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nanoparticles uptake

Enza Fazio, Antonio Speciale, Salvatore Spadaro, Martina Bonsignore, Francesco Cimino, Mariateresa Cristani, Domenico Trombetta, Antonella Saija, Fortunato Neri
Tailored colloids of uniformly sized and engineered molybdenum oxide nanoparticles were produced, for the first time, by pulsed laser ablation in water. This green technique ensures the formation of contaminant-free nanostructures and the absence of by-products, very useful issues in biological applications. A selective tuning of MoO chemical bonding configurations and a suitable control of nanoparticles size distributions were achieved during the ablation processes by varying the water temperature and by applying an external electric field...
June 18, 2018: Colloids and Surfaces. B, Biointerfaces
Asima Farooq, Ali Shukur, Cai Astley, Lubomira Tosheva, Peter Kelly, Debra Whitehead, May Azzawi
Blood vessel disease is a major contributor to cardiovascular morbidity and mortality and is hallmarked by dysfunction of the lining endothelial cells (ECs). These cells play a significant role in vascular homeostasis, through the release of mediators to control vessel diameter, hence tissue perfusion. Mesoporous silica nanoparticles (MSNs) can be used as potential drug delivery platforms for vasodilator drugs. Here, using an ex vivo model of vascular function, we examine the use of titania coating for improved biocompatibility and release dynamics of MSN loaded sodium nitroprusside (SNP)...
June 19, 2018: Acta Biomaterialia
Bobbi S Stromer, Sonali Roy, Melissa R Limbacher, Bardwi Narzary, Manobjyoti Bordoloi, Julia Waldman, Challa V Kumar
Synthesis, characterization, and applications of strongly fluorescent, multicolored protein nanoparticles (GlowDots) are re-ported here. Bovine serum albumin was cross-linked under controlled conditions to form nanoparticles, where particle size was controlled from 20 to 100 ± 10 nm by choosing appropriate reaction conditions. The absorption as well as the emission wavelengths were controlled without changing the particle size, unlike quantum dots. Each GlowDot was loaded with up to 214  50 chromophores and hence, the particles have high molar absorptivities (106 M-1cm-1) as well as high brightness (105 to 106 M-1cm-1)...
June 22, 2018: Bioconjugate Chemistry
Qunqun Bao, Ping Hu, Yingying Xu, Tiansheng Cheng, Chenyang Wei, Limin Pan, Jianlin Shi
Cerebral vasculature and neuronal networks will be largely destroyed due to the oxidative damages by over-produced reactive oxygen species (ROS) during stroke, accompanied by the symptoms of ischemic injury and blood-brain barrier (BBB) disruption. Ceria nanoparticles, acting as an effective and recyclable ROS scavenger, have been showing high effectiveness in neuroprotection. However, the brain access of nanoparticles can only be achieved by targeting the damaged area of BBB, leading to the disrupted BBB unprotected and turbulence of microenvironment in brain...
June 22, 2018: ACS Nano
Kasper Bendix Johnsen, Martin Bak, Paul Joseph Kempen, Fredrik Melander, Annette Burkhart, Maj Schneider Thomsen, Morten Schallburg Nielsen, Torben Moos, Thomas Lars Andresen
Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy to give a preferential accumulation of drugs or nanomedicines, but several aspects of this targeting strategy remain elusive. Here we report that TfR-targeted gold nanoparticles (AuNPs) can accumulate in brain capillaries and further transport across the BBB to enter the brain parenchyma...
2018: Theranostics
Shengchang Zhang, Lin Wu, Jin Cao, Kaili Wang, Yanru Ge, Wanjun Ma, Xueyong Qi, Song Shen
Nanoparticles based multifunctional system exhibits great potential in diagnosis and therapy of rheumatoid arthritis (RA). The size of nanoparticles plays an essential role in biodistribution and cellular uptake, in turn affects the drug delivery efficiency and therapeutic effect. To investigate the optimal size for RA targeting, Fe3 O4 nanoparticles with well-defined particle sizes (70-350 nm) and identical surface properties were developed as model nanoparticles. The synthesized Fe3 O4 nanoparticles exhibited excellent biocompatibility and showed higher temperature response under irradiation of near infrared light...
June 13, 2018: Colloids and Surfaces. B, Biointerfaces
Jinlong Zhao, Xueyan Zhang, Xiangshi Sun, Menghui Zhao, Changhui Yu, Robert J Lee, Fengying Sun, Yulin Zhou, Youxin Li, Lesheng Teng
Methotrexate (MTX), as a disease modifying antirheumatic drug (DMARD), was first line drug to treat rheumatoid arthritis. However, the severe side effect during long term and high dosage usage limit its application. The aim of this study was to develop dual-functional lipid polymeric hybrid pH-responsive nanoparticles to deliver MTX to inflamed joints selectively. The designed MTX loaded stearic acid-octa-arginine and folic acid decorated poly lactic-co-glycolic acid (PLGA) -PK3-based lipid polymeric hybrid nanoparticles (Sta-R8-FA-PPLPNs/MTX) were composed of PK3, Folate-PEG-PLGA, egg PC, and Sta-R8...
June 18, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Julian Burks, Sandeep Nadella, Abdullah Mahmud, Charoen Mankongpaisarnrung, Juan Wang, Jong-In Hahm, Robin D Tucker, Narayan Shivapurkar, Stephan T Stern, Jill P Smith
Background & Aims: Pancreatic ductal adenocarcinoma (PDAC) remains the most aggressive malignancy with the lowest 5-year survival rate of all cancers in part owing to the lack of tumor-specific therapy and the rapid metastatic nature of this cancer. The gastrointestinal peptide gastrin is a trophic peptide that stimulates growth of PDAC in an autocrine fashion by interaction with the cholecystokinin receptor that is overexpressed in this malignancy. Methods: We developed a therapeutic novel polyplex nanoparticle (NP) that selectively targets the cholecystokinin receptor on PDAC...
2018: Cellular and Molecular Gastroenterology and Hepatology
Alessandro Bertucci, Simone Silvestrini, Roberto Corradini, Luisa De Cola
Peptide Nucleic Acids (PNAs) are oligonucleotide mimics that can be used as drugs as they can interact with DNA and RNA targets in organisms. Loading PNAs into inorganic nanocarriers can improve their cellular uptake and co-delivering them together with drugs can improve the therapy efficacy by synergic effects. Furthermore, the functionalization of the carriers with labels allows theranostics, and the possibility to monitor the efficacy of the therapy in real time. The present protocol describes the synthesis of Zeolites-L nanocrystals and mesoporous silica nanoparticles and their loading with cationic PNAs and other smaller molecular weight payloads towards theranostics applications...
2018: Methods in Molecular Biology
Yan Teck Ho, Roger D Kamm, James Chen Yong Kah
Transcytosis of nanoparticles (NPs) is emerging as an attractive alternative to the paracellular route in cancer drug delivery with studies suggesting targeting caveolae-mediated endocytosis to maximize NP transcytosis. However, there are limited studies on transcytosis of NPs, especially for corona-coated NPs. Most studies focused on cellular uptake as an indirect measure of the NP's transcellular permeability (Pd). Here, we probed the effect of protein corona on the uptake and transcytosis of 20, 40, 100, and 200 nm polystyrene nanoparticles (pNP-PC) across HUVECs in a microfluidic channel that modelled the microvasculature...
June 21, 2018: Nanoscale
Dana Westmeier, Djamschid Solouk-Saran, Cecilia Vallet, Svenja Siemer, Dominic Docter, Hermann Götz, Linda Männ, Anja Hasenberg, Angelina Hahlbrock, Kathrin Erler, Christoph Reinhardt, Oliver Schilling, Sven Becker, Matthias Gunzer, Mike Hasenberg, Shirley K Knauer, Roland H Stauber
Airborne fungal pathogens, predominantly Aspergillus fumigatus , can cause severe respiratory tract diseases. Here we show that in environments, fungal spores can already be decorated with nanoparticles. Using representative controlled nanoparticle models, we demonstrate that various nanoparticles, but not microparticles, rapidly and stably associate with spores, without specific functionalization. Nanoparticle-spore complex formation was enhanced by small nanoparticle size rather than by material, charge, or "stealth" modifications and was concentration-dependently reduced by the formation of environmental or physiological biomolecule coronas...
June 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Mohammad R Khan, Jayesh Dudhia, Frederic H David, Roberta De Godoy, Vedika Mehra, Gillian Hughes, Stephanie G Dakin, Andrew J Carr, Allen E Goodship, Roger K W Smith
BACKGROUND: Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem cells (MSCs) although the effects of the intra-synovial environment on the distribution, engraftment and functionality of implanted MSCs is not known. This study utilised a novel sheep model which, although in an anatomically different location, more accurately mimics the mechanical and synovial environment of the human rotator cuff, to determine the effects of intra-synovial implantation of MSCs...
June 19, 2018: Stem Cell Research & Therapy
Udonna Ndu, Geoff A Christensen, Nelson A Rivera, Caitlin M Gionfriddo, Marc A Deshusses, Dwayne A Elias, Heileen Hsu-Kim
Mercury (Hg)-contaminated sediment and water contain various Hg species, with a small fraction available for microbial conversion to the bioaccumulative neurotoxin monomethylmercury (MeHg). Quantification of this available Hg pool is needed to prioritize sites for risk management. This study compared the efficacy of diffusive gradient in thin-film (DGT) passive samplers to a thiol-based selective extraction method with glutathione (GSH) and conventional filtration (<0.2 μm) as indicators of Hg bioavailability...
June 19, 2018: Environmental Science & Technology
Wenhong Fan, Huiting Lu, Wen-Xiong Wang
Nanoparticles functionalized with various surface capping moieties are now widely used in various fields, thus there is a major need to understand the behavior and fate of these nanoparticles in the environments. The present study investigated the biokinetics of two commercial functional TiO2 NPs with different surface chemistries which had changed significantly with aging. The accumulated Ti in a freshwater cladoceran Daphnia magna increased with time under two exposure concentrations. Efflux experiments showed that the efflux pattern of all treatments followed a two-compartmental depuration...
June 19, 2018: Environmental Science & Technology
Yawei Li, Na Xu, Wenhe Zhu, Lei Wang, Bin Liu, Jianxu Zhang, Zhigang Xie, Wensen Liu
The cytolytic peptide melittin (MLT) is an important candidate of anticancer drug owing to its hemolytic properties. Nevertheless, its clinical applications are severely restricted as a result of its non-specific toxicities like hemolysis. In this work, we reported MLT-loaded zeolitic imidazolate framework-8 (MLT@ZIF-8) nanoparticles (NPs). The formed MLT@ZIF-8 NPs not only possess excellent stability but also efficiently inhibit the hemolysis bioactivity of MLT. Confocal scanning imaging and cytotoxicity experiments revealed that as-synthesized MLT@ZIF-8 NPs exhibit enhanced cellular uptake and cytotoxicity toward cancer cells compared to MLT...
June 19, 2018: ACS Applied Materials & Interfaces
Xiaolong Tang, Longzhou Chen, Amin Li, Shiyu Cai, Yinci Zhang, Xueke Liu, Zhenyou Jiang, Xinkuang Liu, Yong Liang, Dong Ma
Sorafenib (SFB) has improved the treatment of hepatocellular carcinoma (HCC) and has fewer severe side effects than other agents used for that purpose. However, due to a lack of tumor-specific targeting, the concentration of the drug in tumor tissue cannot be permanently maintained at a level that inhibits tumor growth. To overcome this problem, we developed a novel SFB-loaded polymer nanoparticle (NP). The NP (a TPGS-b-PCL copolymer that was synthesized from ε-caprolactone and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via ring-opening polymerization) contains Pluronic P123 and SFB, and its surface is modified with anti-GPC3 antibody to produce the polymer nanoparticle (NP-SFB-Ab)...
November 2018: Drug Delivery
Mohammad Mahmoudian, Sara Salatin, Ahmad Yari Khosroushahi
Lipoproteins (LPs) are a set of naturally occurring bio-nanoparticles consisting of Apo-LPs, phospholipids, a highly hydrophobic core of cholesteryl esters and triglycerides that participate mainly in the targeted transport of cholesteryl esters and other hydrophobic molecules through the bloodstream. They also are able to recognize specific receptors on normal and abnormal cells. Therefore, LPs represent a relevant tool for targeted delivery of cancer diagnostics and therapeutics due to their native biocompatibility, biodegradability, nano-scale size and receptor-mediated uptake...
June 18, 2018: Cancer Chemotherapy and Pharmacology
Rolf F Barth, Peng Mi, Weilian Yang
Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron-10, is irradiated with neutrons to produce high energy alpha particles. This review will focus on tumor-targeting boron delivery agents that are an essential component of this binary system. Two low molecular weight boron-containing drugs currently are being used clinically, boronophenylalanine (BPA) and sodium borocaptate (BSH). Although they are far from being ideal, their therapeutic efficacy has been demonstrated in patients with high grade gliomas, recurrent tumors of the head and neck region, and a much smaller number with cutaneous and extra-cutaneous melanomas...
June 19, 2018: Cancer communications
Hao Dong, Guoyu Wu, Hong Xu, Chenghong Zhang, Jiao Wang, Meng Gao, Yue Pang, Houli Zhang, Baojing Zhang, Yan Tian, Qingwei Li
Primary liver cancer (PLC) is one of the most common malignant tumours and has the third highest mortality rate worldwide. An active liver-targeting drug delivery system via the asialoglycoprotein receptors expressed in the hepatic parenchyma cells of mammals has become a research focus for the treatment of PLC. N-acetylaminogalactosyl-poly(lactide-co-glycolide)-succinyl-D-α-tocopherol polyethylene glycol 1000 succinate (GalNAc-PLGA-sTPGS) was synthesized to achieve active liver-targeting properties. Emodin (EMO)-loaded GalNAc-PLGA-sTPGS nanoparticles (EGPTN) were prepared with EMO which was selected for its potential antitumour efficacy...
June 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Dhamia K Suker, Fatimah A Jasim
Aim: The present study designed to evaluate the toxic effect of anatase TiO2 NPs on BALF biochemical changes and liver alteration in rats. Background: Titanium dioxide (TiO2) nanoparticles (NPs) are utilized in food color additives and cosmetics worldwide. Humans uptake these nanoparticulate by different routes and may exhibit potential side effects, lags behind the rapid development of nanotechnology. Methods: Sixty-three mats rats were used...
2018: Gastroenterology and Hepatology From Bed to Bench
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