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mucinous ovarian tumor

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https://www.readbyqxmd.com/read/29049607/dose-response-association-of-cd8-tumor-infiltrating-lymphocytes-and-survival-time-in-high-grade-serous-ovarian-cancer
#1
Ellen L Goode, Matthew S Block, Kimberly R Kalli, Robert A Vierkant, Wenqian Chen, Zachary C Fogarty, Aleksandra Gentry-Maharaj, Aleksandra Toloczko, Alexander Hein, Aliecia L Bouligny, Allan Jensen, Ana Osorio, Andreas D Hartkopf, Andy Ryan, Anita Chudecka-Glaz, Anthony M Magliocco, Arndt Hartmann, Audrey Y Jung, Bo Gao, Brenda Y Hernandez, Brooke L Fridley, Bryan M McCauley, Catherine J Kennedy, Chen Wang, Chloe Karpinskyj, Christiani B de Sousa, Daniel G Tiezzi, David L Wachter, Esther Herpel, Florin Andrei Taran, Francesmary Modugno, Gregg Nelson, Jan Lubinski, Janusz Menkiszak, Jennifer Alsop, Jenny Lester, Jesús García-Donas, Jill Nation, Jillian Hung, José Palacios, Joseph H Rothstein, Joseph L Kelley, Jurandyr M de Andrade, Luis Robles-Díaz, Maria P Intermaggio, Martin Widschwendter, Matthias W Beckmann, Matthias Ruebner, Mercedes Jimenez-Linan, Naveena Singh, Oleg Oszurek, Paul R Harnett, Peter F Rambau, Peter Sinn, Philipp Wagner, Prafull Ghatage, Raghwa Sharma, Robert P Edwards, Roberta B Ness, Sandra Orsulic, Sara Y Brucker, Sharon E Johnatty, Teri A Longacre, Ursula Eilber, Valerie McGuire, Weiva Sieh, Yanina Natanzon, Zheng Li, Alice S Whittemore, Anna deFazio, Annette Staebler, Beth Y Karlan, Blake Gilks, David D Bowtell, Estrid Høgdall, Francisco J Candido Dos Reis, Helen Steed, Ian G Campbell, Jacek Gronwald, Javier Benítez, Jennifer M Koziak, Jenny Chang-Claude, Kirsten B Moysich, Linda E Kelemen, Linda S Cook, Marc T Goodman, María José García, Peter A Fasching, Stefan Kommoss, Suha Deen, Susanne K Kjaer, Usha Menon, James D Brenton, Paul D P Pharoah, Georgia Chenevix-Trench, David G Huntsman, Stacey J Winham, Martin Köbel, Susan J Ramus
Importance: Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns of CD8+ TILs by histotype and in relation to other clinical factors. Objective: To define the prognostic role of CD8+ TILs in epithelial ovarian cancer. Design, Setting, and Participants: This was a multicenter observational, prospective survival cohort study of the Ovarian Tumor Tissue Analysis Consortium...
October 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29045292/ovarian-metastases-of-breast-cancers-with-signet-ring-cells-a-report-of-17-cases-including-14-krukenberg-tumors
#2
Jennifer A Bennett, Robert H Young, Ai-Ying Chuang, Melinda F Lerwill
Krukenberg tumor, defined as metastatic adenocarcinoma to the ovary containing at least 10% signet ring cells, usually arises from the stomach but can also originate from other sites. We reviewed 17 metastatic breast carcinomas to the ovary with signet ring cells to potentially identify features indicative of mammary origin as opposed to other possible primary sites. The patients ranged from 41 to 76 (mean, 53.6) yr. Fourteen had a prior history of invasive breast carcinoma (invasive ductal carcinoma, 4; invasive lobular carcinoma, 3; adenocarcinoma not otherwise specified, 3; carcinoma with ductal and lobular features, 2; and unspecified carcinoma, 2) and metastases were identified 2 to 284 (mean, 79) mo after the original diagnosis...
October 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29039611/altered-expression-of-different-galnac%C3%A2-transferases-is-associated-with-disease-progression-and-poor-prognosis-in-women-with-high-grade-serous-ovarian-cancer
#3
Razan Sheta, Magdalena Bachvarova, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Alexandra Sebastianelli, Ion Popa, Dimcho Bachvarov
Protein glycosylation perturbations are implicated in a variety of diseases, including cancer. Aberrant glycosylation in cancer is frequently attributed to altered expression of polypeptide GalNAc transferases (GalNAc‑Ts) - enzymes initiating mucin-type O-glycosylation. A previous study from our group demonstrated that one member of this family (GALNT3) is overexpressed in epithelial ovarian cancer (EOC), and GALNT3 expression correlated with shorter progression-free survival (PFS) in EOC patients with advanced disease...
October 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29028099/the-diagnostic-value-of-determination-of-serum-golph3-associated-with-ca125-ca19-9-in-patients-with-ovarian-cancer
#4
H-Y Fan, D-M Duan, Y-F Liu
OBJECTIVE: To evaluate the value of three tumor markers serum Golgi phosphoprotein-3 (GOLPH3), cancer antigen 125 (CA125) and cancer antigen 19-9 (CA19.9) in the diagnosis and postoperative evaluation of ovarian cancer by detecting these three markers. PATIENTS AND METHODS: A total of 187 patients were studied and included in the ovarian cancer group, benign pelvic mass group, and the normal control group. The levels of serum Golgi phosphoprotein-3 (GOLPH3), cancer antigen 125 (CA125) and cancer antigen 199 (CA19...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29022007/is-uterine-preservation-combined-with-bilateral-salpingo-oophorectomy-to-promote-subsequent-fertility-safe-in-infiltrative-mucinous-ovarian-cancer
#5
Sebastien Gouy, Marine Saidani, Amandine Maulard, Matthieu Faron, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
According to the latest World Health Organization classification (2014), mucinous ovarian cancers should be classified histologically as being either expansile or infiltrative. Compared to other epithelial cancers, both of these mucinous patterns are diagnosed, in the main, at an early stage, although they can affect relatively young patients. The infiltrative subtype is characterized by a morphologically and clinically more aggressive disease versus the expansile form. Consequently, even in young patients who would prefer fertility sparing management, the removal of both ovaries (even for a unilateral tumor) remains a common recommendation...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28992761/kras-mutation-testing-in-borderline-ovarian-tumors-and-low-grade-ovarian-carcinomas-with-a-rapid-fully-integrated-molecular-diagnostic-system
#6
Pawel Sadlecki, Paulina Antosik, Dariusz Grzanka, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
Epithelial ovarian neoplasms are a heterogeneous group of tumors, including various malignancies with distinct clinicopathologic and molecular features. Mutations in BRAF and KRAS genes are the most frequent genetic aberrations found in low-grade serous ovarian carcinomas and serous and mucinous borderline tumors. Implementation of targeted therapeutic strategies requires access to highly specific and highly sensitive diagnostic tests for rapid determination of mutation status. One candidate for such test is fully integrated, real-time polymerase chain reaction-based Idylla™ system for quick and simple detection of KRAS mutations in formaldehyde fixed-paraffin embedded tumor samples...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28989924/epithelial-ovarian-tumors-in-a-premenarchal-girl-a-rare-case-report
#7
Pushpanjali Ojha, Jitendra Singh Nigam, Archana Hemant Deshpande, Chitrawati Bal Gargade
Ovarian tumors are relatively uncommon in paediatric age group and mostly occur in the period after menarche and are extremely rare prior to menarche. However, in children and adolescent, the epithelial ovarian tumors account approximately 10% to 28% of all ovarian tumors. In the present case, the patient was presented with abdominal pain for 1 day and no mass was felt on physical examination. Contrast-enhance computed tomography abdomen and pelvis showed a left ovarian cystic mass measuring 7.3×5.1 cm in size and unilateral oophorectomy was done...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28984773/ovarian-torsion-of-mixed-epithelial-tumor-misdiagnosed-as-a-malignancy-in-postmenopausal-woman-a-case-report
#8
Hyeji Jeon, Aeli Ryu, Hui-Gyeong Seo, Si-Hyong Jang
RATIONALE: Adnexal torsion is 1 of the most common emergency gynecological disease. It is more often diagnosed in reproductive age, but rarely in postmenopausal women. The clinical symptoms of adnexal torsion are nonspecific in postmenopausal women. Epithelial ovarian tumors are common in adults, and the risk of malignancy increases with age, especially after menopause. So, it is difficult to diagnose adnexal torsion precisely compared with reproductive women, and most cases of adnexal torsion with postmenopausal women are diagnosed as a malignancy preoperatively...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28983627/systematic-module-approach-identifies-altered-genes-and-pathways-in-four-types-of-ovarian-cancer
#9
Jing Liu, Hui-Ling Wang, Feng-Mei Ma, Hong-Ping Guo, Ning-Ning Fang, Shan-Shan Wang, Xin-Hong Li
The present study aimed to identify altered genes and pathways associated with four histotypes of ovarian cancer, according to the systematic tracking of dysregulated modules of reweighted protein‑protein interaction (PPI) networks. Firstly, the PPI network and gene expression data were initially integrated to infer and reweight normal ovarian and four types of ovarian cancer (endometrioid, serous, mucinous and clear cell carcinoma) PPI networks based on Spearman's correlation coefficient. Secondly, modules in the PPI network were mined using a clique‑merging algorithm and the differential modules were identified through maximum weight bipartite matching...
September 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28982877/the-impact-of-surgical-staging-on-the-prognosis-of-mucinous-borderline-tumors-of-the-ovaries-a-multicenter-study
#10
MULTICENTER STUDY
Kemal Gungorduk, Osman Asicioglu, Elena Ioana Braicu, Jumana Almuheimid, Sevki Goksun Gokulu, Nilufer Cetinkaya, Tayfun Gungor, Gonca Pakay, Elcin Uzmez Telli, Zeliha Firat Cuylan, Tayfun Toptas, Ahmet Bilgi, Ramazan Ozyurt, Elif Agacayak, Aykut Ozdemir, Nuri Yildirim, Salih Taskin, Tufan Oge, Onur Erol, Levent Akman, Anil Turan, Mehmet Sait Icen, Taylan Senol, Ozlem Irak Ovali, Burcu Yucesoy, Ozgu Gungorduk, Osman Temizkan, Muzaffer Sanci, Tayup Simsek, Mehmet Mutlu Meydanli, Mehmet Harma, Levent Yasar, Aysel Derbent Uysal, Ates Karateke, Firat Ortac, Sabit Sinan Ozalp, Jalid Sehouli, Mustafa Zelal Muallem
BACKGROUND/AIM: The purpose of this study was to prove the effect of complete surgical staging of patients with mucinous borderline ovarian tumors (mBOTs) especially appendectomy on progression-free survival (PFS) and overall survival (OS). PATIENTS AND METHODS: The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28976119/krukenberg-carcinoma-metastasized-from-stomach-resembling-mucinous-cystadenocarcinoma-of-the-ovary
#11
Melike Doğanay, Hasan Onur Topçu, Mahmut Kuntay Kokanalı, Ali I Rfan Güzel, Aslı Oskovi, Serap Akbay, Sabri Cavkaytar
The ovaries are common site of metastasis in a variety of primary neoplasms. Multiple tumors such as breast, lung, and pancreas have been reported to metastasize to the ovary, however; the colon and stomach are the most common primary cancer sites that of ovarian metastasis. An ovarian mass mostly originates from its self-tissue, but sometimes it can be a metastasis of a gastrointestinal system tumor. Such cases are often misdiagnosed as primary ovarian cancers. A 42-year-old woman was admitted to our hospital with pelvic pain...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28971140/staging-surgery-in-early-stage-ovarian-mucinous-tumors-according-to-expansile-and-infiltrative-types
#12
Sebastien Gouy, Marine Saidani, Amandine Maulard, Matthieu Faron, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
The aim of this study is to determine the value of surgical staging for the two histologic types (expansile or infiltrative) of apparent stage I mucinous ovarian carcinoma. We retrospectively analyzed patients treated from 1976 and 2016 for apparent macroscopic stage I ovarian mucinous carcinoma. Extra-ovarian disease and tumors that metastasized to the ovaries were excluded. Two expert pathologists performed pathologic reviews of tumor data, according to 2014 WHO classification criteria. Tumors were typed as expansile or infiltrative and clinical and histologic characteristics were studied...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28968158/satb2-as-an-immunohistochemical-marker-for-colorectal-adenocarcinoma-a-concise-review-of-benefits-and-pitfalls
#13
Kyra B Berg, David F Schaeffer
SATB2 is part of the family of matrix attachment region-binding transcription factors, and has developmental roles in craniofacial, neural, and osteoblastic differentiation. Recently, SATB2 has been shown to be highly expressed in the epithelium of the lower gastrointestinal tract, with a relatively narrow expression profile in malignancies, including colorectal/appendiceal adenocarcinomas, tumors of osteoblastic differentiation, and renal/urothelial carcinomas. SATB2 has gained interest as a relatively specific marker of colorectal differentiation, with potential applications including determining origin of adenocarcinomas of unknown primary and distinguishing primary ovarian mucinous adenocarcinomas from colorectal metastases...
October 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28928856/the-putative-role-of-tp53-alterations-and-p53-expression-in-borderline-ovarian-tumors-correlation-with-clinicopathological-features-and-prognosis-a-mini-review
#14
REVIEW
Andrzej Semczuk, Marek Gogacz, Anna Semczuk-Sikora, Maciej Jóźwik, Tomasz Rechberger
Borderline ovarian tumors (BOTs) represent an independent group among ovarian malignancies, being diagnosed at clinical stage earlier than invasive ovarian carcinomas (OCs) and characterized by a rather favorable outcome after careful surgical management. Data published worldwide showed a substantial discordance of p53 expression in BOTs. The purpose of this work was to present the current status of knowledge on the significance of TP53 gene and p53 protein product alterations in BOTs. In general, higher p53 expression patterns were reported for ovarian malignancies compared to BOTs...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28913150/features-of-ovarian-brenner-tumors-experience-of-a-single-tertiary-center
#15
Batuhan Turgay, Kazibe Koyuncu, Salih Taşkın, Uğur Fırat Ortaç
OBJECTIVE: Brenner tumors are rare neoplasms of the ovary. The aim of this study was to investigate the clinical features of Brenner tumors. MATERIALS AND METHODS: The clinical features of 22 patients who were treated in Ankara University Faculty of Medicine Obstetrics and Gynecology Department between 2005 and 2015 were evaluated retrospectively from hospital medical records. RESULTS: The patients were aged 34 to 79 years at the time of diagnosis and the mean age was 55...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28899828/borderline-ovarian-tumor-in-the-pediatric-and-adolescent-population-a-case-series-and-literature-review
#16
Krista J Childress, Ninad Mohan Patil, Jodi A Muscal, Jennifer E Dietrich, Rajkumar Venkatramani
STUDY OBJECTIVE: To determine the diagnosis, management, and outcome for children and adolescents with borderline ovarian tumor (BOT), To provide a review of the literature on BOT in children and adolescents. DESIGN: A retrospective cohort study of females under age 21 diagnosed with BOT between January 2001 and May 2016. SETTING: Texas Children's Hospital, Houston, Texas PARTICIPANTS: Fourteen patients (ages 12 to 18) diagnosed with BOT. MAIN OUTCOME MEASURES: Clinical presentation, pre-operative characteristics, surgical technique, cancer stage, histology, treatment, recurrence...
September 9, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28871344/tubal-ligation-and-ovarian-cancer-risk-in-african-american-women
#17
Chrissy McNamara, Sarah E Abbott, Elisa V Bandera, Bo Qin, Lauren C Peres, Fabian Camacho, Patricia G Moorman, Anthony J Alberg, Jill S Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Edward S Peters, Ann G Schwartz, Joellen M Schildkraut, Paul Terry
PURPOSE: Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 invasive ovarian cancer cases and 742 controls of AA descent recruited from the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. METHODS: Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for potentially confounding factors...
September 4, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28852190/mutational-heterogeneity-in-non-serous-ovarian-cancers
#18
Jamie K Teer, Sean Yoder, Anxhela Gjyshi, Santo V Nicosia, Chaomei Zhang, Alvaro N A Monteiro
Epithelial ovarian cancer is a leading cause of death in gynecological cancers. While several systematic studies have revealed the mutation landscape of serous epithelial ovarian cancer, other non-serous subtypes of the disease have not been explored as extensively. Here we conduct exome sequencing of nine non-serous epithelial ovarian tumors (six endometrioid and three mucinous) and their corresponding normal DNA as well as a tumor-only granulosa cell sample. We integrated the exome data with targeted gene sequencing for 1,321 genes selected for their involvement in cancer from additional 28 non-serous ovarian tumors and compared our results to TCGA ovarian serous cystadenocarcinoma and uterine corpus endometrial carcinomas...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28835081/-the-clinicopathological-features-and-risk-factors-of-recurrence-in-patients-with-mucinous-borderline-ovarian-tumors
#19
L Sun, Y Song, N Li, G W Yuan, Y C Sun, N Li, S K Ma, X Zhang, L Y Wu
Objective: To investigate the clinicopathological features and risk factors in patients with mucinous borderline ovarian tumors (MBOT). Methods: From 1999 to 2006, 66 MBOT patients in our hospital with more than ten-year follow-up were enrolled retrospectively. They were re-classified according to the literature. The clinicopathological features of different subgroups, including age, preoperative serum tumor markers, surgical methods, pathological features, surgical pathology staging, as well as the risk factors of recurrence and survival were analyzed...
August 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28804560/mechanisms-of-mir-145-regulating-invasion-and-metastasis-of-ovarian-carcinoma
#20
Ling Wang, Xiaotong Wu, Bowei Wang, Qiang Wang, Liying Han
MicroRNA-145 (miR-145) can regulate tumor cell invasion, metastasis, apoptosis, proliferation and stem cell differentiation. However, the molecular mechanisms of miR-145 used to regulate ovarian invasion and metastasis remain to be determined. In this study, Transwell cell migration and wound healing assays were used to detect the effects of miR-145 upregulation on ovarian carcinoma cell invasion and metastasis, respectively. The MUC1 expression vector, together with quantitative real-time PCR and Western blotting, was used to investigate the effects of miR-145 on E-cadherin (E-cad)-induced cell invasion and the related molecular mechanisms...
2017: American Journal of Translational Research
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