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https://www.readbyqxmd.com/read/29767567/impact-of-ntrk2-drd2-and-ace-polymorphisms-on-prolactin-levels-in-antipsychotic-treated-patients-with-first-episode-psychosis
#1
Patricia Gassó, Sergi Mas, Miquel Bioque, Bibiana Cabrera, Antonio Lobo, Ana González-Pinto, Covadonga M Díaz-Caneja, Iluminada Corripio, Eduard Vieta, Josefina Castro-Fornieles, Salvador Sarró, Anna Mané, Julio Sanjuan, Adrián Llerena, Amalia Lafuente, Jerónimo Saiz-Ruiz, Miguel Bernardo
BACKGROUND: Hyperprolactinemia is a common side-effect of antipsychotics (APs), which may trigger serious secondary problems and compromise the adherence to treatment which is crucial for prognosis, especially in patients presenting with a first-episode of psychosis (FEP). AIMS: We evaluated, in some cases for the first time, the effect of polymorphisms in multiple candidate genes on serum prolactin (PRL) levels in an AP-treated FEP cohort recruited in the multicenter PEPs study (Phenotype - genotype and environmental interaction; Application of a predictive model in first psychotic episodes)...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29764912/mitochondrial-pitrm1-peptidase-loss-of-function-in-childhood-cerebellar-atrophy
#2
Yeshaya Langer, Adi Aran, Suleyman Gulsuner, Bassam Abu Libdeh, Paul Renbaum, Dario Brunetti, Pedro-Filipe Teixeira, Tom Walsh, Sharon Zeligson, Roberta Ruotolo, Rachel Beeri, Imad Dweikat, Maher Shahrour, Ariella Weinberg-Shukron, Fouad Zahdeh, Enrico Baruffini, Elzbieta Glaser, Mary-Claire King, Ephrat Levy-Lahad, Massimo Zeviani, Reeval Segel
OBJECTIVE: To identify the genetic basis of a childhood-onset syndrome of variable severity characterised by progressive spinocerebellar ataxia, mental retardation, psychotic episodes and cerebellar atrophy. METHODS: Identification of the underlying mutations by whole exome and whole genome sequencing. Consequences were examined in patients' cells and in yeast. RESULTS: Two brothers from a consanguineous Palestinian family presented with progressive spinocerebellar ataxia, mental retardation and psychotic episodes...
May 15, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29754121/early-intervention-services-in-greece-time-to-focus-on-people-at-high-risk
#3
S I Bargiota, V P Bozikas, G Garyfallos, P McGuire
Over the last twenty years, a lot of early intervention services operate worldwide with the aim of offering assistance and promoting the early diagnosis and management, not only of people who experience a first episode of psychosis but also of individuals that are at high risk of developing psychosis. The early intervention services that operate in other countries have been reviewed in correlation with the current status of early intervention services for psychosis in Greece. Early intervention services were first established in Australia, and now hundreds of similar programs exist in Europe, North America and Asia...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29753569/first-presentation-with-psychotic-symptoms-to-the-emergency-department
#4
Yousef Etlouba, Abdullah Laher, Feroza Motara, Muhammed Moolla, Nazeema Ariefdien
BACKGROUND: Mental health conditions account for 52.8 million (4.9-6.3%) emergency department (ED) visits in the United States. Psychotic conditions are responsible for approximately 10% of all mental health presentations. OBJECTIVE: We aimed to determine the underlying etiology and characteristics of patients presenting to the ED with a first episode of psychotic symptoms. METHODS: Medical records of 159 African, Asian, white, and mixed-race patients were prospectively reviewed...
May 10, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29748629/abnormal-reward-prediction-error-signalling-in-antipsychotic-naive-individuals-with-first-episode-psychosis-or-clinical-risk-for-psychosis
#5
Anna O Ermakova, Franziska Knolle, Azucena Justicia, Edward T Bullmore, Peter B Jones, Trevor W Robbins, Paul C Fletcher, Graham K Murray
Ongoing research suggests preliminary, though not entirely consistent, evidence of neural abnormalities in signalling prediction errors in schizophrenia. Supporting theories suggest mechanistic links between the disruption of these processes and the generation of psychotic symptoms. However, it is unknown at what stage in the pathogenesis of psychosis these impairments in prediction-error signalling develop. One major confound in prior studies is the use of medicated patients with strongly varying disease durations...
April 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29743584/is-psychosis-a-multisystem-disorder-a-meta-review-of-central-nervous-system-immune-cardiometabolic-and-endocrine-alterations-in-first-episode-psychosis-and-perspective-on-potential-models
#6
REVIEW
Toby Pillinger, Enrico D'Ambrosio, Robert McCutcheon, Oliver D Howes
People with psychotic disorders show abnormalities in several organ systems in addition to the central nervous system (CNS); and this contributes to excess mortality. However, it is unclear how strong the evidence is for alterations in non-CNS systems at the onset of psychosis, how the alterations in non-CNS systems compare to those in the CNS, or how they relate to symptoms. Here, we consider these questions, and suggest potential models to account for findings. We conducted a systematic meta-review to summarize effect sizes for both CNS (focusing on brain structural, neurophysiological, and neurochemical parameters) and non-CNS dysfunction (focusing on immune, cardiometabolic, and hypothalamic-pituitary-adrenal (HPA) systems) in first-episode psychosis (FEP)...
May 9, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29739135/unipolar-mania-a-particular-aspect-of-bipolar-disorder-in-tunisia
#7
Badii Amamou, Wafa Chebbi, Myriam Allegue, Ahmed Mhalla, Ferid Zaafrane, Lotfi Gaha
Objective: Unipolar mania is a clinical reality in our daily practice. Many authors suggested that bipolar patients can have only manic episodes without depressions. These findings lead us to explore more this particularity. Methods: We conduct a retrospective, descriptive and comparative study including 173 patients, followed for bipolar disorder type I, according to the Diagnostic and Statistical Manual of Mental Disorders fifth edition criteria, during the period between January 2008 and December 2015...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29736129/analysis-of-misdiagnosis-of-bipolar-disorder-in-an-outpatient-setting
#8
Hui Shen, Li Zhang, Chuchen Xu, Jinling Zhu, Meijuan Chen, Yiru Fang
Background: Bipolar disorder is a mental illness with a high misdiagnosis rate and commonly misdiagnosed as other mental disorders including depression, schizophrenia, anxiety disorders, obsessive-compulsive disorders, and personality disorders, resulting in the mistreatment of clinical symptoms and increasing of recurrent episodes. Aims: To understand the reasons for misdiagnosis of bipolar disorder in an outpatient setting in order to help clinicians more clearly identify the disease and avoid diagnostic errors...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29726413/a-new-machine-learning-framework-for-understanding-the-link-between-cannabis-use-and-first-episode-psychosis
#9
Wajdi Alghamdi, Daniel Stamate, Daniel Stahl, Alexander Zamyatin, Robin Murray, Marta Di Forti
Lately, several studies started to investigate the existence of links between cannabis use and psychotic disorders. This work proposes a refined Machine Learning framework for understanding the links between cannabis use and 1st episode psychosis. The novel framework concerns extracting predictive patterns from clinical data using optimised and post-processed models based on Gaussian Processes, Support Vector Machines, and Neural Networks algorithms. The cannabis use attributes' predictive power is investigated, and we demonstrate statistically and with ROC analysis that their presence in the dataset enhances the prediction performance of the models with respect to models built on data without these specific attributes...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29696781/duration-of-untreated-psychosis-and-clinical-outcomes-of-first-episode-psychosis-an-observational-and-an-instrumental-variables-analysis
#10
Sarah A Sullivan, Robert Carroll, Tim J Peters, Tim Amos, Peter B Jones, Max Marshall, Max Birchwood, David Fowler, Sonia Johnson, Helen L Fisher, Barnaby Major, Nikola Rahaman, John Joyce, Nick Chamberlain-Kent, Jo Lawrence, Paul Moran, Kate Tilling
AIM: Duration of untreated psychosis (DUP) is considered as a key prognostic variable in psychosis. Yet, it is unclear whether a longer DUP causes worse outcomes or whether reported associations have alternative explanations. METHODS: Data from 2 cohorts of patients with first episode psychosis were used (n = 2134). Measures of DUP were assessed at baseline and outcomes at 12 months. Regression models were used to investigate the associations between DUP and outcomes...
April 26, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29694935/does-dissociation-mediate-the-relationship-between-childhood-trauma-and-hallucinations-delusions-in-first-episode-psychosis
#11
Pamela Sun, Mario Alvarez-Jimenez, Katrina Simpson, Katherine Lawrence, Natalie Peach, Sarah Bendall
BACKGROUND: Childhood trauma has been linked to the presence of delusions and hallucinations in psychosis, although the mechanisms underlying this relationship require elucidation. Dissociation, characterized by disruptions to the integrative functioning of several core mental domains, has emerged as a potential mechanism. There is a paucity of research using a clinician-rated measure of dissociation to test the indirect effect of dissociation on the relationship between childhood trauma and psychotic symptoms...
April 11, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29684464/tracking-single-membrane-targets-of-human-autoantibodies-using-single-nanoparticle-imaging
#12
Julie Jézéquel, Julien P Dupuis, François Maingret, Laurent Groc
BACKGROUND: Over the past decade, an increasing number of neurological and neuropsychiatric diseases have been associated with the expression of autoantibodies directed against neuronal targets, including neurotransmitter receptors. Although cell-based assays are routinely used in clinics to detect the presence of immunoglobulins, such tests often provide heterogeneous outcomes due to their limited sensitivity, especially at low titers. Thus, there is an urging need for new methods allowing the detection of autoantibodies in seropositive patients that cannot always be clinically distinguished from seronegative ones...
April 20, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29679071/determinants-of-treatment-response-in-first-episode-psychosis-an-18-f-dopa-pet-study
#13
Sameer Jauhar, Mattia Veronese, Matthew M Nour, Maria Rogdaki, Pamela Hathway, Federico E Turkheimer, James Stone, Alice Egerton, Philip McGuire, Shitij Kapur, Oliver D Howes
Psychotic illnesses show variable responses to treatment. Determining the neurobiology underlying this is important for precision medicine and the development of better treatments. It has been proposed that dopaminergic differences underlie variation in response, with striatal dopamine synthesis capacity (DSC) elevated in responders and unaltered in non-responders. We therefore aimed to test this in a prospective cohort, with a nested case-control comparison. 40 volunteers (26 patients with first-episode psychosis and 14 controls) received an 18 F-DOPA Positron Emission Tomography scan to measure DSC (Kicer ) prior to antipsychotic treatment...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29677618/altered-serum-levels-of-vascular-endothelial-growth-factor-in-first-episode-drug-na%C3%A3-ve-and-chronic-medicated-schizophrenia
#14
Fei Ye, Qiongqiong Zhan, Wenhuan Xiao, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
There is much evidence of a relationship between alterations in the brain's regional cellular energy metabolism and blood flow in schizophrenic. Vascular endothelial growth factor (VEGF) plays a role in the pathogenesis of neuropsychiatric illnesses. So, we compared serum VEGF levels in drug-naïve first-episode psychotic (FEP) and chronically medicated schizophrenic to examine if a correlation existed between VEGF and psychopathological symptoms. The serum VEGF levels were assessed in 46 FEP patients, 47 chronic medicated patients and 50 healthy controls...
April 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29661524/expressed-emotion-as-a-predictor-of-the-first-psychotic-episode-results-of-the-european-prediction-of-psychosis-study
#15
Theresa Haidl, Marlene Rosen, Frauke Schultze-Lutter, Dorien Nieman, Susanne Eggers, Markus Heinimaa, Georg Juckel, Andreas Heinz, Anthony Morrison, Don Linszen, Raimo Salokangas, Joachim Klosterkötter, Max Birchwood, Paul Patterson, Stephan Ruhrmann
OBJECTIVE: To investigate the impact of expressed emotion (EE) on the risk of developing the first psychotic episode (FEP). METHOD: The European Prediction of Psychosis Study (EPOS) investigated 245 patients who were at clinical high risk (CHR) of psychosis. The predictive value of EE alone and as a part of the multivariate EPOS model was evaluated. RESULTS: "Perceived irritability", a domain of the Level of Expressed Emotion Scale (LEE), was found to be predictive for the First Psychotic Episode (FEP), even as an individual variable...
April 13, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29661027/social-determinants-of-health-and-preclinical-glycemic-control-in-newly-diagnosed-first-episode-psychosis-patients
#16
Franz Veru-Lesmes, Aldanie Rho, Suzanne King, Ridha Joober, Marita Pruessner, Ashok Malla, Srividya N Iyer
BACKGROUND: The abnormally high incidence of disorders of glucose metabolism (DGM) in psychotic-spectrum disorders (PSD) has often been attributed to the side effects of antipsychotics and unhealthy lifestyles. The influence of social determinants of health has been largely ignored, despite ample evidence linking social adversity with both PSD and DGM. The aim of this study is to examine the influence of well-established social determinants of health on preclinical levels of glycated hemoglobin (HbA1c) in a sample of first-episode psychosis (FEP) patients...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29656029/gamma-band-oscillations-in-the-early-phase-of-psychosis-a-systematic-review
#17
REVIEW
Thomas J Reilly, Judith F Nottage, Erich Studerus, Grazia Rutigliano, Andrea I De Micheli, Paolo Fusar-Poli, Philip McGuire
Abnormal gamma oscillations, measured by electroencephalography (EEG), have been associated with chronic psychotic disorders, but their prevalence in the early phase of psychosis is less clear. We sought to address this issues by systematically reviewing the relevant literature. We searched for EEG studies of gamma band oscillations in subjects at high risk for psychosis and in patients with first episode psychosis. The following measures of gamma oscillations were extracted: resting power, evoked power, induced power, connectivity and peak frequency...
April 12, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29614389/duration-of-active-psychosis-and-functional-outcomes-in-first-episode-non-affective-psychosis
#18
José María Pelayo-Terán, Virginia Gajardo-Galán, Marcos Gómez-Revuelta, Victor Ortiz-García de la Foz, Rosa Ayesa-Arriola, Rafael Tabarés-Seisdedos, Benedicto Crespo-Facorro
BACKGROUND: The duration of untreated psychosis (DUP) has been associated with negative outcomes in psychosis; however, few studies have focused on the duration of active psychotic symptoms after commencing treatment (DAT). In this study, we aimed to evaluate the effect of DUP and DAT on functional long-term outcomes (3 years) in patients with early psychosis. METHODS: We evaluated the Scale for the Assessment of Positive Symptoms (SAPS) at frequent intervals for 3 years after presentation to determine the DAT for 307 individuals with first-episode psychosis together with DUP and clinical variables...
March 31, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29603625/psychopathology-cognition-and-outcome-in-dutch-and-immigrant-first-episode-psychosis-patients
#19
Luyken H Stouten, Wim Veling, Winfried Laan, Mark Van der Gaag
AIM: The primary aim was to examine differences in baseline symptom expression, neurocognition, social cognition and psychosocial functioning between Dutch, first-generation immigrants and second-generation immigrants with a first-episode psychosis (FEP). The secondary aim was to examine functional and symptomatic change and between-group differences at 12-months follow-up. Associations between migration, baseline characteristics and outcome were explored. METHODS: Forty-six Dutch, 56 second-generation- and 60 first-generation immigrant patients completed baseline measures for 6 symptom dimensions (positive symptoms, negative symptoms, neurocognitive functioning, social cognitive functioning, excitement and emotional distress) and 5 domains of psychosocial functioning (general functioning, work and study, relationships, self-care and disturbing behaviour)...
March 30, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29593580/self-reported-visual-perceptual-abnormalities-are-strongly-associated-with-core-clinical-features-in-psychotic-disorders
#20
Brian P Keane, Lisa N Cruz, Danielle Paterno, Steven M Silverstein
Background: Past studies using the Bonn Scale for the Assessment of Basic Symptoms (hereafter, Bonn Scale) have shown that self-reported perceptual/cognitive disturbances reveal which persons have or will soon develop schizophrenia. Here, we focused specifically on the clinical value of self-reported visual perceptual abnormalities (VPAs) since they are underexplored and have been associated with suicidal ideation, negative symptoms, and objective visual dysfunction. Method: Using the 17 Bonn Scale vision items, we cross-sectionally investigated lifetime occurrence of VPAs in 21 first-episode psychosis and 22 chronic schizophrenia/schizoaffective disorder (SZ/SA) patients...
2018: Frontiers in Psychiatry
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