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Isopropyl alcohol

Gisele Façanha Diógenes Teixeira, Flávio Nogueira da Costa, Adriana Rolim Campos
CONTEXT: (-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. OBJECTIVE: To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent. MATERIALS AND METHODS: Acute corneal nociception was induced by the local application of hypertonic saline (5 M NaCl; 20 μL) to the corneal surface of Swiss mice (n = 8/group) 60 min after topical treatment with solutions or ointment containing BISA (50-200 mg/mL)...
December 2017: Pharmaceutical Biology
Guanghui Wu, David Selden, Anthony R Fooks, Ashley Banyard
Rabies virus is a notifiable pathogen that must be handled in high containment facilities where national and international guidelines apply. For the effective inactivation of rabies virus, a number of reagents were tested. Virkon S (1%) solution caused more than 4log reduction of rabies virus in culture medium supplemented with 10% foetal calf serum within 1min. Isopropyl alcohol (70%) treatment resulted in >3log reduction of rabies virus within 20s when applied at a ratio of 19:1, making it a suitable agent for surface decontamination whereas 70% ethanol was ineffective...
February 5, 2017: Journal of Virological Methods
P Tatarelli, I Lorenzi, I Caviglia, R A Sacco, D LA Masa, E Castagnola
INTRODUCTION: Hand decontamination with alcohol-based antiseptic agents is considered the best practise to reduce healthcare associated infections. We present a new method to monitor hand hygiene, introduced in a tertiary care pediatric hospital in Northern Italy, which estimates the mean number of daily hand decontamination procedures performed per patient. METHODS: The total amount of isopropyl alcohol and chlorhexidine solution supplied in a trimester to each hospital ward was put in relation with the number of hospitalization days, and expressed as litres/1000 hospitalization-days (World Health Organization standard method)...
December 2016: Journal of Preventive Medicine and Hygiene
Mitsuo Hinoue, Sumiyo Ishimatsu, Yukiko Fueta, Hajime Hori
OBJECTIVES: A new desorption method was investigated, which does not require toxic organic solvents. Efficient desorption of organic solvents from activated carbon was achieved with an ananionic surfactant solution, focusing on its washing and emulsion action. METHODS: Isopropyl alcohol (IPA) and methyl ethyl ketone (MEK) were used as test solvents. Lauryl benzene sulfonic acid sodium salt (LAS) and sodium dodecyl sulfate (SDS) were used as the surfactant. Activated carbon (100 mg) was placed in a vial and a predetermined amount of organic solvent was added...
January 28, 2017: Journal of Occupational Health
Kaveh Mohammad, Douglas J Thomson
A simple high frequency capacitance sensor with 180 aF sensitivity is designed for a wide range of microfluidic applications. The sensor is implemented utilizing differential ring oscillators operating at [Formula: see text] MHz with a differential signal at [Formula: see text] MHz. The sensor occupies [Formula: see text] cm × 2 cm on a printed circuit board. The sensor is tuned using two precision variable capacitors and has a full scale range of [Formula: see text] pF. The sensor was able to detect less than 1% Isopropyl Alcohol in DI water and to detect 15 μm polystyrene spheres flowing over 25 μm lines and spaces coplanar electrodes in a microfluidic channel...
January 23, 2017: IEEE Transactions on Biomedical Circuits and Systems
Byungil Hwang, Youngseo An, Hyangsook Lee, Eunha Lee, Stefan Becker, Yong-Hoon Kim, Hyoungsub Kim
There is an increasing demand in the flexible electronics industry for highly robust flexible/transparent conductors that can withstand high temperatures and corrosive environments. In this work, outstanding thermal and ambient stability is demonstrated for a highly transparent Ag nanowire electrode with a low electrical resistivity, by encapsulating it with an ultra-thin Al2O3 film (around 5.3 nm) via low-temperature (100 °C) atomic layer deposition. The Al2O3-encapsulated Ag nanowire (Al2O3/Ag) electrodes are stable even after annealing at 380 °C for 100 min and maintain their electrical and optical properties...
January 27, 2017: Scientific Reports
Jovanna Martínez, Juan H Macías, Virginia Arreguín, Jose A Álvarez, Alejandro E Macías, Juan L Mosqueda-Gómez
BACKGROUND: False-positive blood cultures can lead to unnecessary risks and misuse of antibiotics; to reduce rates of false-positives, it would be useful to determine whether use of an antiseptic with a prolonged effect is required. METHODS: Clinical study of efficacy (blinded and randomized) to compare the rate of blood culture contamination when skin antisepsis was performed with 70% isopropyl alcohol or 2% chlorhexidine gluconate in 70% isopropyl alcohol in 2 hospitals...
January 12, 2017: American Journal of Infection Control
Sagar Sopanrao Muley, Tanaji Nandgude, Sushilkumar Poddar
BACKGROUND: In the present study, Lansoprazole pellets were prepared employing a novel excipient Carboxymethyl tamarind kernel powder (CMTKP) using extrusion-spheronization technique. Pellet formulation was optimized for formulation parameters (concentration of microcrystalline cellulose, CMTKP, croscarmellose sodium and isopropyl alcohol). METHODS: Process parameters (speed and duration of spheronization) were optimized using factorial design. The pellets were evaluated for yield, bulk and tapped density, particle size, hardness, drug content, disintegration time and drug release...
January 13, 2017: Recent Patents on Drug Delivery & Formulation
Naira Carniel, Giovani L Zabot, Marshall Paliga, Marcelo L Mignoni, Marcio A Mazzuti, Wagner L Priamo, J V Oliveira, Marco Di Luccio, Marcus V Tres
The separation of Jatropha curcas oil from azeotropes of ethyl alcohol/n-hexane and isopropyl alcohol/n-hexane using ceramic membranes with different cut-offs (5, 10 and 20 kDa) is presented. The mass ratios of oil:azeotropes (O:S) studied were 1:3 for feeding pressures of 0.1, 0.2 and 0.3 MPa, and 1:1 for feeding pressure of 0.1 MPa. Isopropyl alcohol was the best solvent for the membranes conditioning to permeate n-hexane (240 kg/m2.h). In the separation of Jatropha curcas oil and azeotropes of solvents, both membranes showed oil retention and total flux decreases with time...
January 15, 2017: Environmental Technology
Giancarlo A Garcia, Christine V Nguyen, Marc A Yonkers, Jeremiah P Tao
PURPOSE: Baby shampoo is used as an alternative surgical skin preparation, but the evidence supporting its use is scarce with no descriptions of efficacy in the periocular region. The authors compare the efficacy of baby shampoo, povidone-iodine (PI, Betadine) and isopropyl alcohol (IA) in reducing eyelid skin bacterial load. METHODS: Prospective, randomized, comparative, and interventional trial. Bacterial load on adult, human eyelid skin was quantitated before and after cleansing with 1) dilute baby shampoo, 2) 10% PI, or 3) 70% IA...
January 6, 2017: Ophthalmic Plastic and Reconstructive Surgery
Xiaotu Liu, Gang Yu, Zhiguo Cao, Bin Wang, Jun Huang, Shubo Deng, Yujue Wang
This study surveyed occurrences and influencing factors of organophosphorus flame retardants (PFRs) on skin surface. Skin wipe samples from palms, back-of-hands and forearms of 30 adults were collected by using gauze pads soaked in isopropyl alcohol in Beijing, China. Tris(chloropropyl) phosphate isomers (∑TCPP), tris(2-chloroethyl) phosphate (TCEP) and triphenyl phosphate (TPHP) were the most abundant compounds with detection frequencies higher than 97%. ∑TCPP showed the highest mean level (4.6μg/m(2)), followed by TPHP (2...
October 28, 2016: Environment International
Chang Ho Yu, Bhupendra Patel, Marilou Palencia, Zhihua Tina Fan
A selective, sensitive, and accurate analytical method for the measurement of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in human serum, utilizing LC-MS/MS (liquid chromatography-tandem mass spectrometry), was developed and validated according to the Centers for Disease Control and Prevention (CDC) guidelines for biological sample analysis. Tests were conducted to determine the optimal analytical column, mobile phase composition and pH, gradient program, and cleaning procedure. The final analytical column selected for analysis was an extra densely bonded silica-packed reverse-phase column (Agilent XDB-C8, 3...
January 13, 2017: Journal of Chromatography. A
Jacob Johny, Selene Sepulveda-Guzman, Bindu Krishnan, David A Avellaneda, Josue A Aguilar Martinez, Sadasivan Shaji
Tin sulfide (SnS) nanoparticles were synthesized by pulsed laser ablation in liquid (PLAL) technique using an Nd:YAG laser operated at 532 nm. SnS thin films were deposited by spraying the colloidal suspension onto the heated substrates. The influence of different liquid media (dimethyl formamide and isopropyl alcohol) on the thin film properties were studied. Morphology, crystalline structure, and chemical composition of the nanoparticles were identified using transmission electron microscopy with energy dispersive X-ray analysis...
December 15, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
B Casini, C Selvi, M L Cristina, M Totaro, A L Costa, P Valentini, S Barnini, A Baggiani, E Tagliaferri, G Privitera
BACKGROUND: Enhanced environmental cleaning practices are among the most accepted measures for controlling the spread of carbapenem-resistant Acinetobacter baumannii (CR-Ab). AIM: To evaluate the impact of heightened cleaning on an ongoing CR-Ab outbreak in a burn intensive care unit (BICU) of an Italian teaching hospital, where chlorhexidine-60% isopropyl alcohol was applied as a complementary disinfectant on high-touch surfaces. METHODS: Compliance with the microbial limit proposed for the BICU by AFNOR-NF-S90-351 (20 colony-forming units/100cm(2)) was assessed by plate count, and compared with the results obtained with intracellular adenosine triphosphate (ATP) detection...
January 2017: Journal of Hospital Infection
Songita A Choudhury, Feng Xie, Paul A Dayton, Thomas R Porter
BACKGROUND: Commercially available microbubbles such as Definity contain octafluoropropane encapsulated in a lipid shell. This perfluorocarbon can be compressed into liquid nanodroplets at room temperatures and activated with transthoracic diagnostic ultrasound. The aim of this study was to determine the size range and acoustic characteristics of Definity nanodroplets (DNDs) compared with Definity microbubbles (DMBs). METHODS: An in vitro flow system was used with a diagnostic ultrasound transducer (S5-1, iE33)...
December 6, 2016: Journal of the American Society of Echocardiography
Choon Chiat Oh, Hazel H Oon, See Ket Ng, Shang Ian Tee, Anjali Jhingan, Wei-Sheng Chong
The term terra firma-forme dermatosis arises from the Latin phrase terra firma, meaning dry land (dirt), thus implying dirt-like dermatosis. The authors highlight five cases of patients with terra firma-forme dermatosis presenting to our dermatology center between 2012 and 2013. All patients presented to the dermatologist for persistent reticulated brown patches on the skin. These patients ranged in age from 6 to 22 years. All patients had tried various cleansing soaps and agents but were unable to remove the patches...
2016: Skinmed
Chen Han Shiau, Kuan Lun Pan, Sheng Jen Yu, Shaw Yi Yan, Moo Been Chang
No abstract text is available yet for this article.
November 10, 2016: Environmental Technology
Greyce Kelly Steinhorst Alcantara, Leandro Augusto Calixto, Luiz Alberto Beraldo de Moraes, Regina Helena Costa Queiroz, Anderson Rodrigo Moraes de Oliveira, Cristiane Masetto de Gaitani
Levetiracetam (LEV) is an antiepileptic drug that is clinically effective in generalized and partial epilepsy syndromes. The use of this drug has been increasing in clinical practice and intra- or -interindividual variability has been exhibited for special population. For this reason, bioanalytical methods are required for drug monitoring in biological matrices. So this work presents a dispersive liquid-liquid microextraction method followed by gas chromatography-mass spectrometry (DLLME-GC-MS) for LEV quantification in human plasma...
2016: Journal of Analytical Methods in Chemistry
Siti Noorhaniah Yusoh, Khatijah Aisha Yaacob
The optimization of etchant parameters in wet etching plays an important role in the fabrication of semiconductor devices. Wet etching of tetramethylammonium hydroxide (TMAH)/isopropyl alcohol (IPA) on silicon nanowires fabricated by AFM lithography is studied herein. TMAH (25 wt %) with different IPA concentrations (0, 10, 20, and 30 vol %) and etching time durations (30, 40, and 50 s) were investigated. The relationships between etching depth and width, and etching rate and surface roughness of silicon nanowires were characterized in detail using atomic force microscopy (AFM)...
2016: Beilstein Journal of Nanotechnology
Yuanying Fang, Zunhua Yang, Shankariah Gundeti, Jongkook Lee, Haeil Park
A series of GPR119 agonists based on a 5-nitropyrimidine scaffold bearing endo-azabicyclic substituents were synthesized and evaluated for their GPR119 agonistic activities. Most compounds exhibited much stronger EC50 values than that of oleoylethanolamide (OEA). Among them, derivatives from endo-azabicyclic alcohols displayed more potent GPR119 agonistic activities than compounds with endo-azabicyclic amines. Especially the optimized compounds (6, 7, 8, 12, 17) were shown to have potent biological activities and were identified as full agonists...
January 1, 2017: Bioorganic & Medicinal Chemistry
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