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insulin-like growth factor

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https://www.readbyqxmd.com/read/29456350/recurrent-glioblastomas-exhibit-higher-expression-of-biomarkers-with-stem-like-properties
#1
B N Nandeesh, Sharmistha Naskar, Arun H Shashtri, A Arivazhagan, Vani Santosh
Background: Despite advances in the treatment of glioblastoma (GBM), the prognosis of patients continues to remain dismal. This unfavorable prognosis is mainly attributed to the tumor's propensity for progression and recurrence, which in turn is due to the highly aggressive nature of the persisting GBM cells that actively egress from the main tumor mass into the surrounding normal brain tissue. Such a recurrent tumor described to have a more malignant potential is highly invasive and resistant to current therapies, probably due to increased stemness and preferential selection of therapy-resistant clones of tumor cells...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455671/oncogenic-fusion-proteins-adopt-the-insulin-like-growth-factor-signaling-pathway
#2
REVIEW
Haim Werner, Shilhav Meisel-Sharon, Ilan Bruchim
The insulin-like growth factor-1 receptor (IGF1R) has been identified as a potent anti-apoptotic, pro-survival tyrosine kinase-containing receptor. Overexpression of the IGF1R gene constitutes a typical feature of most human cancers. Consistent with these biological roles, cells expressing high levels of IGF1R are expected not to die, a quintessential feature of cancer cells. Tumor specific chromosomal translocations that disrupt the architecture of transcription factors are a common theme in carcinogenesis...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29455661/development-of-a-4-aminopyrazolo-3-4-d-pyrimidine-based-dual-igf1r-src-inhibitor-as-a-novel-anticancer-agent-with-minimal-toxicity
#3
Ho Jin Lee, Phuong Chi Pham, Seung Yeob Hyun, Byungyeob Baek, Byungjin Kim, Yunha Kim, Hye-Young Min, Jeeyeon Lee, Ho-Young Lee
BACKGROUND: Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous types of human cancer, and Src activation confers resistance to anti-IGF1R therapies. Hence, targeting both IGF1R and Src concurrently is one of the main challenges in combating resistance to the currently available anti-IGF1R-based anticancer therapies. However, the enhanced toxicity from this combinatorial treatment could be one of the main hurdles for this strategy, suggesting the necessity of developing a novel strategy for co-targeting IGF1R and Src to meet an urgent clinical need...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29455576/central-infusion-of-igf-1-increases-hippocampal-neurogenesis-and-improves-neurobehavioral-function-following-traumatic-brain-injury
#4
Shaun W Carlson, Kathryn E Saatman
Traumatic brain injury (TBI) produces neuronal dysfunction and cellular loss that can culminate in lasting impairments in cognitive and motor abilities. Therapeutic agents that promote repair and replenish neurons after TBI hold promise in improving recovery of function. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice; however, the translational neurogenic potential of exogenously administered IGF-1 after TBI remains unknown...
February 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29455465/insulin-like-growth-factor-2-a-poor-prognostic-biomarker-linked-to-racial-disparity-in-women-with-uterine-carcinosarcoma
#5
Anne R Van Arsdale, Rebecca C Arend, Maria J Cossio, Britt K Erickson, Yanhua Wang, David W Doo, Charles A Leath, Gary L Goldberg, Gloria S Huang
The objective of this study was to investigate the relationship of insulin-like growth factor 2 (IGF2) expression and survival in women with uterine carcinosarcoma (UCS). Insulin-like growth factor 2 protein expression was determined by immunohistochemical staining of tumor tissues from 103 patients with UCS. The H-score (product of staining intensity and percentage positive cells) was quantified for the epithelial cytoplasmic (EC), epithelial nuclear (EN), and malignant stromal compartments. Multivariable Cox proportional hazard regression models were used to examine the relationship of IGF2 levels with progression-free survival (PFS) and overall survival (OS)...
February 18, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29455208/rhigf-1-treatment-increases-bone-mineral-density-and-trabecular-bone-structure-in-children-with-papp-a2-deficiency
#6
Federico G Hawkins-Carranza, María T Muñoz-Calvo, Gabriel Á Martos-Moreno, Gonzalo Allo-Miguel, Luis Del Río, Jesús Pozo, Julie A Chowen, Luis A Pérez-Jurado, Jesús Argente
AIM: Our objective was to determine changes in bone mineral density (BMD), trabecular bone score (TBS), and body composition after 2 years of therapy with recombinant human insulin-like growth factor-1 (rhIGF-1) in 2 prepubertal children with a complete lack of circulating PAPP-A2 due to a homozygous mutation in PAPP-A2 (p.D643fs25*) resulting in a premature stop codon. METHODS: Body composition, BMD, and bone structure were determined by dual-energy X-ray absorptiometry at baseline and after 1 and 2 years of rhIGF-1 treatment...
February 16, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29454514/phase-2-study-evaluating-intermittent-and-continuous-linsitinib-and-weekly-paclitaxel-in-patients-with-recurrent-platinum-resistant-ovarian-epithelial-cancer
#7
Amit Oza, Stanley Kaye, Jan Van Tornout, Cristiana Sessa, Martin Gore, R Wendel Naumann, Hal Hirte, Nicoletta Colombo, Jihong Chen, Seema Gorla, Srinivasu Poondru, Margaret Singh, Joyce Steinberg, Geoff Yuen, Susana Banerjee
BACKGROUND: Linsitinib, an oral, dual inhibitor of insulin-like growth factor-1 receptor and insulin receptor, in combination with weekly paclitaxel, may improve clinical outcomes compared with paclitaxel alone in patients with refractory or platinum-resistant ovarian cancer. PATIENTS AND METHODS: This open-label phase 1/2 clinical trial (NCT00889382) randomized patients with refractory or platinum-resistant ovarian cancer (1:1:1) to receive either oral intermittent linsitinib (600mg once daily on Days 1-3 per week) combined with paclitaxel (80mg/m2 on Days 1, 8, and 15; Arm A) or continuous linsitinib (150mg twice daily) in combination with paclitaxel (Arm B), or paclitaxel alone (Arm C)...
February 14, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29453428/igf-i-and-igfbp-3-concentrations-at-2-years-associations-with-anthropometry-and-milk-consumption-in-an-indian-cohort
#8
Andrea S Wiley, Suyog M Joshi, Himangi G Lubree, Dattatray S Bhat, Neelam S Memane, Deepa A Raut, Chittaranjan S Yajnik
BACKGROUND/OBJECTIVES: To ascertain associations between plasma insulin-like growth factor I (IGF-I), insulin-like growth factor-binding protein 3 (IGFBP-3) and their molar ratio at 2 y with neonatal size, infant growth, body composition at 2 y, and feeding practices in an Indian cohort. SUBJECTS/METHODS: A cohort of 209 newborns, with 122 followed at 2 y. Anthropometry was conducted at birth and 2 y. IGF-I and IGFBP-3 concentrations were measured in cord blood and at 2 y...
February 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29453285/the-distal-upstream-region-of-insulin-like-growth-factor-binding-protein-1-enhances-its-expression-in-endometrial-stromal-cells-during-decidualization
#9
Isao Tamura, Kosuke Jozaki, Shun Sato, Yuichiro Shirafuta, Masahiro Shinagawa, Ryo Maekawa, Toshiaki Taketani, Hiromi Asada, Hiroshi Tamura, Norihiro Sugino
We have previously shown that decidualization of human endometrial stromal cells (ESCs) causes a genome-wide increase in the levels of acetylation of histone-H3 Lys-27 (H3K27ac). We also reported that the distal gene regions, more than 3 kb up or downstream of gene transcription start sites have increased H3K27ac levels. Insulin-like growth factor-binding protein-1 (IGFBP-1) is a specific decidualization marker and has increased H3K27ac levels in its distal upstream region (-4701 bp to -7501 bp). Here, using a luciferase reporter gene construct containing this IGFBP-1 upstream region, we tested the hypothesis that it is an IGFBP-1 enhancer...
February 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29452886/shifting-the-igf-axis-an-age-related-decline-in-human-tear-igf-1-correlates-with-clinical-signs-of-dry-eye
#10
Roshni Patel, Meifang Zhu, Danielle M Robertson
OBJECTIVE: The human corneal epithelium expresses both the insulin-like growth factor type 1 receptor (IGF-1R) and the IGF-1R/insulin receptor (INSR) hybrid. Despite the previous identification of IGF-1 in human tear fluid, little is known regarding the regulation of IGF-1 in tear fluid and its role in corneal epithelial homeostasis. In the present study, we investigated the impact of biological parameters on the concentration of human tear levels of IGF-1. DESIGN: Tear levels of IGF-1 were measured in 41 healthy, human volunteers without any reported symptoms of dry eye...
February 6, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29452017/fractional-non-ablative-laser-assisted-drug-delivery-leads-to-improvement-in-male-and-female-pattern-hair-loss
#11
Ana Carina Junqueira Bertin, Adriana Vilarinho, Ana Lúcia Ariano Junqueira
Androgenetic alopecia, also known as male and female pattern hair loss, is a very prevalent condition; however, approved therapeutic options are limited. Fractionated laser has been proposed to assist in penetration of topical medications to the cutaneous tissue. We present four cases of androgenetic alopecia that underwent treatment with a non-ablative erbium glass fractional laser followed by the application of topical finasteride 0,05% and growth factors including basic fibroblast growth factor, insulin-like growth factor, vascular endothelial growth factor, and copper peptide 1%...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29451701/phase-1b-study-of-pasireotide-everolimus-and-selective-internal-radioembolization-therapy-for-unresectable-neuroendocrine-tumors-with-hepatic-metastases
#12
Hyun S Kim, Walid L Shaib, Chao Zhang, Ganji Purnachandra Nagaraju, Christina Wu, Olatunji B Alese, Zhengjia Chen, Edith Brutcher, Meredith Renfroe, Bassel F El-Rayes
BACKGROUND: Neuroendocrine tumors (NETs) metastasize to the liver. Everolimus and selective internal radioembolization (SIRT) are approved treatments. Pasireotide is a somatostatin analogue with an affinity for somatostatin receptors 1, 2, 3, and 5. Everolimus and pasireotide may potentiate SIRT radiosensitization and inhibit rebound angiogenesis. This study evaluated the safety of pasireotide, everolimus, and SIRT. METHODS: This 3 + 3 phase 1 trial evaluated 3 dose levels of everolimus (2...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29451227/statural-growth-and-prevalence-of-endocrinopathies-in-relation-to-liver-iron-content-lic-in-adult-patients-with-beta-thalassemia-major-btm-and-sickle-cell-disease-scd
#13
Mohamed A Yassin, Ashraf T Soliman, Vincenzo De Sanctis, Mohammad Aj Abdula, Lubna M Riaz, Firdous F Ghori, Anil Yousaf, Abdulqadir J Nashwan, Sandara Abusamaan, Abbas Moustafa, Samah Kohla, Dina S Soliman
Despite regular blood transfusion and iron chelation therapy, growth impairment and pubertal delay are commonly seen in children and adolescents with transfusion-dependent Beta thalassaemia major (BTM) and sickle cell disease (SCD). We evaluated growth parameters and endocrine disorders in relation to the liver iron concentration (LIC) assessed by the Ferriscan® method in a cohort of adults with SCD (n =40) and BTM (n = 52) receiving blood transfusions and iron chelation therapy since early childhood. Before transfusion, hemoglobin concentration had not been less than 9 g/dl in the past 12 years; subcutaneous daily desferrioxamine was administered for all of them since early childhood (2- 5 years of age)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29450728/winter-vitamin-d-3-supplementation-does-not-increase-muscle-strength-but-modulates-the-igf-axis-in-young-children
#14
Charlotte Mortensen, Christian Mølgaard, Hanne Hauger, Michael Kristensen, Camilla T Damsgaard
PURPOSE: To explore whether muscle strength, the insulin-like growth factor axis (IGF-axis), height, and body composition were associated with serum 25-hydroxyvitamin D [25(OH)D] and affected by winter vitamin D supplementation in healthy children, and furthermore to explore potential sex differences. METHODS: We performed a double-blind, placebo-controlled, dose-response winter trial at 55ºN. A total of 117 children aged 4-8 years were randomly assigned to either placebo, 10, or 20 µg/day of vitamin D 3 for 20 weeks...
February 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29448973/camp-response-element-binding-protein-1-controls-porcine-ovarian-cell-proliferation-apoptosis-and-fsh-and-insulin-like-growth-factor-1-response
#15
A V Sirotkin, A Benčo, A Tandlmajerová, M Lauková, D Vašíček, J Laurinčik, J Kornhauser, S Alwasel, A H Harrath
The aim of the present study was to examine the role of cAMP response element-binding protein (CREB) and its phosphorylation in the regulation of ovarian cell proliferation and apoptosis, and of the response of proliferation and apoptosis to the upstream hormonal stimulators FSH and insulin-like growth factor (IGF) 1. In the first series of experiments, porcine ovarian granulosa cells, transfected or not with a gene construct encoding wild-type CREB1 (CREB1WT), were cultured with and without FSH (0, 1, 10 or 100ngmL-1)...
February 16, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29447858/intrathecal-injection-of-scaav9-higf1-prolongs-the-survival-of-als-model-mice-by-inhibiting-the-nf-kb-pathway
#16
HaoJie Hu, HuiQian Lin, WeiSong Duan, Can Cui, ZhongYao Li, YaKun Liu, Wan Wang, Di Wen, Ying Wang, ChunYan Li
Amyotrophic lateral sclerosis (ALS) is a chronic, fatal neurodegenerative disorder characterized by the progressive loss of upper and lower motor neurons. Currently, there is no effective drug for ALS. Recent studies in ALS model mice have shown that insulin-like growth factor-1 (IGF1) may be a promising therapeutic drug. We demonstrate that self-complementary adeno-associated virus serum type 9 encoding the human IGF1 (scAAV9-hIGF1) could significantly postpone the onset and slow down the progression of the disease owning to inhibiting the NF-κB signalling pathway...
February 12, 2018: Neuroscience
https://www.readbyqxmd.com/read/29447340/dysfunction-of-ddit4-in-the-decidua-is-relevant-to-the-pathogenesis-of-preeclampsia
#17
Jieqiong Yang, Yachao Zhang, Jing Tong, Hong Lv, Cong Zhang, Zi-Jiang Chen
Preeclampsia (PE) is a pregnancy-related disorder that occurs after 20 weeks of gestation and affects 3-5% of all human pregnancies worldwide. However, the pathogenesis of PE still remains poorly understood. A deficiency in decidualization is considered a contributing factor to the development of PE. The DNA damage inducible transcript 4 (DDIT4) gene encodes a protein whose main function is inhibiting mammalian target of rapamycin (mTOR) under stress, and several studies have demonstrated that its expression promotes tumor cell apoptosis...
February 13, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29447074/social-cognition-in-the-course-of-psychosis-and-its-correlation-with-biomarkers-in-a-male-cohort
#18
Evangelos Ntouros, Evangelos Karanikas, Georgios Floros, Christina Andreou, Aikaterini Tsoura, Georgios Garyfallos, Vasilios P Bozikas
INTRODUCTION: Patients diagnosed with schizophrenia display deficits in Theory of Mind (ToM) and Emotion Perception (EP) even before the appearance of full-blown symptomatology. METHODS: We evaluated ToM and EP in a male cohort consisting of 25 First Episode Psychosis (FEP) and 16 relapsed schizophrenic patients (CHRON) compared to 12 subjects in Ultra-high Risk (UHR) and 23 healthy controls (CTR). Furthermore, we measured the levels of Cortisol, Insulin like Growth Factor (IGF-1), TNF-a, TNF-b and several interleukins as potential biomarkers...
February 15, 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29444261/selective-androgen-receptor-modulator-s42-suppresses-prostate-cancer-cell-proliferation
#19
Takako Kawanami, Tomoko Tanaka, Yuriko Hamaguchi, Takashi Nomiyama, Hajime Nawata, Tosihiko Yanase
We previously identified a novel selective androgen receptor modulator (SARM), S42, which does not stimulate prostate growth but has a beneficial effect on lipid metabolism. In the prostate cancer (PC) cell line LNCaP, S42 did not induce androgen receptor (AR) transactivation but antagonized 5α-dihydrotestosterone (DHT)-induced AR activation. Next, we investigated whether S42 suppresses the growth of PC cell lines. Basal growth of LNCaP cells was significantly suppressed by treatment with S42 compared with vehicle, as determined by cell counting and BrdU assays...
February 12, 2018: Endocrinology
https://www.readbyqxmd.com/read/29443548/sex-and-bone-specific-responses-in-bone-structure-to-exogenous-leptin-and-leptin-receptor-antagonism-in-the-ovine-fetus
#20
Miles J De Blasio, Stuart A Lanham, Dominique Blache, Richard Oc Oreffo, Abigail L Fowden, Alison J Forhead
Widespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using micro-computed tomography, this study investigated the effects of exogenous leptin and leptin receptor antagonism on aspects of bone structure in the sheep fetus during late gestation. From 125-130 days of gestation (term ~145 days), chronically-catheterised singleton sheep fetuses were infused intravenously for five days with either saline (0.9% saline, n=13), recombinant ovine leptin at two doses (0...
February 14, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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