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polymeric nanoparticles

Qingfu Ban, Jie Kong, Yinglai Hou, Jianxin Chen, Wen Sun, Xiaofei Zhang, Si Wu
We demonstrated an unconventional polymerization route to synthesize hydrophilic fluorescent organic nanoparticles (FONs) for multicolor cellular bioimaging in this contribution. Actually, it benefits from our unexpected discovery of a rapid polymerization reaction between 1, 6-hexanediol dipropiolate and 2, 4, 6-triazide-1, 3, 5-triazine under the catalysis of N, N, N', N", N"-pentamethyldiethylenetriamine (PMDETA). Interestingly, the 2, 4, 6-triazide-1, 3, 5-triazine and PMDETA system can also induce rapid free radical polymerization at room temperature...
April 18, 2018: Chemistry, An Asian Journal
Mohammed Al-Qahtani, Yousif Al Malki, Hadeel Mutwali, Edward Helal-Neto, Ralph Santos-Oliveira
BACKGROUND AND OBJECTIVE: The future of medicine relies on the capability to forecast the future and in the development of new drugs. The same rationale is applied to radiopharmacy. In this direction the development of nano-radiopharmaceuticals represents the most effective glance of the future. METHODS: In this manuscript we developed an efficient, rapid and direct methodology to label ultra-small polymeric nanoparticle (10 to 12 nm) and regular polymeric nanoparticles (200 to 210 nm), both obtained by double emulsion technique, with Ga-68 in order to promote the development of PET-nanoradiopharmaceuticals...
April 17, 2018: Current Radiopharmaceuticals
Yongtao Tan, Ying Liu, Zhenghua Tang, Zhe Wang, Lingbin Kong, Long Kang, Zhen Liu, Fen Ran
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 18, 2018: Scientific Reports
Jianhong Liao, Haoran Zheng, Rui Hu, Jun Cao, Xuan Wei, Dan Li, Hua Zheng, Yihua Yin
In this study, a series of amphiphilic polymeric prodrugs (Azido-functionalized hyaluronan-triazole-imine-doxorubicin, HAimine-DOX) were designed and synthesized by the "Click" reaction with a remarkable grafting ratio of DOX. Nanoparticles with a core-shell structure can be obtained by self-assembling in aqueous media, which exhibited a particle size of 137-170 nm. Moreover, the HA-imine-DOX nanoparticles exhibited good stability in vitro, and the drug release was obviously mediated by the pH gradient...
March 1, 2018: Journal of Biomedical Nanotechnology
Tejal Rawal, Neha Mishra, Abhishek Jha, Apurva Bhatt, Rajeev K Tyagi, Shital Panchal, Shital Butani
The elevated blood levels of cholesterol and low-density lipoproteins result in hyperlipidemia. The available expensive prophylactic treatments are kindred with severe side effects. Therefore, we fabricated the polymeric nanoparticles of gamma-oryzanol to achieving the improved efficacy of drug. The nanoparticles were prepared by ionic gelation method and optimized using 23 full factorial design taking drug/polymer ratio (X1 ), polymer/cross linking agent ratio (X2 ), and stirring speed (X3 ) as independent variables...
April 16, 2018: AAPS PharmSciTech
S Ichikawa, N Shimokawa, M Takagi, Y Kitayama, T Takeuchi
Size-dependent uptake behaviors of electrically neutral amphipathic polymeric nanoparticles in cell-sized liposomes and living cells were investigated. Kinetic analyses and the particle size distribution suggested a size-dependent penetration mechanism (size threshold: 3.1 nm). The definite size-dependent uptake provides a new insight into the interactions between nanomaterials and living cells.
April 17, 2018: Chemical Communications: Chem Comm
Julius Mueller, Johanna Simon, Philipp Rohne, Claudia Koch-Brandt, Volker Mailaender, Svenja Morsbach, Katharina Landfester
The use of nanocarriers as drug delivery vehicles brings them into contact with blood plasma proteins. Polymeric nanocarriers require some sort of surfactant to ensure colloidal stability. Formation of the protein corona is therefore not only determined by the intrinsic properties of the nanocarrier itself, but also by the accompanying surfactant. Although it is well known that surfactants have an impact on protein structure, only few studies were conducted on the specific effect of surfactants on the composition of protein corona of nanocarriers...
April 16, 2018: Biomacromolecules
Hui-Juan Li, Peng-Yun Li, Li-Ying Li, Abdul Haleem, Wei-Dong He
Narrowly distributed poly(l-lysine- b - N -isopropylacrylamide) (PLL- b -PNIPAM) was prepared through ring-opening polymerization of ε-benzyloxycarbonyl-l-lysine N -carboxy-α-amino anhydride and atom transfer radical polymerization of NIPAM, followed with the removal of ε-benzyloxycarbonyl group. Then gold nanoparticles (AuNPs) grafted with PLL- b -PNIPAM (PNIPAM-PLL-AuNPs) were obtained by the reduction of chloroauric acid with sodium citrate in the presence of PLL- b -PNIPAM...
April 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Amit Jain, Jun Kim, Oluwaseye M Owoseni, Cierra Weathers, Daniel Cana, Kuichang Zuo, William Shane Walker, Qilin Li, Rafael Verduzco
Membrane Capacitive Deionization (MCDI) is a low-cost technology for desalination. Typically, MCDI electrodes are fabricated using a slurry of nanoparticles in an organic solvent along with polyvinylidene fluoride (PVDF) polymeric binder. Recent studies of the environmental impact of CDI have pointed to the use organic solvents in the fabrication of CDI electrodes as key contributors to the overall environmental impact of the technology. Here, we report a scalable, aqueous processing approach to prepare MCDI electrodes using water-soluble polymer polyvinyl alcohol (PVA) as a binder and ion-exchange polymer...
April 16, 2018: Environmental Science & Technology
Ya-Ru Zhang, Run Lin, Hong-Jun Li, Wei-Ling He, Jin-Zhi Du, Jun Wang
Nanoparticles (NPs) have emerged as an effective means to deliver therapeutic drugs for cancer treatment, as they can preferentially accumulate at tumor site through the enhanced permeability and retention effect. Various forms of NPs including liposomes, polymeric micelles, and inorganic particles have been used for therapeutic applications. However, the therapeutic benefits of nanomedicines are suboptimal. Although many possible reasons may account for the compromised therapeutic efficacy, the inefficient tumor penetration can be a vital obstacle...
April 16, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Elena Nikolskaya, Mariya Sokol, Mariya Faustova, Olga Zhunina, Murad Mollaev, Nikita Yabbarov, Oksana Tereshchenko, Roman Popov, Eugen Severin
PURPOSE: The aim of this study was to compare the physico-chemical and biological properties of polymeric nanoparticles obtained from poly(DL-lactide-co-glycolide) (PLGA) with different ratios of monomers loaded with daunorubicin (DNR). METHODS: DNR-loaded nanoparticles (NPs) were prepared with use of modified simultaneous double-emulsion solvent evaporation/diffusion technique. NPs were characterized using dynamic light scattering, atomic force microscopy, transmission electron microscopy, scanning electron microscopy, and differential scanning calorimetry and Fourier transform infrared spectroscopy...
2018: Acta of Bioengineering and Biomechanics
Marti Z Hua, Shaolong Feng, Shuo Wang, Xiaonan Lu
We report the development of a molecularly imprinted polymers-surface-enhanced Raman spectroscopy (MIPs-SERS) method for rapid detection and quantification of a herbicide residue 2,4-dichlorophenoxyacetic acid (2,4-D) in milk. MIPs were synthesized via bulk polymerization and utilized as solid phase extraction sorbent to selectively extract and enrich 2,4-D from milk. Silver nanoparticles were synthesized to facilitate the collection of SERS spectra of the extracts. Based on the characteristic band intensity of 2,4-D (391 cm-1 ), the limit of detection was 0...
August 30, 2018: Food Chemistry
Zhenqi Jiang, Yuchen Tian, Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Juan Li, Jian Yang, Aiguo Wu
Nanoparticle-based tumor therapies are extensively studied; however, few are capable of improving patient survival time due to premature drug leakage, off target effects, and poor tissue penetration. Previously, we successfully synthesized a novel family of Y1 receptor (Y1 R) ligand modified, photoluminescent BPLP nanobubbles and nanoparticles for targeted breast cancer ultrasound imaging; however, increased accumulation could also be observed in the liver, kidney, and spleen, suggesting significant interaction of the particles with macrophages in vivo...
April 4, 2018: Biomaterials
Baoqiang Tang, Jennica L Zaro, Yan Shen, Qian Chen, Yinglan Yu, Pingping Sun, Yanqi Wang, Wei-Chiang Shen, Jiasheng Tu, Chunmeng Sun
Cell-penetrating peptides (CPPs) have become a novel drug delivery system due to their distinct advantages, including high cell transmembrane potency and ability to carry cargo molecules inside cells. However, owing to their cationic charge and non-specificity characteristics, the clinical application of CPPs is limited. In the current study, we engineered a reversibly activatable cell-penetrating peptide (RACPP), containing oligoarginine fused to a pH-sensitive masking sequence via a polyglycine linker ((HE)10 G5 R6 or HE-CPP) with ultra-pH-sensitivity...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
Adrián Jiménez-Balsa, Sandra Pinto, Emanuel Quartin, Miguel M Lino, Vitor Francisco, Lino Ferreira
We report the synthesis and characterization of phototriggerable polymeric nanoparticles (NPs) for the intracellular delivery of small molecules and proteins to modulate cell activity. For that purpose, several photocleavable linkers have been prepared providing diverse functional groups as anchoring points for biomolecules.
April 13, 2018: Bioconjugate Chemistry
Zeng Zhen, Mingfen Wen, Boxuan Yu, Gang Ye, Xiaomei Huo, Yuexiang Lu, Jing Chen
Oxidant-regulated polymerization of dopamine was exploited, for the first time, for effective surface engineering of the well-defined cylindrical pores of nuclear track-etched membranes (NTEMs) to develop novel catalytic membrane reactor. Firstly, in the presence of strong oxidant, controlled synthesis of polydopamine (PDA) with tunable particle size was achieved, allowing a homogeneous deposition to the confined pore channels of NTEMs. The PDA interfaces rich in catechol and amine groups provided enhanced hydrophilicity to promote mass transport across the membrane and abundant nucleation sites for formation and stabilization of metallic nanoparticles (NPs)...
April 13, 2018: ACS Applied Materials & Interfaces
Jaydev R Upponi, Kaushal Jerajani, Dattatri K Nagesha, Praveen Kulkarni, Srinivas Sridhar, Craig Ferris, Vladimir P Torchilin
Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro...
March 31, 2018: Biomaterials
Gregory N Smith, Laura L E Mears, Sarah E Rogers, Steven P Armes
Cationic diblock copolymer nanoparticles have been prepared in n -dodecane via polymerization-induced self-assembly (PISA). A previously reported poly(stearyl methacrylate)-poly(benzyl methacrylate) (PSMA-PBzMA) PISA formulation ( Chem. Sci. 2016, 7 , 5078-5090) was modified by statistically copolymerizing an oil-soluble cationic methacrylic monomer, (2-(methacryloyloxy)ethyl)trimethylammonium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, with either SMA or BzMA, to produce either charged shell or charged core nanoparticles...
January 28, 2018: Chemical Science
Li-Juan Feng, Jing-Jing Wang, Shu-Chang Liu, Xiao-Dong Sun, Xian-Zheng Yuan, Shu-Guang Wang
Microplastics and nanoplastics in aquatic systems have become a global concern because of their persistence and adverse consequences to ecosystems and potentially human health. Though wastewater treatment plants (WWTPs) are considered a potential source of microplastics in the environment, the role of extracellular polymeric substances (EPS) of activated sludge on the fate of nanoplastics is not clear. In this study, the role of EPS in the influence of polystyrene nanoparticles (PS-NPs) on the endogenous respiration of activated sludge was investigated for the first time...
April 5, 2018: Environmental Pollution
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