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https://www.readbyqxmd.com/read/28728772/a-pilot-study-evaluating-the-impact-of-an-adherence-promoting-intervention-among-nonadherent-youth-with-inflammatory-bowel-disease
#1
Michele Maddux, Shawna Ricks, Stephen Delurgio, Kevin Hommel
PURPOSE: This study examined the feasibility and impact of a multicomponent adherence intervention among youth with Inflammatory Bowel Disease (IBD) who presented to clinic with poor adherence. DESIGN AND METHODS: Medical providers referred twelve adolescents for the intervention, who participated in 4 weekly visits with a caregiver aimed at improving adherence. RESULTS: Intervention session attendance was 100% and the intervention was rated as feasible and acceptable...
July 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28666073/to-cool-or-too-cool-is-reducing-dialysate-temperature-the-optimal-approach-to-preventing-intradialytic-hypotension
#2
John W Larkin, Marta M Reviriego-Mendoza, Len A Usvyat, Peter Kotanko, Franklin W Maddux
Abnormal decreases in blood pressure during hemodialysis are frequent in end stage renal disease (ESRD) patients treated with hemodialysis, and thought to be largely due to an inadequate cardiovascular response to the rapid blood volume decline. Intradialytic hypotension (IDH) and cardiac instability during dialysis can increase risks for negative health consequences and is possibly preventable though several types of interventions. One intervention that holds promise for prevention of IDH in hemodialysis patients is to reduce the temperature of the dialysate to or below the patient's core temperature...
June 30, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28587714/real-world-effectiveness-of-sucroferric-oxyhydroxide-in-patients-on-chronic-hemodialysis-a-retrospective-analysis-of-pharmacy-data%C3%A2
#3
Daniel W Coyne, Linda H Ficociello, Vidhya Parameswaran, Ludmila Anderson, Sharanya Vemula, Norma J Ofsthun, Claudy Mullon, Franklin W Maddux, Robert J Kossmann, Stuart M Sprague
AIMS: Hyperphosphatemia has been associated with an increased risk of mortality in patients with end-stage renal disease. We sought to assess the real-world effectiveness of sucroferric oxyhydroxide (SO), an iron-based phosphate binder (PB), in control of serum phosphorus levels, and to determine the associated pill burden in hemodialysis patients. MATERIALS AND METHODS: Adult, in-center hemodialysis patients first prescribed SO through a renal pharmacy service as part of routine clinical care between April 1, 2014 and March 31, 2015 were included in the analysis...
June 7, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28531888/right-trac%C3%A2-post-hospitalization-care-transitions-program-to-reduce-readmissions-for-hemodialysis-patients
#4
Rebecca L Wingard, Kathryn McDougall, Billie Axley, Andrew Howard, Cathleen O''Keefe, Nancy Armistead, Janet R Lynch, Sophia Rosen, Len Usvyat, Franklin W Maddux
BACKGROUND: Hemodialysis (HD) patients have high hospitalization rates. This nonrandomized trial tested the effect of a bundle of renal-specific "Right TraC™" strategies on 30-day all-cause readmission rates and, secondarily, 90-day readmissions and overall admissions among HD patients. METHODS: Twenty-six Fresenius clinics in West Virginia, Ohio, and Kentucky participated in the interventions. Eighteen matched clinics served as controls; intervention clinics also served as their own controls...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28474194/improving-compliance-with-intersocietal-accreditation-commission-iac-reporting-standards-a-serial-comparison-of-523-labs-over-seven-years
#5
P Timothy Maddux, Mary Beth Farrell, Joseph A Ewing, Peter L Tilkemeier
BACKGROUND: The aim of this study was to evaluate reporting compliance of laboratories applying for serial accreditation by the Intersocietal Accreditation Commission (IAC) and compare compliance based on laboratory characteristics. METHODS: All laboratories applying for IAC accreditation for the first time in 2008 and then twice more (2011-2014) were evaluated for compliance with 18 reporting elements. The elements were ranked into three severity groups (high/moderate/low)...
May 4, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28416322/nephrologists-and-integrated-kidney-disease-care-roles-and-skills-essential-for-nephrologists-for-future-success
#6
Allen R Nissenson, Franklin W Maddux
As the costs of caring for patients with end-stage renal disease have grown, so has the pressure to provide high-quality care at a lower cost. Prompted in large part by regulatory and legislative changes, reimbursement is shifting from a fee-for-service environment to one of value-based payment models. Nephrologists in this new environment are increasingly responsible not only for direct patient care, but also for population management and the associated clinical outcomes for this vulnerable population. This Perspective article aims to recognize the key role and skills needed in order to successfully practice within these new value-based care models...
July 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28372498/innate-immune-function-and-organ-failure-recovery-in-adults-with-sepsis
#7
Aline B Maddux, Terra D Hiller, Katherine H Overdier, Laura L Pyle, Ivor S Douglas
PURPOSE: Sepsis stimulates pro- and anti-inflammatory immune responses. The innate immune response is critical to organ injury repair. We tested for an association between innate immune function and organ function recovery in a prospective cohort of immune-competent adults with sepsis. METHODS: We conducted a prospective observational cohort study enrolling immune-competent adults with sepsis. We tested innate immune function by quantification of lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) α production capacity in whole blood samples on hospital days 1, 4, and 6...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28358527/-going-out-of-the-box-close-intercultural-friendships-and-romantic-relationships-spark-creativity-workplace-innovation-and-entrepreneurship
#8
Jackson G Lu, Andrew C Hafenbrack, Paul W Eastwick, Dan J Wang, William W Maddux, Adam D Galinsky
The present research investigates whether close intercultural relationships promote creativity, workplace innovation, and entrepreneurship-outcomes vital to individual and organizational success. We triangulate on these questions with multiple methods (longitudinal, experimental, and field studies), diverse population samples (MBA students, employees, and professional repatriates), and both laboratory and real-world measures. Using a longitudinal design over a 10-month MBA program, Study 1 found that intercultural dating predicted improved creative performance on both divergent and convergent thinking tasks...
March 30, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28159641/microflow-imaging-analyses-reflect-mechanisms-of-aggregate-formation-comparing-protein-particle-data-sets-using-the-kullback-leibler-divergence
#9
Nathaniel R Maddux, Austin L Daniels, Theodore W Randolph
Subvisible particles in therapeutic protein formulations are an increasing manufacturing and regulatory concern because of their potential to cause adverse immune responses. Flow imaging microscopy is used extensively to detect subvisible particles and investigate product deviations, typically by comparing imaging data using histograms of particle descriptors. Such an approach discards much information and requires effort to interpret differences, which is problematic when comparing many data sets. We propose to compare imaging data using the Kullback-Leibler divergence, an information theoretic measure of the difference of distributions (Kullback S, Leibler RA...
February 1, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28152285/correction
#10
(no author information available yet)
In an interview with Fresenius Medical Care chief medical officer Frank Maddux, MD in the July issue of NN&l ("CMO looks at ways to put meaning behind 'quality care'"), we asked Dr. Maddux if he believed that patients wanted more engagement at home via telehealth with their caregivers. His response should have read, 'For many of our patients, it's not about diagnosing the disease. It is about preventing the known crises events from occurring." The original printed response had read, "...it is about preventing the non-crisis events from occurring...
August 2016: Nephrology News & Issues
https://www.readbyqxmd.com/read/28032773/the-dark-side-of-going-abroad-how-broad-foreign-experiences-increase-immoral-behavior
#11
Jackson G Lu, Jordi Quoidbach, Francesca Gino, Alek Chakroff, William W Maddux, Adam D Galinsky
Because of the unprecedented pace of globalization, foreign experiences are increasingly common and valued. Past research has focused on the benefits of foreign experiences, including enhanced creativity and reduced intergroup bias. In contrast, the present work uncovers a potential dark side of foreign experiences: increased immoral behavior. We propose that broad foreign experiences (i.e., experiences in multiple foreign countries) foster not only cognitive flexibility but also moral flexibility. Using multiple methods (longitudinal, correlational, and experimental), 8 studies (N > 2,200) establish that broad foreign experiences can lead to immoral behavior by increasing moral relativism-the belief that morality is relative rather than absolute...
January 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28011981/nicotine-induced-enhancement-of-pavlovian-alcohol-seeking-behavior-in-rats
#12
Jean-Marie N Maddux, Nadia Chaudhri
RATIONALE: Nicotine enhances responding elicited by Pavlovian cues that predict positive outcomes. OBJECTIVES: We tested the hypothesis that nicotine acting at nicotinic acetylcholine receptors (nAChRs) would augment Pavlovian alcohol-seeking. METHODS: Male, Long-Evans rats with unrestricted access to food and water were acclimated to drinking 15% ethanol in their home cages and then given Pavlovian conditioning sessions in which each trial of a 15-s conditioned stimulus (CS, 12 trials/session) was paired with 0...
December 23, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/28000407/zygomaticomaxillary-morphology-and-maxillary-sinus-form-and-function-how-spatial-constraints-influence-pneumatization-patterns-among-modern-humans
#13
Scott D Maddux, Lauren N Butaric
Previous research has suggested that the maxillary sinuses may act as "zones of accommodation" for the nasal region, minimizing the impact of climatic-related changes in nasal cavity breadth on surrounding skeletal structures. However, a recent study among modern human crania has identified that, in addition to nasal cavity breadth, sinus morphology also tracks lateral facial form, especially anterior-posterior positioning of the zygomatics. Here, we expand upon this previous study to further investigate these covariation patterns by employing three samples with distinct combinations of nasal and zygomatic morphologies: Northern Asians (n = 28); sub-Saharan Africans (n = 30); and Europeans (n = 29)...
January 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27930443/otolith-dysfunction-in-persons-with-both-diabetes-and-benign-paroxysmal-positional-vertigo
#14
Linda J DʼSilva, Hinrich Staecker, James Lin, Christy Maddux, John Ferraro, Hongying Dai, Patricia M Kluding
OBJECTIVE: Vestibular dysfunction is a well-recognized complication of type 2 diabetes (DM) that may contribute to increased fall risk. The prevalence of benign paroxysmal positional vertigo (BPPV) is higher in people with DM. The impact of DM on the otolith organs of the vestibular system in people with BPPV is unknown. The purpose of this study was to analyze otolith function using vestibular-evoked myogenic potential (VEMP) tests in people with DM and concurrent BPPV (BPPV + DM), and to examine the relationships between VEMP variables and diabetes-related variables...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/27866964/dialysate-potassium-serum-potassium-mortality-and-arrhythmia-events-in-hemodialysis-results-from-the-dialysis-outcomes-and-practice-patterns-study-dopps
#15
MULTICENTER STUDY
Angelo Karaboyas, Jarcy Zee, Steven M Brunelli, Len A Usvyat, Daniel E Weiner, Franklin W Maddux, Allen R Nissenson, Michel Jadoul, Francesco Locatelli, Wolfgang C Winkelmayer, Friedrich K Port, Bruce M Robinson, Francesca Tentori
BACKGROUND: Sudden death is a leading cause of death in patients on maintenance hemodialysis therapy. During hemodialysis sessions, the gradient between serum and dialysate levels results in rapid electrolyte shifts, which may contribute to arrhythmias and sudden death. Controversies exist about the optimal electrolyte concentration in the dialysate; specifically, it is unclear whether patient outcomes differ among those treated with a dialysate potassium concentration of 3 mEq/L compared to 2 mEq/L...
February 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27834390/varenicline-reduces-context-induced-relapse-to-alcohol-seeking-through-actions-in-the-nucleus-accumbens
#16
Franca Lacroix, Annie Pettorelli, Jean-Marie N Maddux, Atyeh Heidari-Jam, Nadia Chaudhri
Varenicline, a pharmacotherapy for tobacco addiction, reduces alcohol consumption in humans and rodents. The therapeutic potential of varenicline would escalate if it also diminished conditioned responses elicited by alcohol-predictive cues, which can precipitate relapse in abstinent individuals. We investigated this application, along with the underlying neural substrates, using a robust preclinical assay in which relapse to alcohol-seeking was triggered by re-exposure to an alcohol-associated environmental context...
April 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27830436/improved-compliance-with-reporting-standards-a-retrospective-analysis-of-intersocietal-accreditation-commission-nuclear-cardiology-laboratories
#17
P Tim Maddux, Mary Beth Farrell, Joseph A Ewing, Peter L Tilkemeier
BACKGROUND: In 2011, Tilkemeier et al reported significant nuclear cardiology laboratory noncompliance with reporting standards. The aim of this study was to identify and examine noncompliant reporting elements with the Intersocietal Accreditation Commission Nuclear/PET (IAC) Reporting Standards and to compare compliance between 2008 and 2014. METHODS: This was a retrospective study of compliance with 18 reporting elements utilizing accreditation findings from all laboratories applying for accreditation in 2008 and 2014...
November 9, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27789006/improving-outcomes-of-dialysis-patients-by-population-health-management-the-global-chief-medical-officer-initiative
#18
Bernard Canaud, Jörgen Hegbrant, Allen R Nissenson, Claudia Barth, Franklin Maddux, Michael Etter, Mahesh Krishnan
No abstract text is available yet for this article.
October 22, 2016: Lancet
https://www.readbyqxmd.com/read/27670377/ecogeographic-variation-across-morphofunctional-units-of-the-human-nose
#19
Scott D Maddux, Lauren N Butaric, Todd R Yokley, Robert G Franciscus
OBJECTIVES: Although the internal nose is overwhelmingly responsible for heat and moisture exchange during respiration, external nasal morphology is more commonly cited as evincing climatic adaptation in humans. Here, we assess variation across all four morphofunctional units of the complete nasorespiratory tract (external pyramid, nasal aperture, internal nasal fossa, and nasopharynx) to determine which units provide the strongest evidence of climatic adaptation. MATERIALS AND METHODS: We employ 20 linear measurements collected on 837 modern human crania from major geographic (Arctic Circle, Asia, Australia, Europe, Africa) and climatic (polar, temperate, hot-arid, tropical) zones...
January 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27433957/cardiac-structure-and-function-in-elite-para-cyclists-with-spinal-cord-injury
#20
Jonathan H Kim, Jennifer L Trilk, Ryan Smith, Irfan Asif, Paul Tim Maddux, Yi-An Ko, Michael S Emery
PURPOSE: We sought to explore the association between the spinal cord injury (SCI) level on the cardiac structure and the function observed in elite para-cyclists. METHODS: Cross-sectional echocardiographic data from 44 elite SCI hand cyclists (39.8 ± 9 yr, 68% male/32% female) stratified by the level of SCI (cervical, N = 9; T1-T5, N = 10; below T5, N = 25) and 19 non-SCI blind/visually impaired (BVI) tandem cyclists (32.4 ± 7 yr, 58% male/42% female) were analyzed before the initiation of international competition...
August 2016: Medicine and Science in Sports and Exercise
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