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https://www.readbyqxmd.com/read/29143717/white-matter-abnormalities-in-22q11-2-deletion-syndrome-patients-showing-cognitive-decline
#1
Jasper Olivier Nuninga, Marc Marijn Bohlken, Sanne Koops, Ania M Fiksinski, René C W Mandl, Elemi J Breetvelt, Sasja N Duijff, René S Kahn, Iris E C Sommer, Jacob A S Vorstman
BACKGROUND: Decline in cognitive functioning precedes the first psychotic episode in the course of schizophrenia and is considered a hallmark symptom of the disorder. Given the low incidence of schizophrenia, it remains a challenge to investigate whether cognitive decline coincides with disease-related changes in brain structure, such as white matter abnormalities. The 22q11.2 deletion syndrome (22q11DS) is an appealing model in this context, as 25% of patients develop psychosis. Furthermore, we recently showed that cognitive decline also precedes the onset of psychosis in individuals with 22q11DS...
November 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29129510/increase-in-serum-hdl-level-is-associated-with-less-negative-symptoms-after-one-year-of-antipsychotic-treatment-in-first-episode-psychosis
#2
Priyanthi B Gjerde, Ingrid Dieset, Carmen Simonsen, Eva Z Hoseth, Trude Iversen, Trine V Lagerberg, Siv Hege Lyngstad, Ragni H Mørch, Silje Skrede, Ole A Andreassen, Ingrid Melle, Vidar M Steen
BACKGROUND: A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. METHODS: A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project...
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29128326/cognitive-remediation-can-improve-negative-symptoms-and-social-functioning-in-first-episode-schizophrenia-a-randomized-controlled-trial
#3
Joseph Ventura, Kenneth L Subotnik, Denise Gretchen-Doorly, Laurie Casaus, Michael Boucher, Gerhard S Hellemann, Keith H Nuechterlein
BACKGROUND: Meta-analyses have reported that the effects of cognitive remediation might go beyond improvement in cognition to include unexpected benefits for schizophrenia patients such as negative symptom reduction and improvements in functioning. In addition, some evidence indicated that these potentially beneficial effects are also present in the initial course of schizophrenia, but work in this area is still developing. METHOD: A RCT compared Cognitive Remediation (CR) to Healthy Behaviors Training (HBT) in 80 patients (78% male) with a mean age of 21...
November 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#4
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29126609/meta-analysis-of-adult-height-and-birth-length-in-schizophrenia
#5
Keely Latham, Brian Kirkpatrick
OBJECTIVE: As a group, people with schizophrenia have a number of subtle anatomical abnormalities as well as physiological abnormalities that precede antipsychotic treatment. Some studies have also found shorter birth length or shorter adult height in people with schizophrenia compared to control subjects. We performed a systematic review and meta-analysis of studies of birth length and adult height in schizophrenia, following PRISMA guidelines (Prospero Registration # CRD42016043718)...
November 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29121974/a-randomised-double-blind-placebo-controlled-trial-of-minocycline-and-or-omega-3-fatty-acids-added-to-treatment-as-usual-for-at-risk-mental-states-nayab-study-protocol
#6
Inti Qurashi, Imran B Chaudhry, Ameer B Khoso, Sana Farooque, Steve Lane, Mohammad Omair Husain, Simon Chu, Jane Sarginson, Munir Hamarani, Haider A Naqvi, Bushra Razzaque, Fareed A Minhas, Alison R Yung, J F W Deakin, Nusrat Husain
BACKGROUND: The at-risk mental state (ARMS) describes individuals at high risk of developing schizophrenia or psychosis. The use of antipsychotics in this population is not supported, because most individuals with ARMS are unlikely to develop psychosis. Anti-inflammatory treatments and polyunsaturated fatty acids (PUFAs) may have some beneficial effects in the treatment of ARMS. There have been no controlled clinical trials in which researchers have investigated the use of minocycline for ARMS and no trials involving PUFAs in combination with other proposed treatments...
November 9, 2017: Trials
https://www.readbyqxmd.com/read/29121595/from-the-psychosis-prodrome-to-the-first-episode-of-psychosis-no-evidence-of-a-cognitive-decline
#7
Ricardo E Carrión, Deborah J Walder, Andrea M Auther, Danielle McLaughlin, Heather O Zyla, Steven Adelsheim, Roderick Calkins, Cameron S Carter, Bentson McFarland, Ryan Melton, Tara Niendam, J Daniel Ragland, Tamara G Sale, Stephan F Taylor, William R McFarlane, Barbara A Cornblatt
Cognitive deficits have an important role in the neurodevelopment of schizophrenia and other psychotic disorders. However, there is a continuing debate as to whether cognitive impairments in the psychosis prodrome are stable predictors of eventual psychosis or undergo a decline due to the onset of psychosis. In the present study, to determine how cognition changes as illness emerges, we examined baseline neurocognitive performance in a large sample of helping-seeking youth ranging in clinical state from low-risk for psychosis through individuals at clinical high-risk (CHR) for illness to early first-episode patients (EFEP)...
October 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29118723/inflammation-stress-response-and-redox-dysregulation-biomarkers-clinical-outcomes-and-pharmacological-implications-for-psychosis
#8
REVIEW
Stefania Schiavone, Luigia Trabace
In recent years, several studies claiming the finding of a specific biomarker for the identification of the "high-risk state" to develop psychosis, first psychotic episode, as well as the prediction of the individual response to antipsychotics have been published. Together with genetic reports, numerous publications in this field have been focused on inflammation and stress response blood biomarkers, as well as on indicators of redox dysregulation. In this review, we focus on human studies found in PubMed from January 1(st) 2010 to January 31(st) 2017, describing the clinical use of these biomarkers to detect the "premorbid" psychotic state and early phases of the disease...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29116670/predictive-capacity-of-prodromal-symptoms-in-first-episode-psychosis-of-recent-onset
#9
Ana Barajas, Trinidad Pelaez, Olga González, Judith Usall, Raquel Iniesta, Maria Arteaga, Chris Jackson, Iris Baños, Bernardo Sánchez, Montserrat Dolz, Jordi E Obiols, Josep M Haro, Susana Ochoa
BACKGROUND: Both the nature and number of a wide range of prodromal symptoms have been related to the severity and type of psychopathology in the psychotic phase. However, at present there is an incomplete picture focused mainly on the positive pre-psychotic dimension. AIM: To characterize the prodromal phase retrospectively, examining the number and nature of prodromal symptoms as well as their relationship with psychopathology at the onset of first-episode psychosis...
November 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29110334/frontotemporal-dementia-with-trans-activation-response-dna-binding-protein-43-presenting-with-catatonic-syndrome
#10
Ryohei Watanabe, Ito Kawakami, Mitsumoto Onaya, Shinji Higashi, Nobutaka Arai, Haruhiko Akiyama, Masato Hasegawa, Tetsuaki Arai
Catatonia is a clinical syndrome characterized by symptoms such as immobility, mutism, stupor, stereotypy, echophenomena, catalepsy, automatic obedience, posturing, negativism, gegenhalten and ambitendency. This syndrome occurs mostly in mood disorder and schizophrenic patients, and is related to neuronal dysfunction involving the frontal lobe. Some cases of frontotemporal dementia (FTD) with catatonia have been reported, but these cases were not examined by autopsy. Here, we report on a FTD case which showed catatonia after the first episode of brief psychotic disorder...
November 7, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29107832/impaired-action-self-monitoring-and-cognitive-confidence-among-ultra-high-risk-for-psychosis-and-first-episode-psychosis-patients
#11
Ł Gawęda, E Li, S Lavoie, T J Whitford, S Moritz, B Nelson
BACKGROUND: Self-monitoring biases and overconfidence in incorrect judgments have been suggested as playing a role in schizophrenia spectrum disorders. Little is known about whether self-monitoring biases may contribute to early risk factors for psychosis. In this study, action self-monitoring (i.e., discrimination between imagined and performed actions) was investigated, along with confidence in judgments among ultra-high risk (UHR) for psychosis individuals and first-episode psychosis (FEP) patients...
September 22, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29092669/the-clinical-impact-of-a-positive-family-history-of-psychosis-or-mental-illness-in-psychotic-and-non-psychotic-mentally-ill-adolescents
#12
Saeeda Paruk, Khatija Jhazbhay, Keshika Singh, Benn Sartorius, Jonathan K Burns
BACKGROUND: A family history of psychosis is associated with negative clinical characteristics of psychosis. AIM: We aimed to determine the relationship between a family history (in first-degree relatives) of psychosis (FHP) or of any mental illness (FHM), and the clinical features (including cannabis use) of first episode early onset psychosis (EOP). METHOD: Forty-five adolescents with first episode EOP presenting to psychiatric services were assessed by clinical interview with the following tools: socio-demographic questionnaire, Positive and Negative Syndrome Scale (PANSS), Symptom Onset in Schizophrenia (SOS) inventory, and the World Health Organisation's (WHO) Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) for cannabis misuse...
November 2, 2017: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29076286/social-inclusion-and-its-interrelationships-with-social-cognition-and-social-functioning-in-first-episode-psychosis
#13
Andrew Gardner, Sue M Cotton, Kelly Allott, Kate M Filia, Robert Hester, Eóin Killackey
AIM: People with psychosis are at risk of social exclusion. Research is needed in this area due to the lack of direct measurement of social inclusion, which becomes salient in adolescence and is relevant to first-episode psychosis (FEP; the onset of which typically occurs during or shortly after adolescence). Social inclusion may be impacted by impaired social cognition and social functioning, which are related features observed in psychosis. The aim of this study was to explore interrelationship(s) between social cognition, social functioning and social inclusion in FEP while controlling for symptomatology (positive, negative and depressive symptoms) and demographic characteristics...
October 27, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29072191/compulsory-admissions-in-southwest-greece-2010-2011-a-descriptive-report
#14
M Skokou, P Gouma, P Gourzis
Compulsory admissions represent a significant proportion of psychiatric hospitalizations. A wide variation seems to exist internationally regarding legal frameworks, administrative procedures, detention rates and clinical practice. The aim of the present study is to describe qualitative and quantitative features of compulsory admissions in a large administrative area in southwest Greece, in order to identify targets for future research and possible remediation. Involuntary assessments and admissions in the Department of Psychiatry of the University Hospital of Patras were retrospectively assessed, during a 12-month period, for demographic features and data regarding legal procedures...
July 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29066260/prolactin-monitoring-in-first-episode-psychotic-patients
#15
David N Osser
No abstract text is available yet for this article.
October 21, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29055258/cognitive-functioning-in-first-episode-bipolar-i-disorder-patients-with-and-without-history-of-psychosis
#16
Chakrabarty Trisha, Alamian Golnoush, Kozicky Jan-Marie, Ivan J Torres, Lakshmi N Yatham
BACKGROUND: Psychosis in bipolar I disorder (BDI) has been associated with increased cognitive dysfunction, which may relate to poorer functional outcomes. However, it is not known whether cognition differs between BDI patients with (BDP+) or without (BDP-) history of psychosis early in the disease course, or if it is impacted by the presence of mood congruent (MCP) versus incongruent (MIC) psychotic features. We compare cognition between these groups in BDI patients recently recovered from first episode of mania...
October 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29052952/factor-structure-of-the-cannabis-experiences-questionnaire-in-a-first-episode-psychosis-sample
#17
Michael L Birnbaum, Sean D Cleary, Claire Ramsay Wan, Luca Pauselli, Michael T Compton
AIM: The Cannabis Experiences Questionnaire (CEQ) was developed to measure the subjective experiences of cannabis use both during and after intoxication. Despite the need to better understand the nature of the complex and significant relationship between cannabis use and early psychosis, this questionnaire has rarely been used in individuals with first-episode psychosis. METHODS: We conducted a set of factor analyses using CEQ data from 194 first-episode psychosis patients who used cannabis in order to uncover the underlying factor structure of the questionnaire and thus the overarching types of psychological experiences during/after using cannabis in young people with psychotic disorders...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29052948/association-of-participant-preferences-on-work-and-school-participation-after-a-first-episode-of-psychosis
#18
Alexandra de Waal, Lisa B Dixon, Jennifer L Humensky
AIM: To explore baseline ratings of importance (ROI) across life domains for participants in the Recovery After an Initial Schizophrenia Episode Connection Program (RAISE CP), and investigate whether ratings were correlated with intervention outcomes over time. METHODS: At baseline, 63 participants rated the importance of reducing symptoms, side-effects, confusion, increasing energy and school/work functioning and improving social relations. ROIs were examined in relation to work/school participation (n = 41) and occupational functioning (n = 37) after 12 months...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29050531/anti-nmda-receptor-encephalitis-still-unknown-and-underdiagnosed-by-physicians-and-especially-by-psychiatrists
#19
Tine Hermans, Patrick Santens, Celine Matton, Kristine Oostra, Gunter Heylens, Sarah Herremans, Gilbert M D Lemmens
Anti-NMDA receptor encephalitis is an autoimmune disorder confirmed by the presence of antibodies against the NMDA-receptor in serum or CSF. This case report describes a young woman with anti-NMDA receptor encephalitis, who presented with prominent psychiatric symptoms. There was a crucial delay in diagnosis and necessary treatment due to the fact that the clinical presentation was diagnosed and treated as a first psychotic episode. Physicians and especially psychiatrists, should consider the possibility of an autoimmune encephalitis in their differential diagnosis in every new onset psychotic episode with rapid progression, the presence of pathognomonic orofacial dyskinesia, the lack of psychiatric history, and the non-responding to psychopharmacological treatment...
October 19, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29049482/a-test-of-the-transdiagnostic-dopamine-hypothesis-of-psychosis-using-positron-emission-tomographic-imaging-in-bipolar-affective-disorder-and-schizophrenia
#20
Sameer Jauhar, Matthew M Nour, Mattia Veronese, Maria Rogdaki, Ilaria Bonoldi, Matilda Azis, Federico Turkheimer, Philip McGuire, Allan H Young, Oliver D Howes
Importance: The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective disorder and schizophrenia, in line with the research domain criteria approach. However, this hypothesis has not been directly examined in individuals diagnosed with bipolar disorder with psychosis. Objectives: To test whether dopamine synthesis capacity is elevated in bipolar disorder with psychosis and how this compares with schizophrenia and matched controls and to examine whether dopamine synthesis capacity is associated with psychotic symptom severity, irrespective of diagnostic class...
October 11, 2017: JAMA Psychiatry
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