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Pre-diabetes

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https://www.readbyqxmd.com/read/28238331/prognostic-value-of-blood-glucose-in-emergency-room-and-glycosylated-hemoglobin-in-patients-who-have-suffered-an-acute-cerebro-vascular-event
#1
Ander Ernaga Lorea, María Cecilia Hernández Morhain, María Dolores Ollero García-Agulló, Juan Pablo Martínez de Esteban, Ana Iriarte Beroiz, Jaime Gállego Culleré
BACKGROUND AND OBJECTIVE: Stress hyperglycemia has been associated with a worse prognosis in patients hospitalized in critical care units. The aim of this study is to evaluate the impact of blood glucose and glycosylated hemoglobin (HbA1c) levels on the mortality of patients suffering a acute cerebro-vascular event, and to determine if this relationship depends on the presence of diabetes. MATERIAL AND METHODS: A retrospective analysis of 255 patients admitted to the ER for stroke was performed...
February 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28218739/suppression-of-islet-homeostasis-protein-thwarts-diabetes-mellitus-progression
#2
Seh-Hoon Oh, Marda L Jorgensen, Clive H Wasserfall, Altin Gjymishka, Bryon E Petersen
During progression to type 1 diabetes, insulin-producing β-cells are lost through an autoimmune attack resulting in unrestrained glucagon expression and secretion, activation of glycogenolysis, and escalating hyperglycemia. We recently identified a protein, designated islet homeostasis protein (IHoP), which specifically co-localizes within glucagon-positive α-cells and is overexpressed in the islets of both post-onset non-obese diabetic (NOD) mice and type 1 diabetes patients. Here we report that in the αTC1...
February 20, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28213010/the-pathogenesis-and-pathophysiology-of-gestational-diabetes-mellitus-deductions-from-a-three-part-longitudinal-metabolomics-study-in-china
#3
REVIEW
Kai P Law, Hua Zhang
Gestational diabetes mellitus (GDM) is a form of diabetes that is first recognised during pregnancy, with no evidence of pre-existing type 1 or type 2 diabetes. The prevalence of GDM has been rising steadily over the past few decades, coinciding with the ongoing epidemic of obesity and type 2 diabetes. Although GDM normally disappears after delivery, women who have been previously diagnosed with GDM are at a greater risk of developing gestational diabetes in subsequent pregnancies, and type 2 diabetes later in life...
February 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28212346/the-relationship-between-physical-activity-and-plasma-glucose-level-amongst-ellisras-rural-young-adult-males-and-females-ellisras-longitudinal-study
#4
Moloko Matshipi, Kotsedi Daniel Monyeki, Han Kemper
Unhealthy lifestyle characteristics such as low physical activity (PA) and high plasma glucose levels (PGLs) may lead to the development of type 2 diabetes mellitus in adulthood. The aim of this study was to investigate (i) the level of physical activity; (ii) the prevalence of pre-diabetes and (iii) the relationship between PA and plasma glucose level in a rural Ellisras adult population aged 18 to 28 years. A total of 713 young adults (349 males and 364 females) who took part in the Ellisras Longitudinal Study participated in the study...
February 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28198145/secular-and-race-ethnic-trends-in-glycemic-outcomes-by-bmi-in-us-adults-the-role-of-waist-circumference
#5
Sandra S Albrecht, Elizabeth Mayer-Davis, Barry M Popkin
BACKGROUND: For the same BMI level, waist circumference (WC) is higher in more recent years. How this impacts diabetes and pre-diabetes prevalence in the US and for different race/ethnic groups is unknown. We examined prevalence differences diabetes and pre-diabetes by BMI over time, investigated whether estimates were attenuated after adjusting for WC, and evaluated implications of these patterns on race/ethnic disparities in glycemic outcomes. METHODS: Data came from 12,614 participants aged 20-74 years from the National Health and Nutrition Examination Surveys (1988-1994; 2007-2012)...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28192103/endoscopic-bariatric-and-metabolic-therapies-new-and-emerging-technologies
#6
Shelby Sullivan, Steven A Edmundowicz, Christopher C Thompson
Endoscopic Bariatric and Metabolic Therapies (EBMT) are a new addition to the treatment arsenal for obesity. These include devices which are placed or removed via flexible endoscopy, and procedures which utilize instruments that require flexible endoscopy for the indications of weight loss or treatment of glucose intolerance (from pre-diabetes to diabetes). The EBMTs are generally divided into gastric and small bowel categories, and although individual EBMTs may have unique mechanisms of action, similar themes in proposed mechanism of action are seen in the gastric and small bowel EBMTs respectively...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28178934/the-prevalence-and-incidence-of-frailty-in-pre-diabetic-and-diabetic-community-dwelling-older-population-results-from-beijing-longitudinal-study-of-aging-ii-blsa-ii
#7
Jagadish Kumar Chhetri, Zheng Zheng, Xitong Xu, Cuihong Ma, Piu Chan
BACKGROUND: Various factors including cardio-metabolic disorders are found to be correlated with frailty. With the increase in age, older adults are likely to have elevated blood glucose level. In this study we intend to investigate the prevalence and incidence of frailty in the pre-diabetic and diabetic community dwelling elderly population and the associated risk factors. METHODS: At baseline total of 10,039 subjects with a mean age of 70.51 (±7.82) were included...
February 8, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28177734/association-between-dietary-inflammatory-index-dii-and-risk-of-pre-diabetes-a-case-control-study
#8
Farhad Vahid, Nitin Shivappa, Mohsen Karamati, Alireza Jafari Naeini, James R Hebert, Sayed Hossein Davoodi
BACKGROUND: The possible relationship between diet-related inflammation and the risk of pre-diabetes requires further investigation, especially in non-Western populations. We examined the ability of the dietary inflammatory index (DII) to predict the risk of pre-diabetes in a case-control study conducted at specialized centers in Esfahan, Iran. METHODS: A total of 214 incident cases of pre-diabetes were selected with the non-random sampling procedure; and 200 controls randomly selected from the same clinics were frequency-matched on age (±5 years) and sex...
December 15, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177591/insulin-effect-on-hearing-recovery-in-idiopathic-sudden-sensorineural-hearing-loss-retrospective-study-of-145-patients
#9
O H Ryu, J R Chao, M G Choi, C Kim, J-G Suh, Y Y Kim, C H Park, H-J Kim, J H Lee
1.We compared the hearing results of idiopathic sudden sensorineural hearing loss (ISSNHL) in normoglycemic patients versus those with pre-diabetes and diabetes mellitus (DM), including demographics and the impact of insulin administration. 2.The success rate for return of hearing in patients with DM was very high (80.0%) contrary to very low success rate for patients with pre-diabetes (38.2%). 3.High SD and MAGE in DM group could be explained by the effect of insulin and steroid treatment. 4.We believe the best explanation for the salutary impact of administration of insulin on hearing return was through reversal of ischemia 5...
February 8, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28164494/the-blood-bank-for-diabetes-screening-a-feasible-alternative
#10
Mauren I Anghebem-Oliveira, Claudia D Costa, Giorgio R Baldanzi, Juliane C Schmitt-Mansur, Geraldo Picheth, Fabiane G M Rego
BACKGROUND: Vascular complications of diabetes mellitus (DM) are associated with 5% of deaths globally every year. Early diagnosis and treatment could reduce this figure. The aim of this project was to investigate the frequency of undiagnosed DM among blood donors and the possibility of blood banks participating in DM screening. METHODS: Of the approximate 5,600 candidates for blood donation who were evaluated, 4,601 were considered suitable. Candidates with any type of DM, hypertension, thyroid disease, and/or continuous use of any drugs were excluded, resulting in the participation of 635 donors aged 18 - 69 years...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28159442/does-patient-activation-predict-the-course-of-type-2-diabetes-a-longitudinal-study
#11
Rebecca M Sacks, Jessica Greene, Judith Hibbard, Valerie Overton, Carmen D Parrotta
OBJECTIVE: To examine whether patient activation is predictive of the course of diabetes over a three year period among patients with and without diabetes. METHODS: Longitudinal analyses utilized electronic health record data from 2011 to 2014. We examined how the patient activation measure (PAM) was predictive of 2014 diabetes-related outcomes among patients with diabetes (n=10,071); pre-diabetes (n=1804); and neither diabetes nor pre-diabetes (n=46,402). Outcomes were clinical indicators (blood pressure, cholesterol, and trigylcerides), costly utilization, and progression from no diabetes to pre-diabetes or diabetes...
January 25, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28154203/metformin-accumulation-correlates-with-organic-cation-transporter-2-protein-expression-and-predicts-mammary-tumor-regression-in-vivo
#12
L Allyson Checkley, Michael C Rudolph, Elizabeth A Wellberg, Erin D Giles, Reema S Wahdan-Alaswad, Julie A Houck, Susan M Edgerton, Ann D Thor, Pepper Schedin, Steven M Anderson, Paul S MacLean
Several epidemiologic studies have associated metformin treatment with a reduction in breast cancer incidence in prediabetic and type II diabetic populations. Uncertainty exists regarding which patient populations and/or tumor subtypes will benefit from metformin treatment, and most preclinical in vivo studies have given little attention to the cellular pharmacology of intratumoral metformin uptake. Epidemiologic reports consistently link western-style high fat diets (HFD), which drive overweight and obesity, with increased risk of breast cancer...
February 2, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28150914/proteomic-analysis-of-serum-biomarkers-for-pre-diabetes-using-the-lea-rat-a-spontaneous-animal-model-of-type-2-diabetes-mellitus
#13
Eri Takahashi, Hiroyuki Unoki-Kubota, Yukiko Shimizu, Tadashi Okamura, Wakiko Iwata, Hiroshi Kajio, Ritsuko Yamamoto-Honda, Tomoko Shiga, Shigeo Yamashita, Kazuyuki Tobe, Akinori Okumura, Michihiro Matsumoto, Kazuki Yasuda, Mitsuhiko Noda, Yasushi Kaburagi
AIM: To identify candidate serum molecules associated with the progression of type 2 diabetes mellitus (T2DM), differential serum proteomic analysis was performed on a spontaneous animal model of T2DM without obesity, the Long-Evans Agouti (LEA) rat. MATERIALS AND METHODS: We performed quantitative proteomic analysis using serum samples from 8- and 16-week-old LEA and control Brown Norway (BN) rats (n=4/group). Differentially expressed proteins were validated by multiple reaction monitoring (MRM) analysis using the sera collected from 8-, 16- and 24-week-old LEA (n = 4/each group) and BN rats [n = 5/each group]...
February 2, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28137793/increase-in-pancreatic-proinsulin-and-preservation-of-beta-cell-mass-in-autoantibody-positive-donors-prior-to-type-1-diabetes-onset
#14
Teresa Rodriguez-Calvo, Jose Zapardiel-Gonzalo, Natalie Amirian, Ericka Castillo, Yasaman Lajevardi, Lars Krogvold, Knut Dahl-Jørgensen, Matthias G von Herrath
Type 1 diabetes is characterized by the loss of insulin production due to beta cell dysfunction and/or destruction. The hypothesis that beta cell loss occurs early during the pre-diabetic phase has recently been challenged. Here we show, for the first time in situ that in pancreas sections from autoantibody positive donors (Ab+) insulin area and beta cell mass are maintained prior to disease onset, and that production of proinsulin increases. This suggests that beta cell destruction occurs more precipitously than previously assumed...
January 30, 2017: Diabetes
https://www.readbyqxmd.com/read/28137482/epigallocatechin-3-gallate-egcg-activates-ampk-through-the-inhibition-of-glutamate-dehydrogenase-in-muscle-and-pancreatic-%C3%A3-cells-a-potential-beneficial-effect-in-the-pre-diabetic-state
#15
Shirin Pournourmohammadi, Mariagrazia Grimaldi, Malin H Stridh, Vanessa Lavallard, Helle S Waagepetersen, Claes B Wollheim, Pierre Maechler
Glucose homeostasis is determined by insulin secretion from the ß-cells in pancreatic islets and by glucose uptake in skeletal muscle and other insulin target tissues. While glutamate dehydrogenase (GDH) senses mitochondrial energy supply and regulates insulin secretion, its role in the muscle has not been elucidated. Here we investigated the possible interplay between GDH and the cytosolic energy sensing enzyme 5'-AMP kinase (AMPK), in both isolated islets and myotubes from mice and humans. The green tea polyphenol epigallocatechin-3-gallate (EGCG) was used to inhibit GDH...
January 27, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28137307/dysglycemia-associations-with-adipose-tissue-among-hiv-infected-patients-after-2-years-of-antiretroviral-therapy-in-mwanza-a-follow-up-cross-sectional-study
#16
George PrayGod, John Changalucha, Saidi Kapiga, Robert Peck, Jim Todd, Suzanne Filteau
BACKGROUND: Data on the burden of dysglycemia among HIV-infected patients on antiretroviral therapy (ART) in Africa are limited. We determined the prevalence of pre-diabetes and diabetes among HIV-infected patients who started ART when malnourished 2 to 3 years previously and investigated the association of dysglycemia with body composition. METHODS: Malnourished (body mass index (BMI) < 18.5 kg/m(2)) HIV-infected patients who were enrolled in the Nutritional Support for Africans Starting Antiretroviral Therapy (NUSTART) trial from 2011 to 2013 were followed-up from March to August 2015...
January 30, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28131651/type-2-diabetes-and-its-correlates-in-a-first-nationwide-study-among-cypriot-adults
#17
Eleni Andreou, Dimitrios Papandreou, Photos Hajigeorgiou, Katia Kyriakou, Thalia Avraam, Georgia Chappa, Procopis Kallis, Christalleni Lazarou, Christiana Philippou, Christoforos Christoforou, Rebecca Kokkinofta, Christos Dioghenous, Savvas Savva, Antony Kafatos, Antonios Zampelas
Obesity rates in Cyprus are very high and epidemiological information on type 2 diabetes mellitus is limited. The correlates of type 2 diabetes among adults remain unknown in the Cypriot population. Thus, the purpose of this study is to provide the first national estimate of the prevalence of type 2 diabetes and investigate its correlates. A randomly stratified nationally sample of 1001 adults aged 18-80 participated in the study. Only 950 subjects completed the study. All subjects were free of any diseases (known diabetes, kidney, liver), medication and supplementation...
January 25, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28130199/dynamics-of-diabetes-and-obesity-epidemiological-perspective
#18
REVIEW
Annette Boles, Ramesh Kandimalla, P Hemachandra Reddy
The purpose of this review article is to understand the current literature on obesity, diabetes and therapeutic avenues across the world. Diabetes is a chronic lifestyle condition that affects millions of people worldwide and it is a major health concern in our society. Diabetes and obesity are associated with various conditions, including non-modifiable and modifiable risk factors. Early detectable markers are not well established to detect pre-diabetes and as a result, it becomes diabetes. Several published epidemiological studies were assessed and the findings were summarized...
January 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28128316/six-year-changes-in-the-prevalence-of-obesity-and-obesity-related-diseases-in-northeastern-china-from-2007-to-2013
#19
Jing Wu, Hongqin Xu, Xiuting He, Yi Yuan, Chunyan Wang, Jie Sun, Shumei He, Junqi Niu
Obesity and obesity-related diseases are important public health challenges. In this study, we aimed to provide updated trends in the prevalence of these conditions. We conducted two independent cross-sectional surveys of the general population aged 20-75 years in 2007 and 2013 in Jilin, China. A total of 3636 (1719 males) and 1359 (602 males) participants were enrolled in the 2007 and 2013 surveys, respectively. Obesity-related diseases were defined as type 2 diabetes, hypertension, dyslipidemia and non-alcoholic fatty liver disease (NAFLD)...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28127405/prevalence-and-risk-factors-of-diabetes-in-a-large-community-based-study-in-north-india-results-from-a-steps-survey-in-punjab-india
#20
Jaya Prasad Tripathy, J S Thakur, Gursimer Jeet, Sohan Chawla, Sanjay Jain, Arnab Pal, Rajendra Prasad, Rajiv Saran
AIMS: India is the diabetes capital with home to 69.1 million people with DM, the second highest number of cases after China. Recent epidemiological evidence indicates a rising DM epidemic across all classes, both affluent and the poor in India. This article reports on the prevalence of diabetes and pre-diabetes in the North Indian state of Punjab as part of a large household NCD Risk Factor Survey. METHODS: A household NCD STEPS survey was done in the state of Punjab, India in a multistage stratified sample of 5127 individuals...
2017: Diabetology & Metabolic Syndrome
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