Kota Kojima, Hiroyuki Miyoshi, Narihito Nagoshi, Jun Kohyama, Go Itakura, Soya Kawabata, Masahiro Ozaki, Tsuyoshi Iida, Keiko Sugai, Shuhei Ito, Ryuji Fukuzawa, Kaori Yasutake, Francois Renault-Mihara, Shinsuke Shibata, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano
Tumorigenesis is an important problem that needs to be addressed in the field of human stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI). When certain "tumorigenic" cell lines are transplanted into the spinal cord of SCI mice model, there is initial improvement of motor function, followed by abrupt deterioration secondary to the effect of tumor growth. A significant proportion of the transplanted cells remains undifferentiated after transplantation and is thought to increase the risk of tumorigenesis...
November 28, 2018: Stem Cells Translational Medicine