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Dyskinetic cerebral palsy and dystonia

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https://www.readbyqxmd.com/read/29148568/intrathecal-baclofen-in-dyskinetic-cerebral-palsy-effects-on-function-and-activity
#1
Meta N Eek, Kristina Olsson, Karin Lindh, Berit Askljung, Magnus Påhlman, Olle Corneliusson, Kate Himmelmann
AIM: To investigate the effect of intrathecal baclofen (ITB) on function and activity in dyskinetic cerebral palsy (CP). METHOD: A retrospective cohort study of records from 25 children (15 males, 10 females; mean age 10y 11mo, SD 4y 9mo). Five were classified in Gross Motor Function Classification level IV and 20 in level V. Parents were interviewed about activities in daily life, sitting, communication, pain, sleep, and gross and fine motor function. Differences before and 1 year after ITB were graded as positive, no change, or negative...
November 17, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29090508/identification-classification-and-assessment-of-dyskinesia-in-children-with-cerebral-palsy-a-survey-of-clinicians
#2
Kirsty Stewart, Emma Tavender, James Rice, Adrienne Harvey
AIM: The aims of this study were to investigate clinicians' knowledge, and barriers they perceive exist, relating to the identification and measurement of dyskinesia (dystonia/choreoathetosis) in children with cerebral palsy (CP) and to explore educational needs regarding improving identification and assessment of dyskinesia. METHODS: This was a cross-sectional online survey of clinicians working with children with CP. Data analysis was descriptive, with qualitative analysis of unstructured questions...
October 31, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28816119/clinical-presentation-and-management-of-dyskinetic-cerebral-palsy
#3
REVIEW
Elegast Monbaliu, Kate Himmelmann, Jean-Pierre Lin, Els Ortibus, Laura Bonouvrié, Hilde Feys, R Jeroen Vermeulen, Bernard Dan
Cerebral palsy is the most frequent cause of severe physical disability in childhood. Dyskinetic cerebral palsy (DCP) is the second most common type of cerebral palsy after spastic forms. DCP is typically caused by non-progressive lesions to the basal ganglia or thalamus, or both, and is characterised by abnormal postures or movements associated with impaired tone regulation or movement coordination. In DCP, two major movement disorders, dystonia and choreoathetosis, are present together most of the time. Dystonia is often more pronounced and severe than choreoathetosis, with a major effect on daily activity, quality of life, and societal participation...
September 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28549726/spasticity-dyskinesia-and-ataxia-in-cerebral-palsy-are-we-sure-we-can-differentiate-them
#4
H Eggink, D Kremer, O F Brouwer, M F Contarino, M E van Egmond, A Elema, K Folmer, J F van Hoorn, L A van de Pol, V Roelfsema, M A J Tijssen
OBJECTIVE: Cerebral palsy (CP) can be classified as spastic, dyskinetic, ataxic or combined. Correct classification is essential for symptom-targeted treatment. This study aimed to investigate agreement among professionals on the phenotype of children with CP based on standardized videos. METHODS: In a prospective, observational pilot study, videos of fifteen CP patients (8 boys, mean age 11 ± 5 y) were rated by three pediatric neurologists, three rehabilitation physicians and three movement disorder specialists...
September 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28511835/adcy5-related-movement-disorders-frequency-disease-course-and-phenotypic-variability-in-a-cohort-of-paediatric-patients
#5
Miryam Carecchio, Niccolò E Mencacci, Alessandro Iodice, Roser Pons, Celeste Panteghini, Giovanna Zorzi, Federica Zibordi, Anastasios Bonakis, Argyris Dinopoulos, Joseph Jankovic, Leonidas Stefanis, Kailash P Bhatia, Valentina Monti, Lea R'Bibo, Liana Veneziano, Barbara Garavaglia, Carlo Fusco, Nicholas Wood, Maria Stamelou, Nardo Nardocci
INTRODUCTION: ADCY5 mutations have been recently identified as an important cause of early-onset hyperkinetic movement disorders. The phenotypic spectrum associated with mutations in this gene is expanding. However, the ADCY5 mutational frequency in cohorts of paediatric patients with hyperkinetic movement disorders has not been evaluated. METHODS: We performed a screening of the entire ADCY5 coding sequence in 44 unrelated subjects with genetically undiagnosed childhood-onset hyperkinetic movement disorders, featuring chorea alone or in combination with myoclonus and dystonia...
August 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28485494/a-systematic-review-of-scales-to-measure-dystonia-and-choreoathetosis-in-children-with-dyskinetic-cerebral-palsy
#6
REVIEW
Kirsty Stewart, Adrienne Harvey, Leanne M Johnston
AIM: To identify and systematically review the psychometric properties and clinical utility of dystonia and choreoathetosis scales reported for children with cerebral palsy (CP). METHOD: Six electronic databases were searched for dystonia and choreoathetosis scales with original psychometric data for children with CP aged 0 to 18 years. RESULTS: Thirty-four papers met the inclusion criteria, which contained six scales purported to measure dystonia and/or choreoathetosis in children with CP: the Burke-Fahn-Marsden Dystonia Rating Scale; Barry-Albright Dystonia Scale; Unified Dystonia Rating Scale; Movement Disorder-Childhood Rating Scale; Movement Disorder-Childhood Rating Scale 0-3 Years; and the Dyskinesia Impairment Scale...
August 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28272743/functional-outcomes-in-children-and-young-people-with-dyskinetic-cerebral-palsy
#7
Elegast Monbaliu, Mary-Grace De La Peña, Els Ortibus, Guy Molenaers, Jan Deklerck, Hilde Feys
AIM: This cross-sectional study aimed to map the functional profile of individuals with dyskinetic cerebral palsy (CP), to determine interrelationships between the functional classification systems, and to investigate the relationship of functional abilities with dystonia and choreoathetosis severity. METHODS: Fifty-five children (<15y) and young people (15-22y) (30 males, 25 females; mean age 14y 6mo, standard deviation 4y 1mo) with dyskinetic CP were assessed using the Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), Communication Function Classification System (CFCS), Eating and Drinking Ability Classification System (EDACS), and Viking Speech Scale (VSS), as well as the Dyskinesia Impairment Scale...
June 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28017556/bilateral-globus-pallidus-internus-deep-brain-stimulation-for-dyskinetic-cerebral-palsy-supports-success-of-cochlear-implantation-in-a-5-year-old-ex-24%C3%A2-week-preterm-twin-with-absent-cerebellar-hemispheres
#8
Jean-Pierre Lin, Margaret Kaminska, Sarah Perides, Hortensia Gimeno, Lesley Baker, Daniel E Lumsden, Anzell Britz, Sandra Driver, Alec Fitzgerald-O'Connor, Richard Selway
BACKGROUND: Early onset dystonia (dyskinesia) and deafness in childhood pose significant challenges for children and carers and are the cause of multiple disability. It is particularly tragic when the child cannot make use of early cochlear implantation (CI) technology to relieve deafness and improve language and communication, because severe cervical and truncal dystonia brushes off the magnetic amplifier behind the ears. Bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) neuromodulation can reduce dyskinesia, thus supporting CI neuromodulation success...
January 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27836441/stable-cognitive-functioning-with-improved-perceptual-reasoning-in-children-with-dyskinetic-cerebral-palsy-and-other-secondary-dystonias-after-deep-brain-stimulation
#9
Tamsin Owen, Dolapo Adegboye, Hortensia Gimeno, Richard Selway, Jean-Pierre Lin
BACKGROUND: Dystonia is characterised by involuntary movements (twisting, writhing and jerking) and postures. Secondary dystonias are described as a heterogeneous group of disorders with both exogenous and endogenous causes. There is a growing body of literature on the effects of deep brain stimulation (DBS) surgery on the motor function in childhood secondary dystonias, however research on cognitive function after DBS is scarce. METHODS: Cognitive function was measured in a cohort of 40 children with secondary dystonia following DBS surgery using a retrospective repeated measures design...
January 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27707657/the-relationship-of-dystonia-and-choreoathetosis-with-activity-participation-and-quality-of-life-in-children-and-youth-with-dyskinetic-cerebral-palsy
#10
Elegast Monbaliu, Paul De Cock, Lisa Mailleux, Bernard Dan, Hilde Feys
AIM: To relate dystonia and choreoathetosis with activity, participation and quality of life (QOL) in children and youth with dyskinetic Cerebral Palsy (CP). METHODS: Fifty-four participants with dyskinetic CP (mean age 14y6m, SD 4y2m, range 6-22y) were included. The Dyskinesia Impairment Scale (DIS) was used to evaluate dystonia and choreoathetosis. Activity, participation and quality of life (QOL) were assessed with the Gross Motor Function Measure (GMFM), the Functional Mobility Scale (FMS), the Jebsen-Taylor Hand Function Test (JTT), the ABILHAND-Kids Questionnaire (ABIL-K), the Life Habits Kids (LIFE-H) and the Quality of Life Questionnaire for children with CP (CP-QOL)...
March 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27707656/the-international-classification-of-functioning-icf-to-evaluate-deep-brain-stimulation-neuromodulation-in-childhood-dystonia-hyperkinesia-informs-future-clinical-research-priorities-in-a-multidisciplinary-model-of-care
#11
MULTICENTER STUDY
Hortensia Gimeno, Jean-Pierre Lin
The multidisciplinary team (MDT) approach illustrates how motor classification systems, assessments and outcome measures currently available have been applied to a national cohort of children and young people with dystonia and other hyperkinetic movement disorders (HMD) particularly with a focus on dyskinetic cerebral palsy (CP). The paper is divided in 3 sections. Firstly, we describe the service model adopted by the Complex Motor Disorders Service (CMDS) at Evelina London Children's Hospital and King's College Hospital (ELCH-KCH) for deep brain stimulation...
January 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27289260/deep-brain-stimulation-in-cerebral-palsy-challenges-and-opportunities
#12
REVIEW
Anne Koy, Lars Timmermann
Cerebral palsy (CP) is the most common cause for acquired dystonia in childhood. Pharmacological treatment is often unsatisfactory and side effects are frequently dose-limiting. Data on outcome of DBS in paediatric patients with dyskinetic CP is very limited and heterogeneous. Reasons for the variability in responses are not entirely known yet. Interestingly, some CP-patients seem to improve subjectively on pallidal stimulation but without measurable changes in impairment scales. Besides dystonia scales, the use of sensitive age-dependent assessments tools is therefore reasonable to capture the full effect...
January 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/26706479/localization-of-basal-ganglia-and-thalamic-damage-in-dyskinetic-cerebral-palsy
#13
REVIEW
Bhooma R Aravamuthan, Jeff L Waugh
BACKGROUND: Dyskinetic cerebral palsy affects 15%-20% of patients with cerebral palsy. Basal ganglia injury is associated with dyskinetic cerebral palsy, but the patterns of injury within the basal ganglia predisposing to dyskinetic cerebral palsy are unknown, making treatment difficult. For example, deep brain stimulation of the globus pallidus interna improves dystonia in only 40% of patients with dyskinetic cerebral palsy. Basal ganglia injury heterogeneity may explain this variability...
January 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/26173923/clinical-patterns-of-dystonia-and-choreoathetosis-in-participants-with-dyskinetic-cerebral-palsy
#14
Elegast Monbaliu, Paul de Cock, Els Ortibus, Lieve Heyrman, Katrijn Klingels, Hilde Feys
AIM: The aim of the study was to map clinical patterns of dystonia and choreoathetosis and to assess the relation between functional classifications and basal ganglia and thalamus lesions in participants with dyskinetic cerebral palsy (CP). METHODS: In this cross-sectional study, 55 participants with dyskinetic CP (mean age 14y 6mo, SD 4y 1mo; range 6-22y) were assessed with the Dyskinesia Impairment Scale and classified with the Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), and Communication Function Classification System (CFCS)...
February 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/25422013/motor-severity-in-children-with-cerebral-palsy-studied-in-a-high-resource-and-low-resource-country
#15
COMPARATIVE STUDY
Katherine A Benfer, Rachel Jordan, Sasaka Bandaranayake, Christine Finn, Robert S Ware, Roslyn N Boyd
OBJECTIVES: To compare the patterns of motor type and gross motor functional severity in preschool-aged children with cerebral palsy (CP) in Bangladesh and Australia. METHODS: We used comparison of 2 prospective studies. A total of 300 children with CP were aged 18 to 36 months, 219 Australian children (mean age, 26.6 months; 141 males) recruited through tertiary and community services, and 81 clinic-attendees born in Bangladesh (mean age, 27.5 months; 50 males)...
December 2014: Pediatrics
https://www.readbyqxmd.com/read/25322688/young-adults-with-dyskinetic-cerebral-palsy-improve-subjectively-on-pallidal-stimulation-but-not-in-formal-dystonia-gait-speech-and-swallowing-testing
#16
Anne Koy, K Amande M Pauls, Pia Flossdorf, Johannes Becker, Eckhard Schönau, Mohammad Maarouf, Thomas Liebig, Oliver Fricke, Gereon R Fink, Lars Timmermann
BACKGROUND: Pharmacological treatment of dyskinetic cerebral palsy (CP) is often ineffective. Data about outcome of deep brain stimulation (DBS) in these patients remains scarce. METHODS: Eight patients with dyskinetic CP and DBS of the Globus Pallidus internus were investigated. Using pre- and postoperative videos the severity of dystonia and changes thereof during standardized settings ('on') and after the stimulator had been switched off ('off') were assessed using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS)...
2014: European Neurology
https://www.readbyqxmd.com/read/24855613/neuroradiological-and-neurophysiological-characteristics-of-patients-with-dyskinetic-cerebral-palsy
#17
Byung-Hyun Park, Sung-Hee Park, Jeong-Hwan Seo, Myoung-Hwan Ko, Gyung-Ho Chung
OBJECTIVE: To investigate neuroradiological and neurophysiological characteristics of patients with dyskinetic cerebral palsy (CP), by using magnetic resonance imaging (MRI), voxel-based morphometry (VBM), diffusion tensor tractography (DTT), and motor evoked potential (MEP). METHODS: Twenty-three patients with dyskinetic CP (13 males, 10 females; mean age 34 years, range 16-50 years) were participated in this study. Functional evaluation was assessed by the Gross Motor Functional Classification System (GMFCS) and Barry-Albright Dystonia Scale (BADS)...
April 2014: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/23408442/effects-of-deep-brain-stimulation-in-dyskinetic-cerebral-palsy-a-meta-analysis
#18
Anne Koy, Martin Hellmich, K Amande M Pauls, Warren Marks, Jean-Pierre Lin, Oliver Fricke, Lars Timmermann
Secondary dystonia encompasses a heterogeneous group with different etiologies. Cerebral palsy is the most common cause. Pharmacological treatment is often unsatisfactory. There are only limited data on the therapeutic outcomes of deep brain stimulation in dyskinetic cerebral palsy. The published literature regarding deep brain stimulation and secondary dystonia was reviewed in a meta-analysis to reevaluate the effect on cerebral palsy. The Burke-Fahn-Marsden Dystonia Rating Scale movement score was chosen as the primary outcome measure...
May 2013: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/23177615/can-the-dyskinesia-impairment-scale-be-used-by-inexperienced-raters-a-reliability-study
#19
COMPARATIVE STUDY
Elegast Monbaliu, Els Ortibus, Peter Prinzie, Bernard Dan, Josse De Cat, Paul De Cock, Hilde Feys
BACKGROUND: The Dyskinesia Impairment Scale (DIS) is a new scale for measuring dystonia and choreoathetosis in dyskinetic Cerebral Palsy (CP). Previously, reliability of this scale has only been assessed for raters highly experienced in discriminating between dystonia and choreoathetosis. AIMS: The aims of this study are to examine the reliability of the DIS used by inexperienced raters, new to discriminating between dystonia and choreoathetosis and to determine the effect of clinical expertise on reliability...
May 2013: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/22428172/the-dyskinesia-impairment-scale-a-new-instrument-to-measure-dystonia-and-choreoathetosis-in-dyskinetic-cerebral-palsy
#20
Elegast Monbaliu, Els Ortibus, Jos De Cat, Bernard Dan, Lieve Heyrman, Peter Prinzie, Paul De Cock, Hilde Feys
AIM: The aim of this study was to examine the reliability and validity of the Dyskinesia Impairment Scale (DIS). The DIS consists of two subscales: dystonia and choreoathetosis. It measures both phenomena in dyskinetic cerebral palsy (CP). METHOD: Twenty-five participants with dyskinetic CP (17 males; eight females; age range 5–22y; mean age 13y 6mo; SD 5y 4mo), recruited from special schools for children with motor disorders, were included. Exclusion criteria were changes in muscle relaxant medication within the previous 3 months, orthopaedic or neurosurgical interventions within the previous year, and spinal fusion...
March 2012: Developmental Medicine and Child Neurology
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