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haloperidol delirium

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https://www.readbyqxmd.com/read/27918778/efficacy-of-oral-risperidone-haloperidol-or-placebo-for-symptoms-of-delirium-among-patients-in-palliative-care-a-randomized-clinical-trial
#1
Meera R Agar, Peter G Lawlor, Stephen Quinn, Brian Draper, Gideon A Caplan, Debra Rowett, Christine Sanderson, Janet Hardy, Brian Le, Simon Eckermann, Nicola McCaffrey, Linda Devilee, Belinda Fazekas, Mark Hill, David C Currow
Importance: Antipsychotics are widely used for distressing symptoms of delirium, but efficacy has not been established in placebo-controlled trials in palliative care. Objective: To determine efficacy of risperidone or haloperidol relative to placebo in relieving target symptoms of delirium associated with distress among patients receiving palliative care. Design, Setting, and Participants: A double-blind, parallel-arm, dose-titrated randomized clinical trial was conducted at 11 Australian inpatient hospice or hospital palliative care services between August 13, 2008, and April 2, 2014, among participants with life-limiting illness, delirium, and a delirium symptoms score (sum of Nursing Delirium Screening Scale behavioral, communication, and perceptual items) of 1 or more...
December 5, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27893294/management-of-multifactorial-infant-delirium-with-intravenous-haloperidol-in-the-setting-of-over-sedation-and-poor-enteral-absorption
#2
Erin F Carlton, Madeline K Mahowald, Nasuh Malas
No abstract text is available yet for this article.
November 28, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27881149/antipsychotic-prescribing-patterns-during-and-after-critical-illness-a-prospective-cohort-study
#3
Jason E Tomichek, Joanna L Stollings, Pratik P Pandharipande, Rameela Chandrasekhar, E Wesley Ely, Timothy D Girard
BACKGROUND: Antipsychotics are used to treat delirium in the intensive care unit (ICU) despite unproven efficacy. We hypothesized that atypical antipsychotic treatment in the ICU is a risk factor for antipsychotic prescription at discharge, a practice that might increase risk since long-term use is associated with increased mortality. METHODS: After excluding patients on antipsychotics prior to admission, we examined antipsychotic use in a prospective cohort of ICU patients with acute respiratory failure and/or shock...
November 24, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27858832/comparing-dexmedetomidine-with-haloperidol-for-the-treatment-of-hyperactive-delirium-in-nonintubated-icu-patients
#4
Bryan Dotson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850518/880-evaluation-of-continuous-infusion-haloperidol-for-refractory-agitation-delirium-in-icu-patients
#5
Beatrice Adams, Kevin Ferguson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27830365/haloperidol-prophylaxis-for-preventing-aggravation-of-postoperative-delirium-in-elderly-patients-a-randomized-open-label-prospective-trial
#6
Shinji Fukata, Yasuji Kawabata, Ken Fujishiro, Yuichi Kitagawa, Kojiro Kuroiwa, Hirotoshi Akiyama, Marie Takemura, Masahiko Ando, Hideyuki Hattori
PURPOSES: The aim of this study was to evaluate the safety and efficacy of the early administration haloperidol in preventing the aggravation of postoperative delirium in elderly patients. METHODS: A total of 201 patients (age ≥75 years) who underwent elective surgery were enrolled. The patients were divided into two groups: the intervention group (n = 101) received prophylactic haloperidol (5 mg); the control group (n = 100) did not. Haloperidol was administered daily during postoperative days 0-5 to the patients who presented with NEECHAM scores of 20-24 when measured at 18:00...
November 9, 2016: Surgery Today
https://www.readbyqxmd.com/read/27747805/haloperidol-use-among-elderly-patients-undergoing-surgery-a-retrospective-1-year-study-in-a-hospital-population
#7
Harmke Nijboer, Geert Lefeber, Alidair McLullich, Barbara van Munster
BACKGROUND: Haloperidol, frequently used for delirium, can lead to serious side effects, of which QTc prolongation is the most worrisome since it is associated with an increased risk of fatal cardiac arrhythmia. OBJECTIVES: The aim of this study was to measure the frequency of haloperidol use after procedures in patients aged ≥65 years in a hospital in the Netherlands. METHODS: This was a retrospective study among patients hospitalized in the Netherlands who were aged ≥65 years and who underwent a procedure between January 2008 and January 2009...
March 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27679777/comparative-effectiveness-of-quetiapine-and-haloperidol-in-delirium-a-single-blind-randomized-controlled-study
#8
Sandeep Grover, Sudhir Mahajan, Subho Chakrabarti, Ajit Avasthi
AIM: To evaluate the effectiveness of quetiapine and haloperidol in patients of delirium referred to psychiatry consultation liaison services. METHODS: The study followed a single blind randomised controlled trial design. Thirty-two patients in the haloperidol group and 31 patients in the quetiapine group were assessed at the baseline and 6 consecutive days. Flexible dosing regimen (haloperidol: 0.25-1.25 mg; quetiapine 12.5-75 mg/d) was used. Delirium Rating Scale-Revised-98 (DRS-R-98) and mini mental status examination (MMSE) were the primary and secondary efficacy measures respectively...
September 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/27661210/neuroleptics-in-the-management-of-delirium-in-patients-with-advanced-cancer
#9
David Hui, Rony Dev, Eduardo Bruera
PURPOSE OF REVIEW: Delirium is the most common and distressing neuropsychiatric syndrome in cancer patients. Few evidence-based treatment options are available due to the paucity of high quality of studies. In this review, we shall examine the literature on the use of neuroleptics to treat delirium in patients with advanced cancer. Specifically, we will discuss the randomized controlled trials that examined neuroleptics in the front line setting, and studies that explore second-line options for patients with persistent agitation...
December 2016: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27589986/unsuspected-serotonin-toxicity-in-the-icu
#10
Catharina E van Ewijk, Gabriel E Jacobs, Armand R J Girbes
BACKGROUND: Delirium is a frequently occurring syndrome in patients admitted to the intensive care unit (ICU) or medium care unit (MCU), yet the pathophysiology remains poorly understood. An excess of central serotonin can lead to an altered mental status, associated with autonomic hyperactivity, and neuromuscular excitation. Drugs with serotonergic properties are frequently and for prolonged periods administered to ICU/MCU patients. Therefore, central serotonergic toxicity may constitute a predisposing, contributing or precipitating factor in the emergence of delirium...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27501127/dexmedetomidine-for-the-treatment-of-hyperactive-delirium-refractory-to-haloperidol-in-non-intubated-patients
#11
COMMENT
Ryan O Parker, Adam B King, Christopher G Hughes
No abstract text is available yet for this article.
July 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27353919/look-again-at-psychedelic-drugs
#12
Ruth Cameron
The World Health Organization recommends that anxiety, depression, agitation and delirium at end of life should be treated with drugs such as lorazepam, diazepam, midazolam and haloperidol.
June 29, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27320557/use-of-dexmedetomidine-in-liver-transplant-recipients-with-postoperative-agitated-delirium
#13
J Y Choi, J M Kim, C H D Kwon, J-W Joh, S Lee, J B Park, J S Ko, M S Gwak, G S Kim, S J Kim, S-K Lee
BACKGROUND AND OBJECTIVE: Agitated delirium has frequently occurred after liver transplantation in the intensive care unit (ICU) and sedative agents are used to treat patients. Recently, dexmedetomidine has been considered to be a promising agent for agitated delirium. METHODS: This study took place between January 2010 and October 2012 and 42 recipients were retrospectively enrolled. Sixteen recipients were enrolled in the dexmedetomidine group and 26 recipients were placed in the haloperidol group...
May 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27309842/predictors-of-mortality-for-delirium-in-palliative-care
#14
Meera R Agar, Stephen J Quinn, Gregory B Crawford, Christine S Ritchie, Jane L Phillips, Aileen Collier, David C Currow
INTRODUCTION: Delirium has a high mortality rate. Understanding predictors of prognosis in patients with delirium will aid treatment decisions and communication. This study aimed to explore variables associated with death during an established episode of delirium in palliative care when haloperidol treatment had been commenced. METHODS: A consecutive cohort of palliative care patients, from 14 centers across four countries, is reported. The outcome of interest was death within 14 days from commencement of haloperidol treatment for delirium...
June 16, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27309161/what-to-do-when-haloperidol-fails-to-treat-agitated-delirium-is-dexmedetomidine-the-next-step
#15
Beth M T Teegarden, Donald S Prough
No abstract text is available yet for this article.
July 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27220943/bispectral-index-monitoring-in-terminally-ill-patients-a-validation-study
#16
Anniek D Masman, Monique van Dijk, Joost van Rosmalen, Heleen J Blussé van Oud-Alblas, Erwin Ista, Frans P M Baar, Dick Tibboel
CONTEXT: If regular therapies cannot relieve symptoms sufficiently in the last days of life, continuous palliative sedation may serve to reduce consciousness. Sedation level can be measured with EEG monitoring with the bispectral index (BIS) monitor. OBJECTIVES: To determine the feasibility and validity of BIS monitoring in terminally ill patients. METHODS: In this prospective study, BIS registrations were performed in unconscious end-of-life patients admitted to a palliative care center...
August 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27180238/sedation-at-the-end-of-life-a-nation-wide-study-in-palliative-care-units-in-austria
#17
Sophie Schur, Dietmar Weixler, Christoph Gabl, Gudrun Kreye, Rudolf Likar, Eva Katharina Masel, Michael Mayrhofer, Franz Reiner, Barbara Schmidmayr, Kathrin Kirchheiner, Herbert Hans Watzke
BACKGROUND: Sedation is used to an increasing extent in end-of-life care. Definitions and indications in this field are based on expert opinions and case series. Little is known about this practice at palliative care units in Austria. METHODS: Patients who died in Austrian palliative care units between June 2012 and June 2013 were identified. A predefined set of baseline characteristics and information on sedation during the last two weeks before death were obtained by reviewing the patients' charts...
2016: BMC Palliative Care
https://www.readbyqxmd.com/read/27123153/use-of-self-matching-to-control-for-stable-patient-characteristics-while-addressing-time-varying-confounding-on-treatment-effect-a-case-study-of-older-intensive-care-patients
#18
Ling Han, M A Pisani, K L B Araujo, Heather G Allore
Exposure-crossover design offers a non-experimental option to control for stable baseline confounding through self-matching while examining causal effect of an exposure on an acute outcome. This study extends this approach to longitudinal data with repeated measures of exposure and outcome using data from a cohort of 340 older medical patients in an intensive care unit (ICU). The analytic sample included 92 patients who received ≥1 dose of haloperidol, an antipsychotic medication often used for patients with delirium...
2016: International Journal of Statistics in Medical Research
https://www.readbyqxmd.com/read/27101233/assessment-of-pharmacological-treatment-quality-comparison-of-symptom-triggered-vs-fixed-schedule-alcohol-withdrawal-in-clinical-practice
#19
U J Müller, F Schuermann, H Dobrowolny, T Frodl, B Bogerts, S Mohr, J Steiner
Introduction: Despite the fact, that symptom-triggered alcohol withdrawal treatment is recommended by German guidelines on alcoholism, many hospitals continue to use fixed-schedule protocols, as they have been successfully applied for many years. Methods: This retrospective study compared all patients' records of alcohol withdrawal treatment from October 2010 to November 2011 at Magdeburg's University Department of Psychiatry (n=120). A symptom-triggered protocol with clomethiazole (AESB, n=46) was used in parallel with the existing fixed-schedule protocol with diazepam (n=74)...
September 2016: Pharmacopsychiatry
https://www.readbyqxmd.com/read/27073760/haloperidol-use-among-elderly-patients-undergoing-surgery-a-retrospective-1-year-study-in-a-hospital-population
#20
Harmke Nijboer, Geert Lefeber, Alidair McLullich, Barbara van Munster
BACKGROUND: Haloperidol, frequently used for delirium, can lead to serious side effects, of which QTc prolongation is the most worrisome since it is associated with an increased risk of fatal cardiac arrhythmia. OBJECTIVES: The aim of this study was to measure the frequency of haloperidol use after procedures in patients aged ≥65 years in a hospital in the Netherlands. METHODS: This was a retrospective study among patients hospitalized in the Netherlands who were aged ≥65 years and who underwent a procedure between January 2008 and January 2009...
2016: Drugs—Real World Outcomes
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