Henry M Gomez, Tatt J Haw, Dusan Ilic, Peter Robinson, Chantal Donovan, Amanda J Croft, Kanth S Vanka, Ellen Small, Olivia R Carroll, Richard Y Kim, Jemma R Mayall, Tesfalidet Beyene, Thava Palanisami, Doan Tm Ngo, Graeme R Zosky, Elizabeth G Holliday, Megan E Jensen, Vanessa M McDonald, Vanessa E Murphy, Peter Gibson, Jay C Horvat
BACKGROUND: Millions of people are exposed to landscape fire smoke (LFS) globally and inhalation of LFS particulate matter is associated with poor respiratory and cardiovascular outcomes. However, how LFS affects respiratory and cardiovascular function is less well understood. OBJECTIVE: To characterize the pathophysiological effects of representative LFS airway exposure on respiratory and cardiac function and on asthma outcomes. METHODS: LFS was generated using a customized combustion chamber...
March 19, 2024: Journal of Allergy and Clinical Immunology