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Isopropyl alcohol

Borong Yu, Chentai Cao, Pan Li, Mei Mao, Qiwen Xie, Liangbao Yang
Morphine, a kind of illicit drugs, is also one of the main heroin metabolites. In consideration of a noninvasive way to monitor and identify drug abuse during forensic cases, the urine samples are usually detected. Here, colloidal gold nanorods (Au NRs) were introduced to act as active substrate, because of the strong optical extinction and spectral tunability of the longitudinal surface plasmon resonance (SPR). Thus, well surface-enhanced Raman spectra of morphine even at low concentrations could be obtained by portable Raman spectrometer...
August 15, 2018: Talanta
Nitin H Dhekale, Dattatray B Gunjal, Anil H Gore, Yagnakirankumar Komaravolu, K Hima Bindu, Govind B Kolekar
Chiral separation by normal phase high performance liquid chromatography is one of the most powerful technique to quantify the chiral purity of the compounds. In this study, a novel, simple, and specific analytical method was proposed to ascertain the chiral purity of alvimopan (ALV). The normal phase HPLC method was developed based on cellulose tris (3,5-dichlorophenylcarbamate) stationary phase. The separation of ALV isomers achieved by using column CHIRALPAK IC (250 × 4.6 mm, 5 μm), mobile phase n-hexane: isopropyl alcohol: ethanol: diethylamine (650:200:150:5 v/v), column oven temperature 30°C, flow rate 1...
May 21, 2018: Chirality
Marylaine Pérez-Malo, Gergely Szabó, Elisabeth Eppard, Adrienn Vagner, Ernő Brücher, Imre Tóth, Alessandro Maiocchi, Eul Hyun Suh, Zoltán Kovács, Zsolt Baranyai, Frank Rösch
Typically, the synthesis of radiometal-based radiopharmaceuticals is performed in buffered aqueous solutions. We found that the presence of organic solvents like ethanol increased the radiolabeling yields of [68 Ga]Ga-DOTA (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacatic acid). In the present study, the effect of organic cosolvents [ethanol (EtOH), isopropyl alcohol, and acetonitrile] on the radiolabeling yields of the macrocyclic chelator DOTA with several trivalent radiometals (gallium-68, scandium-44, and lutetium-177) was systematically investigated...
May 10, 2018: Inorganic Chemistry
Benjamin D Freemyer, Michael R Migden, Sirunya Silapunt
Terra firma-forme dermatosis (TFFD) is a benign and likely underdiagnosed disorder with relatively few reports in the literature. A 46-year-old woman presented to our clinic with a 3-year history of linear TFFD extending from the upper sacrum to the midline upper back. It initially was thought to be acanthosis nigricans or lichen simplex chronicus, and a topical steroid cream was applied without success. The lesion ultimately was removed by rubbing with isopropyl alcohol, which confirmed a diagnosis of TFFD...
March 2018: Cutis; Cutaneous Medicine for the Practitioner
I Neri, F Savoia, V Tengattini, A Sechi, P Rucci, A Patrizi
Terra firma-forme dermatosis (TFFD) is an acquired benign disorder that is characterized by brown-gray patches or plaques, presenting as dirt-like pigmented areas (1, 2). The diagnosis is usually confirmed by the clearing with isopropyl or 70% ethyl alcohol swab, that is also the gold standard of treatment. Dermoscopy of TFFD may show large polygonal plate-like brown scales arranged together giving a mosaic or cobblestone pattern (3) This article is protected by copyright. All rights reserved.
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Sriram Valavala, Nareshvarma Seelam, Subbaiah Tondepu, V Shanmukha Kumar Jagarlapudi, Vivekanandan Sundarmurthy
A simple, sensitive, accurate, robust headspace gas chromatographic method was developed for the quantitative determination of acetone and isopropyl alcohol in tartaric acid-based pellets of dipyridamole modified release capsules. The residual solvents acetone and isopropyl alcohol were used in the manufacturing process of the tartaric acid-based pellets of dipyridamole modified release capsules by considering the solubility of the dipyridamole and excipients in the different manufacturing stages. The method was developed and optimized by using fused silica DB-624 (30 m × 0...
2018: Journal of Analytical Methods in Chemistry
Guillaume Falco, Nathanael Guigo, Luc Vincent, Nicolas Sbirrazzuoli
This work shows how furan ring-opening reactions were controlled by polymerization conditions to tune the cross-link density in biobased poly(furfuryl alcohol) (PFA). The influence of water and isopropyl alcohol (IPA) on the polymerization of furfuryl alcohol (FA), and particularly on furan ring-opening, was investigated by means of 13C NMR and FT-IR spectroscopy. Results indicated that formation of open structures were favored in presence of solvents thus leading to modification of thermo-mechanical properties compared to PFA cross-linked without solvent...
April 23, 2018: ChemSusChem
Abdul Ahad, Faiyaz Shakeel, Omar Ali Alfaifi, Mohammad Raish, Ajaz Ahmad, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea
The purpose of the present study was to determine the solubility of raloxifene hydrochloride (RHCl) in ten solvents: water, ethanol, isopropyl alcohol (IPA), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), Transcutol, 1-butanol, dimethyl sulfoxide (DMSO), and ethyl acetate (EA) at temperatures of 298.2-323.2 K and a pressure of 0.1 MPa. The solubility data obtained was fitted upon "Apelblat and Van't Hoff" equations. The maximum mole fraction solubility of RHCl was obtained in DMSO (5...
April 18, 2018: International Journal of Pharmaceutics
Rakesh Mogul, Gregory A Barding, Sidharth Lalla, Sooji Lee, Steve Madrid, Ryan Baki, Mahjabeen Ahmed, Hania Brasali, Ivonne Cepeda, Trevor Gornick, Shawn Gunadi, Nicole Hearn, Chirag Jain, Eun Jin Kim, Thi Nguyen, Vinh Bao Nguyen, Alex Oei, Nicole Perkins, Joseph Rodriguez, Veronica Rodriguez, Gautam Savla, Megan Schmitz, Nicholas Tedjakesuma, Jillian Walker
Spacecraft assembly facilities are oligotrophic and low-humidity environments, which are routinely cleaned using alcohol wipes for benchtops and spacecraft materials, and alkaline detergents for floors. Despite these cleaning protocols, spacecraft assembly facilities possess a persistent, diverse, dynamic, and low abundant core microbiome, where the Acinetobacter are among the dominant members of the community. In this report, we show that several spacecraft-associated Acinetobacter metabolize or biodegrade the spacecraft cleaning reagents of ethanol (ethyl alcohol), 2-propanol (isopropyl alcohol), and Kleenol 30 (floor detergent) under ultraminimal conditions...
April 19, 2018: Astrobiology
Allan Lieberman, Luke Curtis
In this case report, we describe a 66-year-old man who developed multiple adverse reactions beginning at age 56 after exposure to several azole antifungal drugs including ketoconazole and fluconazole. He also had a history of more than 40 years exposure to chemicals including pesticides, wood preservatives, fertilizers, and welding chemicals. His reactions involved dehydration (requiring several liters of intravenous fluids in less than an hour to alleviate this condition), angioedema, nausea, tinnitus, hypotension, and difficulty breathing...
April 18, 2018: Drug Safety—Case Reports
Paul Andrew Christensen, Zeinab T A W Mashhadani, Abd Halim Bin Md Ali, Michael A Carroll, Philip A Martin
This paper reports in-situ Fourier Transform Infra Red (FTIR) spectroscopic studies on the non-thermal plasma reaction of isopropyl alcohol in dinitrogen at Macor (a ceramic containing oxides of Al, Mg and Si) and the analogous thermally-driven process. Whilst isopropyl alcohol did not react at the Macor at temperatures up to 600°C, the study of the non-thermal plasma-driven process at the ceramic led to unexpected chemistry hitherto not observed, primarily the reaction of IPA in dinitrogen at short timescales to produce methane, HCN, acetone and "cold" CO at ca...
April 17, 2018: Journal of Physical Chemistry. A
Angélica Feltrin Dos Santos, Fernanda Sandes de Lucena, Ana Flávia Sanches Borges, Paulo Noronha Lisboa-Filho, Adilson Yoshio Furuse
STATEMENT OF PROBLEM: Despite numerous advantages such as high strength, the bond of yttria-stabilized zirconia polycrystal (Y-TZP) to tooth structure requires improvement. PURPOSE: The purpose of this in vitro study was to evaluate the incorporation of TiO2 nanotubes into zirconia surfaces and the bond strength of resin cement to the modified ceramic. MATERIAL AND METHODS: TiO2 nanotubes were produced by alkaline synthesis, mixed with isopropyl alcohol (50 wt%) and applied on presintered zirconia disks...
April 5, 2018: Journal of Prosthetic Dentistry
Wangchang Geng, Shaobing Ge, Xiaowei He, Shan Zhang, Junwei Gu, Xiaoyong Lai, Hong Wang, Qiuyu Zhang
Porous solid with multimodal pore size distribution provides plenty of advantages including large specific surface area and superior mass transportation to achieve the high gas-sensing performances. In this study, α-Fe2O3 nanoparticles with bimodal porous structures were prepared successfully through a nanocasting pathway, adopting the bicontinuous 3D cubic symmetry mesoporous silica KIT-6 as the hard template. Its structure and morphology were characterized by X-ray Diffraction, Nitrogen adsorption-desorption, Transmission electron microscope and so on...
April 5, 2018: ACS Applied Materials & Interfaces
Peili Gong, Nan Wang, Lei Guan, Wei Lai
The aim of these two clinical studies was to evaluate the sensory characteristics and irritation potential of a prototype disinfectant spray (containing 0.13% w/v benzalkonium chloride and a cooling agent) in subjects with experimental wounds. The pilot study was a single center, "replicated latinClinicalTrials.ClinicalTrials. square design," randomized and double-blinded study. The pivotal study was a single center, randomized, controlled, crossover, double-blinded study, following a direct comparison test design of the study products...
May 2017: Journal of Cosmetic Science
Nathanael Heckmann, Lakshmanan Sivasundaram, K Soraya Heidari, Alexander E Weber, Erik N Mayer, Reza Omid, C Thomas Vangsness, George F Hatch
PURPOSE: To investigate the efficacy of various skin preparations at eradicating Propionibacterium acnes in the dermal layer of the skin. METHODS: Twelve healthy volunteers consented to participate in this study. Each subject's upper back was prepped using 4 different techniques: an isopropyl alcohol control, chlorhexidine gluconate paint, chlorhexidine gluconate plus a mechanical scrub, and a high-concentration chlorhexidine gluconate plus a mechanical scrub. A 3-mm dermal punch biopsy specimen was obtained at each preparation site...
March 23, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Dhika Aditya Gandamana, Bin Wang, Ciputra Tejo, Benoit Bolte, Fabien Gagosz, Shunsuke Chiba
A new protocol for the deoxygenation of alcohols and the hydrogenation of alkenes under Brønsted acid catalysis has been developed. The method is based on the use of a benzyl or an isopropyl ether as a traceless hydrogen atom donor and involves an intramolecular hydride transfer as a key step that can be achieved in regio- and stereoselective manners.
March 25, 2018: Angewandte Chemie
Patrick Chow Ng, Brit J Long, William Tyler Davis, Daniel J Sessions, Alex Koyfman
Toxic alcohols are a group of substances containing a hydroxyl group not meant to be ingested. They are the cause of a significant number of accidental and non-accidental exposures. Toxic alcohol poisoning can be associated with a significant degree of morbidity and mortality if not promptly recognized and treated. This review describes the clinical presentation and an approach to the recognition and management for toxic alcohol poisoning. Toxic alcohols classically refer to a group of alcohols not meant for ingestion...
March 22, 2018: Internal and Emergency Medicine
Sonia Hines, Elizabeth Steels, Anne Chang, Kristen Gibbons
BACKGROUND: Postoperative nausea and vomiting (PONV) is a common, unpleasant phenomenon and current therapies are not always effective for all patients. Aromatherapy has been suggested as an addition to the available treatment strategies. This review was originally published in 2012 and updated in 2017. OBJECTIVES: The main objective was to establish the efficacy and safety of aromatherapy comparable to standard pharmacological treatments for PONV in adults and children...
March 10, 2018: Cochrane Database of Systematic Reviews
Wenyu Zhang, Libo Sun, Jean Marie Vianney Nsanzimana, Xin Wang
Silicene has recently received increasing interest due to its unique properties. However, the synthesis of silicene remains challenging, which limits its wide applications. In this work, a top-down lithiation and delithiation process is developed to prepare few layer silicene-like nanosheets from ball-milled silicon nanopowders. It is found that delithiation solvent plays a critical role in the structure evolution of the final products. The use of isopropyl alcohol renders 2D silicene-like products 30-100 nm in length and ≈2...
April 2018: Advanced Materials
Matthew N Simmons, Andrew D Neeb, Marta Johnson-Mitchell
OBJECTIVE: To compare 3 prophylactic regimens to assess their impact on postbiopsy sepsis incidence. METHODS: Data were reviewed for 829 consecutive patients who underwent prostate biopsy in a community practice setting between January 2013 and October 2017. Group 1 patients received ciprofloxacin 500 mg two times a day orally for 4 days starting the day prior to biopsy and gentamicin 80 mg intramuscularly 20 minutes prior to biopsy. From April 2015 to October 2017, 2 groups of patients were followed in parallel in a randomized manner...
February 27, 2018: Urology
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