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https://www.readbyqxmd.com/read/29285277/indirubin-a-bisindole-alkaloid-from-isatis-indigotica-reduces-h1n1-susceptibility-in-stressed-mice-by-regulating-mavs-signaling
#1
Chong Jie, Zhuo Luo, Huan Chen, Min Wang, Chang Yan, Zhong-Fu Mao, Gao-Keng Xiao, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He
Isatis indigotica has a long history in treating virus infection and related symptoms in China. Nevertheless, its antivirus evidence in animal studies is not satisfactory, which might be due to the lack of appropriate animal model. Previously, we had utilized restraint stress to establish mouse H1N1 susceptibility model which was helpful in evaluating the anti-virus effect of medicines targeting host factors, such as type I interferon production. In this study, this model was employed to investigate the effect and mechanism of indirubin, a natural bisindole alkaloid from Isatis indigotica, on influenza A virus susceptibility...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29235279/-advance-of-a-representative-traditional-tibetan-medicine-meconopsis-horridula-on-its-phytochemical-and-pharmacological-aspects
#2
REVIEW
Feng Zhao, He-Xin-Ge Zhang, Rui-Feng Bai, Bing-Zhao Tu, Xiao-Li Gao, Peng-Fei Tu, Xing-Yun Chai
Meconopsis horridula is one of alpine plants belonging to family Papaveraceae, mainly distributed in Himalaya Range area. M. horridula is a rare alpine flower, and is a kind of traditional Tibetan medicine, which has been included in more than 40 compound formulae, having efficacies of clearing away heat and alleviating pain, activating blood circulation to remove stasis, traditionally used for the treatment of fractures, injuries, and chest and back pains. Modern research shows that the whole plant of M. horridula contains alkaloids, flavonoids, and terpenes, and its pharmacological activities including antitumor, antivirus and myocardial protection etc...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29168290/gating-the-holes-in-the-swiss-cheese-part-i-expanding-professor-reason-s-model-for-patient-safety
#3
Shashi S Seshia, G Bryan Young, Michael Makhinson, Preston A Smith, Kent Stobart, Pat Croskerry
INTRODUCTION: Although patient safety has improved steadily, harm remains a substantial global challenge. Additionally, safety needs to be ensured not only in hospitals but also across the continuum of care. Better understanding of the complex cognitive factors influencing health care-related decisions and organizational cultures could lead to more rational approaches, and thereby to further improvement. HYPOTHESIS: A model integrating the concepts underlying Reason's Swiss cheese theory and the cognitive-affective biases plus cascade could advance the understanding of cognitive-affective processes that underlie decisions and organizational cultures across the continuum of care...
November 23, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29163506/the-significance-of-type-i-interferons-in-the-pathogenesis-and-therapy-of-human-immunodeficiency-virus-1-infection
#4
REVIEW
Bowen Wang, Wen Kang, Jiahui Zuo, Wenzhen Kang, Yongtao Sun
Type-I interferons (IFN-I) are a widely expressed family that could promote antivirus immunity in the process of pathogens invasion. In a human immunodeficiency virus 1 (HIV-1)-infected individual, the production of IFN-I can be detected as early as the acute phase and will persist throughout the course of infection. However, sustained stimulation of immune system by IFN-I also contributes greatly to host-mediated immunopathology and diseases progression. Although the protective effects of IFN-I in the acute phase of HIV-1 infection have been observed, more studies recently focus on their detrimental role in the chronic stage...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29138799/lychee-seed-extract-protects-against-neuronal-injury-and-improves-cognitive-function-in-rats-with-type-ii-diabetes-mellitus-with-cognitive-impairment
#5
Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qin
Lychee seed is a traditional Chinese medicine and has many beneficial effects such as modulation of blood sugar and lipids, antioxidation, antivirus and antitumor. Studies have indicated that type II diabetes mellitus (T2DM) and Alzheimer's disease (AD) share common biological mechanisms including insulin resistance, impaired glucose metabolism, β‑amyloid (Aβ) formation, oxidative stress and presence of advanced glycation end products (AGEs). The present study investigated the effects of lychee seed extract (LSE) on neuroprotection, cognitive function improvement and possible underlying mechanisms in a rat model of T2DM with cognitive impairment...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29121070/identification-and-characterization-of-intestine-micrornas-and-targets-in-red-swamp-crayfish-procambarus-clarkii-infected-with-white-spot-syndrome-virus
#6
Zhi-Qiang Du, Kai Wang, Xiu-Li Shen, Yan-Hui Jin, Hai-Xia Jin, Xin-Cang Li
MicroRNAs (miRNAs) are small non-coding endogenous RNA molecules that play important roles in the innate immunity system of invertebrates, especially in the aspect of antivirus. In the present study, high-throughput small RNA Illumina sequencing systems were used to identify differentially expressed miRNAs (DEMs) from the intestines of Procambarus clarkii that were infected with white spot syndrome virus (WSSV). As a result, 39 known and 12 novel miRNAs were identified in both NG and WG small RNA libraries...
2017: PloS One
https://www.readbyqxmd.com/read/29117742/dereplication-and-targeted-isolation-of-bioactive-sulphur-compound-from-bacteria-isolated-from-a-hydrothermal-field
#7
Xiuping Lin, Kunlong Li, Lilin Yang, Xiaoying Peng, Wei Fang, Xinpeng Tian, Yonghong Liu, Xuefeng Zhou
Marine micro-organisms in the deep-sea hydrothermal vent systems are considered as potential sources of bioactive natural products. Sixteen bacterial strains were isolated from a deep-sea hydrothermal field and screened for bioactive metabolism studies. After the strains were subjected to bioactive testing at different culture media, chemical dereplication by HPLC coupled to high-resolution mass spectrometer was performed to analyse or determine the main secondary metabolisms in those strains. Strain 06204 was large-scale fermented with relative optimal media, for isolating the desired sulphur compound...
November 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29115429/resveratrol-mediated-apoptosis-in-renal-cell-carcinoma-via-the-p53-amp%C3%A2-activated-protein-kinase-mammalian-target-of-rapamycin-autophagy-signaling-pathway
#8
Qingjun Liu, Qiang Fang, Shiqi Ji, Zhixing Han, Wenlong Cheng, Haijian Zhang
Resveratrol, known as phytoalexin, is a natural compound. Clinical studies have revealed that resveratrol has a variety of effects including anti‑inflammatory, antivirus and tumor suppressor activities. It has been reported that it may serve an important role in renal cell carcinoma (RCC) however, the molecular mechanism underlying resveratrol‑induced apoptosis in RCC is still unclear. The aim of the present study was to determine whether resveratrol could suppress RCC progression. Analysis of apoptosis demonstrated that resveratrol may act as a RCC suppressor in a dose‑ and time‑dependent manner...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29051711/down-regulation-of-ifitm1-and-its-growth-inhibitory-role-in-cervical-squamous-cell-carcinoma
#9
Weinan Zheng, Zhimin Zhao, Xinan Yi, Qiangqiang Zuo, Hongtao Li, Xiaoqing Guo, Dongmei Li, Hongchang He, Zemin Pan, Peiwen Fan, Feng Li, Yanhong Liao, Renfu Shao
BACKGROUND: Cervical cancer is a major cause of death in women worldwide. Interferon-induced transmembrane protein 1 (IFITM1) is involved in antivirus defense, cell adhesion, and carcinogenesis in different tissues. However, the role of IFITM1 gene in cervical squamous cell cancer is unclear. METHODS: To explore the role of IFITM1 in carcinogenesis of cervical cancer, we investigated the expression of IFITM1 gene in cervical squamous cell carcinoma. IFITM1 mRNA level was measured by real-time quantitative RT-PCR in cervical cancer tissues and their adjacent normal tissues...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29040028/elaboration-in-type-primary-structure-and-bioactivity-of-polysaccharides-derived-from-mollusks
#10
Ling Chong Wang, Liu Qing Di, Jun Song Li, Li Hong Hu, Jian Ming Cheng, Hao Wu
Over the past decades, numerous Mollusca species have received more attention in development and utilization as valuable bio-resources. Many efforts have been focused on investigating mollusk polysaccharides because of their rich content, ease of extraction, diversified sorts, specific structure, various biofunctions and potent activities. To date, many mollusks, especially species of gastropods, bivalves, or cephalopods, have been reported containing polysaccharide compounds in tissues with abundant amount, and most of polysaccharides are obtainable through combining techniques of extraction, separation and purification...
October 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28914420/labdane-type-diterpenoids-from-vitex-limonifolia-and-their-antivirus-activities
#11
Ninh Khac Ban, Nguyen Thi Kim Thoa, Tran My Linh, Do Thi Trang, Phan Van Kiem, Nguyen Xuan Nhiem, Bui Huu Tai, Chau Van Minh, Jae-Hyoung Song, Hyun-Jeong Ko, Seung Hyun Kim
Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods...
September 15, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28840680/-pharmacological-effect-and-toxicology-of-sophorae-tonkinensis-radix-et-rhizoma
#12
REVIEW
Ying Chen, Liang-Mian Chen, Yan Tong, Yun You
Sophorae Tonkinensis Radix et Rhizoma, which has been commonly used in clinic, shows activities in antitumor, antivirus, antibacteria, analgesia, anti-inflammation, anti-liver injury, anti-oxidation and immune enhancement, but can cause liver toxicity, neurotoxicity, gastrointestinal toxicity and respiratory toxicity. Its pharmacological effect and toxicity are related to extraction process, dosage and administration time. Therefore, exploration of appropriate extraction process, toxicity-effect dosage range, toxic substance basis provides guarantee for attenuation and safe clinical medication...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28803958/identification-and-characterization-of-lymph-organ-micrornas-in-red-swamp-crayfish-procambarus-clarkii-infected-with-white-spot-syndrome-virus
#13
Zhi-Qiang Du, Xiao-Yun Leng, Xiu-Li Shen, Yan-Hui Jin, Xin-Cang Li
MicroRNAs (miRNAs) were important post-transcriptional regulators and played vital roles in innate immunity system of invertebrates, especially in the aspect of antivirus. In this study, using high-throughput small RNAs Illumina sequencing system, differentially expressed miRNAs (DEMs) from lymph organs in red swamp crayfish, Procambarus clarkii, infected with white spot syndrome virus, were identified. As a result, 32 known miRNAs and 7 novel miRNAs were identified in crayfish lymph organ small RNAs library of NG and WG...
August 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28676001/antitumor-activity-of-polysaccharides-an-overview
#14
Ling Chen, Gangliang Huang
BACKGROUND: Polysaccharides are widely found in animals, plants and micro- organisms, and are closely related to various physiological functions. It is one of the four basic substances that constitute life activities. Polysaccharide has antitumor, antivirus, antioxidant, immune regulation and other biological activities. OBJECTIVE: Because the polysaccharide has significant antitumor effect and small side-effects, it has become the focus of the current antitumor drug research...
July 4, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28672161/polintons-virophages-and-transpovirons-a-tangled-web-linking-viruses-transposons-and-immunity
#15
REVIEW
Eugene V Koonin, Mart Krupovic
Virophages are satellite DNA viruses that depend for their replication on giant viruses of the family Mimiviridae. An evolutionary relationship exists between the virophages and Polintons, large self-synthesizing transposons that are wide spread in the genomes of diverse eukaryotes. Most of the Polintons encode homologs of major and minor icosahedral virus capsid proteins and accordingly are predicted to form virions. Additionally, metagenome analysis has led to the discovery of an expansive family of Polinton-like viruses (PLV) that are more distantly related to bona fide Polintons and virophages...
August 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28657148/association-between-mitochondrial-dna-content-and-baseline-serum-levels-of-hbsag-in-chronic-hepatitis-b-infection
#16
Tianbin Chen, Zhen Xun, Jinpiao Lin, Ya Fu, Wennan Wu, Xiaochun Fu, Yuhai Hu, Yongbin Zeng, Qishui Ou
Recent studies have demonstrated a potential link between mitochondrial DNA (mtDNA) content and cirrhosis or hepatocellular carcinoma (HCC). However, there are few studies evaluating mtDNA content as a noninvasive marker of chronic hepatitis B infection (CHB). In this study, we conducted a case-control study to determine mtDNA content in peripheral blood leukocyte (PBL) samples from 76 CHB cases naïve to antivirus therapy and 96 healthy controls, and then evaluated the association between mtDNA content and baseline serum concentration of HBV markers...
November 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28653889/bioinformatics-methods-for-identifying-differentially-expressed-genes-and-signaling-pathways-in-nano-silica-stimulated-macrophages
#17
Lin Zhang, Changfu Hao, Juan Li, Yaqian Qu, Lei Bao, Yiping Li, Zhongzheng Yue, Miao Zhang, Xinghao Yu, Huiting Chen, Jianhui Zhang, Di Wang, Wu Yao
The incidence of disease relating to nanoparticle exposure has been rising rapidly in recent years, for which there is no effective treatment. Macrophage is suggested to play a crucial role in the development of pulmonary disease. To investigate the changes in macrophage after being stimulated by nanometer silica dust and to explore potential biomarkers and signaling pathways, the gene chip GSE13005 was downloaded from Gene Expression Omnibus database, which contained 21 samples: 3 samples per group and 7 groups in total...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28634719/a-sugarcane-pathogenesis-related-protein-scpr10-plays-a-positive-role-in-defense-responses-under-sporisorium-scitamineum-srmv-sa-and-meja-stresses
#18
Qiong Peng, Yachun Su, Hui Ling, Waqar Ahmad, Shiwu Gao, Jinlong Guo, Youxiong Que, Liping Xu
A pathogenesis-related gene, ScPR10 , was isolated from sugarcane and its bio-function was characterized, demonstrating that ScPR10 was involved in plant defense responses to Sporisorium scitamineum , SrMV, SA, and MeJA stresses. Plant fungal and viral diseases are the major concerns in sugarcane industry. Many anti-fungal and antivirus components, including pathogenesis-related (PR) proteins, have been identified. The pathogenesis-related protein 10 (PR10) is the dominant group in PR families, involved in the plant defense mechanism...
June 20, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28571917/targeting-mir-21-with-sophocarpine-inhibits-tumor-progression-and-reverses-epithelial-mesenchymal-transition-in-head-and-neck-cancer
#19
Wei Liu, Beilei Zhang, Guo Chen, Wenjiao Wu, Lin Zhou, Yaru Shi, Qi Zeng, Yanqiu Li, Youwei Sun, Xingming Deng, Fu Wang
A major challenge for cancer chemotherapy is the development of safe and clinically effective chemotherapeutic agents. With its low toxicity profile, sophocarpine (SC), a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities. However, the antitumor efficacy of SC and its underlying mechanisms have not been completely delineated. In the present study, the inhibitory effect of SC on head and neck squamous cell carcinoma (HNSCC) progression and possible mechanisms for this effect involving microRNA-21 (miR-21) regulation were investigated...
September 6, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28545555/the-complex-domain-architecture-of-samd9-family-proteins-predicted-stand-like-ntpases-suggests-new-links-to-inflammation-and-apoptosis
#20
Sergei L Mekhedov, Kira S Makarova, Eugene V Koonin
We report a comprehensive computational dissection of the domain architecture of the SAMD9 family proteins that are involved in antivirus and antitumor response in humans. We show that the SAMD9 protein family is represented in most animals and also, unexpectedly, in bacteria, in particular actinomycetes. From the N to C terminus, the core SAMD9 family architecture includes DNA/RNA-binding AlbA domain, a variant Sir2-like domain, a STAND-like P-loop NTPase, an array of TPR repeats and an OB-fold domain with predicted RNA-binding properties...
May 25, 2017: Biology Direct
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