keyword
https://read.qxmd.com/read/38533688/-in-vitro-evaluation-of-physicochemical-dependent-effects-of-polymeric-nanoparticles-on-their-cellular-uptake-and-co-localization-using-pulmonary-calu-3-cell-lines
#1
JOURNAL ARTICLE
Nashwa Osman, Paul Curley, Helen Box, Neill Liptrott, Darren Sexton, Imran Saleem
OBJECTIVE: The study evaluated physicochemical properties of eight different polymeric nanoparticles (NPs) and their interaction with lung barrier and their suitability for pulmonary drug delivery. METHODS: Eight physiochemically different NPs were fabricated from Poly lactic-co-glycolic acid (PLGA, PL) and Poly glycerol adipate-co-ω-pentadecalactone (PGA-co-PDL, PG) via emulsification-solvent evaporation. Pulmonary barrier integrity was investigated in vitro using Calu-3 under air-liquid interface...
March 27, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38530045/membrane-free-selective-semi-hydrogenation-of-alkynes-over-an-in-situ-formed-copper-nanoparticle-electrode
#2
JOURNAL ARTICLE
Pengyu Guo, Yousen Xu, Hao Wu, Lei Zhang
Selective semi-hydrogenation of alkynes is a significant reaction for preparing functionalized alkenes. Electrochemical semi-hydrogenation presents a sustainable alternative to the traditional thermal process. In this research, affordable copper acetylacetonate is employed as a catalyst precursor for the electrocatalytic hydrogenation of alkynes, using MeOH as the hydrogen source in an undivided cell. Good to excellent yields for both aromatic and aliphatic internal/terminal alkynes are obtained under constant current conditions...
March 26, 2024: Small
https://read.qxmd.com/read/38527676/research-progresses-on-carboxymethyl-xanthan-gum-review-of-synthesis-physicochemical-properties-rheological-characterization-and-applications-in-drug-delivery
#3
REVIEW
Pallabita Rakshit, Tapan Kumar Giri, Kaushik Mukherjee
Xanthan gum is a nonionic polysaccharide widely explored in biomedical, nutraceutical, and pharmaceutical fields. XG suffers from several drawbacks like poor dissolution, lower bioavailability and an inability to form hydrogels. The carboxymethyl derivative of XG, CMX, has better solubility, dissolution, and bioavailability characteristics. Moreover, due to its anionic character, it forms water insoluble hydrogels upon crosslinking with metal cations. CMX hydrogels are used to prepare matrix tablets, microparticles, beads, and films...
March 23, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38527565/ultrasound-imaging-guided-targeted-sonodynamic-therapy-enhanced-by-magnetophoretically-controlled-magnetic-microbubbles
#4
JOURNAL ARTICLE
Yao Zhu, Gulzira Arkin, Tianzhen He, Fengjuan Guo, Ling Zhang, Yu Wu, Paras N Prasad, Zhongjian Xie
Sonodynamic therapy (SDT) utilizes ultrasonic excitation of a sensitizer to generate reactive oxygen species (ROS) to destroy tumor. Two dimensional (2D) black phosphorus (BP) is an emerging sonosensitizer that can promote ROS production to be used in SDT but it alone lacks active targeting effect and showed low therapy efficiency. In this study, a stable dispersion of integrated micro-nanoplatform consisting of BP nanosheets loaded and Fe3 O4 nanoparticles (NPs) connected microbubbles was introduced for ultrasound imaging guided and magnetic field directed precision SDT of breast cancer...
March 23, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38525014/influence-of-different-ratios-of-dspe-peg2k-on-ester-prodrug-self-assembly-nanoparticles-for-cell-migration-and-proliferation-suppression
#5
JOURNAL ARTICLE
Huiyun Zhang, Shunru Wei, Yunfei Hu, Yu Zhang, Hao Yao, Gang Qi, Michael Adu-Frimpong, Congyong Sun
BACKGROUND: Bufalin (BFL, an active anti-tumor compound derived from toad venom ) is limited in its application due to high toxicity and rapid metabolism of the cardiotonic steroid. Ester prodrug self-assembly nanoparticles have shown significant improved effects in addressing the above-mentioned issues. METHODS: An ester bond was formed between linoleic acid and bufalin to synthesize linoleic acid-bufalin prodrug (LeB). The self-assembly nanoparticles (LeB-PSNs) containing different mass ratios of DSPE-PEG2k and prodrug (6:4, 7:3, 8:2, 9:1 and 10:0) were prepared via co-precipitation method and defined as 6:4-PSNs, 7:3-PSNs, 8:2-PSNs, 9:1-PSNs and LeB-PSNs, respectively...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38525013/nano-drug-delivery-systems-targeting-cafs-a-promising-treatment-for-pancreatic-cancer
#6
REVIEW
Mingjie Wang, Wenxiang Xue, Hanghang Yuan, Zhicheng Wang, Lei Yu
Currently, pancreatic cancer (PC) is one of the most lethal malignant tumors. PC is typically diagnosed at a late stage, exhibits a poor response to conventional treatment, and has a bleak prognosis. Unfortunately, PC's survival rate has not significantly improved since the 1960s. Cancer-associated fibroblasts (CAFs) are a key component of the pancreatic tumor microenvironment (TME). They play a vital role in maintaining the extracellular matrix and facilitating the intricate communication between cancer cells and infiltrated immune cells...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38525008/il-12-overexpressed-nanoparticles-suppress-the-proliferation-of-melanoma-through-inducing-icd-and-activating-dc-cd8-t-and-cd4-t-cells
#7
JOURNAL ARTICLE
Huan-Huan Shen, Jie-Fei Peng, Ran-Ran Wang, Ping-Yu Wang, Jia-Xiang Zhang, Hong-Fang Sun, Yan Liang, Yan-Mei Li, Jiang-Nan Xue, You-Jie Li, Guang-Bin Sun, Shu-Yang Xie
PURPOSE: The drug resistance and low response rates of immunotherapy limit its application. This study aimed to construct a new nanoparticle (CaCO3 -polydopamine-polyethylenimine, CPP) to effectively deliver interleukin-12 (IL-12) and suppress cancer progress through immunotherapy. METHODS: The size distribution of CPP and its zeta potential were measured using a Malvern Zetasizer Nano-ZS90. The morphology and electrophoresis tentative delay of CPP were analyzed using a JEM-1400 transmission electron microscope and an ultraviolet spectrophotometer, respectively...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38522695/a-novel-pectin-polysaccharide-from-vinegar-baked-radix-bupleuri-absorbed-by-microfold-cells-in-the-form-of-nanoparticles
#8
JOURNAL ARTICLE
Ya Zhao, Ping Li, Xiaoshuang Wang, Yayun Wu, Lijuan Liu, Ruizhi Zhao
Polysaccharides of vinegar-baked Radix Bupleuri (VBCP) have been reported to exhibit liver-targeting and immunomodulatory activities through oral administration, but the absorption behavior and mechanism of VBCPs have not been extensively studied. In this study, a novel HG type pectin polysaccharide, VBCP1-4, with a high molecular weight of 2.94 × 106  Da, was separated from VBCP. VBCP1-4 backbone was contained 1,4-α-D-GalpA,1,4-α-D-GalpA6OMe,1,3,4-α-D-GalpA and 1, 2, 4-α-D-Rhap...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38522491/surface-modification-of-hollow-gold-nanoparticles-conducted-by-incorporating-cancer-cell-membrane-and-as1411-aptamer-aiming-to-achieve-a-dual-targeted-therapy-for-colorectal-cancer
#9
JOURNAL ARTICLE
Sepideh Hassibian, Seyed Mohammad Taghdisi, Zahra Jamshidi, Ali Samie, Morteza Alinezhad Nameghi, Mersedeh Shayan, Naser Farrokhi, Mona Alibolandi, Mohammad Ramezani, Seyed Mohsen Dehnavi, Khalil Abnous
Due to its inherent membrane structure, a nanostructure enveloped by an active cell membrane possesses distinctive characteristics such as prolonged presence in the bloodstream, precise identification capabilities, and evasion of immune responses. This research involved the production of biomimetic nanoparticles, specifically hollow gold nanoparticles (HGNPs) loaded with methotrexate (MTX), which were further coated with cancer cell membrane. These nanoparticles were then adorned with AS1411 aptamer to serve as a targeting agent (Apt-CCM-HG@MTX)...
March 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38521374/biodegradable-zwitterionic-polymer-cloaked-defective-metal-organic-frameworks-for-ferroptosis-inducing-cancer-therapy
#10
JOURNAL ARTICLE
Minghua Zhang, Xianxian Yao, Jian Xu, Jiaying Song, Shuting Mai, Weichu Zhu, Yichen Zhang, Liangliang Zhu, Wuli Yang
Ferroptosis inhibits tumor growth by iron-dependently accumulating lipid peroxides (LPO) to a lethal extent, which can result from iron overload and glutathione peroxidase 4 (GPX4) inactivation. In this study, we developed biodegradable zwitterionic polymer-cloaked atorvastatin (ATV)-loaded ferric metal-organic frameworks (Fe-MOFs) for cancer treatment. Fe-MOFs served as nanoplatforms to co-deliver ferrous ions and ATV to cancer cells; the zwitterionic polymer membrane extended the circulation time of the nanoparticles and increased their accumulation at tumor sites...
March 21, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38521320/broad-spectrum-nano-bactericide-utilizing-antimicrobial-peptides-and-bimetallic-cu-ag-nanoparticles-anchored-onto-multiwalled-carbon-nanotubes-for-sustained-protection-against-persistent-bacterial-pathogens-in-crops
#11
JOURNAL ARTICLE
Weimin Ning, Xiangwen Luo, Yu Zhang, Peijie Tian, Youlun Xiao, Shijun Li, Xiao Yang, Fan Li, Deyong Zhang, Songbai Zhang, Yong Liu
Worldwide crop yields are threatened by persistent pathogenic bacteria that cause significant damage and jeopardize global food security. Chemical pesticides have shown limited effectiveness in protecting crops from severe yield loss. To address this obstacle, there is a growing need to develop environmentally friendly bactericides with broad-spectrum and sustained protection against persistent crop pathogens. Here, we present a method for preparing a nanocomposite that combines antimicrobial peptides (AMPs) and bimetallic Cu-Ag nanoparticles anchored onto multiwalled carbon nanotubes (MWCNTs)...
March 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38521307/nitric-oxide-releasing-thiolated-starch-nanoparticles-embedded-in-gelatin-sponges-for-wound-dressing-applications
#12
JOURNAL ARTICLE
Niyousha Davari, Jhamak Nourmohammadi, Javad Mohammadi
This study introduces a novel wound dressing by combining nitric oxide-releasing thiolated starch nanoparticles (NO-TS NPs) with gelatin. First, starch was thiolated (TS), and then its nanoparticles were prepared (TS NPs). Subsequently, NPs were covalently bonded to sodium nitrite to obtain NO-releasing TS NPs (NO-TS-NPs) that were incorporated into gelatin sponges at various concentrations. The resulting spherical TS NPs had a mean size of 85.42 ± 5.23 nm, which rose to 100.73 ± 7...
March 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38518964/engineering-aspects-of-lipid-based-delivery-systems-in-vivo-gene-delivery-safety-criteria-and-translation-strategies
#13
REVIEW
Ismail Eş, Aneesh Thakur, Amin Mousavi Khaneghah, Camilla Foged, Lucimara Gaziola de la Torre
Defects in the genome cause genetic diseases and can be treated with gene therapy. Due to the limitations encountered in gene delivery, lipid-based supramolecular colloidal materials have emerged as promising gene carrier systems. In their non-functionalized form, lipid nanoparticles often demonstrate lower transgene expression efficiency, leading to suboptimal therapeutic outcomes, specifically through reduced percentages of cells expressing the transgene. Due to chemically active substituents, the engineering of delivery systems for genetic drugs with specific chemical ligands steps forward as an innovative strategy to tackle the drawbacks and enhance their therapeutic efficacy...
March 20, 2024: Biotechnology Advances
https://read.qxmd.com/read/38518871/co-delivery-of-paclitaxel-atovaquone-quercetin-to-regulate-energy-metabolism-to-reverse-multidrug-resistance-in-ovarian-cancer-by-plga-peg-nanoparticles
#14
JOURNAL ARTICLE
Qingyu Lu, Wenhao Gao, Zhenzhen Chen, Zhihong Liu, Jie Wang, Lingjun Zeng, Xiaomu Hu, Enqin Zheng, Qian Zhang, Hongtao Song
Ovarian cancer is a malignant tumor that seriously endangers the lives of women, with chemotherapy being the primary clinical treatment. However, chemotherapy encounters the problem of generating multidrug resistance (MDR), mainly due to drug efflux induced by P-glycoprotein (P-gp), which decreases intracellular accumulation of chemotherapeutic drugs. The drugs efflux mediated by P-gp requires adenosine triphosphate (ATP) hydrolysis to provide energy. Therefore, modulating energy metabolism pathways and inhibiting ATP production may be a potential strategy to reverse MDR...
March 20, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38513893/go-agnw-aided-sustained-release-of-ciprofloxacin-loaded-in-starch-pva-nanocomposite-mats-for-wound-dressings-application
#15
JOURNAL ARTICLE
Negar Hosseini Darabi, Mohammad Reza Kalaee, Saeedeh Mazinani, Ramin Khajavi
Compared to conventional bandages, which do not meet all wound care requirements, nanofiber wound dressings could provide a potentially excellent environment for healing. In the present research, nanocomposite membrane based on starch (St) - polyvinyl alcohol (PVA) nanofibers containing ciprofloxacin antibiotic drug loaded on graphene oxide‑silver nanowire (GO-AgNWs) hybrid nanoparticles is produced by electrospinning process. Morphological studies showed that the length and diameter of silver nanowires are 21 ± 9...
March 19, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38510794/the-dual-angiogenesis-effects-via-nrf2-ho-1-signaling-pathway-of-melatonin-nanocomposite-scaffold-on-promoting-diabetic-bone-defect-repair
#16
JOURNAL ARTICLE
Tingting Chen, Zimei Wu, Qiaodan Hou, Yixin Mei, Kunkun Yang, Jing Xu, Lin Wang
PURPOSE: Given the escalating prevalence of diabetes, the demand for specific bone graft materials is increasing, owing to the greater tendency towards bone defects and more difficult defect repair resulting from diabetic bone disease (DBD). Melatonin (MT), which is known for its potent antioxidant properties, has been shown to stimulate both osteogenesis and angiogenesis. METHODS: MT was formulated into MT@PLGA nanoparticles (NPs), mixed with sodium alginate (SA) hydrogel, and contained within a 3D printing polycaprolactone/β-Tricalcium phosphate (PCL/β-TCP) scaffold...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38510655/tumor-integrin-targeted-theranostic-iron-oxide-nanoparticles-for-delivery-of-caffeic-acid-phenethyl-ester-preparation-characterization-and-anti-myeloma-activities
#17
JOURNAL ARTICLE
Barkley Smith, Yuancheng Li, Travis Fields, Michael Tucker, Anna Staskiewicz, Erica Wong, Handong Ma, Hui Mao, Xinyu Wang
Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells preferentially in the bone marrow. Currently, emerging chemotherapy drugs with improved biosafety profiles, such as immunomodulatory agents and protease inhibitors, have been used in clinics to treat MM in both initial therapy or maintenance therapy post autologous hematopoietic stem cell transplantation (ASCT). We previously discovered that caffeic acid phenethyl ester (CAPE), a water-insoluble natural compound, inhibited the growth of MM cells by inducing oxidative stress...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38508568/a-review-on-l-methioninase-in-cancer-therapy-precision-targeting-advancements-and-diverse-applications-for-a-promising-future
#18
REVIEW
Bhumi M Javia, Megha S Gadhvi, Suhas J Vyas, Anjana Ghelani, Nengah Wirajana, Dushyant R Dudhagara
Cancer remains a global health challenge, demanding novel therapeutic options due to the debilitating side effects of conventional treatments on healthy tissues. The review highlights the potential of L-methioninase, a pyridoxal-5-phosphate (PLP)-dependent enzyme, as a promising avenue in alternative cancer therapy. L-methioninase offers a unique advantage, its ability to selectively target and inhibit the growth of cancer cells without harming healthy cells. This selectivity arises because tumor cells lack an essential enzyme called methionine synthase, which healthy cells use to make the vital amino acid L-methionine...
March 18, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38508526/anti-inflammatory-mechanisms-of-neutrophil-membrane-coated-nanoparticles-without-drug-loading
#19
JOURNAL ARTICLE
Qing Zhang, Chengyi Hu, Jinwei Feng, Hongyan Long, Ying Wang, Pan Wang, Chenglu Hu, Yuqin Yue, Chengyuan Zhang, Zhirui Liu, Xing Zhou
Neutrophil membrane-coated nanoparticles (NM-NPs) are nanomedicines with traits of mimicking the surface properties and functions of neutrophils, which are the most abundant type of white blood cells in the human body. NM-NPs have been widely used as targeted drug delivery systems for various inflammatory diseases, but their intrinsic effects on inflammation are not fully characterized yet. This study found that NM-NPs could modulate inflammation by multiple mechanisms without drug loading. NM-NPs could inhibit the recruitment of neutrophils and macrophages to the inflamed site by capturing chemokines and blocking their adhesion to inflamed endothelial cells...
March 18, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38508524/multifactorial-drug-carrier-system-bringing-both-chemical-and-physical-therapeutics-to-the-treatment-of-tumor-heterogeneity
#20
JOURNAL ARTICLE
Eun-Jeong Nam, Inyoung Cho, Hyeji Park, Seung R Paik
Tumor heterogeneity and drug resistance have been invincible features of cancer for its complete cure. Despite the advent of immunotherapy, the expansion and diversification of cancer cells evolved even in the absence or presence of drug treatment discourage additional therapeutic interventions. For the eradication of cancer cells, therefore, an 'all-at-once' strategy is required, which exploits both target-selective chemotherapy and non-selective physicotherapy. Multifactorial microcapsules comprising gold nanoparticles (AuNPs) and a self-assembly protein of α-synuclein (αS) were fabricated, in which hydrophobic and hydrophilic drugs could be separately encapsulated by employing lipid-based inverted micelles (IMs)...
March 18, 2024: Journal of Controlled Release
keyword
keyword
114848
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.