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Rate of force production

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https://www.readbyqxmd.com/read/28215633/tlr-4-mirna-32-5p-fstl1-signaling-regulates-mycobacterial-survival-and-inflammatory-responses-in-mycobacterium-tuberculosis-infected-macrophages
#1
Zhi-Min Zhang, Ai-Rong Zhang, Min Xu, Jun Lou, Wei-Qiang Qiu
Macrophages play a pivotal role in host immune response against mycobacterial infection, which is tightly modulated by multiple factors, including microRNAs. The purpose of the present study was to investigate the biological function and potential mechanism of miR-32-5p in human macrophages during Mycobacterium tuberculosis (M.tb) infection. The results demonstrated that miR-32-5p was robustly enhanced in THP-1 and U937 cells in response to M.tb infection. TLR-4 signaling was required for upregulation of miR-32-5p induced by M...
February 16, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28210028/a-preliminary-study-of-the-measurement-of-overload-applied-to-the-foot-support-of-a-wheelchair-and-a-seated-postural-support-device
#2
Satoshi Shirogane, Takashi Handa, Yoshihiko Kozai, Yusuke Maeda
[Purpose] The mechanical strength of wheelchair and seating products is specified by standards to ensure user safety. However, some individual users are affected by severe spasticity resulting from cerebral palsy that occasionally breaks such devices. Until recently, reports of quantitative measurement of these mechanical overloads have been scarce, and the exact loads applied have been unknown. This study aimed to conduct a sampling survey prior to conducting a future full-scale study. [Subjects and Methods] Using two force plates, we measured the load on the foot support applied by three participants with cerebral palsy...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28209743/skeletal-muscle-bioenergetics-during-all-out-exercise-mechanistic-insight-into-the-oxygen-uptake-slow-component-and-neuromuscular-fatigue
#3
Ryan M Broxterman, Gwenael Layec, Thomas J Hureau, Markus Amann, Russell S Richardson
Although commonly used, the physiological mechanisms underlying all-out exercise performance are still unclear and an in-depth assessment of skeletal muscle bioenergetics is lacking. Therefore, phosphorous magnetic resonance spectroscopy ((31)P-MRS) was utilized to assess skeletal muscle bioenergetics during a 5-min all-out intermittent isometric knee-extensor protocol in 8 healthy men. The metabolic perturbation, adenosine triphosphate (ATP) synthesis rates, ATP cost of contraction, and mitochondrial capacity were determined from intramuscular concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), diprotonated phosphate (H2PO4⁻ ), and pH...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28207800/perception-production-relations-in-later-development-of-american-english-rhotics
#4
Tara McAllister Byun, Mark Tiede
It is known that some adult listeners have more sharply defined perceptual categories than others, and listeners with more precise auditory targets are also more precise in their production of contrasts. There is additionally evidence that children who have not yet mastered production of a contrast show diminished performance on perceptual measures of the same contrast. To date, however, few studies have investigated developmental perception-production relations using the fine-grained measures typical of adult studies...
2017: PloS One
https://www.readbyqxmd.com/read/28191929/stop-frame-filming-and-discovery-of-reactions-at-the-single-molecule-level-by-transmission-electron-microscopy
#5
Thomas W Chamberlain, Johannes Biskupek, Stephen T Skowron, Alexander V Markevich, Simon Kurasch, Oliver Reimer, Kate Walker, Graham A Rance, Xinliang Feng, Klaus Müllen, Andrey Turchanin, Maria A Lebedeva, Alexander Majouga, Valentine Georgievich Nenajdenko, Ute Kaiser, Elena Besley, Andrei N Khlobystov
We report an approach - named chemTEM - to follow chemical transformations at the single-molecule level with the electron beam of a transmission electron microscope (TEM) applied as both a tuneable source of energy and a sub-Angstrom imaging probe. Deposited on graphene, disk-shaped perchlorocoronene molecules are precluded from intermolecular interactions. This allows monomolecular transformations to be studied at the single-molecule level in real time and reveals chlorine elimination and reactive aryne formation as a key initial stage of multi-step reactions initiated by the 80 keV e-beam...
February 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28188541/the-impact-of-granule-density-on-tabletting-and-pharmaceutical-product-performance
#6
Sander van den Ban, Daniel J Goodwin
PURPOSE: The impact of granule densification in high-shear wet granulation on tabletting and product performance was investigated, at pharmaceutical production scale. Product performance criteria need to be balanced with the need to deliver manufacturability criteria to assure robust industrial scale tablet manufacturing processes. A Quality by Design approach was used to determine in-process control specifications for tabletting, propose a design space for disintegration and dissolution, and to understand the permitted operating limits and required controls for an industrial tabletting process...
February 10, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28187879/validated-stability-indicating-hplc-dad-method-for-determination-of-the-recently-approved-hepatitis-c-antiviral-agent-daclatasvir
#7
M M Baker, D S El-Kafrawy, M S Mahrous, T S Belal
A comprehensive stability indicating HPLC with diode array detection method was developed for the determination of the recently approved antiviral drug daclatasvir dihydrochloride (DCV) which is used for the treatment of chronic Hepatitis C Virus (HCV) genotype 3 infection. Effective chromatographic separation was achieved using Waters C8 column (4.6×250mm, 5μm particle size) with isocratic elution of the mobile phase composed of mixed phosphate buffer pH 2.5 and acetonitrile in the ratio of 75:25 (by volume)...
February 7, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28182436/kinetics-chemistry-and-morphology-of-syngas-photoinitiated-chemical-vapor-deposition
#8
Donya Farhanian, Gregory De Crescenzo, Jason R Tavares
Syngas is the product of gasification processes and is used for the production of petrochemicals. Little attention has been paid to its use in the production of oligomeric thin films under ambient conditions. Herein, the nature of the photoinitiated chemical vapor deposition of films made from syngas using high-wavelength ultraviolet light is discussed, including an exploration of the oligomeric films' structure, synthesis mechanism, and growth kinetics. Specifically, X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry analyses provide insight into the chemical structure, illustrating the effect of photogenerated radicals in the formation of aliphatic, anhydride, and cyclic structures...
February 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28176368/pharmacological-inhibition-of-myostatin-protects-against-skeletal-muscle-atrophy-and-weakness-after-anterior-cruciate-ligament-tear
#9
Caroline N W Wurtzel, Jonathan P Gumucio, Jeremy A Grekin, Roger K Khouri, Carol S Davis, Alan J Russell, Asheesh Bedi, Christopher L Mendias
Anterior cruciate ligament (ACL) tears are among the most frequent knee injuries in sports medicine, with tear rates in the US up to 250,000 per year. Many patients who suffer from ACL tears have persistent atrophy and weakness even after considerable rehabilitation. Myostatin is a cytokine that directly induces muscle atrophy, and previous studies rodent models and patients have demonstrated an upregulation of myostatin after ACL tear. Using a preclinical rat model, our objective was to determine if the use of a bioneutralizing antibody against myostatin could prevent muscle atrophy and weakness after ACL tear...
February 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28173605/tethered-swimming-for-the-evaluation-and-prescription-of-resistance-training-in-young-swimmers
#10
Marcelo Papoti, Adelino S R da Silva, Carlos Augusto Kalva-Filho, Gustavo Gomes Araujo, Vanessa Santiago, LuizEduardo Barreto Martins, Sérgio Augusto Cunha, Claudio Alexandre Gobatto
The aims of the present study were 1) to evaluate the effects of 11 weeks of a typical free-swimming training program on aerobic and stroke parameters determined in tethered swimming (Study 1; n=13) and 2) to investigate the responses of tethered swimming efforts, in addition to free-swimming sessions, through 7 weeks of training (Study 2; n=21). In both studies, subjects performed a graded exercise test in tethered swimming (GET) to determine anaerobic threshold (AnT), stroke rate at AnT (SRAnT), peak force at GET (PFGET) and peak blood lactate ([La-]GET)...
February 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28171816/the-western-disease-autism-and-somali-parents-embodied-health-movements
#11
Claire Laurier Decoteau
There is some statistical evidence indicating that Somali refugees and immigrants have high rates of autism spectrum disorder (ASD). Somalis in North America call autism the "Western disease" because there is no word for autism in the Somali language and because many believe it does not exist in Somalia. In Toronto, Somali parents have forged an "epistemic community," united around a coherent theory of the development of autism, its defining features, and most successful therapies. They work together with researchers to support the theory that gut bacteria is a causal factor for the development of autism...
February 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28168248/photoinduced-bimolecular-electron-transfer-from-aromatic-amines-to-pentafluorophenyl-porphyrin-combined-with-ultrafast-charge-recombination-persistence-with-marcus-inverted-region
#12
Yeduru Venkatesh, Venkatesan Munisamy, Bheerappagari Ramakrishna, Pippara Hemant Kumar, Haraprasad Mandal, Prakriti Ranjan Bangal
The dynamics of photoinduced bimolecular reductive electron transfer between meso-tetrakis(pentafluorophenyl)porphyrin (H2F20TPP), an acceptor (A), and five aromatic amines (donor (D)) with varying oxidation potentials (aniline (AN), N-methylaniline (MAN), N-ethylaniline (EAN), N,N-dimethylaniline (DMAN) and N,N-diethylaniline (DEAN)) in dichloromethane (DCM) as a solvent as well as in neat donor solvents were investigated by employing nanosecond to femtosecond time-resolved fluorescence spectroscopy and femtosecond time-resolved transient absorption spectroscopy upon S2 excitation of H2F20TPP...
February 7, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28153920/the-liverwort-marchantia-drives-alternative-electron-flow-using-a-flavodiiron-protein-to-protect-psi
#13
Ginga Shimakawa, Kimitsune Ishizaki, Shigeyuki Tsukamoto, Moeko Tanaka, Takehiro Sejima, Chikahiro Miyake
The diffusion efficiency of O2 in atmosphere, like that of CO2, is approximately 10(4) times greater than that in aqueous environments. Consequently, terrestrial photosynthetic organisms need mechanisms to protect against potential oxidative damage. The liverwort Marchantia polymorpha, a basal land plant, has habitats where it is exposed to both water and the atmosphere. Furthermore, like cyanobacteria, M. polymorpha has genes encoding flavodiiron proteins (FLV). In cyanobacteria, FLVs mediate O2-dependent alternative electron flow (AEF) to suppress production of reactive oxygen species...
February 2, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28153598/a-demonstration-of-mixing-robustness-in-a-direct-compression-continuous-manufacturing-process
#14
Wyatt J Roth, Ahmad Almaya, Timothy T Kramer, Jeffrey D Hofer
The purpose of this work was to assess the impact of continuous mixing on tablet critical quality attributes (CQAs) manufactured using a continuous, direct compression process. A nine run design of experiments (DoE) that bracketed the range of commercially relevant mixer speeds, mixer orientations, and mass flow rates was executed using a formulation containing a cohesive drug substance at relatively low drug load. Drug substance dispensed concentration using loss-in-weight feeders was within 1% of target for each experiment with 30 second mass flow relative standard deviation values of 3...
January 30, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28150869/biochemical-markers-of-cartilage-metabolism-are-associated-with-walking-biomechanics-six-months-following-anterior-cruciate-ligament-reconstruction
#15
Brian Pietrosimone, Richard F Loeser, J Troy Blackburn, Darin A Padua, Matthew S Harkey, Laura E Stanley, Brittney A Luc-Harkey, Veronica Ulici, Stephen W Marshall, Joanne M Jordan, Jeffery T Spang
The purpose of our study was to determine the association between biomechanical outcomes of walking gait (peak vertical ground reaction force [vGRF], vGRF loading rate [vGRF-LR] and knee adduction moment [KAM]) six months following anterior cruciate ligament reconstruction (ACLR) and biochemical markers of serum type-II collagen turnover (collagen type-II cleavage product to collagen type-II C-propeptide [C2C:CPII]), plasma degenerative enzymes (matrix metalloproteinase-3 [MMP-3]), and a pro-inflammatory cytokine (interleukin-6 [IL-6])...
February 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28150427/effects-of-intermittent-co2-convection-under-far-infrared-radiation-on-vacuum-drying-of-pre-osmodehydrated-watermelon
#16
Rajat Chakraborty, Pijus Mondal
BACKGROUND: Watermelon, a tropical seasonal fruit with high nutrient content, requires preservation through drying due to its perishable nature. Nevertheless, drying of watermelon through conventional processes has negative impact either on the drying time or on the final product quality. In this work, osmotic dehydration (OD) of watermelon followed by far infrared radiation assisted vacuum-drying (FIRRAVD) was optimised to develop dehydrated watermelon with minimum moisture content. Significantly, during FIRRAVD, an attempt was made to further intensify the drying rate by forced convection through intermittent CO2 injection...
February 2, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28149372/intramuscular-fiber-conduction-velocity-isometric-force-and-explosive-performance
#17
Spyridon Methenitis, Gerasimos Terzis, Nikolaos Zaras, Angeliki-Nikoletta Stasinaki, Nikolaos Karandreas
Conduction of electrical signals along the surface of muscle fibers is acknowledged as an essential neuromuscular component which is linked with muscle force production. However, it remains unclear whether muscle fiber conduction velocity (MFCV) is also linked with explosive performance. The aim of the present study was to investigate the relationship between vastus lateralis MFCV and countermovement jumping performance, the rate of force development and maximum isometric force. Fifteen moderately-trained young females performed countermovement jumps as well as an isometric leg press test in order to determine the rate of force development and maximum isometric force...
June 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28135762/stability-of-doripenem-in-reconstituted-solution-thermal-and-oxidative-decomposition-kinetics-and-degradation-products-by-lc-ms
#18
Fábio de Souza Barbosa, José Pedro Etchepare Cassol, Luiz Alcides das Chagas Batista, Everson Willian Fialho Cordeiro, Marí Castro Santos, Adriana Raffin Pohlmann, Elfrides E S Schapoval, Cássia Virginia Garcia, Andreas Sebastian Loureiro Mendez
An UFLC method applied to quantitation of doripenem in powder for injection was validated. Validation parameters were assayed and a rapid analysis was established by reversed phase system, C18 column endcapped (50 x 4.0 mm, 2.0 µm), mobile phase consisted of phosphoric acid 0.01% (pH 3.8) and acetonitrile (98:02, v/v) and flow rate of 0.4 mL min(-1) . Drug stability was studied through submission to forced conditions, allowing to detect the major degradation products and to establish the kinetics parameters...
January 30, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28131030/experimental-investigation-into-battery-electrode-surfaces-the-distribution-of-liquid-at-the-surface-and-the-emptying-of-pores-during-drying
#19
Stefan Jaiser, Lena Funk, Michael Baunach, Philip Scharfer, Wilhelm Schabel
HYPOTHESIS: Drying constitutes a key step in the production of thin, particulate films as the complex microstructure develops and functional additives redistribute throughout the film, thus shaping the film properties. The onset of pore emptying constitutes a paramount marker in the film formation process as capillary liquid transport emerges. EXPERIMENTS: Film shrinkage, development of surface liquid content and liquid depletion in surface pores of thin films are studied by means of a novel experimental approach, using the example of lithium-ion battery anodes...
May 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28118306/acute-effects-of-stretching-on-leg-and-vertical-stiffness-during-treadmill-running
#20
Panagiotis Pappas, Giorgos P Paradisis, Timothy A Exell, Athanasia Smirniotou, Charilaos Tsolakis, Adamantios Arampatzis
The implementation of static (SS) and dynamic (DS) stretching during warm-up routines produces significant changes in biological and functional properties of the human musculoskeletal system. These properties could affect the leg and vertical stiffness characteristics that are considered important factors for the success of athletic activities. The aim of this study was to investigate the influence of SS and DS on selected kinematic variables, and leg and vertical stiffness during treadmill running. Fourteen males (age: 22...
January 11, 2017: Journal of Strength and Conditioning Research
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