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https://www.readbyqxmd.com/read/28646567/severe-menses-associated-hypertension-successfully-treated-with-gonadotropin-releasing-hormone-agonist
#1
Luke J Laffin, Munnam S Jafar, George L Bakris
A case of a 32-year-old nulliparous white woman referred for a 5-year history of severe hypertension, hypokalemia, and resultant systolic dysfunction is presented. She additionally had a left ventricular ejection fraction of 30% including left ventricular dilation and normal left ventricular mass index, as measured by cardiac magnetic resonance imaging when she initially presented to us. Her history revealed that her severe hypertension episodes were monthly and would occur around the catamenial (menses-associated) time...
June 23, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28646515/alcohol-abstinence-in-patients-surviving-an-episode-of-alcoholic-hepatitis-prediction-and-impact-on-long-term-survival
#2
José Altamirano, Hugo López-Pelayo, Javier Michelena, Patricia D Jones, Lluisa Ortega, Pere Ginès, Juan Caballería, Antoni Gual, Ramón Bataller, Anna Lligoña
Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease. Most studies have focused on short-term prognosis, while factors associated with long-term survival are largely unknown. THE AIMS OF OUR STUDY WERE: 1) to determine the impact of complete abstinence from alcohol on long-term survival and 2) to identify prognostic factors at admission capable of predicting abstinence during long-term follow-up in patients with AH. One hundred and forty-two patients with biopsy-proven AH that survived the first episode were included...
June 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28646426/eftrenonacog-alfa-a-review-in-haemophilia-b
#3
Sheridan M Hoy
Eftrenonacog alfa (Alprolix™) is a recombinant fusion protein comprising human factor IX (FIX) covalently linked to the constant region (Fc) domain of human IgG1 (i.e. rFIXFc). The presence of the Fc domain extends the terminal half-life (t½) of rFIXFc, permitting prolonged treatment intervals. rFIXFc is available for intravenous use for the prophylaxis and treatment of bleeding in patients with haemophilia B. In two multinational, phase III studies in previously treated children, adolescents and adults with severe haemophilia B, rFIXFc prophylaxis resulted in low median annualized bleeding rates (ABRs), and was associated with reductions in median weekly factor consumption and dosing frequency compared with pre-study FIX regimens...
June 23, 2017: Drugs
https://www.readbyqxmd.com/read/28646422/how-to-avoid-and-to-manage-post-operative-complications-in-thyroid-surgery
#4
REVIEW
Matteo Angelo Cannizzaro, Salvatore Lo Bianco, Maria Carolina Picardo, Daniele Provenzano, Antonino Buffone
Complications of thyroidectomy are hypoparathyroidism, recurrent laryngeal nerve palsy, and hemorrhage. These complications have a low incidence. Hypoparathyroidism is the most frequent complication of total thyroidectomy. Its incidence varies between 0.5 and 65%. This complication is also visible after reoperation for recurrent disease and in patients previously treated with radioiodine. Damage to the recurrent laryngeal nerve can be temporary or permanent, unilateral or bilateral. The bilateral lesion, associated with severe episodes of breathlessness, is a rare complication (0...
June 23, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28646400/a-brief-assessment-tool-for-investigating-facets-of-moral-judgment-from-realistic-vignettes
#5
Michael Kruepke, Erin K Molloy, Konrad Bresin, Aron K Barbey, Edelyn Verona
Humans make moral judgments every day, and research demonstrates that these evaluations are based on a host of related event features (e.g., harm, legality). In order to acquire systematic data on how moral judgments are made, our assessments need to be expanded to include real-life, ecologically valid stimuli that take into account the numerous event features that are known to influence moral judgment. To facilitate this, Knutson et al. (in Social Cognitive and Affective Neuroscience, 5(4), 378-384, 2010) developed vignettes based on real-life episodic memories rated concurrently on key moral features; however, the method is time intensive (~1...
June 23, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28646363/the-many-routes-of-mental-navigation-contrasting-the-effects-of-a-detailed-and-gist-retrieval-approach-on-using-and-forming-spatial-representations
#6
Signy Sheldon, Alexa Ruel
Navigated routes can be recalled by remembering a schematic layout or with additional sensory and perceptual details, engaging episodic memory processes. In this study, we contrasted the effects of these remembering approaches on retrieving real-world navigated routes, the impact on flexibly using familiar route information and on learning new spatial representations. In a within-subjects design, participants were oriented to recall familiar routes under two remembering conditions-a detail condition that promoted episodic memory processes and a gist condition in which routes were recalled via schematic processes...
June 23, 2017: Psychological Research
https://www.readbyqxmd.com/read/28646281/relations-between-work-and-upper-extremity-musculoskeletal-problems-uemsp-and-the-moderating-role-of-psychosocial-work-factors-on-the-relation-between-computer-work-and-uemsp
#7
Nektaria Nicolakakis, Susan R Stock, Michal Abrahamowicz, Rex Kline, Karen Messing
PURPOSE: Computer work has been identified as a risk factor for upper extremity musculoskeletal problems (UEMSP). But few studies have investigated how psychosocial and organizational work factors affect this relation. Nor have gender differences in the relation between UEMSP and these work factors  been studied. We sought to estimate: (1) the association between UEMSP and a range of physical, psychosocial and organizational work exposures, including the duration of computer work, and (2) the moderating effect of psychosocial work exposures on the relation between computer work and UEMSP...
June 23, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28646270/release-from-pi-an-analysis-and-a-model
#8
D J K Mewhort, Kevin D Shabahang, D R J Franklin
Recall decreases across a series of subspan immediate-recall trials but rebounds if the semantic category of the words is changed, an example of release from proactive interference (RPI). The size of the rebound depends on the semantic categories used and ranges from 0% to 95%. We used a corpus of novels to create vectors representing the meaning of about 40,000 words using the BEAGLE algorithm. The distance between categories and spread within categories jointly predicted the size of the RPI. We used a holographic model for recall equipped with a lexicon of BEAGLE vectors representing the meaning of words...
June 23, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28646228/coronal-mass-ejections-are-not-coherent-magnetohydrodynamic-structures
#9
M J Owens, M Lockwood, L A Barnard
Coronal mass ejections (CMEs) are episodic eruptions of solar plasma and magnetic flux that travel out through the solar system, driving extreme space weather. Interpretation of CME observations and their interaction with the solar wind typically assumes CMEs are coherent, almost solid-like objects. We show that supersonic radial propagation of CMEs away from the Sun results in geometric expansion of CME plasma parcels at a speed faster than the local wave speed. Thus information cannot propagate across the CME...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646138/uniting-the-neuro-developmental-and-immunological-hypotheses-neuregulin-1-receptor-erbb-and-toll-like-receptor-activation-in-first-episode-schizophrenia
#10
Szabolcs Kéri, Csilla Szabó, Oguz Kelemen
Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated pattern recognition receptors associated with the immune hypothesis (Toll-like receptors, TLRs). We recruited 42 first-episode, drug-naïve patients with schizophrenia and 42 matched healthy control subjects. In monocytes TLR4/TLR5 and ErbB expressions were measured with flow-cytometry...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645967/the-bipolar-illness-onset-study-research-protocol-for-the-bio-cohort-study
#11
Lars Vedel Kessing, Klaus Munkholm, Maria Faurholt-Jepsen, Kamilla Woznica Miskowiak, Lars Bo Nielsen, Ruth Frikke-Schmidt, Claus Ekstrøm, Ole Winther, Bente Klarlund Pedersen, Henrik Enghusen Poulsen, Roger S McIntyre, Flavio Kapczinski, Wagner F Gattaz, Jakob Bardram, Mads Frost, Oscar Mayora, Gitte Moos Knudsen, Mary Phillips, Maj Vinberg
INTRODUCTION: Bipolar disorder is an often disabling mental illness with a lifetime prevalence of 1%-2%, a high risk of recurrence of manic and depressive episodes, a lifelong elevated risk of suicide and a substantial heritability. The course of illness is frequently characterised by progressive shortening of interepisode intervals with each recurrence and increasing cognitive dysfunction in a subset of individuals with this condition. Clinically, diagnostic boundaries between bipolar disorder and other psychiatric disorders such as unipolar depression are unclear although pharmacological and psychological treatment strategies differ substantially...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645961/cognitive-screening-and-behavioural-observation-of-functional-ability-in-patients-with-multiple-episode-schizophrenia-an-exploratory-study
#12
Eva Norlin Bagge, Eva Esbjörnsson, Katharina S Sunnerhagen
OBJECTIVES: To evaluate the usability of a neuropsychological screening instrument and two observation scales of everyday behaviour to describe cognitive and functional capacity of patients with multiepisode schizophrenia and considerable care needs, who frequently refuse to participate in cognitive testing or performance-based functional measurement. SETTING: One psychiatric unit specialised in severe mental illness at the Sahlgrenska University Hospital, Gothenburg, Sweden...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645955/is-there-an-ethnic-variation-in-the-epidemiology-of-gonorrhoea-a-retrospective-population-based-study-from-northern-israel-over-15%C3%A2-years-between-2001-and-2015
#13
Khalaf Kridin, Rami Grifat, Mogher Khamaisi
OBJECTIVE: To investigate the trends in the incidence of gonorrhoea through an extended period of time and to compare the epidemiology of gonorrhoea infection between 2 distinct ethnic groups (Jews and Arabs). DESIGN: A retrospective population-based cohort study was conducted on all consecutive patients diagnosed with gonorrhoea through the years 2001-2015. SETTING: National Department of Epidemiology of the Ministry of Health, Haifa District, Israel...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645923/the-connection-between-acute-otitis-media-and-the-acute-abdomen
#14
Imran Masood, Tami Hendriksz
A female aged 9 years with a recent episode of acute otitis media (AOM) presented to her primary care physician with complaints of severe abdominal pain with right lower quadrant rebound tenderness, suggestive of an acute surgical abdomen. Neurological examination was normal on presentation. She was transferred to the local children's hospital for workup of appendicitis, during which she began exhibiting ataxia and slurred speech. Further evaluation revealed mastoiditis, venous sinus thrombosis and subdural empyema...
June 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28645887/perspectives-of-family-members-on-using-technology-in-youth-mental-health-care-a-qualitative-study
#15
Shalini Lal, Winnie Daniel, Lysanne Rivard
BACKGROUND: Information and communication technologies (ICTs) are increasingly recognized as having an important role in the delivery of mental health services for youth. Recent studies have evaluated young people's access and use of technology, as well as their perspectives on using technology to receive mental health information, services, and support; however, limited attention has been given to the perspectives of family members in this regard. OBJECTIVE: The aim of this study was to explore the perspectives of family members on the use of ICTs to deliver mental health services to youth within the context of specialized early intervention for a first-episode psychosis (FEP)...
June 23, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28645853/anterior-pallidal-deep-brain-stimulation-for-tourette-s-syndrome-a-randomised-double-blind-controlled-trial
#16
Marie-Laure Welter, Jean-Luc Houeto, Stéphane Thobois, Benoit Bataille, Marc Guenot, Yulia Worbe, Andreas Hartmann, Virginie Czernecki, Eric Bardinet, Jerome Yelnik, Sophie Tezenas du Montcel, Yves Agid, Marie Vidailhet, Philippe Cornu, Audrey Tanguy, Solène Ansquer, Nematollah Jaafari, Emmanuel Poulet, Giulia Serra, Pierre Burbaud, Emmanuel Cuny, Bruno Aouizerate, Pierre Pollak, Stephan Chabardes, Mircea Polosan, Michel Borg, Denys Fontaine, Bruno Giordana, Sylvie Raoul, Tiphaine Rouaud, Anne Sauvaget, Isabelle Jalenques, Carine Karachi, Luc Mallet
BACKGROUND: Deep brain stimulation (DBS) has been proposed to treat patients with severe Tourette's syndrome, and open-label trials and two small double-blind trials have tested DBS of the posterior and the anterior internal globus pallidus (aGPi). We aimed to specifically assess the efficacy of aGPi DBS for severe Tourette's syndrome. METHODS: In this randomised, double-blind, controlled trial, we recruited patients aged 18-60 years with severe and medically refractory Tourette's syndrome from eight hospitals specialised in movement disorders in France...
June 20, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28645744/reversible-hemispheric-hypoperfusion-in-two-cases-of-smart-syndrome
#17
Karmen Wai, Anna Balabanski, Nicholas Chia, Timothy Kleinig
Stroke-like migraine attacks after radiation therapy (SMART) syndrome manifests as prolonged episodes of cortical dysfunction, years after cranial irradiation. We present two cases demonstrating reversible hemispheric hypoperfusion. Case 1 presented with left hemispheric symptoms following previous similar episodes. CT perfusion (CTP) demonstrated reversible hemispheric hypoperfusion; subsequent investigations were consistent with SMART syndrome. Case 2 presented following the third episode of a hemispheric syndrome with near-identical CTP abnormalities...
June 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28645616/epidemiological-and-sociodemographic-factors-associated-with-complicated-alcohol-withdrawal-syndrome
#18
R Monte-Secades, M Blanco-Soto, J A Díaz-Peromingo, A Sanvisens-Bergé, M C Martín-González, A Barbosa, B Rosón-Hernández, M A Tejero-Delgado, R Puerta-Louro, R Rabuñal-Rey
OBJECTIVES: To analyse the influence of epidemiological and sociodemographic factors in complicated alcohol withdrawal syndrome (AWS). MATERIAL AND METHODS: A multicentre, observational prospective study was conducted on consecutively added patients with AWS hospitalised in internal medicine departments. We recorded sociodemographic, epidemiological, clinical and progression data. Complicated AWS was defined as that which progressed with seizures or delirium tremens...
June 20, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28645472/bradycardia-syncope-and-left-ventricular-noncompaction-cardiomyopathy
#19
D Luke Glancy, Frederick R Helmcke, Allen P Hoang
A 55-year-old man with syncopal episodes was found to have sinus bradycardia at a rate of 37 beats/min, an episode of nonsustained ventricular tachycardia, and left ventricular noncompaction cardiomyopathy. After placement of a dual-chamber cardioverter defibrillator 4 years ago, he has had no further syncopal episodes, and there have been no defibrillator shocks.
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28645244/evolution-of-the-vertebrate-insulin-receptor-substrate-irs-gene-family
#20
Ahmad Al-Salam, David M Irwin
BACKGROUND: Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3, has been pseudogenized in humans. While it is known that the Irs gene family originated in vertebrates, it is not known when it originated and which members are most closely related to each other. A better understanding of the evolution of Irs genes and proteins should provide insight into the regulation of metabolism by insulin...
June 23, 2017: BMC Evolutionary Biology
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