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Isopropyl alcohol

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https://www.readbyqxmd.com/read/28420285/dry-powders-for-the-inhalation-of-ciprofloxacin-or-levofloxacin-combined-with-a-mucolytic-agent-for-cystic-fibrosis-patients
#1
Yagmur Akdag Cayli, Selma Sahin, Francesca Buttini, Anna Giulia Balducci, Serena Montanari, Imran Vural, Levent Oner
OBJECTIVE: This study aimed to design and characterize an inhalable dry powder of ciprofloxacin or levofloxacin combined with the mucolytics acetylcysteine and dornase alfa for the management of pulmonary infections in patients with cystic fibrosis. METHODS: Ball milling, homogenization in isopropyl alcohol, and spray drying processes were used to prepare dry powders for inhalation. Physico-chemical characteristics of the dry powders were assessed via thermogravimetric analysis, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometry, and scanning electron microscopy...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28402896/biodegradation-of-isopropanol-and-acetone-under-denitrifying-conditions-by-thauera-sp-tk001-for-nitrate-mediated-microbially-enhanced-oil-recovery
#2
Tekle Tafese Fida, Fatma Gassara, Gerrit Voordouw
Amendment of reservoir fluid with injected substrates can enhance the growth and activity of microbes. The present study used isopropyl alcohol (IPA) or acetone to enhance the indigenous anaerobic nitrate-reducing bacterium Thauera sp. TK001. The strain was able to grow on IPA or acetone and nitrate. To monitor effects of strain TK001 on oil recovery, sand-packed columns containing heavy oil were flooded with minimal medium at atmospheric or high (400psi) pressure. Bioreactors were then inoculated with 0.5 pore volume (PV) of minimal medium containing Thauera sp...
March 30, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28399680/polyol-monoterpenes-isolated-from-chenopodium-ambrosioides
#3
Shu-Qun Hou, Yan-Hong Li, Xiang-Zhong Huang, Rong Li, Huai Lu, Kai Tian, Rong-Sheng Ruan, Yu-Kui Li
Phytochemical study on the 95% ethyl alcohol extract of stems of Chenopodium ambrosioides resulted in the isolation of two new polyol monoterpenes, 4-hydroxy-4(α or β)-isopropyl-2-methyl-2-cyclohexen-1-one (1) and 1-methyl-4β- isopropyl-1-cyclohexene-4α,5α,6α-triol (2), together with five known compounds, (1S,2S,3R,4S)-1-methyl-4-(propan-2-yl)cyclohexane-1,2,3,4-tetrol (3), (1R,2S,3S,4S)- 1,2,3,4-tetrahydroxy-p-menthane (4), (1R,2S)-3-p-menthen-1,2-diol (5), (1R,4S)-p- menth-2-en-1-ol (6) and 1,4-dihydroxy-p-menth-2-ene (7)...
April 12, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28396339/poppers-legal-highs-with-questionable-contents-a-case-series-of-poppers-maculopathy
#4
Rebecca Rewbury, Edward Hughes, Robert Purbrick, Stephen Prior, Mark Baron
BACKGROUND: Poppers are volatile alkyl nitrite compounds that are inhaled to enhance sexual experience and for their psychoactive effects. A less well-known side effect is foveal maculopathy, which has emerged following changes in their chemical composition. It is unclear if certain individuals are more susceptible to retinal damage or if there is a relationship between pattern of inhalation and brands used. METHODS: A case series of 12 patients presenting to Sussex Eye Hospital, Brighton, with poppers-related visual impairment...
April 10, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379643/integrating-in-vitro-modeling-and-in-vivo-approaches-to-investigate-warfarin-bioequivalence
#5
Xinyuan Zhang, Hong Wen, Jianghong Fan, Bradley Vince, Tonglei Li, Wei Gao, Minori Kinjo, Jill Brown, Wanjie Sun, Wenlei Jiang, Robert Lionberger
We demonstrate the use of modeling and simulation to investigate bioequivalence concerns raised about generic warfarin products. To test the hypothesis that the loss of isopropyl alcohol and slow dissolution in acidic pH have significant impact on the pharmacokinetics of warfarin sodium tablets, we conducted physiologically based pharmacokinetic absorption modeling and simulation using formulation factors, or in vitro dissolution profiles as input parameters. Sensitivity analyses indicated that warfarin pharmacokinetics was not sensitive to solubility, particle size and density, or dissolution rate in pH 4...
April 5, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28345701/the-effect-of-natural-iron-oxide-and-oxalic-acid-on-the-photocatalytic-degradation-of-isoproturon-a-kinetics-and-analytical-study
#6
H Boucheloukh, W Remache, F Parrino, T Sehili, H Mechakra
The photocatalytic degradation of isoproturon, a persistent toxic herbicide, was investigated in the presence of natural iron oxide and oxalic acid and under UV irradiation. The influence of the relevant parameters such as the pH and the iron oxide and oxalic acid concentrations has been studied. The presence of natural iron oxide and oxalic acid in the system effectively allow the degradation of isoproturon, whereas the presence of t-butyl alcohol adversely affects the phototransformation of the target pollutant, thus indicating that an OH radical initiated the degradation mechanism...
March 27, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28341597/effect-of-isopropyl-myristate-on-transdermal-permeation-of-testosterone-from-carbopol-gel
#7
Ahmed S Zidan, Nahid Kamal, Alaadin Alayoubi, Mark Seggel, Sarah Ibrahim, Ziyaur Rahman, Celia Cruz, Muhammad Ashraf
The objective of the current study was to investigate the effect of isopropyl myristate (IPM) on the in vitro permeation of Testosterone through human cadaver skin from carbopol- gels. Six Testosterone gel formulations were prepared employing different IPM contents of 0, 0.4, 0.7, 1, 2 and 3%. The gels were characterized for drug permeation, matrix morphology, pH, kinetics of ethanol evaporation and viscosity. Mass balance studies were performed to estimate testosterone distribution among the compartments of diffusion cells...
March 21, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28336842/sers-based-flavonoid-detection-using-ethylenediamine-%C3%AE-cyclodextrin-as-a-capturing-ligand
#8
Jae Min Choi, Eunil Hahm, Kyeonghui Park, Daham Jeong, Won-Yeop Rho, Jaehi Kim, Dae Hong Jeong, Yoon-Sik Lee, Sung Ho Jhang, Hyun Jong Chung, Eunae Cho, Jae-Hyuk Yu, Bong-Hyun Jun, Seunho Jung
Ethylenediamine-modified β-cyclodextrin (Et-β-CD) was immobilized on aggregated silver nanoparticle (NP)-embedded silica NPs (SiO₂@Ag@Et-β-CD NPs) for the effective detection of flavonoids. Silica NPs were used as the template for embedding silver NPs to create hot spots and enhance surface-enhanced Raman scattering (SERS) signals. Et-β-CD was immobilized on Ag NPs to capture flavonoids via host-guest inclusion complex formation, as indicated by enhanced ultraviolet absorption spectra. The resulting SiO₂@Ag@Et-β-CD NPs were used as the SERS substrate for detecting flavonoids, such as hesperetin, naringenin, quercetin, and luteolin...
January 6, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28321695/solubility-and-thermodynamic-analysis-of-antihypertensive-agent-nitrendipine-in-different-pure-solvents-at-the-temperature-range-of-298-15-to-318-15%C3%A2-k
#9
Abdul Ahad, Faiyaz Shakeel, Mohammad Raish, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea
The aim of the present study was to ascertain the solubility of nitrendipine (NP), an antihypertensive drug in six different pure solvents such as water, ethyl acetate (EA), ethanol, isopropyl alcohol (IPA), polyethylene glycol-400 (PEG-400), and Transcutol at temperature from 298.15 to 318.15 K under atmospheric pressure (p) of 0.1 MPa. Experimental solubility data of NP was fitted with Apelblat and ideal models. The mole fraction solubility of NP was found maximum in PEG-400 (6.85 × 10(-2) at 318.15 K) followed by Transcutol (4...
March 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28301624/photodynamic-therapy-effectively-treats-actinic-keratoses-without-pre-illumination-incubation-time
#10
Jessica Gandy, Brian Labadie, Dina Bierman, Christopher Zachary
<p>BACKGROUND: Actinic keratoses (AKs) are dysplastic lesions of the epidermis that have the potential to progress to non-melanoma skin cancers (NMSC). Traditional photodynamic therapy (PDT) requires a pre-illumination incubation time, which adds to overall in-office time and has been linked to pain. Our group has found a novel protocol to effectively treat AKs with PDT that eliminates the pre-illumination incubation period and uses 2 back-to-back cycles of 16 minute 40 seconds.</p> <p>METHODS: The patient was prepped with soapy water and isopropyl alcohol, and thick AKs were descaled with a curette...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28267322/stereorigid-osso-type-group-4-metal-complexes-in-the-ring-opening-polymerization-of-rac-lactide
#11
Rosita Lapenta, Antonio Buonerba, Assunta De Nisi, Magda Monari, Alfonso Grassi, Stefano Milione, Carmine Capacchione
The synthesis and characterization of a series of group 4 metal complexes of general formula {OSSOX}M(OR)2 (X = R = (t)Bu, M = Zr (1); X = cumyl, M = Zr, R = (t)Bu (2); X = cumyl, M = Ti, R = (i)Pr (4); X = cumyl, M = Hf, R = (t)Bu (5)) and {OSSOX}2Zr (X = Cl (3)) supported by o-phenylene-bridged bis(phenolato) ligands (OSSOtBu-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-di-tert-butyphenol); OSSOCum-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-bis(2-phenylpropan-2-yl)phenol); OSSOCl-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-dichlorophenol)) are described herein...
March 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28253227/reported-adverse-health-effects-in-children-from-ingestion-of-alcohol-based-hand-sanitizers-united-states-2011-2014
#12
Cynthia Santos, Stephanie Kieszak, Alice Wang, Royal Law, Joshua Schier, Amy Wolkin
Hand sanitizers are effective and inexpensive products that can reduce microorganisms on the skin, but ingestion or improper use can be associated with health risks. Many hand sanitizers contain up to 60%-95% ethanol or isopropyl alcohol by volume, and are often combined with scents that might be appealing to young children. Recent reports have identified serious consequences, including apnea, acidosis, and coma in young children who swallowed alcohol-based (alcohol) hand sanitizer (1-3). Poison control centers collect data on intentional and unintentional exposures to hand sanitizer solutions resulting from various routes of exposure, including ingestion, inhalation, and dermal and ocular exposures...
March 3, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28241955/clinical-issues-march-2017
#13
Sharon A Van Wicklin
Using one flexible endoscope for an upper and lower gastrointestinal (GI) endoscopy procedure Key words: flexible endoscope, esophagogastroduodenoscopy, colonoscopy, enteroscope, risk assessment. Enhanced methods for processing flexible duodenoscopes Key words: flexible duodenoscopes, liquid chemical sterilization, ethylene oxide sterilization, low-temperature sterilization, risk assessment. Modification of the Spaulding classification Key words: Spaulding classification, critical items, semicritical items, mucous membranes, risk assessment...
March 2017: AORN Journal
https://www.readbyqxmd.com/read/28239393/thermo-sensitive-polymer-nanospheres-as-a-smart-plugging-agent-for-shale-gas-drilling-operations
#14
Wei-Ji Wang, Zheng-Song Qiu, Han-Yi Zhong, Wei-An Huang, Wen-Hao Dai
Emulsifier-free poly(methyl methacrylate-styrene) [P(MMA-St)] nanospheres with an average particle size of 100 nm were synthesized in an isopropyl alcohol-water medium by a solvothermal method. Then, through radical graft copolymerization of thermo-sensitive monomer N-isopropylacrylamide (NIPAm) and hydrophilic monomer acrylic acid (AA) onto the surface of P(MMA-St) nanospheres at 80 °C, a series of thermo-sensitive polymer nanospheres, named SD-SEAL with different lower critical solution temperatures (LCST), were prepared by adjusting the mole ratio of NIPAm to AA...
2017: Petroleum Science
https://www.readbyqxmd.com/read/28193100/corneal-antinociceptive-effect-of-%C3%AE-bisabolol
#15
COMPARATIVE STUDY
Gisele Façanha Diógenes Teixeira, Flávio Nogueira da Costa, Adriana Rolim Campos
CONTEXT: (-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. OBJECTIVE: To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent. MATERIALS AND METHODS: Acute corneal nociception was induced by the local application of hypertonic saline (5 M NaCl; 20 μL) to the corneal surface of Swiss mice (n = 8/group) 60 min after topical treatment with solutions or ointment containing BISA (50-200 mg/mL)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28174074/inactivation-of-rabies-virus
#16
Guanghui Wu, David Selden, Anthony R Fooks, Ashley Banyard
Rabies virus is a notifiable pathogen that must be handled in high containment facilities where national and international guidelines apply. For the effective inactivation of rabies virus, a number of reagents were tested. Virkon S (1%) solution caused more than 4log reduction of rabies virus in culture medium supplemented with 10% foetal calf serum within 1min. Isopropyl alcohol (70%) treatment resulted in >3log reduction of rabies virus within 20s when applied at a ratio of 19:1, making it a suitable agent for surface decontamination whereas 70% ethanol was ineffective...
May 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28167854/estimation-of-mean-number-of-daily-hand-hygiene-procedures-per-patient-can-represent-an-effective-and-easy-understandable-method-to-evaluate-adherence-experience-in-a-tertiary-care-pediatric-hospital-of-northern-italy
#17
P Tatarelli, I Lorenzi, I Caviglia, R A Sacco, D LA Masa, E Castagnola
INTRODUCTION: Hand decontamination with alcohol-based antiseptic agents is considered the best practise to reduce healthcare associated infections. We present a new method to monitor hand hygiene, introduced in a tertiary care pediatric hospital in Northern Italy, which estimates the mean number of daily hand decontamination procedures performed per patient. METHODS: The total amount of isopropyl alcohol and chlorhexidine solution supplied in a trimester to each hospital ward was put in relation with the number of hospitalization days, and expressed as litres/1000 hospitalization-days (World Health Organization standard method)...
December 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28132972/a-new-desorption-method-for-removing-organic-solvents-from-activated-carbon-using-surfactant
#18
Mitsuo Hinoue, Sumiyo Ishimatsu, Yukiko Fueta, Hajime Hori
OBJECTIVES: A new desorption method was investigated, which does not require toxic organic solvents. Efficient desorption of organic solvents from activated carbon was achieved with an ananionic surfactant solution, focusing on its washing and emulsion action. METHODS: Isopropyl alcohol (IPA) and methyl ethyl ketone (MEK) were used as test solvents. Lauryl benzene sulfonic acid sodium salt (LAS) and sodium dodecyl sulfate (SDS) were used as the surfactant. Activated carbon (100 mg) was placed in a vial and a predetermined amount of organic solvent was added...
March 28, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28129183/differential-ring-oscillator-based-capacitance-sensor-for-microfluidic-applications
#19
Kaveh Mohammad, Douglas J Thomson
A simple high frequency capacitance sensor with 180 aF sensitivity is designed for a wide range of microfluidic applications. The sensor is implemented utilizing differential ring oscillators operating at [Formula: see text] MHz with a differential signal at [Formula: see text] MHz. The sensor occupies [Formula: see text] cm × 2 cm on a printed circuit board. The sensor is tuned using two precision variable capacitors and has a full scale range of [Formula: see text] pF. The sensor was able to detect less than 1% Isopropyl Alcohol in DI water and to detect 15 μm polystyrene spheres flowing over 25 μm lines and spaces coplanar electrodes in a microfluidic channel...
April 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28128218/highly-flexible-and-transparent-ag-nanowire-electrode-encapsulated-with-ultra-thin-al2o3-thermal-ambient-and-mechanical-stabilities
#20
Byungil Hwang, Youngseo An, Hyangsook Lee, Eunha Lee, Stefan Becker, Yong-Hoon Kim, Hyoungsub Kim
There is an increasing demand in the flexible electronics industry for highly robust flexible/transparent conductors that can withstand high temperatures and corrosive environments. In this work, outstanding thermal and ambient stability is demonstrated for a highly transparent Ag nanowire electrode with a low electrical resistivity, by encapsulating it with an ultra-thin Al2O3 film (around 5.3 nm) via low-temperature (100 °C) atomic layer deposition. The Al2O3-encapsulated Ag nanowire (Al2O3/Ag) electrodes are stable even after annealing at 380 °C for 100 min and maintain their electrical and optical properties...
January 27, 2017: Scientific Reports
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