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Erectile dysfunction and diabetes

Allen D Seftel
No abstract text is available yet for this article.
November 2016: Journal of Urology
L Zhang, H-Y Zhang, F-C Huang, Q Huang, C Liu, J-R Li
OBJECTIVE: We investigated the clinical value of alprostadil combined with the α-lipoic acid in treating type 2 diabetes mellitus with erectile dysfunction (DMED). PATIENTS AND METHODS: We selected a total of 76 cases of patients who were admitted to endocrinology department of our hospital from June 2014 to June 2015 and diagnosed as DMED, and the average age was (46.7 ± 7.2) years old, average course of diabetes mellitus was (6.2 ± 2.8) years and average body mass index was (25...
September 2016: European Review for Medical and Pharmacological Sciences
Khaled S Abdelkawy, Kelsey Lack, Fawzy Elbarbry
Up-regulation of arginase activity in several chronic disease conditions, including cancer and hypertension, may suggest new targets for treatment. Recently, the number of new arginase inhibitors with promising therapeutic effects for asthma, cancer, hypertension, diabetes mellitus, and erectile dysfunction has shown a remarkable increase. Arginase inhibitors may be chemical substances, such as boron-based amino acid derivatives, α-difluoromethylornithine (DMFO), and Nω-hydroxy-nor-L-arginine (nor-NOHA) or, of plant origin such as sauchinone, salvianolic acid B (SAB), piceatannol-3-O-β-D-glucopyranoside (PG) and obacunone...
October 12, 2016: European Journal of Drug Metabolism and Pharmacokinetics
Theophilus E Ugwu, Rosemary T Ikem, Babatope A Kolawole, Ignatius U Ezeani
OBJECTIVE: To determine the prevalence of hypogonadism in men with type 2 diabetes mellitus and evaluate its clinical and pathologic correlates. SUBJECTS AND METHODS: In a cross-sectional survey of 200 type 2 diabetic males aged 32-69 years, total testosterone (TT), follicle stimulating hormone, luteinizing hormone, waist circumference (WC), glycated hemoglobin, and lipids were measured. Clinical assessment of androgen deficiency was done using the androgen deficiency in aging male (ADAM) questionnaire...
September 2016: Indian Journal of Endocrinology and Metabolism
Giovanni Corona, Carlo B Giorda, Domenico Cucinotta, Piero Guida, Elisa Nada
AIMS: To present the longitudinal data of the SUBITO-DE study, a prospective survey involving male patients with new or recently diagnosed type 2 diabetes mellitus (T2DM) (<24 months). MATERIALS AND METHODS: Sexual function was assessed in male patients with T2DM at baseline (phase 1) and after a mean follow-up of 18 months (phase 2). Standard metabolic parameters and sexual and depressive symptoms were evaluated. RESULTS: Six of the 499 enrolled patients died of different causes during phase 1...
2016: PloS One
Haidar M Abdul-Muhsin, Nicholas J Jakob, Ryan M McLemore, Sean B McAdams, Mitchell R Humphreys
INTRODUCTION: To examine the infectious outcomes after the insertion of the temporary prostatic urethral stent (TPUS) in benign prostatic hyperplasia (BPH) patients. MATERIAL AND METHODS: Between November 2007 and September 2012, ninety TPUS were used in 33 patients with BPH at our institution. All patients had negative urine cultures prior to the first stent insertion. TPUS were sent for cultures at time of removal or exchange. Stents were removed at the time of definite surgical intervention, at 4-6 weeks, or when patients elected another course of treatment...
October 2016: Canadian Journal of Urology
Feng Pan, Jinwei You, Yuan Liu, Xuefeng Qiu, Wen Yu, Jiehua Ma, Lianjun Pan, Aixia Zhang, Qipeng Zhang
To better understand the molecular aetiology of type 2 diabetes mellitus-associated erectile dysfunction (T2DMED) and to provide candidates for further study of its diagnosis and treatment, this study was designed to investigate differentially expressed microRNAs (miRNAs) in the corpus cavernosum (CC) of mice with T2DMED using GeneChip array techniques (Affymetrix miRNA 4.0 Array) and to predict target genes and signalling pathways regulated by these miRNAs based on bioinformatic analysis using TargetScan, the DAIAN web platform and DAVID...
September 28, 2016: Molecular Genetics and Genomics: MGG
Chris G McMahon, Emmanuele A Jannini, Ege C Serefoglu, Wayne J G Hellstrom
The second Ad Hoc International Society for Sexual Medicine (ISSM) Committee for the Definition of Premature Ejaculation defined acquired premature ejaculation (PE) as a male sexual dysfunction characterized by a the development of a clinically significant and bothersome reduction in ejaculation latency time in men with previous normal ejaculatory experiences, often to about 3 minutes or less, the inability to delay ejaculation on all or nearly all vaginal penetrations, and the presence of negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy...
August 2016: Translational Andrology and Urology
Bolaji Oyetunde Oyelade, Abiodun Christopher Jemilohun, Sunday Adedeji Aderibigbe
INTRODUCTION: Erectile dysfunction (ED) is currently one of the most common sexual dysfunctions worldwide but it is usually underestimated because it is not a life threatening condition. The associated stigma makes men who have it to suffer in silence. This study was conducted to determine the prevalence of erectile dysfunction and the possible associated risk factors among Nigerian men. METHODS: The study was a descriptive cross-sectional population based survey among men aged 30-80 years in Ogbomoso, South-west, Nigeria...
2016: Pan African Medical Journal
Manohar J Shivananda, T S Sathyanaryana Rao
PURPOSE OF REVIEW: Sexual dysfunction is associated with many medical disorders. Lack of recognition of sexual dysfunction commonly occurs in medical practice. The impact of unrecognized sexual dysfunction affects quality of life, which in turn affects the recovery from medical illness. This article reviews the recent literature regarding sexual dysfunction in medical practice published in PubMed, Clinical key, Scopus, Google scholar from November 2014 to May 2016. RECENT FINDINGS: New findings suggest that sexual dysfunction is associated with most of the disorders affecting various systems...
November 2016: Current Opinion in Psychiatry
Stephen Odunayo Ikuerowo, Alaba Fredrick Doherty, Muftau Jimoh Bioku, Abimbola Ayodeji Abolarinwa, Adekunle Azeez Adebayo, Steves Olaide Oyeleke, Olufunmilade Akinfolarin Omisanjo
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in men in Nigeria and most cases present when the disease is already in an advanced stage. Radical prostatectomy for early prostate cancer is therefore not a commonly performed operation by urologists in Nigeria. We have had training and significant experience in radical retropubic prostatectomy. We, therefore, report the outcome of our initial experience. MATERIALS AND METHODS: We review the record of men with early prostate cancer who had radical retropubic prostatectomy in our institution from 2007 to 2015...
July 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
Maria Ida Maiorino, Giuseppe Bellastella, Mariangela Caputo, Filomena Castaldo, Maria Rosaria Improta, Dario Giugliano, Katherine Esposito
AIMS: To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly diagnosed type 2 diabetes. METHODS: In a randomized clinical trial, with a total follow-up of 8.1years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n=108) or a low-fat diet (n=107). The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women...
November 2016: Journal of Diabetes and its Complications
Shawn Choe, Christopher W Bond, Daniel A Harrington, Samuel I Stupp, Kevin T McVary, Carol A Podlasek
Erectile dysfunction (ED) has high impact on quality of life in prostatectomy, diabetic and aging patients. An underlying mechanism is cavernous nerve (CN) injury, which causes ED in up to 80% of prostatectomy patients. We examine how sonic hedgehog (SHH) treatment with innovative peptide amphiphile nanofiber hydrogels (PA), promotes CN regeneration after injury. SHH and its receptors patched (PTCH1) and smoothened (SMO) are localized in PG neurons and glia. SMO undergoes anterograde transport to signal to downstream targets...
September 6, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Carmine Gazzaruso, Adriana Coppola, Arturo Pujia, Colomba Falcone, Silvia Collaviti, Mariangela Fodaro, Pietro Gallotti, Sebastiano B Solerte, Andrea Giustina, Gabriele Pelissero, Livio Luzi, Tiziana Montalcini
No abstract text is available yet for this article.
September 2016: Journal of Geriatric Cardiology: JGC
E Onal, D Yilmaz, E Kaya, T Bastaskın, N Bayatlı, S Gur
Erectile dysfunction (ED) is associated with diabetes mellitus (DM). Pomegranate juice (PJ) is a potent antioxidant in diabetes induced oxidative stress. The aim of this study was to evaluate whether the administration of PJ ameliorates ED in streptozotocin (STZ)-diabetic rat model. Adult male Sprague-Dawley rats were divided into three groups (n=10-12, each): (1) Control, (2) STZ (25-35 mg kg(-1), intravenously, 10 weeks) induced DM, and (3) PJ (100 mg kg(-1) day(-1), 10 weeks) treated DM rats. The in vivo erectile [a ratio of intracavernosal pressure (ICP)/mean arterial pressure (MAP)] and ex vivo corpus cavernosum (CC) responses were evaluated...
September 1, 2016: International Journal of Impotence Research
Shu-Yu Tai, Ling-Feng Wang, Chih-Feng Tai, Yu-Ting Huang, Chen-Yu Chien
Few studies have investigated the relationship between chronic rhinosinusitis (CRS) and erectile dysfunction (ED). This case-control study aimed to investigate the association between CRS and the risk of ED in a large national sample. Tapping Taiwan's National Health Insurance Research Database, we identified people 30 years or older with a new primary diagnosis of CRS between 1996 and 2007. The cases were compared with sex- and age-matched controls. We identified 14 039 cases and recruited 140 387 matched controls...
2016: Scientific Reports
Kenneth J DeLay, Nora Haney, Wayne Jg Hellstrom
Erectile dysfunction (ED) is prevalent among men and its presence is often an indicator of systemic disease. Risk factors for ED include cardiovascular disease, hypertension, diabetes mellitus (DM), tobacco use, hyperlipidemia, hypogonadism, lower urinary tract symptoms, metabolic syndrome, and depression. Addressing the modifiable risk factors frequently improves a patient's overall health and increases lifespan. The literature suggests that smoking cessation, treatment of hyperlipidemia, and increasing physical activity will improve erectile function in many patients...
August 2016: World Journal of Men's Health
Kang Sup Kim, Woong Jin Bae, Su Jin Kim, Kyong-Hwa Kang, Se-Kwon Kim, Hyuk Jin Cho, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim
INTRODUCTION: We investigate the effect of active peptide from Urechis unicinctus (UU) by high temperature/pressure and ultra-wave assisted lysis on erectile dysfunction in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Forty 12-week-old Sprague-Dawley rats were used in this study. Diabetes was induced by a one-time intraperitoneal injection of streptozotocin (50mg/kg). One week later, the diabetic rats were randomly divided into four groups: normal control, untreated diabetes control, and groups treated with 100 or 500mg/kg/d UU peptide...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Giovanni Corona, Sarah Cipriani, Giulia Rastrelli, Alessandra Sforza, Edoardo Mannucci, Mario Maggi
INTRODUCTION: The atherogenic role of triglycerides (TG) remains controversial. The aim of the present study is to analyze the contribution of TG in the pathogenesis of erectile dysfunction (ED) and to verify the value of elevated TG in predicting major adverse cardiovascular events (MACE). METHODS: An unselected series of 3,990 men attending our outpatient clinic for sexual dysfunction was retrospectively studied. A subset of this sample (n = 1,687) was enrolled in a longitudinal study...
September 2016: Journal of Sexual Medicine
Joyee Basu, Sanjay Sharma
Erectile dysfunction (ED) was once assumed to be a psychological condition but has now been shown to share risk factors with cardiovascular disease including age, diabetes mellitus, smoking, hypertension and hypercholesterolaemia, suggesting an underlying vascular pathology. Evidence reveals that there is a potential link between ED and subsequent development of coronary artery disease. ED itself may also increase cardiovascular risk. The relative risk of developing coronary artery disease within ten years, in patients with moderate to severe ED, has been calculated as 14% in men aged 30-39 years and may be as high as 27% in those aged 60-69...
June 2016: Practitioner
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