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Francisco Manchado de Sola, Manuel Vilches, Yolanda Prezado, Antonio M Lallena
PURPOSE: To assess the effects of brain movements induced by heartbeat on dose distributions in synchrotron micro- and mini-beam radiaton therapy and to develop a model to help guide decisions and planning for future clinical trials. METHODS: The Monte Carlo code PENELOPE was used to simulate the irradiation of a human head phantom with a variety of micro- and mini-beam arrays, with beams narrower than 100 μm and above 500 μm, respectively, and with radiation fields of 1cm × 2cm and 2cm × 2cm...
May 15, 2018: Medical Physics
Roland B Sookias
For the first time, a phylogenetic analysis including all putative euparkeriid taxa is conducted, using a large data matrix analysed with maximum parsimony and Bayesian analysis. Using parsimony, the putative euparkeriid Dorosuchus neoetus from Russia is the sister taxon to Archosauria + Phytosauria. Euparkeria capensis is placed one node further from the crown, and forms a euparkeriid clade with the Chinese taxa Halazhaisuchus qiaoensis and 'Turfanosuchus shageduensis' and the Polish taxon Osmolskina czatkowicensis...
March 2016: Royal Society Open Science
Guang-Quan Zhang, Yan-Zheng Gao, Shu-Lian Chen, Shuai Ding, Kun Gao
BACKGROUND: Percutaneous vertebroplasy (PVP) might lead to significant radiation exposure to patients, operators, and operating room personnel. Therefore, radiaton exposure is a concern. The aim of this study was to present a remote control cement delivery device and study whether it can reduce dose exposue to operators. METHODS: After meticulous preoperative preparation, a series of 40 osteoporosis patients were treated with unilateral approach PVP using the new cement delivery divice...
2014: BMC Musculoskeletal Disorders
Melike Sapmaz-Metin, M Kanter, C Uzal
We investigated the effects of ionizing radiation on maturation ability and radiosensitivity of oocytes enclosed in preantral and antral follicles. Balb/c female mice received total body single dose gamma radiation (7.2 Gy) at the diestrous to proestrous transition period. In the first experiment, spontaneously ovulated oocytes were collected from irradiated animals. In the second experiment, irradiated animals were allowed to superovulate to assess the ovarian function. The spontaneous ovulation rate of the follicles exposed at antral stage was significantly lower than the sham-irradiated mice (p < 0...
March 2014: Acta Biologica Hungarica
Subhash Banerjee, Omar Hadidi, Atif Mohammad, Ali Alsamarah, Rahul Thomas, Karan Sarode, Puja Garg, Mirza S Baig, Emmanouil S Brilakis
PURPOSE: To present a systematic safety evaluation of the CrossBoss blunt microdissection catheter for crossing peripheral chronic total occlusions (CTOs). METHODS: Between July 2010 and July 2011, 15 patients (all men; mean age 60.7±9.1 years) underwent endovascular treatment of 17 infrainguinal CTOs that were resistant to guidewire passage, so the blunt microdissection catheter was employed to recanalize the artery. Fourteen lesions were de novo and 3 were in-stent restenoses...
February 2014: Journal of Endovascular Therapy
G V Bondar', V Kh Basheev, S É Zolotukhin, I V Sovpel', O V Sovpel'
The method of combined neoadjuvant treatment of resectable cancer recti, consisting of preoperative radiaton therapy, using big-fractionized intensive irradiation on the endolymphatic chemotherapy background together with fluorouracil with following surgical intervention (main group), in terms up to 72 h, was elaborated in the clinic. The patients, to whom the chemotherapy and radiation therapy were conducted, were included into control groups. Postoperative complications have had occurred in 8 (12.5%) patients of the main group and in 10 (15...
January 2013: Klinichna Khirurhiia
Akiro Kimura
Leukemias including acute myeloid leukemia (AML), acute lymphocytic leukemia, and chronic myeloid leukemia as well as myelodysplastic syndrome (MDS), male non-Hodgkin lymphoma and MGUS are statistically significant radiation-associated hematopoietic neoplasms. Recently, MDS has been confirmed to increase among atomic bomb survivors. AML/RUNX1 is a critical transcription factor of differentiation and proliferation of hematopoietic stem cells. AML1 point mutations, especially N-terminal RUNT domain in-frame type, are frequently detected in radiaton-associated and therapy-related (rad-t-) MDS/AML...
March 2012: Nihon Rinsho. Japanese Journal of Clinical Medicine
Wyndham H Wilson, Sin-Ho Jung, Pierluigi Porcu, David Hurd, Jeffrey Johnson, S Eric Martin, Myron Czuczman, Raymond Lai, Jonathan Said, Amy Chadburn, Dan Jones, Kieron Dunleavy, George Canellos, Andrew D Zelenetz, Bruce D Cheson, Eric D Hsi
BACKGROUND: A phase II trial of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (DA-EPOCH-R) from the National Cancer Institute showed promising activity in untreated diffuse large B-cell lymphoma. The Cancer and Leukemia Group B conducted a study to determine if these results could be reproduced in a multi-institutional setting. DESIGN AND METHODS: The study included 69 patients with untreated diffuse large B-cell lymphoma at least 18 years of age and at least stage II...
May 2012: Haematologica
Rong Yu, Yongheng Li, Guangying Zhu
BACKGROUND AND OBJECTIVE: It has been known that stereotactic radiotherapy has been widely used in clinical practice. The aim of this study is to evaluate the feasibility to treat small lung neoplasms with hypofraction stereotactic radiotherapy. METHODS: From September 2005 to November 2009, 15 patients with non-small cell lung cancer and solitary metastatic lung cancer were treated with hypofraction stereotactic radiotherapy. Dose volume histogram was used to evaluated treatment plans...
March 2011: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Se Youn Jang, Min Ho Kong, Kwan Young Song, John G Frazee
The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report. Seven years ago, a 45 year-old male patient underwent biopsy to confirm pathologic characteristics and received craniocervical radiation and chemotherapy for a grade II astrocytoma in the cervical spinal cord. Two years later, posterior fusion was necessary for progressive kyphosis in the cervical spine. He was well for approximately 7 years after the primary surgery...
June 2009: Journal of Korean Neurosurgical Society
Long Chen, Jacob T Robinson, Michal Lipson
Through full-vectorial simulations and analytical models, we investigate the role of radiation and surface plasmon polaritons (SPP) in the optical interaction between a nano-slit and a parallel nano-groove on a metal surface. We quantitatively confirm the radiaton as the interaction mechanism in perfect electrical conductors (PEC), and verify the role of radiation and SPP in the slit-groove interaction in silver. While the contribution of SPP dominates for the nano-slit and nano-groove placed far apart, the radiation plays a significant role for the nano-slit and nano-groove with smaller separations comparable to one wavelength...
December 25, 2006: Optics Express
I Sirák, J Hatlová, J Petera, M Vosmik, A Ryska, H Vosmiková
Epidermal growth factor receptor (EGFR) plays an important role in cell-cycle regulation, proliferation, differentiation, and surviving of epithelial tissues. Aberrant overexpression of EGFR can initiate uncontrolled cell proliferation with subsequent formation of epithelial carcinomas. Correlation between EGFR overexpression and increased resistance of tumor tissues to ionizing radiation has been described by many authors. Strategy of tumor radiosensitization by EGFR inhibition seems to have a great potential in the treatment of epithelial cancers...
2008: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Chang Wang, Jun Yang, Jihua Nie
Lipidomics, a prominent area of metabolomics, utilizes novel analytical methodologies to study the extensive classes of lipid molecules, changes in lipid metabolism and lipid-mediated signaling processes. In this paper, the phospholipid metabolic profiles changes and potential biomarker identification in the rats plasma after gamma-irradiation exposure were investigated by coupling high performance liquid chromatography-mass spectrometry technology to multivariate statistical analysis. Orthogonal partial least-squares to latent structures discriminate analysis (OPLS-DA) was used to find the potential plasma phospholipids biomarkers of rats for radiation exposure...
October 2009: Biomedical Chromatography: BMC
M M Marchenko, H P Kopyl'chuk, O M Voloshchuk
The work is devoted to investigation of the influence of low doses of preliminary radiation on the fraction content, and oxidizing modification of mitochondrial proteins, unsolvable in 0.05 M sodium-phosphate buffer (11,5), and mtDNA fragmentation. That low-dose irradiation influence mostly manifests itself on the initial stages of tumor growth. It was established that tumor development is accompanied with the changes of mitochondrial proteins fraction content. These changes occured on the intensive oxidizing modification background of the proteins under study and mtDNA fragmentation...
July 2008: Ukraïnsʹkyĭ Biokhimichnyĭ Z︠h︡urnal
G T Mazuzan
No abstract text is available yet for this article.
May 22, 1987: Science
G M Higgins, C Sheard
No abstract text is available yet for this article.
May 25, 1928: Science
Jesús Gómez-Zurita, Toby Hunt, Fatos Kopliku, Alfried P Vogler
BACKGROUND: The great diversity of the "Phytophaga" (weevils, longhorn beetles and leaf beetles) has been attributed to their co-radiation with the angiosperms based on matching age estimates for both groups, but phylogenetic information and molecular clock calibrations remain insufficient for this conclusion. METHODOLOGY: A phylogenetic analysis of the leaf beetles (Chrysomelidae) was conducted based on three partial ribosomal gene markers (mitochondrial rrnL, nuclear small and large subunit rRNA) including over 3000 bp for 167 taxa representing most major chrysomelid lineages and outgroups...
April 11, 2007: PloS One
V V Tsetlin, Iu A Akatov, V V Arkhangel'skiĭ, V G Mitrikas, V A Bondarenko, S A Makin
Dynamics of the ISS RS radiation environment was studied using the data of daily (operative) monitoring and personal dose measurements during 11 increments in the period between August 1, 2000 and October 28, 2005 overlapping the maximum phase of the 23rd solar cycle. It was shown that personal absorbed doses varied within the range of measurements of dual wavelength radiometer R-16, a component of the ISS radiation monitoring system. Power of the absorbed doses fell in the range of 0.017 to 0.02 cGy/day and was solar-dependent...
September 2006: Aviakosmicheskaia i Ekologicheskaia Meditsina, Aerospace and Environmental Medicine
Marcus E Randall, Geoffrey S Ibbott
Intensity Modulated Radiation Therapy (IMRT) is considered a major advance in radiaton therapy (RT) capability. Therefore, it has been rapidly accepted and implemented in the treatment of multiple cancers in which RT plays a major role. Early reports of IMRT in gynecologic cancers have been largely favorable, particularly in terms of decreased acute morbidity. However, IMRT has not been prospectively shown to be superior to conventional 3-dimensional RT techniques when judged against criteria established in advance...
July 2006: Seminars in Radiation Oncology
Mitchell Liu, Tom Pickles, Eric Berthelet, Alexander Agranovich, Winkle Kwan, Scott Tyldesley, Michael McKenzie, Mira Keyes, James Morris, Howard Pai
BACKGROUND AND PURPOSE: To describe the incidence of urinary incontinence among prostate cancer patients treated with external beam radiotherapy (RT) and to investigate associated risk factors. PATIENTS AND METHODS: One thousand and hundred ninety-two patients with >or=24 months follow-up were the subjects of this series. All patients received between 50 and 72 Gy in 20-37 fractions (median 66 Gy/33#). Post-RT urinary incontinence was scored by direct patient interviewing according to the modified RTOG/SOMA scale: Grade 1--occasional use of incontinence pads, Grade 2--intermittent use of incontinence pads, Grade 3--persistent use of incontinence pads, and Grade 4--permanent catheter...
February 2005: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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