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https://www.readbyqxmd.com/read/28299483/an-update-on-the-rabbit-hemorrhagic-disease-virus-rhdv-strains-circulating-in-portugal-in-the-1990s-earliest-detection-of-g3-g5-and-g6
#1
Ana M Lopes, Maria J Magalhães, Paulo C Alves, Pedro J Esteves, Joana Abrantes
Rabbit hemorrhagic disease virus (RHDV) causes devastating effects on European rabbit (Oryctolagus cuniculus) populations in the Iberian Peninsula. According to the information available, only genogroup 1 strains were circulating in Iberian wild rabbits until 2011; the antigenic variant G6 has been sporadically detected in rabbitries since 2007. Here, we show for the first time that G3-G5 strains were already present in mainland Portugal in 1998 and that G6 has been circulating since at least 1999. Moreover, we report a G3-G5 strain from the Azores collected in 1998, which is the likely ancestor of Azorean G3-G5like strains...
March 15, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28288206/an-in-vivo-system-for-directed-experimental-evolution-of-rabbit-haemorrhagic-disease-virus
#2
Robyn N Hall, Lorenzo Capucci, Markus Matthaei, Simona Esposito, Peter J Kerr, Michael Frese, Tanja Strive
The calicivirus Rabbit haemorrhagic disease virus (RHDV) is widely used in Australia as a biocontrol agent to manage wild European rabbit (Oryctolagus cuniculus) populations. However, widespread herd immunity limits the effectiveness of the currently used strain, CAPM V-351. To overcome this, we developed an experimental platform for the selection and characterisation of novel RHDV strains. As RHDV does not replicate in cell culture, variant viruses were selected by serially passaging a highly virulent RHDV field isolate in immunologically naïve laboratory rabbits that were passively immunised 18-24 hours post-challenge with a neutralising monoclonal antibody...
2017: PloS One
https://www.readbyqxmd.com/read/28247488/fast-specific-field-detection-of-rhdvb
#3
K P Dalton, I Nicieza, A Podadera, D de Llano, J M Martin Alonso, J R de Los Toyos, M García Ocaña, F Vázquez-Villa, B Velasco, O Landeta, F Parra
This work describes a simple and rapid test for field detection of the emerging rabbit pathogen RHDVb. The assay is specific for RHDVb, showing no cross-reactivity with other RHDV types giving a specific result in under 10 min using rabbit liquid exudates or liver homogenate samples taken at necropsy.
February 28, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28231031/different-serological-profiles-to-cooccurring-pathogenic-and-nonpathogenic-caliciviruses-in-wild-european-rabbits-oryctolagus-cuniculus-across-australia
#4
Tanya E Cox, June Liu, Remy van de Ven, Tanja Strive
Rabbit hemorrhagic disease virus (RHDV) was released in Australia as a biocontrol agent for wild European rabbits ( Oryctolagus cuniculus ) in 1995-96; however, its effects were variable across Australia with the greatest population reductions seen in lower annual rainfall areas (<400 mm). There is speculation that the reduced effectiveness observed at higher annual rainfall sites is at least partially due to the presence of a nonpathogenic calicivirus (RCV-A1). The RCV-A1 is related to RHDV and confers partial and transient protection against lethal RHDV infection in laboratory tests...
February 23, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28092608/white-and-red-blood-cell-picture-in-rabbits-experimentally-infected-with-strains-of-the-rabbit-haemorrhagic-disease-rhd-virus-without-or-with-variable-haemagglutination-capacity
#5
P Niedźwiedzka-Rystwej, B Tokarz-Deptuła, W Deptuła
The aim of the study was to establish if haemagglutination of rabbit haemorrhagic disease virus (RHDV) affects haematological picture of peripheral blood in rabbits and the pathogenicity of the virus. The study analyzed white and red blood cell picture in rabbits experimentally infected with two non-haemagglutinating (HA-) RHDV strains (Frankfurt and Asturias) and one strain with variable haemagglutination capacity (HA+/-) (Hagenow). Studies with HA- and HA +/- are rare and relate only to 4 HA- strains (2 RHDV: BLA and Rainham; 2 RHDVa: Pv97 and 9905) and 1 HA+/- RHDV strain: ŻD, where less changes in haematological indices and less pathogenicity were observed...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28072826/rna-dependent-rna-polymerases-of-both-virulent-and-benign-rabbit-caliciviruses-induce-striking-rearrangement-of-golgi-membranes
#6
Nadya Urakova, Tanja Strive, Michael Frese
The extremely pathogenic Rabbit haemorrhagic disease virus (RHDV) and the completely benign Rabbit calicivirus (RCV) are closely related members of the genus Lagovirus (family Caliciviridae). The molecular mechanisms that determine the dramatic difference in virulence are unknown, but indirect evidence suggests that different properties of their RNA-dependent RNA polymerases (RdRps) may at least partially be responsible for the contrasting phenotypes. Here we report that the unusual ability of the RHDV RdRp to induce a striking rearrangement of the Golgi network is not specific to RHDV, but a common feature of virulent and benign rabbit caliciviruses alike...
2017: PloS One
https://www.readbyqxmd.com/read/27913973/emergence-of-new-virulent-rabbit-hemorrhagic-disease-virus-strains-in-saudi-arabia
#7
Mahmoud M Ismail, Mahmoud H A Mohamed, Ibrahim M El-Sabagh, Mohamed A Al-Hammadi
Rabbit hemorrhagic disease is an acute fatal highly contagious viral infectious disease that causes high losses among rabbitries. The disease was first reported in China in 1984 and later on in Saudi Arabia in 1996. The aim of this study was to investigate the emergence and pathogenicity of new rabbit hemorrhagic disease virus (RHDV) strains in Saudi Arabia. The pathogenicity was confirmed by inoculation in susceptible rabbits. Three RHDV strains were detected by reverse transcriptase polymerase chain reaction (RT-PCR) using primers targeting VP60 capsid protein gene in infected rabbitries during 2012 and 2013...
February 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27892861/effects-of-myxoma-virus-and-rabbit-hemorrhagic-disease-virus-on-the-physiological-condition-of-wild-european-rabbits-is-blood-biochemistry-a-useful-monitoring-tool
#8
Isabel Pacios-Palma, Simone Santoro, Alejandro Bertó-Moran, Sacramento Moreno, Carlos Rouco
Myxomatosis and rabbit hemorrhagic disease (RHD) are the major viral diseases that affect the wild European rabbit (Oryctolagus cuniculus). These diseases arrived in Europe within the last decades and have caused wild rabbit populations to decline dramatically. Both viruses are currently considered to be endemic in the Iberian Peninsula; periodic outbreaks that strongly impact wild populations regularly occur. Myxoma virus (MV) and rabbit hemorrhagic disease virus (RHDV) alter the physiology of infected rabbits, resulting in physical deterioration...
December 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27871816/experimental-transmission-of-rabbit-haemorrhagic-disease-virus-rhdv-from-rabbit-to-wild-mice-mus-spretus-and-apodemus-sylvaticus-under-laboratory-conditions
#9
Gregorio Rocha, Fernando Alda, Albert Pagés, Tomás Merchán
Rabbit haemorrhagic disease (RHD) is a highly lethal and contagious viral disease that produces haemorrhagic lesions in liver and lungs of domestic and wild rabbits (Oryctolagus cuniculus). This study investigates the transmission of RHDV from infected rabbits to mice, based on the detection of viral RNA. Sixteen wild mice (Mus spretus, n=12 and Apodemus sylvaticus, n=4) were put in contact with nine rabbits inoculated with RHDV. No mice died following exposure to RHDV-infected rabbits or developed macroscopic haemorrhagic lesions...
January 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27834618/assessment-of-a-novel-vaccine-against-rabbit-hemorrhagic-disease-virus-in-young-rabbits
#10
Sonsoles Pacho, Elias Dahdouh, Javier Merino, Monica Suárez
Rabbit hemorrhagic disease virus (RHDVb) is the new variant of the classical RHDV, a virulent pathogen responsible for an acute disease in young rabbits. The virus invades internal organs, especially the liver, spleen, kidneys, and gut; prevents coagulation; and causes liver necrosis. This eventually leads to quick death of the animal because of hemorrhage. In this study, we evaluated the effects of a new vaccine against RHDVb in rabbits at a young age, after experimental infection using four different viral isolates...
December 2016: Viral Immunology
https://www.readbyqxmd.com/read/27811028/vaccines-for-rhdv-2
#11
(no author information available yet)
No abstract text is available yet for this article.
November 5, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27760037/serological-survey-for-rhd-antibodies-in-rabbits-from-two-types-of-rabbit-breeding-farms
#12
A Fitzner, W Niedbalski
Seroprevalence studies of RHDV antibodies in domestic rabbits were conducted between 2008-2014. A total of 12,169 sera from the provinces of central, southern and south-east Poland, including 7,570 samples collected from mixed-breed rabbits reared in smallholder farms and nearly 4,600 sera taken mainly from unvaccinated rabbits kept in industrial farms, were examined using ELISA tests. Additionally, cross-reactivity of selected tested and control archival sera using both classic RHDV and RHDVa antigens was determined by HI assay...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27664029/recombination-between-g2-and-g6-strains-of-rabbit-hemorrhagic-disease-virus-rhdv-in-china
#13
Bo Hu, Fang Wang, Zhiyu Fan, Yanhua Song, Joana Abrantes, Yuanyuan Zuo, Pedro J Esteves
Rabbit hemorrhagic disease (RHD) is an acute fatal disease caused by the lagovirus rabbit hemorrhagic disease virus (RHDV), which was first reported in 1984 in China. Genetic characterization of RHDV has demonstrated that two different genogroups (G2 and G6) are present in China. To gain a better understanding of the molecular evolution of RHDV, we searched for recombination events by analyzing all full-length RHDV capsid VP60 sequences of Chinese isolates belonging to the genogroups 2 and 6. Our results revealed a recombinant origin for the NanBu/China/2011 isolate...
January 2017: Archives of Virology
https://www.readbyqxmd.com/read/27615998/spillover-events-of-infection-of-brown-hares-lepus-europaeus-with-rabbit-haemorrhagic-disease-type-2-virus-rhdv2-caused-sporadic-cases-of-an-european-brown-hare-syndrome-like-disease-in-italy-and-spain
#14
R Velarde, P Cavadini, A Neimanis, O Cabezón, M Chiari, A Gaffuri, S Lavín, G Grilli, D Gavier-Widén, A Lavazza, L Capucci
Rabbit haemorrhagic disease virus (RHDV) is a lagovirus that can cause fatal hepatitis (rabbit haemorrhagic disease, RHD) with mortality of 80-90% in farmed and wild rabbits. Since 1986, RHDV has caused outbreaks in rabbits (Oryctolagus cuniculus) in Europe, but never in European brown hares (Lepus europaeus, EBH). In 2010, a new RHDV-related virus, called RHDV2, emerged in Europe, causing extended epidemics because it largely overcame the immunity to RHDV present in most rabbit populations. RHDV2 also was identified in Cape hare (Lepus capensis subsp...
September 11, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27609534/extensive-characterization-of-a-lentiviral-derived-stable-cell-line-expressing-rabbit-hemorrhagic-disease-virus-vpg-protein
#15
Jie Zhu, Qiuhong Miao, Yonggui Tan, Huimin Guo, Chuanfeng Li, Zongyan Chen, Guangqing Liu
Rabbit hemorrhagic disease virus (RHDV) is an important member of the caliciviridae family. Currently, no suitable tissue culture system is available for proliferating RHDV, which limits the study of its pathogenesis. To bypass this obstacle, we established a cell line, RK13-VPg, stably expressing the VPg gene with a lentivirus packaging system in this study. In addition, the recently constructed RHDV replicon in our laboratory provided an appropriate model for studying the pathogenesis of RHDV without in vitro RHDV propagation and culture...
November 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27598862/development-of-a-vlp-based-vaccine-in-silkworm-pupae-against-rabbit-hemorrhagic-disease-virus
#16
Xuexing Zheng, Shukun Wang, Weijiao Zhang, Xingjian Liu, Yongzhu Yi, Songtao Yang, Xianzhu Xia, Yinv Li, Zhifang Zhang
Rabbit hemorrhagic disease virus (RHDV) is the etiological agent behind rabbit hemorrhagic disease (RHD), which is lethal and contagious in rabbits. The virus does not replicate in cell culture and the only commercial inactivated vaccine available is derived from infected rabbit livers. RHDV capsid protein, VP60, is the main antigen comprising the virion. We used a baculovirus-silkworm pupae system to express VP60, which self-assembled into virus-like particles (VLPs) with a similar size and morphology to RHDV...
November 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27549017/rabbit-hemorrhagic-disease-virus-capsid-a-versatile-platform-for-foreign-b-cell-epitope-display-inducing-protective-humoral-immune-responses
#17
Noelia Moreno, Ignacio Mena, Iván Angulo, Yolanda Gómez, Elisa Crisci, María Montoya, José R Castón, Esther Blanco, Juan Bárcena
Virus-like particles (VLPs), comprised of viral structural proteins devoid of genetic material, are tunable nanoparticles that can be chemically or genetically engineered, to be used as platforms for multimeric display of foreign antigens. Here, we report the engineering of chimeric VLPs, derived from rabbit hemorrhagic disease virus (RHDV) for presentation of foreign B-cell antigens to the immune system. The RHDV capsid comprises 180 copies of a single capsid subunit (VP60). To evaluate the ability of chimeric RHDV VLPs to elicit protective humoral responses against foreign antigens, we tested two B-cell epitopes: a novel neutralizing B-cell epitope, derived from feline calicivirus capsid protein, and a well characterized B-cell epitope from the extracellular domain of influenza A virus M2 protein (M2e)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27516557/advice-on-rhdv-2-for-practices
#18
(no author information available yet)
No abstract text is available yet for this article.
August 13, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27512059/benign-rabbit-caliciviruses-exhibit-evolutionary-dynamics-similar-to-those-of-their-virulent-relatives
#19
Jackie E Mahar, Leila Nicholson, John-Sebastian Eden, Sebastián Duchêne, Peter J Kerr, Janine Duckworth, Vernon K Ward, Edward C Holmes, Tanja Strive
UNLABELLED: Two closely related caliciviruses cocirculate in Australia: rabbit hemorrhagic disease virus (RHDV) and rabbit calicivirus Australia 1 (RCV-A1). RCV-A1 causes benign enteric infections in the European rabbit (Oryctolagus cuniculus) in Australia and New Zealand, while its close relative RHDV causes a highly pathogenic infection of the liver in the same host. The comparison of these viruses provides important information on the nature and trajectory of virulence evolution, particularly as highly virulent strains of RHDV may have evolved from nonpathogenic ancestors such as RCV-A1...
October 15, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27492646/molecular-cloning-of-the-rabbit-interleukin-6-promoter-functional-characterization-of-rabbit-hemorrhagic-disease-virus-response-elements-in-rk-13%C3%A2-cells
#20
Xing Liu, Bo Hu, Fang Wang, Yanhua Song, Zhiyu Fan, Houjun Wei, Rulong Qiu, Weizhong Xu
Infection with rabbit hemorrhagic disease virus (RHDV) can cause acute liver failure (ALF), leading to severe mortality in rabbits. Inflammatory response, especially the expression of inflammatory cytokines such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6, may play major roles in mediating and amplifying the ALF. Among these cytokines, IL-6 is a multifunctional cytokine with a central role in various physiological inflammatory and immunological processes. In this study, we found that RHDV infection significantly upregulated IL-6 gene expression in vivo...
December 2016: Developmental and Comparative Immunology
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