pancreatic cyst were detected upon abdominal computed tomography. Initially, liver abscess was suspected as the patient exhibited leukocytosis and elevated C-reactive protein level...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29399351/extremely-large-epithelial-ovarian-cancer-associated-with-pregnancy-a-case-report
#4
Viktoria Husz, Dorottya Bus, Gyorgy Vajda
Ovarian malignancies are rare in pregnancy; however, the incidence of abnormal adnexal masses diagnosed during pregnancy is increasing. The most common masses are ovarian cysts, and only 3-6% of those are malignant. The majority of ovarian masses are diagnosed at an early stage by routine ultrasound examinations. Malignant germ cell tumors are the most common ovarian malignancies associated with pregnancy, while the incidence of epithelial ovarian cancer is only 1:12,000-1:50,000 of pregnancies. The diagnosis and management of ovarian cancer during pregnancy remain unclear due to the rare occurrence and scant data on this condition...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29398147/-ovarian-sertoli-leydig-tumor-a-tricky-tumor
#5
Nicolas Brandone, Claude Borrione, Angélique Rome, André Maues de Paula
We report the case of a 15 years old teenage girl presenting with a primary amenorrhea and hypervirilisation symptoms. The clinical assessement found a 16cm wide heterogenous ovarian mass testosteronemia and alpha-foeto protein levels were increased. On gross exam the tumor was solid and cystic, multilocular containing serous and mucinous liquids. Microscopically, there was a sertoli cells rich solid area in which the cells had a trabecular and nested organization with Leydig cells between them and there was also a cystic area made of glandular structures lined with an intestinal muco-secreting epithelium...
February 1, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29394168/low-grade-endometrioid-stromal-sarcoma-of-the-paratestis-a-novel-report-with-molecular-confirmation-of-jazf1-suz12-translocation
#6
Abbas Agaimy, Evgeny A Moskalev, Wera Weisser, Thorsten Bach, Florian Haller, Arndt Hartmann
Tumors with Müllerian-like serous or mucinous phenotypes originating in the testis and its adnexa are rare neoplasms that have been increasingly recognized in recent years. Cystadenomas with or without ovarian-type stroma, borderline tumors, and adenocarcinomas are the main documented types. Although a handful cases of putative endometrioid adenocarcinomas have been reported, to our knowledge no case of endometrial stromal-type neoplasm has ever been reported in the literature. A 59-year-old man presented with a 2 cm left intrascrotal mass that was found on sonographic examination to arise from the epididymal tail with prominent vascularization...
February 1, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29389895/ovarian-cancers-genetic-abnormalities-tumor-heterogeneity-and-progression-clonal-evolution-and-cancer-stem-cells
#7
REVIEW
Ugo Testa, Eleonora Petrucci, Luca Pasquini, Germana Castelli, Elvira Pelosi
Four main histological subtypes of ovarian cancer exist: serous (the most frequent), endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large majority of ovarian cancers are diagnosed as high-grade serous ovarian cancers (HGS-OvCas). TP53 is the most frequently mutated gene in HGS-OvCas; about 50% of these tumors displayed defective homologous recombination due to germline and somatic BRCA mutations, epigenetic inactivation of BRCA and abnormalities of DNA repair genes; somatic copy number alterations are frequent in these tumors and some of them are associated with prognosis; defective NOTCH, RAS/MEK, PI3K and FOXM1 pathway signaling is frequent...
February 1, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29375949/biliary-mucinous-cystic-neoplasm-of-the-liver-with-ovarian-stroma-and-elevated-serum-and-cystic-fluid-cancer-antigen-19-9-levels
#8
Georgios P Fragulidis, Eirini V Pantiora, Elissaios A Kontis, Elias Primetis, Andreas Polydorou, Eleni Karvouni, George Polymeneas
Biliary mucinous cystic neoplasms of the liver are rare cystic tumors comprising less than 5% of the liver cystic neoplasms. These tumors demonstrate a female predominance and entail a risk of malignant transformation. We present a 56-year-old female patient with a multiloculated liver cystic lesion measuring 22 cm who underwent a cystectomy with en bloc resection of the liver segments II, III, and cholecystectomy. Serum cancer antigen 19.9 was 4,122.00 U/ml, supporting the diagnosis of a biliary cystic tumor...
November 20, 2017: Curēus
https://www.readbyqxmd.com/read/29374695/low-expression-of-cd44-is-an-independent-factor-of-poor-prognosis-in-ovarian-mucinous-carcinoma
#9
Hiroko Matuura, Morikazu Miyamoto, Masashi Takano, Hiroaki Soyama, Tadashi Aoyama, Tomoyuki Yoshikawa, Kento Kato, Takahiro Sakamoto, Mika Kuwahara, Kazuki Takasaki, Hiroki Ishibashi, Hideki Iwahashi, Hitoshi Tsuda, Kenichi Furuya
AIM: To determine whether CD44, which is associated with tumor growth and metastasis, is related to carcinogenesis and prognosis in ovarian mucinous carcinomas (MACs). MATERIALS AND METHODS: Tissue blocks from 71 patients with benign mucinous ovarian tumors were used in the study: 35 were from patients with borderline mucinous ovarian tumors, and 60 from patients with MACs. Immunochemical analysis was performed to evaluate the expression of CD44 and examine its association with tumorigenesis and survival...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29338553/comprehensive-clinicopathologic-and-updated-immunohistochemical-characterization-of-primary-ovarian-mucinous-carcinoma
#10
Dina Bassiouny, Nadia Ismiil, Valerie Dubé, Guangming Han, Matthew Cesari, Fang-I Lu, Elzbieta Slodkowska, Carlos Parra-Herran, Hak Fai Chiu, Magda Naeim, Nim Li, Mahmoud Khalifa, Sharon Nofech-Mozes
The distinction of primary mucinous ovarian carcinoma (PMOC) from other primaries or secondaries is essential for selecting therapeutic options and prognostication. We aimed to characterize the immunohistochemical profile of 36 PMOCs using an extended immunohistochemical panel, with clinicopathologic features and outcome. PAX8 was negative in 30 (83.3%), and SATB2 was negative in 32/35. HNF1B, AMACR, and napsin-A were detected in 33 (91.7%), 35 (97.2%), and 0 (0%), respectively. MMR proteins and ARID1A were retained in 100%; PTEN was lost in 4 (11...
January 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29298536/improvement-of-hyperandrogenism-oligo-ovulation-and-ovarian-morphology-in-a-patient-with-polycystic-ovary-syndrome-possible-role-of-ovarian-wedge-resection
#11
YuanYuan Zhang, SuiYu Luo, ZhiQuan Gong, XiaoYa Feng, ZiYi Wang, HaoHui Zhu, Yu Wang
Polycystic ovary syndrome (PCOS) is an endocrinological abnormality which typically presents as hormones disorder and/or infertility. It has received more and more attention in recent years though its pathogenesis is still unclear. Ovarian mucinous adenoma is a rarely pathological type which generates from epithelial cell of ovary. Here we present a patient with PCOS and ovarian mucinous tumor (occasionally discovered by cesarean section) receiving a complete relief after benign ovarian tumor excision. In this case, tumor excision played as a partial resection of ovary which might result in the normalized concentration level of hormones and morphology of ovary...
January 3, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29281007/safety-of-ovarian-tissue-transplantation-in-patients-with-borderline-ovarian-tumors
#12
Rossella Masciangelo, Chiara Bosisio, Jacques Donnez, Christiani A Amorim, Marie-Madeleine Dolmans
STUDY QUESTION: Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure? SUMMARY ANSWER: BOT cells were found in frozen-thawed and xenografted ovarian tissue in 1 of 11 BOT patients. WHAT IS KNOWN ALREADY: The risk of reintroducing malignant cells upon ovarian tissue transplantation has been subject of debate for many years. Reimplantation of cryopreserved ovarian tissue from leukemia patients is unsafe, while results from studies of cryopreserved ovarian tissue from other forms of cancer, such as Hodgkin's lymphoma, are reassuring...
December 21, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29250686/ovarian-strumal-carcinoid-case-report
#13
Delia Gabriela Ciobanu Apostol, Tudor Andrei BuŢureanu, Demetra Gabriela Socolov, Daniela Claudia Scripcaru, Oana LuminiŢa Rosin, Ludmila Lozneanu
Strumal carcinoid represents a rare form of ovarian teratoma, consisting of both thyroid tissue and carcinoid structures. The carcinoid component is a well-differentiated neuroendocrine tumor with excellent prognosis. Strumal carcinoid tumors are commonly found in peri-menopausal women who are not usually interested in preserving their fertility and who are thus open to radical surgical treatment. In this report, we present a 24-year-old, nulliparous patient with strumal carcinoid, confirmed by histopathology and a large panel of immunohistochemistry (IHC) markers, who wished to preserve her fertility...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29247577/ovarian-cancer-risk-aldh2-polymorphism-and-alcohol-drinking-asian-data-from-the-ovarian-cancer-association-consortium
#14
Tomotaka Ugai, Linda E Kelemen, Mika Mizuno, Jue-Sheng Ong, Penelope M Webb, Georgia Chenevix-Trench, Kristine G Wicklund, Jennifer Anne Doherty, Mary Anne Rossing, Pamela J Thompson, Lynne R Wilkens, Michael E Carney, Marc T Goodman, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Hui Cai, Xiao-Ou Shu, Yu-Tang Gao, Yong-Bing Xiang, David Van Den Berg, Malcom C Pike, Anna H Wu, Celeste Leigh Pearce, Keitaro Matsuo
The ALDH2 polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case-control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1,274 controls of Asian descent with information on recent alcohol consumption...
December 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/29242280/results-of-fertility-sparing-surgery-for-expansile-and-infiltrative-mucinous-ovarian-cancers
#15
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
BACKGROUND: No series had been reported focusing on the results of fertility-sparing surgery in stage I mucinous ovarian cancers according to histotype (infiltrative vs. expansile). Investigating such outcomes was the aim of the present study. MATERIALS AND METHODS: The present study was a retrospective analysis of patients treated conservatively with preservation of the uterus and contralateral ovary from 1976 to 2016. The pathology of the tumors was reviewed by two expert pathologists according to the 2014 World Health Organization (WHO) classification criteria...
December 14, 2017: Oncologist
https://www.readbyqxmd.com/read/29197420/ovarian-mucinous-borderline-tumor-accompanied-by-lgess-with-myxoid-change-a-case-report-and-literature-review
#16
Wen Wang, Yalin Zhuang, Feng Zhou, Lili Huang
OBJECTIVES: To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. CASE PRESENTATION: A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA19-9 levels were normal. Magnetic resonance imaging showed a 10-cm cystic mass with a 5-cm nodule in its wall, and a laparoscopy indicated a cystic mass at the left adnexa...
December 2, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29194190/an-evaluation-of-frozen-section-and-lymph-node-dissection-results-for-mucinous-ovarian-tumors
#17
Marisa R Moroney, Miriam D Post, Amber A Berning, Jeanelle Sheeder, Bradley R Corr
OBJECTIVES: Intraoperative frozen section has greater than 90% accuracy for ovarian tumors; however, mucinous histology has been shown to be associated with increased frozen section inaccuracy. Recent data demonstrate that primary ovarian mucinous carcinomas have no lymph node involvement, even when extraovarian disease is present, and therefore may not require lymph node dissection. Our primary objective is to evaluate the accuracy of identifying mucinous histology on frozen section...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29187928/hormone-receptor-expression-status-of-epithelial-ovarian-cancer-in-ibadan-south-western-nigeria
#18
Mustapha Akanji Ajani, Ayodeji Salami, Olutosin Alaba Awolude, Abideen Olayiwola Oluwasola
Introduction: Epidemiological evidence strongly suggests that steroid hormones are implicated in the pathogenesis of ovarian cancer. Estrogen receptor (ER) and Progesterone receptor (PR) are prognostic indicators for a number of epithelial tumors and may play the same role in ovarian cancers. This study aims to evaluate the expression of ER and PR in epithelial ovarian cancer (EOC) in an African population and compare it with other prognostic factors such as age, International Federation of Gynaecology and Obstetrics (FIGO) stage, grade and histological subtype...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29177806/the-long-term-survival-in-primary-retroperitoneal-mucinous-cystadenocarcinoma-a-case-report
#19
Hirotaka Tokai, Yasuhiro Nagata, Ken Taniguchi, Naomi Matsumura, Amane Kitasato, Takayuki Tokunaga, Hiroaki Takeshita, Tamotsu Kuroki, Shigeto Maeda, Masahiro Ito, Hikaru Fujioka
BACKGROUND: Primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is extremely rare, and its biological behavior, pathogenesis, optimum treatments, and prognosis remain to be elucidated. We herein report a case of PRMC with an 80-month follow-up. CASE PRESENTATION: A 29-year-old woman was diagnosed with unknown retroperitoneal tumor with benign right ovarian cyst and uterine fibroids, and she underwent laparotomy. The tumor was completely resected with a subsequent histopathological diagnosis of primary retroperitoneal mucinous cystadenocarcinoma (PRMC)...
November 25, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29174556/risk-of-borderline-ovarian-tumors-among-women-with-benign-ovarian-tumors-a-cohort-study
#20
Sonia Guleria, Allan Jensen, Susanne K Kjær
OBJECTIVE: A growing number of studies suggest that some ovarian cancers can arise from benign and borderline ovarian tumors. However, studies on the association between benign and borderline ovarian tumors are lacking. We studied the overall- and histotype-specific risk of borderline ovarian tumors among women with a benign ovarian tumor. METHODS: This nationwide cohort study included all Danish women diagnosed with a benign ovarian tumor (n=139,466) during 1978-2012...
November 23, 2017: Gynecologic Oncology
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