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https://www.readbyqxmd.com/read/29448512/thymosin-%C3%AE-4-reduces-h%C3%A2-o%C3%A2-induced-oxidative-stress-in-mc3t3-e1-cells-on-titanium-surface
#1
Baik-Dong Choi, Do-Seon Lim, Seung-Yeon Lee, Tae-Hee Nho, Soon-Jeong Jeong, Yeong-Mu Ko, Sung-Nam Gang, Young-Joon Kim, Xing-Hui Piao, Moon-Jin Jeong
Thymosin β4 (Tβ4) is known to inhibit an inflammatory response and to increase the survival of osteoblasts on titanium (Ti) surfaces. Ti is the most widely used graft material in dentistry; however, an inflammatory response induced following implant placement results in the generation of reactive oxygen species (ROS). The oxidative stress from the production of ROS such as nitric oxide (NO) and hydrogen peroxide (H2O2) can damage surrounding cells, resulting in implant failure by decreasing cell viability...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447132/role-of-gpcr-mu-opioid-receptor-tyrosine-kinase-epidermal-growth-factor-crosstalk-in-opioid-induced-hyperalgesic-priming-type-ii
#2
Dionéia Araldi, Luiz F Ferrari, Jon D Levine
Repeated stimulation of mu-opioid receptors (MORs), by an MOR-selective agonist DAMGO induces type II priming, a form of nociceptor neuroplasticity, which has 2 components: opioid-induced hyperalgesia (OIH) and prolongation of prostaglandin-E2 (PGE2)-induced hyperalgesia. We report that intrathecal antisense knockdown of the MOR in nociceptors, prevented the induction of both components of type II priming. Type II priming was also eliminated by SSP-saporin, which destroys the peptidergic class of nociceptors...
January 11, 2018: Pain
https://www.readbyqxmd.com/read/29444936/aspirin-alone-and-combined-with-a-statin-suppresses-eicosanoid-formation-in-human-colon-tissue
#3
Heike Gottschall, Christoph Schmoecker, Dirk Hartmann, Nadine Rohwer, Katharina Rund, Laura Kutzner, Fabian Nolte, Annika I Ostermann, Nils Helge Schebb, Karsten H Weylandt
Eicosanoids, including prostaglandins and thromboxanes, are broadly bioactive lipid mediators and increase colon tumorigenesis possibly through chronic inflammatory mechanisms. Epidemiological and experimental data suggest that acetylsalicylic acid (ASA) helps prevent colorectal cancer (CRC), possibly through cyclooxygenase (COX)-mediated suppression of eicosanoid - particularly prostaglandin E2 (PGE2) - formation. Recent studies suggest that statins prevent CRC and improve survival after diagnosis. We identified patients on ASA and/or statin treatment undergoing routine colonoscopy and measured eicosanoid levels in colonic mucosa with targeted metabolomics technology (LC-MS/MS)...
February 14, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29442202/anti-inflammatory-effect-of-oligostilbenoids-from-vitis-heyneana-in-lps-stimulated-raw-264-7-macrophages-via-suppressing-the-nf-%C3%AE%C2%BAb-activation
#4
Do Thi Ha, Phung Thanh Long, Tran Thi Hien, Dao Trong Tuan, Nguyen Thi Thuy An, Nguyen Minh Khoi, Ha Van Oanh, Tran Manh Hung
BACKGROUND: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. RESULTS: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10)...
February 13, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29442025/sinomenine-inhibits-the-inflammatory-responses-of-human-fibroblast-like-synoviocytes-via-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway-in-rheumatoid-arthritis
#5
Ru-Bing Yao, Zhi-Ming Zhao, Ling-Jie Zhao, Hui Cai
Rheumatoid arthritis (RA) is a systemic autoimmune disorder mainly characterized by inflammation of the synovial tissue that can lead to destruction of bone and cartilage. Sinomenine is an alkaloid extracted from the stem of the Chinese medicinal plant Sinomenium acutum. It has been reported that sinomenine has immunosuppressive and anti-inflammatory properties. However, the molecular mechanism underlying the effect of sinominine on IL-1β-induced human RA fibroblast-like synoviocytes (RAFLS) is poorly understood...
June 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440395/fatty-acid-binding-protein-5-controls-microsomal-prostaglandin-e-synthase-1-mpges-1-induction-during-inflammation
#6
Diane Bogdan, Jerome Falcone, Martha P Kanjiya, Sang Hoon Park, Gregory Carbonetti, Keith Studholme, Maria Gomez, Yong Lu, Matthew W Elmes, Norbert Smietalo, Su Yan, Iwao Ojima, Michelino Puopolo, Martin Kaczocha
Fatty acid binding proteins (FABPs) are intracellular lipid carriers that regulate inflammation, and pharmacological inhibition of FABP5 reduces inflammation and pain. The mechanism(s) underlying the anti-inflammatory effects associated with FABP5 inhibition are poorly understood. Herein, we identify a novel mechanism through which FABP5 modulates inflammation. In mice, intraplantar injection of carrageenan induces acute inflammation that is accompanied by edema, enhanced pain sensitivity, and elevations in pro-inflammatory cytokines and prostaglandin E2 (PGE2)...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29436586/amelioration-of-inflammatory-responses-by-socheongryong-tang-a-traditional-herbal-medicine-in-raw-264-7%C3%A2-cells-and-rats
#7
Sang Mi Park, Tae Hoon Lee, Rongjie Zhao, Youn Sook Kim, Ji Yun Jung, Chung A Park, Kyung Hwan Jegal, Sae Kwang Ku, Jae Kwang Kim, Chul Won Lee, Young Woo Kim, Il Je Cho, Won G An, Sang Chan Kim
Socheongryong-Tang (SCRT) is a natural medicine prescription that has been mainly used in East Asia for the treatment of inflammatory disorders, including asthma and allergic rhinitis. The present study evaluated the anti-inflammatory effects of SCRT on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in a rat model of carrageenan (CA)-induced paw edema. Levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in the culture supernatant were quantified and nitric oxide (NO) production was monitored...
February 6, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29434748/mapk-pathway-mediates-the-anti-oxidative-effect-of-chicoric-acid-against-cerebral-ischemia-reperfusion-injury-in-vivo
#8
Linwei Jia, Yonghan Chen, Yao-Hui Tian, Gang Zhang
The aim of the present study was to investigate the protective effect of chicoric acid on oxidative stress and inflammation in rats with cerebral ischemia-reperfusion injury. A cerebral ischemia-reperfusion injury rat model was created via transient middle cerebral artery occlusion (MCAO) and rats were treated with various doses of chicoric acid (0, 1, 10 and 100 mg/kg). Neurological deficits and infarct volume were used to estimate the protective effects of chicoric acid treatment. Levels of reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, nitric oxide (NO) and prostaglandin E2 (PGE2) were assessed...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29429633/nk-cells-stimulate-recruitment-of-cdc1-into-the-tumor-microenvironment-promoting-cancer-immune-control
#9
Jan P Böttcher, Eduardo Bonavita, Probir Chakravarty, Hanna Blees, Mar Cabeza-Cabrerizo, Stefano Sammicheli, Neil C Rogers, Erik Sahai, Santiago Zelenay, Caetano Reis E Sousa
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy. Here, we show that cDC1 accumulation in mouse tumors often depends on natural killer (NK) cells that produce the cDC1 chemoattractants CCL5 and XCL1. Similarly, in human cancers, intratumoral CCL5, XCL1, and XCL2 transcripts closely correlate with gene signatures of both NK cells and cDC1 and are associated with increased overall patient survival...
February 6, 2018: Cell
https://www.readbyqxmd.com/read/29428619/effect-of-dietary-n-3-polyunsaturated-fatty-acid-rich-fish-oil-on-the-endometrial-prostaglandin-production-in-the-doe-capra-hircus
#10
Ravjibhai K Chaudhari, Ajit Singh Mahla, Amit Kumar Singh, Sanjay Kumar Singh, Abhijit M Pawde, G V P P S Ravi Kumar, GyanendraSingh, Mihir Sarkar, Harendra Kumar, Krishnaswamy Narayanan
Recently, we showed that dietary supplementation of n-3 PUFA rich fish oil (FO) decreased the metabolites of serum prostaglandin (PG) F 2α and E 2 during the window of pregnancy recognition in the doe. In this study, we investigated its effect on the changes on endometrial PG production in vitro. Cycling does (n = 12) of Rohilkhand region were divided into two equal groups and fed a concentrate diet supplemented with either FO containing 26% n-3 PUFA (TRT; n = 6) or palm oil (CON; n = 6) @ 0.6 mL/kg body weight for 57 days...
February 8, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29428221/the-inflammatory-microenvironment-that-promotes-gastrointestinal-cancer-development-and-invasion
#11
REVIEW
Kanae Echizen, Hiroko Oshima, Mizuho Nakayama, Masanobu Oshima
Accumulating evidence has indicated that the inflammatory response is important for tumor promotion. However, the mechanisms underlying the induction of the inflammatory response in cancer tissues and how it promotes tumorigenesis remain poorly understood. We constructed several mouse models that develop inflammation-associated gastric and intestinal tumors and examined the in vivo mechanisms of tumorigenesis. Of note, the activation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway and Toll-like receptor (TLR)/MyD88 signaling cooperatively induced the generation of an inflammatory microenvironment, which is required for early-stage tumorigenesis...
February 5, 2018: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29427163/anti-inflammatory-effects-of-hypophyllanthin-and-niranthin-through-downregulation-of-nf-%C3%AE%C2%BAb-mapks-pi3k-akt-signaling-pathways
#12
Hemavathy Harikrishnan, Ibrahim Jantan, Md Areeful Haque, Endang Kumolosasi
Hypophyllanthin (HYP) and niranthin (NIR) are major lignans in Phyllanthus spp. and have been shown to possess strong anti-inflammatory activity. In this study, we investigated the anti-inflammatory effects and the underlying molecular mechanisms of HYP and NIR in in vitro cellular model of LPS-induced U937 macrophages. The effects of HYP and NIR on the production of prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) were measured by using ELISA, Western blot, and qRT-PCR...
February 9, 2018: Inflammation
https://www.readbyqxmd.com/read/29426013/celecoxib-mediated-reduction-of-prostanoid-release-in-hoffa-s-fat-pad-from-donors-with-cartilage-pathology-results-in-an-attenuated-inflammatory-phenotype
#13
Ufuk Tan Timur, Marjolein M J Caron, Yvonne M Bastiaansen-Jenniskens, Tim J M Welting, L W van Rhijn, Gerjo J V M van Osch, Pieter J Emans
OBJECTIVE: The Hoffa's fat pad (HFP) is an intra-articular adipose tissue which is situated under and behind the patella. It contains immune cells next to adipocytes and secretes inflammatory factors during osteoarthritis (OA). In this study, we compared the release profile of prostanoids, which are involved in inflammation, of HFP from OA patients versus patients with a focal cartilage defect without evidence for OA on MRI and investigated the prostanoid modulatory anti-inflammatory action of celecoxib on HFP...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29425943/chlorinated-insecticides-toxaphene-and-endrin-affect-oxytocin-testosterone-oestradiol-and-prostaglandin-secretion-from-ovarian-and-uterine-cells-as-well-as-myometrial-contractions-in-cow-in%C3%A2-vitro
#14
Michael Hubert Wrobel, Jaroslaw Mlynarczuk
We examined the direct effects of toxaphene and endrin, chlorinated insecticides that are widespread in the environment, on myometrial contractions and on the secretion of hormones involved in regulating these contractions. Granulosa, luteal, endometrial and myometrial cells, and myometrial strips from non-pregnant cows were incubated with both insecticides at environmentally relevant doses. Toxaphene inhibited and endrin stimulated the secretion of testosterone and oestradiol from granulosa cells. Toxaphene also inhibited and endrin stimulated the expression of the mRNA encoding the precursor of oxytocin (OT), as well OT secretion in luteal cell cultures...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29425935/molecular-dynamics-simulation-studies-suggests-unconventional-roles-of-non-secretary-laccases-from-enteropathogenic-gut-bacteria-and-cryptococcus-neoformans-serotype-d
#15
Krishna Kant Sharma, Deepti Singh, Surender Rawat
Laccase in Cryptococcus neoformans is covalently linked to the carbohydrate moiety of the cell wall, which allows it to get access to the different substrates for catalyzing their oxidation and therefore plays a vital role in the virulence. The laccase gene (3.0 kb) from C. neoformans serotype D was amplified, cloned and sequenced for protein modeling, docking and simulation studies. The three dimensional homology models of laccase protein from C. neoformans and other pathogenic gut bacteria were docked with selected biomolecules like prostaglandins (PG), membrane phospholipids, neurotransmitters (serotonin) using GOLD software...
February 3, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29425800/influence-of-the-selective-cox-2-inhibitor-celecoxib-on-sex-differences-in-blood-pressure-and-albuminuria-in-spontaneously-hypertensive-rats
#16
Ahmed A Elmarakby, Mohamed Katary, Jennifer S Pollock, Jennifer C Sullivan
We previously reported that female spontaneously hypertensive rats (SHR) have greater cyclooxygenase-2 (COX-2) expression in the renal medulla and enhanced urinary excretion of prostaglandin (PG) E2 (PGE2) metabolites compared to male SHR. Based on the role of COX-2-derived prostanoids in the regulation of cardiovascular health, the aim of the current study was to test the hypothesis that blood pressure (BP) in female SHR is more sensitive to COX-2 inhibition than in males. Seven week old male and female SHR were implanted with telemetry transmitters for continuous BP recording...
February 6, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29425654/anti-inflammatory-and-anti-arthritic-effects-of-the-ethanolic-extract-of-aralia-continentalis-kitag-in-il-1%C3%AE-stimulated-human-fibroblast-like-synoviocytes-and-rodent-models-of-polyarthritis-and-nociception
#17
Riwon Hong, BongJun Sur, Mijung Yeom, Bombi Lee, Kyoung Soo Kim, Joyce P Rodriguez, Sanghyun Lee, Ki Sung Kang, Chang-Ki Huh, Sang Cheon Lee, Dae-Hyun Hahm
BACKGROUND: Blocking the formation and invasive growth of pannus and its secretion of inflammatory cytokines and MMPs is important for treating rheumatoid arthritis. HYPOTHESIS/PURPOSE: Anti-arthritic activity of Aralia continentalis Kitag., an oriental herbal medicine, and the underlying mechanisms involved were investigated. STUDY DESIGN: Anti-inflammatory and anti-nocicpetive activities of the ethanolic extract (50% v/v) of Aralia continentalis Kitag...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29423878/ginger-rhizome-enhances-the-anti-inflammatory-and-anti-nociceptive-effects-of-paracetamol-in-an-experimental-mouse-model-of-fibromyalgia
#18
Sergio Montserrat-de la Paz, Maria Dolores Garcia-Gimenez, Ana Maria Quilez, Rocio De la Puerta, Angeles Fernandez-Arche
BACKGROUND: The dried rhizome of ginger has been widely used for more than 2500 years in folk medicine for the treatment of various diseases that involve inflammation or are caused by oxidative stress. AIMS: This study was designed to compare the anti-nociceptive and anti-inflammatory effect of dried powdered ginger rhizome (GR) and paracetamol (APAP) on an experimental mouse model of fibromyalgia syndrome (FMS) induced by intermittent cold stress (ICS). METHODS: Forty-eight female C57BL/6 J mice were used for the experiments...
February 8, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29416671/prostaglandin-receptor-ep3-regulates-cell-proliferation-and-migration-with-impact-on-survival-of-endometrial-cancer-patients
#19
Junyan Zhu, Fabian Trillsch, Doris Mayr, Christina Kuhn, Martina Rahmeh, Simone Hofmann, Marianne Vogel, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt
Background: Prostaglandin E2 (PGE2) receptor 3 (EP3) regulates tumor cell proliferation, migration, and invasion in numerous cancers. The role of EP3 as a prognostic biomarker in endometrial cancer remains unclear. The primary aim of this study was to analyze the prognostic significance of EP3 expression in endometrial cancer. Methods: We analyzed the EP3 expression of 140 endometrial carcinoma patients by immunohistochemistry. RL95-2 endometrial cancer cell line was chosen from four endometrial cancer cell lines (RL95-2, Ishikawa, HEC-1-A, and HEC-1-B) according to EP3 expression level...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415969/osteoblastic-differentiating-potential-of-dental-pulp-stem-cells-in-vitro-cultured-on-a-chemically-modified-microrough-titanium-surface
#20
Marianna De Colli, Milena Radunovic, Vincenzo L Zizzari, Viviana di Giacomo, Chiara Di Nisio, Adriano Piattelli, José L Calvo Guirado, Barbara Zavan, Amelia Cataldi, Susi Zara
Titanium surface modification is critical for dental implant success. Our aim was to determine surfaces influence on dental pulp stem cells (DPSCs) viability and differentiation. Implants were divided into sandblasted/acid-etched (control) and sandblasted/acid-etched coated with calcium and magnesium ions (CaMg), supplied as composite, (test). Proliferation was evaluated by MTT, differentiation checking osteoblastic gene expression, PGE2 secretion and matrix formation, inflammation by Interleukin 6 (IL-6) detection...
February 8, 2018: Dental Materials Journal
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