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https://www.readbyqxmd.com/read/28343286/a-mimic-of-sexually-motivated-homicide-insect-stings-and-heat-exhaustion-in-a-forest
#1
Nancy X Liu, Michael S Pollanen
We report the case a woman who was found dead in a forest. The body was nude and the position of the body suggested a sexually motivated homicide. We concluded that death was not related to homicide, but was related to the conjunction of environmental factors, including insect stings, and acute psychosis. A medicolegal death investigation with postmortem examination was undertaken to determine cause of death. At the scene, the body was supine with legs spread apart and the knees flexed, exposing the external genitalia...
March 25, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28334045/plasma-soluble-l-selectin-in-medicated-patients-with-schizophrenia-and-healthy-controls
#2
Satyajit Mohite, Fang Yang, Pooja A Amin, Giovana Zunta-Soares, Gabriela D Colpo, Laura Stertz, Ajaykumar N Sharma, Gabriel R Fries, Consuelo Walss-Bass, Jair C Soares, Olaoluwa O Okusaga
Immune dysfunction has been implicated in the pathophysiology of schizophrenia. Leukocyte migration to the site of inflammation is a fundamental step of immune response which involves P-, E-, and L-selectins. Elevated selectin levels have been reported in un-medicated first-episode patients with schizophrenia but not in medicated patients with multi-episode schizophrenia. We measured fasting plasma soluble P-, E-, and L-selectin in 39 medicated patients with multi-episode schizophrenia and 19 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28321200/the-importance-of-metamemory-functioning-to-the-pathogenesis-of-psychosis
#3
REVIEW
Sarah Eisenacher, Mathias Zink
Many studies up to date have implied that biases in the metacognition of memory, so called metamemory, contribute to the development and maintenance of positive symptoms in schizophrenia. However, no study exists which has longitudinally followed patients experiencing positive symptoms. The present article therefore reviews cross-sectional studies on retrospective metamemory abilities in participants within different stages of a schizophrenia spectrum disorder, with heterogeneous symptom severities, creating a pseudo-longitudinal overview...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28320164/impact-of-stn-dbs-on-mood-drive-anhedonia-and-risk-of-psychiatric-side-effects-in-the-population-of-pd-patients
#4
Anna Antosik-Wójcińska, Łukasz Święcicki, Monika Dominiak, Emilia Sołtan, Przemyslaw Bieńkowski, Tomasz Mandat
BACKGROUND: DBS is a surgical method of choice for various movement disorders, especially for Parkinson's disease (PD). Many publications showing improvement in motor symptoms and quality of life have been presented while there is little comprehensive research evaluation of the impact of DBS on mental state and psychiatric side-effects. OBJECT: The purpose of this study was to assess the impact of DBS on mood, drive, anhedonia and psychotic symptoms in the group of PD patients...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319786/lower-cardiorespiratory-fitness-is-associated-with-more-time-spent-sedentary-in-first-episode-psychosis-a-pilot-study
#5
Davy Vancampfort, Marc De Hert, Inez Myin-Germeys, Ruud van Winkel, Joseph Firth, Tine Van Damme, Michel Probst
Patients with a psychotic disorder show lower cardiorespiratory fitness and higher mortality rates compared to healthy individuals. The aim of this cross-sectional study was to explore whether in patients with first-episode psychosis a low cardiorespiratory fitness is associated with decreased physical activity and increased sedentary levels. Twenty-nine outpatients (21 men; 22.8±5.1 years) performed a maximal exercise test to assess their maximum oxygen uptake (VO2max), wore a Senswear armband for five consecutive days and were assessed with the Positive and Negative Syndrome Scale...
March 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28294137/relationship-between-duration-of-untreated-psychosis-and-intrinsic-corticostriatal-connectivity-in-patients-with-early-phase-schizophrenia
#6
Deepak K Sarpal, Delbert G Robinson, Christina Fales, Todd Lencz, Miklos Argyelan, Katherine H Karlsgodt, Juan A Gallego, Majnu John, John M Kane, Philip R Szeszko, Anil K Malhotra
Patients with first-episode psychosis experience psychotic symptoms for a mean of up to two years prior to initiation of treatment, and long duration of untreated psychosis (DUP) is associated with poor clinical outcomes. Meanwhile, evidence compiled from numerous studies suggests that longer DUP is not associated with structural brain abnormalities. To date, few studies have examined the relationship between DUP and functional neuroimaging measures. In the present study, we used seed-based resting-state functional connectivity to examine the impact of DUP on corticostriatal circuitry...
March 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28291969/impact-of-stress-response-in-development-of-first-episode-psychosis-in-schizophrenia-an-overview-of-systematic-reviews
#7
Linda Rossini Gajsak, Andrea Gelemanovic, Martina Rojnic Kuzman, Livia Puljak
BACKGROUND: To summarize all available evidence from systematic reviews about the impact of stress response in development of first-episode psychosis (FEP) in schizophrenia. METHODS: An overview of systematic reviews of any type of primary studies was performed. An electronic search of five databases was conducted in February 2017 (CDSR, DARE, Embase, MEDLINE and PsychINFO). Quality of included systematic reviews was assessed using the AMSTAR checklist. RESULTS: Eight systematic reviews were included...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28277310/antipsychotic-medication-and-remission-of-psychotic-symptoms-10years-after-a-first-episode-psychosis
#8
Regitze Sølling Wils, Ditte Resendal Gotfredsen, Carsten Hjorthøj, Stephen F Austin, Nikolai Albert, Rikke Gry Secher, Anne Amalie Elgaard Thorup, Ole Mors, Merete Nordentoft
BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up...
October 27, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/28258794/brain-bioenergetics-and-redox-state-measured-by-31-p-magnetic-resonance-spectroscopy-in-unaffected-siblings-of-patients-with-psychotic-disorders
#9
Virginie-Anne Chouinard, Sang-Young Kim, Linda Valeri, Cagri Yuksel, Kyle P Ryan, Guy Chouinard, Bruce M Cohen, Fei Du, Dost Öngür
BACKGROUND: Brain bioenergetic anomalies and redox dysregulation have been implicated in the pathophysiology of psychotic disorders. The present study examined brain energy-related metabolites and the balance between nicotinamide adenine dinucleotide metabolites (oxidized NAD+ and reduced NADH) using (31)P-magnetic resonance spectroscopy ((31)P-MRS) in unaffected siblings, compared to first episode psychosis (FEP) patients and healthy controls. METHODS: 21 unaffected siblings, 32 FEP patients (including schizophrenia spectrum and affective psychoses), and 21 controls underwent (31)P-MRS in the frontal lobe (6×6×4cm(3)) on a 4T MR scanner, using custom-designed dual-tuned surface coil with outer volume suppression...
March 1, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28254958/quetiapine-v-lithium-in-the-maintenance-phase-following-a-first-episode-of-mania-randomised-controlled-trial
#10
Michael Berk, Rothanthi Daglas, Orwa Dandash, Murat Yücel, Lisa Henry, Karen Hallam, Craig Macneil, Melissa Hasty, Christos Pantelis, Brendan P Murphy, Linda Kader, Saji Damodaran, Michael T H Wong, Philippe Conus, Aswin Ratheesh, Patrick D McGorry, Sue M Cotton
BackgroundLithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their efficacy compares with each other.AimsTo investigate the differential effect of lithium and quetiapine on symptoms of depression, mania, general functioning, global illness severity and quality of life in patients with recently stabilised first-episode mania.MethodMaintenance trial of patients with first-episode mania stabilised on a combination of lithium and quetiapine, subsequently randomised to lithium or quetiapine monotherapy (up to 800 mg/day) and followed up for 1 year...
March 2, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28235557/multidisciplinary-consensus-on-the-therapeutic-recommendations-for-iatrogenic-hyperprolactinemia-secondary-to-antipsychotics
#11
REVIEW
Ángel-Luis Montejo, Celso Arango, Miquel Bernardo, José-Luis Carrasco, Benidicto Crespo-Facorro, Juan-Jesús Cruz, Javier Del Pino-Montes, Miguel-Alfonso García-Escudero, Clemente García-Rizo, Ana González-Pinto, Ana-Isabel Hernández, Manuel Martín-Carrasco, Fermín Mayoral-Cleries, Jaqueline Mayoral-van Son, María-Teresa Mories, Isabella Pachiarotti, Jesús Pérez, Salvador Ros, Eduard Vieta
Hyperprolactinemia is an underappreciated/unknown adverse effects of antipyschotics. The consequences of hyperprolactinemia compromise therapeutic adherence and can be serious. We present the consensus recommendations made by a group of experts regarding the management of antipsychotic-induced hyperprolactinemia. The current consensus was developed in 3 phases: 1, review of the scientific literature; 2, subsequent round table discussion to attempt to reach a consensus among the experts; and 3, review by all of the authors of the final conclusions until reaching a complete consensus...
February 21, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28214175/the-traumatic-experience-of-first-episode-psychosis-a-systematic-review-and-meta-analysis
#12
Rebecca Rodrigues, Kelly K Anderson
INTRODUCTION: A psychotic episode may be sufficiently traumatic to induce symptoms of post-traumatic stress disorder (PTSD), which could impact outcomes in first-episode psychosis (FEP). The objectives of this systematic review and meta-analysis were to estimate the prevalence of PTSD symptoms in relation to psychosis in FEP and to identify risk factors for the development of PTSD symptoms. METHODS: We searched electronic databases and conducted manual searching of reference lists and tables of contents to identify relevant studies...
February 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28196549/mental-health-related-stigma-and-pathways-to-care-for-people-at-risk-of-psychotic-disorders-or-experiencing-first-episode-psychosis-a-systematic-review
#13
P C Gronholm, G Thornicroft, K R Laurens, S Evans-Lacko
BACKGROUND: Stigma associated with mental illness can delay or prevent help-seeking and service contact. Stigma-related influences on pathways to care in the early stages of psychotic disorders have not been systematically examined. METHOD: This review systematically assessed findings from qualitative, quantitative and mixed-methods research studies on the relationship between stigma and pathways to care (i.e. processes associated with help-seeking and health service contact) among people experiencing first-episode psychosis or at clinically defined increased risk of developing psychotic disorder...
February 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28185785/can-antibiotics-cause-a-psychosis-case-report-and-review-of-the-literature
#14
Duy Ly, Lynn E DeLisi
It is relatively unknown that some of the possible side effects of antibiotic treatment can be transient psychotic episodes and other encephalopathies such as seizure disorders. Since these are rare events, there have not been many studies about them, nor is there a clear understanding of the underlying basis for these symptoms. This phenomenon was recently brought to our attention by a patient whose case history is discussed here. For the past few years, he has been diagnosed at different times with schizophrenia, schizoaffective disorder, bipolar disorder with psychosis, temporal lobe epilepsy, and psychogenic nonepileptic seizures...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28179063/modelling-gene-environment-interaction-in-first-episodes-of-psychosis
#15
Miguel Bernardo, Miquel Bioque, Bibiana Cabrera, Antonio Lobo, Ana González-Pinto, Laura Pina, Iluminada Corripio, Julio Sanjuán, Anna Mané, Josefina Castro-Fornieles, Eduard Vieta, Celso Arango, Gisela Mezquida, Patricia Gassó, Mara Parellada, Jerónimo Saiz-Ruiz, Manuel J Cuesta, Sergi Mas
INTRODUCTION: Recent research demonstrates the heterogeneous etiology of psychotic disorders, where gen-environment (GxE) interaction plays a key role. Large genetic studies have linked many genetic variants with schizophrenia, but each variant is only associated with a small effect and the GxE interaction contribution has not been evaluated. METHODS: The PEPs Project was designed to carefully collect a large amount of genetic and environmental exposure data of 335 FEP patients and 253 matched healthy controls...
February 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28163856/29-year-old-man-with-multiple-sclerosis-and-schizophrenia-a-case-report
#16
Nahid Noorani, Fateme Hadi, Hamid Reza Ahmadkhaniha
Multiple sclerosis (MS) is the most common debilitating neurological disease that affects adults, whether young adults or middle-aged. Although, most attention is toward the neurological signs of the disease, the neuropsychiatric signs are not uncommon. This case report presents a 29 year old male with a record of obsessive-compulsive disorder (OCD) without psychotic disorder, which coincides with the diagnosis MS, has been stricken to auditory hallucinations and reference delusion. The patient received some antipsychotic drugs such as Haloperidol and Perphenazine irregularly, but any psychotic signs of the patient were never in control...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28163499/long-term-benzodiazepine-treatment-in-patients-with-psychotic-disorders-attending-a-mental-health-service-in-rural-greece
#17
Vaios Peritogiannis, Thiresia Manthopoulou, Venetsanos Mavreas
INTRODUCTION: Long-term benzodiazepine (BZD) treatment in patients with mental disorders is widespread in clinical practice, and this is also the case of patients with schizophrenia, although the evidence is weak and BZD prescription is discouraged by guidelines and medical authorities. Data on BZD prescription are usually derived from national or regional databases whereas information on the use of BZD by patients with schizophrenia and related psychoses in general population-based samples is limited...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28124452/an-uncontrolled-trial-of-multi-component-care-for-first-episode-psychosis-effects-on-social-cognition
#18
Nicholas J K Breitborde, Aubrey M Moe, Cindy Woolverton, Patricia Harrison-Monroe, Emily K Bell
Growing evidence suggests that specialized, multi-component treatment programmes produce improvements in numerous outcomes among individuals with first-episode psychosis. However, these programmes often lack interventions specifically designed to address deficits in social cognition. This raises questions about the effectiveness of such programmes in addressing deficits in social cognition that accompany psychotic disorders. We investigated the effect of participation in a multi-component treatment programme on social cognition among 71 individuals with first-episode psychosis...
January 25, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28117838/early-onset-of-inflammation-during-ontogeny-of-bipolar-disorder-the-nlrp2-inflammasome-gene-distinctly-differentiates-between-patients-and-healthy-controls-in-the-transition-between-ips-cell-and-neural-stem-cell-stages
#19
D Vizlin-Hodzic, Q Zhai, S Illes, K Södersten, K Truvé, T Z Parris, P K Sobhan, S Salmela, S T Kosalai, C Kanduri, J Strandberg, H Seth, T O Bontell, E Hanse, H Ågren, K Funa
Neuro-inflammation and neuronal communication are considered as mis-regulated processes in the aetiology and pathology of bipolar disorder (BD). Which and when specific signal pathways become abnormal during the ontogeny of bipolar disorder patients is unknown. To address this question, we applied induced pluripotent stem cell (iPSC) technology followed by cortical neural differentiation on adipocyte-derived cells from BD type I patients (with psychotic episodes in psychiatric history) and healthy volunteers (controls)...
January 24, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28116203/psychopathology-related-to-energy-drinks-a-psychosis-case-report
#20
Daniel Hernandez-Huerta, Maria Martin-Larregola, Jorge Gomez-Arnau, Javier Correas-Lauffer, Helen Dolengevich-Segal
Energy drinks (ED) are nonalcoholic beverages that have caffeine as their most common active substance. The rapid expansion of ED consumption has created concern in the scientific community as well as in the public opinion. We report a psychotic episode probably triggered by ED abuse in a young adult without previous psychotic disorders. We have reviewed the literature regarding the relationship between caffeine, energy drinks, and psychopathology. Few articles have been published about mental health effects of energy drinks and caffeine abuse...
2017: Case Reports in Psychiatry
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