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https://www.readbyqxmd.com/read/28454020/toxicity-of-tio2-in-nanoparticle-or-bulk-form-to-freshwater-and-marine-microalgae-under-visible-light-and-uv-a-radiation
#1
M Sendra, I Moreno-Garrido, M P Yeste, J M Gatica, J Blasco
Use of titanium dioxide nanoparticles (TiO2 NPs) has become a part of our daily life and the high environmental concentrations predicted to accumulate in aquatic ecosystems are cause for concern. Although TiO2 has only limited reactivity, at the nanoscale level its physico-chemical properties and toxicity are different compared with bulk material. Phytoplankton is a key trophic level in fresh and marine ecosystems, and the toxicity provoked by these nanoparticles can affect the structure and functioning of ecosystems...
April 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28453954/local-delivery-of-chondroitinase-abc-with-or-without-stromal-cell-derived-factor-1%C3%AE-promotes-functional-repair-in-the-injured-rat-spinal-cord
#2
Malgosia M Pakulska, Charles H Tator, Molly S Shoichet
Traumatic spinal cord injury (SCI) is a devastating event for which functional recovery remains elusive. Due to the complex nature of SCI pathology, a combination treatment strategy will likely be required for success. We hypothesized that tissue and functional repair would be achieved in a rat model of impact-compression SCI by combining degradation of the glial scar, using chondroitinase ABC (ChABC), with recruitment of endogenous neural precursor cells (NPCs), using stromal cell-derived factor 1α (SDF)...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28453929/synthesis-of-lipophilic-core-shell-fe3o4-sio2-au-nanoparticles-and-polymeric-entrapment-into-nano-micelle-a-novel-nanosystem-for-in-vivo-active-targeting-and-magnetic-resonance-photoacoustic-dual-imaging
#3
Ilaria Monaco, Francesca Arena, Stefania Biffi, Erika Locatelli, Barbara Bortot, Francesca La Cava, Giada Maria Marini, Gian Maria Severini, Enzo Terreno, Mauro Comes Franchini
In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthetized to obtain a promising theranostic platform. In order to improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles (PMs), decorated with folic acid moieties and tested in vivo for Photoacustic (PA) and MRI detection of ovarian cancer.
April 28, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28449541/nanoscale-observation-of-dehydration-process-in-phema-hydrogel-structure
#4
Kordian Chamerski, Witold Korzekwa, Jacek Filipecki, Olha Shpotyuk, Marcin Stopa, Piotr Jeleń, Maciej Sitarz
One of the most important field of interest in respect to hydrogel materials is their capability to water storage. The problem mentioned above plays an important role regarding to diffusion of fluid media containing nanoparticles, what is very useful in biomedical applications, such as artificial polymeric implants, drug delivery systems or tissue engineering.In presented work, dehydration process in hydrogels used in ophthalmology as intraocular lenses was observed. Before measurements studied materials were immersed in deionized water and saline solution to obtain equilibrium swelling state...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28448900/dual-responsive-magnetic-composite-nanogels-for-thermo-chemotherapy
#5
S Indulekha, P Arunkumar, D Bahadur, R Srivastava
With the onset of hyperthermia and their advantage in increasing vascular perfusion and permeability in the cancer milieu, thermo-responsive polymers have become an attractive candidate for designing therapeutic nano-vehicles for targeted on-demand delivery of bioactive agents. For this purpose, we developed a dual (thermo- and pH-) responsive nanotherapeutic composite system rendering a combinational therapy of hyperthermia mediated drug delivery. This composite system comprises of magnetic chitosan-g-PNVCL (MCP) polymeric nanogels loaded with anticancer drug, Doxorubicin (DOX)...
April 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28447548/preparation-of-wormlike-polymeric-nanoparticles-coated-with-silica-for-delivery-of-methotrexate-and-evaluation-of-anticancer-activity-against-mcf7-cells
#6
Farhad Gharebaghi, Naser Dalali, Ebrahim Ahmadi, Hossein Danafar
Methotrexate is one of the most effective drugs that is commonly used in the treatment of cancer. However, its application is limited due to low solubility, high toxicity and rapid metabolism. Therefore, in the present study, worm-like polymeric nanoparticles as carrier of methotrexate were prepared using biodegradable copolymers (mPEG-PCL). The impact of nanoparticles' geometry on the loading, delivery and drug's anti-cancer activity was investigated. The di-block copolymer mPEG-PCL was being synthesized by a ring opening polymerization of ɛ-caprolactone in the presence of mPEG as the initiator and Sn(oct)2 as the catalyst...
April 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28446340/peptide-dendrimer-lipid-conjugates-as-dna-and-sirna-transfection-reagents-role-of-charge-distribution-across-generations
#7
Marc Heitz, Albert Kwok, Gabriela A Eggimann, Florian Hollfelder, Tamis Darbre, Jean-Louis Reymond
Transfection reagents are used to deliver DNA and siRNA into cells to achieve genetic manipulations, and may ultimately enable nonviral gene therapy. Progress in transfection reagents is limited by the fact that such reagents cannot be easily optimized due to their polymeric nature and/or difficult synthesis. We have developed a new class of well-defined and easily modifiable transfection reagents in the form of peptide dendrimers. These dendrimers self-assemble with DNA or siRNA and lipofectin to form nanoparticles which efficiently enter mammalian cells and liberate their nucleic acid cargo...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28443840/effect-of-incorporating-flat-aromatic-molecules-on-spherical-polymeric-nanoparticles
#8
Piyachai Khomein, S Thayumanavan
Flat aromatic structures are ubiquitous in organic semiconducting molecules. The possibility of endowing these inherently anisotropic molecules with isotropic structures is explored using a polymeric nanoparticle attachment strategy. Preliminary findings, outlined in this manuscript, suggest that this might be a simple and effective strategy for organic semiconductors with consistent mobilities.
April 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28442408/plasma-membrane-activatable-polymeric-nanotheranostics-with-self-enhanced-light-triggered-photosensitizer-cell-influx-for-photodynamic-cancer-therapy
#9
Hao-Ran Jia, Yao-Wen Jiang, Ya-Xuan Zhu, Yan-Hong Li, Hong-Yin Wang, Xiaofeng Han, Zhi-Wu Yu, Ning Gu, Peidang Liu, Zhan Chen, Fu-Gen Wu
To address the issue of low cellular uptake of photosensitizers by cancer cells in photodynamic therapy (PDT), we designed a smart plasma membrane-activatable polymeric nanodrug by conjugating the photosensitizer protoporphyrin IX (PpIX) and polyethylene glycol (PEG) with glycol chitosan (GC). The as-prepared GC-PEG-PpIX can self-assemble into core-shell nanoparticles (NPs) in aqueous solution and the fluorescence of PpIX moieties in the inner core is highly quenched due to strong π-π stacking. Interestingly, when encountering plasma membranes, the GC-PEG-PpIX NPs can disassemble and stably attach to plasma membranes due to the membrane affinity of PpIX moieties, which effectively suppresses the self-quenching of PpIX, leading to significantly enhanced fluorescence and singlet oxygen ((1)O2) production upon laser irradiation...
April 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28440967/toxicity-of-cisplatin-loaded-poly-butyl-cyanoacrylate-nanoparticles-in-a-brain-cancer-cell-line-anionic-polymerization-results
#10
Nejad Mohamadi, S Maryam Kazemi, Mahshid Mohammadian, Attabak Toofani Milani, Younes Moradi, Maryam Yasemi, Meysam Ebrahimi far, Maral Mazloumi Tabrizi, Hasan Ebrahimi Shahmabadi, Azim Akbarzadeh Khiyavi
Cancer is one of the most important issues in modern medicine and the most common cause of death after cardiovascular diseases in many countries. Brain cancer is one of the most common causes of cancer death among men and women, ranking third. Chemotherapeutic drugs that aim to prevent uncontrolled proliferation of cells in tissues of the body and induce apoptosis of tumor cells are prominent candidates for development. Since cisplatin has an apoptosisinducing role, it is widely used as an anticancer agent...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28440835/the-generation-of-compartmentalized-nanoparticles-containing-sirna-and-cisplatin-using-a-multi-needle-electrohydrodynamic-strategy
#11
Maria F Pina, Wai Lau, Kathrin Scherer, Maryam Parhizkar, Mohan Edirisinghe, Duncan Craig
This study outlines a novel manufacturing technique for the generation of compartmentalized trilayered nanoparticles loaded with an anti-cancer agent and siRNA as a platform for the combination treatment of cancers. More specifically, we describe the use of a multi-needle electrohydrodynamic approach to produce nanoparticles with high size specificity and scalable output, while allowing suitable environments for each therapeutic agent. The inner polylactic-glycolic-acid (PLGA) layer was loaded with cisplatin while the middle chitosan layer was loaded with siRNA...
April 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28440621/gas-phase-sensing-of-alcohols-by-metal-organic-framework-polymer-composite-materials
#12
Sumit Sachdeva, Sander J H Koper, Anahid Sabetghadam, Dimitri Soccol, Dirk J Gravesteijn, Freek Kapteijn, Ernst J R Sudhölter, Jorge Gascon, Louis C P M de Smet
Affinity layers play a crucial role in chemical sensors for the selective and sensitive detection of analytes. Here, we report the use of composite affinity layers containing Metal Organic Frameworks (MOFs) in a polymeric matrix for sensing purposes. Nanoparticles of NH2-MIL-53(Al) were dispersed in a Matrimid polymer matrix with different weight ratios (0-100 wt %) and drop-casted on planar capacitive transducer devices. These coated devices were electrically analyzed using impedance spectroscopy and investigated for their sensing properties toward the detection of a series of alcohols and water in the gas phase...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28437729/evaluation-of-the-effects-of-polymeric-chitosan-tripolyphosphate-and-solid-lipid-nanoparticles-on-germination-of-zea-mays-brassica-rapa-and-pisum-sativum
#13
Daniele Y Nakasato, Anderson E S Pereira, Jhones L Oliveira, Halley C Oliveira, Leonardo F Fraceto
Although the potential toxicity of many metallic and carbon nanoparticles to plants has been reported, few studies have evaluated the phytotoxic effects of polymeric and solid lipid nanoparticles. The present work described the preparation and characterization of chitosan/tripolyphosphate (CS/TPP) nanoparticles and solid lipid nanoparticles (SLN) and evaluated the effects of different concentrations of these nanoparticles on germination of Zea mays, Brassica rapa, and Pisum sativum. CS/TPP nanoparticles presented an average size of 233...
April 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28437702/cascade-post-polymerization-modification-of-single-pentafluorophenyl-ester-bearing-homopolymer-as-a-facile-route-to-redox-responsive-nanogels
#14
Susita Noree, Varawut Tangpasuthadol, Suda Kiatkamjornwong, Voravee P Hoven
Poly(pentafluorophenyl methacrylate) (PPFPMA) was first subjected to post-polymerization modification with oligo(ethylene glycol) methyl ether amine (OEG-NH2) and yielded poly(pentafluorophenyl methacrylate)-co-poly(oligo(ethylene glycol methacrylamide)), PPFPMA-co-POEGMAM. These amphiphilic random copolymers can self-assemble into micellar nanoparticles in water having sizes less than 100nm. By tandemly reacting the pentafluorophenyl (PFP) groups in the copolymeric nanoparticles with a dithiol crosslinker, cystamine, redox-responsive nanogels can be formed...
April 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28437627/tumor-acidity-activatable-tat-targeted-nanomedicine-for-enlarged-fluorescence-magnetic-resonance-imaging-guided-photodynamic-therapy
#15
Meng Gao, Feng Fan, Dongdong Li, Yue Yu, Kuirong Mao, Tianmeng Sun, Haisheng Qian, Wei Tao, Xianzhu Yang
Nanoparticles simultaneously integrated the photosensitizers and diagnostic agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). However, the diagnostic sensitivity and therapeutic efficacy of nanoparticles as well as the heterogeneity of tumors pose tremendous challenges for clinical imaging-guided PDT treatment. Herein, a polymeric nanoparticle with tumor acidity (pHe)-activatable TAT targeting ligand that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates contrast agent Gd(3+) is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28436963/a-sting-activating-nanovaccine-for-cancer-immunotherapy
#16
Min Luo, Hua Wang, Zhaohui Wang, Haocheng Cai, Zhigang Lu, Yang Li, Mingjian Du, Gang Huang, Chensu Wang, Xiang Chen, Matthew R Porembka, Jayanthi Lea, Arthur E Frankel, Yang-Xin Fu, Zhijian J Chen, Jinming Gao
The generation of tumour-specific T cells is critically important for cancer immunotherapy. A major challenge in achieving a robust T-cell response is the spatiotemporal orchestration of antigen cross-presentation in antigen-presenting cells with innate stimulation. Here, we report a minimalist nanovaccine, comprising a simple physical mixture of an antigen and a synthetic polymeric nanoparticle, PC7A NP, which generates a strong cytotoxic T-cell response with low systemic cytokine expression. Mechanistically, the PC7A NP achieves efficient cytosolic delivery of tumour antigens to antigen-presenting cells in draining lymph nodes, leading to increased surface presentation while simultaneously activating type I interferon-stimulated genes...
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28435252/polyphenol-nanoformulations-for-cancer-therapy-experimental-evidence-and-clinical-perspective
#17
REVIEW
Yasamin Davatgaran-Taghipour, Salar Masoomzadeh, Mohammad Hosein Farzaei, Roodabeh Bahramsoltani, Zahra Karimi-Soureh, Roja Rahimi, Mohammad Abdollahi
Cancer is defined as the abnormal cell growth that can cause life-threatening malignancies with high financial costs for patients as well as the health care system. Natural polyphenols have long been used for the prevention and treatment of several disorders due to their antioxidant, anti-inflammatory, cytotoxic, antineoplastic, and immunomodulatory effects discussed in the literature; thus, these phytochemicals are potentially able to act as chemopreventive and chemotherapeutic agents in different types of cancer...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28433944/evaluation-of-vaccinal-effectiveness-of-preparations-containing-membrane-antigens-of-leishmania-l-amazonensis-in-experimental-cutaneous-leishmaniasis-model
#18
João G Ribeiro, Amália S Ferreira, Sharon R A Macedo, Norton R D L P Rossi, Mayara C P da Silva, Rosane N M Guerra, Neuza B de Barros, Roberto Nicolete
American tegumentary leishmaniasis (ATL) is considered a neglected disease, for which an effective vaccine or an efficient diagnosis is not yet available and whose chemotherapeutic arsenal is threatened by the emergence of resistance by etiological agents such as Leishmania amazonensis. ATL is endemic in poor countries and has a high incidence in Brazil. Vaccines developed from native parasite fractions have led to the identification of defined antigenic subunits and the development of vaccine adjuvant technology...
April 20, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28433942/synthesis-and-characterization-of-poly-propylene-imine-dendrimer-grafted-gold-nanoparticles-as-nanocarriers-of-doxorubicin
#19
Marzieh Golshan, Mehdi Salami-Kalajahi, Mina Mirshekarpour, Hossein Roghani-Mamaqani, Maryam Mohammadi
The aim of current work is synthesis 4th-generation-poly(propylene imine) (PPI)-dendrimer modified gold nanoparticles (Au-G4A) as nanocarriers for doxorubicin (DOX) and studying in vitro drug release kinetics from nanocarriers into different media. Accordingly, AuNPs were synthesized by reduction of chloroauric acid (HAuCl4) aqueous solution with trisodium citrate and modified with cysteamine to obtain amine-functionalized (Au-NH2) nanoparticles. Au-NH2 nanoparticles were used as multifunctional cores and participated in Michael addition of acrylonitrile and reduction process by lithium aluminum hydride (LAH) to synthesize Au-G4A nanoparticles...
April 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28433918/chronic-responses-of-aerobic-granules-to-zinc-oxide-nanoparticles-in-a-sequencing-batch-reactor-performing-simultaneous-nitrification-denitrification-and-phosphorus-removal
#20
Qiulai He, Shuxian Gao, Shilu Zhang, Wei Zhang, Hongyu Wang
The reactor performance, granules characteristics and microbial population dynamics were investigated to assess the chronic responses of aerobic granules to zinc oxide nanoparticles (ZnO NPs) of 0, 5, 10 and 20mg/L for a period of 180days. The results showed that ZnO NPs stimulated COD removal, whereas caused inhibition to both nitrification and denitrification. However, biological phosphorus removal remained effective and stable. Introduction of ZnO NPs sharply decreased the respiration of granules, while did not change the settleability...
April 7, 2017: Bioresource Technology
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