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JOURNAL ARTICLE
Shannon B Leland, Steven J Staffa, Margaret M Newhams, Robinder G Khemani, John C Marshall, Cameron C Young, Aline B Maddux, Mark W Hall, Scott L Weiss, Adam J Schwarz, Bria M Coates, Ronald C Sanders, Michele Kong, Neal J Thomas, Ryan A Nofziger, Melissa L Cullimore, Natasha B Halasa, Laura L Loftis, Natalie Z Cvijanovich, Jennifer E Schuster, Heidi Flori, Shira J Gertz, Janet R Hume, Samantha M Olson, Manish M Patel, David Zurakowski, Adrienne G Randolph
OBJECTIVES: To develop, evaluate, and explore the use of a pediatric ordinal score as a potential clinical trial outcome metric in children hospitalized with acute hypoxic respiratory failure caused by viral respiratory infections. DESIGN: We modified the World Health Organization Clinical Progression Scale for pediatric patients (CPS-Ped) and assigned CPS-Ped at admission, days 2-4, 7, and 14. We identified predictors of clinical improvement (day 14 CPS-Ped ≤ 2 or a three-point decrease) using competing risks regression and compared clinical improvement to hospital length of stay (LOS) and ventilator-free days...
August 4, 2023: Pediatric Critical Care Medicine
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JOURNAL ARTICLE
Teresa Hickam, Michele H Maddux, Ann Modrcin, Patience White
PURPOSE: Without a structured health-care transition (HCT) process, youths with chronic conditions face increased morbidity, care gaps, and dissatisfaction. This article documents the process and outcomes of implementing a standardized approach in a large children's hospital. METHODS: Children's Mercy Kansas City adopted Got Transition's Six Core Elements of Health Care Transition and established a system-wide implementation plan, between 2015 and 2019, involving leadership buy-in, consumer engagement, infrastructure improvements, and quality improvement efforts...
August 2, 2023: Journal of Adolescent Health
#23
REVIEW
Donald R Brake, Reena N Yaman, Alyssa R Camargo, Lisa A Marks, Jacob T Maddux, Sergei I Ochkur, Matthew A Rank
Background: Pollen is a key source of aeroallergens responsible for allergic rhinitis, conjunctivitis, and asthma. Objective: The goal of this scoping review was to summarize current available literature on the factors that affect pollen counts, allergenicity, and thresholds that induce symptoms in individuals who were sensitized. Methods: Several databases showed no published articles with a similar scope as of January 2022. A search of these data bases yielded 373 articles for assessment. These were then reviewed for relevance, and articles were selected to demonstrate the breadth of available data on pollen counts, allergenicity, and thresholds that induce symptoms in individuals who were sensitized...
July 1, 2023: Allergy and Asthma Proceedings:
#24
JOURNAL ARTICLE
Caitlin K Rollins, Johanna Calderon, David Wypij, Alex M Taylor, Tahera Sultana Davalji Kanjiker, Julia S Rohde, Moshe Maiman, Laura D Zambrano, Margaret M Newhams, Susan Rodriguez, Nicholas Hart, Jennifer Worhach, Suden Kucukak, Tina Y Poussaint, Mary Beth F Son, Matthew L Friedman, Shira J Gertz, Charlotte V Hobbs, Michele Kong, Aline B Maddux, Jennifer L McGuire, Paul A Licht, Mary Allen Staat, Lael M Yonker, Maitreyi Mazumdar, Adrienne G Randolph, Angela P Campbell, Jane W Newburger
IMPORTANCE: Acute neurological involvement occurs in some patients with multisystem inflammatory syndrome in children (MIS-C), but few data report neurological and psychological sequelae, and no investigations include direct assessments of cognitive function 6 to 12 months after discharge. OBJECTIVE: To characterize neurological, psychological, and quality of life sequelae after MIS-C. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional cohort study was conducted in the US and Canada...
July 3, 2023: JAMA Network Open
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JOURNAL ARTICLE
Ericka L Fink, Patrick M Kochanek, Sue R Beers, Robert R S B Clark, Rachel P Berger, Hülya Bayir, Alexis A Topjian, Christopher Newth, Craig Press, Aline B Maddux, Frederick Willyerd, Elizabeth A Hunt, Ashley Siems, Melissa G Chung, Lincoln Smith, Leslie Doughty, J Wesley Diddle, Jason Patregnani, Juan Piantino, Karen Hallermeier Walson, Binod Balakrishnan, Michael T Meyer, Stuart Friess, Jose Pineda, David Maloney, Pamela Rubin, Tamara L Haller, Amery Treble-Barna, Chunyan Wang, Vince Lee, Jessica L Wisnowski, Subramanian Subramanian, Srikala Narayanan, Stefan Blüml, Anthony Fabio, Ashok Panigrahy
IMPORTANCE: Morbidity and mortality after pediatric cardiac arrest are chiefly due to hypoxic-ischemic brain injury. Brain features seen on magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) after arrest may identify injury and aid in outcome assessments. OBJECTIVE: To analyze the association of brain lesions seen on T2-weighted MRI and diffusion-weighted imaging and N-acetylaspartate (NAA) and lactate concentrations seen on MRS with 1-year outcomes after pediatric cardiac arrest...
June 1, 2023: JAMA Network Open
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JOURNAL ARTICLE
Erin K Stenson, Russell K Banks, Ron W Reeder, Aline B Maddux, Jerry Zimmerman, Kathleen L Meert, Peter M Mourani
OBJECTIVES: To evaluate the association between fluid balance (FB) and health-related quality of life (HRQL) among children at 1 month following community-acquired septic shock. DESIGN: Nonprespecified secondary analysis of the Life After Pediatric Sepsis Evaluation. FB was defined as 100 × [(cumulative PICU fluid input - cumulative PICU fluid output)/PICU admission weight]. Three subgroups were identified: low FB (< 5%), medium FB (5%-15%), and high FB (> 15%) based on cumulative FB on days 0-3 of ICU stay...
June 1, 2023: Pediatric Critical Care Medicine
#27
JOURNAL ARTICLE
Richard V Remigio, Hyeonjin Song, Jochen G Raimann, Peter Kotanko, Frank W Maddux, Rachel A Lasky, Xin He, Amir Sapkota
BACKGROUND: Nonadherence to hemodialysis appointments could potentially result in health complications that can influence morbidity and mortality. We examined the association between different types of inclement weather and hemodialysis appointment adherence. METHODS: We analyzed health records of 60,135 patients with kidney failure who received in-center hemodialysis treatment at Fresenius Kidney Care clinics across the Northeastern US counties during 2001-2019...
April 18, 2023: Clinical Journal of the American Society of Nephrology: CJASN
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JOURNAL ARTICLE
Hanjie Zhang, Lin-Chun Wang, Sheetal Chaudhuri, Aaron Pickering, Len Usvyat, John Larkin, Pete Waguespack, Zuwen Kuang, Jeroen P Kooman, Franklin W Maddux, Peter Kotanko
BACKGROUND: In maintenance hemodialysis patients, intradialytic hypotension (IDH) is a frequent complication that has been associated with poor clinical outcomes. Prediction of IDH may facilitate timely interventions and eventually reduce IDH rates. METHODS: We developed a machine learning model to predict IDH in in-center hemodialysis patients 15 to 75 minutes in advance. IDH was defined as systolic blood pressure (SBP) < 90 mmHg. Demographic, clinical, treatment-related, and laboratory data were retrieved from electronic health records and merged with intradialytic machine data that were sent in real-time to the cloud...
April 13, 2023: Nephrology, Dialysis, Transplantation
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JOURNAL ARTICLE
Eran Mick, Alexandra Tsitsiklis, Jack Kamm, Katrina L Kalantar, Saharai Caldera, Amy Lyden, Michelle Tan, Angela M Detweiler, Norma Neff, Christina M Osborne, Kayla M Williamson, Victoria Soesanto, Matthew Leroue, Aline B Maddux, Eric Af Simões, Todd C Carpenter, Brandie D Wagner, Joseph L DeRisi, Lilliam Ambroggio, Peter M Mourani, Charles R Langelier
BACKGROUNDLower respiratory tract infection (LRTI) is a leading cause of death in children worldwide. LRTI diagnosis is challenging because noninfectious respiratory illnesses appear clinically similar and because existing microbiologic tests are often falsely negative or detect incidentally carried microbes, resulting in antimicrobial overuse and adverse outcomes. Lower airway metagenomics has the potential to detect host and microbial signatures of LRTI. Whether it can be applied at scale and in a pediatric population to enable improved diagnosis and treatment remains unclear...
April 3, 2023: Journal of Clinical Investigation
#30
REVIEW
Volodymyr Novakivskyy, Roman Shurduk, Inna Grin, Taisiia Tkachenko, Nataliia Pavlenko, Anastasiia Hrynevych, Jeffrey L Hymes, Franklin W Maddux, Stefano Stuard
In January 2021, there were 9648 patients in Ukraine on kidney replacement therapy, including 8717 on extracorporeal therapies and 931 on peritoneal dialysis. On 24 February 2022, foreign troops entered the territory of Ukraine. Before the war, the Fresenius Medical Care dialysis network in Ukraine operated three medical centres. These medical centres provided haemodialysis therapy to 349 end-stage kidney disease patients. In addition, Fresenius Medical Care Ukraine delivered medical supplies to almost all regions of Ukraine...
April 2023: Clinical Kidney Journal
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JOURNAL ARTICLE
Jean-Bernard Lubin, Jamal Green, Sarah Maddux, Lidiya Denu, Tereza Duranova, Matthew Lanza, Meghan Wynosky-Dolfi, Julia N Flores, Logan P Grimes, Igor E Brodsky, Paul J Planet, Michael A Silverman
Disruptions to the intestinal microbiome during weaning lead to negative effects on host immune function. However, the critical host-microbe interactions during weaning that are required for immune system development remain poorly understood. We find that restricting microbiome maturation during weaning stunts immune system development and increases susceptibility to enteric infection. We developed a gnotobiotic mouse model of the early-life microbiome Pediatric Community (PedsCom). These mice develop fewer peripheral regulatory T cells and less IgA, hallmarks of microbiota-driven immune system development...
March 22, 2023: Cell Host & Microbe
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JOURNAL ARTICLE
Melania M Bembea, Laura L Loftis, Ravi R Thiagarajan, Cameron C Young, Timothy P McCadden, Margaret M Newhams, Suden Kucukak, Elizabeth H Mack, Julie C Fitzgerald, Courtney M Rowan, Aline B Maddux, Amanda R Kolmar, Katherine Irby, Sabrina Heidemann, Stephanie P Schwartz, Michele Kong, Hillary Crandall, Kevin M Havlin, Aalok R Singh, Jennifer E Schuster, Mark W Hall, Kari A Wellnitz, Mia Maamari, Mary G Gaspers, Ryan A Nofziger, Peter Paul C Lim, Ryan W Carroll, Alvaro Coronado Munoz, Tamara T Bradford, Melissa L Cullimore, Natasha B Halasa, Gwenn E McLaughlin, Pia S Pannaraj, Natalie Z Cvijanovich, Matt S Zinter, Bria M Coates, Steven M Horwitz, Charlotte V Hobbs, Heda Dapul, Ana Lia Graciano, Andrew D Butler, Manish M Patel, Laura D Zambrano, Angela P Campbell, Adrienne G Randolph
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has been used successfully to support adults with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related cardiac or respiratory failure refractory to conventional therapies. Comprehensive reports of children and adolescents with SARS-CoV-2-related ECMO support for conditions, including multisystem inflammatory syndrome in children (MIS-C) and acute COVID-19, are needed. DESIGN: Case series of patients from the Overcoming COVID-19 public health surveillance registry...
May 1, 2023: Pediatric Critical Care Medicine
#33
JOURNAL ARTICLE
Kristin L Moffitt, Mari M Nakamura, Cameron C Young, Margaret M Newhams, Natasha B Halasa, J Nelson Reed, Julie C Fitzgerald, Philip C Spinella, Vijaya L Soma, Tracie C Walker, Laura L Loftis, Aline B Maddux, Michele Kong, Courtney M Rowan, Charlotte V Hobbs, Jennifer E Schuster, Becky J Riggs, Gwenn E McLaughlin, Kelly N Michelson, Mark W Hall, Christopher J Babbitt, Natalie Z Cvijanovich, Matt S Zinter, Mia Maamari, Adam J Schwarz, Aalok R Singh, Heidi R Flori, Shira J Gertz, Mary A Staat, John S Giuliano, Saul R Hymes, Katharine N Clouser, John McGuire, Christopher L Carroll, Neal J Thomas, Emily R Levy, Adrienne G Randolph
BACKGROUND: Community-onset bacterial coinfection in adults hospitalized with coronavirus disease 2019 (COVID-19) is reportedly uncommon, though empiric antibiotic use has been high. However, data regarding empiric antibiotic use and bacterial coinfection in children with critical illness from COVID-19 are scarce. METHODS: We evaluated children and adolescents aged <19 years admitted to a pediatric intensive care or high-acuity unit for COVID-19 between March and December 2020...
March 2023: Open Forum Infectious Diseases
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JOURNAL ARTICLE
Libby J Bradley, Kimberly E Meyer, Taylor C Robertson, Marcel Satsky Kerr, Scott D Maddux, Amber J Heck, Rustin E Reeves, Emma K Handler
Online learning has become an essential part of mainstream higher education. With increasing enrollments in online anatomy courses, a better understanding of effective teaching techniques for the online learning environment is critical. Active learning has previously shown many benefits in face-to-face anatomy courses, including increases in student satisfaction. Currently, no research has measured student satisfaction with active learning techniques implemented in an online graduate anatomy course. This study compares student satisfaction across four different active learning techniques (jigsaw, team-learning module, concept mapping, and question constructing), with consideration of demographics and previous enrollment in anatomy and/or online courses...
March 22, 2023: Anatomical Sciences Education
#35
JOURNAL ARTICLE
Karlien J Ter Meulen, Xiaoling Ye, Yuedong Wang, Len A Usvyat, Frank M van der Sande, Constantijn J Konings, Peter Kotanko, Jeroen P Kooman, Franklin W Maddux
No abstract text is available yet for this article.
March 15, 2023: Kidney360
#36
JOURNAL ARTICLE
Joyce C Chang, Cameron C Young, Eyal Muscal, Sara K Sexson Tejtel, Margaret M Newhams, Suden Kucukak, Hillary Crandall, Aline B Maddux, Courtney M Rowan, Natasha B Halasa, Helen A Harvey, Charlotte V Hobbs, Mark W Hall, Michele Kong, Cassyanne L Aguiar, Jennifer E Schuster, Julie C Fitzgerald, Aalok R Singh, Kari Wellnitz, Ryan A Nofziger, Natalie Z Cvijanovich, Elizabeth H Mack, Adam J Schwarz, Sabrina Heidemann, Jane W Newburger, Laura D Zambrano, Angela P Campbell, Manish M Patel, Adrienne G Randolph, Mary Beth F Son
OBJECTIVE: Evidence regarding effectiveness of interleukin-1 receptor antagonism in Multisystem Inflammatory Syndrome in Children (MIS-C) is lacking. We characterized variation in initial treatment with anakinra and evaluated cardiovascular outcomes associated with adding anakinra to standard initial therapy. METHODS: We conducted a retrospective cohort study of MIS-C cases in a U.S. surveillance registry November 2020-December 2021. Day 0 was the first calendar day of immunomodulatory treatment...
March 12, 2023: Arthritis & Rheumatology
#37
Cameron C Young, Kerri L LaRovere, Margaret M Newhams, Suden Kucukak, Shira J Gertz, Aline B Maddux, Natasha B Halasa, Hillary Crandall, Michele Kong, Julie C Fitzgerald, Katherine Irby, Adrienne G Randolph, Angela P Campbell, Mary Beth F Son
Aseptic meningitis is a rare but potentially serious complication of intravenous immunoglobulin treatment. In this case series, meningitic symptoms following intravenous immunoglobulin initiation in patients with multisystem inflammatory syndrome were rare (7/2,086 [0.3%]). However, they required the need for additional therapy and/or readmission.
June 2023: Journal of Pediatrics
#38
JOURNAL ARTICLE
Michele H Maddux, Megan Drovetta, Laura M Mackner, Jill Plevinski, Brandi N Whitaker
BACKGROUND: Little is known about depression screening practices in pediatric IBD care. This study summarizes depression screening within IBD centers in the ImproveCareNow Collaborative Network. METHODS: Pediatric IBD providers across 79 IBD centers completed an online survey on current practices surrounding depression screening. RESULTS: Half of centers report doing annual depression screening, largely for patients 12-14 years. The Patient Health Questionnaire (PHQ-9) is most often used...
February 24, 2023: Journal of Pediatric Gastroenterology and Nutrition
#39
JOURNAL ARTICLE
Suhhyun Kim, Lyndee A Ward, Lauren N Butaric, Scott D Maddux
OBJECTIVES: Although research into human maxillary sinus (MS) morphology has overwhelmingly focused on sinus volume, other aspects of morphology (e.g., overall shape, mucosal surface area) factor prominently in hypotheses regarding MS form and function. Here, we investigate MS volume in conjunction with measures of MS shape and surface area in a large, diverse sample of modern humans. We test whether variation in MS volume is associated with predictable changes in MS shape (i.e., allometry) and investigate the influence of MS size-shape scaling on mucosal surface area dynamics...
December 2022: American journal of biological anthropology
#40
MULTICENTER STUDY
Derek M Blankenship, Len Usvyat, Michael A Kraus, Dinesh K Chatoth, Rachel Lasky, Joseph E Turk, Franklin W Maddux
INTRODUCTION: Inadequate predialysis care and education impacts the selection of a dialysis modality and is associated with adverse clinical outcomes. Transitional care units (TCUs) aim to meet the unmet educational needs of incident dialysis patients, but their impact beyond increasing home dialysis utilization has been incompletely characterized. METHODS: This retrospective study included adults initiating in-center hemodialysis at a TCU, matched to controls (1:4) with no TCU history initiating in-center hemodialysis...
April 2023: Hemodialysis International
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