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nanoparticles uptake

Qingfu Ban, Jie Kong, Yinglai Hou, Jianxin Chen, Wen Sun, Xiaofei Zhang, Si Wu
We demonstrated an unconventional polymerization route to synthesize hydrophilic fluorescent organic nanoparticles (FONs) for multicolor cellular bioimaging in this contribution. Actually, it benefits from our unexpected discovery of a rapid polymerization reaction between 1, 6-hexanediol dipropiolate and 2, 4, 6-triazide-1, 3, 5-triazine under the catalysis of N, N, N', N", N"-pentamethyldiethylenetriamine (PMDETA). Interestingly, the 2, 4, 6-triazide-1, 3, 5-triazine and PMDETA system can also induce rapid free radical polymerization at room temperature...
April 18, 2018: Chemistry, An Asian Journal
Jiao Zhai, Yanwei Jia, Lina Zhao, Qing Yuan, Fuping Gao, Xiangchun Zhang, Pengju Cai, Liang Gao, Juanjuan Guo, Shuhong Yi, Zhifang Chai, Yuliang Zhao, Xueyun Gao
We reported two Au clusters with precisely controlled molecular size (Au5Peptide3 and Au22Peptide10) showing different anti-tumor effects. In vitro, both Au5Peptide3 and Au22Peptide10 were well taken up by human nasopharyngeal cancer cells (CNE1 cells). However, only Au5Peptide3 significantly induced CNE1 cell apoptosis. Further studies showed that CNE1 cells took up Au5Peptide3 (1.98*10-15 mol/cell) and 9% of them entered mitochondria (0.186*10-15 mol/cell). As a comparison, the uptake of Au22Peptide10 was only half the amount of Au5Peptide3 (1...
April 18, 2018: ACS Nano
Mengyu Zhang, Mingxing Zhang, Jing Wang, Qingqing Cai, Ran Zhao, Yi Yu, Haiyan Tai, Xiaoyan Zhang, Congjian Xu
BACKGROUND: The development of nanoparticle drug delivery systems with targeted ligands has the potential to increase treatment efficiency in ovarian cancer. METHODS: We developed a 21-amino acid peptide, YTRDLVYGDPARPGIQGTGTF (L-FP21) conjugated to polyethylenimine (PEI) and methoxy polyethylene glycol (mPEG) to prepare a nanoparticle drug vehicle to target follicle-stimulating hormone receptor (FSHR) in ovarian cancer. At the same time, we optimized the ligand of the nanoparticle vehicle using D-peptides, which consist of D-amino acids (D-FP21)...
November 2018: Drug Delivery
Tadahiro Yokosawa, Eric Prestat, Robert Polly, Muriel Bouby, Kathy Dardenne, Nicolas Finck, Sarah J Haigh, Melissa A Denecke, Horst Geckeis
Transformation products of two-line ferrihydrite associated with Lu(III) were studied after 12 years of aging using aberration-corrected high-angle annular dark field scanning transmission electron microscopy (HAADF-STEM), high-efficiency energy-dispersive X-ray spectroscopy (EDXS), and density functional theory (DFT). The transformation products consisted of hematite nanoparticles with overgrown goethite needles. High-efficiency STEM-EDXS revealed that Lu is only associated with goethite needles, and atomic-resolution HAADF-STEM reveals structural incorporation of Lu within goethite, partially replacing structural Fe sites...
April 18, 2018: Environmental Science and Pollution Research International
Rajendra Aluri, Sonashree Saxena, Dheeraj Chandra Joshi, Manickam Jayakannan
Multi-stimuli-responsive L-tyrosine based amphiphilic poly(ester-urethane)s nano-carriers were designed and developed, for the first time, to administrate anticancer drugs at cancer tissue environment via thermo-responsiveness and lysosomal enzymatic-biodegradation from single polymer platform. For this purpose, multifunctional L-tyrosine monomer was tailor-made with PEG-lated side chain at the phenolic position along with urethane and carboxylic ester functionalities. Under melt dual ester-urethane polycondensation, the tyrosine-monomer reacted with diols to produce high molecular weight amphiphilic poly(ester-urethane)s...
April 17, 2018: Biomacromolecules
Jianhong Liao, Haoran Zheng, Rui Hu, Jun Cao, Xuan Wei, Dan Li, Hua Zheng, Yihua Yin
In this study, a series of amphiphilic polymeric prodrugs (Azido-functionalized hyaluronan-triazole-imine-doxorubicin, HAimine-DOX) were designed and synthesized by the "Click" reaction with a remarkable grafting ratio of DOX. Nanoparticles with a core-shell structure can be obtained by self-assembling in aqueous media, which exhibited a particle size of 137-170 nm. Moreover, the HA-imine-DOX nanoparticles exhibited good stability in vitro, and the drug release was obviously mediated by the pH gradient...
March 1, 2018: Journal of Biomedical Nanotechnology
Mangmang Sang, Zhongtao Zhang, Fulei Liu, Lejian Hu, Lingchao Li, Li Chen, Feng Feng, Wenyuan Liu, Wei Qu
A novel multifunctional hyaluronic acid-decorated redox-responsive magnetic complex micelle (HA/CSO-SS-Hex/Fe3O4/PTX) based on a reducible hexadecanol-modified chitosan oligosaccharide polymer micelle (CSO-SS-Hex) coated with hyaluronic acid (HA) and loaded with paclitaxel (PTX) Fe3O4 nanoparticles is developed. HA is coated onto the surface of micelles via electrostatic absorption and acts as a targeting ligand for CD44 over expression in many tumor cells. A CSO-SS-Hex polymer micelle was used for PTX incorporation and GSH-triggered intracellular release...
March 1, 2018: Journal of Biomedical Nanotechnology
S Ichikawa, N Shimokawa, M Takagi, Y Kitayama, T Takeuchi
Size-dependent uptake behaviors of electrically neutral amphipathic polymeric nanoparticles in cell-sized liposomes and living cells were investigated. Kinetic analyses and the particle size distribution suggested a size-dependent penetration mechanism (size threshold: 3.1 nm). The definite size-dependent uptake provides a new insight into the interactions between nanomaterials and living cells.
April 17, 2018: Chemical Communications: Chem Comm
Zi-Wei Jing, Min Luo, Yi-Yang Jia, Chen Li, Si-Yuan Zhou, Qi-Bing Mei, Bang-Le Zhang
The amoxicillin-UCCs-2/TPP nanoparticles constructed with ureido-modified chitosan derivative UCCs-2 and sodium tripolyphosphate (TPP) played an important role to deliver drug to achieve more efficacious and specific eradication of Helicobacterpylori (H. pylori) in vitro. In this study, the anti-H. pylori effectiveness in vivo and uptake mechanism was investigated in details, including the effect of temperature, pH values and the addition of competitive substrate urea on uptake. Compared with unmodified nanoparticles, a more efficacious and specific anti-H...
April 13, 2018: International Journal of Biological Macromolecules
Hiruni Harischandra, Wang Yuan, Hannah J Loghry, Mostafa Zamanian, Michael J Kimber
The filarial nematode Brugia malayi is an etiological agent of Lymphatic Filariasis. The capability of B. malayi and other parasitic nematodes to modulate host biology is recognized but the mechanisms by which such manipulation occurs are obscure. An emerging paradigm is the release of parasite-derived extracellular vesicles (EV) containing bioactive proteins and small RNA species that allow secretion of parasite effector molecules and their potential trafficking to host tissues. We have previously described EV release from the infectious L3 stage B...
April 16, 2018: PLoS Neglected Tropical Diseases
Y Xue, J Wang, Y Huang, X Gao, L Kong, T Zhang, M Tang
Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal hepatic cell line (L02), and the molecular mechanisms induced by nanosilver in HepG2 cells. Nanosilver, in doses of 20-160 μg mL-1 for 24 and 48 h, reduced cell viability in a dose- and time-dependent manner and induced cell membrane leakage and mitochondria injury in both cell lines; these effects were more pronounced in HepG2 cells than in L02 cells...
January 1, 2018: Human & Experimental Toxicology
Dae Hyeok Yang, Hyun Joo Kim, Kyeongsoon Park, Jae Kwang Kim, Heung Jae Chun
Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer was compared to that of CUR solution in vitro and in vivo. Deoxycholic acid (DOCA), methoxy polyethylene glycol (MPEG) and cyanine 5.5 (cy5.5) were conjugated to the amine group of PLL through condensation reaction (PLL-DOCA-MPEG-cy5.5), followed by encapsulation of CUR by dialysis method (PLL-DOCA-MPEG-cy5.5/CUR NPs). The composition, morphology and size distribution of PLL-DOCA-MPEG-cy5...
November 2018: Drug Delivery
Meng Li, Qiong Wu, Qiangwei Wang, Dandan Xiang, Guonian Zhu
In aquatic environment, the presence of nanoparticles (NPs) has been reported to modify the bioavailability and toxicity of the organic toxicants. Nevertheless, the combined toxicity of NPs and the pesticides that were used world-widely still remains unclear. Cypermethrin (CYP), a synthetic pyrethroid insecticide, is commonly used for controlling agricultural and indoor pests. Therefore, the effects of titanium dioxide NPs (nTiO2 ) on CYP bioconcentration and its effects on the neuronal development in zebrafish were investigated in our study...
March 31, 2018: Aquatic Toxicology
Baoqiang Tang, Jennica L Zaro, Yan Shen, Qian Chen, Yinglan Yu, Pingping Sun, Yanqi Wang, Wei-Chiang Shen, Jiasheng Tu, Chunmeng Sun
Cell-penetrating peptides (CPPs) have become a novel drug delivery system due to their distinct advantages, including high cell transmembrane potency and ability to carry cargo molecules inside cells. However, owing to their cationic charge and non-specificity characteristics, the clinical application of CPPs is limited. In the current study, we engineered a reversibly activatable cell-penetrating peptide (RACPP), containing oligoarginine fused to a pH-sensitive masking sequence via a polyglycine linker ((HE)10 G5 R6 or HE-CPP) with ultra-pH-sensitivity...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Hisham A Elshoky, Taher A Salaheldin, Maha A Ali, Mohamed H Gaber
Chitosan nanoparticles have many applications, such as gene and drug delivery, due to their biocompatibility. Chitosan nanoparticles are currently produced by dissolution in acetic acid that affects the biocompatibility at acidic pH. Here, we synthesized and characterized chitosan (CS) and ascorbate chitosan (AsCS) nanoparticles and investigated their cytotoxic effects, internalization, and distribution in the human colon carcinoma cell line using confocal laser scanning microscopy (CLSM). The CS and AsCS nanoparticles were spherical with average particle sizes of 44 ± 8...
April 10, 2018: International Journal of Biological Macromolecules
Roya Biabanikhankahdani, Kok Lian Ho, Noorjahan Banu Alitheen, Wen Siang Tan
Modifications of virus-like nanoparticles (VLNPs) using chemical conjugation techniques have brought the field of virology closer to nanotechnology. The huge surface area to volume ratio of VLNPs permits multiple copies of a targeting ligand and drugs to be attached per nanoparticle. By exploring the chemistry of truncated hepatitis B core antigen (tHBcAg) VLNPs, doxorubicin (DOX) was coupled covalently to the external surface of these nanoparticles via carboxylate groups. About 1600 DOX molecules were conjugated on each tHBcAg VLNP...
April 13, 2018: Nanomaterials
Run Lin, Jing Huang, Liya Wang, Yuancheng Li, Malgorzata Lipowska, Hui Wu, Jianyong Yang, Hui Mao
Vascular endothelial growth factor (VEGF) plays a pivotal role in the cascade of development and progression of cancers. Targeting this cancer hallmark is a logical strategy for imaging based cancer detection and monitoring the anti-angiogenesis treatment. Using Bevacizumab (Avastin®), which is a recombinant humanized monoclonal antibody directly against VEGF and an angiogenesis inhibitor, as a targeting ligand, a multimodal VEGF targeted molecular imaging probe was developed by conjugating near infrared dye (NIR830) labeled bevacizumab to magnetic iron oxide nanoparticles (IONP) for optical and magnetic resonance (MR) imaging of cancers over-expressing VEGF...
April 13, 2018: Biomaterials Science
Xiaohui Wang, Hongshang Peng, Kun Cheng, Xiaoming Liu, Yuanan Liu, Wei Yang
Ratiometric fluorescent nanoparticles (NPs) under two-photon excitation are successfully developed for sensing dissolved oxygen. The NPs comprise the oxygen probe Pt(II)-porphyrins (PtTFPP) and fluorescent organic semiconducting polymer (PFO). PFO polymer acts as both a two-photon antenna and a reference dye, while PtTFPP absorbs the photonic energy transferred by the PFO under two-photon excitation at 740 nm to sense oxygen. The red fluorescence of PtTFPP is sensitive to oxygen with a quenching response of 88% from nitrogen saturation to oxygen saturation, and PFO gives oxygen-insensitive referenced blue fluorescence...
April 13, 2018: Methods and Applications in Fluorescence
M Asad Khan, Md Zafaryab, Syed M Hassan, Irfan Ahmad, Moshahid A Rizvi
Curcumin is a potent anticancer agent and has great potential efficacy against different types of cancers. A major disadvantage of curcumin, however, is its poor solubility and bioavailability. The aim of the present work is to synthesize chitosan and curcumin-loaded chitosan nanoparticles and their characterization through various physicochemical methods and cellular uptake in cervical cancer cell line SiHa. The studies presented demonstrate that curcumin-loaded chitosan nanoparticles showed increased uptake in the SiHa cells as compared to free curcumin and chitosan nanoparticles did not show any significant uptake in SiHa cell line...
April 11, 2018: Anti-cancer Agents in Medicinal Chemistry
Sotirios I Sinis, Chrissi Hatzoglou, Konstantinos I Gourgoulianis, Sotirios G Zarogiannis
Nanoparticles have great potential for numerous applications due to their unique physicochemical properties. However, concerns have been raised that they may induce deleterious effects on biological systems. There is accumulating evidence that, like asbestos, inhaled nanomaterials of >5 μm and high aspect ratio (3:1), particularly rod-like carbon nanotubes, may inflict pleural disease including mesothelioma. Additionally, a recent set of case reports suggests that inhalation of polyacrylate/nanosilica could in part be associated with inflammation and fibrosis of the pleura of factory workers...
2018: Frontiers in Physiology
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