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https://www.readbyqxmd.com/read/28534880/a-tale-of-two-risks-smoking-diabetes-and-the-subgingival-microbiome
#1
Sukirth M Ganesan, Vinayak Joshi, Megan Fellows, Shareef M Dabdoub, Haikady N Nagaraja, Benjamin O'Donnell, Neeta Rohit Deshpande, Purnima S Kumar
Although smoking and diabetes have been established as the only two risk factors for periodontitis, their individual and synergistic impacts on the periodontal microbiome are not well studied. The present investigation analyzed 2.7 million 16S sequences from 175 non-smoking normoglycemic individuals (controls), smokers, diabetics and diabetic smokers with periodontitis as well as periodontally healthy controls, smokers and diabetics to assess subgingival bacterial biodiversity and co-occurrence patterns. The microbial signatures of periodontally healthy smokers, but not diabetics, were highly aligned with the disease-associated microbiomes of their respective cohorts...
May 23, 2017: ISME Journal
https://www.readbyqxmd.com/read/28532856/implementation-of-a-referral-to-discharge-glycemic-control-initiative-for-reduction-of-surgical-site-infections-in-gynecologic-oncology-patients
#2
Laura Hopkins, Jennifer Brown-Broderick, James Hearn, Janine Malcolm, James Chan, Wendy Hicks-Boucher, Filomena De Sousa, Mark C Walker, Sylvain Gagné
OBJECTIVE(S): To evaluate the frequency of surgical site infections before and after implementation of a comprehensive, multidisciplinary perioperative glycemic control initiative. STUDY METHODS: As part of a CUSP (Comprehensive Unit-based Safety Program) initiative, between January 5 and December 18, 2015, we implemented comprehensive, multidisciplinary glycemic control initiative to reduce SSI rates in patients undergoing major pelvic surgery for a gynecologic malignancy ('Group II')...
May 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28528338/chronic-glibenclamide-treatment-attenuates-walker-256-tumour-growth-in-prediabetic-obese-rats
#3
Claudinéia Conationi da Silva Franco, Carina Previate, Kátia Gama de Barros Machado, Silvano Piovan, Rosiane Aparecida Miranda, Kelly Valério Prates, Veridiana Mota Moreira, Júlio Cezar de Oliveira, Luiz Felipe Barella, Rodrigo Mello Gomes, Flávio Andrade Francisco, Isabela Peixoto Martins, Audrei Pavanello, Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Ananda Malta, Aline Amenencia de Souza, Vander Silva Alves, Sandra da Silva Silveira, Maria Raquel Marçal Natali, Jean Carlos Fernando Besson, Hely de Morais, Helenir Medri de Souza, Juliane Rocha de Sant Anna, Marialba Avezum Alves de Castro Prado, Paulo Cezar de Freitas Mathias
BACKGROUND/AIMS: The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients. However, the mechanisms underlying this observation remain unclear. The aim of the present work was to evaluate whether obese adult rats that were chronically treated with an antidiabetic drug, glibenclamide, exhibit resistance to rodent breast carcinoma growth...
May 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28526024/protective-effect-on-the-coronary-microcirculation-of-patients-with-diabetes-by-clopidogrel-or-ticagrelor-predict-study-rationale-and-design-a-randomized-multicenter-clinical-trial-using-intracoronary-multimodal-physiology
#4
Enrico Cerrato, Alicia Quirós, Mauro Echavarría-Pinto, Hernan Mejia-Renteria, Andres Aldazabal, Nicola Ryan, Nieves Gonzalo, Pilar Jimenez-Quevedo, Luis Nombela-Franco, Pablo Salinas, Iván J Núñez-Gil, José Ramón Rumoroso, Antonio Fernández-Ortiz, Carlos Macaya, Javier Escaned
BACKGROUND: In diabetic patients a predisposed coronary microcirculation along with a higher risk of distal particulate embolization during primary percutaneous intervention (PCI) increases the risk of peri-procedural microcirculatory damage. However, new antiplatelet agents, in particular Ticagrelor, may protect the microcirculation through its adenosine-mediated vasodilatory effects. METHODS: PREDICT is an original, prospective, randomized, multicenter controlled study designed to investigate the protective effect of Ticagrelor on the microcirculation during PCI in patient with diabetes mellitus type 2 or pre-diabetic status...
May 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28521195/diabetes-and-impaired-glucose-metabolism-is-associated-with-more-cold-related-cardiorespiratory-symptoms
#5
Tiina Maria Ikäheimo, Jari Jokelainen, Juhani Hassi, Liisa Hiltunen, Sirkka Keinänen-Kiukaanniemi, Tiina Laatikainen, Pekka Jousilahti, Markku Peltonen, Leena Moilanen, Juha Saltevo, Simo Näyhä
AIMS: Diabetes and impaired glucose metabolism cause metabolic, neural and circulatory disturbances that may predispose to adverse cooling and related symptoms during the cold season. This study assessed the prevalence of cold-related cardiorespiratory symptoms in the general population according to glycaemic status. METHODS: The study population consisted of 2436 men and 2708 women aged 45-74years who participated in the National FINRISK cold sub-studies in 2002 and 2007...
May 4, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28511163/-impact-of-physical-activity-on-anthropometric-indices-in-patients-with-nonalcoholic-fatty-liver-disease-and-pre-diabetes-or-type-2-diabetes
#6
Віталіна В Івачевська
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in many developed countries. The first step, which is offered to all patients with NAFLD includes lifestyle modifications, low-calorie diet, increased physical activity and giving up smoking. OBJECTIVE: to evaluate the efficiency of the daily 30-minute walking at a fast pace on the dynamics of anthropometric indices in patients with NAFLD and pre-diabetes or type 2 diabetes...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28511161/-the-diagnostics-and-clinical-pattern-of-nonalcoholic-fatty-liver-disease-in-patients-with-pre-diabetes-and-type-2-diabetes-and-obesity
#7
Ксенія І Чубірко
INTRODUCTION: The data of epidemiological researches confirm the tendency in increasing of non alcoholic fatty liver disease (NAFLD) in patients with insulin resistance which occurs because of obesity, diabetes type 2 and metabolic syndrome. AIM: Optimization of diagnostic and treatment efficacy in patients with non alcoholic steatosis and steatohepatitis on the background of obesity. MATERIALS AND METHODS: General clinical examination of patients, laboratory and instrumental methods ( fatty liver index, non invasive assessment of liver, morphology, electrocardiography, treadmillergometry, ultrasound examination of abdominal organs, liver elastography,CT,MRI, methods of statistical analysis...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28511152/-pathogenetic-substantiation-of-complex-treatment-of-nonalcoholic-steatohepatitis-and-steatosis-in-patients-with-pre-diabetes-and-type-2-diabetes
#8
Іван В Чопей, Віталіна В Івачевська, Ксенія І Чубірко, Тарас І Гряділь, Михайло М Гечко
INTRODUCTION: Thesis is devoted to the optimization of complex treatment of nonalcoholic steatohepatitis and steatosis in patients with pre-diabetes and type 2 diabetes by acting on carbohydrate and lipid metabolism as well as providing hepatoprotection. AIM: Optimization of diagnostics and treatment in patients treatment of nonalcoholic steatohepatitis and steatosis in patients with pre-diabetes and type 2 diabetes. MATERIAL AND METHODS: Examination and treatment of 117 patients with NAFLD and pre-diabetes and type 2 diabetes was performed...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28486616/the-role-of-vitamin-d-in-the-prevention-of-type-2-diabetes-to-d-or-not-to-d
#9
Edith Angellotti, Anastassios G Pittas
Evidence on biological plausibility from mechanistic studies and highly consistent data from observational studies raise the possibility that optimizing vitamin D status may reduce risk of type 2 diabetes. However, the observational nature of cohort studies precludes a definitive assessment of cause and effect because residual confounding or reverse causation cannot be excluded. Confounding is especially problematic with studies of vitamin D because blood 25-hydoxyvitamin D concentration is not only an excellent biomarker of vitamin D status, reflecting intake or biosynthesis, but also an excellent marker of good overall health...
May 8, 2017: Endocrinology
https://www.readbyqxmd.com/read/28480505/cardamom-supplementation-improves-inflammatory-and-oxidative-stress-biomarkers-in-hyperlipidemic-overweight-and-obese-pre-diabetic-women-a-randomized-double-blind-clinical-trial
#10
Shiva Kazemi, Fatemeh Yaghooblou, Fereydoun Siassi, Abbas Rahimi, Mahsa Ghavipour, Fariba Koohdani, Gity Sotoudeh
BACKGROUND: Several preclinical studies have shown that spices may decrease the risk of chronic diseases. However, it has been suggested that more clinical trials be carried out to strengthen this preclinical evidence. The purpose of the present study was to evaluate the effects of cardamom (Elettaria Cardamomum) supplementation on inflammation and oxidative stress in hyperlipidemic, overweight, and obese pre-diabetic women. METHODS: This randomized, placebo-controlled, double-blind clinical trial was conducted on 80 pre-diabetic subjects...
May 8, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28473873/high-awareness-of-diabetes-in-the-health-care-system-in-greenland-measured-as-a-proportion-of-population-tested-with-glycated-haemoglobin-within-2%C3%A2-years
#11
Michael Lynge Pedersen
BACKGROUND: Sixty years ago diabetes was almost non-existent in Greenland and until the beginning of this century awareness of diabetes was quite minimal. A high prevalence of undiagnosed diabetes has been reported in repeated population surveys. Increased focus on diabetes has been made a priority within the health care system since 2008, and in 2010 glycated haemoglobin was introduced as a diagnostic tool to further facilitate the diagnosis of diabetes. OBJECTIVE: The aim of this study was to estimate the age and gender specific use of glycated haemoglobin in 2014 and 2015, as an indicator of diagnostic activity and awareness of diabetes, and to estimate the prevalence of diagnosed pre-diabetes and diabetes among adults in Greenland aged 20-79 years of age...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28469934/systolic-blood-pressure-but-not-electrocardiogram-qrs-duration-is-associated-with-heart-rate-variability-hrv-a-cross-sectional-study-in-rural-australian-non-diabetics
#12
Yvonne Yin Leng Lee, Herbert F Jelinek, Craig S McLachlan
BACKGROUND: A positive correlation between ECG derived QRS duration and heart rate variability (HRV) parameters had previously been reported in young healthy adults. We note this study used a narrow QRS duration range, and did not adjust for systolic blood pressure. Our aims are to investigate associations between systolic blood pressure (SBP), QRS duration and HRV in a rural aging population. METHODS: A retrospective cross sectional population was obtained from the CSU Diabetes Screening Research Initiative data base where 200 participants had no diabetes or pre-diabetes...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28458887/alterations-in-corneal-nerves-following-crack-cocaine-use-mimic-diabetes-induced-nerve-damage
#13
Whitney L Stuard, Bryan K Gallerson, Danielle M Robertson
SUMMARY: The use of in vivo confocal microscopy (IVCM) is rapidly emerging as an important clinical tool to evaluate changes in corneal sensory nerves as a surrogate measure for diabetic peripheral neuropathy. Commonly used metrics to document and grade the severity of diabetes and risk for diabetic peripheral neuropathy include nerve fiber length, density, branching and tortuosity. In addition to corneal nerves, thinning of the retinal fiber layer has been shown to correlate with the severity of diabetic disease...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28458232/cortisol-mediator-of-association-between-alzheimer-s-disease-and-diabetes-mellitus
#14
REVIEW
Elena Notarianni
Numerous epidemiologic studies have identified an independent association between Alzheimer's disease (AD) and diabetes mellitus (DM), which remains unexplained. This review contends that the association is mediated by mild hypercortisolemia that is manifested in AD by early stages, as empirical evidence indicates that hypercortisolemia is diabetogenic even at subclinical levels. Subclinical Cushing's syndrome is discussed as the paradigm. It is proposed that hypercortisolemia increases the risk of pre-diabetes and DM during early AD and the preceding decades...
April 23, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28457001/plasma-copeptin-and-metabolic-dysfunction-in-individuals-with-bipolar-disorder
#15
Rodrigo B Mansur, Lucas B Rizzo, Camila M Santos, Elson Asevedo, Graccielle R Cunha, Mariane N Noto, Mariana Pedrini, Maiara Zeni-Graiff, Quirino Cordeiro, Roger S McIntyre, Elisa Brietzke
AIM: This study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relationship between copeptin and metabolic parameters. METHODS: We measured plasma levels of copeptin in individuals with BD (N = 55) and healthy controls (N = 21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28456438/accumulated-exposure-to-unemployment-is-related-to-impaired-glucose-metabolism-in-middle-aged-men-a-follow-up-of-the-northern-finland-birth-cohort-1966
#16
Nina Rautio, Tuulia Varanka-Ruuska, Eeva Vaaramo, Saranya Palaniswamy, Rozenn Nedelec, Jouko Miettunen, Jaro Karppinen, Juha Auvinen, Marjo-Riitta Järvelin, Sirkka Keinänen-Kiukaanniemi, Sylvain Sebert, Leena Ala-Mursula
AIMS: We explored whether registered unemployment is associated with impaired glucose metabolism in general population. METHODS: Based on Northern Finland Birth Cohort 1966 at 46 years, we analyzed the oral glucose tolerance tests of 1970 men and 2544 women in relation to their preceding three-year employment records in three categories of unemployment exposure: no (employed), low (≤1-year) and high exposure (>1-year). RESULTS: Among men, pre-diabetes was found in 19...
April 26, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28444534/metabolic-factors-anthropometric-measures-diet-and-physical-activity-in-long-term-breast-cancer-survivors-change-from-diagnosis-and-comparison-to-non-breast-cancer-controls
#17
Ana Elisa Lohmann, Marguerite Ennis, Sara K Taylor, Pamela J Goodwin
PURPOSE: We studied metabolic factors, diabetes, and anthropometric measurements at diagnosis and long-term follow-up (LTFU), mean 12.5 years post-diagnosis, in breast cancer (BC) survivors, and compared their status at LTFU to that of age-matched women without BC. Diet and physical activity were also assessed. METHOD: 535 non-diabetic BC patients treated at three University of Toronto hospitals were followed prospectively; 285 surviving patients, without distant recurrence, participated in a LTFU study...
April 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28438778/the-dual-amylin-and-calcitonin-receptor-agonist-kbp-042-works-as-adjunct-to-metformin-on-fasting-hyperglycaemia-and-hba1c-in-a-rat-model-of-type-2-diabetes
#18
Sara Toftegaard Hjuler, Sofie Gydesen, Kim Vietz Andreassen, Morten Asser Karsdal, Kim Henriksen
KBP-042 is a dual amylin and calcitonin receptor agonist which increases glucose tolerance and insulin action, and reduces body weight in rat models of obesity and pre-diabetes. The objective of the present study was to 1) Evaluate KBP-042 as a treatment of late stage type 2 diabetes in a rat model and 2) Assess the value of adding KBP-042 to the standard of care, metformin, in order to consider KBP-042 as a relevant drug for treating patients with type 2 diabetes. Two studies were included: an intervention and a prevention study...
April 24, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28435445/cardiometabolic-risk-factors-metabolic-syndrome-and-pre-diabetes-in-adolescents-in-the-sierra-region-of-ecuador
#19
Sharon L Casapulla, Cheryl A Howe, Gabriela Rosero Mora, Darlene Berryman, Mario J Grijalva, Edgar W Rojas, Masato Nakazawa, Jay H Shubrook
BACKGROUND: Excess weight (overweight and obesity) is the major modifiable risk factor for type 2 diabetes mellitus (T2DM) and other non-communicable diseases. However, excess weight may not be as predictive of diabetes risk as once thought. While excess weight and other obesity-related non-communicable diseases are of growing concern in low-middle income countries in Latin America, there is limited research on risk factors associated with T2DM in adolescents. This study investigated prevalence of overweight, obesity, prediabetes, diabetes and metabolic syndrome in adolescents in Ecuador...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28428013/-the-monophasic-pattern-in-oral-glucose-tolerance-test-as-a-predictive-risk-factor-of-type-2-diabetes-in-obese-paediatric-patients
#20
Aura D Herrera-Martínez, Patricia Enes, María Martín-Frías, Belén Roldán, Rosa Yelmo, Raquel Barrio
INTRODUCTION: The onset of obesity at young ages is strongly associated with the early development of type 2diabetes (T2D). The shape of the curves of glucose and insulin curves during an oral glucose tolerance test (OGTT) could predict the risk of developing T2D. OBJECTIVE: To analyse the morphology of the OGTT and determine T2D risk factors in a mainly Caucasian population of children and adolescents. METHODS: Observational retrospective study including 588 patients (309 males, 279 females) with a mean age of 11...
April 17, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
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