Hanqiang Deng, Elizabeth Min, Nicolas Baeyens, Brian G Coon, Rui Hu, Zhen W Zhuang, Minghao Chen, Billy Huang, Titilayo Afolabi, Georgia Zarkada, Angela Acheampong, Kathleen McEntee, Anne Eichmann, Fang Liu, Bing Su, Michael Simons, Martin A Schwartz
Endothelial cell (EC) sensing of wall fluid shear stress (FSS) from blood flow governs vessel remodeling to maintain FSS at a specific magnitude or set point in healthy vessels. Low FSS triggers inward remodeling to restore normal FSS but the regulatory mechanisms are unknown. In this paper, we describe the signaling network that governs inward artery remodeling. FSS induces Smad2/3 phosphorylation through the type I transforming growth factor (TGF)-β family receptor Alk5 and the transmembrane protein Neuropilin-1, which together increase sensitivity to circulating bone morphogenetic protein (BMP)-9...
September 14, 2021: Proceedings of the National Academy of Sciences of the United States of America