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Rate of force production

Hong Yang, Thomas H Marwick, Ying Wang, Mark Nolan, Kazuaki Negishi, Faisal Khan, Peter M Okin
AIMS: The detection of non-ischaemic (mainly hypertension, diabetes, and obesity) stage B heart failure (SBHF) may facilitate the recognition of those at risk of progression to overt HF and HF prevention. We sought the relationship of specific electrocardiographic (ECG) markers of SBHF to echocardiographic features of SBHF and their prognostic value for development of HF. The ECG markers were Cornell product (Cornell-P), P-wave terminal force in lead V1 (PTFV1), ST depression in lead V5 V6 (minSTmV5V6), and increased heart rate...
November 2017: ESC Heart Failure
Juan J Jiménez, Beatriz E Muñoz, María I Sánchez, Rafael Pardo
The fate of the pharmaceutical drugs tenoxicam, piroxicam and meloxicam in river water is evaluated here for first time. So, biological, photochemical and thermal degradation assays have been conducted to estimate their degradation rates and know their degradation products. Results indicated that the direct sunlight irradiation, without any protection, promoted a fast degradation of the oxicams while the chemical reactions in solution were less important. The biological degradation in water was negligible except for tenoxicam in whose case its influence was scarce...
October 25, 2017: Chemosphere
Neal Ingraham Callaghan, Kenneth Javier Williams, J Craig Bennett, Tyson James MacCormack
Silver nanoparticles (nAg), due to their biocidal properties, are common in medical applications and are used in more consumer products than any other engineered nanomaterial. This growing abundance, combined with their ability to translocate across the epithelium and bioaccumulate, suggests that internalized nAg may present a risk of toxicity to many organisms in the future. However, little experimentation has been devoted to cardiac responses to acute nAg exposure, even though nAg is known to disrupt ion channels even when ionic Ag(+) does not...
November 9, 2017: Environmental Pollution
Sudip Nag, Arnab Pramanik, Dhrubajyoti Chattopadhyay, Maitree Bhattacharyya
Microbial synthesis of gold nanoparticles (GNPs) has attracted considerable attention in recent times due to their exceptional capability for the bioremediation of industrial wastes and also for the treatment of wastewater. A bacterial strain Staphylococcus warneri, isolated from the estuarine mangroves of Sundarbans region produced highly stable GNPs by reducing hydrogen auric chloride (HAucl4) salt using intracellular protein extract. The nanoparticles were characterized utilizing ultraviolet-visible spectrophotometry, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, X-ray diffraction, and surface enhanced Raman scattering...
November 9, 2017: Environmental Science and Pollution Research International
Lin-Lin Wang, Qun-Li Yu, Ling Han, Xiu-Li Ma, Ren-De Song, Suo-Nan Zhao, Wen-Hua Zhang
This study investigated the effect of reactive oxygen species-mediated oxidative stress on activation of mitochondrial apoptosis and tenderness of yak meat during postmortem ageing. Oxidative stress degree, Ca(2+) levels, membrane permeability transition pore opening, mitochondrial membrane potential, apoptotic factors and the shear force were examined. Results showed that the ROS generated by H2O2 significantly increased mitochondrial oxidative stress by decreasing the activities of superoxide dismutase, catalase and glutathione peroxidase, and increasing lipid peroxidation...
April 1, 2018: Food Chemistry
William R Wieder, Melannie D Hartman, Benjamin Sulman, Ying-Ping Wang, Charles D Koven, Gordon B Bonan
Emerging insights into factors responsible for soil organic matter stabilization and decomposition are being applied in a variety of contexts, but new tools are needed to facilitate the understanding, evaluation and improvement of soil biogeochemical theory and models at regional to global scales. To isolate the effects of model structural uncertainty on the global distribution of soil carbon stocks and turnover times we developed a soil biogeochemical testbed that forces three different soil models with consistent climate and plant productivity inputs...
November 9, 2017: Global Change Biology
Douglas R Tait, Damien Troy Maher, Wei Wen Wong, Isaac R Santos, Mahmood Sadat-Noori, Ceylena Holloway, Perran Louis Miall Cook
Estuaries are an important source of greenhouse gases to the atmosphere, but uncertainties remain in the flux rates and production pathways of greenhouse gases in these dynamic systems. This study performs simultaneous high resolution measurements of the three major greenhouse gases (carbon dioxide, methane, and nitrous oxide) as well as carbon stable isotope ratios of carbon dioxide and methane, above and below the pycnocline along a salt wedge estuary (Yarra River estuary, Australia). We identified distinct zones of elevated greenhouse gas concentrations...
November 8, 2017: Environmental Science & Technology
Michele Bustamante, Gabrielle Gaustad, Elisa Alonso
Materials criticality assessment is an analytical framework increasingly applied to identify materials of importance to stakeholders who face scarcity risks. Although criticality assessment studies highlight materials for the implicit purpose of informing future action, the aggregated nature of the studies' results make them poorly suited for use as guidance in nuanced strategy development and implementation. As a first step in the selection of mitigation strategies, the present work proposes a modeling framework and accompanying set of metrics to directly compare strategies by measuring effectiveness of risk reduction as a function of features of projected supply-demand balance over time...
November 7, 2017: Environmental Science & Technology
D Mété
BACKGROUND: France has a complex system for the taxation of alcoholic beverages. In the French overseas territories (FOT), the system includes little-known specificities whose purpose is to preserve the sugar-cane-rum sector, a pillar for the weak economies in these territories. Taxes are reduced for traditional rums produced and sold locally. This favors the marketing of alcoholic spirits at low prices. In metropolitan France, on the contrary, spirits are heavily taxed drinks and their share in consumption is minor...
November 2017: Revue D'épidémiologie et de Santé Publique
Zeng-Qiang Wu, Jun-Jun Liu, Jin-Yi Li, Dan Xu, Xing-Hua Xia
Electrochemical biosensors based on enzymatic reaction have been applied to a wide range of fields. As the trend continues to grow, these biosensors are approaching the limit imposed by physics and chemistry. To further improve the performance of biosensors, the interplay of mass transport and enzymatic reaction kinetics, especially in enzyme cascade systems, should be considered in the design of biosensors. Herein, we propose a simple approach to studying the influence of mass transport and enzyme molecule motion on the kinetics of enzyme cascade reactions...
November 15, 2017: Analytical Chemistry
J W Zhou, C L Zhong, H Liu, A A Degen, E C Titgemeyer, L M Ding, Z H Shang, X S Guo, Q Qiu, Z P Li, G Yang, R J Long
Under traditional management on the Qinghai-Tibetan Plateau, yaks () graze only on natural pasture without supplements and are forced to cope with sparse forage of low N content, especially in winter. In contrast, indigenous Tibetan yellow cattle () require supplements during the cold season. We hypothesized that, in response to harsh conditions, yaks cope with low N intakes better than cattle. To test this hypothesis, a study of whole-body N retention and urea kinetics was conducted in 2 concurrent 4 × 4 Latin squares, with 1 square using yaks and 1 square using cattle...
October 2017: Journal of Animal Science
Suyong Kim, Jeongwon Lee, F Lahiji Shayan, Seohyun Kim, Inyoung Huh, Yonghao Ma, Huisuk Yang, Geonwoo Kang, Hyungil Jung
A dissolving microneedle (DMN) patch encapsulated with ascorbic acid 2-glucoside (AA2G) in a needle-shaped hyaluronic acid (HA) backbone was fabricated and sterilized by electron beam (e-beam, 5-40kGy) and gamma ray (γ-ray, 5-30kGy). DMN structures maintained their morphologies and fracture force regardless of e-beam and γ-ray irradiation doses. Both e-beam (40kGy) and γ-ray (20 and 30kGy) met the product sterility requirements for cosmetics and vaccines; however, γ-ray irradiation significantly degraded the encapsulated AA2G, while e-beam maintained AA2G activity...
January 15, 2018: Carbohydrate Polymers
Guoyuan Li, Lei Zhang, Lei Wang, Guangyin Yuan, Kerong Dai, Jia Pei, Yongqiang Hao
Osteoporotic fracture (OPF) remains a major clinical challenge for skeletal regeneration. Impaired osteogenesis and excessive remodeling result in prolonged and poor quality of fracture healing. To augment bone formation and inhibit excessive resorption simultaneously, we constructed a biodegradable magnesium-based implant integrated with the anti-catabolic drug zoledronic acid (ZA); this implant exhibits controllable, sustained release of magnesium degradation products and ZA in vitro. The extracts greatly stimulate the osteogenic differentiation of rat-bone marrow-derived mesenchymal stem cells (rBMSCs), while osteoclastogenesis is inhibited by ZA...
October 24, 2017: Acta Biomaterialia
Safvet Ors
BACKGROUND: Migraine headache is a primary neurologic disease affecting millions of people worldwide. As a consequence, quality of life is diminished, productivity suffers (through loss of work force), and treatment costs are substantial. The occurrence rate in the general population is quite high, with women accounting for 3 of every 4 cases. METHODS: Between January 2011 and May 2012, a total of 221 patients received hair transplants. Another 590 patients underwent hair transplantation between June 2012 and December 2016...
September 2017: Plastic and Reconstructive Surgery. Global Open
Shouryadipta Ghosh, Edmund J Crampin, Eric Hanssen, Vijay Rajagopal
All cells in the body have a specific shape and internal organization which is specific to that cell's function. Heart cells are rod-shaped, and contain arrays of contractile protines (myofibrils) and mitochondria (organelles that produce energy) that are aligned along the length of the rod. This arrangement is presumed to allow the cell to generate maximal contractile force for each heartbeat and for energy metabolites to be readily available to generate this force. Heart disease phenotypes, such as diabetic cardiomyopathy and heart failure, exhibit altered organization of mitochondria...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Karolina A Haupa, Britta A Johnson, Edwin L Sibert, Yuan-Pern Lee
The investigation of partially deuterated methoxy radicals is important because the symmetry lowering from C3v to Cs provides new insights into the couplings between rovibronic states via Jahn-Teller and spin-orbit interactions. The vibrational spectrum of the partially deuterated methoxy radical CH2DO in a matrix of p-H2 has been recorded. This species was prepared by irradiating a p-H2 matrix containing deuterated d1-nitritomethane (CH2DONO) at 3.3 K with laser light at 355 nm. The identification of the radical is based on the photochemical behavior of the precursor and comparison of observed vibrational wavenumbers and infrared (IR) intensities with those predicted from a refined quartic, curvilinear, internal coordinate force field calculated with the coupled-cluster singles and doubles with perturbative triples/cc-pVTZ method...
October 21, 2017: Journal of Chemical Physics
Liao Peiran, Liu Ying, Zhao Mingzhuo, Yang Ye, Cui Xiuming
Panax notoginseng medicinal liquor (PML) has a long history of use in the function of blood circulation. However, the processing of PML is currently dependent on experience, which results in low efficiency and unstable quality of PML. A variety of substances of P. notoginseng have a strong ability to scavenge free radicals and antioxidant activity, but the antioxidant activity of PML has not been formally researched. The aim of the present study was to optimize the processing technology of PML and to verify the anti-oxidation and anti-deposition of melanin functions of PML...
October 20, 2017: Food & Function
Meng Qi, Qilei Song, Junpeng Zhao, Chunfeng Ma, Guangzhao Zhang, Xiangjun Gong
Understanding the behavior of bacteria near biodegradable surfaces is critical for the development of biomedical and antibiofouling materials. By using digital holographic microscopy (DHM), we investigated the three-dimensional (3D) behavior of Escherichia coli and Pseudomonas sp. in lipase-containing aquatic environments near dynamic surfaces constructed by biodegradable poly(ε-caprolactone) (PCL)-based polymers in real time. As the enzymatic degradation rate increases, the percentage of near-surface subdiffusive bacteria and consequently, the irreversible adhesion decreases...
November 1, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Hamed Helisaz, Mohammad Hassan Saidi, Arman Sadeghi
The viscoelasticity effects on the reaction-diffusion rates in a Y-shaped microreactor are studied utilizing the PTT rheological model. The flow is assumed to be fully developed and considered to be created under a combined action of electroosmotic and pressure forces. In general, finite-volume-based numerical simulations are conducted to handle the problem; however, analytical solutions based on the depthwise averaging approach are also obtained for the case for which there is no reaction between the inlet components...
October 16, 2017: Analytica Chimica Acta
Ty B Palmer, Jose G Pineda, Rachel M Durham
This study aimed to examine the effects of knee position on the reliability and production of peak force (PF) and rate of force (RFD) development characteristics during an isometric squat. Fourteen resistance-trained females performed isometric squats at 90, 120, and 150° knee angles (corresponding to parallel, half, and quarter squat positions, respectively) on two different occasions, from which PF, peak RFD, and early (RFD30,RFD50,RFD100) and late (RFD200) phase RFD variables were extracted. PF and RFD200 were highly consistent across trials for all three squat positions, with intraclass correlation coefficients (ICCs) ranging between 0...
October 10, 2017: Journal of Applied Biomechanics
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