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first episode psychotic

Alexander Sumich, Anthony Harris, Thomas Whitford, Daniel Hermens, Nadja Heym, John Anderson, Claire Bloxsom, Fraenze Kibowski, Veena Kumari
OBJECTIVE: Right frontal function, as indicated by the N200 component of the event-related potential during target detection, has previously been associated with excitement (excitement, impulsivity, hostility, uncooperativeness) in men with a long-term diagnosis of schizophrenia. The current study investigated excitement in relation to N200 in men who had recently experienced their first episode of psychosis. SUBJECTS AND METHODS: Twenty men who had recently suffered their first psychotic episode underwent a clinical interview and auditory oddball task...
March 2018: Psychiatria Danubina
Stefania Schiavone, Luigia Trabace
Recent evidence highlighted a pathogenetic link between redox dysregulation and the early stages of psychosis. Indeed, an increasing number of studies have pointed toward an association between oxidative stress, both at central and peripheral levels, and first psychotic episode. Moreover, basal low antioxidant capacity has been shown to directly correlate with cognitive impairment in the early onset of psychosis. In this context, the possibility to use antioxidant compounds in first psychotic episode, especially as supplementation to antipsychotic therapy, has become the focus of numerous investigations on rodents with the aim to translate data on the possible effects of antioxidant therapies to large populations of patients, with a diagnosis of the first psychotic episode...
March 14, 2018: CNS Neuroscience & Therapeutics
Kristen Thien, Meghan Bowtell, Scott Eaton, Melissa Bardell-Williams, Linglee Downey, Aswin Ratheesh, Patrick McGorry, Brian O'Donoghue
BACKGROUND: The superior efficacy of clozapine in treatment resistant schizophrenia has been clearly demonstrated, yet there are often delays in the commencement of clozapine. In this study, we aimed to determine; the proportion of young people with a first episode of psychosis (FEP) who would be considered eligible for clozapine treatment, the theoretical delay in commencing clozapine and to compare the outcomes of those treated with clozapine to those who were eligible but not treated with clozapine...
March 8, 2018: Schizophrenia Research
Virginie-Anne Chouinard, David C Henderson, Chiara Dalla Man, Linda Valeri, Brianna E Gray, Kyle P Ryan, Aaron M Cypess, Claudio Cobelli, Bruce M Cohen, Dost Öngür
Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin sensitivity in first-episode psychosis (FEP) patients and unaffected siblings, compared to healthy individuals, using a physiological-based model and comprehensive assessment battery. Twenty-two unaffected siblings, 18 FEP patients, and 15 healthy unrelated controls were evaluated using a 2-h oral glucose tolerance test (OGTT), with 7 samples of plasma glucose and serum insulin concentration measurements...
March 9, 2018: Molecular Psychiatry
Chunzhen Tan, Edimansyah Abdin, Wilfred Liang, Lye Yin Poon, Ngar Yee Poon, Swapna Verma
AIM: Early intervention programmes for first episode psychosis (FEP) aim to reduce the duration of untreated psychosis (DUP) and improve functional outcomes. The sustained maintenance of improved outcomes depends largely on patients' adherence to prescribed treatment. This paper examines the prevalence of non-adherence in a cohort of patients with FEP and the sociodemographic and clinical factors associated with non-adherent behaviour. METHODS: The sample included consecutive patients accepted from 2007 to 2012 into the Early Psychosis Intervention Programme (EPIP) in Singapore...
March 9, 2018: Early Intervention in Psychiatry
Karoline Krane-Gartiser, Andreas Asheim, Ole Bernt Fasmer, Gunnar Morken, Arne E Vaaler, Jan Scott
BACKGROUND: Actigraphy could be an objective alternative to clinical ratings of motor activity in bipolar disorder (BD), which is of importance now that increased activity and energy are added as cardinal symptoms of (hypo)mania in the DSM-5 and commonly used rating scales give inadequate information about motor symptoms. To date, most actigraphy studies have been conducted in groups and/or used mean activity levels as the variable of interest. The novelty of this case series is therefore to indicate the potential of actigraphy and non-parametric analysis as an objective and personalized marker of intra-individual activity patterns in different phases of BD...
March 7, 2018: International Journal of Bipolar Disorders
H Rebhi, R Damak, W Cherif, S Ellini, M Cheour, F Ellouze
OBJECTIVES: The duration of untreated psychosis is defined as the interval between the first psychotic symptoms and the first starting treatment. The duration of untreated psychosis is highly variable but often prolonged and may be influenced by several factors. Some studies suggested that duration of untreated psychosis is associated with poor outcome. The objectives of this study were to assess the duration of untreated psychosis in a Tunisian cohort and its impact on the quality of life and the cognitive functions of schizophrenic patients at 2 years...
February 27, 2018: L'Encéphale
Nicholas J K Breitborde, Letitia Labrecque, Aubrey Moe, Tad Gary, Mike Meyer
Growing evidence suggests that specialized, multicomponent intervention provided early in the course of a psychotic disorder may have a positive effect in ameliorating the morbidity and mortality associated with these disorders. This column describes the development of the Institute for Mental Health Research Early Psychosis Intervention Center, which leverages the unique strengths of a community and academic partnership to provide such specialty care in a youth-friendly, stigma-free environment. Since it opened in 2016, the program has had numerous successes, including securing increased reimbursements rates and performance-based incentives for the treatment of first-episode psychosis...
March 1, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
Wing Chung Chang, Vivian Wing Yan Kwong, Philip Or Chi Fai, Emily Sin Kei Lau, Gloria Hoi Kei Chan, Olivia Tsz Ting Jim, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen
OBJECTIVE: Functional remission represents an intermediate functional milestone toward recovery. Differential relationships of negative symptom sub-domains with functional remission in first-episode psychosis are understudied. We aimed to examine rate and predictors of functional remission in people with first-episode psychosis in the context of a 3-year follow-up of a randomized controlled trial comparing 1-year extension of early intervention (i.e. 3-year early intervention) with step-down psychiatric care (i...
February 1, 2018: Australian and New Zealand Journal of Psychiatry
Maximus Berger, Robert-Paul Juster, Sabine Westphal, G Paul Amminger, Bernhard Bogerts, Kolja Schiltz, Sabine Bahn, Johann Steiner, Zoltan Sarnyai
Current pathophysiological models of schizophrenia suggest that stress contributes to the etiology and trajectory of the disorder. We investigated if allostatic load (AL), an integrative index of neuroendocrine, immune and metabolic dysregulation in response to chronic stress, is elevated in patients with schizophrenia (SCZ) and first-episode psychosis (FEP) and related to psychotic symptoms and social and occupational functioning. Additionally, we assessed the temporal dynamics of AL in response to treatment with second-generation antipsychotics...
February 5, 2018: Psychoneuroendocrinology
Donal O'Keeffe, Ann Sheridan, Aine Kelly, Roisin Doyle, Kevin Madigan, Elizabeth Lawlor, Mary Clarke
Little is known about how recovery oriented policy and legislative changes influence service users' perceptions of mental health care over time. Although the recovery approach is endorsed in many countries, qualitative research examining its impact on service use experiences has been lacking. This study aimed to explore this impact as well as experiences of service utilisation and suggestions for change with people diagnosed with a First Episode Psychosis between 1995 and 1999. Participants had used services during the 10 year period prior to, and 10 years post, policy and legislative shifts to the recovery approach...
February 6, 2018: Administration and Policy in Mental Health
Jeong Seok Seo, Won-Myong Bahk, Hee Ryung Wang, Young Sup Woo, Young-Min Park, Jong-Hyun Jeong, Won Kim, Se-Hoon Shim, Jung Goo Lee, Duk-In Jon, Kyung Joon Min
Objective: In 2002, the Korean Society for Affective Disorders developed the guidelines for the treatment of major depressive disorder (MDD), and revised it in 2006 and 2012. The third revision of these guidelines was undertaken to reflect advances in the field. Methods: Using a 44-item questionnaire, an expert consensus was obtained on pharmacological treatment strategies for MDD 1) without or 2) with psychotic features, 3) depression subtypes, 4) maintenance, 5) special populations, 6) the choice of an antidepressant (AD) regarding safety and adverse effects, and 7) non-pharmacological biological therapies...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Wing Chung Chang, Angel On Ki Chu, Vivian Wing Yan Kwong, Corine Sau Man Wong, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen
BACKGROUND: Functional impairment is prevalent in patients with first-episode psychosis (FEP). Longitudinal course of functioning in the early stage of psychotic illness is under-studied. In this report, we aimed to investigate the patterns and baseline predictors of social-occupational functional trajectories over 3 years, utilizing growth mixture modeling (GMM) analysis, in a large representative Chinese young FEP cohort in Hong Kong. METHOD: Six hundred seventeen consecutive patients aged 15-25 years presenting with first-episode non-affective psychosis to a specialized early intervention service were studied...
January 27, 2018: Schizophrenia Research
Aengus ÓConghaile, Diane L Smedberg, Ah L Shin, Lynn E DeLisi
AIMS/OBJECTIVES/BACKGROUND: Post-traumatic stress disorder (PTSD) is a leading cause of morbidity among military veterans, with up to one-in-five individuals with PTSD also having psychotic symptoms. The current study was designed to determine the association between a known family history of psychiatric illness and risk of developing psychosis in patients with PTSD. METHODS: Retrospective medical record review was performed on a cohort study of 414 consecutive individuals admitted to the Veteran Administration in 2014 with a diagnosis of military-related PTSD, but without a prior diagnosis of a psychotic disorder...
January 30, 2018: Psychiatric Genetics
Buranee Kanchanatawan, Supaksorn Thika, Sunee Sirivichayakul, André F Carvalho, Michel Geffard, Michael Maes
The depression, anxiety and physiosomatic symptoms (DAPS) of schizophrenia are associated with negative symptoms and changes in tryptophan catabolite (TRYCAT) patterning. The aim of this study is to delineate the associations between DAPS and psychosis, hostility, excitation, and mannerism (PHEM) symptoms, cognitive tests as measured using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) and IgA/IgM responses to TRYCATs. We included 40 healthy controls and 80 participants with schizophrenia...
January 29, 2018: Neurotoxicity Research
Ragnar Nesvåg, Jørgen G Bramness, Marte Handal, Ingeborg Hartz, Vidar Hjellvik, Svetlana Skurtveit
BACKGROUND: Antipsychotic drug use among children and adolescents is increasing, and there is growing concern about off-label use and adverse effects. The present study aims to investigate the incidence, psychiatric co-morbidity and pharmacological treatment of severe mental disorder in Norwegian children and adolescents. METHODS: We obtained data on mental disorders from the Norwegian Patient Registry on 0-18 year olds who during 2009-2011 were diagnosed for the first time with schizophrenia-like disorder (International Classification of Diseases, 10th revision codes F20-F29), bipolar disorder (F30-F31), or severe depressive episode with psychotic symptoms (F32...
January 20, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Elisabeth Frank, Dieter Maier, Juha Pajula, Tommi Suvitaival, Faith Borgan, Markus Butz-Ostendorf, Alexander Fischer, Jarmo Hietala, Oliver Howes, Tuulia Hyötyläinen, Joost Janssen, Heikki Laurikainen, Carmen Moreno, Jaana Suvisaari, Mark Van Gils, Matej Orešič
Psychotic disorders are associated with metabolic abnormalities including alterations in glucose and lipid metabolism. A major challenge in the treatment of psychosis is to identify patients with vulnerable metabolic profiles who may be at risk of developing cardiometabolic co-morbidities. It is established that both central and peripheral metabolic organs use lipids to control energy balance and regulate peripheral insulin sensitivity. The endocannabinoid system, implicated in the regulation of glucose and lipid metabolism, has been shown to be dysregulated in psychosis...
January 17, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
V Moulin, P Golay, J Palix, P S Baumann, M-M Gholamrezaee, A Azzola, J Gasser, K Q Do, L Alameda, P Conus
BACKGROUND: Violent behaviour (VB) occurs in first episode of schizophrenia and can have devastating impact both on victims and patients themselves. A better knowledge of the underlying mechanisms of VB may pave the way to preventive treatments. OBJECTIVES: 1) To explore the nature of the link between impulsivity and VB in early psychosis (EP) patients; 2) To explore the interactions between impulsivity and substance abuse, insight, and positive symptoms, the main dynamic risk factors of VB described to date...
January 17, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Moira C McManus, Robert J Cramer, Maureen Boshier, Muge Akpinar-Elci, Bonnie Van Lunen
Emergency department (ED) utilization has increased due to factors such as admissions for mental health conditions, including suicide and self-harm. We investigate direct and moderating influences on non-emergent ED utilization through the Behavioral Model of Health Services Use. Through logistic regression, we examined correlates of ED use via 2014 New York State Department of Health Statewide Planning and Research Cooperative System outpatient data. Consistent with the primary hypothesis, mental health admissions were associated with emergent use across models, with only a slight decrease in effect size in rural living locations...
January 13, 2018: International Journal of Environmental Research and Public Health
Jacques Besson, Jeremy Grivel, Alexander Tomei, Mélina Andronicos, Daniele Zullino, Gabriel Thorens, Stergios Tsartsalis, Isabelle Gothuey, Monique Séguin
This year, the actuality for addictions in this edition addresses four points. The disease model of addiction is criticized by the cognitive neurosciences which need to consider the agentivity of the persons. Regarding the societal actuality, clinical pharmacology review of cannabidiol presents an update on legal cannabis. The suicidality of excessive gamblers may be prevented specifically. Addiction and first psychotic episodes need an integrated care.
January 10, 2018: Revue Médicale Suisse
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