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Erectile dysfunction and diabetes

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https://www.readbyqxmd.com/read/29448969/prevalence-of-erectile-dysfunction-and-associated-factors-among-diabetic-men-attending-the-diabetic-clinic-at-felege-hiwot-referral-hospital-bahir-dar-north-west-ethiopia-2016
#1
Bizuayehu Walle, Kidist Reba Lebeta, Yamrot Debela Fita, Hordofa Gutema Abdissa
OBJECTIVE: Even though several scholars have conducted study in different part of the world on erectile dysfunction in patients diagnosed with diabetes mellitus, it's magnitude vary among their finding with the range between 20 and 90%. This study aimed at assessing the prevalence of erectile dysfunction and associated factors among diabetic clients. RESULTS: A cross sectional study was conducted from January 2016 to March, 2016. Systematic random sampling technique was used...
February 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29407273/targeting-testosterone-measurements-to-patients-with-type-2-diabetes-mellitus-and-moderate-to-severe-symptomatic-erectile-dysfunction
#2
Raman Kumar, Nitin Malhotra, Jubbin J Jacob
In this study among patients with erectile dysfunction (ED) and type 2 diabetes mellitus, all 25 patients with mild ED were eugonadal. Among patients with moderate ED, 25% were eugonadal while the rest had hypogonadism; while in the severe group only 1 (3%) was eugonadal. This suggests that testosterone measurements in patient with diabetes are better targeted in patients with moderate to severe ED.
February 2, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29402797/angiotensin-ii-silencing-alleviates-erectile-dysfunction-through-down-regulating-the-rhoa-rho-kinase-signaling-pathway-in-rats-with-diabetes-mellitus
#3
Ying Zhang, Linpei Jia, Ying Zhang, Wei Ji, Hai Li
BACKGROUND/AIMS: We aim to explore the role of angiotensin (Ang)II and the RhoA/Rho kinase signaling pathway in the pathogenesis of erectile dysfunction in diabetes mellitus (DM). METHODS: Male Sprague-Dawley (SD) rats were used for experiments and short hairpin RNA (shRNA) was used to silence the AngII gene. The erectile function of rats was observed and intracavernous pressure and mean arterial pressure (ICP/MAP) were measured after electrical stimulation. Relaxation and contraction of smooth muscle in the corpus cavernosum were tested...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29370619/re-combination-of-mesenchymal-stem-cell-injection-with-icariin-for-the-treatment-of-diabetes-associated-erectile-dysfunction
#4
Allen D Seftel
No abstract text is available yet for this article.
August 2017: Journal of Urology
https://www.readbyqxmd.com/read/29368385/erectile-dysfunction-in-cirrhosis-is-impacted-by-liver-dysfunction-portal-hypertension-diabetes-and-arterial-hypertension
#5
Rafael Paternostro, Birgit B Heinisch, Thomas Reiberger, Mattias Mandorfer, Remy Schwarzer, Berit Seeland, Michael Trauner, Markus Peck-Radosavljevic, Arnulf Ferlitsch
BACKGROUND: Although several risk factors for erectile dysfunction(ED) may be present in patients with cirrhosis, data on the actual prevalence and cause of ED is limited. The International-Index-of-Erectile-Function-5(IIEF-5) is a well-validated survey to determine the presence and severity of ED in men. We assessed (i) the prevalence and severity of ED and (ii) risk factors for ED in patients with cirrhosis. METHODS: In this prospective study, ED was defined as: absent (>21 IIEF-5-points), mild (12-21) and severe (5-11)...
January 24, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29360485/actions-for-men-s-health-development-of-a-clinically-relevant-men-s-health-phenotype-and-correlation-of-systemic-and-urologic-conditions
#6
Daniel A Shoskes, Sarah C Vij, Aaron Shoskes, Yaw Nyame, Tianming Gao
OBJECTIVE: To develop a clinically relevant men's health phenotype and investigate the correlation between severity of urologic symptoms and systemic health conditions METHODS: Retrospective chart review was performed for men seeking care for benign prostatic hypertrophy (BPH), erectile dysfunction (ED) or chronic prostatitis/chronic pelvic pain syndrome (CPPS). Urologic symptoms were assessed with the International Prostate Symptom Score, Sexual Health Inventory for Men and NIH Chronic Prostatitis Symptom Score...
January 19, 2018: Urology
https://www.readbyqxmd.com/read/29336942/malleable-penile-implant-is-an-effective-therapeutic-option-in-men-with-peyronie-s-disease-and-erectile-dysfunction
#7
Mohamad Habous, Alaa Tealab, Mohammed Farag, Tarek Soliman, Ben Williamson, Saad Mahmoud, Amin Elserafy, Zenhom Mekawi, Abdallah Remeah, Mohammed Nassar, Osama Laban, Osama Abdelwahab, Saleh Binsaleh, Simone Giona, David Ralph, John Mulhall
BACKGROUND: The inflatable penile prosthesis (IPP) is typically the preferred implant for Peyronie's disease (PD) and malleable penile prostheses (MPPs) have been discouraged. AIMS: To evaluate the effectiveness and patient satisfaction of the MPP vs IPP in patients with PD. METHODS: Men with PD and erectile dysfunction who elected for penile implant surgery constituted the study population. Preoperatively, demographic and comorbidity parameters were recorded...
January 11, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29319007/calpain-inhibition-improves-erectile-function-in-diabetic-mice-via-upregulating-endothelial-nitric-oxide-synthase-expression-and-reducing-apoptosis
#8
Hao Li, Li-Ping Chen, Tao Wang, Shao-Gang Wang, Ji-Hong Liu
Calpain activation contributes to hyperglycemia-induced endothelial dysfunction and apoptosis. This study was designed to investigate the role of calpain inhibition in improving diabetic erectile dysfunction (ED) in mice. Thirty-eight-week-old male C57BL/6J mice were divided into three groups: (1) nondiabetic control group, (2) diabetic mice + vehicle group, and (3) diabetic mice + MDL28170 (an inhibitor of calpain) group. Type 1 diabetes was induced by intraperitoneal injection of streptozotocin at 60 mg kg-1 body weight for 5 consecutive days...
January 9, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29285284/activation-of-the-ngf-trka-signaling-pathway-attenuates-diabetic-erectile-dysfunction
#9
Yi Hou, Linpei Jia, Ying Zhang, Wei Ji, Hai Li
Erectile dysfunction (ED) is a common complication of diabetes mellitus (DM). The exact role of the NGF/TrkA signaling pathway in the pathogenesis of diabetic ED is largely unknown. In the present study, we investigated the role of the NGF/TrkA signaling pathway in Sprague-Dawley rats with diabetic ED. Animals were divided into 2 groups: the normal group and the DM ED model group. The model group included the blank subgroup, the negative control (NC) subgroup, the TrkA subgroup and the TrkA + NGF subgroup. Erectile function, intracavernous pressure (ICP) and mean arterial pressure were measured respectively...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29281341/functional-foods-and-nutraceuticals-as-dietary-intervention-in-chronic-diseases-novel-perspectives-for-health-promotion-and-disease-prevention
#10
Stephen Adeniyi Adefegha
Functional foods describe the importance of foods in promoting health and preventing diseases aside their primary role of providing the body with the required amount of essential nutrients such as proteins, carbohydrates, vitamins, fats, and oils needed for its healthy survival. This review explains the interaction of functional food bioactive compounds including polyphenols (phenolic acids [hydroxybenzoic acids and hydroxycinnamic acids], flavonoids [flavonols, flavones, flavanols, flavanones, isoflavones, proanthocyanidins], stilbenes, and lignans), terpenoids, carotenoids, alkaloids, omega-3 and polyunsaturated fatty acids, among others with critical enzymes (α- amylase, α- glucosidase, angiotensin-I converting enzyme [ACE], acetylcholinesterase [AChE], and arginase) linked to some degenerative diseases (type-2 diabetes, cardiovascular diseases [hypertension], neurodegenerative diseases [Alzheimer's disease] and erectile dysfunction)...
December 27, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29233142/role-of-disturbed-fatty-acids-metabolism-in-the-pathophysiology-of-diabetic-erectile-dysfunction
#11
Mohamed Raâfet Ben Khedher, Houda Bouhajja, Samia Haj Ahmed, Mohamed Abid, Kamel Jamoussi, Mohamed Hammami
BACKGROUND: Vasculogenic erectile dysfunction (VED) is considered as a common complication among people with type 2 diabetes (T2D). We tested whether changes in fatty acid (FAs) classes measured in erythrocytes are associated with increased risk of diabetic VED along with related risk factors. METHODS: We assessed erythrocyte FAs composition, lipid peroxidation parameters and inflammatory cytokines among 72 T2D men with VED, 78 T2D men without VED and 88 healthy volunteers with similar age...
December 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29219281/impact-on-sexual-function-of-surgical-treatment-in-rectal-cancer
#12
Pedro Costa, João M Cardoso, Hugo Louro, Jorge Dias, Luís Costa, Raquel Rodrigues, Paulo Espiridião, Jorge Maciel, Luís Ferraz
INTRODUCTION: The development of new surgical techniques and medical devices, like therapeutical multimodal approaches has allowed for better outcomes on patients with rectal cancer (RCa). Owing to that, an increased awareness and investment towards better outcomes regarding patients' sexual and urinary function has been recently observed. AIM: Evaluate and characterize the sexual dysfunction of patients submitted to surgical treatment for RCa. MATERIALS AND METHODS: An observational retrospective study including all male patients who underwent a surgical treatment for RCa between January 2011 December 2014 (n=43) was performed, complemented with an inquiry questionnaire to every patient about its sexual habits and level of function before and after surgery...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29203844/complications-functional-and-quality-of-life-outcomes-following-primary-and-secondary-implantation-of-penile-prosthesis-at-a-tertiary-referral-center
#13
Bernhard Ralla, Irena Goranova, Niels Börnstein, Frank Friedersdorff, Andreas Maxeiner, Ahmed Magheli, Stefan Hinz, Joerg Neymeyer, Kurt Miller, Jonas Busch
The implantation of a penile prosthesis (PP) may be recommended in patients with severe erectile dysfunction (ED) who do not respond to conservative treatments. The aim of this study was to evaluate complications, as well as functional and quality of life outcomes following primary and secondary implantation of PP at a tertiary referral center. In this retrospective study, a total of 51 patients (41 patients with primary (PPP) and 10 with secondary PP (SPP)) were included. Patients and operative characteristics were recorded and complications were analyzed using the Clavien-Dindo classification...
December 4, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29200555/erectile-dysfunction-an-underestimated-presentation-in-patients-with-diabetes-mellitus
#14
Zeeshan Anwar, Vishal Sinha, Sayantanava Mitra, Ashwani Kumar Mishra, Mahboobul Hasan Ansari, Abhishek Bharti, Vipin Kumar, Ashwini Kumar Nigam
Introduction: Erectile dysfunction (ED) is a common complication of diabetes mellitus. ED, like other sexual disorders, is often under-reported and under-diagnosed, as talking about sex is considered a taboo in our society. Methodology: All the male patients with diabetes mellitus (with or without active complaints of ED) attending Medicine or Psychiatry OPD of the institute during the study period were enrolled in the study. They were investigated for their body-mass index (BMI), blood sugar and lipid profile; and were assessed on HAM-D, General Health Questionnaire-30, IIEF, sex myth checklist and QOL Instrument for Indian Diabetes Patients (QOLID)...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29198514/erectile-dysfunction-medications-and-treatment-for-cardiometabolic-risk-factors-a-pharmacoepidemiologic-study
#15
Sean C Skeldon, Lucy Cheng, Steven G Morgan, Allan S Detsky, S Larry Goldenberg, Michael R Law
BACKGROUND: Erectile dysfunction (ED) can be a sentinel marker for future cardiovascular disease and has been described as providing a "window of curability" for men to receive targeted cardiovascular risk assessment. AIM: To determine whether the prescription of phosphodiesterase type 5 inhibitors (PDE5is) for ED leads to the detection and treatment of previously undiagnosed cardiometabolic risk factors. METHODS: We performed a retrospective population-based cohort study of residents of British Columbia, Canada using linked health care databases from 2004 to 2011...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29196693/relationship-between-erectile-dysfunction-and-the-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios
#16
Murat Sambel, Metin Kilic, Murat Demirbas, Efe Onen, Sedat Oner, Abdullah Erdogan, Mustafa Murat Aydos
The most important cause of erectile dysfunction (ED) among aging men is organic disease due to vascular disturbance that is often caused by atherosclerosis. Recently, studies have shown that atherosclerosis can manifest as an active inflammatory process rather than as passive vascular injury caused by lipid infiltration. Our study aimed to examine the association of ED with the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR), both of which are markers of inflammation. Between December 2014 and May 2015, 101 male patients aged 40-70 years who were seen at our institute due to ED were included in this study...
December 1, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29184786/phosphodiesterase-type-5-inhibitors-usage-and-prostate-cancer-a-match-paired-analysis
#17
G Luke Machen, M Hasan Rajab, Jessica Pruszynski, K Scott Coffield
Background: To treat erectile dysfunction (ED), phosphodiesterase type 5 inhibitors (PDE5i) are commonly used. However, to date, only a few studies exist evaluate a possible effect on the incidence of prostate cancer. One such study completed by the authors' institution suggested men who use PDE5i for ED may have a lower incidence of prostate cancer. This study was meant to address some of the shortcomings of the former study and further characterize the link between prostate cancer and PDE5i use...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29178359/elevated-luteinizing-hormone-despite-normal-testosterone-levels-in-older-men-natural-history-risk-factors-and-clinical-features
#18
Robert J A H Eendebak, Tomas Ahern, Agnieszka Swiecicka, Stephen R Pye, Terence W O'Neill, Gyorgy Bartfai, Felipe F Casanueva, Mario Maggi, Gianni Forti, Aleksander Giwercman, Thang S Han, Jolanta Słowikowska-Hilczer, Michael E J Lean, Margus Punab, Neil Pendleton, Brian G Keevil, Dirk Vanderschueren, Martin K Rutter, Gindo Tampubolon, Royston Goodacre, Ilpo T Huhtaniemi, Frederick C W Wu
OBJECTIVE: Elevated luteinizing hormone (LH) with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated with the development of high LH (HLH, LH >9.4 U/L) in ageing men with normal T (T ≥ 10.5 nmol/L). DESIGN, PATIENTS AND MEASUREMENTS: We conducted a 4.3-year prospective observational study of 3369 community-dwelling European men aged 40-79 years...
November 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29171080/testosterone-therapy-for-sexual-dysfunction-in-men-with-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
M Algeffari, C N Jayasena, P MacKeith, A Thapar, W S Dhillo, N Oliver
AIM: To evaluate the effectiveness of testosterone therapy on a range of sexual function domains in men with Type 2 diabetes. METHOD: Electronic databases were searched for studies investigating the effect of testosterone therapy on sexual function in men with Type 2 diabetes. All randomized controlled trials were considered for inclusion if they compared the efficacy of testosterone therapy with that of placebo and reported sexual function outcomes. Statistical analysis was performed using a random-effects model, and heterogeneity was expressed using the I(2) statistic...
November 24, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29170014/-treatment-by-stem-cell-therapy-of-erectile-dysfunction-of-diabetic-origin-state-of-the-art
#20
R El Osta, V Decot, D Bensoussan, J F Stoltz, P Eschwege, J Hubert
PURPOSE: Review of various publications on stem cell therapy to treat erectile dysfunction of diabetic origin. MATERIAL AND METHODS: Bibliographic search in PUBMED performed using the keywords cell therapy strain/erectile dysfunction associated with diabetes. Among the 51 articles obtained from the PUBMED research, we selected 16 articles for their specificity of studying erectile dysfunction (DE) related to diabetes. RESULTS: Different types of stem cells have been studied: adipose derived mesenchymal stem cells/bone marrow derived mesenchymal stem cells as well as progenitor endothelial cells...
November 20, 2017: Progrès en Urologie
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