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https://www.readbyqxmd.com/read/28645281/sex-difference-in-the-risk-for-exercise-induced-albuminuria-correlates-with-hemoglobin-a1c-and-abnormal-exercise-ecg-test-findings
#1
Rafael Y Brzezinski, Inbal Etz-Hadar, Ayelet Grupper, Michal Ehrenwald, Itzhak Shapira, David Zeltser, Shlomo Berliner, Ori Rogowski, Roy Eldor, Shani Shenhar-Tsarfaty
BACKGROUND: Albuminuria is an established marker for endothelial dysfunction and cardiovascular risk in diabetes and prediabetes. Exercise induced albuminuria (EiA) appears earlier and may be a more sensitive biomarker for renal endothelial damage. We sought to examine the association between EiA, parameters of the metabolic syndrome, A1C levels, exercise ECG test results and sex related differences in a large cohort of healthy, pre-diabetic and diabetic subjects. METHODS: A total of 3029 participants from the Tel-Aviv Medical Center Inflammation Survey cohort (mean age 46 years, 73% men) were analyzed...
June 23, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28640857/glucose-dysregulation-and-response-to-common-anti-diabetic-agents-in-the-fatzo-pco-mouse
#2
Richard G Peterson, Charles Van Jackson, Karen M Zimmerman, Jorge Alsina-Fernandez, M Dodson Michael, Paul J Emmerson, Tamer Coskun
The FATZO/Pco mouse is the result of a cross of the C57BL/6J and AKR/J strains. The crossing of these two strains and the selective inbreeding for obesity, insulin resistance and hyperglycemia has resulted in an inbred strain exhibiting obesity in the presumed presence of an intact leptin pathway. Routinely used rodent models for obesity and diabetes research have a monogenic defect in leptin signaling that initiates obesity. Given that obesity and its sequelae in humans are polygenic in nature and not associated with leptin signaling defects, the FATZO mouse may represent a more translatable rodent model for study of obesity and its associated metabolic disturbances...
2017: PloS One
https://www.readbyqxmd.com/read/28638091/the-cannabinoid-ligand-lh-21-reduces-anxiety-and-improves-glucose-handling-in-diet-induced-obese-pre-diabetic-mice
#3
Silvana Y Romero-Zerbo, Inmaculada Ruz-Maldonado, Vanesa Espinosa-Jiménez, Alex Rafacho, Ana I Gómez-Conde, Lourdes Sánchez-Salido, Nadia Cobo-Vuilleumier, Benoit R Gauthier, Francisco J Tinahones, Shanta J Persaud, Francisco J Bermúdez-Silva
LH-21 is a triazol derivative that has been described as a low-permeant neutral CB1 antagonist, though its pharmacology is still unclear. It has been associated with anti-obesity actions in obese rats. However, its role in preventing type 2 diabetes (T2D) onset have not been studied yet. Given CB1 receptors remain as potential pharmacological targets to fight against obesity and T2D, we wanted to explore the metabolic impact of this compound in an animal model of obesity and pre-diabetes as well as the lack of relevant actions in related central processes such as anxiety...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632180/preview-prevention-of-diabetes-through-lifestyle-intervention-and-population-studies-in-europe-and-around-the-world-design-methods-and-baseline-participant-description-of-an-adult-cohort-enrolled-into-a-three-year-randomised-clinical-trial
#4
Mikael Fogelholm, Thomas Meinert Larsen, Margriet Westerterp-Plantenga, Ian Macdonald, J Alfredo Martinez, Nadka Boyadjieva, Sally Poppitt, Wolfgang Schlicht, Gareth Stratton, Jouko Sundvall, Tony Lam, Elli Jalo, Pia Christensen, Mathijs Drummen, Elizabeth Simpson, Santiago Navas-Carretero, Teodora Handjieva-Darlenska, Roslyn Muirhead, Marta P Silvestre, Daniela Kahlert, Laura Pastor-Sanz, Jennie Brand-Miller, Anne Raben
Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated...
June 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28619690/metformin-the-aspirin-of-the-21-st-century-its-role-in-gestational-diabetes-prevention-of-preeclampsia-and-cancer-and-the-promotion-of-longevity
#5
REVIEW
Roberto Romero, Offer Erez, Maik Hüttemann, Eli Maymon, Bogdan Panaitescu, Agustin Conde-Agudelo, Percy Pacora, Bo Hyun Yoon, Lawrence I Grossman
Metformin is everywhere. Originally introduced in clinical practice as an anti-diabetic agent, its role as a therapeutic agent is expanding to include treatment of pre-diabetes, gestational diabetes, polycystic ovarian disease, and more recently, experimental studies, as well as observations in randomized clinical trials, suggest that metformin could have a place in the treatment or prevention of preeclampsia. This article provides a brief overview of the history of metformin in the treatment of diabetes, reviews the results of meta-analyses of metformin in gestational diabetes, and the treatment of obese non-diabetic pregnant women to prevent macrosomia...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28606902/prevalence-clinical-features-and-risk-assessment-of-pre-diabetes-in-spain-the-prospective-mollerussa-cohort-study
#6
María Belén Vilanova, Mireia Falguera, Josep Ramon Marsal, Esther Rubinat, Núria Alcubierre, Esmeralda Catelblanco, Minerva Granado-Casas, Neus Miró, Àngels Molló, Manel Mata-Cases, Josep Franch-Nadal, Didac Mauricio
PURPOSE: The Mollerussa prospective cohort was created to study pre-diabetes in a population-based sample from the primary care setting in the semirural area of Pla d'Urgell in Catalonia (Spain). The aims of the study were to assess the prevalence of pre-diabetes in our population, the likelihood to develop overt diabetes over time and to identify risk factors associated with the progression of the condition. PARTICIPANTS: The cohort includes 594 subjects randomly selected between March 2011 and July 2014 from our primary care population, who were older than 25 years, consented to participate and did not have a recorded diagnosis of diabetes...
June 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28601890/risk-score-for-detecting-dysglycemia-a-cross-sectional-study-of-a-working-age-population-in-an-oil-field-in-china
#7
Xiubiao Tian, Yan Liu, Ying Han, Jieli Shi, Tiehong Zhu
BACKGROUND Dysglycemia (pre-diabetes or diabetes) in young adults has increased rapidly. However, the risk scores for detecting dysglycemia in oil field staff and workers in China are limited. This study developed a risk score for the early identification of dysglycemia based on epidemiological and health examination data in an oil field working-age population with increased risk of diabetes. MATERIAL AND METHODS Multivariable logistic regression was used to develop the risk score model in a population-based, cross-sectional study...
June 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28601102/food-insecurity-and-pre-diabetes-in-adults-race-ethnic-and-sex-differences
#8
Rosenda Murillo, Layton M Reesor, Claudia W Scott, Daphne C Hernandez
OBJECTIVE: We examined sex and race/ethnicity differences in the association between food insecurity status and prediabetes among adults. METHOD: We used cross-sectional 2011 and 2012 National Health Interview Survey data on non-Hispanic white, non-Hispanic black, and Hispanic adults aged 18-59 years whose household income was ≤ 299% Federal Poverty Line (N = 19,048). Food insecurity status was determined by 3 or more affirmative responses on the 10-item USDA Food Security Scale...
July 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/28591506/-persists-the-controversy-concerning-the-rutinary-use-of-diagnostic-tests-in-asymptomatic-persons
#9
Arturo Zárate, Marcelino Hernández-Valencia, Lourdes Basurto, Renata Saucedo
Currently, in medicine there is an environment replete with controversy and debate, partially due to the popular concept Evidence-Based Medicine, and to the development of technological advances and, apparently, better therapeutic resources. This has led to the establishment of an over-diagnosis epidemic and to an excess of therapeutic interventions, which do not necessarily lead to a longer life expectancy. Some medical controversies, which have called the attention of physicians and even of common people are those related with dislipoproteinemias, pre-diabetes and detection of cancer in asymptomatic persons...
July 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28577673/bridging-income-generation-with-group-integrated-care-for-cardiovascular-risk-reduction-rationale-and-design-of-the-bigpic-study
#10
Rajesh Vedanthan, Jemima H Kamano, Hana Lee, Benjamin Andama, Gerald S Bloomfield, Allison K DeLong, David Edelman, Eric A Finkelstein, Joseph W Hogan, Carol R Horowitz, Simon Manyara, Diana Menya, Violet Naanyu, Sonak D Pastakia, Thomas W Valente, Cleophas C Wanyonyi, Valentin Fuster
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality worldwide, with >80% of CVD deaths occurring in low and middle income countries (LMICs). Diabetes mellitus and pre-diabetes are risk factors for CVD, and CVD is the major cause of morbidity and mortality among individuals with DM. There is a critical period now during which reducing CVD risk among individuals with diabetes and pre-diabetes may have a major impact. Cost-effective, culturally appropriate, and context-specific approaches are required...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28576484/signs-of-subclinical-atherosclerosis-in-asymptomatic-patients-at-increased-risk-of-type-2-diabetes-mellitus
#11
Loretta Zsuzsa Kiss, Zsolt Bagyura, Réka Vadas, Lívia Polgár, Árpád Lux, Eszter Édes, Orsolya Szenczi, Pál Soós, Zsolt Szelid, Dávid Becker, György Jermendy, Béla Merkely
AIMS: We aimed to study carotid intima media thickness (CIMT) in asymptomatic patients with an increased risk of type 2 diabetes mellitus (T2DM) and in a pre-diabetic state. METHODS: Diabetes risk assessment was performed in 2420 participants in a voluntary screening program between 2011 and 2013. The risk of T2DM was estimated by the Findrisc scoring system (FR). A FR≥12 was considered as increased risk. HbA1c% between 5.7 and 6.4% signified a pre-diabetic state...
May 25, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28575729/effects-of-saxagliptin-on-glucose-homeostasis-and-body-composition-of-obese-patients-with-newly-diagnosed-pre-diabetes
#12
Zixuan Wang, Dengcheng Xu, Lanhui Huang, Tiantian Zhang, Junqiao Wang, Qing Chen, Lei Kong, Xinli Zhou
AIMS: To assess the effect of saxagliptin monotherapy on blood glucose and islet β-cell function in obese patients with newly diagnosed pre-diabetes and abnormal fat metabolism. METHODS: A 24-week, randomized controlled trial was conducted involving 25 obese subjects with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) (mean age 45years) to receive lifestyle intervention only (control group) or combined with saxagliptin 2.5mg or 5mg daily (S2...
May 12, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28572882/nonsurgical-periodontal-therapy-improves-glycosylated-hemoglobin-levels-in-pre-diabetic-patients-with-chronic-periodontitis
#13
Rosamma Joseph, Meera Sasikumar, Jerry Mammen, M G Joseraj, Chandni Radhakrishnan
AIM: To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis (CHP). METHODS: Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters (plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin (HbA1c), fasting lipid profile, and fasting blood glucose]...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28571777/postpartum-screening-practices-progression-to-abnormal-glucose-tolerance-and-its-related-risk-factors-in-asian-women-with-a-known-history-of-gestational-diabetes-a-systematic-review-and-meta-analysis
#14
REVIEW
Sedigheh Nouhjah, Hajieh Shahbazian, Neda Amoori, Shayesteh Jahanfar, Nahid Shahbazian, Alireza Jahanshahi, Bahman Cheraghian
AIMS: Rate of postpartum screening and progression to glucose intolerance (diabetes and/or pre-diabetes) in Asian women with prior GDM and risk factors of diversion to abnormal glucose tolerance were reviewed. MATERIALS AND METHODS: We searched Pub Med, Cochrane Library, Web of Science, EMBASE, and Ovid data base. About 1300 studies were screened and 27 articles were selected. Meta-analysis using Comprehensive Meta -Analysis software was conducted. All results were reported at the pooled ORs and 95% CI...
May 24, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28559540/rs9939609-fto-genotype-associations-with-fto-methylation-level-influences-body-mass-and-telomere-length-in-an-australian-rural-population
#15
Y Zhou, D Simmons, D Lai, B D Hambly, C S McLachlan
BACKGROUND: the fat mass- and obesity-associated (FTO) gene influences energy homeostasis in humans. While the obesity-related variant, rs9939609 has been replicated across a number of cohort studies, there remain significant variance and a low modest association. Telomere length is another commonly reported obesity risk factor. We hypothesize understanding the associations between FTO rs9939609 with FTO methylation and telomere length will provide a more accurate assessment of obesity risk...
May 31, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28559285/hepatitis-c-virus-induces-a-pre-diabetic-state-by-directly-impairing-hepatic-glucose-metabolism-in-mice
#16
Hervé Lerat, Mohamed Rabah Imache, Jacqueline Polyte, Aurore Gaudin, Marion Mercey, Flora Donati, Camille Baudesson, Martin R Higgs, Alexandre Picard, Christophe Magnan, Fabienne Foufelle, Jean-Michel Pawlotsky
Virus-related type-2 diabetes is commonly observed in individuals infected with the hepatitis C virus (HCV). However, the underlying molecular mechanisms remain unknown. Our aims were to unravel these mechanisms using FL-N/35 transgenic mice expressing the full HCV-ORF. We observed that these mice displayed glucose intolerance and insulin resistance. We also found that Glut-2 membrane expression was reduced in FL-N/35 mice and that hepatocyte glucose uptake was perturbed, partly accounting for the HCV-induced glucose intolerance in these mice...
May 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28537332/comparison-of-intermittent-fasting-versus-caloric-restriction-in-obese-subjects-a-two-year-follow-up
#17
F B Aksungar, M Sarıkaya, A Coskun, M Serteser, I Unsal
OBJECTIVE: Caloric restriction (CR) is proven to be effective in increasing life span and it is well known that, nutritional habits, sleeping pattern and meal frequency have profound effects on human health. In Ramadan some Muslims fast during the day-light hours for a month, providing us a unique model of intermittent fasting (IF) in humans. In the present study, we have investigated the effects of IF versus CR on the same non-diabetic obese subjects who were followed for two years according to the growth hormone (GH)/Insulin like growth factor (IGF)-1 axis and insulin resistance...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28534880/a-tale-of-two-risks-smoking-diabetes-and-the-subgingival-microbiome
#18
Sukirth M Ganesan, Vinayak Joshi, Megan Fellows, Shareef M Dabdoub, Haikady N Nagaraja, Benjamin O'Donnell, Neeta Rohit Deshpande, Purnima S Kumar
Although smoking and diabetes have been established as the only two risk factors for periodontitis, their individual and synergistic impacts on the periodontal microbiome are not well studied. The present investigation analyzed 2.7 million 16S sequences from 175 non-smoking normoglycemic individuals (controls), smokers, diabetics and diabetic smokers with periodontitis as well as periodontally healthy controls, smokers and diabetics to assess subgingival bacterial biodiversity and co-occurrence patterns. The microbial signatures of periodontally healthy smokers, but not diabetics, were highly aligned with the disease-associated microbiomes of their respective cohorts...
May 23, 2017: ISME Journal
https://www.readbyqxmd.com/read/28532856/implementation-of-a-referral-to-discharge-glycemic-control-initiative-for-reduction-of-surgical-site-infections-in-gynecologic-oncology-patients
#19
Laura Hopkins, Jennifer Brown-Broderick, James Hearn, Janine Malcolm, James Chan, Wendy Hicks-Boucher, Filomena De Sousa, Mark C Walker, Sylvain Gagné
OBJECTIVE(S): To evaluate the frequency of surgical site infections before and after implementation of a comprehensive, multidisciplinary perioperative glycemic control initiative. STUDY METHODS: As part of a CUSP (Comprehensive Unit-based Safety Program) initiative, between January 5 and December 18, 2015, we implemented comprehensive, multidisciplinary glycemic control initiative to reduce SSI rates in patients undergoing major pelvic surgery for a gynecologic malignancy ('Group II')...
May 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28528338/chronic-glibenclamide-treatment-attenuates-walker-256-tumour-growth-in-prediabetic-obese-rats
#20
Claudinéia Conationi da Silva Franco, Carina Previate, Kátia Gama de Barros Machado, Silvano Piovan, Rosiane Aparecida Miranda, Kelly Valério Prates, Veridiana Mota Moreira, Júlio Cezar de Oliveira, Luiz Felipe Barella, Rodrigo Mello Gomes, Flávio Andrade Francisco, Isabela Peixoto Martins, Audrei Pavanello, Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Ananda Malta, Aline Amenencia de Souza, Vander Silva Alves, Sandra da Silva Silveira, Maria Raquel Marçal Natali, Jean Carlos Fernando Besson, Hely de Morais, Helenir Medri de Souza, Juliane Rocha de Sant Anna, Marialba Avezum Alves de Castro Prado, Paulo Cezar de Freitas Mathias
BACKGROUND/AIMS: The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients. However, the mechanisms underlying this observation remain unclear. The aim of the present work was to evaluate whether obese adult rats that were chronically treated with an antidiabetic drug, glibenclamide, exhibit resistance to rodent breast carcinoma growth...
2017: Cellular Physiology and Biochemistry
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