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https://www.readbyqxmd.com/read/29909936/association-of-smoking-status-with-mortality-and-hospitalization-in-hemodialysis-patients
#1
Nien-Chen Li, Ravi I Thadhani, Marta Reviriego-Mendoza, John W Larkin, Franklin W Maddux, Norma J Ofsthun
RATIONALE & OBJECTIVE: The relationship between tobacco smoking and comorbid condition outcomes in hemodialysis (HD) patients is not well understood. This study examined the association of tobacco smoking status with hospitalization and mortality in HD patients. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Adult HD patients at 2,223 US dialysis centers with HD vintage of 30 days or less who completed a tobacco smoking status survey as part of standard care between April 2013 and June 2015...
June 14, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29688512/greater-fluid-overload-and-lower-interdialytic-weight-gain-are-independently-associated-with-mortality-in-a-large-international-hemodialysis-population
#2
Manfred Hecking, Ulrich Moissl, Bernd Genser, Hugh Rayner, Indranil Dasgupta, Stefano Stuard, Andrea Stopper, Charles Chazot, Franklin W Maddux, Bernard Canaud, Friedrich K Port, Carmine Zoccali, Peter Wabel
Background: Fluid overload and interdialytic weight gain (IDWG) are discrete components of the dynamic fluid balance in haemodialysis patients. We aimed to disentangle their relationship, and the prognostic importance of two clinically distinct, bioimpedance spectroscopy (BIS)-derived measures, pre-dialysis and post-dialysis fluid overload (FOpre and FOpost) versus IDWG. Methods: We conducted a retrospective cohort study on 38 614 incident patients with one or more BIS measurement within 90 days of haemodialysis initiation (1 October 2010 through 28 February 2015)...
April 20, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29664834/alkaline-phosphatase-activity-and-endotoxemia-after-infant-cardiothoracic-surgery
#3
Jesse A Davidson, Tracy T Urban, Suhong Tong, Aline Maddux, Gerald Hill, Benjamin S Frank, John D Watson, James Jaggers, Eric A F Simões, Paul Wischmeyer
OBJECTIVE: Infant cardiopulmonary bypass (CPB) increases intestinal permeability leading to endotoxemia. Alkaline phosphatase (AP) reduces endotoxin toxicity in vitro but its effects on endotoxemia in human disease are poorly understood. We assessed the association between serum AP activity and endotoxemia in infants undergoing CPB and determined the effect of ex vivo addition of AP on endotoxemia. METHODS: Prospective cohort study of 62 infants ≤120 days of age undergoing CPB...
April 16, 2018: Shock
https://www.readbyqxmd.com/read/29571453/increasing-inclusion-of-patients-with-advanced-chronic-kidney-disease-in-cardiovascular-clinical-trials
#4
Roy O Mathew, Sripal Bangalore, Mandeep S Sidhu, Jerome L Fleg, Franklin W Maddux
No abstract text is available yet for this article.
April 2018: Kidney International
https://www.readbyqxmd.com/read/29509635/mental-health-service-needs-in-children-and-adolescents-with-inflammatory-bowel-disease-and-other-chronic-gastrointestinal-disorders
#5
Jessie J Wong, Michele Maddux, K T Park
No abstract text is available yet for this article.
March 5, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29499026/mortality-after-pediatric-critical-illness-made-it-home-still-vulnerable
#6
Aline B Maddux, Tellen D Bennett
No abstract text is available yet for this article.
March 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29478044/relationships-between-neighborhood-walkability-and-objectively-measured-physical-activity-levels-in-hemodialysis-patients
#7
Maggie Han, Xiaoling Ye, Priscila Preciado, Schantel Williams, Israel Campos, Marcee Bonner, Candace Young, Daniel Marsh, John W Larkin, Len A Usvyat, Franklin W Maddux, Roberto Pecoits-Filho, Peter Kotanko
BACKGROUND/AIMS: Neighborhood walkability is associated with indicators of health in the general population. We explored the association between neighborhood walkability and daily steps in hemodialysis (HD) patients. METHODS: We measured daily steps over 5 weeks using Fitbit Flex (Fitbit, San Francisco, CA, USA) and retrieved Walk Score® (WS) data by patient's home ZIP code (www.walkscore.com; 0 = poorest walkability; 100 = greatest walkability). RESULTS: HD patients took a mean of 6,393 ± 3,550 steps/day (n = 46)...
2018: Blood Purification
https://www.readbyqxmd.com/read/29435777/clinical-review-of-the-pharmacogenomics-of-direct-oral-anticoagulants
#8
REVIEW
Andrew S Tseng, Reema D Patel, Heidi E Quist, Adrijana Kekic, Jacob T Maddux, Christopher B Grilli, Fadi E Shamoun
PURPOSE: There is growing interest in the use of pharmacogenomics to optimize the safety and efficacy of anticoagulation therapy. While the pharmacogenomics of warfarin have been well-studied, the pharmacogenomics of direct oral anticoagulants (DOACs) continue to be a fledgling, but growing, field of interest. We present a pertinent clinical review of the present state of research on the pharmacogenomics of DOACs. METHODS AND RESULTS: The present article is a review of pertinent clinical and scientific research on the pharmacogenomics of DOACs between January 2008 and December 2017 using MEDLINE and the United States National Institutes of Health Clinical Trials Registry...
February 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29423211/depressive-affect-in-incident-hemodialysis-patients
#9
Kathryn A McDougall, John W Larkin, Rebecca L Wingard, Yue Jiao, Sophia Rosen, Lin Ma, Len A Usvyat, Franklin W Maddux
Background: The prevalence of depressive affect is not well defined in the incident hemodialysis (HD) population. We investigated the prevalence of and associated risk factors and hospitalization rates for depressive affect in incident HD patients. Methods: We performed a prospective investigation using the Patient Health Questionnaire 2 (PHQ2) depressive affect assessment. From January to July of 2013 at 108 in-center clinics randomly selected across tertiles of baseline quality measures, we contacted 577 and 543 patients by telephone for depressive affect screening...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29417986/three-dimensional-anatomy-of-the-anthropoid-bony-pelvis
#10
Carol V Ward, Scott D Maddux, Emily R Middleton
OBJECTIVES: Pelvic form is hypothesized to reflect locomotor adaptation in anthropoids. Most observed variation is found in the ilium, which traditionally is thought to reflect thoracic and shoulder morphology. This article examines the articulated bony pelvis of anthropoids in three dimensions (3D) to test hypothesized variation in pelvic anatomy related to overall torso form. MATERIALS AND METHODS: Sixty landmarks were collected on articulated pelves from 240 anthropoid individuals...
May 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29414829/the-association-of-weekly-pre-hemodialysis-systolic-blood-pressure-and-following-week-mortality
#11
Dugan Maddux, Len A Usvyat, Danqing Xu, Yuedong Wang, Peter Kotanko, Frank M van der Sande, Jeroen P Kooman, Franklin W Maddux
BACKGROUND/AIMS: Few studies examine the impact of systolic blood pressure (SBP) on mortality in the incident hemodialysis (HD) period, and throughout the first HD year. This large retrospective observational study analyzes the impact of "current" and cumulative low preSBP <110 mmHg (L), and variations in preSBP on short-term (1 week) mortality over the first HD year. METHODS: Weekly mean preSBP for HD weeks 1 to 51 was categorized into L or high preSBP>=110 mmHg (H) for each patient...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29365272/awake-or-sedate%C3%A2-do-we-know-the-best-state
#12
Aline B Maddux, Jerry J Zimmerman
No abstract text is available yet for this article.
January 24, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29210926/hospital-readmissions-after-pediatric-trauma
#13
Aline B Maddux, Peter E DeWitt, Peter M Mourani, Tellen D Bennett
OBJECTIVES: To determine the rate, etiology, and timing of unplanned and planned hospital readmissions and to identify risk factors for unplanned readmission in children who survive a hospitalization for trauma. DESIGN: Multicenter retrospective cohort study of a probabilistically linked dataset from the National Trauma Data Bank and the Pediatric Health Information System database, 2007-2012. SETTING: Twenty-nine U.S. children's hospitals...
January 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29166771/the-effects-of-yoga-on-stress-and-psychological-health-among-employees-an-8-and-16-week-intervention-study
#14
Rachel E Maddux, Daiva Daukantaité, Una Tellhed
BACKGROUND: The stresses of modern work life necessitate effective coping strategies that are accessible and affordable to the general public. Yoga has been found to reduce stress in clinical samples, but studies are needed to examine standard gym yoga classes among functional individuals. OBJECTIVES: This study investigated the effects of 8- and 16-week gym yoga on stress and psychological health. DESIGN AND METHOD: Ninety individuals reporting moderate-to-high stress were randomly assigned to 16 consecutive weeks of yoga, or to a waitlist crossover group who did not practice yoga for 8 weeks then practiced yoga for 8 weeks...
March 2018: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/29149476/clinical-parameters-before-and-after-the-transition-to-dialysis
#15
Dugan W Maddux, Len A Usvyat, Terry Ketchersid, Yue Jiao, Tommy C Blanchard, Peter Kotanko, Frank M van der Sande, Jeroen P Kooman, Franklin W Maddux
INTRODUCTION: The transition from pre-dialysis chronic kidney disease (CKD) to post-dialysis start is a critical period associated with high patient mortality and increased hospital admissions. Little is known about the trends of key clinical and laboratory parameters through this time of transition to start dialysis. METHODS: De-identified data including demographics, vital signs, lab results, and eGFR from the Fresenius Medical Care-CKD Registry were analyzed to determine trends in clinical and laboratory parameters through the time of transition from 12 months pre-dialysis start to 12 months post-dialysis start...
April 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29062318/evaluation-of-recombinant-attenuated-salmonella-vaccine-strains-for-broad-protection-against-extraintestinal-pathogenic-escherichia-coli
#16
Jacob T Maddux, Zachary R Stromberg, Roy Curtiss Iii, Melha Mellata
Antibiotic-resistant bacterial infections are difficult to treat, producing a burden on healthcare and the economy. Extraintestinal pathogenic Escherichia coli (ExPEC) strains frequently carry antibiotic resistance genes, cause infections outside of the intestine, and are causative agents of hospital-acquired infections. Developing a prevention strategy against this pathogen is challenging due to its antibiotic resistance and antigenic diversity. E. coli common pilus (ECP) is frequently found in ExPEC strains and may serve as a common antigen to induce protection against several ExPEC serotypes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28972776/charge-trapping-versus-exciton-delocalization-in-cdse-quantum-dots
#17
Jamie J Grenland, Cassandra J A Maddux, David F Kelley, Anne Myers Kelley
The spectroscopic and photophysical similarities and differences between charge trapping by surface ligands on CdSe quantum dots and charge delocalization into the shell in excited CdSe core/shell nanocrystals are discussed. Optical absorption and resonance Raman spectroscopies are used to study small CdSe quantum dots coated with organic ligands that accept electrons (methyl viologen) or holes (phenothiazine, 4-methylbenzenethiol), as well as with semiconductor shells that delocalize electrons (CdS) or holes (CdTe)...
October 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28943158/dynamics-of-nutritional-competence-in-the-last-year-before-death-in-a-large-cohort-of-us-hemodialysis-patients
#18
Xiaoling Ye, Marijke J E Dekker, Franklin W Maddux, Peter Kotanko, Constantijn J A M Konings, Jochen G Raimann, Frank M van der Sande, Len A Usvyat, Jeroen P Kooman, Stephan Thijssen
OBJECTIVES: Recently, a new Nutritional Competence Score (NCS) has been shown to associate with hospitalization and outcome in hemodialysis patients. The aim of this study was to investigate the dynamics, the individual components, and the impact of hospitalizations of this score's trajectory in the year before death. In addition, we investigated whether dynamics in the NCS add additional independent prognostic value over a single cross-sectional assessment. DESIGN: We included all Fresenius Medical Care North America patients who initiated hemodialysis between January 1, 2006, and December 31, 2011 with data on all 5 NCS components (serum albumin, creatinine, phosphate, equilibrated normalized protein catabolic rate, and interdialytic weight gain) in at least 1 month...
November 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28898574/integrating-kidney-transplantation-into-value-based-care-for-people-with-renal-failure
#19
Benjamin E Hippen, Franklin W Maddux
Healthcare reimbursement is increasingly tied to value instead of volume, with special attention paid to resource-intensive populations such as patients with renal disease. To this end, Medicare has sponsored pilot projects to encourage providers to develop care coordination and population health management strategies to provide quality care while reducing resource utilization. In this Personal Viewpoint essay, we argue in favor of expanding one such pilot project-the Comprehensive ESRD Care (CEC) initiative-to include patients with advanced chronic kidney disease and kidney transplant recipients...
January 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/28851317/the-dynamics-of-the-metabolism-of-acetate-and-bicarbonate-associated-with-use-of-hemodialysates-in-the-abchd-trial-a-phase-iv-prospective-single-center-single-blind-randomized-cross-over-two-week-investigation
#20
RANDOMIZED CONTROLLED TRIAL
William B Smith, Sandy Gibson, George E Newman, Kendra S Hendon, Margarita Askelson, James Zhao, Jamil Hantash, Brigid Flanagan, John W Larkin, Len A Usvyat, Ravi I Thadhani, Franklin W Maddux
BACKGROUND: In the United States, hemodialysis (HD) is generally performed via a bicarbonate dialysate. It is not known if small amounts of acid used in dialysate to buffer the bicarbonate can meaningfully contribute to overall buffering administered during HD. We aimed to investigate the metabolism of acetate with use of two different acid buffer concentrates and determine if it effects blood bicarbonate concentrations in HD patients. METHODS: The Acid-Base Composition with use of hemoDialysates (ABChD) trial was a Phase IV, prospective, single blind, randomized, cross-over, 2 week investigation of peridialytic dynamics of acetate and bicarbonate associated with use of acid buffer concentrates...
August 29, 2017: BMC Nephrology
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