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https://www.readbyqxmd.com/read/28091589/platelet-monocyte-and-neutrophil-activation-and-glucose-tolerance-in-south-african-mixed-ancestry-individuals
#1
Glenda M Davison, Bongani B Nkambule, Zibusiso Mkandla, Gloudina M Hon, Andre P Kengne, Rajiv T Erasmus, Tandi E Matsha
Platelet activation has been described in patients with chronic inflammation, however in type 2 diabetes mellitus it remains controversial. We compared levels of platelet leucocyte aggregates, monocyte and granulocyte activation across glucose tolerance statuses in mixed ancestry South Africans. Individuals (206) were recruited from Bellville-South, Cape Town, and included 66% with normal glucose tolerance, 18.7% pre-diabetes, 8.7% screen-detected diabetes and 6.3% known diabetes. Monocyte and neutrophil activation were measured by calculating the percentage of cells expressing CD142 and CD69 while platelet monocyte aggregates were defined as CD14(++) CD42b(+) events and platelet neutrophil aggregates as CD16(++) CD42b(+) events...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057658/pioglitazone-and-cardiovascular-outcomes-in-patients-with-insulin-resistance-pre-diabetes-and-type-2-diabetes-a-systematic-review-and-meta-analysis
#2
Hung-Wei Liao, Jeffrey L Saver, Yi-Ling Wu, Tso-Hsiao Chen, Meng Lee, Bruce Ovbiagele
OBJECTIVES: To evaluate the effect of pioglitazone in people with insulin resistance, pre-diabetes and type 2 diabetes. DESIGN AND SETTING: Systematic review and meta-analysis of randomised, controlled trials. DATA SOURCES: Literature searches were performed across PubMed, EMBASE, MEDLINE and Cochrane Central Register of Controlled Trials from 1966 to May 2016 to identify randomised, controlled trials with more than 1 year follow-up. OUTCOME MEASURES: Relative risk (RR) with 95% CI was used to evaluate the association between pioglitazone and the risk of major adverse cardiovascular events (MACE: composite of non-fatal myocardial infarction, non-fatal stroke and cardiovascular death) and safety outcomes, after pooling data across trials in a fixed-effects model...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28052845/efficacy-and-effectiveness-of-screen-and-treat-policies-in-prevention-of-type-2-diabetes-systematic-review-and-meta-analysis-of-screening-tests-and-interventions
#3
Eleanor Barry, Samantha Roberts, Jason Oke, Shanti Vijayaraghavan, Rebecca Normansell, Trisha Greenhalgh
OBJECTIVES:  To assess diagnostic accuracy of screening tests for pre-diabetes and efficacy of interventions (lifestyle or metformin) in preventing onset of type 2 diabetes in people with pre-diabetes. DESIGN:  Systematic review and meta-analysis. DATA SOURCES AND METHOD:  Medline, PreMedline, and Embase. Study protocols and seminal papers were citation-tracked in Google Scholar to identify definitive trials and additional publications...
January 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28049262/black-tea-consumption-improves-postprandial-glycemic-control-in-normal-and-pre-diabetic-subjects-a-randomized-double-blind-placebo-controlled-crossover-study
#4
Arisa Butacnum, Rewadee Chongsuwat, Akkarach Bumrungpert
BACKGROUND AND OBJECTIVES: Postprandial glycemic control is important for prevention of diabetes. Black tea consumption may improve postprandial glycemic control. The major bioactive compounds are polyphenols, black tea polymerized polyphenol (BTPP).This study examined the effect of black tea consumption on postprandial blood glucose and insulin response following sucrose loading in normal and pre-diabetes subjects. METHODS AND STUDY DESIGN: This study was a randomized, double-blind, placebo-controlled crossover study...
January 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28043586/assessment-of-diabetes-among-tuberculosis-patients-presenting-at-a-tertiary-care-facility-in-pakistan
#5
Muhammad Irfan, Naseem Salahuddin, Qamar Masood, Owais Ahmed, Umme Salama Moosajee, Zahra Hasan
OBJECTIVE/BACKGROUND: Pakistan ranks sixth among high-tuberculosis (TB)-burden countries worldwide and fifth worldwide for diabetes incidence. Although both these factors are independently known, the rate of diabetes among TB patients is not well known. We aimed to determine the prevalence of diabetes among patients with TB presenting at tertiary care health centers in Karachi, Pakistan. METHODS: A total of 216 patients with TB were recruited and their blood samples were taken for testing of glycosylated hemoglobin (HbA1c) and random blood sugar...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28025127/glucose-tolerance-and-insulin-sensitivity-are-impaired-in-app-ps1-transgenic-mice-prior-to-amyloid-plaque-pathogenesis-and-cognitive-decline
#6
Lauren Macklin, Chelsea M Griffith, Yan Cai, Gregory M Rose, Xiao-Xin Yan, Peter R Patrylo
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by beta-amyloid (Aβ) deposition, neurofibrillary tangles and cognitive decline. Clinical data suggests that both type 1 and type 2 diabetes are risk factors for AD-related dementia and several clinical studies have demonstrated that AD patients show alterations in peripheral glucose regulation characterized by insulin resistance (hyperinsulinemia) or hypoinsulinemia. Whether animal models of AD exhibit a pre-diabetic phenotype without additional dietary or experimental manipulation is unclear however, with contradictory data available...
December 23, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27992506/menstrual-cycle-irregularity-and-metabolic-disorders-a-population-based-prospective-study
#7
Marzieh Rostami Dovom, Fahimeh Ramezani Tehrani, Shirin Djalalinia, Leila Cheraghi, Samira Behboudi Gandavani, Fereidoun Azizi
The regularity of menstrual cycles is considered an indicator of women's reproductive health. Previous studies with a cross-sectional design have documented the relationship between menstrual cycle irregularities, insulin-resistance and the future risks for metabolic disorders. Limited data documented by prospective studies can lead to premature conclusions regarding the relationship between menstrual cycle irregularities and other conditions influencing women's health. The present study therefore, using a prospective design aimed to assess the risk of metabolic disorders in women with a history of irregular menstrual cycles, was based on the data gathered from the Tehran Lipid and Glucose study (TLGS) an ongoing prospective cohort study initiated in 1999...
2016: PloS One
https://www.readbyqxmd.com/read/27990781/sex-differences-endogenous-sex-hormone-hormones-sex-hormone-binding-globulin-shbg-and-exogenous-disruptors-in-diabetes-and-related-metabolic-outcomes
#8
Simin Liu, Qi Sun
In assessing clinical and pathophysiological development of type 2 diabetes (T2D), the critical role of the sex steroids axis is underappreciated particularly concerning the sex specific relations with many relevant cardiometabolic outcomes. In this issue of the Journal, we provide a comprehensive overview of these strong associations of germline variants in the genes governing the sex-steroids pathways, plasma levels of steroid-hormones, and sex hormone-binding globulin (SHBG) with T2D risk that have been observed in many clinical as well as high-quality large prospective cohorts of men and women across ethnic populations...
December 19, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27986405/an-elevated-1-h-post-load-glucose-level-during-the-oral-glucose-tolerance-test-detects-prediabetes
#9
Martin Buysschaert, Michael Bergman, Donald Yanogo, Ram Jagannathan, Benoit Buysschaert, Vanessa Preumont
AIM: The objective of the study was to compare the diagnosis of dysglycemic states by conventional oral glucose tolerance test (OGTT) criteria (fasting and 2-h plasma glucose) with the 1-h post-load plasma glucose level. MATERIAL AND METHODS: 34 individuals (mean age: 55±13years; BMI: 27.7±6.3kg/m(2)) at risk for prediabetes were administered a 75g OGTT. Individuals with normal glucose tolerance (NGT) or prediabetes were identified according to fasting and/or 2-h plasma glucose (PG) concentrations...
December 9, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27978601/cross-sectional-associations-of-impaired-glucose-metabolism-measures-with-bleeding-on-probing-and-periodontitis
#10
Cynthia M Pérez, Francisco Muñoz, Oelisoa M Andriankaja, Christine S Ritchie, Sasha Martínez, José Vergara, José Vivaldi, Lydia López, Maribel Campos, Kaumudi J Joshipura
AIM: This study assessed the associations of pre-diabetes and insulin resistance with bleeding on probing (BOP) and periodontitis among adults. MATERIALS AND METHODS: We included 1191 Hispanic adults aged 40-65 years, free of diabetes, enrolled in San Juan Overweight Adults Longitudinal Study. Pre-diabetes was defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or impaired glycated haemoglobin. Impaired one-hour plasma glucose (1hPG) was defined as levels >155 mg/dl...
December 15, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27965206/prior-lactation-reduces-future-diabetic-risk-through-sustained-post-weaning-effects-on-insulin-sensitivity
#11
Harpreet Bajaj, Chang Ye, Anthony J Hanley, Phil W Connelly, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
Breastfeeding ≥12 months is recommended for optimal infant nutrition but may hold maternal benefits, as well. Indeed, lactation has been associated with lower long-term risk of diabetes in the mother but the mechanism by which it imparts sustained post-weaning effects on glucose tolerance remains unclear. In this context, we postulated that lactation potentially could induce post-weaning beneficial effects on glucose tolerance by modifying the natural history of insulin sensitivity and/or pancreatic beta-cell function over time...
December 13, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27941737/challenges-in-hba1c-level-as-a-diagnostic-tool-of-diabetes-and-pre-diabetes-in-middle-aged-population-the-bangladesh-study
#12
A Begum, M A Muttalib, M N Arefin, M R Hoque, Z A Sheme, N Akter, U K Paul
Worldwide prevalence of diabetes is found to be the human health at an alarming rate. However, large numbers of patient remain undiagnosed. Oral glucose tolerance test (OGTT) still is regarded as gold standard in diagnosis of blood glucose abnormality. Although the less number of bodies are considering measurement of HbA1C as an alternate tool to identify risk group. This study was undertaken to evaluate the role of measurement of HbA1C in the diagnosis of diabetes and pre-diabetes in middle-aged Bangladeshi subjects and carried out in the department of Biochemistry, BIRDEM from July 2013 to June 2014...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27939935/catalase-deletion-promotes-prediabetic-phenotype-in-mice
#13
Claire Heit, Stephanie Marshall, Surrendra Singh, Xiaoqing Yu, Georgia Charkoftaki, Hongyu Zhao, David J Orlicky, Kristofer S Fritz, David C Thompson, Vasilis Vasiliou
Hydrogen peroxide is produced endogenously and can be toxic to living organisms by inducing oxidative stress and cell damage. However, it has also been identified as a signal transduction molecule. By metabolizing hydrogen peroxide, catalase protects cells and tissues against oxidative damage and may also influence signal transduction mechanisms. Studies suggest that acatalasemic individuals (i.e., those with very low catalase activity) have a higher risk for the development of diabetes. We now report catalase knockout (Cat(-/-)) mice, when fed a normal (6...
December 8, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27933750/comparing-glucose-and-hemoglobin-a1c-diagnostic-tests-among-a-high-metabolic-risk-hispanic-population
#14
Mónica A Vega-Vázquez, Margarita Ramirez-Vick, Francisco J Muñoz-Torres, Loida A González-Rodríguez, Kaumudi Joshipura
AIMS: Compare HbA1c diagnostic tests for pre-diabetes and diabetes with plasma glucose criteria (PGC), and compare the metabolic profiles of people classified by HbA1c versus by glucose levels. METHODS: Participants were recruited for the San Juan Overweight Adults Longitudinal Study (SOALS). Were primarily Hispanic (98%), without previously diagnosed diabetes, and aged 40-65 years. Participants classified as normal glycemic, pre-diabetes or diabetes based on baseline HbA1c and PGC, were compared with respect to baseline cardiometabolic factors...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27922820/rapamycin-treatment-benefits-glucose-metabolism-in-mouse-models-of-type-2-diabetes
#15
Peter C Reifsnyder, Kevin Flurkey, Austen Te, David E Harrison
Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. Here, we survey 5 mouse models of T2D (KK, KK-Ay, NONcNZO10, BKS-db/db, TALLYHO) to quantify effects of rapamycin on well-recognized markers of glucose homeostasis within a wide range of T2D environments...
November 30, 2016: Aging
https://www.readbyqxmd.com/read/27920944/comparing-obesity-related-health-disparities-among-native-hawaiians-pacific-islanders-asians-and-whites-in-california-reinforcing-the-need-for-data-disaggregation-and-operationalization
#16
Adrian Matias Bacong, Christina Holub, Liki Porotesano
Since the 2000 Census, Asians and Pacific Islanders have been categorized as separate races. Government initiatives have called for greater study of Asian, Native Hawaiian, and other Pacific Islander (NHPI) health outcomes. NHPI often have worse health outcomes than Asians and Whites. Despite this, the lack of operationalization of racial definitions may affect the magnitude of health disparities. This analysis examined how utilizing different sociological race definitions could influence NHPI health outcomes when compared to Asians and Whites...
November 2016: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/27918974/generational-change-in-fasting-glucose-and-insulin-among-children-at-ages-5-16y-modelled-on-the-earlybird-study-2015-and-uk-growth-standards-1990-earlybird-69
#17
Mohammod Mostazir, Alison Jeffery, Linda Voss, Terence Wilkin
AIM: Pre-diabetes is a state of beta-cell stress caused by excess demand for insulin. Body mass is an important determinant of insulin demand, and BMI has risen substantially over recent time. We sought to model changes in the parameters of glucose control against rising BMI over the past 25years. METHODS: Using random coefficient mixed models, we established the correlations between HbA1C, fasting glucose, fasting insulin, HOMA2-IR and BMI in contemporary (2015) children (N=307) at ages 5-16y from the EarlyBird study, and modelled their corresponding values 25years ago according to the distribution of BMI in the UK Growth Standards (1990)...
November 28, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27917464/relation-of-dysglycemia-to-structural-brain-changes-in-a-multiethnic-elderly-cohort
#18
Christiane Reitz, Vanessa A Guzman, Atul Narkhede, Charles DeCarli, Adam M Brickman, José A Luchsinger
OBJECTIVES: Abnormally high glucose levels (dysglycemia) increase with age. Epidemiological studies suggest that dysglycemia is a risk factor for cognitive impairment but the underlying pathophysiological mechanisms remain unclear. The objective of this study was to examine the relation of dysglycemia clinical categories (normal glucose tolerance (NGT), pre-diabetes, undiagnosed diabetes, known diabetes) with brain structure in older adults. We also assessed the relation between dysglycemia and cognitive performance...
December 5, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27914881/continuous-positive-airway-pressure-and-diabetes-risk-in-sleep-apnea-patients-a-systemic-review-and-meta-analysis
#19
Liang Chen, Jian Kuang, Jian-Hao Pei, Hong-Mei Chen, Zhong Chen, Zhong-Wen Li, Hua-Zhang Yang, Xiao-Ying Fu, Long Wang, Zhi-Jiang Chen, Shui-Qing Lai, Shu-Ting Zhang
BACKGROUND: The study assessed the effect of continuous positive airway pressure (CPAP) therapy on the risk of developing type 2 diabetes by evaluating change in the homeostasis model assessment of insulin resistance (HOMA-IR) fasting blood glucose (FBG) and fasting insulin following CPAP treatment in non-diabetic patients and pre-diabetic with obstructive sleep apnea (OSA). METHODS: Medline, PubMed, Cochrane, and EMBASE databases were searched until August 24, 2015...
November 30, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27913943/the-cost-effectiveness-of-interventions-targeting-lifestyle-change-for-the-prevention-of-diabetes-in-a-swedish-primary-care-and-community-based-prevention-program
#20
Anne Neumann, Lars Lindholm, Margareta Norberg, Olaf Schoffer, Stefanie J Klug, Fredrik Norström
BACKGROUND: Policymakers need to know the cost-effectiveness of interventions to prevent type 2 diabetes (T2D). The objective of this study was to estimate the cost-effectiveness of a T2D prevention initiative targeting weight reduction, increased physical activity and healthier diet in persons in pre-diabetic states by comparing a hypothetical intervention versus no intervention in a Swedish setting. METHODS: A Markov model was used to study the cost-effectiveness of a T2D prevention program based on lifestyle change versus a control group where no prevention was applied...
December 2, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
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