keyword
MENU ▼
Read by QxMD icon Read
search

Rate of force production

keyword
https://www.readbyqxmd.com/read/28549242/identification-of-related-substances-in-tofacitinib-citrate-by-lc-ms-techniques-for-synthetic-process-optimization
#1
Xiao Wu, Xuefang Zeng, Lei Wang, Taijun Hang, Min Song
A specific LC-MS method was developed for separation, identification and characterization of the process-related substances and degradation products in tofacitinib citrate. The separation was achieved on a LiChrospher C18 column (250mm×4.6mm, 5μm) by linear gradient elution of 0.1% ammonium acetate solution (pH adjusted to 4.0 by formic acid) and acetonitrile at a flow rate of 1.0mL/min. Forced degradation studies were conducted under hydrolytic (acidic, basic), oxidative, photolytic and thermal stress conditions as described in ICH...
May 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28544042/forced-degradation-studies-of-lansoprazole-using-lc-esi-hrms-and-1-h-nmr-experiments-in-vitro-toxicity-evaluation-of-major-degradation-products
#2
G Shankar, R M Borkar, S Udutha, L Guntuku, V G M Naidu, N Nagesh, R Srinivas
Regulatory agencies from all over the world have set up stringent guidelines with regard to drug degradation products due to their toxic effects or carcinogenicity. Lansoprazole, a proton-pump inhibitor, was subjected to forced degradation studies as per ICH guidelines Q1A (R2). The drug was found to degrade under acidic, basic, neutral hydrolysis and oxidative stress conditions, whereas it was found to be stable under thermal and photolytic conditions. The chromatographic separation of the drug and its degradation products were achieved on a Hiber Purospher, C18 (250 X 4...
May 20, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28540046/evaluation-of-a-novel-technique-in-airway-clearance-therapy-specific-cough-technique-sct-in-cystic-fibrosis-a-pilot-study-of-a-series-of-n-of-1-randomised-controlled-trials
#3
Sandra Gursli, Leiv Sandvik, Egil Bakkeheim, Bjørn Skrede, Britt Stuge
OBJECTIVES: The aim of this pilot study was to evaluate the efficacy, safety and participants' perception of a novel technique in airway clearance therapy - specific cough technique in cystic fibrosis. METHODS: We conducted randomised controlled individual trials (N-of-1 randomised controlled trials) in six adults. Each trial included 8 weeks of treatment with two interventions each week, one with specific cough technique and one with forced expiration technique...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28533383/mechanosensing-of-shear-by-pseudomonas-aeruginosa-leads-to-increased-levels-of-the-cyclic-di-gmp-signal-initiating-biofilm-development
#4
Christopher A Rodesney, Brian Roman, Numa Dhamani, Benjamin J Cooley, Ahmed Touhami, Vernita D Gordon
Biofilms are communities of sessile microbes that are phenotypically distinct from their genetically identical, free-swimming counterparts. Biofilms initiate when bacteria attach to a solid surface. Attachment triggers intracellular signaling to change gene expression from the planktonic to the biofilm phenotype. For Pseudomonas aeruginosa, it has long been known that intracellular levels of the signal cyclic-di-GMP increase upon surface adhesion and that this is required to begin biofilm development. However, what cue is sensed to notify bacteria that they are attached to the surface has not been known...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28528530/evaluation-of-ratite-skinning-force-in-order-to-fix-plant-and-mechanical-solutions
#5
Biagio Bianchi
The skin is the most requested product of ratite slaughter and 'first-rate' ratite's skin has a high economic market. Ostrich hide is tanned in South Africa and sold all over the world. Besides, the ostrich meat is considered a niche production in the marketplace, thus allowing for another pro t for the ostrich breeding. Theorical analysis of skinning process has been carried out, and an automatic measurement system has been designed to record the drawing-force on the animal's body during skinning tests. The aim of this study was to indentify the best animal position and provide values of drawing-force in order to design a speci c machine for ostrich skinning...
May 12, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28509883/deposition-of-visible-light-active-c-doped-titania-films-via-magnetron-sputtering-using-co%C3%A2-as-a-source-of-carbon
#6
Rachan Klaysri, Marina Ratova, Piyasan Praserthdam, Peter J Kelly
Doping of titanium dioxide with p-block elements is typically described as an efficient pathway for the enhancement of photocatalytic activity. However, the properties of the doped titania films depend greatly on the production method, source of doping, type of substrate, etc. The present work describes the use of pulsed direct current (pDC) magnetron sputtering for the deposition of carbon-doped titania coatings, using CO₂ as the source of carbon; ratios of O₂/CO₂ were varied through variations of CO₂ flow rates and oxygen flow control setpoints...
May 16, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28509762/beetroot-juice-increases-human-muscle-force-without-changing-ca2-handling-proteins
#7
Jamie Whitfield, Daniel Gamu, George J F Heigenhauser, Luc J C van Loon, Lawrence L Spriet, A Russell Tupling, Graham P Holloway
Dietary inorganic nitrate (NO3) supplementation improves skeletal muscle (SkM) contractile efficiency, and while rodent literature has suggested improvements in calcium handling or redox modifications as likely explanations, the direct mechanism-of-action in humans remains unknown. PURPOSE: To examine the effects of 7-d of beetroot juice (BRJ) supplementation on SkM contractile characteristics and function. METHODS: Recreationally active males (n=8) underwent transcutaneous electrical muscle stimulation of the vastus lateralis for evaluation of contractile characteristics before (pre) and after (post) 7-d of BRJ supplementation (280 mL/day, ~26 mmol NO3)...
May 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28508404/changes-in-biomechanics-of-skiing-at-maximal-velocity-caused-by-simulated-20-km-skiing-race-using-v2-skating-technique
#8
Olli Ohtonen, Stefan J Lindinger, Caroline Göpfert, Walter Rapp, Vesa Linnamo
This study investigated how the fatigue caused by a 20 km simulated skating cross-country skiing race on snow affects the final spurt performance from a biomechanical perspective. Subjects performed a 100 meter maximal skiing trial before and at the end of the simulated race. Cycle characteristics, ground reaction forces from skis and poles, and muscle activity from eight muscles were recorded during each trial. Results showed that subjects were in a fatigued state after the simulated race manifested by 11...
May 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28498701/fast-low-to-high-confinement-mode-bifurcation-dynamics-in-a-tokamak-edge-plasma-gyrokinetic-simulation
#9
C S Chang, S Ku, G R Tynan, R Hager, R M Churchill, I Cziegler, M Greenwald, A E Hubbard, J W Hughes
Transport barrier formation and its relation to sheared flows in fluids and plasmas are of fundamental interest in various natural and laboratory observations and of critical importance in achieving an economical energy production in a magnetic fusion device. Here we report the first observation of an edge transport barrier formation event in an electrostatic gyrokinetic simulation carried out in a realistic diverted tokamak edge geometry under strong forcing by a high rate of heat deposition. The results show that turbulent Reynolds-stress-driven sheared E×B flows act in concert with neoclassical orbit loss to quench turbulent transport and form a transport barrier just inside the last closed magnetic flux surface...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28488824/effects-of-verbal-encouragement-on-force-and-electromyographic-activations-during-handgrip-exercise
#10
Chama Belkhiria, Giovanni DE Marco, Tarak Driss
BACKGROUND: The aim of the present study was to examine the effects of verbal encouragement on isometric force and associated electromyographic (EMG) parameters during a handgrip task. METHODS: Twenty-three participants (12 women and 11 men) performed maximal voluntary isometric handgrip contractions following three conditions: 1) verbal encouragement (VE) condition: participants executed isometric contractions while being verbally encouraged. 2) non verbal encouragement (nVE) condition: the same starting and stopping signal but without encouragement...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28487761/how-and-why-kinetics-thermodynamics-and-chemistry-induce-the-logic-of-biological-evolution
#11
Addy Pross, Robert Pascal
Thermodynamic stability, as expressed by the Second Law, generally constitutes the driving force for chemical assembly processes. Yet, somehow, within the living world most self-organisation processes appear to challenge this fundamental rule. Even though the Second Law remains an inescapable constraint, under energy-fuelled, far-from-equilibrium conditions, populations of chemical systems capable of exponential growth can manifest another kind of stability, dynamic kinetic stability (DKS). It is this stability kind based on time/persistence, rather than on free energy, that offers a basis for understanding the evolutionary process...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28486578/development-of-a-validated-comparative-stability-indicating-assay-method-for-some-h2-receptor-antagonists
#12
Sameh Ahmed, Salwa R Elshaboury, Niveen A Mohamed, Shereen Farrag
A comparative force degradation high performance thin layer chromatography (HPTLC) method was developed and validated for some H2-receptor antagonists. The studied H2-receptor antagonists were ranitidine (RAN), nizatidine (NIZ) and famotidine (FAM). The degradation behaviors of the studied H2-receptor antagonists were studied under different stress conditions (hydrolytic, thermal and oxidative) conditions as well as storage conditions according to International Conference on Harmonization (ICH) recommendations...
May 9, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28481717/implementation-of-quality-by-design-approach-in-manufacturing-process-optimization-of-dry-granulated-immediate-release-coated-tablets-a-case-study
#13
Michał Teżyk, Emilia Jakubowska, Bartłomiej Milanowski, Janina Lulek
The aim of this study was to optimize the process of tablets compression and identification of film-coating critical process parameters (CPPs) affecting critical quality attributes (CQAs) using Quality by Design approach. Design of experiment (DOE) and regression methods were employed to investigate hardness, disintegration time and thickness of uncoated tablets depending on slugging and tableting compression force (CPPs). Plackett-Burman experimental design was applied to identify critical coating process parameters among selected ones, that is: drying and preheating time, atomization air pressure, spray rate, air volume, inlet air temperature and drum pressure, that may influence the hardness and disintegration time of coated tablets...
May 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28480972/impact-of-fluidic-agitation-on-human-pluripotent-stem-cells-in-stirred-suspension-culture
#14
Daniel Nampe, Ronak Joshi, Kevin Keller, Nicole I Zur Nieden, Hideaki Tsutsui
The success of human pluripotent stem cells (hPSCs) as a source of future cell therapies hinges, in part, on the availability of a robust and scalable culture system that can readily produce a clinically relevant number of cells and their derivatives. Stirred suspension culture has been identified as one such promising platform due to its ease of use, scalability, and widespread use in the pharmaceutical industry (e.g., CHO cell-based production of therapeutic proteins) among others. However, culture of undifferentiated hPSCs in stirred suspension is a relatively new development within the past several years, and little is known beyond empirically optimized culture parameters...
May 8, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28480773/new-gentle-wing-high-shear-granulator-impact-of-processing-variables-on-granules-and-tablets-characteristics-of-high-drug-loading-formulation-using-design-of-experiment-approach
#15
Mohamed H Fayed, Sayed I Abdel-Rahman, Fars K Alanazi, Mahrous O Ahmed, Hesham M Tawfeek, Ramadan I Al-Shdefat
The aim of this work was to study the application of design of experiment (DoE) approach in defining design space for granulation and tableting processes using a novel gentle-wing high shear granulator. According to quality-by-design (QbD) prospective, critical attributes of granules and tablets should be ensured by manufacturing process design. A face centered central composite design has been employed in order to investigate the effect of water amount (X1), impeller speed (X2), wet massing time (X3) and water addition rate (X4) as independent process variables on granules and tablets characteristics...
May 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28474606/asymmetries-in-wing-inertial-and-aerodynamic-torques-contribute-to-steering-in-flying-insects
#16
Mark Jankauski, Thomas Daniel, I Shen
Maneuvering in both natural and artificial miniature flying systems is assumed to be dominated by aerodynamic phenomena. To explore this, we develop a flapping wing model integrating aero and inertial dynamics. The model is applied to an elliptical wing similar to the forewing of the Hawkmoth Manduca sexta and realistic kinematics are prescribed. We explore critically the stroke deviation phase, as it relates to firing latency in airborne insect steering muscles which has been correlated to various aerial maneuvers...
May 5, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28468814/metabolic-cost-of-human-hopping
#17
Anne K Gutmann, John E A Bertram
To interpret the movement strategies employed in locomotion, it is necessary to understand the source of metabolic cost. Muscles must consume metabolic energy to do work, but also must consume energy to generate force. The energy lost during steady locomotion and, hence, the amount of mechanical work muscles need to perform to replace it can be reduced and, in theory, even eliminated by elastically storing and returning some portion of this energy via the tendons. However, even if muscles do not need to perform any mechanical work, they still must generate sufficient force to tension tendons and support body weight...
May 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28467684/cardiac-contractility-motor-function-and-cross-bridge-kinetics-in-n47k-rlc-mutant-mice
#18
Li Wang, Katarzyna Kazmierczak, Chen-Ching Yuan, Sunil Yadav, Masataka Kawai, Danuta Szczesna-Cordary
We have investigated the physiology and mechanical profiles of skinned papillary muscle fibers from transgenic mice expressing the N47K mutation in the myosin regulatory light chain (RLC), shown to cause hypertrophic cardiomyopathy in humans. The results were compared with wild-type (WT) mice, both expressing the human ventricular RLC. Rate constants of a cross-bridge (XB) cycle were deduced from tension transients induced by sinusoidal length changes during maximal Ca(2+) activation, and were studied as a function of MgATP, MgADP, and Pi concentrations...
May 3, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28461504/stability-of-bound-species-during-alkene-reactions-on-solid-acids
#19
Michele L Sarazen, Enrique Iglesia
This study reports the thermodynamics of bound species derived from ethene, propene, n-butene, and isobutene on solid acids with diverse strength and confining voids. Density functional theory (DFT) and kinetic data indicate that covalently bound alkoxides form C-C bonds in the kinetically relevant step for dimerization turnovers on protons within TON (0.57 nm) and MOR (0.67 nm) zeolitic channels and on stronger acids HPW (polyoxometalate clusters on silica). Turnover rates for mixed alkenes give relative alkoxide stabilities; the respective adsorption constants are obtained from in situ infrared spectra...
May 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28459744/electrical-stimulation-of-artificial-heart-muscle-a-look-into-the-electrophysiologic-and-genetic-implications
#20
Mohamed A Mohamed, Jose F Islas, Robert J Schwartz, Ravi K Birla
Development of tissue-engineered hearts for treatment of myocardial infarction or biologic pacemakers has been hindered by the production of mostly arrhythmic or in-synergistic constructs. Electrical stimulation (ES) of these constructs has been shown to produce tissues with greater twitch force and better adrenergic response. To further our understanding of the mechanisms underlying the effect of ES, we fabricated a bioreactor capable of delivering continuous or intermittent waveforms of various types to multiple constructs simultaneously...
May 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
keyword
keyword
114867
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"