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Erectile dysfunction and diabetes

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https://www.readbyqxmd.com/read/28212639/erectile-dysfunction-and-exposure-to-ambient-air-pollution-in-a-nationally-representative-cohort-of-older-men
#1
Lindsay A Tallon, Justin Manjourides, Vivian C Pun, Murray A Mittleman, Marianthi-Anna Kioumourtzoglou, Brent Coull, Helen Suh
BACKGROUND: Little is known about the association between air pollution and erectile dysfunction (ED), a disorder occurring in 64% of men over the age of 70, and to date, no studies have been published. To address this significant knowledge gap, we explored the relationship between ED and air pollution in a group of older men who were part of the National Social Life, Health, and Aging Project (NSHAP), a nationally representative cohort study of older Americans. METHODS: We obtained incident ED status and participant data for 412 men (age 57-85)...
February 17, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28208875/erectile-dysfunction-and-low-sex-drive-in-men-with-type-2-dm-the-potential-role-of-diabetic-pharmacotherapy
#2
Hayder M Al-Kuraishy, Ali I Al-Gareeb
INTRODUCTION: Diabetic men with erectile dysfunction have not been widely studied. They have low testosterone levels, causing low sex drive and erectile dysfunction. AIM: To assess the erectile dysfunction and sex drive in relation to testosterone serum levels in type 2 Diabetes Mellitus (DM) patients. MATERIALS AND METHODS: A total of 64 patients with type 2 DM were enrolled in this cross-sectional study, according to the treatment types they were divided into three groups, group (A): 34 patients treated with metformin, group (B): 30 patients treated with sulfonylurea and group (C): 27 healthy normal non-diabetic men are taken as control...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28179636/association-of-urinary-nerve-growth-factor-levels-with-erectile-function-in-young-men-with-type-2-diabetes-mellitus
#3
C-C Wang, C-H Liao, H-T Liu, J-M Lin, H-C Kuo
We investigated urine nerve growth factor (NGF) levels and erectile dysfunction in diabetic men <45 years of age. Urinary NGF levels were measured in 72 diabetic men and 20 control subjects without lower urinary tract symptoms or erectile dysfunction. Participants were evaluated using the International Prostate Symptom Score, quality of life index, Overactive Bladder Symptom Score (OABSS), the five-item version of the International Index of Erectile Function questionnaire (IIEF-5), the patient perception of bladder condition questionnaire, measurement of flow rate and post-void residual urine volume...
February 9, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28170483/diagnosis-and-treatment-of-pituitary-adenomas-a-review
#4
Mark E Molitch
Importance: Pituitary adenomas may hypersecrete hormones or cause mass effects. Therefore, early diagnosis and treatment are important. Observations: Prevalence of pituitary adenomas ranges from 1 in 865 adults to 1 in 2688 adults. Approximately 50% are microadenomas (<10 mm); the remainder are macroadenomas (≥10 mm). Mass effects cause headache, hypopituitarism, and visual field defects. Treatments include transsphenoidal surgery, medical therapies, and radiotherapy...
February 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28162947/fty720-supplementation-partially-improves-erectile-dysfunction-in-rats-with-streptozotocin-induced-type-1-diabetes-through-inhibition-of-endothelial-dysfunction-and-corporal-fibrosis
#5
Kai Cui, Yajun Ruan, Tao Wang, Ke Rao, Zhong Chen, Shaogang Wang, Jihong Liu
INTRODUCTION: Erectile dysfunction (ED) in patients with diabetes mellitus (DM) seriously affects their quality of life. However, these patients show a poor effect rate for oral phosphodiesterase type 5 inhibitors. Thus, new treatment methods are urgently needed. Fingolimod hydrochloride (FTY720) was approved in 2010 for the treatment of patients with the relapsing-remitting form of multiple sclerosis. AIM: To investigate whether FTY720 supplementation could ameliorate ED induced by DM (DMED)...
February 2, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28133708/tadalafil-improves-lean-mass-and-endothelial-function-in-nonobese-men-with-mild-ed-luts-in-vivo-and-in-vitro-characterization
#6
Antonio Aversa, Simona Fittipaldi, Davide Francomano, Viviana M Bimonte, Emanuela A Greco, Clara Crescioli, Luigi Di Luigi, Andrea Lenzi, Silvia Migliaccio
PURPOSE: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference. We evaluated potential effects of daily tadalafil administration on body composition and investigated its possible mechanism(s) of action in C2C12 skeletal muscle cells in vitro. METHODS: Forty-three men on stable caloric intake (mean age 48.5 ± 7; BMI 25.5 ± 0.9 kg/m(2)) complaining mild ED and/or low urinary tract symptoms (LUTS) were randomly assigned to receive tadalafil (TAD) 5 mg/daily (once-a-day=OAD-TAD; n = 23) or 20 mg on-demand (on-demand=OD-TAD; n = 20) for 2 months...
January 30, 2017: Endocrine
https://www.readbyqxmd.com/read/28109691/erectile-dysfunction-in-male-adults-with-atopic-dermatitis-and-psoriasis
#7
Alexander Egeberg, Peter R Hansen, Gunnar H Gislason, Lone Skov, Jacob P Thyssen
INTRODUCTION: Patients with psoriasis have increased risk of cardiovascular disease, but data on atopic dermatitis (AD) are less clear-cut. However, it is well-established that erectile dysfunction (ED) can serve as a risk marker for coronary disease. AIM: To investigate the incidence, prevalence, and risk of ED in men with psoriasis and AD. METHODS: The sample included all Danish men at least 30 years old. In patients with AD and psoriasis, we determined disease severity based on use of systemic therapy...
January 18, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28106289/the-involvement-of-corin-in-the-progression-of-diabetic-erectile-dysfunction-in-a-rat-model-by-down-regulating-anp-no-cgmp-signal-pathway
#8
Jian Wang, Yuanyuan Mi, Fenglai Yuan, Sheng Wu, Xiaoming You, Feng Dai, Yi Huang, Jia Cao, Jin Zhu, Boxin Xue, Lijie Zhu
This study was aimed to analyze the potential role of Corin in the procession of diabetic ED and to explore the underlying mechanism. Diabetic ED rat model was constructed and the characteristics of diabetic ED and control rats were recorded at 4, 8, 12 and 16 weeks. qRT-PCR and Western bloting were used to detected the mRNA and protein levels. Intracellular cGMP detection was accomplished using a commercial radioimmunoassay method. Vascular endothelial cell from rat corpus cavernosum spiral artery was isolated and transfected with si- Corin to analyzed the potential role of Corin...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28093175/re-treatment-of-diabetes-mellitus-induced-erectile-dysfunction-using-endothelial-progenitor-cells-genetically-modified-with-human-telomerase-reverse-transcriptase
#9
https://www.readbyqxmd.com/read/28078997/lipoprotein-a-and-cardiovascular-risk-the-show-must-go-on
#10
Niki Katsiki, Khalid Al-Rasadi, Dimitri P Mikhailidis
Lipoprotein (a) [Lp(a)] is an independent but moderate, predictor for coronary heart disease (CHD) prevalence and severity. Several established and emerging cardiovascular (CV) risk factors including age, gender, ethnicity, smoking, dyslipidemia, hypertension, obesity, type 2 diabetes mellitus, alcohol consumption, arterial stiffness and hyperuricemia have been linked to Lp(a) metabolism. Apart from CHD, Lp(a) has been also associated with non-cardiac vascular diseases and diseases associated with increased CV risk such as chronic kidney disease, metabolic syndrome, non-alcoholic fatty liver disease, erectile dysfunction, obstructive sleep apnea syndrome, inflammatory bowel diseases and human immunodeficiency virus infection...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28076881/constitutive-nos-uncoupling-and-nadph-oxidase-upregulation-in-the-penis-of-type-2-diabetic-men-with-erectile-dysfunction
#11
B Musicki, A L Burnett
Erectile dysfunction (ED) associated with type 2 diabetes mellitus (T2DM) involves dysfunctional nitric oxide (NO) signaling and increased oxidative stress in the penis. However, the mechanisms of endothelial NO synthase (eNOS) and neuronal NO synthase (nNOS) dysregulation, and the sources of oxidative stress, are not well defined, particularly at the human level. The objective of this study was to define whether uncoupled eNOS and nNOS, and NADPH oxidase upregulation, contribute to the pathogenesis of ED in T2DM men...
January 11, 2017: Andrology
https://www.readbyqxmd.com/read/28073191/are-erectile-functions-affected-by-ab0-blood-group
#12
Erdal Benli, Abdullah Çırakoglu, Ercan Ögreden, Selamettin Demir, Yasemin Kaya, Mustafa Ibas, Ali Ayyıldız, Ahmet Yüce
AIM: The aim of this study was to investigate whether there is a relationship between erectile dysfunction (ED), thought to be a vascular disease, and AB0 blood group. MATERIAL AND METHOD: The study included 350 people abiding by the study criteria who applied to our clinic from April 2012-April 2015. The patients were divided into two groups including those with ED (Group 1) and those without (Group 2). Age, blood group, IIEF-5 score and presence of additional diseases were recorded...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28065360/intracavernous-injection-of-human-umbilical-cord-blood-mononuclear-cells-improves-erectile-dysfunction-in-streptozotocin-induced-diabetic-rats
#13
Tugba Cengiz, Ecem Kaya, Didem Yilmaz Oral, Isil Ozakca, Nur Bayatli, Arzu Zeynep Karabay, Tugba Altun Ensari, Tuna Karahan, Enis Yilmaz, Serap Gur
INTRODUCTION: Erectile dysfunction (ED) worsens in men with diabetes. Human umbilical cord blood (HUCB), because of its widespread availability and low immunogenicity, is a valuable source for stem cell-based therapies. AIM: To determine the effect of intracavernous injection of HUCB mononuclear cells (MNCs) on ED in rats with diabetes induced by streptozotocin. METHODS: Thirty adult male Sprague-Dawley rats were equally divided into three groups: (i) control, (ii) diabetes induced by streptozotocin (35 mg/kg intravenously for 8 weeks), and (iii) diabetic rats treated with MNCs (1 × 10(6) cells by intracavernosal injection)...
January 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28065356/erratum-to-implanted-muscle-derived-stem-cells-ameliorate-erectile-dysfunction-in-a-rat-model-of-type-2-diabetes-but-their-repair-capacity-is-impaired-by-their-prior-exposure-to-the-diabetic-milieu
#14
https://www.readbyqxmd.com/read/28039696/ginseng-and-cancer
#15
Ahmet Unlu, Erdinc Nayir, Onder Kirca, Hale Ay, Mustafa Ozdogan
Derived from the Greek word Panacea that means 'cure for all', Ginseng (Panax) has had an important place in Chinese Medicine for many of years. As the name suggests, it is believed to be a miraculous plant effective in the treatment of many health problems. It is claimed to have many effects such as sedative, hypnotic, aphrodisiac, antidepressant, diuretic, and stimulating effects, and to be effective in the treatment of certain health problems such as diabetes, Alzheimer's disease, erectile dysfunction and infections...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28032424/relationship-between-age-and-erectile-dysfunction-diagnosis-or-treatment-using-real-world-observational-data-in-the-usa
#16
John P Mulhall, Xuemei Luo, Kelly H Zou, Vera Stecher, Aaron Galaznik
AIMS: With self-reporting of erectile dysfunction (ED) in population-based surveys, men with ED may not represent men who are bothered sufficiently to seek an ED diagnosis and treatment. We used real-world observational data to assess: 1) the prevalence of ED diagnosis or treatment by age subgroups; and 2) the relationship of age with ED diagnosis or treatment after controlling for ED-related comorbidities in the USA. METHODS: This cross-sectional study used de-identified claims data (MarketScan(®) databases; primary analysis)...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28031016/androgen-deficiency-in-aging-male-questionnaire-for-the-clinical-detection-of-testosterone-deficiency-in-a-population-of-black-sub-saharan-african-men-with-type-2-diabetes-mellitus-is-it-a-reliable-tool
#17
Ejiofor T Ugwu, Rosemary T Ikem
BACKGROUND: Androgen Deficiency in Aging Male (ADAM) questionnaire is increasingly popular for the evaluation of testosterone deficiency (TD) in Sub-Saharan African men with type 2 diabetes mellitus (T2DM). However, its reliability in this population is unknown. OBJECTIVE: To evaluate the reliability of the ADAM questionnaire for the clinical detection of testosterone deficiency in Sub-Saharan African men with T2DM Methods: Total testosterone < 8nmol/L was used as gold standard for diagnosis of TD in a cross-sectional survey of 200 males with T2DM aged 30-69 years...
December 28, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27992968/establishment-of-in%C3%A2-vitro-model-of-erectile-dysfunction-for-the-study-of-high-glucose-induced-angiopathy-and-neuropathy
#18
G N Yin, S-H Park, K-M Song, A Limanjaya, K Ghatak, N N Minh, J Ock, J-K Ryu, J-K Suh
Penile erection requires complex interaction between vascular endothelial cells, smooth muscle cells, pericytes, and autonomic nerves. Diabetes mellitus is one of the most common causes of erectile dysfunction (ED) and multiple pathogenic factors, such as cavernous angiopathy and autonomic neuropathy, are associated with diabetic ED. Although a variety of animal models of diabetic ED play an important role in understanding pathophysiologic mechanisms of diabetes-induced ED, these animal models have limitations for addressing the exact cellular or molecular mechanisms involved in ED...
December 19, 2016: Andrology
https://www.readbyqxmd.com/read/27989487/effect-of-bkca-channel-opener-ldd175-on-erectile-function-in-an-in%C3%A2-vivo-diabetic-rat-model
#19
Hyun Hwan Sung, Su Jeong Kang, Mee Ree Chae, Hye Kyung Kim, Jong Kwan Park, Chul Young Kim, Sung Won Lee
INTRODUCTION: The development of novel therapeutic options is imperative in patients with erectile dysfunction, especially those non-responsive to phosphodiesterase type 5 inhibitors. LDD175, a potent BKCa channel opener, has a relaxation effect on the in vitro cavernosal smooth muscle strip. AIM: To investigate the effect of LDD175 on erectile function using in vivo animal disease model. METHODS: Male Sprague-Dawley rats were assigned to a normal control group and seven diabetic groups: diabetic control, sildenafil (1 and 5 mg/kg), LDD175 (5 and 10 mg/kg), LDD175 5 mg/kg plus sildenafil 1 mg/kg, and LDD175 10 mg/kg plus tetraethylammonium...
December 15, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27930947/ginseng-and-obesity-observations-and-understanding-in-cultured-cells-animals-and-humans
#20
REVIEW
Longyun Zhang, Carlos Virgous, Hongwei Si
Ginseng, a traditional medical herb, has been reported having beneficial effects in fatigue, heart diseases, diabetes, immune function and erectile dysfunction. In recent years, increasing investigations have been conducted on ginseng in preventing and treating of obesity, one of the major worldwide escalating public health concerns. However, the effect and the relevant mechanisms behind how ginseng works as an antiobesity treatment are still controversial. In this review, we briefly discussed the chemical structures, metabolism and pharmacokinetics of ginseng and its major bioactive components ginsenosides...
November 23, 2016: Journal of Nutritional Biochemistry
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