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https://www.readbyqxmd.com/read/28335282/inverter-circuits-using-zno-nanoparticle-based-thin-film-transistors-for-flexible-electronic-applications
#1
Fábio F Vidor, Thorsten Meyers, Ulrich Hilleringmann
Innovative systems exploring the flexibility and the transparency of modern semiconducting materials are being widely researched by the scientific community and by several companies. For a low-cost production and large surface area applications, thin-film transistors (TFTs) are the key elements driving the system currents. In order to maintain a cost efficient integration process, solution based materials are used as they show an outstanding tradeoff between cost and system complexity. In this paper, we discuss the integration process of ZnO nanoparticle TFTs using a high-k resin as gate dielectric...
August 23, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28331311/a-potential-in-situ-gel-formulation-loaded-with-novel-fabricated-poly-lactide-co-glycolide-nanoparticles-for-enhancing-and-sustaining-the-ophthalmic-delivery-of-ketoconazole
#2
Tarek Abdelnapy Ahmed, Bader M Aljaeid
Oral ketoconazole therapy is commonly associated with serious hepatotoxicity. Improving ocular drug delivery could be sufficient to treat eye fungal infections. The purpose of this study was to develop optimized ketoconazole poly(lactide-co-glycolide) nanoparticles (NPs) with subsequent loading into in situ gel (ISG) formulation for ophthalmic drug delivery. Three formulation factors were optimized for their effect on particle size (Y1) and entrapment efficiency (Y2) utilizing central composite experimental design...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28327712/structural-transformation-of-vesicles-formed-by-a-polystyrene-b-poly-acrylic-acid-polystyrene-b-poly-4-vinyl-pyridine-mixture-from-symmetric-to-asymmetric-membranes
#3
Zhen Geng, Yuanyuan Han, Wei Jiang
Asymmetric vesicles with different inner and outer corona compositions are applicable in microreactors, drug delivery, and biomimics because of their unique functions in membrane permeability and protein localization. In this study, we develop a novel approach to construct asymmetric vesicles and demonstrate the first structural transformation of polymeric vesicles from symmetric to asymmetric membranes. Experimental results and Monte Carlo simulation results clearly reveal that increased intercorona repulsion and enhanced hydrophobic chain mobility are essential to realize this transformation...
March 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28327584/hybrid-core-shell-hycos-nanoparticles-produced-by-complex-coacervation-for-multimodal-applications
#4
D Vecchione, A M Grimaldi, E Forte, Paolo Bevilacqua, P A Netti, E Torino
Multimodal imaging probes can provide diagnostic information combining different imaging modalities. Nanoparticles (NPs) can contain two or more imaging tracers that allow several diagnostic techniques to be used simultaneously. In this work, a complex coacervation process to produce core-shell completely biocompatible polymeric nanoparticles (HyCoS) for multimodal imaging applications is described. Innovations on the traditional coacervation process are found in the control of the reaction temperature, allowing a speeding up of the reaction itself, and the production of a double-crosslinked system to improve the stability of the nanostructures in the presence of a clinically relevant contrast agent for MRI (Gd-DTPA)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28326230/methods-for-preparing-polymer-decorated-single-exchange-biased-magnetic-nanoparticles-for-application-in-flexible-polymer-based-films
#5
Laurence Ourry, Delphine Toulemon, Souad Ammar, Fayna Mammeri
Background: Magnetic nanoparticles (NPs) must not only be well-defined in composition, shape and size to exhibit the desired properties (e.g., exchange-bias for thermal stability of the magnetization) but also judiciously functionalized to ensure their stability in air and their compatibility with a polymer matrix, in order to avoid aggregation which may seriously affect their physical properties. Dipolar interactions between NPs too close to each other favour a collective magnetic glass state with lower magnetization and coercivity because of inhomogeneous and frustrated macrospin cluster freezing...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28323414/design-of-insulin-loaded-nanoparticles-enabled-by-multistep-control-of-nanoprecipitation-and-zinc-chelation
#6
Sunandini Chopra, Nicolas Bertrand, Jong-Min Lim, Amy Wang, Omid C Farokhzad, Rohit Karnik
Nanoparticle (NP) carriers provide new opportunities for controlled delivery of drugs, and have potential to address challenges such as effective oral delivery of insulin. However, due to the difficulty of efficiently loading insulin and other proteins inside polymeric NPs, their use has been mostly restricted to the encapsulation of small molecules. To better understand the processes involved in encapsulation of proteins in NPs, we study how buffer conditions, ionic chelation, and preparation methods influence insulin loading in poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-PEG) NPs...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28323297/excimers-from-stable-and-persistent-supramolecular-radical-pairs-in-red-nir-emitting-organic-nanoparticles-and-polymeric-films
#7
Davide Blasi, Domna M Nikolaidou, Francesca Terenziani, Imma Ratera, Jaume Veciana
In this work, the luminescence properties of new materials based on open-shell molecular systems are studied. In particular, we prepared polymeric films and organic nanoparticles (ONPs) doped with triphenylmethyl radical molecules. ONPs exhibit a uniform size distribution, spherical morphology and high colloidal stability. The emission spectrum of low-doped ONP suspensions and low-doped films is very similar to the emission spectrum of TTM in solution, while the luminescence lifetime and the luminescence quantum yield (LQY) are highly increased...
March 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28323099/nanohydrogel-with-n-n-bis-acryloyl-cystine-crosslinker-for-high-drug-loading
#8
Marcin Mackiewicz, Jan Romanski, Ewa Drozd, Beata Gruber-Bzura, Piotr Fiedor, Zbigniew Stojek, Marcin Karbarz
Substantially improved hydrogel particles based on poly(N-isopropylacrylamide) (pNIPA) have been obtained. First, as a result of replacing commercially available N,N'-bis(acryloyl)cystamine (BAC), the crosslinker, with acryloyl derivative of cystine containing a carboxylic group (BISS), the hydrogel particles acquired improved stability vs. ionic strength and allowed further chemical modification of the chains, including the attachment of drug molecules. Next, a redox-initiated aqueous precipitation polymerization via the semi-batch method was used...
March 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28323096/nanoparticles-as-safe-and-effective-delivery-systems-of-antifungal-agents-achievements-and-challenges
#9
REVIEW
Ghareb M Soliman
Invasive fungal infections are becoming a major health concern in several groups of patients leading to severe morbidity and mortality. Moreover, cutaneous fungal infections are a major cause of visits to outpatient dermatology clinics. Despite the availability of several effective agents in the antifungal drug arena, their therapeutic outcome is less than optimal due to limitations related to drug physicochemical properties and toxicity. For instance, poor aqueous solubility limits the formulation options and efficacy of several azole antifungal drugs while toxicity limits the benefits of many other drugs...
March 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28322141/lessons-learned-from-gemcitabine-impact-of-therapeutic-carrier-systems-and-gemcitabine-s-drug-conjugates-on-cancer-therapy
#10
REVIEW
Sathish Dyawanapelly, Animesh Kumar, Manish K Chourasia
Currently, drug delivery systems have a high impact in cancer therapy and are receiving more attention than conventional cancer treatment modalities. Compared with current cancer therapies, gemcitabine (2', 2'-difluoro-2'-deoxycytidine) has been proven to be an effective chemotherapeutic agent against pancreatic, colon, bladder, breast, ovarian, non-small-cell lung, and head and neck cancers in combination with other anticancer agents. To improve the safety and efficacy of cytotoxic drugs, several drug delivery systems have been explored...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/28322116/expanding-the-potential-of-mri-contrast-agents-through-multifunctional-polymeric-nanocarriers
#11
Ioana Craciun, Gesine Gunkel-Grabole, Andrea Belluati, Cornelia G Palivan, Wolfgang Meier
MRI is a sought-after, noninvasive tool in medical diagnostics, yet the direct application of contrast agents to tissue suffers from several drawbacks. Hosting the contrast agents in polymeric nanocarriers can solve many of these issues while creating additional benefit through exploitation of the intrinsic characteristics of the polymeric carriers. In this report, the versatility is highlighted with recent examples of dendritic and hyperbranched polymers, polymer nanoparticles and micelles, and polymersomes as multifunctional bioresponsive nanocarriers for MRI contrast agents...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322107/surface-modulation-of-polymeric-nanocarriers-enhances-the-stability-and-delivery-of-proteins-and-small-molecules
#12
Zohreh Amoozgar, Michael S Goldberg
AIM: We aimed to enhance the stability and therapeutic efficiency of protein-based therapeutic formulations. MATERIALS & METHODS: Proteins were immobilized on the surface of nanoparticles (NPs) to improve both protein stability and protein function, especially enzymatic activity. The modularity of the platform was demonstrated by coating proteins of varied molecular weights and functionalities on the surface of poly(lactic-co-glycolic acid)-based NPs. RESULTS: Coating proteins to the particle surface greatly enhanced the stability of the NPs, preventing particle aggregation and improving enzymatic potency, including in vivo...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28320528/superfine-powdered-activated-carbon-incorporated-into-electrospun-polystyrene-fibers-preserve-adsorption-capacity
#13
Onur G Apul, Natalia Hoogesteijn von Reitzenstein, Jared Schoepf, David Ladner, Kiril D Hristovski, Paul Westerhoff
A composite material consisted of superfine powdered activated carbon (SPAC) and fibrous polystyrene (PS) was fabricated for the first time by electrospinning. SPAC is produced by pulverizing powdered activated carbon. The diameter of SPAC (100-400nm) is more than one hundred times smaller than conventional powdered activated carbon, but it maintains the internal pore structure based on organic micropollutant adsorption isotherms and specific surface area measurements. Co-spinning SPAC into PS fibers increased specific surface area from 6m(2)/g to 43m(2)/g...
March 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28317931/recruitment-of-bone-marrow-cd11b-gr-1-cells-by-polymeric-nanoparticles-for-antigen-cross-presentation
#14
Ya-Wun Yang, Wen-Hui Luo
The objective of this study was to investigate the function of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) on the activation of antigen-specific CD8(+) T cell responses via the CD11b(+)Gr(-)1(+) myeloid subpopulations in murine bone marrow (BM). PLGA NPs containing ovalbumin (OVA) were fabricated by the double-emulsion method. The CD11b(+)Gr-1(low)Ly-6C(high) and CD11b(+)Gr-1(high)Ly-6C(low) subsets from mice bone marrow were sorted and treated with the PLGA/OVA NPs, followed by co-culture with the carboxyfluorescein succinimidyl ester (CFSE)-labelled OT-I CD8(+) cells...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317839/polymeric-mechanical-amplifiers-of-immune-cytokine-mediated-apoptosis
#15
Michael J Mitchell, Jamie Webster, Amanda Chung, Pedro P G Guimarães, Omar F Khan, Robert Langer
Physical forces affect tumour growth, progression and metastasis. Here, we develop polymeric mechanical amplifiers that exploit in vitro and in vivo physical forces to increase immune cytokine-mediated tumour cell apoptosis. Mechanical amplifiers, consisting of biodegradable polymeric particles tethered to the tumour cell surface via polyethylene glycol linkers, increase the apoptotic effect of an immune cytokine on tumour cells under fluid shear exposure by as much as 50% compared with treatment under static conditions...
March 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28315584/high-density-polystyrene-grafted-silver-nanoparticles-and-their-use-in-the-preparation-of-nanocomposites-with-antibacterial-properties
#16
Piotr Krystosiak, Waldemar Tomaszewski, Elżbieta Megiel
The achievement of uniform nanoparticles distribution in polymer matrix is still a major challenge in the design and fabrication of polymer nanocomposites with desired properties. In this paper we propose a novel approach for the preparation of homogeneous polystyrene/silver nanocomposites utilizing Nitroxide Mediated Radical Polymerization (NMRP). In the first step of the developed procedure, the polystyrene grafted silver nanoparticles (Ag@PS) with well-defined core-shell structure and exceptionally high grafting density (from 2 chains/nm(2) to 5...
March 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28304158/near-infrared-light-responsive-semiconductor-polymer-composite-hydrogels-toward-spatial-temporal-controlled-release-via-photothermal-sponge-effect
#17
Yingjie Wu, Kai Wang, Shuo Huang, Cangjie Yang, Mingfeng Wang
Near-infrared (NIR) light-responsive hydrogels are important for biomedical applications such as remotely controlled release, but the NIR agents previously used have been largely limited to heavy-metal inorganic materials such as gold nanoparticles. In this article, we report a new type of NIR photothermal responsive hydrogels, which could undergo structural changes in response to NIR light for biomedical applications in drug delivery and controlled release. The hydrogels synthesized by integrating a narrow bandgap semiconductor polymer poly(diketopyrrolopyrrole-alt-3,4-ethylenedioxythiophene) (PDPPEDOT) with polymerization of N-isopropylacrylamide (NIPAM) show rapid and reversible mechanical shrinkage upon NIR light irradiation and can serve as carriers for anticancer drug loading and spatial/temporal control of drug release...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28300658/effect-of-particle-size-on-the-biodistribution-toxicity-and-efficacy-of-drug-loaded-polymeric-nanoparticles-in-chemoradiotherapy
#18
Joseph M Caster, Stephanie K Yu, Artish N Patel, Nicole J Newman, Zachary J Lee, Samuel B Warner, Kyle T Wagner, Kyle C Roche, Xi Tian, Yuanzeng Min, Andrew Z Wang
Nanoparticle (NP) therapeutics can improve the therapeutic index of chemoradiotherapy (CRT). However, the effect of NP physical properties, such particle size, on CRT is unknown. To address this, we examined the effects of NP size on biodistribution, efficacy and toxicity in CRT. PEG-PLGA NPs (50, 100, 150nm mean diameters) encapsulating wotrmannin (wtmn) or KU50019 were formulated. These NP formulations were potent radiosensitizers in vitro in HT29, SW480, and lovo rectal cancer lines. In vivo, the smallest particles avoided hepatic and splenic accumulation while more homogeneously penetrating tumor xenografts than larger particles...
March 11, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28299903/multifunctional-nanoparticle-composites-progress-in-the-use-of-soft-and-hard-nanoparticles-for-drug-delivery-and-imaging
#19
REVIEW
Ajmeeta Sangtani, Okhil K Nag, Lauren D Field, Joyce C Breger, James B Delehanty
With continued advancements in nanoparticle (NP) synthesis and in the interfacing of NPs with biological systems has come the exponential growth in the use of NPs for therapeutic drug delivery and imaging applications. In recent years, the advent of NP multifunctionality-the ability to perform multiple, disparate functions on a single NP platform-has garnered much excitement for the potential realization of highly functional NP-mediated drug delivery for use in the clinical setting. This Overview will survey the current state of the art (reports published within the last 5 years) of multifunctional NPs for therapeutic drug delivery, imaging or a combination thereof...
March 16, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28299757/nanoparticle-delivered-chemotherapy-old-drugs-in-new-packages
#20
REVIEW
Michael S Lee, E Claire Dees, Andrew Z Wang
Cytotoxic chemotherapies have a narrow therapeutic window, with high peaks and troughs of plasma concentration. Novel nanoparticle formulations of cytotoxic chemotherapy drugs can enhance pharmacokinetic characteristics and facilitate passive targeting of drugs to tumors via the enhanced permeability and retention effect, thus mitigating toxicity. Nanoparticle vehicles currently in clinical use or undergoing clinical investigation for anticancer therapies include liposomes, polymeric micelles, protein-drug nanoparticles, and dendrimers...
March 15, 2017: Oncology (Williston Park, NY)
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