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Anemia in female adults

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https://www.readbyqxmd.com/read/27872734/allogeneic-hematopoietic-stem-cell-transplantation-for-adult-patients-with-fanconi-anemia
#1
Hosein Kamranzadeh Fumani, Mohammad Zokaasadi, Amir Kasaeian, Kamran Alimoghaddam, Asadollah Mousavi, Babak Bahar, Mohammad Vaezi, Ardeshir Ghavamzadeh
BACKGROUND AND OBJECTIVES: Fanconi anemia (FA) is a rare genetic disorder caused by an impaired DNA repair mechanism which leads to an increased tendency toward malignancies and progressive bone marrow failure. The only curative management available for hematologic abnormalities in FA patients is hematopoietic stem cell transplantation (HSCT). This study aimed to report the results of HSCT in adult or adolescent FA patients. PATIENTS AND METHODS: Twenty FA patients with ages of 16 or more who underwent HSCT between 2002 and 2015 enrolled in this study...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27835759/zika-virus-epidemic-in-brazil-i-fatal-disease-in-adults-clinical-and-laboratorial-aspects
#2
Raimunda S S Azevedo, Marialva T Araujo, Arnaldo J Martins Filho, Consuelo S Oliveira, Bruno T D Nunes, Ana C R Cruz, Ana G P A C Nascimento, Rita C Medeiros, Cezar A M Caldas, Fernando C Araujo, Juarez A S Quaresma, Barbara C B Vasconcelos, Maria G L Queiroz, Elizabeth S Travassos da Rosa, Daniele F Henriques, Eliana V P Silva, Jannifer O Chiang, Lívia C Martins, Daniele B A Medeiros, Juliana A Lima, Márcio R T Nunes, Jedson F Cardoso, Sandro P Silva, Pei-Yong Shi, Robert B Tesh, Sueli G Rodrigues, Pedro F C Vasconcelos
BACKGROUND: Zika virus (ZIKV) was first detected in Brazil in May 2015 and the country experienced an explosive epidemic. However, recent studies indicate that the introduction of ZIKV occurred in late 2013. Cases of microcephaly and deaths associated with ZIKV infection were identified in Brazil in November, 2015. OBJECTIVES: To determine the etiology of three fatal adult cases. STUDY DESIGN: Here we report three fatal adult cases of ZIKV disease...
December 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27829033/outcomes-of-nigeria-s-hiv-aids-treatment-program-for-patients-initiated-on-antiretroviral-treatment-between-2004-2012
#3
Ibrahim Dalhatu, Dennis Onotu, Solomon Odafe, Oseni Abiri, Henry Debem, Simon Agolory, Ray W Shiraishi, Andrew F Auld, Mahesh Swaminathan, Kainne Dokubo, Evelyn Ngige, Chukwuemeka Asadu, Emmanuel Abatta, Tedd V Ellerbrock
BACKGROUND: The Nigerian Antiretroviral therapy (ART) program started in 2004 and now ranks among the largest in Africa. However, nationally representative data on outcomes have not been reported. METHODS: We evaluated retrospective cohort data from a nationally representative sample of adults aged ≥15 years who initiated ART during 2004 to 2012. Data were abstracted from 3,496 patient records at 35 sites selected using probability-proportional-to-size (PPS) sampling...
2016: PloS One
https://www.readbyqxmd.com/read/27761403/rangelia-vitalii-in-a-free-ranging-maned-wolf-chrysocyon-brachyurus-and-co-infections
#4
Julia Angélica Gonçalves Silveira, Mirella Lauria D'Elia, Isabela de Oliveira Avelar, Lara Ribeiro de Almeida, Hudson Andrade Dos Santos, Danielle Ferreira de Magalhães Soares, Múcio Flávio Barbosa Ribeiro, Walter Dos Santos Lima, Roselene Ecco
An adult free-ranged female maned wolf was rescued from a periurban area subject to anthropogenic disturbances in the Minas Gerais, Brazil. The animal presented poor body condition and anemia. The clinical condition rapidly deteriorated culminating in dead and a necropsy was performed. The main gross lesions were marked anemia and blood content in the intestines accompanied by many types of parasites. The protozoa Rangelia vitalii was identified by histopathological analysis predominantly within the cytoplasm of endothelial cells of capillaries of the small intestine...
December 2016: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/27760419/relationship-between-anemia-and-serum-concentrations-of-calcium-and-phosphorus-in-advanced-non-dialysis-dependent-chronic-kidney-disease
#5
Mauro Boronat, Ángelo Santana, Elvira Bosch, Dionisio Lorenzo, Marta Riaño, César García-Cantón
BACKGROUND/AIMS: Different biochemical abnormalities of metabolic bone disease have been associated with anemia of chronic kidney disease (CKD), mainly in hemodialysis patients. However, all of these abnormalities are closely inter-related and their individual effect on the development of anemia is uncertain. This study was aimed to assess the relationship between anemia and a set of metabolic bone disease biomarkers in a cohort of adult patients with advanced non-dialysis-dependent CKD...
October 20, 2016: Nephron
https://www.readbyqxmd.com/read/27755346/extra-intestinal-manifestations-of-celiac-disease-effectiveness-of-the-gluten-free-diet
#6
Hilary Jericho, Naire Sansotta, Stefano Guandalini
OBJECTIVE: To evaluate the effectiveness of the GFD on extra-intestinal symptoms in pediatric and adult celiac populations at the University of Chicago (UofC). METHODS: We conducted a retrospective chart review of the UofC Celiac Center clinic charts from January 2002 to October 2014. Demographics, serologic testing, intestinal biopsies, and extra-intestinal symptoms at presentation, 12, 24, and greater than 24 months were recorded. Extra-intestinal symptoms included: abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis (DH), alopecia, fatigue, headache, anemia, stomatitis, myalgias, psychiatric disorders, rashes, seizures, neuropathy, short stature, delayed puberty, osteoporosis and infertility...
October 13, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27733425/cardiovascular-dysfunction-and-frailty-among-older-adults-in-the-community-the-aric-study
#7
Wilson Nadruz, Dalane Kitzman, Beverly Gwen Windham, Anna Kucharska-Newton, Kenneth Butler, Priya Palta, Michael E Griswold, Lynne E Wagenknecht, Gerardo Heiss, Scott D Solomon, Hicham Skali, Amil M Shah
BACKGROUND: The contribution of cardiovascular dysfunction to frailty in older adults is uncertain. This study aimed to define the relationship between frailty and cardiovascular structure and function, and determine whether these associations are independent of coexisting abnormalities in other organ systems. METHODS: We studied 3,991 older adults (mean age 75.6±5.0 years; 59% female) from the Atherosclerosis Risk in Communities (ARIC) Study in whom the following six organ systems were uniformly assessed: cardiac (by echocardiography), vascular (by ankle-brachial-index and pulse-wave-velocity), pulmonary (by spirometry), renal (by estimated glomerular filtration rate), hematologic (by hemoglobin), and adipose (by body mass index and bioimpedance)...
October 12, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27696475/a-randomized-and-double-blind-controlled-trial-evaluating-the-safety-and-efficacy-of-rituximab-for-warm-auto-immune-hemolytic-anemia-in-adults-the-raiha-study
#8
Marc Michel, Louis Terriou, Francoise Roudot-Thoraval, Mohamed Hamidou, Mikael Ebbo, Guillaume Le Guenno, Lionel Galicier, Sylvain Audia, Bruno Royer, Anne-Sophie Morin, Jean Marie Michot, Arnaud Jaccard, Laurent Frenzel, Mehdi Khellaf, Bertrand Godeau
This Phase 3 multicentre randomized double-blind and placebo-controlled trial aimed to compare the efficacy and safety of rituximab (RTX) to placebo for treating newly diagnosed warm autoimmune hemolytic anemia (wAIHA) in adults receiving prednisone. Adults with a confirmed diagnosis of wAIHA who previously received corticosteroids for less than 6 weeks could be included. At inclusion, all patients received prednisone at a daily dose of 1 mg/kg for 2 weeks, and then tapered according to a pre-defined recommended reduction scheme...
October 3, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27691938/medical-management-of-coelomic-distention-abnormal-swimming-substrate-retention-and-hematologic-changes-in-a-reef-manta-ray-manta-alfredi
#9
Alexa J McDermott, Cara L Field, Lisa A Hoopes, Tonya M Clauss
An adult, female, reef manta ray (Manta alfredi) was evaluated for abnormal swimming and coelomic distention after colliding with a floating dock in an exhibit. Initial clinical signs included abnormal posture and swimming. Clinical signs progressed to include muscle wasting, poor body condition, and coelomic distention. Further diagnostics revealed excessive exhibit substrate within the gastrointestinal tract, gastric ulcers, free coelomic fluid, possible spinal lesion, possible uterine abnormality, and hematologic changes...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27686852/clinical-course-of-two-children-with-unstable-hemoglobins-the-effect-of-hydroxyurea-therapy
#10
Harriët M Loovers, Nienke Tamminga, André B Mulder, Rienk Y J Tamminga
Case reports on the effect of hydroxyurea (HU) therapy for unstable hemoglobins (Hbs) are sparse; only three adult cases have been reported. We report for the first time on the effect of HU therapy in children carrying unstable Hbs. The first case concerns a female child with a familial history of chronic hemolytic anemia. She was diagnosed with Hb Volga (HBB: c.83C>A) at the age of 7 months. At age 6, treatment options were reconsidered due to increasing fatigue and decreasing Hb concentration. The second case also concerns a female child with chronic hemolytic anemia and icterus since the age of 5...
September 30, 2016: Hemoglobin
https://www.readbyqxmd.com/read/27592085/all-payer-analysis-of-heart-failure-hospitalization-30-day-readmission-comorbidities-matter
#11
Jonathan D Davis, Margaret A Olsen, Kerry Bommarito, Shane J LaRue, Mohammed Saeed, Michael W Rich, Justin M Vader
BACKGROUND: Thirty-day readmission following heart failure hospitalization impacts hospital performance measures and reimbursement. We investigated readmission characteristics and the magnitude of 30-day hospital readmissions after hospital discharge for heart failure using the Healthcare Cost and Utilization Project State Inpatient Databases (SID). METHODS: Adults aged ≥ 40 years hospitalized with a primary discharge diagnosis of heart failure from 2007-2011 were identified in the California, New York, and Florida SIDs...
August 31, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27578976/higher-minor-hemoglobin-a2-levels-in-multiple-sclerosis-patients-correlate-with-lesser-disease-severity
#12
Muhammed Emin Ozcan, Bahri Ince, Hasan Huseyin Karadeli, Asuman Gedikbasi, Talip Asil, Meric A Altinoz
OBJECTIVE: To define whether minor adult hemoglobin A2 (HbA2, α2δ2) exerts any protective activity in multiple sclerosis (MS). METHODS: HbA2 levels were measured in 146 MS patients with high performance liquid chromatography and association with MS Severity Scores (MSSS) were determined. HbA2 associations with blood count parameters were also studied using blood counts evaluated on the same day of high performance liquid chromatography sampling. Routine biochemical parameters were also determined to rule out elusively influential factors, such as anemia and thyroid disorders...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27576956/pediatric-crohn-s-disease-iron-deficiency-anemia-and-intravenous-iron-treatment-a-follow-up-study
#13
Sara Valério de Azevedo, Catarina Maltez, Ana Isabel Lopes
BACKGROUND AND AIMS: Increasing evidence in adults demonstrates efficacy and safety of IV iron in inflammatory Bowel disease (IBD) associated iron deficiency anemia; however, evidence in pediatric patients is yet scarce and no previous study has included a long follow-up. This study aimed to evaluate safety and efficacy of IV iron (primary end point), and the need of re-treatment (secondary end point), in this setting. METHODS: Prospective recruitment (40 months); PCDAI determined before and after treatment; anemia defined according to WHO criteria; IV iron treatment included iron sucrose and ferric carboxymaltose...
August 31, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27533797/retinopathy-of-vivax-malaria-in-adults-and-its-relation-with-severity-parameters
#14
Anju Kochar, Paavan Kalra, Vijeth Sb, Vinayak Ukirade, Anita Chahar, Dhanpat Kumar Kochar, Sanjay Kumar Kochar
Malarial retinopathy is a set of retinal signs in severe malaria due to falciparum malaria. With increased recognition of severe manifestations of vivax malaria, a systematic study to evaluate retinal changes in vivax malaria could elaborate our knowledge about this neglected entity. This observational study included retinal examination of 104 adult patients (>14 years) with varying severity of vivax malaria admitted to a tertiary care center during peak seasons of 2012 and 2013. Thirty-eight percent of severe cases had a retinal sign as compared to 6% of non-severe cases (p < 0...
June 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27455820/intracranial-hemorrhage-in-patients-with-hematologic-disorders-prevalence-and-predictive-factors
#15
Weerapat Owattanapanich, Chirayu U Auewarakul
BACKGROUND: Intracranial hemorrhage (ICH) is an uncommon complication in patients with hematologic disorders although high fatality rates have been shown in these patients. At present, no epidemiological data regarding ICH in patients with hematologic disorders has been collected and/or reported in Thailand. OBJECTIVE: The purpose of this study was to determine the incidence of ICH in hospitalized patients with hematologic disorders and to identify predictive factors associated with ICH in these patients...
January 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27447289/hematopoietic-stem-cell-transplant-in-adolescent-and-young-adults-with-fanconi-anemia-is-feasible-with-acceptable-toxicity-with-those-surviving-100-days-posttransplant-having-excellent-outcomes
#16
Ahmad Alhuraiji, Hazza Alzahrani, Fahad Al Mohareb, Naeem Chaudhri, Fahad Alsharif, Said Mohamed, Walid Rasheed, Ghuzayel Aldawsari, Syed Osman Ahmed, Mahmoud Aljurf
OBJECTIVES: Fanconi anemia is a congenital bone marrow failure syndrome that is associated with congenital anomalies and increased risk of cancer. Hematopoietic stem cell transplant is a potentially curative modality for bone marrow failure in Fanconi anemia patients. Here, we report our center's experience regarding adolescent and young adult patients with Fanconi anemia and hematopoietic stem cell transplant. MATERIALS AND METHODS: We conducted a retrospective patient record analyses of patients who presented at our center from 1988 to 2014...
July 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27443031/supported-or-stigmatised-the-impact-of-sickle-cell-disease-on-families
#17
Brigid Keane, Lindy Defoe
Caring for a child with a chronic medical condition can be stressful for parents and likely to have an impact on family dynamics. In a low-prevalence region, services to support parents of children with sickle cell disease (SCD) are limited and consequently parents can feel isolated. We explored this issue in a service evaluation, using semi-structured questionnaires to interview twelve families who had a child with SCD. Our analysis outlines the impact that this condition has on family life and the importance that cultural values and perspectives have in learning to deal with the issues involved...
June 2016: Community Practitioner: the Journal of the Community Practitioners' & Health Visitors' Association
https://www.readbyqxmd.com/read/27438279/iron-deficiency-in-adolescents-and-young-adults
#18
W L Risser, J M Risser, B Goldberg
In brief After childhood, iron deficiency is mainly a problem in females, but it also occurs in males aged 11 to 14 years. Inadequate dietary intake of iron is the major cause of iron deficiency, but factors such as gastrointestinal (GI) blood loss may contribute to this problem. Mild anemia may impair sports performance, and some research suggests that iron deficiency without anemia also has an adverse effect. The diagnosis of iron deficiency should be based on the patient's serum ferritin and hemoglobin concentrations...
December 1990: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/27382938/anemia-outcome-after-laparascopic-mini-bypass%C3%A2-analysis-of-107-consecutive-patients
#19
S Mokhber, P Nikoyan, A Kabir, F Jesmi, M Pishgahroudsari, M Abdolhosseini, P Alibeigi, M Rezvani, A Pazouki
BACKGROUND: The prevalence of obesity has dramatically increased globally. Weight loss procedures are known to be an effective and reliable method with relatively low complication rate and satisfactory results. Laparoscopic mini-gastric bypass (LMGB) is known as a modified Mason loop procedure with compatible results to laparoscopic Roux-en-Y gastric bypass (LRYGB), and is believed to have even less complication rate. Despite adequate and meticulous supplement therapy, anemia is one of the challenges in patients undergoing LMGB...
April 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27353709/the-status-and-associated-factors-of-successful-aging-among-older-adults-residing-in-longevity-areas-in-china
#20
Wen Hui Shi, Hong Yan Zhang, Juan Zhang, Yue Bin Lyu, Melanie Sereny Brasher, Zhao Xue Yin, Jie Si Luo, Dong Sheng Hu, Lei Fen, Xiao Ming Shi
OBJECTIVE: This study aims to assess the status of successful aging (SA) in longevity areas in China and explore multiple factors associated with SA among the young-old and oldest-old. METHODS: A total of 2296 elderly people aged 65 and older were interviewed in the longevity areas sub-sample of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2012. Baseline assessments included a researcher-administered questionnaire, physical examination, and laboratory testing...
May 2016: Biomedical and Environmental Sciences: BES
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