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polymeric nanoparticles

Yijie Zhou, Aibin Huang, Huaijuan Zhou, Shidong Ji, Ping Jin
Research on functional flexible films has been attracting widespread attention especially those foils which could be designed artificially on the base of the practical requirements. In this work, foil with high visible reflection and strong near infrared shielding efficiency was prepared by simple wet chemical methods. In the process of making this kind of optical foil, emulsion polymerization was first introduced to synthesize polymer opals which were further compressed between two pieces of polyethylene terephthalate (PET) foils under polymer melting temperature to obtain photonic crystal film with strong reflection in visible region to block blue ray...
December 8, 2017: Nanotechnology
Jiaming Hu, Yan Sheng, Junfeng Shi, Bohao Yu, Zhiqiang Yu, Guochao Liao
The major limitation in the improving polymeric nanoparticles into an efficient gene/drug delivery carrier is the rapid opsonization, phagocytic uptake by mononuclear phagocyte system and subsequent clearance from the bloodstream. The prolonged circulation time of nanoparticles in the blood is a prerequisite to realizing a controlled and targeted (passive or active targeting) release of the encapsulated gene/drug at the desired site of action. In this review, the factors such as biological barriers and physical barriers including particle size, shape, zeta potential, and hydrophilicity will be discussed, which can cause effects on blood clearance and organ accumulation...
December 7, 2017: Current Drug Metabolism
Verena M Weiss, Henrike Lucas, Thomas Mueller, Petr Chytil, Tomáš Etrych, Toufik Naolou, Jörg Kressler, Karsten Mäder
Biodegradable nanoparticles based on stearic acid-modified poly(glycerol adipate) (PGAS) are promising carriers for drug delivery. In order to investigate the impact of the particle interface characteristics on the biological fate, PGAS nanoparticles are covalently and noncovalently coated with N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers. HPMA copolymer-modified PGAS nanoparticles have similar particle sizes, but less negative zeta-potentials. Nanoparticles are double labeled with the fluorescent dyes DiR (noncovalently) and DYOMICS-676 (covalently bound to HPMA copolymer), and their biodistribution is investigated noninvasively by multispectral optical imaging...
December 8, 2017: Macromolecular Bioscience
Vahid Abbasian, Ehsan A Akhlaghi, Mohammad A Charsooghi, Maasoomeh Bazzar, Ali-Reza Moradi
The aim of this paper is to introduce digital holographic microscopy (DHM) as a non-contact, inexpensive, and non-abrasive method for 3D surface characterization of polymeric nanocomposites. A common-path and vibration-immune Mirau system with a microsphere-assisted arrangement is utilized to increase the lateral resolution of the images. The characterization is performed through the measurement of roughness parameters of the surfaces, which are derived from the recorded holograms. Pure poly(triazole-amide-imide) (PTAI) and PTAI nanocomposite reinforeced with surface modified TiO2 nanoparticles (MN-TiO2) are used and compared...
November 28, 2017: Ultramicroscopy
Maya Juenet, Rachida Aid-Launais, Bo Li, Alice Berger, Joël Aerts, Véronique Ollivier, Antonino Nicoletti, Didier Letourneur, Cédric Chauvierre
Injection of recombinant tissue plasminogen activator (rt-PA) is the standard drug treatment for thrombolysis. However, rt-PA shows risk of hemorrhages and limited efficiency even at high doses. Polysaccharide-poly(isobutylcyanoacrylate) nanoparticles functionalized with fucoidan and loaded with rt-PA were designed to accumulate on the thrombus. Fucoidan has a nanomolar affinity for the P-selectin expressed by activated platelets in the thrombus. Solid spherical fluorescent nanoparticles with a hydrodynamic diameter of 136 ± 4 nm were synthesized by redox radical emulsion polymerization...
November 29, 2017: Biomaterials
Samad Hosseini Sadr, Soodabeh Davaran, Effat Alizadeh, Roya Salehi, Ali Ramazani
Great efforts have been made to develop drug carriers with the aim of providing predictable therapeutic response. Moreover, combination therapies have become promising strategies for clinical cancer treatment with synergistic effects. The present study purposed to develop a new stimuli-responsive paramagnetic nanocarrier for the intracellular co-delivery of doxorubicin (DOX) and methotrexate (MTX) to the MCF7 cell line. A novel thermo/pH-sensitive amphiphilic paramagnetic nanocomposite comprised of hydrophobic and biodegradable PCL segments and a hydrophilic biocompatible P(NIPAAm-co-HEMA-co-MAA-co-TMSPMA) block was designed and synthesized by combining the ring opening and free radical polymerization methods...
December 7, 2017: Journal of Biomaterials Science. Polymer Edition
Jeong In Choi, Song Ji Chae, Jung Min Kim, Jae Chun Choi, Se Jong Park, Hee Ju Choi, Hojae Bae, Hyun Jin Park
In recent years, silver nanoparticles (AgNPs) have been extensively employed in food packaging systems as a potential antibacterial agent. Although proven to be highly effective, increased number of AgNP-containing products raises concerns among consumers regarding the migration of AgNPs from the packaging material into foods which may exert toxic effects. To address this, five baby products were chosen (baby bottle A, baby bottle B, pacifier A, pacifier B, and breastmilk storage bag) to investigate AgNPs migration into three food simulants (deionized water, 4% acetic acid (w/v), and 50% ethanol (v/v)) using inductively coupled plasma mass spectrometry (ICP-MS)...
December 6, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Andreas Picker, Luc Nicoleau, Zaklina Burghard, Joachim Bill, Igor Zlotnikov, Christophe Labbez, André Nonat, Helmut Cölfen
Calcium silicate hydrate (C-S-H) is the binder in concrete, the most used synthetic material in the world. The main weakness of concrete is the lack of elasticity and poor flexural strength considerably limiting its potential, making reinforcing steel constructions necessary. Although the properties of C-S-H could be significantly improved in organic hybrids, the full potential of this approach could not be reached because of the random C-S-H nanoplatelet structure. Taking inspiration from a sea urchin spine with highly ordered nanoparticles in the biomineral mesocrystal, we report a bioinspired route toward a C-S-H mesocrystal with highly aligned C-S-H nanoplatelets interspaced with a polymeric binder...
November 2017: Science Advances
Guangjian Zeng, Meiying Liu, Ruming Jiang, Qiang Huang, Long Huang, Qing Wan, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
In recent years, the fluorescent polymeric nanoparticles (FPNs) with aggregation-induced emission (AIE) feature have been extensively exploited in various biomedical fields owing to their advantages, such as low toxicity, biodegradation, excellent biocompatibility, good designability and optical properties. Therefore, development of a facile, efficient and well designable strategy should be of great importance for the biomedical applications of these AIE-active FPNs. In this work, a novel method for the fabrication of AIE-active FPNs has been developed through the self-catalyzed photo-initiated reversible addition fragmentation chain transfer (RAFT) polymerization using an AIE dye containing chain transfer agent (CTA), which could initiate the RAFT polymerization under light irradiation...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Ruming Jiang, Long Huang, Meiying Liu, Fengjie Deng, Hongye Huang, Jianwen Tian, Yuanqing Wen, Qian-Yong Cao, Xiaoyong Zhang, Yen Wei
The fabrication and biomedical applications of fluorescent polymeric nanoparticles (FPNs) with aggregation-induced emission (AIE) feature has attracted the most intensive research interest since the first discovery of AIE phenomenon by Tang' group. Although great attention has been devoted to preparation of AIE-active FPNs, an efficient, facile and versatile strategy is still highly desirable to advance their biomedical applications. In this work, a one-pot microwave-assisted multicomponent tandem polymerization was proposed to fabricate AIE-active FPNs based on a microwave-assisted Kabachnik-Fields (KF) reaction, which involves the conjugation of aldehyde group containing polyethylene glycol (CHO-PEG-CHO) and amino-group terminating AIE dye (H2N-PhE-NH2) using diethyl phosphate as the lock...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Rong Dai, Yi Zhang, Zhen-Qiang Shi, Fan Yang, Chang-Sheng Zhao
A facile and environmental-friendly approach was developed to prepare magnetic nano-adsorbent for environmental pollutant removal. Based on the mussel-inspired polymerization, amino-coated Fe3O4 nanoparticles were fabricated by simply immersing Fe3O4 nanoparticles into an aqueous solution of catechol and hexanediamine with stirring at room temperature. The magnetic nano-adsorbent was characterized via Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermo gravimetric analysis (TGA), and Brunauer-Emmett-Teller's test (BET)...
November 26, 2017: Journal of Colloid and Interface Science
Junxia Zhang, Liqin Chao, Xianghua Liu, Yanmei Shi, Caili Zhang, Lingfei Kong, Ruiqin Li
AIM: The capability of reducing fibrotic and inflammatory responses in lung tissues represents a gold standard for evaluating the efficacy of therapeutic interventions for treating idiopathic pulmonary fibrosis (IPF). A wide variety of therapeutic strategies have been employed in clinic to treat PF, but limited success has been obtained. Apigenin (4, 5, 7-trihydroxyflavone) is a member of flavonoid family that exerts anti-inflammatory and anti-fibrosis effects. In this study, we explore the potential therapeutic effect of apigenin in lung fibrosis...
December 5, 2017: Experimental Lung Research
Angel J Moreno, Petra Bacova, Federica Lo Verso, Arantxa Arbe, Juan Colmenero, Jose A Pomposo
Polymeric single-chain nanoparticles (SCNPs) are soft nano-objects synthesized by purely intramolecular cross-linking of single polymer chains. By means of computer simulations, we investigate the conformational properties of SCNPs as a function of the bending stiffness of their linear polymer precursors. We investigate a broad range of characteristic ratios from the fully flexible case to those typical of bulky synthetic polymers. Increasing stiffness hinders bonding of groups separated by short contour distances and increases looping over longer distances, leading to more compact nanoparticles with a structure of highly interconnected loops...
December 5, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Song Wang, Jiaxu Li, Mengfei Qi, Xiang Gao, Wen-Jun Wang
Macroporous materials polymerized from high internal phase emulsions (PolyHIPEs) possess well-defined interconnected porous structures and tunable device shapes. This provides interesting property characteristics well-suited for a variety of applications. However, such materials also demonstrate poor mechanical performances, which limit their potential use. As will be demonstrated, this results from the high surfactant content required by PolyHIPEs. Herein, a new approach is introduced for designing a highly efficient polymeric surfactant, which generates interconnected pores in PolyHIPEs through designing an incompatible surfactant and skeleton material...
December 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Mohammad Ali Salami, Faranak Kaveian, Mohammad Rafienia, Saeed Saber-Samandari, Amirsalar Khandan, Mitra Naeimi
Background: Biopolymer scaffolds have received great interest in academic and industrial environment because of their supreme characteristics like biological, mechanical, chemical, and cost saving in the biomedical science. There are various attempts for incorporation of biopolymers with cheap natural micro- or nanoparticles like lignin (Lig), alginate, and gums to prepare new materials with enhanced properties. Methods: In this work, the electrospinning (ELS) technique as a promising cost-effective method for producing polymeric scaffold fibers was used, which mimics extracellular matrix structure for soft tissue engineering applications...
October 2017: Journal of Medical Signals and Sensors
Kareem Ebeid, Xiangbing Meng, Kristina W Thiel, Anh-Vu Do, Sean M Geary, Angie S Morris, Erica L Pham, Amaraporn Wongrakpanich, Yashpal S Chhonker, Daryl J Murry, Kimberly K Leslie, Aliasger K Salem
Uterine serous carcinoma, one of the most aggressive types of endometrial cancer, is characterized by poor outcomes and mutations in the tumour suppressor p53. Our objective was to engender synthetic lethality to paclitaxel (PTX), the frontline treatment for endometrial cancer, in tumours with mutant p53 and enhance the therapeutic efficacy using polymeric nanoparticles (NPs). First, we identified the optimal NP formulation through comprehensive analyses of release profiles and cellular-uptake and cell viability studies...
December 4, 2017: Nature Nanotechnology
Sheldon Berke, Anne-Larissa Kampmann, Melinda Wuest, Justin J Bailey, Britta Glowacki, Frank Wuest, Klaus Jurkschat, Ralf Weberskirch, Ralf Schirrmacher
Nanoparticles represent the most widely studied drug delivery systems targeting cancer. Polymeric nanoparticles can be easily generated through a microemulsion polymerization. Herein, the synthesis, radiolabeling, and in vivo evaluation of nanoparticles (NPs) functionalized by an organosilicon fluoride acceptor (SiFA) are reported which can be radiolabeled without further chemical modifications. Four nanoparticles in the sub-100 nm range with distinct hydrodynamic diameters of 20 nm (NP1), 33 nm (NP2), 45 nm (NP3), and 72 nm (NP4), respectively, were synthesized under size-controlled conditions...
December 4, 2017: Bioconjugate Chemistry
Anderson Nogueira Mendes, Lívia Alves Filgueiras, Monica Regina Pimentel Siqueira, Gleyce Moreno Barbosa, Carla Holandino, Davyson de Lima Moreira, José Carlos Pinto, Marcio Nele
This study aimed to synthesize and characterize nanoparticles (NPs) of poly(methyl methacrylate) (PMMA) and evaluate their ability to incorporate plant extracts with antitumor activity and low dissolution in aqueous media. The extract used was n-hexane partition of the methanol extract of Piper cabralanum (PCA-HEX). PMMA NPs were obtained using the mini-emulsion method, which was able to encapsulate almost 100% of PCA-HEX. The synthesized polymeric particles presented with a size of 200 nm and a negative charge...
2017: International Journal of Nanomedicine
Tanveer A Tabish, Shaowei Zhang, Paul G Winyard
Graphene has a promising future in applications such as disease diagnosis, cancer therapy, drug/gene delivery, bio-imaging and antibacterial approaches owing to graphene's unique physical, chemical and mechanical properties alongside minimal toxicity to normal cells, and photo-stability. However, these unique features and bioavailability of graphene are fraught with uncertainties and concerns for environmental and occupational exposure. Changes in the physicochemical properties of graphene affect biological responses including reactive oxygen species (ROS) production...
November 22, 2017: Redox Biology
Sergio Martín-Saldaña, Raquel Palao-Suay, María Rosa Aguilar, Luis García-Fernández, Humberto Arévalo, Almudena Trinidad, Rafael Ramírez-Camacho, Julio San Román
Polymeric nanoparticles (NP) based on smart synthetic amphiphilic copolymers are used to transport and controlled release dexamethasone in the inner ear to protect against the ototoxic effect of cisplatin. The NP were based on a mixture of two pseudo-block polymer drugs obtained by free radical polymerization: poly(VI-co-HEI) and poly(VP-co-MVE) or poly(VP-co-MTOS), being VI 1-vinylimidazole, VP N-vinylpyrrolidone, and IBU, MVE and MTOS the methacrylic derivatives of ibuprofen, α-tocopherol and α-tocopheryl succinate, respectively...
November 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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