Zhengyu Jiang, Quin T Waterbury, Ermanno Malagola, Na Fu, Woosook Kim, Yosuke Ochiai, Feijing Wu, Chandan Guha, Carrie J Shawber, Kelley S Yan, Timothy C Wang
BACKGROUND & AIMS: The intestinal epithelium functions both in nutrient absorption and as a barrier, separating the luminal contents from a network of vascular, fibroblastic, and immune cells underneath. Following injury to the intestine, multiple cell populations cooperate to drive regeneration of the mucosal barrier, including lymphatic endothelial cells (LECs). A population of granulocytic immature myeloid cells (IMCs), marked by histidine decarboxylase (Hdc), participate in regeneration of multiple organs such as the colon and central nervous system, but their contribution to intestinal regeneration was unknown...
October 26, 2023: Cellular and Molecular Gastroenterology and Hepatology