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https://www.readbyqxmd.com/read/28523996/micro-rnas-exercise-and-cellular-plasticity-in-humans-the-impact-of-dietary-factors-and-hypoxia
#1
Timothée Watier, Anthony Mj Sanchez
Physical exercise is a stress that modulates a plethora of cellular mechanisms to promote morphological and metabolic adaptations. Substantial efforts have been made to better understand the modulation of pathways involved in cell plasticity during exercise, but human explorations may be limited because invasive procedures are often required. In recent years, minimally invasive methods for the analysis of microRNAs (miRNAs) modulation in response to exercise have been developed. miRNAs are small molecules that belong to a family of non-coding RNAs...
May 19, 2017: MicroRNA
https://www.readbyqxmd.com/read/28515832/a-low-dose-caffeine-and-carbohydrate-supplement-does-not-improve-athletic-performance-during-volleyball-competition
#2
David R Pfeifer, Kelsey M Arvin, Courtney N Herschberger, Nicholas J Haynes, Matthew S Renfrow
Dietary supplements are widely used to enhance sport performance and the combination of carbohydrate and caffeine (CHO+CAF) has yielded particularly high performance gains. Though the effects of a CHO+CAF supplement have been studied in a laboratory environment, little research exists on the effects of supplementation during competition. Therefore, the purpose of this study was to determine the effects of a CHO+CAF supplement on athletic performance in competition. Eight female collegiate volleyball players completed three testing sessions under three different conditions separated by approximately one week each: CHO+CAF supplement, placebo (PBO), and control (CTL) using a randomized, cross-over design...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28513179/consumption-of-watermelon-juice-enriched-in-l-citrulline-and-pomegranate-ellagitannins-enhanced-metabolism-during-physical-exercise
#3
Ascension Martinez-Sanchez, Fernando Alacid, Jacobo A Rubio-Arias, Bárbara Fernandez-Lobato, Domingo J Ramos-Campo, Encarna Aguayo
L-citrulline is a non-essential amino acid precursor of arginine and indirectly a precursor of nitric oxide (NO), which is a vasodilator and increases mitochondrial respiration. On the other hand, the antioxidant pomegranate ellagitannins are precursors of urolithin A, which has been associated with mitophagy and increased muscle function. To elucidate if a single dose of watermelon enrichment with these compounds have a positive effect after a high intensity exercise (8 sets of 8 repetitions of half squat exercise), a double-blind randomized crossover in vivo study was performed in healthy male subjects (n=19)...
May 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28500767/metformin-for-high-altitude-performance
#4
Martin Burtscher
Metformin has been introduced for treatment of type 2 diabetes but may also have ergogenic properties at high altitude by improving muscle glycogen repletion. However, very little information is available on potential risks associated with the (mis)use of metformin by healthy people. This article is protected by copyright. All rights reserved.
May 13, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28486332/short-term-heat-acclimation-and-precooling-independently-and-combined-improve-5-km-running-performance-in-the-heat
#5
C A James, A J Richardson, A G B Willmott, P W Watt, O R Gibson, N S Maxwell
Following heat acclimation (HA), endurance running performance remains impaired in hot vs temperate conditions. Combining HA with precooling demonstrates no additive benefit in intermittent sprint, or continuous cycling exercise protocols, during which heat strain may be less severe compared to endurance running. This study investigated the effect of short-term heat acclimation (STHA) combined with mixed-methods precooling, on endurance running performance and directly compared precooling and HA. Nine amateur trained runners completed 5 km treadmill time trials in the heat (32°C, 60% RH) under four conditions; no intervention (CON), precooling (PC), short-term heat acclimation (5 days - HA) and short-term heat acclimation with precooling (HA+PC)...
May 5, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28481224/intermittent-glucocorticoid-steroid-dosing-enhances-muscle-repair-without-eliciting-muscle-atrophy
#6
Mattia Quattrocelli, David Y Barefield, James L Warner, Andy H Vo, Michele Hadhazy, Judy U Earley, Alexis R Demonbreun, Elizabeth M McNally
Glucocorticoid steroids such as prednisone are prescribed for chronic muscle conditions such as Duchenne muscular dystrophy, where their use is associated with prolonged ambulation. The positive effects of chronic steroid treatment in muscular dystrophy are paradoxical because these steroids are also known to trigger muscle atrophy. Chronic steroid use usually involves once-daily dosing, although weekly dosing in children has been suggested for its reduced side effects on behavior. In this work, we tested steroid dosing in mice and found that a single pulse of glucocorticoid steroids improved sarcolemmal repair through increased expression of annexins A1 and A6, which mediate myofiber repair...
May 8, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28480382/the-effect-of-caffeine-supplementation-on-trained-individuals-subjected-to-maximal-treadmill-test
#7
Viviane Martins Mana Salicio, Carlos Alexandre Fett, Marcos Adriano Salicio, Camila Fernanda Costa Cunha Moraes Brandäo, Luiz Fabrizio Stoppiglia, Waléria Christiane Rezende Fett, And Clovis Botelho
BACKGROUND: Intense physical training increases oxidative stress and inflammation, resulting into muscle and cellular damage. The aim of this study was to analyze the effect of caffeine supplementation on trained young individuals subjected to two treadmill maximal tests. MATERIALS AND METHODS: It was a double-blind and crossover study comprising 24 active individuals within the age group 18-30 years. The comparisons were conducted: the effect of exercise (week 1 x 2) and caffeine intake (GC x GP) on thiobarbituric acid (TBARS), interleukin 6 (IL-6), interleukin 10 (IL-10) and superoxide dismutase (SOD) variables during pre-exercise time (30 min...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28479951/acute-effects-of-24-h-sleep-deprivation-on-salivary-cortisol-and-testosterone-concentrations-and-testosterone-to-cortisol-ratio-following-supplementation-with-caffeine-or-placebo
#8
Ciaran Mc Donald, Joss Moore, Alan McIntyre, Kevin Carmody, Bernard Donne
Caffeine has become a popular ergogenic aid amongst athletes and usage to improve athletic performance has been well documented. The effect of caffeine on anabolic and catabolic hormones in a sleep-deprived s tate has had little investigation to date. The purpose of the current study was to investigate the potential of caffeine to offset the effects, if any, of short-term sleep deprivation and exercise on an athlete's testosterone and cortisol concentrations via salivary technique. Eleven competitive male athletes volunteered to be part of this prospective double-blinded study...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28467859/the-novel-combination-of-theophylline-and-bambuterol-as-a-potential-treatment-of-hypoxemia-in-humans
#9
Trond-Eirik Strand, Hasse Khiabani-Zare, Alina Boico, Daniel R Radiloff, Yulin Zhao, Karyn Hamilton, Uwe Christians, Jelena Klawitter, Robert J Noveck, Claude A Piantadosi, Christopher Bell, David C Irwin, Thies Schroeder
Hypoxemia can be life-threatening both, acutely and chronically. Because hypoxemia causes vascular dysregulation that further restricts oxygen availability to tissue, it can be pharmacologically addressed. We hypothesized that theophylline can be safely combined with the β2 adrenergic vasodilator bambuterol to improve oxygen availability in hypoxemic patients. Ergogenicity and hemodynamic effects of bambuterol and theophylline were measured in rats under hypobaric and normobaric hypoxia (12% O2). Feasibility in humans was assessed using randomized, double-blind testing of the influence of combined slow-release theophylline (300 mg) and bambuterol (20mg) on adverse events (AEs), plasma K+, pulse, blood pressure, and drug interaction...
May 3, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28465675/dietary-thiols-in-exercise-oxidative-stress-defence-exercise-performance-and-adaptation
#10
REVIEW
Yanita McLeay, Stephen Stannard, Stuart Houltham, Carlene Starck
Endurance athletes are susceptible to cellular damage initiated by excessive levels of aerobic exercise-produced reactive oxygen species (ROS). Whilst ROS can contribute to the onset of fatigue, there is increasing evidence that they play a crucial role in exercise adaptations. The use of antioxidant supplements such as vitamin C and E in athletes is common; however, their ability to enhance performance and facilitate recovery is controversial, with many studies suggesting a blunting of training adaptations with supplementation...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28458274/supplementation-with-hualian-no-4-wild-bitter-gourd-momordica-charantia-linn-var-abbreviata-ser-extract-increases-anti-fatigue-activities-and-enhances-exercise-performance-in-mice
#11
Chien-Yu Hsiao, Yi-Ming Chen, Yi-Ju Hsu, Chi-Chang Huang, Hsin-Ching Sung, Sheng-Shih Chen
Hualian No. 4 wild bitter gourd (WBG) is a specific vegetable cultivated by the Hualien District Agricultural Research and Extension Station in Taiwan. WBG is commonly consumed as a vegetable and used as a popular folk medicine. However, few studies have demonstrated the effects of WBG supplementation on exercise performance, physical fatigue and the biochemical profile. The purpose of this study was to evaluate the potential beneficial effects of WBG extract on fatigue and ergogenic functions following physiological challenge...
May 1, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28445231/the-effects-of-multi-day-vs-single-pre-exercise-nitrate-supplement-dosing-on-simulated-cycling-time-trial-performance-and-skeletal-muscle-oxygenation
#12
Edward Jo, Michelle Fischer, Alexandra T Auslander, Alan Beigarten, Bruce Daggy, Ken Hansen, Lisa Kessler, Adam Osmond, Hong Wang, Rachel Wes
A transient augmentation in the metabolic efficiency of skeletal muscle is the purported basis for dietary nitrate supplementation amongst competitive and recreational athletes alike. Previous studies support the ergogenic effects of nitrate supplementation as findings indicated improved microvascular blood flow, exercise economy, and performance with relatively short-term supplementation. As with most ergogenic aids, the optimum duration of supplementation prior to performance or competition, i.e. loading phase, is a critical determinant for efficacy...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28429998/the-efficacy-of-a-pre-workout-vegan-supplement-on-high-intensity-cycling-performance-in-healthy-college-aged-males
#13
Gabrielle Gallien, David Bellar, Greggory R Davis
There is a limited supply of sport nutrition supplements currently available for vegan or vegetarian athletes. In addition, the efficacy of a vegan or vegetarian pre-workout supplement that does not contain any processed ingredients or stimulants is currently unknown. The purpose of the current study was to examine the effects of an unprocessed vegan pre-workout supplement on high-intensity cycling performance. Participants completed three separate cycling trials following the consumption of a vegan pre-workout supplement, an isocaloric processed supplement, or a zero-calorie placebo supplement...
November 2, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28426517/effects-of-betaine-supplementation-on-muscle-strength-and-power-a-systematic-review
#14
Ahmed Ismaeel
Betaine has recently gotten much attention for its potential role as an ergogenic aid and has become a common ingredient in peri-workout dietary supplements. The purpose of this systematic review of the literature was to investigate the effects of betaine supplementation on muscular strength and power. A computerized literature search of 3 databases (PubMed, MEDLINE, and Scopus) was performed. Included in the review were randomized controlled trials that measured muscle strength, power, and/or endurance in healthy participants...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28422520/low-level-laser-therapy-improves-performance-and-reduces-fatigue-in-competitive-cyclists
#15
Fábio J Lanferdini, Rodrigo R Bini, Bruno M Baroni, Kelli D Klein, Felipe P Carpes, Marco A Vaz
Evidence supports that low-level laser therapy (LLLT) minimizes fatigue effects on muscle performance. However, the ideal LLLT dosage to improve athletes' performance during sports activities, such as cycling, is still unclear. Therefore, the goal of this study was to investigate the effects of different LLLT dosages on cyclists' performance in time-to-exhaustion tests. In addition, we looked at the effects of LLLT on the frequency content of the EMG signals to assess fatigue mechanisms. Twenty male competitive cyclists participated in a crossover, randomized, double-blind and placebo-controlled trial...
April 19, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28394459/ergogenic-properties-of-metformin-in-simulated-high-altitude
#16
Rebecca L Scalzo, Hunter L Paris, Scott E Binns, Janelle L Davis, Joseph W Beals, Christopher L Melby, Gary J Luckasen, Matthew S Hickey, Benjamin F Miller, Karyn L Hamilton, Christopher Bell
Metformin augments glucose/glycogen regulation and may acutely promote fatigue resistance during high-intensity exercise. In hypobaric environments, such as high altitude, the important contribution of carbohydrates to physiological function is accentuated as glucose/glycogen dependence is increased. Because hypoxia/hypobaria decreases insulin sensitivity, replenishing skeletal muscle glycogen in high altitude becomes challenging and subsequent physical performance may be compromised. We hypothesized that in conditions where glycogen repletion was critical to physical outcomes, metformin would attenuate hypoxia-mediated decrements in exercise performance...
April 10, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28360825/ingestion-of-oxygenated-water-enhances-lactate-clearance-kinetics-in-trained-runners
#17
Neil Fleming, Jeremiah Vaughan, Matthew Feeback
BACKGROUND: Drinks with higher dissolved oxygen concentrations have in recent times gained popularity as a potential ergogenic aid, despite a lack of evidence regarding their efficacy. The aim of this study was to assess effects of ingestion of an oxygen supplement (OS) on exercise performance and post-exercise recovery in a group of trained runners. METHODS: Trained male runners (n = 25, mean ± SD; age 23 ± 6 years, mass 70 ± 9 kg, BMI 21.9 ± 2...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28349727/six-weeks-of-%C3%AE-alanine-supplementation-did-not-enhance-repeated-sprint-ability-or-technical-performances-in-young-elite-basketball-players
#18
Fabio Milioni, Paulo E Redkva, Fabio A Barbieri, Alessandro M Zagatto
Supplementation with β-alanine plays an important role as a precursor of carnosine, the most effective intramuscular buffer, and has been seen as a potential ergogenic aid, especially for high-intensity modalities such as basketball. Thus, the aim of the present study was to investigate the effects of 6 weeks of β-alanine supplementation on repeated sprint ability (RSA) and technical performances in young elite Brazilian basketball players. In total, 27 young basketball players (17±1 years) were randomized into a β-alanine group (Gβ - 6...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28346571/is-the-ergogenicity-of-caffeine-affected-by-increasing-age-the-direct-effect-of-a-physiological-concentration-of-caffeine-on-the-power-output-of-maximally-stimulated-edl-and-diaphragm-muscle-isolated-from-the-mouse
#19
J Tallis, R S James, V M Cox, M J Duncan
INTRODUCTION: Caffeine is a well-established performance enhancing nutritional supplement in a young healthy population, however far less is known about how its ergogenicity is affected by increasing age. A recent review has highlighted the value of studies examining the direct effect of caffeine on isolated skeletal muscle contractility, but the present work is the first to assess the direct effect of 70µM caffeine (physiological maximum) on the maximal power output of isolated mammalian muscle from an age range representing developmental to early ageing...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28329785/beet-root-juice-an-ergogenic-aid-for-exercise-and-the-aging-brain
#20
Meredith Petrie, W Jack Rejeski, Swati Basu, Paul J Laurienti, Anthony P Marsh, James L Norris, Daniel B Kim-Shapiro, Jonathan H Burdette
Background: Exercise has positive neuroplastic effects on the aging brain. It has also been shown that ingestion of beet root juice (BRJ) increases blood flow to the brain and enhances exercise performance. Here, we examined whether there are synergistic effects of BRJ and exercise on neuroplasticity in the aging brain. Methods: Peak metabolic equivalent (MET) capacity and resting-state magnetic resonance imaging functional brain network organization are reported on 26 older (mean age = 65...
November 9, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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