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https://www.readbyqxmd.com/read/29169228/control-of-type-o-foot-and-mouth-disease-by-vaccination-in-south-korea-2014-2015
#1
Jong-Hyeon Park, Dongseob Tark, Kwang-Nyeong Lee, Ji-Eun Chun, Hyang-Sim Lee, Young-Joon Ko, Soo-Jeong Kye, Yong-Joo Kim, Jae-Ku Oem, Soyoon Ryoo, Sung-Bin Lim, Seo-Yong Lee, Joo-Hyung Choi, Mi-Kyeong Ko, Su-Hwa You, Myoung-Heon Lee, Byounghan Kim
On December 3, 2014, a type O foot-and-mouth disease (FMD) outbreak occurred in South Korea. Although vaccinations were administered, cases of FMD increased steadily for five months and reached 185 cases by April 2015. Most of the affected animals were pigs, which are vulnerable to vaccinations. The FMD virus belonged to the South-East Asia (SEA) topotype that had been observed three times in Korea from April 2010 to July 2014. However, the virus in December 2014 had a unique difference in a partial deletion of the 5' noncoding region, which had not been seen in the previous SEA topotype isolates that were identified in Korea...
November 23, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29169149/prokaryotic-expression-and-anti-ibdv-activity-of-chicken-interleukin-18-and-interferon-%C3%AE
#2
Baifen Song, Xiaoting Li, Jinzhu Ma, Liquan Yu, Zhenyue Feng, Zhenhua Liu, Yudong Cui
Interferon-γ (IFN-γ), a cytokine produced by activated natural killer cells and T lymphocytes, is an important regulator of innate and adaptive immunity. Interleukin (IL)-18, also known as IFN-γ-inducing factor, is a cytokine that induces T and natural killer cells to produce IFN-γ. In this study, the chicken IL-18 (ChIL-18) and chicken IFN-γ (ChIFN-γ) genes were inserted into the pET28a prokaryotic expression vector, resulting in pET28a-IL-18 and pET28a-IFN-γ, respectively. These plasmids were transformed into Escherichia coli strain BL21, and the ChIL-18 and ChIFN-γ proteins were expressed and purified...
November 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29168889/acute-viral-infections-of-the-central-nervous-system-2014-2016-greece
#3
Anna Papa, Elpida Papadopoulou
In order to investigate the viral etiology of acute infections of central nervous system (CNS), multiplex and single PCRs combined with serology for arboviruses were applied on samples from 132 hospitalized patients in Greece during May 2014 to December 2016. A viral pathogen was detected in 52 of 132 (39.4%) cases with acute CNS infection. Enteroviruses predominated (15/52, 28.8%), followed by West Nile virus (9/52, 17.3%). Phleboviruses, varicella-zoster virus and Epstein-Barr virus accounted for 15.4%, 13...
November 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29168888/apparent-seronegative-maternal-shingles-with-post-natal-mother-to-baby-transmission-of-varicella-zoster-virus
#4
Lin Pan, Nitesh Singh, Ruth Cannon, Joe Fawke, Julian W Tang
We present an unusual case of varicella zoster (VZ) virus IgG negative, yet clinically apparent, maternal shingles, which prompted the administration of VZ immunoglobulin to the newborn. The mother had no previous VZ vaccination. Eleven days later the baby developed a primary VZ infection, with only mild disease, likely as a result of the VZ immunoglobulin. The variable sensitivity of VZV IgG-specific assays is well-recognised. Thus, the ability of this particular VZV IgG assay to detect both maternal and infant VZV IgG, post-natally, suggests that the earlier VZV IgG negative results were due to lower circulating levels of maternal antibody...
November 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29168767/long-non-coding-rnas-in-hepatitis-b-virus-related-hepatocellular-carcinoma-regulation-functions-and-underlying-mechanisms
#5
REVIEW
Lipeng Qiu, Tao Wang, Xiuquan Xu, Yihang Wu, Qi Tang, Keping Chen
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death in the world. Hepatitis B virus (HBV) and its X gene-encoded protein (HBx) play important roles in the progression of HCC. Although long non-coding RNAs (lncRNAs) cannot encode proteins, growing evidence indicates that they play essential roles in HCC progression, and contribute to cell proliferation, invasion and metastasis, autophagy, and apoptosis by targeting a large number of pivotal protein-coding genes, miRNAs, and signaling pathways...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168754/a-bioinformatic-pipeline-for-monitoring-of-the-mutational-stability-of-viral-drug-targets-with-deep-sequencing-technology
#6
Yuri Kravatsky, Vladimir Chechetkin, Daria Fedoseeva, Maria Gorbacheva, Galina Kravatskaya, Olga Kretova, Nickolai Tchurikov
The efficient development of antiviral drugs, including efficient antiviral small interfering RNAs (siRNAs), requires continuous monitoring of the strict correspondence between a drug and the related highly variable viral DNA/RNA target(s). Deep sequencing is able to provide an assessment of both the general target conservation and the frequency of particular mutations in the different target sites. The aim of this study was to develop a reliable bioinformatic pipeline for the analysis of millions of short, deep sequencing reads corresponding to selected highly variable viral sequences that are drug target(s)...
November 23, 2017: Viruses
https://www.readbyqxmd.com/read/29168732/viral-infection-and-apoptosis
#7
EDITORIAL
Marc Kvansakul
Viruses are master molecular manipulators, and evolved to thrive and survive in all species.[...].
November 23, 2017: Viruses
https://www.readbyqxmd.com/read/29168728/interference-of-htlv-1-tax-protein-with-cell-polarity-regulators-defining-the-subcellular-localization-of-the-tax-dlg1-interaction
#8
Federico Marziali, Marina Bugnon Valdano, Clarisse Brunet Avalos, Lucía Moriena, Ana Laura Cavatorta, Daniela Gardiol
Human T cell leukemia virus (HTLV)-1 Tax (Tax) protein is very important in viral replication and cell transformation. Tax localizes in the nucleus and cytoplasm in association with organelles. Some activities of Tax depend on interactions with PDZ (PSD-95/Discs Large/Z0-1) domain-containing proteins such as Discs large protein 1 (DLG1) which is involved in cell polarity and proliferation. The DLG1 interaction results in a cytoplasmic co-localization pattern resembling vesicular aggregates, the nature of which is still unknown...
November 23, 2017: Viruses
https://www.readbyqxmd.com/read/29168676/molecular-and-phylogenetic-analyses-of-influenza-b-viruses-isolated-from-pediatric-inpatients-in-south-korea-during-the-2011-2012-winter-season
#9
Jeong-Hyun Nam, Eun-Jung Song, Daesub Song, Erica Españo, Sang-Mu Shim, Seo-Hee Jeong, Robert G Webster, Woo-Joo Kim, Jeong-Ki Kim
Influenza B virus remains a major cause of respiratory diseases worldwide. Because of limited epidemiological and genetic data, the local and global transmission patterns of influenza B virus are not fully understood. Here we report the molecular and phylogenetic characterization of 163 influenza B virus isolates from pediatric inpatients with influenza-like illness in the winter of 2011-2012 in South Korea. Analysis of haemagglutinin and neuraminidase genes of the influenza B isolates revealed that both B/Victoria (62 %) and B/Yamagata lineages (38 %) co-circulated during that influenza season, and a considerable number of the isolates carried several amino acid substitutions in the four major antigenic epitopes of their haemagglutinin protein...
November 23, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29168646/anal-cytology-histopathology-and-anoscopy-in-an-anal-dysplasia-screening-program-is-anal-cytology-enough
#10
Marco Silva, Armando Peixoto, José Alexandre Sarmento, Rosa Coelho, Guilherme Macedo
BACKGROUND AND AIM: The human papilloma virus is the leading cause of anal squamous cell carcinoma. Cytological screening may reduce the associated morbidity and mortality. The aim of the study was to estimate the agreement between anal cytological examination, histopathology and anoscopic visual impression. METHODS: A prospective study of patients who underwent anal dysplasia screening between 2011 and 2015, in a proctology clinic of a tertiary referral center...
November 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29168582/diagnostic-value-of-trait-antinuclear-antibodies-and-multiple-immunoglobulin-production-in-autoimmune-diseases
#11
Liping Wan, Hong Zhu, Yanan Gu, Hui Liu
BACKGROUND: Our article aims to evaluate the proportion of monospecific antinuclear antibodies (ANA) and polyclonal ANAs in patients with autoimmune diseases based on the results of an ANA panel and to evaluate the efficiency of trait ANAs as a novel diagnostic tool. This study also aims to investigate immunoglobulin production in autoimmune diseases by detecting different antibodies. METHODS: The serum ANA profile of 634 patients with autoimmune diseases was analyzed using the immunoblot method...
November 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29168457/newer-direct-acting-antivirals-for-hepatitis-c-virus-infection-perspectives-for-india
#12
REVIEW
Varun Gupta, Ashish Kumar, Praveen Sharma, Anil Arora
Approximately three per cent of the world's population (170-200 million people) is chronically infected with hepatitis C virus (HCV) and almost 500,000 people die each year (mostly in lower middle-income countries) from complications secondary to HCV infection. In India, HCV infection imposes a considerable burden of mortality, morbidity and healthcare costs. In the last two decades, the treatment of HCV has evolved from interferon (IFN)-based therapies with or without ribavirin (RBV) to pegylated-IFN (PEG-IFN) and RBV-based therapies that were better tolerated by patients...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168452/third-trimester-tenofovir-to-prevent-mother-to-child-hepatitis-b-virus-transmission
#13
EDITORIAL
Blaire E Burman, Manan A Jhaveri, Kris V Kowdley
No abstract text is available yet for this article.
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168447/a-brief-summary-of-the-epidemiology-and-genetic-relatedness-of-avian-influenza-h9n2-virus-in-birds-and-mammals-in-the-middle-east-and-north-africa
#14
A Nagy, T C Mettenleiter, E M Abdelwhab
H9N2 is the most widespread avian influenza virus subtype in poultry worldwide. It infects a broad spectrum of host species including birds and mammals. Infections in poultry and humans vary from silent to fatal. Importantly, all AIV, which are fatal in humans (e.g. H5N1, H7N9) acquired their 'internal' gene segments from H9N2 viruses. Although H9N2 is endemic in the Middle East (ME) and North Africa since the late 1990s, little is known about its epidemiology and genetics on a regional level. In this review, we summarised the epidemiological situation of H9N2 in poultry and mammals in Iran, Iraq, Kuwait, Qatar, United Arab Emirates, Oman, Bahrain, Yemen, Saudi Arabia, Jordan, Palestine, Israel, Syria, Lebanon, Turkey, Egypt, Sudan, Libya, Tunisia, Algeria and Morocco...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29168445/strengthened-ebola-surveillance-in-france-during-a-major-outbreak-in-west-africa-march-2014-january-2016
#15
A Mailles, H Noel, D Pannetier, C Rapp, Y Yazdanpanah, S Vandentorren, P Chaud, J M Philippe, B Worms, M Bruyand, M Tourdjman, M Nahon, E Belchior, E Lucas, J Durand, M Zurbaran, S Vaux, B Coignard, H DE Valk, S Baize, S Quelet, F Bourdillon
Introduction An unprecedented outbreak of Ebola virus diseases (EVD) occurred in West Africa from March 2014 to January 2016. The French Institute for Public Health implemented strengthened surveillance to early identify any imported case and avoid secondary cases. METHODS: Febrile travellers returning from an affected country had to report to the national emergency healthcare hotline. Patients reporting at-risk exposures and fever during the 21st following day from the last at-risk exposure were defined as possible cases, hospitalised in isolation and tested by real-time polymerase chain reaction...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29168441/detection-of-hev-specific-antibodies-in-four-non-human-primate-species-including-great-apes-from-different-zoos-in-germany
#16
C Spahr, T Knauf-Witzens, L Dähnert, M Enders, M Müller, R Johne, R G Ulrich
The hepatitis E virus (HEV) has been described in humans and various animal species in different regions of the world. However, the knowledge on natural HEV infection in non-human primates and the corresponding risk of zoonotic transmission is scarce. To determine whether primates in captivity are affected by HEV infection, we investigated 259 individual sera of clinically healthy non-human primates of 14 species from nine German zoos. Using a commercial double-antigen-sandwich ELISA and a commercial IgG ELISA, 10 animals (3·9%) reacted positive in at least one assay...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29168317/hepatitis-c-virus-prevalence-and-associated-risk-factors-among-indigenous-australians-who-inject-drugs
#17
Michael Doyle, Lisa Maher, Simon Graham, Handan Wand, Jenny Iversen
OBJECTIVE: To examine factors associated with hepatitis C virus (HCV) infection among a national sample of Indigenous and non-Indigenous people who inject drugs (PWID) in Australia. METHODS: Respondents were recruited from Australia's Needle Syringe Program Survey; an annual bio-behavioural surveillance project that monitors HCV antibody prevalence among PWID. Data from 2006-2015 were de-duplicated to retain only one record where individuals participated in >1 survey round...
November 22, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29168214/transdermal-light-neuromodulation-optogenetics-in-the-murine-urinary-tract
#18
Shannon L Wallace, Robert S Kelley, Shailja Mehta, Giannina Descalzi, John A Fantl, Charles Ascher-Walsh
BACKGROUND: Optogenetics is a biologic technique that uses light to control living neurons, which have been genetically modified to express light-sensitive ion-channels. OBJECTIVES: Using an adenovirus to modify the sciatic nerves of mice, we aim to demonstrate peripheral neuromodulation of bladder pain using transdermal light. STUDY DESIGN: This pilot study is divided into: A) Confirmation and Application and B) Behavioral Step. A) Six mice were injected with AAV6-hSyn-ChR2(H134R)-eYFP virus into their sciatic nerves...
November 23, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29168145/erratum-to-purification-of-cyclic-gmp-amp-from-viruses-and-measurement-of-its-activity-in-cell-culture
#19
Alice Mayer, Jonathan Maelfait, Anne Bridgeman, Jan Rehwinkel
No abstract text is available yet for this article.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29168031/neural-cells-generated-from-human-induced-pluripotent-stem-cells-as-a-model-of-cns-involvement-in-mucopolysaccharidosis-type-ii
#20
Jitka Rybová, Jana Ledvinová, Jakub Sikora, Ladislav Kuchař, Robert Dobrovolný
Mucopolysaccharidosis type II (MPSII) is a rare X-linked lysosomal storage disorder caused by mutations in the iduronate-2-sulfatase (IDS) gene (IDS, Xq28). MPSII is characterized by skeletal deformities, hearing loss, airway obstruction, hepatosplenomegaly, cardiac valvular disease, and progressive neurological impairment. At the cellular level, IDS deficiency leads to lysosomal storage of glycosaminoglycans (GAGs), dominated by accumulation of dermatan and heparan sulfates. Human induced pluripotent stem cells (iPSC) represent an alternative system that complements the available MPSII murine model...
November 22, 2017: Journal of Inherited Metabolic Disease
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