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Iron related to anemia in female adults

Caglar Doguer, Jung-Heun Ha, Sukru Gulec, Chris D Vulpe, Gregory J Anderson, James F Collins
Regulation of intestinal iron absorption is crucial to maintain body iron levels because humans have no regulated iron-excretory system. Elucidating molecular events that mediate intestinal iron transport is thus important for the development of therapeutic approaches to modify iron absorption in pathological states. The process of iron uptake into duodenal enterocytes is relatively well understood, but less is known about the functional coupling between the iron exporter ferroportin 1 and the basolateral membrane iron oxidase hephaestin (Heph)...
July 25, 2017: Blood Advances
Lijuan Wang, Jian Huang, Hong Li, Jing Sun, Jianhua Piao, Xiaoguang Yang, Guansheng Ma, Junsheng Huo
BACKGROUND AND OBJECTIVES: To assess the distribution of serum ferritin, serum soluble transferrin receptor and body iron among girls and women by age and anaemia. METHODS AND STUDY DESIGN: Serum ferritin, serum soluble transferrin receptor and high sensitive C-reactive protein of 1625 and 1372 women in general and anaemic were measured in the National Health and Nutrition Survey commenced in 2010. RESULTS: The distributions of serum ferritin, serum soluble transferrin receptor and body iron for 6-11-y, 12-17-y, 18-44-y, 45-59-y and >=60-y subgroups were significantly different...
2016: Asia Pacific Journal of Clinical Nutrition
O N Glagoleva, D V Turchaninov, L A Boyarskaya, I V Bogdashin
The pilot controlled study proved the effectiveness of enriched fermented milk product "Prolacta" as means of the primary prevention of nutrition-associated anemia, firstly, at the stage of latent iron deficiency. The study included 166 adult residents of the city of Omsk. Among examined patiens there were 48 (30%) men and 118 (70%) women aged from 18 to 59 years (mean age: 29.2 ± 0.84 years). Experimental group (79 persons) over two months took 1 glass (200 ml) of bioproduct "Prolacta" daily. The control group (87 people) no received this product neither used supplements or other vitamins and minerals...
2015: Gigiena i Sanitariia
O N Glagoleva, D V Turchaninov, E A Vilms
There was performed an experimental study of the use of educational programs as tools of the improvement of the structure of nutrition and primary prevention of anemias associated with nutrition. Educational programs were differentiated for each of the target audience (pupils of 5-7 classes, 1-4 year students of the medical school, the adult unorganized population; n = 645). Their efficacy was evaluated with the use of issues included in the educational program and analysis of the actual nutrition (only in groups of students and adults)...
2015: Gigiena i Sanitariia
Erhan Yumusak, Aydin Ciftci, Selim Yalcin, Cemile Dayangan Sayan, Nevin Hande Dikel, Kemal Ornek
BACKGROUND: The aim of this study was to investigate the potential significance of the central macular thickness (foveal thickness-FT) and choroidal thickness (CT) in the eyes of patients with iron-deficiency anemia, the most common form of the anemia, via enhanced-depth imaging optical coherence tomography (EDI-OCT). We also investigated whether such changes might serve as an early indicator of underlying hematological disease. METHODS: This prospective clinical study compared 96 female patients with iron-deficiency anemia and 60 healthy female control subjects...
2015: BMC Ophthalmology
Samuel P Scott, Laura E Murray-Kolb
BACKGROUND: Iron deficiency (ID) is prevalent, particularly among women of reproductive age (WRA). How mild ID without anemia relates to cognition is poorly understood. Executive functioning (EF) has emerged as potentially being affected by mild ID in WRA. OBJECTIVE: We sought to examine how iron markers relate to performance on EF tasks in nonanemic WRA. METHODS: Participants included 127 females aged 18-35 y. Hematological indicators included hemoglobin, RBC distribution width, transferrin saturation (TSAT), ferritin, transferrin receptor (TfR), and total body iron (TBI)...
January 2016: Journal of Nutrition
Shuang Yang, Xiao-Ying Chen, Xiao-Ping Xu
BACKGROUND: The relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2), cholesteryl ester transfer protein (CETP), and risk of atherosclerosis in IDA women has not been fully clarified. The objective of this study was to investigate lipid-related atherogenic risk factors in women with IDA. METHODS: Eighty women with IDA and 80 age-matched healthy women as the control group were enrolled in the study. Serum lipid profile, Lp-PLA2, and CETP were determined...
2015: Clinical Laboratory
Ana C Cepeda-Lopez, Alida Melse-Boonstra, Michael B Zimmermann, Isabelle Herter-Aeberli
BACKGROUND: Iron deficiency is common in overweight and obese individuals. This deficiency may be due to adiposity-related inflammation that increases serum hepcidin and decreases dietary iron absorption. Because hepcidin reduces iron efflux from the basolateral enterocyte, it is uncertain whether luminal enhancers of dietary iron absorption such as ascorbic acid can be effective in overweight and obese individuals. OBJECTIVE: In this study, we compared iron absorption from a meal with ascorbic acid (+AA) and a meal without ascorbic acid (-AA) in women in a normal-weight group (NW) with those in overweight and obese groups combined (OW/OB)...
December 2015: American Journal of Clinical Nutrition
Michelle Olson, Camden Hebson, Alexandra Ehrlich, Tamara New, Ritu Sachdeva
Diastolic dysfunction has been shown to occur earlier than systolic dysfunction in iron overload states in adult patients with sickle cell disease (SCD). Tissue Doppler imaging (TDI)-derived E/E' has emerged as a noninvasive marker of diastolic function. We sought to determine diastolic function in children with SCD and study its relation with iron overload. A retrospective review of medical records of 225 pediatric patients with SCD who received an echocardiogram between January 2008 and December 2012 was performed...
January 2016: Journal of Pediatric Hematology/oncology
Klaus Schmitz-Abe, Szymon J Ciesielski, Paul J Schmidt, Dean R Campagna, Fedik Rahimov, Brenda A Schilke, Marloes Cuijpers, Klaus Rieneck, Birgitte Lausen, Michael L Linenberger, Anoop K Sendamarai, Chaoshe Guo, Inga Hofmann, Peter E Newburger, Dana Matthews, Akiko Shimamura, Pieter J L M Snijders, Meghan C Towne, Charlotte M Niemeyer, Henry G Watson, Morten H Dziegiel, Matthew M Heeney, Alison May, Sylvia S Bottomley, Dorine W Swinkels, Kyriacos Markianos, Elizabeth A Craig, Mark D Fleming
The congenital sideroblastic anemias (CSAs) are relatively uncommon diseases characterized by defects in mitochondrial heme synthesis, iron-sulfur (Fe-S) cluster biogenesis, or protein synthesis. Here we demonstrate that mutations in HSPA9, a mitochondrial HSP70 homolog located in the chromosome 5q deletion syndrome 5q33 critical deletion interval and involved in mitochondrial Fe-S biogenesis, result in CSA inherited as an autosomal recessive trait. In a fraction of patients with just 1 severe loss-of-function allele, expression of the clinical phenotype is associated with a common coding single nucleotide polymorphism in trans that correlates with reduced messenger RNA expression and results in a pseudodominant pattern of inheritance...
December 17, 2015: Blood
Analee J Etheredge, Zul Premji, Nilupa S Gunaratna, Ajibola Ibraheem Abioye, Said Aboud, Christopher Duggan, Robert Mongi, Laura Meloney, Donna Spiegelman, Drucilla Roberts, Davidson H Hamer, Wafaie W Fawzi
IMPORTANCE: Anemia is common in pregnancy and increases the risk of adverse outcomes. Iron deficiency is a leading cause of anemia in sub-Saharan Africa, and iron supplementation is the standard of care during pregnancy; however, recent trials among children have raised concerns regarding the safety of iron supplementation in malaria-endemic regions. There is limited evidence on the safety of iron supplementation during pregnancy in these areas. OBJECTIVE: To evaluate the safety and efficacy of iron supplementation during pregnancy in a malaria-endemic region...
October 2015: JAMA Pediatrics
J J Feld, G J Kato, C Koh, T Shields, M Hildesheim, D E Kleiner, J G Taylor, N G Sandler, D Douek, V Haynes-Williams, J S Nichols, J H Hoofnagle, T Jake Liang, M T Gladwin, T Heller
BACKGROUND: Increased life expectancy in sickle cell disease (SCD) has resulted in greater recognition of the consequences of repeated intravascular vaso-occlusion and chronic haemolysis to multiple organ systems. AIM: To report the long-term consequences of liver dysfunction in SCD. METHODS: A cohort of SCD patients was prospectively evaluated at the National Institutes of Health (NIH) Clinical Center. The association of mortality with liver enzymes, parameters of liver synthetic function and iron overload was evaluated using Cox regression...
October 2015: Alimentary Pharmacology & Therapeutics
Manpreet K Sandhu, Alice Cohen
Availability of hydroxyurea (HU) coupled with early therapeutic interventions has increased the life expectancy of patients with sickle cell disease. Hence, the sickle cell community needs to be aware of common diseases of aging that survivors are predisposed to. We chose to investigate the sickle cell disease-related complications as well as non sickle cell disease-related medical problems of aging in 45 sickle cell patients over the age of 40 years. The most frequent chronic complications of sickle cell disease were elevated tricuspid regurgitant jet velocity on echocardiogram, chronic renal disease, iron overload and leg ulcers...
2015: Hemoglobin
Tian Tian, Shuang Yu, Lu Liu, Fuzhong Xue, Cunzhong Yuan, Min Wang, Chunyan Ji, Daoxin Ma
BACKGROUND: T helper (Th) cells immune regulation is important for the pathogenesis of acute myeloid leukemia (AML). Recurrent Th abnormalities in AML peripheral blood were reported, while the comprehensive status of various Th subsets is rarely investigated in bone marrow (BM) microenvironment which is the origin of AML leukemic blast cells. METHODS: BM was extracted from 48 newly-diagnosed (ND), 34 complete-remission (CR), 19 relapsed-refractory AML patients and 15 controls...
2015: PloS One
James B Wetmore, Yi Peng, Keri L Monda, Allyson M Kats, Deborah H Kim, Brian D Bradbury, Allan J Collins, David T Gilbertson
BACKGROUND/AIMS: Recent changes in clinical practice guidelines and reimbursement policies may have affected the use of anemia-related medications and red blood cell (RBC) transfusions in peritoneal dialysis (PD) and hemodialysis (HD) patients. We sought to compare patterns of erythropoiesis-stimulating agents (ESA) and intravenous (IV) iron use, achieved hemoglobin levels, and RBC transfusion use in PD and HD patients. METHODS: In quarterly cohorts of prevalent dialysis patients receiving persistent therapy (>3 months), 2007-2011, with Medicare Parts A and B coverage, we assessed ESA and IV iron use and dose, RBC transfusions, and hemoglobin levels...
2015: American Journal of Nephrology
Aysun Karabulut, Ömer Tolga Güler, Hatice Tuba Karahan, Sevgi Özkan, Hasan Koyuncu, Ibrahim Demirciler
BACKGROUND/AIM: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus. We aimed to investigate hemoglobin, ferritin, folate, and vitamin B12 levels in preconceptional women in an area where a plant-based diet referred to as Mediterranean cuisine is commonly used. MATERIALS AND METHODS: The study population included 466 women between the ages of 18 and 45 years admitted for thalassemia screening...
2015: Turkish Journal of Medical Sciences
Charlotte M Page, Archana Patel, Patricia L Hibberd
BACKGROUND: Anemia affects upwards of 50% of pregnant women in developing countries and is associated with adverse outcomes for mother and child. We hypothesized that exposure to smoke from biomass fuel--which is widely used for household energy needs in resource-limited settings--could exacerbate anemia in pregnancy, possibly as a result of systemic inflammation. OBJECTIVE: To evaluate whether exposure to smoke from biomass fuel (wood, straw, crop residues, or dung) as opposed to clean fuel (electricity, liquefied petroleum gas, natural gas, or biogas) is an independent risk factor for anemia in pregnancy, classified by severity...
2015: PloS One
N I Ugwu, O A Awodu, G N Bazuaye, A E Okoye
BACKGROUND: Sickle cell anemia (SCA) is an inherited hemoglobin disorder characterized by chronic anemia and occasional crises. Clinical features are variable. While some individuals are relatively stable and rarely require blood transfusion, others often require blood transfusion. Multiple blood transfusion is associated with complications including alloimmunization, infections, and iron overload. AIMS AND OBJECTIVES: The study aimed at determining the prevalence of red cell alloimmunization among multi-transfused patients with SCA...
July 2015: Nigerian Journal of Clinical Practice
Ioannis Bakoyiannis, Eleana Gkioka, Afrodite Daskalopoulou, Laskarina-Maria Korou, Despina Perrea, Vasilios Pergialiotis
Iron deficiency (ID) is a major public health problem worldwide among children aged 0-12 months. Several factors seem to contribute to the iron-deficient state in infancy, including insufficient antenatal and neonatal iron supplementation, exclusive breastfeeding, and early umbilical cord clamping after birth. The most concerning complications of ID, except for anemia, are related to altered long-term neurodevelopment. Clinical studies have shown a negative impact of ID anemia on fetal and neonatal behavior including impairments of motor maturity, autonomic response, memory/learning, and mood...
2015: Reviews in the Neurosciences
Geertje Jansma, Fellery de Lange, W Peter Kingma, Namkje A R Vellinga, Matty Koopmans, Michael A Kuiper, E Christiaan Boerma
BACKGROUND: Anemia is a common feature during sepsis that occurs due to iatrogenic blood loss, depression of serum iron levels and erythropoietin production, and a decreased lifespan of erythrocytes. However, these mechanisms are unlikely to play a role in anemia at the start of sepsis. Moreover, sequestration of fluids, renal failure and increase of intravascular space may additionally influence the change in hemoglobin concentration during intravenous fluid administration in the acute phase of sepsis...
2015: BMC Anesthesiology
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