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Spinal cord injury suicide

Araceli Flores, Marsha M Linehan, S Rob Todd, Hunter G Hoffman
Introduction: Paralysis from a spinal cord injury (SCI) increases risk of psychological problems including suicide attempts, substance use disorder, negative emotions (e.g., anger), depression, anxiety, ASD/PTSD. Dialectical Behavioral Therapy® (DBT®) has been shown to be effective for treating similar psychological symptoms in non-SCI patient populations. The current study explored for the first time, the feasibility and clinical potential of using Immersive Virtual Reality (VR) enhanced DBT® Mindfulness skills training to help reduce psychological symptoms (negative emotions and anxiety, ASD/PTSD) of two patients with SCI...
2018: Frontiers in Psychology
Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D'Adamo, Luca Muzio, Gianvito Martino
BACKGROUND: Spinal cord injury (SCI) is a devastating condition mainly deriving from a traumatic damage of the spinal cord (SC). Immune cells and endogenous SC-neural stem cells (SC-NSCs) play a critical role in wound healing processes, although both are ineffective to completely restore tissue functioning. The role of SC-NSCs in SCI and, in particular, whether such cells can interplay with the immune response are poorly investigated issues, although mechanisms governing such interactions might open new avenues to develop novel therapeutic approaches...
February 23, 2018: Journal of Neuroinflammation
Mahammad Abbas Tafida, Yukiko Wagatsuma, Enbo Ma, Taro Mizutani, Toshikazu Abe
BACKGROUND: Spine injury epidemiology in Japan has not been studied since the 1990s when its incidence was 39.4-40.2 per million and the major cause of injury was motor vehicle crashes. We elucidate the current epidemiological state of spinal injury and spinal injury patients in Japan for the clinicians and public health prevention programs. METHODS: Spine injury patients were retrospectively selected from the Japan Trauma Data Bank (JTDB) from 2004 to 2013 for all ages and all spinal injuries...
November 14, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Matthew Herrmann, Prissilla Xu, Antonio Liu
Background: Common side effects of selective serotonin reuptake inhibitors (SSRIs) include tachycardia, drowsiness, tremor, nausea, and vomiting. Although SSRIs have less toxic side effects compared to more traditional antidepressants, serious and life threatening cases of SSRI overdose have been reported. We describe a 24-year-old multimorbid female who presented to the emergency department with rapid onset ascending sensorimotor paralysis, complicated by respiratory and cardiac arrest, found to have fatal levels of fluoxetine by toxicological analysis, not taken in a suicidal act...
2017: Case Reports in Neurological Medicine
G Savic, M J DeVivo, H L Frankel, M A Jamous, B M Soni, S Charlifue
STUDY DESIGN: Retrospective and prospective observational. OBJECTIVE: The main objective of this study was to analyse suicide attempt as a cause of traumatic spinal cord injury (tSCI) and suicide as a cause of death after tSCI. SETTING: This study was conducted at two British spinal centres, Stoke Mandeville and Southport. METHODS: Long-term survival of patients who were newly admitted between 1991 and 2010, had survived the first post-injury year and had neurological deficit on discharge...
January 2018: Spinal Cord
Chantal Roddy, Nikki Rickard, Jeanette Tamplin, Felicity Anne Baker
CONTEXT/OBJECTIVE: Spinal Cord Injury (SCI) patients face unique identity challenges associated with physical limitations, higher comorbid depression, increased suicidality and reduced subjective well-being. Post-injury identity is often unaddressed in subacute rehabilitation environments where critical physical and functional rehabilitation goals are prioritized. Therapeutic songwriting has demonstrated prior efficacy in promoting healthy adjustment and as a means of expression for post-injury narratives...
August 24, 2017: Journal of Spinal Cord Medicine
G Savic, M J DeVivo, H L Frankel, M A Jamous, B M Soni, S Charlifue
DESIGN: Retrospective and prospective observational. OBJECTIVE: Analyse causes of death after traumatic spinal cord injury (tSCI) in persons surviving the first year post injury, and establish any trend over time. SETTING: Two spinal centres in Great Britain. METHODS: The sample consisted of 5483 patients with tSCI admitted to Stoke Mandeville and Southport spinal centres who were injured between 1943 and 2010, survived first year post injury, had residual neurological deficit on discharge and were British residents...
October 2017: Spinal Cord
Xiulu Ruan, Jin Jun Luo
No abstract text is available yet for this article.
May 2017: Journal of Spinal Cord Medicine
Julia M P Poritz, Joseph Mignogna, Aimee J Christie, Sally A Holmes, Herb Ames
CONTEXT: Although depression is not inevitable following spinal cord injury/dysfunction (SCI/D), it can have a negative impact on rehabilitation. Evidence-based assessment of depression utilizing self-report instruments, such as the Patient Health Questionnaire-9 (PHQ-9), is considered good clinical practice. Although the PHQ-9 has been studied in individuals with SCI/D, little is known about the clinical utility of the Patient Health Questionnaire-2 (PHQ-2). Traditional cutoff scores for the PHQ-2 were examined to explore their operating characteristics as related to PHQ-9 results...
March 2018: Journal of Spinal Cord Medicine
Jose M Palacios, Angel Pazos, Daniel Hoyer
This paper is a personal account on the discovery and characterization of the 5-HT2C receptor (first known as the 5-HT1C receptor) over 30 years ago and how it translated into a number of unsuspected features for a G protein-coupled receptor (GPCR) and a diversity of clinical applications. The 5-HT2C receptor is one of the most intriguing members of the GPCR superfamily. Initially referred to as 5-HT1C R, the 5-HT2C R was discovered while studying the pharmacological features and the distribution of [3 H]mesulergine-labelled sites, primarily in the brain using radioligand binding and slice autoradiography...
May 2017: Psychopharmacology
P Kennedy, L Garmon-Jones
STUDY DESIGN: This is a systematic literature review. OBJECTIVES: The objectives of this study were to investigate, first, the proportion of spinal cord injury (SCI) caused by suicidal behaviour; second, the proportion of deaths in the SCI population caused by suicide; and third, the risk factors associated with suicidal behaviour. SETTING: This study was conducted in the UK. METHODS: AMED, EMBASE, HMIC, BNI, Medline, PsycInfo, CINAHL and HEALTH BUSINESS ELITE were searched between January and February 2016, identifying a total of 404 articles published between 1990 and 2016...
January 2017: Spinal Cord
R Osterthun, F W A van Asbeck, J H B Nijendijk, M W M Post
STUDY DESIGN: Explorative retrospective files study. OBJECTIVES: To document end-of-life decisions (ELDs) in in-hospital deaths after new traumatic spinal cord injury (TSCI). SETTING: The Netherlands. METHODS: Discharge letters concerning patients with TSCI discharged from Dutch acute hospitals in 2010 were analysed. Data were extracted on survival, personal and lesion characteristics, comorbidities, other injuries, preexisting spinal stenosis, stabilising surgery, length of hospital stay and the presence and types of ELDs...
November 2016: Spinal Cord
Zahra Khazaeipour, Seyedeh-Mohadeseh Taheri-Otaghsara, Maryam Naghdi
BACKGROUND: Depression is a common psychological problem that decreases life satisfaction and quality of life in people with spinal cord injury (SCI). OBJECTIVE: The aim of this study was to investigate the prevalence of depression after SCI and its association with pathophysiological, demographic, and socioeconomic factors, including sex, age, level of injury, financial status, and suicidal thoughts. METHODS: This was a cross-sectional study of 134 adults (≥ 18 years old) with SCI who were referred to the Brain and Spinal Cord Injury Research Center (BASIR) clinic, Tehran University of Medical Sciences, for outpatient rehabilitation...
2015: Topics in Spinal Cord Injury Rehabilitation
Brett Smith, Nick Caddick
In the UK, 20% of people with spinal cord injury (SCI) are discharged from rehabilitation into an elderly care home. Despite this, and knowledge that the home is central to health and wellbeing, little research has examined the impact of being in care homes on the health and wellbeing of people with SCI. The purpose of this study was to address this gap. Twenty adults who lived in care homes or had done so recently for over two years were interviewed in-depth. Qualitative data were analyzed using inductive thematic analysis...
April 15, 2015: International Journal of Environmental Research and Public Health
Cheryl B McCullumsmith, Claire Z Kalpakjian, J Scott Richards, Martin Forchheimer, Allen W Heinemann, Elizabeth J Richardson, Catherine S Wilson, Jason Barber, Nancy Temkin, Charles H Bombardier, Jesse R Fann
OBJECTIVE: To determine unique associations of suicidal ideation (SI) and lifetime suicide attempts (SAs) in individuals with spinal cord injury (SCI). DESIGN: Cross-sectional analysis. SETTING: Outpatient. PARTICIPANTS: Individuals with SCI (N=2533) who were 18 years or older with a history of traumatic SCI. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Any SI in the past 2 weeks (9-item Patient Health Questionnaire) and any lifetime SA...
May 2015: Archives of Physical Medicine and Rehabilitation
Shayne N Hassler, Kathia M Johnson, Claire E Hulsebosch
Chronic neuropathic pain is a common consequence of spinal cord injury (SCI), develops over time and negatively impacts quality of life, often leading to substance abuse and suicide. Recent evidence has demonstrated that reactive oxygen species (ROS) play a role in contributing to neuropathic pain in SCI animal models. This investigation examines four compounds that reduce ROS and the downstream lipid peroxidation products, apocynin, 4-oxo-tempo, U-83836E, and tirilazad, and tests if these compounds can reduce nocioceptive behaviors in chronic SCI animals...
November 2014: Journal of Neurochemistry
Zahra Khazaeipour, Abbas Norouzi-Javidan, Mahboobeh Kaveh, Fatemeh Khanzadeh Mehrabani, Elham Kazazi, Seyed-Hasan Emami-Razavi
Objective/background In patients with spinal cord injury (SCI), SCI causes psychosocial complications that vary based on culture, conditions, and the amenities of each community. Health planners and social services should have full knowledge of these issues in order to plan schedules that address them. In this study, we aimed to understand the psychosocial problems of persons with SCI in Iran and to explore the requirements for minimizing these difficulties. Design This was a descriptive cross-sectional study...
May 2014: Journal of Spinal Cord Medicine
Sara J Klaas, Erin H Kelly, Caroline J Anderson, Lawrence C Vogel
BACKGROUND: Little is known about depression and anxiety in adolescents with spinal cord injury (SCI). OBJECTIVE: To examine how depression, anxiety, suicidal ideation, and usage of treatment differ by age and sex among adolescents with SCI. METHOD: Youth 12 to 18 years old who had acquired SCI at least 1 year prior were recruited from 3 specialty hospitals. They completed the Children's Depression Inventory (ages 12-17 years) or Beck Depression Inventory-II (18 years), and Revised Children's Manifest Anxiety Scale (12-18 years)...
2014: Topics in Spinal Cord Injury Rehabilitation
Yue Cao, James F Massaro, James S Krause, Yuying Chen, Michael J Devivo
OBJECTIVES: To compare 12-year suicide-specific mortalities of 3 different injury cohorts, identify the risk factors for suicide mortality after spinal cord injury (SCI), and investigate whether suicide mortality is higher among those with SCI than in the general population. DESIGN: Retrospective cohort study. SETTING: United States hospitals (n=28) designated as SCI Model Systems. PARTICIPANTS: Participants (N=31,339) injured between January 1, 1973, and December 31, 1999...
February 2014: Archives of Physical Medicine and Rehabilitation
Halina Piatkowska
The study presents the image of psychopathological complications in subjects after traumatic spinal cord injuries.Part I Methods: clinical investigation/orthopedic, neurological, psychiatric/laboratory tests, X-Ray exam. CFS exam. EEG exam. EMG exam. Psychological diagnosis.Part II A. Acute period: posttraumatic state, disorders of consciousness, disorders of perception, psychotic reactionsB. Subacute period: state of physical dependence, problems of self identification, alterations of body image, disorders of behavior and of emotional functions, hipodepressive and epressive states, suicidal thoughts...
December 1994: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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