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https://www.readbyqxmd.com/read/29778210/rabbit-haemorrhagic-disease-cross-protection-and-comparative-pathogenicity-of-gi-2-rhdv2-b-and-gi-1b-rhdv-lagoviruses-in-a-challenge-trial
#1
Carlos Calvete, Manuel Mendoza, Ana Alcaraz, María P Sarto, María P Jiménez-de-Bagüéss, Antonio J Calvo, Fernando Monroy, Jorge H Calvo
European rabbits (Oryctolagus cuniculus) are severely affected by rabbit haemorrhagic disease (RHD). Caused by a lagovirus, the disease leads to losses in the rabbit industry and has implications for wildlife conservation. Past RHD outbreaks have been caused by GI.1/RHDV genotype viruses. A new virus belonging to the GI.2/RHDV2/b genotype emerged in 2010, quickly spreading and replacing the former in several countries; however, limited data are available on its pathogenicity and epidemiological factors. The present work extends these issues and evaluates cross-protection between both genotypes...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29430852/insights-into-the-evolution-of-the-new-variant-rabbit-haemorrhagic-disease-virus-gi-2-and-the-identification-of-novel-recombinant-strains
#2
D Silvério, A M Lopes, J Melo-Ferreira, M J Magalhães, P Monterroso, A Serronha, E Maio, P C Alves, P J Esteves, J Abrantes
Rabbit haemorrhagic disease (RHD) is a viral disease that affects the European rabbit. RHD was detected in 1984 in China and rapidly disseminated worldwide causing a severe decline in wild rabbit populations. The aetiological agent, rabbit haemorrhagic disease virus (RHDV), is an RNA virus of the family Caliciviridae, genus Lagovirus. Pathogenic (G1-G6 or variants GI.1a-GI.1d) and non-pathogenic strains (GI.4) have been characterized. In 2010, a new variant of RHDV, RHDV2/RHDVb/GI.2, was detected in France...
February 11, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29260677/detection-and-circulation-of-a-novel-rabbit-hemorrhagic-disease-virus-in-australia
#3
Jackie E Mahar, Andrew J Read, Xingnian Gu, Nadya Urakova, Roslyn Mourant, Melissa Piper, Stéphanie Haboury, Edward C Holmes, Tanja Strive, Robyn N Hall
The highly virulent rabbit hemorrhagic disease virus (RHDV) has been widely used in Australia and New Zealand since the mid-1990s to control wild rabbits, an invasive vertebrate pest in these countries. In January 2014, an exotic RHDV was detected in Australia, and 8 additional outbreaks were reported in both domestic and wild rabbits in the 15 months following its detection. Full-length genomic analysis revealed that this virus is a recombinant containing an RHDVa capsid gene and nonstructural genes most closely related to nonpathogenic rabbit caliciviruses...
January 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29250929/prior-exposure-to-non-pathogenic-calicivirus-rcv-a1-reduces-both-infection-rate-and-mortality-from-rabbit-haemorrhagic-disease-in-a-population-of-wild-rabbits-in-australia
#4
B D Cooke, R P Duncan, I McDonald, J Liu, L Capucci, G J Mutze, T Strive
Mortality caused by rabbit haemorrhagic disease virus (RHDV) in wild rabbits is reduced in parts of Australia where the related, non-pathogenic calicivirus RCV-A1 is endemic. Laboratory experiments previously showed that prior infection with RCV-A1 enabled rabbits to better withstand subsequent infection with highly virulent RHDV, and this was assumed to explain higher survival. Here, we analyse serological data from the field suggesting that reduced mortality rates among wild rabbits may also result from rabbits previously infected with RCV-A1 having a reduced likelihood of RHDV infection...
April 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29226567/a-strain-specific-multiplex-rt-pcr-for-australian-rabbit-haemorrhagic-disease-viruses-uncovers-a-new-recombinant-virus-variant-in-rabbits-and-hares
#5
R N Hall, J E Mahar, A J Read, R Mourant, M Piper, N Huang, T Strive
Rabbit haemorrhagic disease virus (RHDV, or GI.1) is a calicivirus in the genus Lagovirus that has been widely utilized in Australia as a biological control agent for the management of overabundant wild European rabbit (Oryctolagus cuniculus) populations since 1996. Recently, two exotic incursions of pathogenic lagoviruses have been reported in Australia; GI.1a-Aus, previously called RHDVa-Aus, is a GI.1a virus detected in January 2014, and the novel lagovirus GI.2 (previously known as RHDV2). Furthermore, an additional GI...
April 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29187537/host-specific-glycans-are-correlated-with-susceptibility-to-infection-by-lagoviruses-but-not-with-their-virulence
#6
Ana M Lopes, Adrien Breiman, Mónica Lora, Béatrice Le Moullac-Vaidye, Oxana Galanina, Kristina Nyström, Stephane Marchandeau, Ghislaine Le Gall-Reculé, Tanja Strive, Aleksija Neimanis, Nicolai V Bovin, Nathalie Ruvoën-Clouet, Pedro J Esteves, Joana Abrantes, Jacques Le Pendu
The rabbit hemorrhagic disease virus (RHDV) and the European brown hare syndrome virus (EBHSV) are two lagoviruses from the family Caliciviridae that cause fatal diseases in two leporid genera, Oryctolagus and Lepus , respectively. In the last few years, several examples of host jumps of lagoviruses among leporids were recorded. In addition, a new pathogenic genotype of RHDV emerged and many non-pathogenic strains of lagoviruses have been described. The molecular mechanisms behind host shifts and the emergence of virulence are unknown...
November 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29150915/epidemiology-of-rhdv2-lagovirus-europaeus-gi-2-in-free-living-wild-european-rabbits-in-portugal
#7
C Rouco, J Abrantes, A Serronha, A M Lopes, E Maio, M J Magalhães, E Blanco, J Bárcena, P J Esteves, N Santos, P C Alves, P Monterroso
As the detection of the first outbreak of a novel aetiological agent of rabbit haemorrhagic disease commonly called RHDV2 or RHDVb (Lagovirus europaeus/GI.2, henceforth GI.2) in France in 2010, the virus rapidly spread throughout continental Europe and nearby islands such as Great Britain, Sardinia, Sicily, the Azores and the Canary Islands among others. The outbreaks of this new lagovirus cause important economic losses in rabbitries, and ecological disruptions by affecting the conservation of rabbit-sensitive top predators...
April 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29141631/detection-of-rabbit-haemorrhagic-disease-virus-2-during-the-wild-rabbit-oryctolagus-cuniculus-eradication-from-the-berlengas-archipelago-portugal
#8
F A Abade Dos Santos, C Carvalho, Oliveira Nuno, J J Correia, M Henriques, M C Peleteiro, M Fevereiro, M D Duarte
BACKGROUND: In the regular wildlife monitoring action carried out in the summer of the past few years at the Berlenga Island, wild rabbits (Oryctolagus cuniculus) have been repeatedly found dead. However, the origin of those deaths was never investigated. Our aim was to investigate the cause of death of 11 rabbits collected between April and May 2016. RESULTS: While screening samples from rabbit carcasses for the major viral rabbit pathogens, five tested positive to RHDV2 but all were negative for RHDV and myxoma virus (MYXV)...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29093089/rabbit-haemorrhagic-disease-virus-2-gi-2-is-replacing-endemic-strains-of-rhdv-in-the-australian-landscape-within-18-months-of-its-arrival
#9
Jackie E Mahar, Robyn N Hall, David Peacock, John Kovaliski, Melissa Piper, Roslyn Mourant, Nina Huang, Susan Campbell, Xingnian Gu, Andrew Read, Nadya Urakova, Tarnya Cox, Edward C Holmes, Tanja Strive
Rabbit haemorrhagic disease virus 2 (RHDV2; Lagovirus GI.2) is a pathogenic calicivirus that affects European rabbits ( Oryctolagus cuniculus ) and various hare ( Lepus ) species. GI.2 was first detected in France in 2010 and subsequently caused epidemics in wild and domestic lagomorph populations throughout Europe. In May 2015 GI.2 was detected in Australia. Within 18 months of its initial detection GI.2 had spread to all Australian states and territories and rapidly became the dominant circulating strain, replacing Rabbit haemorrhagic disease virus (RHDV/GI...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29080562/large-scale-lagovirus-disease-outbreaks-in-european-brown-hares-lepus-europaeus-in-france-caused-by-rhdv2-strains-spatially-shared-with-rabbits-oryctolagus-cuniculus
#10
Ghislaine Le Gall-Reculé, Evelyne Lemaitre, Stéphane Bertagnoli, Céline Hubert, Sokunthea Top, Anouk Decors, Stéphane Marchandeau, Jean-Sébastien Guitton
Rabbit haemorrhagic disease virus (RHDV) is a lagovirus that causes rabbit haemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus). In 2010, a new genotype called RHDV2 emerged in France. It exhibits a larger host range than classical RHDV strains by sporadically infecting different hare species, including the European hare (Lepus europaeus). Phylogenetic analyses revealed that closely related RHDV2 strains circulate locally in both hares and rabbits, and therefore that RHDV2 strains infecting hares do not belong to a lineage that has evolved only in this species...
October 28, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29051566/characterization-of-old-rhdv-strains-by-complete-genome-sequencing-identifies-a-novel-genetic-group
#11
Ana M Lopes, Diogo Silvério, Maria J Magalhães, Helena Areal, Paulo C Alves, Pedro J Esteves, Joana Abrantes
Rabbit hemorrhagic disease (RHD) is a veterinary disease that affects the European rabbit and has a significant economic and ecological negative impact. In Portugal, rabbit hemorrhagic disease virus (RHDV) was reported in 1989 and still causes enzootic outbreaks. Several recombination events have been detected in RHDV strains, including in the first reported outbreak. Here we describe the occurrence of recombination in RHDV strains recovered from rabbit and Iberian hare samples collected in the mid-1990s in Portugal...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040958/the-potential-protective-role-of-akropower-against-atrazine-induced-humoral-immunotoxicity-in-rabbits
#12
Ashraf M Morgan, Marwa A Ibrahim, Ahmed M Hussien
Introduction to the herbicide Atrazine (ATR) can bring about immunotoxicity, aside from other unfavorable results for the creature and human wellbeing. We went for clarifying the genotoxic mechanisms required in humoral immunotoxicity of Gesaprim® (ATR) and their constriction by Akropwer. Forty rabbits (1.5kg±20%) were utilized and appointed into 4 equal groups. group 1: control; group 2: Received Atrazine at 1/10 LD50 via food; group 3: Received Akropwer at 1ml/1l/day by means of drinking water; group 4: Received both Atrazine and Akropwer associatively by the same said dosage and course...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29024672/conventional-and-real-time-rt-pcr-assays-for-the-detection-and-differentiation-of-variant-rabbit-hemorrhagic-disease-virus-rhdvb-and-its-recombinants
#13
K P Dalton, J L Arnal, A A Benito, G Chacón, J M Martín Alonso, F Parra
Since its emergence, variant RHDV (RHDVb/RHDV2) has spread throughout the Iberian Peninsula aided by the apparent lack of cross protection provided by classic (genogroup 1; G1) strain derived vaccines. In addition to RHDVb, full-length genome sequencing of RHDV strains has recently revealed the circulation of recombinant viruses on the Iberian Peninsula. These recombinant viruses contain the RHDVb structural protein encoding sequences and the non-structural coding regions of either pathogenic RHDV-G1 strains or non-pathogenic (np) rabbit caliciviruses...
January 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/28941616/elisa-for-detection-of-variant-rabbit-haemorrhagic-disease-virus-rhdv2-antigen-in-liver-extracts
#14
K P Dalton, A Podadera, V Granda, I Nicieza, D Del Llano, R González, J R de Los Toyos, M García Ocaña, F Vázquez, J M Martín Alonso, J M Prieto, F Parra, R Casais
The emergence and rapid spread of variant of the rabbit hemorrhagic disease virus (RHDV2) require new diagnostic tools to ensure that efficient control measures are adopted. In the present study, a specific sandwich enzyme-linked immunosorbent assay (ELISA) for detection of RHDV2 antigens in rabbit liver homogenates, based on the use of an RHDV2-specific monoclonal antibody (Mab) 2D9 for antigen capture and an anti-RHDV2 goat polyclonal antibody (Pab), was developed. This ELISA was able to successfully detect RHDV2 and RHDV2 recombinant virions with high sensitivity (100%) and specificity (97...
January 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/28935204/the-taishan-robinia-pseudoacacia-polysaccharides-enhance-immune-effects-of-rabbit-haemorrhagic-disease-virus-inactivated-vaccines
#15
Shifa Yang, Guiming Li, Zengcheng Zhao, Minyan Feng, Jian Fu, Zhongli Huang, Minxun Song, Shuqian Lin
Robinia pseudoacacia flower, a common component in traditional Chinese medicine, has long been well-known for its high pharmaceutical value. This study aimed to assess the immunopotentiating effects of Taishan Robinia Pseudoacacia polysaccharides (TRPPS) in rabbits inoculated with a rabbit haemorrhagic disease virus (RHDV) inactivated vaccine. The rabbits were administered with the RHDV vaccine in conjunction with varying concentrations of TRPPS, and their blood samples were collected at different time points to analyze the ratio and number of blood lymphocytes...
September 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28815049/multi-target-chimaeric-vlp-as-a-therapeutic-vaccine-in-a-model-of-colorectal-cancer
#16
Braeden Donaldson, Farah Al-Barwani, Simon J Pelham, Katie Young, Vernon K Ward, Sarah L Young
BACKGROUND: Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination is a promising alternative to conventional treatment for colorectal cancer, using vaccines to induce targeted immune responses against tumour-associated antigens. In this study, we have developed chimaeric virus-like particles (VLP), a form of non-infectious non-replicative subunit vaccine consisting of rabbit haemorrhagic disease virus (RHDV) VP60 capsid proteins containing recombinantly inserted epitopes from murine topoisomerase IIα and survivin...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28806910/multi-target-chimaeric-vlp-as-a-therapeutic-vaccine-in-a-model-of-colorectal-cancer
#17
Braeden Donaldson, Farah Al-Barwani, Simon J Pelham, Katie Young, Vernon K Ward, Sarah L Young
BACKGROUND: Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination is a promising alternative to conventional treatment for colorectal cancer, using vaccines to induce targeted immune responses against tumour-associated antigens. In this study, we have developed chimaeric virus-like particles (VLP), a form of non-infectious non-replicative subunit vaccine consisting of rabbit haemorrhagic disease virus (RHDV) VP60 capsid proteins containing recombinantly inserted epitopes from murine topoisomerase IIα and survivin...
August 15, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28780630/binding-of-rabbit-hemorrhagic-disease-virus-like-particles-to-host-histo-blood-group-antigens-is-blocked-by-antisera-from-experimentally-vaccinated-rabbits
#18
Yanhua Song, Zhiyu Fan, Yuanyuan Zuo, Houjun Wei, Bo Hu, Mengmeng Chen, Rulong Qiu, Jiabin Xue, Fang Wang
During infection host histo-blood group antigens (HBGAs) act as attachment factors that interact with rabbit hemorrhagic disease virus (RHDV) and participate in the infectious process. In the present study, baculovirus expressing recombinant RHDV capsid protein (VP60r) as a vaccine immunogen was used to test its antigenicity and immunogenicity via immunization experiments. Each group of rabbits immunized with VP60r was found to be fully protected against RHDV challenge. The duration of immunity of the vaccine following the inoculation of a single dose was determined to be at least 240 days...
November 2017: Archives of Virology
https://www.readbyqxmd.com/read/28763035/a-motif-in-the-f-homomorph-of-rabbit-haemorrhagic-disease-virus-polymerase-is-important-for-the-subcellular-localisation-of-the-protein-and-its-ability-to-induce-redistribution-of-golgi-membranes
#19
Nadya Urakova, Andrew C Warden, Peter A White, Tanja Strive, Michael Frese
Rabbit haemorrhagic disease virus (RHDV) is a calicivirus that infects and frequently kills rabbits. Previously, we showed that the RHDV RNA-dependent RNA polymerase (RdRp) is associated with distinct, but yet uncharacterised subcellular structures and is capable of inducing a redistribution of Golgi membranes. In this study, we identified a partially hidden hydrophobic motif that determines the subcellular localisation of recombinant RHDV RdRp in transfected cells. This novel motif, 189LLWGCDVGVAVCAAAVFHNICY210, is located within the F homomorph, between the conserved F3 and A motifs of the core RdRp domain...
August 1, 2017: Viruses
https://www.readbyqxmd.com/read/28743597/adaptive-diversification-between-the-classic-rabbit-hemorrhagic-disease-virus-rhdv-and-the-rhdva-isolates-a-genome-wide-perspective
#20
Yan Li, Xueping Yao, Ying Li, Feifei Xu, Zexiao Yang
Rabbit haemorrhagic disease virus (RHDV) is a highly infectious pathogen that causes high mortality in wild and domestic rabbits. RHDV could be divided into two subtypes, classic RHDV and RHDVa, which present clear genetic, antigenic, and epidemiological differences. To further understand the nature of the diversity, we performed a genome-wide evolutionary study on the classic RHDV and RHDVa isolates. The results show that RHDV had experienced adaptive diversification with the dividing process of these subtypes...
July 22, 2017: Microbial Pathogenesis
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