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https://www.readbyqxmd.com/read/28927413/erratum-to-changes-in-proteinuria-and-the-risk-of-myocardial-infarction-in-people-with-diabetes-or-pre-diabetes-a-prospective-cohort-study
#1
Anxin Wang, Yang Sun, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu, Xiuhua Guo
Following publication of the original article [1], the authors reported that figure 2 had not been replaced with the correct figure as indicated in the proofs.
September 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28927403/circulating-levels-and-characterization-of-microparticles-in-patients-with-different-degrees-of-glucose-tolerance
#2
Alessandra Giannella, Claudia Maria Radu, Lorenzo Franco, Elena Campello, Paolo Simioni, Angelo Avogaro, Saula Vigili de Kreutzenberg, Giulio Ceolotto
BACKGROUND: Microparticles (MPs) are vesicular structures shed from endothelial or circulating blood cells, after activation or apoptosis, and can be considered markers of vascular damage. We aimed to determine the levels of circulating MPs, their content of miRNA-126-3p and 5p, and their relationship with early endothelial activation/damage, in patients with different degree of glucose tolerance. METHODS: CD62E(+), CD62P(+), CD142(+), CD45(+) circulating MPs, their apoptotic (AnnexinV(+)) fractions, and miRNA-126 expression were determined in 39 prediabetic (PreDM), 68 type 2 diabetic (T2DM), and 53 control (NGT) subjects, along with main anthropometric and biochemical measurements...
September 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28926628/application-of-raman-spectroscopy-in-type-2-diabetes-screening-in-blood-using-leucine-and-isoleucine-amino-acids-as-biomarkers-and-in-comparative-anti-diabetic-drugs-efficacy-studies
#3
Zephania Birech, Peter Waweru Mwangi, Fredrick Bukachi, Keith Makori Mandela
Diabetes is an irreversible condition characterized by elevated blood glucose levels. Currently, there are no predictive biomarkers for this disease and the existing ones such as hemoglobin A1c and fasting blood glucose are used only when diabetes symptoms are noticed. The objective of this work was first to explore the potential of leucine and isoleucine amino acids as diabetes type 2 biomarkers using their Raman spectroscopic signatures. Secondly, we wanted to explore whether Raman spectroscopy can be applied in comparative efficacy studies between commercially available anti-diabetic drug pioglitazone and the locally used anti-diabetic herbal extract Momordica spinosa (Gilg...
2017: PloS One
https://www.readbyqxmd.com/read/28919328/c-peptide-levels-and-the-risk-of-diabetes-and-pre-diabetes-among-chinese-women-with-gestational-diabetes
#4
Ping Yin, Ping Shao, Huikun Liu, Weiqin Li, Leishen Wang, Jing Wang, Shuang Zhang, Junhong Leng, Nan Li, Huiguang Tian, Xilin Yang, Zhijie Yu, Gang Hu
AIMS: To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. METHODS: A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1-5years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. RESULTS: The multivariable-adjusted odds ratios based on different levels of C-peptide (0-33%, 34-66%, 67-90%, and >90% as C-peptide cutpoints) were 1...
August 17, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28912917/the-low-dose-7-5-mg-day-pioglitazone-therapy
#5
REVIEW
Hidekatsu Yanai, Hiroki Adachi
Pioglitazone is one of thiazolidinedione derivatives, which stimulates nuclear peroxisome proliferator-activated receptor gamma and improves glucose and lipid metabolism and insulin sensitivity. A recent systematic review and meta-analysis showed that pioglitazone therapy was associated with a lower risk of major adverse cardiovascular events in patients with pre-diabetes and diabetes. Further, in a cohort study of patients with type 2 diabetes, pioglitazone therapy was associated with a statistically significant decrease in the risk of all-cause mortality...
October 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28902697/effect-of-aloe-vera-on-glycemic-outcomes-in-patients-with-diabetes-mellitus-a-systematic-review-protocol
#6
Narabjit Kaur, Ritin Fernandez, Jenny Sim
The objective is to identify the effectiveness of Aloe vera on glycemic outcomes (fasting blood glucose level and glycosylated hemoglobin) in patients with diabetes mellitus. Specifically, the review question is: what is the effectiveness of oral A. vera (Aloe barbadensis) on glycemic outcomes in adult patients with pre-diabetes and type 2 diabetes mellitus as compared to a placebo group?
September 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28898934/the-associations-between-phthalate-exposure-and-insulin-resistance-%C3%AE-cell-function-and-blood-glucose-control-in-a-population-based-sample
#7
Robert Edgar Dales, Lisa Marie Kauri, Sabit Cakmak
In developed countries, phthalate exposure is ubiquitous. Previous studies have shown an association between phthalate levels and health effects. To test associations between phthalate exposures, estimated from urinary phthalate metabolites, and insulin resistance, β-cell function and glucose control. Data were obtained from a cross-sectional, nationally representative study; the Canadian Health Measures Survey (CHMS, 2009-2011). Participants under the age of 12, those with diabetes, who were pregnant or who had not fasted overnight were excluded...
September 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28898609/-diabetes-screening-in-patients-with-macrovascular-coronary-disease-are-the-new-european-guidelines-a-step-backwards
#8
Andreia Ribeiro, Sérgio Bravo Baptista, Mariana Faustino, Paulo Alves, Pedro Farto Abreu, Victor Machado Gil, Carlos Morais
BACKGROUND: The new European guidelines on diabetes mellitus and cardiovascular diseases propose that the FINnish Diabetes RIsk SCore should be used to evaluate the risk of diabetes mellitus and that diabetes mellitus screening in coronary artery disease patients should be based on fasting glucose and HbA1c. The 2 hour oral glucose tolerance test, recommended for all pts in the previous guidelines, is now only recommended for 'inconclusive' cases. We aimed to evaluate this new strategy...
June 30, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28894283/jinqijiangtang-tablets-for-pre-diabetes-a-randomized-double-blind-and-placebo-controlled-clinical-trial
#9
Hui Wang, Liping Guo, Hongcai Shang, Ming Ren, Xuemei Wang, Dehui Wang, Jianzong Chen, Shuanglei Li, Liming Chen, Yue Wang, Zhi Liu, Jingbo Zhai, Yuzhen Song, Hongbo Cao, Junhua Zhang, Chunxiang Liu, Xiao Sun, Da Huo, Wei Mu, Li Zhang, Wenke Zheng, Xiaoyan Yan, Chen Yao
This study observed the efficacy and safety of JinqiJiangtang tablets (JQJT tablets, a traditional Chinese patent medicine) for pre-diabetes. Four hundred patients with pre-diabetes at five centres were treated for 12months and followed for an additional 12months to investigate the preventative effects of JQJT tablets (Registration ID: ChiCTR-PRC-09000401). The incidence rate of diabetes mellitus was the primary endpoint. The risk of converting from pre-diabetes to diabetes was 0.58-fold less in the JQJT tablets group than in the placebo group [HR (95% CI): 0...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28885385/blood-pressure-variability-in-individuals-with-and-without-pre-diabetes-the-maastricht-study
#10
Tan Lai Zhou, Abraham A Kroon, Koen D Reesink, Miranda T Schram, Annemarie Koster, Nicolaas C Schaper, Pieter C Dagnelie, Carla J H van der Kallen, Simone J S Sep, Coen D A Stehouwer, Ronald M A Henry
OBJECTIVE: The mechanisms associating (pre)diabetes and cardiovascular disease (CVD) are incompletely understood. We hypothesize that greater blood pressure variability (BPV) may underlie this association, due to its association with (incident) CVD. Therefore, we investigated the association between (pre)diabetes and very short-term to mid-term BPV, that is within-visit, 24-h and 7-day BPV. METHODS: Cross-sectional data from The Maastricht Study [normal glucose metabolism (NGM), n = 1924; prediabetes, n = 511; type 2 diabetes mellitus (T2DM), n = 975; 51% men, aged 60 ± 8 years]...
September 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28878939/insulin-sensitive-and-insulin-resistant-obese-and-non-obese-phenotypes-role-in-prediction-of-incident-pre-diabetes-in-a-longitudinal-biracial-cohort
#11
Ibiye Owei, Nkiru Umekwe, Casey Provo, Jim Wan, Samuel Dagogo-Jack
OBJECTIVE: We measured insulin sensitivity with euglycemic clamp (Si-clamp) in initially normoglycemic African Americans (AA) and European Americans (EA), to probe the existence of subphenotypes of obesity and leanness, and their impact on incident dysglycemia during longitudinal follow-up. RESEARCH DESIGN AND METHODS: 320 healthy subjects (176 AA, 144 EA; mean age 44.2±10.6 years) underwent baseline assessments, including Si-clamp and homeostasis model of insulin resistance (HOMA-IR) and were stratified into: insulin-resistant obese (IRO) (body mass index (BMI) >30 kg/m(2), Si-clamp <0...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28878936/primary-care-physicians-utilization-of-type-2-diabetes-screening-guidelines-and-referrals-to-behavioral-interventions-a-survey-linked-retrospective-study
#12
Sandhya Mehta, Michelle Mocarski, Tami Wisniewski, Karin Gillespie, K M Venkat Narayan, Kathleen Lang
OBJECTIVE: To assess primary care physicians' (PCPs) knowledge of type 2 diabetes screening guidelines (American Diabetes Association (ADA) and 2008 US Preventive Services Task Force (USPSTF)), the alignment between their self-reported adherence and actual practice, and how often PCPs recommended diabetes prevention and self-management education programs (DPP/DSME). RESEARCH DESIGN AND METHODS: An online survey of PCPs to understand knowledge and adherence toward use of USPSTF/ADA guidelines and recommendation of DPP/DSME...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28869547/dietary-protein-and-amino-acid-profiles-in-relation-to-risk-of-dysglycemia-findings-from-a-prospective-population-based-study
#13
Parvin Mirmiran, Zahra Bahadoran, Saeed Esfandyari, Fereidoun Azizi
Considering the limited knowledge on the effects of dietary amino acid intake on dysglycemia, we assessed the possible association of dietary protein and amino acid patterns with the risk of pre-diabetes in a prospective population-based study. Participants without diabetes and pre-diabetes (n = 1878) were recruited from the Tehran Lipid and Glucose Study and were followed for a mean of 5.8 years. Their dietary protein and amino acid intakes were assessed at baseline (2006-2008); demographic, lifestyle, and biochemical variables were evaluated at baseline and in follow-up examinations...
September 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28868822/the-effectiveness-of-green-tea-or-green-tea-extract-on-insulin-resistance-and-glycemic-control-in-type-2-diabetes-mellitus-a-meta-analysis
#14
REVIEW
Jinyue Yu, Peige Song, Rachel Perry, Chris Penfold, Ashley R Cooper
Green tea or green tea extract (GT/GTE) has been demonstrated to reduce insulin resistance and improve glycemic control. However, evidence for this health beneficial effect is inconsistent. This systematic review evaluated the effect of GT/GTE on insulin resistance and glycemic control in people with pre-diabetes/type 2 diabetes mellitus (T2DM). Ovid MEDLINE, Embase, AMED, Web of Science, and the Cochrane Library were searched up to April 2017 for randomised controlled trials of participants with pre-diabetes or T2DM, where the intervention was GT/GTE...
August 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28864708/does-supplementation-with-carnosine-improve-cardiometabolic-health-and-cognitive-function-in-patients-with-pre-diabetes-and-type-2-diabetes-study-protocol-for-a-randomised-double-blind-placebo-controlled-trial
#15
Estifanos Baye, Kirthi Menon, Maximilian Pj de Courten, Arul Earnest, James Cameron, Barbora de Courten
INTRODUCTION: Carnosine, an over-the-counter food supplement, has a promising potential for the prevention and treatment of chronic diseases such as type 2 diabetes (T2DM), cardiovascular and neurodegenerative diseases through its anti-inflammatory, antiglycation, antioxidative and chelating effects. We have previously shown that supplementation with carnosine preserves insulin sensitivity and secretion in non-diabetic overweight and obese individuals. The effect of carnosine on cardiometabolic risk and related cognitive outcomes in patients with pre-diabetes and T2DM has thus far not been studied...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28861867/urine-glucose-levels-are-disordered-before-blood-glucose-level-increase-was-observed-in-zucker-diabetic-fatty-rats
#16
Wei Yin, Weiwei Qin, Youhe Gao
Many patients with diabetes are not diagnosed at all or are diagnosed too late to be effectively treated, resulting in nonspecific symptoms and a long period of incubation of the disease. Pre-diabetes is an early warning signal of diabetes, and the change of urine glucose in this period has been ignored even though urine has long been related with diabetes. In this study, Zucker diabetic fatty (ZDF) rats were used to test if there were changes in urine glucose before blood glucose increases. Six 8-week-old male ZDF rats (fa/fa) and Zucker lean (ZL) rats (fa/+) were fed with Purina 5008 high-fat diet and tested for fasting blood glucose and urine glucose...
August 29, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28843031/diabetes-primary-prevention-program-new-insights-from-data-analysis-of-recruitment-period
#17
Juan J Gagliardino, Jorge F Elgart, Marcelo Bourgeois, Graciela Etchegoyen, Gabriel Fantuzzi, Matías Ré, Juan P Ricart, Silvia García, Cecilia Giampieri, Lorena González, Florencia Suárez-Crivaro, Peter Kronsbein, Julieta M Angelini, Camilo Martínez, Jorge Martínez, Alberto Ricart, Eduardo Spinedi
OBJECTIVES: Primary Prevention of Diabetes Program in Buenos Aires Province (PPDBA) evaluates the effectiveness of adopting healthy lifestyle to prevent type 2 diabetes (T2D) in people at high risk of developing it. We aimed to present preliminary data analysis of FINDRISC and laboratory measurements taken during recruitment of people for the PPDBA in the cities of La Plata, Berisso and Ensenada, Argentina. METHODS: People were recruited through: Population approach (house to house survey by FINDRISC in randomized areas) and opportunistic approach (FINDRISC completed by participants during consultations for non-related pre-diabetes/diabetes symptoms in public and private primary care centers of cities involved)...
August 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28842399/inhibition-of-12-15-lipoxygenase-protects-against-%C3%AE-cell-oxidative-stress-and-glycemic-deterioration-in-mouse-models-of-type-1-diabetes
#18
Marimar Hernandez-Perez, Gaurav Chopra, Jonathan Fine, Abass M Conteh, Ryan M Anderson, Amelia K Linnemann, Chanelle Benjamin, Jennifer B Nelson, Kara S Benninger, Jerry L Nadler, David J Maloney, Sarah A Tersey, Raghavendra G Mirmira
Islet β-cell dysfunction and aggressive macrophage activity are early features in the pathogenesis of type 1 diabetes (T1D). 12/15-lipoxygenase (12/15-LOX) is induced in β cells and macrophages during T1D and produces pro-inflammatory lipids and lipid peroxides that exacerbate β-cell dysfunction and macrophage activity. Inhibition of 12/15-LOX provides a potential therapeutic approach to prevent glycemic deterioration in T1D. Two inhibitors recently identified by our groups through screening efforts, ML127 and ML351, have been shown to selectively target 12/15-LOX with high potency...
August 25, 2017: Diabetes
https://www.readbyqxmd.com/read/28842165/chronic-kidney-disease-basal-insulin-glargine-and-health-outcomes-in-people-with-dysglycemia-the-origin-study
#19
Vasilios Papademetriou, Eric S Nylen, Michael Doumas, Jeff Probstfield, Johannes F E Mann, Richard E Gilbert, Hertzel C Gerstein
BACKGROUND: Early stages of chronic kidney disease are associated with an increased cardiovascular risk in patients with established type 2 diabetes and macrovascular disease. The role of early stages of chronic kidney disease on macrovascular outcomes in prediabetes and early type two diabetes mellitus is not known. In the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial, the introduction of insulin had no effect on cardiovascular outcomes compared to standard therapy...
August 22, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28838898/protocol-for-a-pilot-randomised-controlled-trial-of-metformin-in-pre-diabetes-after-kidney-transplantation-the-transplantation-and-diabetes-transdiab-study
#20
Basil Alnasrallah, Helen Pilmore, Paul Manley
INTRODUCTION: Post-transplant diabetes mellitus (PTDM) is a common complication of kidney transplantation and is associated with significant morbidity and mortality. In the general population, metformin has been used for diabetes prevention in high-risk individuals. Improving insulin sensitivity is one of many proven favourable effects of metformin. Despite the high incidence of PTDM in kidney transplant recipients, there is a lack of evidence for the role of metformin in the prevention of diabetes in this setting...
August 23, 2017: BMJ Open
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