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https://www.readbyqxmd.com/read/29765284/influence-of-serum-leptin-levels-and-q223r-leptin-receptor-polymorphism-on-clinical-characteristic-of-patients-with-rheumatoid-arthritis-from-western-mexico
#1
Luis I Angel-Chávez, Elizabeth Ruelas-Cinco, Jorge Hernández-Bello, Elena Castro, Mirna Vázquez-Villamar, Isela Parra-Rojas, L Michele Brennan-Bourdon, Salvador Muñoz-Barrios, Celia Guerrero-Velázquez, José Francisco Muñoz-Valle
Objective: The aim of the present study was to evaluate the possible association between the Q223R Leptin receptor (LEPR) polymorphism (A>G; rs1137101) and leptin levels in patients with rheumatoid arthritis (RA) from Western Mexico. Methods: A cross-sectional study was performed with 70 RA patients and 74 controls subject (CS). Disease activity was evaluated using DAS28 score, the Q223R LEPR polymorphism was determined by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and serum leptin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF) were quantified...
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29761783/preoptic-leptin-signaling-modulates-energy-balance-independent-of-body-temperature-regulation
#2
Sangho Yu, Helia Cheng, Marie François, Emily Qualls-Creekmore, Clara Huesing, Yanlin He, Yanyan Jiang, Hong Gao, Yong Xu, Andrea Zsombok, Andrei V Derbenev, Eduardo A Nillni, David H Burk, Christopher D Morrison, Hans-Rudolf Berthoud, Heike Münzberg
The adipokine leptin acts on the brain to regulate energy balance but specific functions in many brain areas remain poorly understood. Among these, the preoptic area (POA) is well known to regulate core body temperature by controlling brown fat thermogenesis, and we have previously shown that glutamatergic, long-form leptin receptor (Lepr)-expressing neurons in the POA are stimulated by warm ambient temperature and suppress energy expenditure and food intake. Here we further investigate the role of POA leptin signaling in body weight regulation and its relationship to body temperature regulation in mice...
May 15, 2018: ELife
https://www.readbyqxmd.com/read/29761750/obesity-disrupts-rhythmic-clock-gene-expression-in-maternal-adipose-tissue-during-rat-pregnancy
#3
Rachael C Crew, Peter J Mark, Brendan J Waddell
Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock also undergoes major change as part of the maternal metabolic adaptation to pregnancy, but whether this is affected by maternal obesity is unknown. Consequently, in this study we tested the hypothesis that obesity disturbs rhythmic gene expression in maternal adipose tissue across pregnancy...
June 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29749830/lepr-gene-polymorphism-and-plasma-soluble-leptin-receptor-levels-are-associated-with-polycystic-ovary-syndrome-in-han-chinese-women
#4
Xiaoyu Tu, Chuanning Yu, Minzhi Gao, Yu Zhang, Zhaofeng Zhang, Yaqiong He, Lihua Yao, Jing Du, Yun Sun, Zhaogui Sun
AIM: To investigate the association of LEPR polymorphisms and plasma leptin and soluble leptin receptor (sOB-R) levels with polycystic ovary syndrome (PCOS) in Chinese women. PATIENTS & METHODS: LEPR Lys109Arg (rs1137100) and Gln223Arg (rs1137101) polymorphisms of PCOS patients and the controls were genotyped. Plasma leptin and sOB-R levels of two groups were measured. RESULTS: The genotypic distributions of Lys109Arg (rs1137100) differed between the PCOS and control groups...
July 2017: Personalized Medicine
https://www.readbyqxmd.com/read/29747813/biology-of-gm3-ganglioside
#5
Jin-Ichi Inokuchi, Kei-Ichiro Inamori, Kazuya Kabayama, Masakazu Nagafuku, Satoshi Uemura, Shinji Go, Akemi Suzuki, Isao Ohno, Hirotaka Kanoh, Fumi Shishido
Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3. We have identified isoforms of GM3S proteins having distinctive lengths of N-terminal cytoplasmic tails, and found that these cytoplasmic tails define subcellular localization, stability, and in vivo activity of GM3S isoforms...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29744713/fabp2-lepr223-lep656-and-fto-polymorphisms-effect-on-weight-loss-2-years-after-bariatric-surgery
#6
Natália Luiza Kops, Manoela A Vivan, Jaqueline D C Horvath, Mariana L D de Castro, Rogério Friedman
PURPOSE: Differences in weight loss outcomes after bariatric surgery may be related to individual preoperative characteristics. The aim of this study was to evaluate the potential effect of fatty acid binding protein-2 (rs1799883), leptin receptor (LEP223, rs1137101 and LEP656, rs1805094), and fat mass and obesity-related (rs9939609) genotypes on weight loss 2 years after bariatric surgery in Brazilian patients. MATERIALS AND METHODS: Prospective observational study involving 105 patients (lost to follow-up, 25...
May 9, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29742429/diet-induced-growth-is-regulated-via-acquired-leptin-resistance-and-engages-a-pomc-somatostatin-growth-hormone-circuit
#7
Heiko Löhr, Simon Hess, Mafalda M A Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M Wunderlich, Peter Kloppenburg, Jens C Brüning, Matthias Hammerschmidt
Anorexigenic pro-opiomelanocortin (Pomc)/alpha-melanocyte stimulating hormone (αMSH) neurons of the hypothalamic melanocortin system function as key regulators of energy homeostasis, also controlling somatic growth across different species. However, the mechanisms of melanocortin-dependent growth control still remain ill-defined. Here, we reveal a thus-far-unrecognized structural and functional connection between Pomc neurons and the somatotropic hypothalamo-pituitary axis. Excessive feeding of larval zebrafish causes leptin resistance and reduced levels of the hypothalamic satiety mediator pomca...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29741413/association-between-immigration-history-and-inflammatory-marker-profiles-among-older-adult-mexican-americans
#8
Chantel L Martin, Mary N Haan, Lindsay Fernandez-Rhodes, Anne Lee, Allison E Aiello
Foreign-born Hispanics have better cardiometabolic health upon arrival in the US than their US-born counterparts, yet this advantage diminishes as duration of residence in the US increases. Underlying mechanisms explaining this paradox have been understudied. Using data from the Sacramento Area Latino Study on Aging (SALSA), this study examined immigration history (immigrant generation and duration of US residence) in relation to biomarkers of inflammation (interleukin-6 (IL-6), soluble forms of type 1 and 2 receptors of tumor necrosis factor-alpha (sTNF-R1 and sTNF-R2), C-reactive protein (CRP), leptin, adiponectin) in a sample of 1,290 predominantly Mexican-origin immigrants...
January 2018: Biodemography and Social Biology
https://www.readbyqxmd.com/read/29740882/differential-gene-expression-of-eph-ephrin-a1-and-lepr-lep-with-high-or-low-number-of-embryos-in-pigs-during-implantation
#9
Y Fu, R V Knox, L Li, S Ren
The objective of this study was to ascertain whether mRNA and protein expressions of implantation-related genes (erythropoietin-producing hepatocellular receptor-ligand A1, Eph-ephrin A1 and leptin receptor-leptin, LEPR-LEP) differed between pigs with high and low number of embryos, and whether these differences in gene expression might affect embryo implantation. Experimental pig groups (n = 24) for high and low number of embryos were prepared by altering the number of eggs ovulated in pre-pubertal gilts treated with 1...
May 8, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29740277/hedonic-eating-and-the-delicious-circle-from-lipid-derived-mediators-to-brain-dopamine-and-back
#10
REVIEW
Roberto Coccurello, Mauro Maccarrone
Palatable food can be seductive and hedonic eating can become irresistible beyond hunger and negative consequences. This is witnessed by the subtle equilibrium between eating to provide energy intake for homeostatic functions, and reward-induced overeating. In recent years, considerable efforts have been devoted to study neural circuits, and to identify potential factors responsible for the derangement of homeostatic eating toward hedonic eating and addiction-like feeding behavior. Here, we examined recent literature on "old" and "new" players accountable for reward-induced overeating and possible liability to eating addiction...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29736023/mc4r-agonism-promotes-durable-weight-loss-in-patients-with-leptin-receptor-deficiency
#11
Karine Clément, Heike Biebermann, I Sadaf Farooqi, Lex Van der Ploeg, Barbara Wolters, Christine Poitou, Lia Puder, Fred Fiedorek, Keith Gottesdiener, Gunnar Kleinau, Nicolas Heyder, Patrick Scheerer, Ulrike Blume-Peytavi, Irina Jahnke, Shubh Sharma, Jacek Mokrosinski, Susanna Wiegand, Anne Müller, Katja Weiß, Knut Mai, Joachim Spranger, Annette Grüters, Oliver Blankenstein, Heiko Krude, Peter Kühnen
Genetic defects underlying the melanocortin-4 receptor (MC4R) signaling pathway lead to severe obesity. Three severely obese LEPR-deficient individuals were administered the MC4R agonist setmelanotide, resulting in substantial and durable reductions in hyperphagia and body weight over an observation period of 45-61 weeks. Compared to formerly developed and tested MC4R agonists, setmelanotide has the unique capability of activating nuclear factor of activated T cell (NFAT) signaling and restoring function of this signaling pathway for selected MC4R variants...
May 7, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29732984/knockout-of-trpv1-exacerbates-left-ventricular-diastolic-dysfunction-induced-by-a-high-fat-diet-in-mice
#12
Beihua Zhong, Jack Rubinstein, Shuangtao Ma, Donna H Wang
BACKGROUND: Transient receptor potential vanilloid 1 (TRPV1) channels in sensory nerves have anti-oxidative properties and counteract obesity and diabetes that are associated with diastolic dysfunction with preserved ejection fraction. We tested the hypothesis that TRPV1 knockout exacerbates high-fat diet (HFD)-induced glucose intolerance and diastolic dysfunction. METHOD: Trpv1-/- and wild-type (WT) mice were fed chow diet or HFD for 20 weeks. Then, we performed the intraperitoneal glucose tolerance test, measured the heart function through transthoracic echocardiography and Langendorff heart perfusion system, analyzed cardiac histology, and measured the myocardial superoxide production and the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases...
May 3, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29731817/leptin-attenuates-the-growth-of-rabbit-mesenchymal-stem-cells-via-the-extracellular-signal-regulated-kinase-signaling-pathway
#13
Liping Su, Qiao Qiao, Ruifeng Li, Huiguang Wu
When stimulated, mesenchymal stem cells (MSCs) may differentiate into chondroblasts, adipocytes or osteoblasts. Leptin is an adipocyte-derived hormone, which regulates food intake and glucose homeostasis. The aim of the present study was to identify the potential role of mitogen-activated protein kinase in the leptin-induced growth of rabbit bone MSCs (rBMSCs). Various concentrations of leptin were used to culture rBMSCs and the viability of cells was observed as well as alterations in the phosphorylation state of extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase and p38...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29731737/lh-21-a-peripheral-cannabinoid-receptor-1-antagonist-exerts-favorable-metabolic-modulation-including-antihypertensive-effect-in-kkay-mice-by-regulating-inflammatory-cytokines-and-adipokines-on-adipose-tissue
#14
Ziqi Dong, Hui Gong, Yadan Chen, Hong Wu, Jun Wu, Yinghong Deng, Xinmao Song
Patients with obesity are susceptible to hypertension and diabetes. Over-activation of cannabinoid receptor 1 (CB1 R) in adipose tissue is proposed in the pathophysiology of metabolic disorders, which led to the metabolic dysfunction of adipose tissue and deregulated production and secretion of adipokines. In the current study, we determined the impact of LH-21, a representative peripheral CB1 R antagonist, on the obesity-accompanied hypertension and explored the modulatory action of LH-21 on the adipose tissue in genetically obese and diabetic KKAy mice...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29731242/therapeutic-effects-of-the-allosteric-protein-tyrosine-phosphatase-1b-inhibitor-ky-226-on-experimental-diabetes-and-obesity-via-enhancements-in-insulin-and-leptin-signaling-in-mice
#15
Yuma Ito, Masaki Fukui, Mamoru Kanda, Ko Morishita, Yoshimichi Shoji, Tatsuya Kitao, Eiichi Hinoi, Hiroaki Shirahase
The anti-diabetic and anti-obesity effects of the allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide (KY-226) were pharmacologically evaluated. KY-226 inhibited human PTP1B activity (IC50  = 0.28 μM), but did not exhibit peroxisome proliferator-activated receptor γ (PPARγ) agonist activity. In rodent preadipocytes (3T3-L1), KY-226 up to 10 μM had no effects on adipocyte differentiation, whereas pioglitazone, a PPARγ agonist, markedly promoted it...
March 6, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29728855/influence-of-moringa-oleifera-extract-vitamin-c-and-sodium-bicarbonate-on-heat-stress-induced-hsp70-expression-and-cellular-immune-response-in-rabbits
#16
Mahmoud Abdel-Latif, Thabet Sakran, Yasser K Badawi, Doaa S Abdel-Hady
The current study aimed to test the effect of Moringa oleifera extract (MOE), vitamin (Vit) C, and sodium bicarbonate (NaHCO3 ) on heat stress (HS)-induced alterations in rabbits. Five groups of rabbits were designed as control, HS, HS + MOE, HS + Vit C, and HS + NaHCO3 . HS groups were exposed to high temperatures, while treatments were given in drinking water for 6 weeks. Levels of blood cortisol, leptin, IFN-γ, TNF-α, and IL-10 were assayed using ELISA, while adrenaline was assayed calorimetrically...
May 4, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29723298/oral-administration-of-short-chain-fatty-acids-could-attenuate-fat-deposition-of-pigs
#17
A R Jiao, H Diao, B Yu, J He, J Yu, P Zheng, Z Q Huang, Y H Luo, J Q Luo, X B Mao, D W Chen
Short chain fatty acids (SCFAs) are the main products of indigestible carbohydrates that are fermented by microbiota in the hindgut. This study was designed to investigate the effects of oral SCFAs administration on the lipid metabolism of weaned pigs. A total of 21 barrows were randomly allocated into three groups, including control group (orally infused with 200 mL physiological saline per day), low dose SCFAs group (orally infused with 200 mL SCFAs containing acetic acid 20.04 mM, propionic acid 7.71 mM and butyric acid 4...
2018: PloS One
https://www.readbyqxmd.com/read/29723152/-the-role-of-single-nucleotide-polymorphisms-in-gipr-gene-in-the-changes-of-secretion-in-hormones-and-adipokines-in-patients-with-obesity-with-type-2-diabetes
#18
D A Skuratovskaia, M A Vulf, E V Kirienkova, N I Mironyuk, P A Zatolokin, L S Litvinova
The relationship between the rs2302382, rs8111428 and Glu354Gln (rs1800437) polymorphisms in GIPR (glucosedependent insulinotropic polypeptide receptor) gene and plasma levels of mediators involved in the regulation of carbohydrate metabolism in obese patients with type 2 diabetes (before and after a test breakfast) was investigated. The contribution of polymorphic variants of rs2302382, rs8111428 in GIPR gene in the predisposition to type 2 diabetes in individuals belonging to the Slavic population of Russia was found...
March 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29721071/adipocyte-derived-exosomal-mir-27a-induces-insulin-resistance-in-skeletal-muscle-through-repression-of-ppar%C3%AE
#19
Yang Yu, Hongwei Du, Shengnan Wei, Linjing Feng, Junnan Li, Fan Yao, Ming Zhang, Grant M Hatch, Li Chen
The mechanism by which adipocyte-derived endocrine factors promote insulin resistance in skeletal muscle are not fully understood. MiR-27a is highly expressed in sera of obese individuals with prediabetes and T2DM, and mainly derived by adipose tissues. Thus, miR-27a secreted into circulation by adipose tissue may regulate insulin resistance in skeletal muscle. Methods: The association between miR-27a and insulin resistance in skeletal muscle was determined in obese children, high-fat diet-induced miR-27a knockdown obese mice, db/db mice and C2C12 cells overexpressing miR-27a...
2018: Theranostics
https://www.readbyqxmd.com/read/29720894/pleiotropic-associations-of-rarres2-gene-variants-and-circulating-chemerin-levels-potential-roles-of-chemerin-involved-in-the-metabolic-and-inflammation-related-diseases
#20
Leay-Kiaw Er, Semon Wu, Lung-An Hsu, Ming-Sheng Teng, Yu-Ching Sun, Yu-Lin Ko
Chemerin, an adipokine and inflammatory mediator, is associated with metabolic, inflammation- and immune-mediated diseases. The genetic, clinical, and biomarker correlates of circulating chemerin levels have not been completely elucidated. We analyzed the determinants and correlates of retinoic acid receptor responder 2 ( RARRES2 ; encoding chemerin) gene variants and chemerin levels in the Taiwanese population. In total, 612 individuals were recruited. Clinical and metabolic phenotypes, 13 inflammatory markers, 5 adipokines, and 6 single-nucleotide polymorphisms (SNPs) covering the RARRES2 region were analyzed...
2018: Mediators of Inflammation
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