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https://www.readbyqxmd.com/read/29785434/integration-of-phospholipid-hyaluronic-acid-methotrexate-nanocarrier-assembly-and-amphiphilic-drug-drug-conjugate-for-synergistic-targeted-delivery-and-combinational-tumor-therapy
#1
Yang Li, Huabing Zhang, Yilin Chen, Jinyuan Ma, Jinyan Lin, Yinying Zhang, Zhongxiong Fan, Guanghao Su, Liya Xie, Xuan Zhu, Zhenqing Hou
Combinational cancer therapy has been considered as a promising strategy to achieve synergetic therapeutic effects and suppression of multidrug resistance. Herein, we adopted a combination of methotrexate (MTX), an antimetabolite acting on cytoplasm, and 10-hydroxycamptothecin (HCPT), an alkaloid acting on nuclei, to treat cancer. Given the different solubilities, membrane permeabilities, and anticancer mechanisms of both drugs, we developed a dual-targeting delivery system based on 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-hyaluronic acid (a principal ligand of CD44 receptors)-MTX (a selective ligand of folate receptors) nanoparticles, which was exploited to carry HCPT-MTX conjugate for synergistically boosting dual-drug co-delivery...
May 22, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29778505/novel-peptide-nanoparticle-biased-antagonist-of-ccr3-blocks-eosinophil-recruitment-and-airway-hyperresponsiveness
#2
Milica Grozdanovic, Kimberly G Laffey, Hazem Abdelkarim, Ben Hitchinson, Anantha Harijith, Hyung-Geon Moon, Gye Young Park, Lee K Rousslang, Joanne C Masterson, Glenn T Furuta, Nadya I Tarasova, Vadim Gaponenko, Steven J Ackerman
BACKGROUND: Chemokine signaling through CCR3 is a key regulatory pathway for eosinophil recruitment into tissues associated with allergic inflammation and asthma. To date, none of the CCR3 antagonists have shown efficacy in clinical trials. One reason may be their unbiased mode of inhibition that prevents receptor internalization, leading to drug tolerance. OBJECTIVE: We sought to develop a novel peptide nanoparticle CCR3 inhibitor (R321) with a biased mode of inhibition that would block G-protein signaling, but enable or promote receptor internalization...
May 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29775819/facile-synthesis-of-yolk-shell-structured-monodisperse-mesoporous-organosilica-nanoparticles-by-a-mild-alkalescent-etching-approach
#3
Jun Tao, Meng Dang, Xiaodan Su, Qing Hao, Junjie Zhang, Xiaobo Ma, Guangming Lu, Yunlei Zhang, Ying Tian, Lixing Weng, Zhaogang Teng, Lianhui Wang
In the work, yolk-shell structured mesoporous organosilica nanoparticles (YSMONs) are successfully prepared by a mild alkalescent etching approach. The method is very convenient, in which mesostructured organosilica nanospheres are directly transformed into yolk-shell structures after etching with mild alkalescent solution (e.g. sodium carbonate solution). The prepared YSMONs have ethane-bridged frameworks, a monodisperse diameter (320 nm), a large pore volume (1.0 cm3  g-1 ), a uniform mesopore (2.4 nm) and a high surface area (1327 m2  g-1 )...
May 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29775813/hyaluronate-lactoferrin-layer-by-layer-coated-lipid-nanocarriers-for-targeted-co-delivery-of-rapamycin-and-berberine-to-lung-carcinoma
#4
Dalia M Kabary, Maged W Helmy, Kadria A Elkhodairy, Jia-You Fang, Ahmed O Elzoghby
The self-tumor targeting polymers, lactoferrin (LF) and hyaluronic acid (HA) were utilized to develop layer-by-layer (LbL) lipid nanoparticles (NPs) for dual delivery of berberine (BER) and rapamycin (RAP) to lung cancer. To control its release from the NPs, BER was hydrophobically ion paired with SLS prior to incorporation into NPs. Spherical HA/LF-LbL-RAP-BER/SLS-NPs 250.5 nm in diameter, with a surface charge of -18.5 mV were successfully elaborated. The NPs exhibited sequential release pattern with faster release of BER followed by controlled release of RAP which enables sensitization of lung tumor cells to the anti-cancer action of RAP...
May 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29775731/targeted-and-controlled-drug-delivery-by-multifunctional-mesoporous-silica-nanoparticles-with-internal-fluorescent-conjugates-and-external-polydopamine-and-graphene-oxide-layers
#5
Anh-Vy Tran, KyuHwan Shim, Thu-Thao Vo Thi, Jeong-Keun Kook, Seong Soo A An, Sang-Wha Lee
This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene oxide (GO) layers. The brush-like internal conjugates conferred fluorescent functionality and high capacity of cisplatin loading into MSNs, as well as contributing to a sustained release of the cisplatin through a porous channel with the assistance of external PDA layer...
May 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29773873/therapeutic-nanoparticles-penetrate-leaves-and-deliver-nutrients-to-agricultural-crops
#6
Avishai Karny, Assaf Zinger, Ashima Kajal, Janna Shainsky-Roitman, Avi Schroeder
As the world population grows, there is a need for efficient agricultural technologies to provide global food requirements and reduce environmental toll. In medicine, nanoscale drug delivery systems grant improved therapeutic precision by overcoming biological barriers and enhancing drug targeting to diseased tissues. Here, we loaded nanoscale drug-delivery systems with agricultural nutrients, and applied them to the leaves of tomato plants. We show that the nanoparticles - liposomes composed of plant-derived lipids, penetrate the leaf and translocate in a bidirectional manner, distributing to other leaves and to the roots...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772710/effective-nimn-nanoparticles-functionalized-carbon-felt-as-an-effective-anode-for-direct-urea-fuel-cells
#7
Nasser A M Barakat, Mohannad Alajami, Zafar Khan Ghouri, Saeed Al-Meer
The internal resistances of fuel cells strongly affect the generated power. Basically, in the fuel cell, the anode can be prepared by deposition of a film from the functional electrocatalyst on a proper gas diffusion layer. Accordingly, an interfacial resistance for the electron transport is created between the two layers. Electrocatalyst-functionalized gas diffusion layer (GDL) can distinctly reduce the interfacial resistance between the catalyst layer and the GDL. In this study, NiMn nanoparticles-decorated carbon felt is introduced as functionalized GDL to be exploited as a ready-made anode in a direct urea fuel cell...
May 16, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29771490/photo-responsive-nanovehicle-for-two-independent-wavelength-light-triggered-sequential-release-of-p-gp-shrna-and-doxorubicin-to-optimize-and-enhance-synergistic-therapy-of-multidrug-resistant-cancer
#8
Ming Wu, Xinyi Lin, Xionghong Tan, Jiong Li, Zuwu Wei, Da Zhang, Youshi Zheng, Ai-Xian Zheng, Bixing Zhao, Yongyi Zeng, Xiaolong Liu, Jingfeng Liu
Pre-release of RNA molecules than chemotherapeutic drugs with a sufficient interval is a vital prerequisite for RNA/drug co-delivery strategy to overcome multidrug resistance (MDR) of cancer cells, but how to precisely control their release at different time points is still a grand challenge up to now. This study aims to on-demand remotely manipulate RNA and drug release in real time through single delivery system to sequentially play their respective roles for optimizing and enhancing their synergistic antitumor effects...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29768238/one-pot-green-fabrication-of-metallic-silver-nanoscale-materials-using-crescentia-cujete-l-and-assessment-of-their-bactericidal-activity
#9
Seetharaman Prabukumar, Chandrasekaran Rajkuberan, Gnanasekar Sathishkumar, Mani Illaiyaraja, Sivaperumal Sivaramakrishnan
In this study, the leaf extract of an important medicinal plant Crescentia cujete L. (CC) was employed as a green reducing agent to synthesise highly-stable C. cujete silver nanoparticles (CCAgNPs). The reduction of Ag+ to Ag0 nanoparticles was initially observed by a colour change which generates an intense surface plasmon resonance peak at 417 nm using a UV-Vis spectrophotometer. Various optimisation factors such as temperature, pH, time and the stoichiometric proportion of the reaction mixture were performed, which influence the size, dispersity and synthesis rate of CCAgNPs...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29767505/tuned-density-of-anti-tissue-factor-antibody-fragment-onto-sirna-loaded-polyion-complex-micelle-for-optimizing-targetability-into-pancreatic-cancer-cells
#10
Hyun Su Min, Hyun Jin Kim, Jooyeon Ahn, Mitsuru Naito, Kotaro Hayashi, Kazuko Toh, Beob Soo Kim, Yasuhiro Matsumura, Ick Chan Kwon, Kanjiro Miyata, Kazunori Kataoka
Antibody fragment (Fab')-installed polyion complex (PIC) micelles were constructed to improve targetability of small interfering RNA (siRNA) delivery to pancreatic cancer cells. To this end, we synthesized a block copolymer of azide-functionalized poly(ethylene glycol) (PEG) and poly(L-lysine) (PLL), and prepared PIC micelles with siRNA. Then, a dibenzylcyclooctyne (DBCO)-modified anti-human tissue factor (TF) Fab' was conjugated to azido groups on the micellar surface. A fluorescence correlation spectroscopic (FCS) analysis revealed that 1, 2, or 3 molecule(s) of Fab'(s) were installed onto one micellar nanoparticle according to the feeding ratio of Fab' (or DBCO) to micelle (or azide)...
May 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29765515/cancer-cell-selective-clathrin-mediated-endocytosis-of-aptamer-decorated-nanoparticles
#11
Shira Engelberg, Julia Modrejewski, Johanna G Walter, Yoav D Livney, Yehuda G Assaraf
Lung cancer is the leading cause of cancer mortality worldwide, resulting in 88% deaths of all diagnosed patients. Hence, novel therapeutic modalities are urgently needed. Single-stranded oligonucleotide-based aptamers (APTs) are excellent ligands for tumor cell targeting. However, the molecular mechanisms underlying their internalization into living cells have been poorly studied. Towards the application of APTs for active drug targeting to cancer cells, we herein studied the mechanism underlying S15-APT internalization into human non-small cell lung cancer A549 cells...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29763442/platinum-corrosion-products-from-electrode-contacts-of-human-cochlear-implants-induce-cell-death-in-cell-culture-models
#12
Kirsten Wissel, Gudrun Brandes, Nils Pütz, Gian Luigi Angrisani, Jan Thieleke, Thomas Lenarz, Martin Durisin
Despite the technological progress made with cochlear implants (CI), impedances and their diagnosis remain a focus of interest. Increases in impedance have been related to technical defects of the electrode as well as inflammatory and/or fibrosis along the electrode. Recent studies have demonstrated highly increased impedances as the result of corroded platinum (Pt) electrode contacts. This in vitro study examined the effects of Pt ions and compounds generated by corrosion of the electrode contacts of a human CI on cell metabolism...
2018: PloS One
https://www.readbyqxmd.com/read/29762138/theranostic-gold-magnetite-hybrid-nanoparticles-for-mri-guided-radiosensitization
#13
Devid Maniglio, Filippo Benetti, Luca Minati, Jorge Jovicich, Aldo Valentini, G Speranza, Claudio Migliaresi
The main limitation of drug-enhanced radiotherapy concerns the difficulty to evaluate the effectiveness of cancer targeting after drug administration hindering the standardization of therapies based on current radiosensitizing compounds. The challenge regards the development of systems able to combine imaging and radiotherapy enhancement in order to perform highly reliable cancer theragnosis. For these reasons, gold-magnetite hybrid nanoparticles are proposed as innovative theranostic nanotools for imaging-guided radiosensitization in cancer treatment...
May 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29761789/ph-and-redox-responsive-nanoparticles-composed-of-charge-reversible-pullulan-based-shells-and-disulfide-containing-poly-%C3%AE-amino-ester-cores-for-co-delivery-of-gene-and-chemotherapeutic-agent
#14
Sipei Zhang, Dan Wang, Yating Li, Ling Li, Hongli Chen, Qingqing Xiong, Yuan-Yuan Liu, Yingsong Wang
A novel pH- and redox-responsive nanoparticle system was designed based on charge-reversible pullulan derivative (CAPL) and disulfide-containing poly(β-amino ester) (ssPBAE) for the co-delivery of gene and chemotherapeutic agent targeting hepatoma. The end-alkene groups of ssPBAE were reacted with diethylenetriamine to form amino-modified ssPBAE (NH-ssPBAE). Methotrexate (MTX), a chemotherapy agent, was then conjugated to NH-ssPBAE via amide bond to obtain a polymeric prodrug ssPBAE-MTX. ssPBAE-MTX exhibited a good capability for condensing genes including plasmid DNA (pDNA) and tetramethyl rhodamine-labeled DNA (TAMRA-DNA), and almost completely condensed pDNA at the weight ratio of 5/1 to form spherical nanocomplexes with an uniform size...
May 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29758159/redox-responsive-micellar-nanoparticles-from-glycosaminoglycans-for-cd44-targeted-drug-delivery
#15
Ana M Carvalho, Raquel Teixeira, Ramon Novoa-Carballal, Ricardo A Pires, Rui L Reis, Iva Pashkuleva
Cancer progression is associated with overexpression of various receptors at the cell surface. Among these, CD44 is known to recognize and bind specifically hyaluronan (HA) and interact with less affinity to other glycosaminoglycans (GAGs), such as chondroitin sulfate (CS). In this study, we describe a simple method to obtain micellar nanoparticles with GAGs shell (HA or CS) as potential drug delivery systems that target cancer cells overexpressing CD44. Alkane thiol was conjugated at the reducing end of the respective GAG using highly efficient oxime chemistry...
May 14, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29756603/solid-lipid-nanoparticles-release-dna-upon-endosomal-acidification-in-human-embryonic-kidney-cells
#16
Allan Radaic, Marcelo B de Jesus
Nanotechnology can produce materials with unique features compared to the bulk counterparts, which can be useful for medical applications (i.e., nanomedicine). Among the therapeutic agents used in nanomedicine, small molecules or biomacromolecules, such as proteins or genetic materials, can be designed for disease diagnostics and treatment. To transport these biomacromolecules to the target cells, nanomedicine requires nanocarriers. Solid lipid nanoparticles (SLNs) are one of the promising nanocarriers available, because they can be made of biocompatible materials and present high stability (over one year)...
May 14, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29756442/modulation-of-cellular-uptake-of-dna-origami-through-control-over-mass-and-shape
#17
Maartje Bastings, Frances Anastassacos, Nandhini Ponnuswamy, Franziska Leifer, Garry Cuneo, Chenxiang Lin, Donald E Ingber, Ju Hee Ryu, William M Shih
Designer nanoparticles with controlled shape and size are increasingly popular vehicles for therapeutic delivery due to their enhanced cell delivery performance. However, our ability to fashion nanoparticles has offered only limited control over these parameters. Structural DNA nanotechnology has an unparalleled ability to self-assemble three-dimensional nanostructures with near-atomic resolution features and thus, it offers an attractive platform for systematic exploration of the parameter space relevant to nanoparticle uptake by living cells...
May 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/29753904/sorbitan-ester-nanoparticles-sens-as-a-novel-topical-ocular-drug-delivery-system-design-optimization-and-in-vitro-ex-vivo-evaluation
#18
Jesus Alvarez-Trabado, Antonio López-García, Manuel Martín-Pastor, Yolanda Diebold, Alejandro Sanchez
We explored the potential of two types of sorbitan ester nanoparticles (SENS) as novel tools for topical ocular drug delivery. The optimized SENS formulation (SENS-OPT) consisted of nanoparticles (NPs) of 170.5 nm, zeta potential +33.9 mV, and cyclosporine loading of 19.66%. After hyaluronic acid (HA) coating, the resulting SENS-OPT-HA NPs had a particle size of 177.6 nm and zeta potential of -20.6 mV. The NPs were stable during 3 months of storage at different temperatures and did not aggregate in the presence of protein-enriched simulated lacrimal fluid...
May 10, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29745729/anti-proliferate-and-apoptosis-triggering-potential-of-methotrexate-transferrin-conjugate-encapsulated-plga-nanoparticles-with-enhanced-cellular-uptake-by-high-affinity-folate-receptors
#19
Ankush Parmar, Atul Jain, Shivani Uppal, S K Mehta, Khuswinder Kaur, Bhupinder Singh, Rajat Sandhir, Shweta Sharma
The objective of the present study is to enhance the permeation of bioactive molecules across highly lipophilic insurmountable blood brain barrier (BBB) using folic acid (FA) functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles (FA-PNPs) coated with non-ionic surfactant, Polysorbate 80 (P80 ). The developed Mtx-Tf loaded folic acid anchored PNPs formulation depicted particle size, zeta potential and entrapment efficiency of 109 ± 2.3 nm, -9.38 ± 0.9 mV and 71.0 ± 0.6%, respectively...
May 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29745638/maghemite-nanoparticles-with-enhanced-magnetic-properties-one-pot-preparation-and-ultrastable-dextran-shell
#20
Riccardo Di Corato, Alessandra Aloisi, Simona Rella, Jean-Marc Greneche, Giammarino Pugliese, Teresa Pellegrino, Cosimino Malitesta, Rosaria Rinaldi
In the field on nanomedicine, superparamagnetic nanoparticles are one of the most studied nanomaterials for theranostics. In this paper, a one-pot synthesis of magnetic nanoparticles is presented, with elevated control on particles size from 10 to 40 nm. The monitoring of vacuum level is here introduced as a crucial parameter for achieving a fine particle morphology. Magnetic properties of these nanoparticles are highly affected by disorders or mismatches in crystal structure. A prolonged oxidation step is applied to the obtained nanoparticles to transform the magnetic phases into a pure maghemite one, confirmed by a high resolution XPS analysis, by Mössbauer spectrometry and, indirectly, by increased performances in magnetization curves and in relaxation times...
May 10, 2018: ACS Applied Materials & Interfaces
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