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polymeric nanoparticles

Kai-Li Mao, Zi-Liang Fan, Jian-Dong Yuan, Pian-Pian Chen, Jing-Jing Yang, Jie Xu, De-Li ZhuGe, Bing-Hui Jin, Qun-Yan Zhu, Bi-Xin Shen, Yasin Sohawon, Ying-Zheng Zhao, He-Lin Xu
A poor percutaneous penetration capability for most topical anti-inflammatory drugs is one of the main causes compromising their therapeutic effects on psoriatic skin. Even though curcumin has shown a remarkable efficacy in the treatment of psoriasis, its effective penetration through the stratum corneum is still a major challenge during transdermal delivery. The aim of our study was to design skin-permeating nanoparticles (NPs) to facilitate delivery of curcumin to the deeper layers of the skin. A novel amphiphilic polymer, RRR-α-tocopheryl succinate-grafted-ε-polylysine conjugate (VES-g-ε-PLL) was synthesized and self-assembled into polymeric nanoparticles...
October 10, 2017: Colloids and Surfaces. B, Biointerfaces
Charalambos Kaittanis, Alexander Bolaender, Barney Yoo, Nilesh Shah, Ouathek Ouerfelli, Jan Grimm
ional approaches based on clinical modular nanoplatforms are needed, in order to treat solid cancers according to their discrete molecular features. In the present study, we show that the clinical nanopharmaceutical Ferumoxytol, which consists of a glucose-based coat surrounding an iron oxide core, could identify molecular characteristics of prostate cancer, corresponding to unique phases of the disease continuum. By affixing a targeting probe for the prostate-specific membrane antigen on its surface, the nanopharmaceutical was able to assess the functional state of the androgen receptor pathway via MRI, guiding therapy and delivering it with the same clinical nanoparticle...
October 16, 2017: Nano Letters
J M Castañeda-Gill, A P Ranjan, J K Vishwanatha
Glioblastoma (GBM) is an aggressive, grade IV brain tumor that develops from astrocytes located within the cerebrum, resulting in poor prognosis and survival rates following an accepted treatment regimen of surgery, radiation, and temozolomide. Thus, development of new therapeutics is necessary. During the last two decades, methylene blue (MB) has received increased attention as a potential neurotherapeutic due to its duality in brain cancers and neurodegenerative diseases. While MB is capable of easily permeating the blood-brain barrier, its therapeutic concentrations in GBM are known to induce off-target cytotoxicity and thus, another mode of drug delivery must be considered...
August 2017: Journal of Nanomedicine & Nanotechnology
Urvashi Aggarwal, Amit Kumar Goyal, Goutam Rath
Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer including chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from treatment and improve quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery...
October 9, 2017: Current Cancer Drug Targets
Sundeep Chaurasia, Ravi R Patel, Prasad Vure, Brahmeshwar Mishra
To improve the bioavailability and anticancer potential of naringenin (NRG) by developing a drug-loaded polymeric nano-delivery system. NRG-loaded eudragit E100 nanoparticle (NRG-EE100-NPs) system was developed, and physicochemically characterized. In vivo pharmacokinetic and in vitro cytotoxicity ability of the NRG-EE100-NPs was investigated. In vivo anticancer activity was evaluated in murine BALB/c mice-bearing colorectal tumor. The NRG-EE100-NPs had an optimum mean particle size (430.42±5.78nm), polydispersity index (0...
October 12, 2017: Journal of Pharmaceutical Sciences
Yangyang Yang, Jun Hou, Peifang Wang, Chao Wang, Lingzhan Miao, Yanhui Ao, Xun Wang, Bowen Lv, Guoxiang You, Zhilin Liu, Yongxu Shao
The behaviors of nanoparticles rely on the aqueous condition such as natural organic matter (NOM). Therefore the presence of NOM would influence the interaction of nanoparticles with other substances possibly. Here, microcystin-LR (MC-LR) adsorption on iron oxide nanoparticles (IONPs) was studied in an aqueous solution with different types of NOM, including extracellular polymeric substances (EPS) from cyanobacteria and alginic acid sodium salt (AASS) from brown algae. Results revealed that EPS played an important role in stabilizing IONPs and in the toxin adsorption efficiency...
October 12, 2017: Ecotoxicology and Environmental Safety
Chuan-Shu He, Pan-Pan He, Hou-Yun Yang, Ling-Li Li, Yue Lin, Yang Mu, Han-Qing Yu
The study aimed at evaluating the influence of nano zero-valent iron (nZVI) on the activity of anaerobic granular sludge (AGS) from both macroscopic and microcosmic aspects using different methodologies. The tolerance response of AGS to nZVI was firstly investigated using short-term and long-term experiments, and also compared with anaerobic flocs. The Fe fate and distribution, the change of contents/structure of extracellular polymeric substances (EPS), and the variation of microbial community in the AGS after exposure to nZVI were further explored...
October 1, 2017: Water Research
Bing-Jian Yao, Luo-Gang Ding, Fei Li, Jiang-Tao Li, Qi-Juan Fu, Yujie Ban, Ang Guo, Yu-Bin Dong
CO2 capture and transformation are of great importance to make cuts in greenhouse gas emissions. Nano metal-organic frameworks (NMOFs) could serve as the ideal fillers for polymer-membranes owing to their structural diversity and regulable micro-environment of the nanocage. Herein, a bifunctional robust and chemically cross-linked NMOF-based membrane was successfully constructed by the post-synthetic polymerization of imidazolium-based ionic liquid decorated UiO-66 type nanoparticles (NPs) and isocyanate-terminated polyurethane oligomer under mild condition...
October 13, 2017: ACS Applied Materials & Interfaces
Kesong Tian, Ruifei Li, Haiyan Wang, Yan Chen, Wanchun Guo, Yaqi Wang, Zhaopeng Xu
Functional polymer-grafting silica nanoparticles hold great promise in diverse applications such as molecule recognition, drug delivery, and heterogeneous catalysis due to high density and uniform distribution of functional groups and their tunable spatial distance. However, conventional grafting methods from monomers mainly consist of one or more extra surface modification steps and a subsequent surface polymerization step. A monomer protonation-dependent surface polymerization strategy is proposed to achieve one-step uniform surface grafting of cross-linked poly(4-vinylpyridine) (P4VP) onto core-shell Fe3 O4 @SiO2 nanostructures...
October 13, 2017: Macromolecular Rapid Communications
Che-Ming Jack Hu, Wei-Shan Chang, Zih-Syun Fang, You-Ting Chen, Wen-Lin Wang, Hsiao-Han Tsai, Ling-Ling Chueh, Tomomi Takano, Tsutomu Hohdatsu, Hui-Wen Chen
Feline infectious peritonitis (FIP), caused by a mutated feline coronavirus, is one of the most serious and fatal viral diseases in cats. The disease remains incurable, and there is no effective vaccine available. In light of the pathogenic mechanism of feline coronavirus that relies on endosomal acidification for cytoplasmic entry, a novel vacuolar ATPase blocker, diphyllin, and its nanoformulation are herein investigated for their antiviral activity against the type II feline infectious peritonitis virus (FIPV)...
October 12, 2017: Scientific Reports
Yingge Shi, Dazhuang Xu, Meiying Liu, Lihua Fu, Qing Wan, Liucheng Mao, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Fluorescent organic nanoparticles (FONs) have been regarded as the promising candidates for biomedical applications owing to their well adjustment of chemical structure and optical properties and good biological properties. However, the preparation of FONs from the natural derived polymers has been rarely reported thus far. In current work, we reported a novel strategy for preparation of FONs based on the self-polymerization of starch-dopamine conjugates and polyethyleneimine in rather mild experimental conditions, including air atmosphere, aqueous solution, absent catalysts and at room temperature...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Mariana Duarte, Prabal Subedi, Ecevit Yilmaz, Katrin Marcus, Thomas Laurell, Simon Ekström
Phosphorylation is a protein post-translational modification (PTM) that plays an important role in cell signaling, cell differentiation, and metabolism. The hyper phosphorylated forms of certain proteins have been appointed as biomarkers for neurodegenerative diseases, and phosphorylation-related mutations are important for detecting cancer pathways. Due to the low abundance of phosphorylated proteins in biological fluids, sample enrichment is beneficial prior to detection. Thus, a need to find new strategies for enriching phosphopeptides has emerged...
October 12, 2017: Journal of Molecular Recognition: JMR
Sergio G Hernandez-Leon, Jose Andre-I Sarabia-Sainz, Gabriela Ramos-Clamont Montfort, Ana M Guzman-Partida, Maria Del Refugio Robles-Burgueño, Luz Vazquez-Moreno
Silica nanoparticles were functionalized with immobilized molecular bait, Cibacron Blue, and a porous polymeric bis-acrylamide shell. These nanoparticles represent a new alternative to capture low molecular weight (LMW) proteins/peptides, that might be potential biomarkers. Functionalized core-shell silica nanoparticles (FCSNP) presented a size distribution of 243.9 ± 11.6 nm and an estimated surface charge of -38.1 ± 0.9 mV. The successful attachment of compounds at every stage of synthesis was evidenced by ATR-FTIR...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Priya S R Naidu, Marck Norret, Nicole M Smith, Sarah A Dunlop, Nicolas L Taylor, Melinda Fitzgerald, K Swaminathan Iyer
Composition of the protein corona formed on poly(ethylene glycol)-functionalised (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for 'stealth' functionality, we demonstrate preferential enrichment of specific serum proteins of varied biological functions in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona...
October 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Kate L Thompson, Natacha Cinotti, Elizabeth R Jones, Charlotte J Mable, Patrick William Fowler, Steven P Armes
Sterically-stabilized diblock copolymer nanoparticles with an intensity-average diameter of 25 nm are prepared in the form of a concentrated aqueous dispersion using polymerization-induced self-assembly (PISA). Addition of n-dodecane followed by high-shear homogenization produces n-dodecane-in-water Pickering macroemulsions of 22-46 µm diameter. If the nanoparticles are present in sufficient excess, subsequent processing using a high-pressure microfluidizer leads to formation of Pickering nanoemulsions with a mean droplet diameter below 200 nm...
October 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Brigida Silvestri, Giuseppe Vitiello, Giuseppina Luciani, Vincenzo Calcagno, Aniello Costantini, Maria Gallo, Silvia Parisi, Simona Paladino, Mariagrazia Iacomino, Gerardino D'Errico, Maria Federica Caso, Alessandro Pezzella, Marco d'Ischia
We disclose herein the first example of stable monodispersed hybrid nanoparticles (termed MelaSil-NPs) made up of eumelanin biopolymer intimately integrated into a silica nanoscaffold matrix and endowed with high antioxidant and cytoprotective effects associated with a specific subcellular localization. MelaSil-NPs have been fabricated by an optimized sol-gel methodology involving ammonia-induced oxidative polymerization of a covalent conjugate of the eumelanin building block 5,6-dihydroxyindole-2-carboxylic acid (DHICA) with 3-aminopropyltriethoxysilanes (APTS)...
October 12, 2017: ACS Applied Materials & Interfaces
Brian R Pauw, Claudia Kästner, Andreas F Thünemann
This paper presents the first worldwide inter-laboratory comparison of small-angle X-ray scattering (SAXS) for nanoparticle sizing. The measurands in this comparison are the mean particle radius, the width of the size distribution and the particle concentration. The investigated sample consists of dispersed silver nanoparticles, surrounded by a stabilizing polymeric shell of poly(acrylic acid). The silver cores dominate the X-ray scattering pattern, leading to the determination of their radius size distribution using (i) the generalized indirect Fourier transformation method, (ii) classical model fitting using SASfit and (iii) a Monte Carlo fitting approach using McSAS...
October 1, 2017: Journal of Applied Crystallography
Herman Palacio, Felipe Otálvaro, Luis F Giraldo, Gilles Ponchel, Freimar Segura-Sánchez
Drug delivery represents one of the most important research fields within the pharmaceutical industry. Different strategies are reported every day in a dynamic search for carriers with the ability to transport drugs across the body, avoiding or decreasing toxic issues and improving therapeutic activity. One of the most interesting strategies currently under research is the development of drug delivery systems sensitive to different stimuli, due to the high potential attributed to the selective delivery of the payload...
October 12, 2017: Chemical & Pharmaceutical Bulletin
Zhiliang Chen, Börje Sellergren, Xiantao Shen
In this work, we developed an efficient "molecularly imprinted polymer microzymes and inorganic magnetic nanozymes" synergistic catalysis strategy for the formation of disulfide bonds in peptides. The polymeric microzymes showed excellent selectivity toward the template peptide as well as the main reactant (linear peptide), and the Fe3O4 magnetic nanoparticle (MNP) nanozymes inhibited the intermolecular reaction during the formation of disulfide bonds in peptides. As a result, the integration of the two different artificial enzymes in one process facilitates the intramolecular cyclization in high product yields (59...
2017: Frontiers in Chemistry
Tian-Xu Zhang, Guan-Yin Zhu, Bo-Yao Lu, Chao-Liang Zhang, Qiang Peng
AIM: A comprehensive understanding of nanoparticle (NP)-protein interaction (protein corona formation) is required. So far, many factors influencing this interaction have been investigated, like size and ζ potential. However, NPs exposure concentration has always been ignored. Herein, we aim to disclose the correlation of NPs exposure concentration with protein adsorption. MATERIALS & METHODS: Four polymeric NPs systems possessing similar sizes (230 ± 20 nm) but varied ζ potentials (-30 ∼ +40 mv) were prepared...
October 10, 2017: Nanomedicine
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