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https://www.readbyqxmd.com/read/28321695/solubility-and-thermodynamic-analysis-of-antihypertensive-agent-nitrendipine-in-different-pure-solvents-at-the-temperature-range-of-298-15-to-318-15%C3%A2-k
#1
Abdul Ahad, Faiyaz Shakeel, Mohammad Raish, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea
The aim of the present study was to ascertain the solubility of nitrendipine (NP), an antihypertensive drug in six different pure solvents such as water, ethyl acetate (EA), ethanol, isopropyl alcohol (IPA), polyethylene glycol-400 (PEG-400), and Transcutol at temperature from 298.15 to 318.15 K under atmospheric pressure (p) of 0.1 MPa. Experimental solubility data of NP was fitted with Apelblat and ideal models. The mole fraction solubility of NP was found maximum in PEG-400 (6.85 × 10(-2) at 318.15 K) followed by Transcutol (4...
March 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28301624/photodynamic-therapy-effectively-treats-actinic-keratoses-without-pre-illumination-incubation-time
#2
Jessica Gandy, Brian Labadie, Dina Bierman, Christopher Zachary
<p>BACKGROUND: Actinic keratoses (AKs) are dysplastic lesions of the epidermis that have the potential to progress to non-melanoma skin cancers (NMSC). Traditional photodynamic therapy (PDT) requires a pre-illumination incubation time, which adds to overall in-office time and has been linked to pain. Our group has found a novel protocol to effectively treat AKs with PDT that eliminates the pre-illumination incubation period and uses 2 back-to-back cycles of 16 minute 40 seconds.</p> <p>METHODS: The patient was prepped with soapy water and isopropyl alcohol, and thick AKs were descaled with a curette...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28267322/stereorigid-osso-type-group-4-metal-complexes-in-the-ring-opening-polymerization-of-rac-lactide
#3
Rosita Lapenta, Antonio Buonerba, Assunta De Nisi, Magda Monari, Alfonso Grassi, Stefano Milione, Carmine Capacchione
The synthesis and characterization of a series of group 4 metal complexes of general formula {OSSOX}M(OR)2 (X = R = (t)Bu, M = Zr (1); X = cumyl, M = Zr, R = (t)Bu (2); X = cumyl, M = Ti, R = (i)Pr (4); X = cumyl, M = Hf, R = (t)Bu (5)) and {OSSOX}2Zr (X = Cl (3)) supported by o-phenylene-bridged bis(phenolato) ligands (OSSOtBu-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-di-tert-butyphenol); OSSOCum-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-bis(2-phenylpropan-2-yl)phenol); OSSOCl-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-dichlorophenol)) are described herein...
March 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28253227/reported-adverse-health-effects-in-children-from-ingestion-of-alcohol-based-hand-sanitizers-united-states-2011-2014
#4
Cynthia Santos, Stephanie Kieszak, Alice Wang, Royal Law, Joshua Schier, Amy Wolkin
Hand sanitizers are effective and inexpensive products that can reduce microorganisms on the skin, but ingestion or improper use can be associated with health risks. Many hand sanitizers contain up to 60%-95% ethanol or isopropyl alcohol by volume, and are often combined with scents that might be appealing to young children. Recent reports have identified serious consequences, including apnea, acidosis, and coma in young children who swallowed alcohol-based (alcohol) hand sanitizer (1-3). Poison control centers collect data on intentional and unintentional exposures to hand sanitizer solutions resulting from various routes of exposure, including ingestion, inhalation, and dermal and ocular exposures...
March 3, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28241955/clinical-issues-march-2017
#5
Sharon A Van Wicklin
Using one flexible endoscope for an upper and lower gastrointestinal (GI) endoscopy procedure Key words: flexible endoscope, esophagogastroduodenoscopy, colonoscopy, enteroscope, risk assessment. Enhanced methods for processing flexible duodenoscopes Key words: flexible duodenoscopes, liquid chemical sterilization, ethylene oxide sterilization, low-temperature sterilization, risk assessment. Modification of the Spaulding classification Key words: Spaulding classification, critical items, semicritical items, mucous membranes, risk assessment...
March 2017: AORN Journal
https://www.readbyqxmd.com/read/28239393/thermo-sensitive-polymer-nanospheres-as-a-smart-plugging-agent-for-shale-gas-drilling-operations
#6
Wei-Ji Wang, Zheng-Song Qiu, Han-Yi Zhong, Wei-An Huang, Wen-Hao Dai
Emulsifier-free poly(methyl methacrylate-styrene) [P(MMA-St)] nanospheres with an average particle size of 100 nm were synthesized in an isopropyl alcohol-water medium by a solvothermal method. Then, through radical graft copolymerization of thermo-sensitive monomer N-isopropylacrylamide (NIPAm) and hydrophilic monomer acrylic acid (AA) onto the surface of P(MMA-St) nanospheres at 80 °C, a series of thermo-sensitive polymer nanospheres, named SD-SEAL with different lower critical solution temperatures (LCST), were prepared by adjusting the mole ratio of NIPAm to AA...
2017: Pet Sci
https://www.readbyqxmd.com/read/28193100/corneal-antinociceptive-effect-of-%C3%AE-bisabolol
#7
COMPARATIVE STUDY
Gisele Façanha Diógenes Teixeira, Flávio Nogueira da Costa, Adriana Rolim Campos
CONTEXT: (-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. OBJECTIVE: To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent. MATERIALS AND METHODS: Acute corneal nociception was induced by the local application of hypertonic saline (5 M NaCl; 20 μL) to the corneal surface of Swiss mice (n = 8/group) 60 min after topical treatment with solutions or ointment containing BISA (50-200 mg/mL)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28174074/inactivation-of-rabies-virus
#8
Guanghui Wu, David Selden, Anthony R Fooks, Ashley Banyard
Rabies virus is a notifiable pathogen that must be handled in high containment facilities where national and international guidelines apply. For the effective inactivation of rabies virus, a number of reagents were tested. Virkon S (1%) solution caused more than 4log reduction of rabies virus in culture medium supplemented with 10% foetal calf serum within 1min. Isopropyl alcohol (70%) treatment resulted in >3log reduction of rabies virus within 20s when applied at a ratio of 19:1, making it a suitable agent for surface decontamination whereas 70% ethanol was ineffective...
May 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28167854/estimation-of-mean-number-of-daily-hand-hygiene-procedures-per-patient-can-represent-an-effective-and-easy-understandable-method-to-evaluate-adherence-experience-in-a-tertiary-care-pediatric-hospital-of-northern-italy
#9
P Tatarelli, I Lorenzi, I Caviglia, R A Sacco, D LA Masa, E Castagnola
INTRODUCTION: Hand decontamination with alcohol-based antiseptic agents is considered the best practise to reduce healthcare associated infections. We present a new method to monitor hand hygiene, introduced in a tertiary care pediatric hospital in Northern Italy, which estimates the mean number of daily hand decontamination procedures performed per patient. METHODS: The total amount of isopropyl alcohol and chlorhexidine solution supplied in a trimester to each hospital ward was put in relation with the number of hospitalization days, and expressed as litres/1000 hospitalization-days (World Health Organization standard method)...
December 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28132972/a-new-desorption-method-for-removing-organic-solvents-from-activated-carbon-using-surfactant
#10
Mitsuo Hinoue, Sumiyo Ishimatsu, Yukiko Fueta, Hajime Hori
OBJECTIVES: A new desorption method was investigated, which does not require toxic organic solvents. Efficient desorption of organic solvents from activated carbon was achieved with an ananionic surfactant solution, focusing on its washing and emulsion action. METHODS: Isopropyl alcohol (IPA) and methyl ethyl ketone (MEK) were used as test solvents. Lauryl benzene sulfonic acid sodium salt (LAS) and sodium dodecyl sulfate (SDS) were used as the surfactant. Activated carbon (100 mg) was placed in a vial and a predetermined amount of organic solvent was added...
January 28, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28129183/differential-ring-oscillator-based-capacitance-sensor-for-microfluidic-applications
#11
Kaveh Mohammad, Douglas J Thomson
A simple high frequency capacitance sensor with 180 aF sensitivity is designed for a wide range of microfluidic applications. The sensor is implemented utilizing differential ring oscillators operating at [Formula: see text] MHz with a differential signal at [Formula: see text] MHz. The sensor occupies [Formula: see text] cm × 2 cm on a printed circuit board. The sensor is tuned using two precision variable capacitors and has a full scale range of [Formula: see text] pF. The sensor was able to detect less than 1% Isopropyl Alcohol in DI water and to detect 15 μm polystyrene spheres flowing over 25 μm lines and spaces coplanar electrodes in a microfluidic channel...
April 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28128218/highly-flexible-and-transparent-ag-nanowire-electrode-encapsulated-with-ultra-thin-al2o3-thermal-ambient-and-mechanical-stabilities
#12
Byungil Hwang, Youngseo An, Hyangsook Lee, Eunha Lee, Stefan Becker, Yong-Hoon Kim, Hyoungsub Kim
There is an increasing demand in the flexible electronics industry for highly robust flexible/transparent conductors that can withstand high temperatures and corrosive environments. In this work, outstanding thermal and ambient stability is demonstrated for a highly transparent Ag nanowire electrode with a low electrical resistivity, by encapsulating it with an ultra-thin Al2O3 film (around 5.3 nm) via low-temperature (100 °C) atomic layer deposition. The Al2O3-encapsulated Ag nanowire (Al2O3/Ag) electrodes are stable even after annealing at 380 °C for 100 min and maintain their electrical and optical properties...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28089672/isopropyl-alcohol-is-as-efficient-as-chlorhexidine-to-prevent-contamination-of-blood-cultures
#13
Jovanna Martínez, Juan H Macías, Virginia Arreguín, Jose A Álvarez, Alejandro E Macías, Juan L Mosqueda-Gómez
BACKGROUND: False-positive blood cultures can lead to unnecessary risks and misuse of antibiotics; to reduce rates of false-positives, it would be useful to determine whether use of an antiseptic with a prolonged effect is required. METHODS: Clinical study of efficacy (blinded and randomized) to compare the rate of blood culture contamination when skin antisepsis was performed with 70% isopropyl alcohol or 2% chlorhexidine gluconate in 70% isopropyl alcohol in 2 hospitals...
January 12, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28088896/formulation-and-optimization-of-lansoprazole-pellets-using-factorial-design-prepared-by-extrusion-spheronization-technique-using-carboxymethyl-tamarind-kernel-powder
#14
Sagar Sopanrao Muley, Tanaji Nandgude, Sushilkumar Poddar
BACKGROUND: In the present study, Lansoprazole pellets were prepared employing a novel excipient Carboxymethyl tamarind kernel powder (CMTKP) using extrusion-spheronization technique. Pellet formulation was optimized for formulation parameters (concentration of microcrystalline cellulose, CMTKP, croscarmellose sodium and isopropyl alcohol). METHODS: Process parameters (speed and duration of spheronization) were optimized using factorial design. The pellets were evaluated for yield, bulk and tapped density, particle size, hardness, drug content, disintegration time and drug release...
January 13, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28088876/desolventizing-of-jatropha-curcas-oil-from-azeotropes-of-solvents-using-ceramic-membranes
#15
Naira Carniel, Giovani L Zabot, Marshall Paliga, Marcelo L Mignoni, Marcio A Mazutti, Wagner L Priamo, J V Oliveira, Marco Di Luccio, Marcus V Tres
The separation of Jatropha curcas oil from azeotropes of ethyl alcohol-n-hexane and isopropyl alcohol-n-hexane using ceramic membranes with different cutoffs (5, 10 and 20 kDa) is presented. The mass ratios of oil:azeotropes (O:S) studied were 1:3 for feeding pressures of 0.1, 0.2 and 0.3 MPa, and 1:1 for the feeding pressure of 0.1 MPa. Isopropyl alcohol was the best solvent for the membranes conditioning to permeate n-hexane (240 kg/m(2 )h). In the separation of J. curcas oil and azeotropes of solvents, both membranes showed oil retention and total flux decreases with time...
February 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28072611/baby-shampoo-versus-povidone-iodine-or-isopropyl-alcohol-in-reducing-eyelid-skin-bacterial-load
#16
Giancarlo A Garcia, Christine V Nguyen, Marc A Yonkers, Jeremiah P Tao
PURPOSE: Baby shampoo is used as an alternative surgical skin preparation, but the evidence supporting its use is scarce with no descriptions of efficacy in the periocular region. The authors compare the efficacy of baby shampoo, povidone-iodine (PI, Betadine) and isopropyl alcohol (IA) in reducing eyelid skin bacterial load. METHODS: Prospective, randomized, comparative, and interventional trial. Bacterial load on adult, human eyelid skin was quantitated before and after cleansing with 1) dilute baby shampoo, 2) 10% PI, or 3) 70% IA...
January 6, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28029386/occurrence-of-organophosphorus-flame-retardants-on-skin-wipes-insight-into-human-exposure-from-dermal-absorption
#17
Xiaotu Liu, Gang Yu, Zhiguo Cao, Bin Wang, Jun Huang, Shubo Deng, Yujue Wang
This study surveyed occurrences and influencing factors of organophosphorus flame retardants (PFRs) on skin surface. Skin wipe samples from palms, back-of-hands and forearms of 30 adults were collected by using gauze pads soaked in isopropyl alcohol in Beijing, China. Tris(chloropropyl) phosphate isomers (∑TCPP), tris(2-chloroethyl) phosphate (TCEP) and triphenyl phosphate (TPHP) were the most abundant compounds with detection frequencies higher than 97%. ∑TCPP showed the highest mean level (4.6μg/m(2)), followed by TPHP (2...
October 28, 2016: Environment International
https://www.readbyqxmd.com/read/27993395/a-sensitive-and-accurate-method-for-the-determination-of-perfluoroalkyl-and-polyfluoroalkyl-substances-in-human-serum-using-a-high-performance-liquid-chromatography-online-solid-phase-extraction-tandem-mass-spectrometry
#18
Chang Ho Yu, Bhupendra Patel, Marilou Palencia, Zhihua Tina Fan
A selective, sensitive, and accurate analytical method for the measurement of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in human serum, utilizing LC-MS/MS (liquid chromatography-tandem mass spectrometry), was developed and validated according to the Centers for Disease Control and Prevention (CDC) guidelines for biological sample analysis. Tests were conducted to determine the optimal analytical column, mobile phase composition and pH, gradient program, and cleaning procedure. The final analytical column selected for analysis was an extra densely bonded silica-packed reverse-phase column (Agilent XDB-C8, 3...
January 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27976496/synthesis-and-properties-of-tin-sulfide-thin-films-from-nanocolloids-prepared-by-pulsed-laser-ablation-in-liquid
#19
Jacob Johny, Selene Sepulveda-Guzman, Bindu Krishnan, David A Avellaneda, Josue A Aguilar Martinez, Sadasivan Shaji
Tin sulfide (SnS) nanoparticles were synthesized by pulsed laser ablation in liquid (PLAL) technique using an Nd:YAG laser operated at 532 nm. SnS thin films were deposited by spraying the colloidal suspension onto the heated substrates. The influence of different liquid media (dimethyl formamide and isopropyl alcohol) on the thin film properties were studied. Morphology, crystalline structure, and chemical composition of the nanoparticles were identified using transmission electron microscopy with energy dispersive X-ray analysis...
December 15, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27939245/evaluation-of-a-modified-cleaning-procedure-in-the-prevention-of-carbapenem-resistant-acinetobacter-baumannii-clonal-spread-in-a-burn-intensive-care-unit-using-a-high-sensitivity-luminometer
#20
B Casini, C Selvi, M L Cristina, M Totaro, A L Costa, P Valentini, S Barnini, A Baggiani, E Tagliaferri, G Privitera
BACKGROUND: Enhanced environmental cleaning practices are among the most accepted measures for controlling the spread of carbapenem-resistant Acinetobacter baumannii (CR-Ab). AIM: To evaluate the impact of heightened cleaning on an ongoing CR-Ab outbreak in a burn intensive care unit (BICU) of an Italian teaching hospital, where chlorhexidine-60% isopropyl alcohol was applied as a complementary disinfectant on high-touch surfaces. METHODS: Compliance with the microbial limit proposed for the BICU by AFNOR-NF-S90-351 (20 colony-forming units/100cm(2)) was assessed by plate count, and compared with the results obtained with intracellular adenosine triphosphate (ATP) detection...
January 2017: Journal of Hospital Infection
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