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https://www.readbyqxmd.com/read/27913943/the-cost-effectiveness-of-interventions-targeting-lifestyle-change-for-the-prevention-of-diabetes-in-a-swedish-primary-care-and-community-based-prevention-program
#1
Anne Neumann, Lars Lindholm, Margareta Norberg, Olaf Schoffer, Stefanie J Klug, Fredrik Norström
BACKGROUND: Policymakers need to know the cost-effectiveness of interventions to prevent type 2 diabetes (T2D). The objective of this study was to estimate the cost-effectiveness of a T2D prevention initiative targeting weight reduction, increased physical activity and healthier diet in persons in pre-diabetic states by comparing a hypothetical intervention versus no intervention in a Swedish setting. METHODS: A Markov model was used to study the cost-effectiveness of a T2D prevention program based on lifestyle change versus a control group where no prevention was applied...
December 2, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/27904566/the-characteristics-of-pre-diabetic-patients-associated-with-body-composition-and-cardiovascular-disease-risk-factors-in-the-iranian-population
#2
Zahra Gholi, Motahar Heidari-Beni, Awat Feizi, Bijan Iraj, Gholamreza Askari
BACKGROUND: Different populations have shown various patterns of association between impaired fasting glucose (IFG) and body composition parameters and risk factors of cardiovascular disease (CVD). The current study aimed at investigating the differences between persons with prediabetes and healthy people in terms of CVD risk factors including body composition parameters, blood pressure, and lipid profile in a sample of the Iranian population. MATERIALS AND METHODS: In a case-control setting, a sample containing 386 (193 prediabetic subjects and 193 normal subjects) of the first-degree relatives of diabetic patients aged 35-55 years were investigated...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27902760/socio-economic-inequality-of-chronic-non-communicable-diseases-in-bangladesh
#3
Tuhin Biswas, Md Saimul Islam, Natalie Linton, Lal B Rawal
INTRODUCTION: Chronic non-communicable diseases (NCDs) are a major public health challenge, and undermine social and economic development in much of the developing world, including Bangladesh. Epidemiologic evidence on the socioeconomic status (SES)-related pattern of NCDs remains limited in Bangladesh. This study assessed the relationship between three chronic NCDs and SES among the Bangladeshi population, paying particular attention to the differences between urban and rural areas. MATERIALS AND METHOD: Data from the 2011 Bangladesh Demographic and Health Survey were used for this study...
2016: PloS One
https://www.readbyqxmd.com/read/27902723/should-all-women-with-polycystic-ovary-syndrome-be-screened-for-metabolic-parameters-a-hospital-based-observational-study
#4
Hui Li, Lin Li, Jian Gu, Yu Li, Xiaoli Chen, Dongzi Yang
This hospital-based observational study aims to estimate differences in metabolic abnormalities between different polycystic ovary syndrome (PCOS) phenotypes and their distribution characteristics. The prevalence of metabolic abnormalities among different PCOS phenotypes, including diabetes mellitus (DM), metabolic syndrome (MS), pre-diabetes mellitus (pre-DM), insulin resistance (IR) and dyslipidemia were compared. A total of 2436 women who were ≥18 years old and who were hospitalized in Sun Yat-Sen University affiliated hospital from 1998 to 2015 in GuangZhou, China, were included in this study...
2016: PloS One
https://www.readbyqxmd.com/read/27888740/measuring-ultra-weak-photon-emission-as-a-non-invasive-diagnostic-tool-for-detecting-early-stage-type-2-diabetes-a-step-toward-personalized-medicine
#5
Mengmeng Sun, Eduard Van Wijk, Slavik Koval, Roeland Van Wijk, Min He, Mei Wang, Thomas Hankemeier, Jan van der Greef
The global prevalence of type 2 diabetes is estimated to reach 4.4% by 2030, placing a significant burden on our healthcare system. Therefore, the ability to identify patients in early stages of the disease is essential for both prevention and effective management, and diagnostic methods based on traditional Chinese medicine (TCM) may be suitable for identifying patients with early-stage type 2 diabetes. Here, a panel of three physicians trained in TCM classified 44 pre-diabetic subjects into three syndrome subtypes using TCM-based diagnostics...
November 17, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27878383/hsa_circ_0054633-in-peripheral-blood-can-be-used-as-a-diagnostic-biomarker-of-pre-diabetes-and-type-2-diabetes-mellitus
#6
Zhenzhou Zhao, Xuejie Li, Dongdong Jian, Peiyuan Hao, Lixin Rao, Muwei Li
AIMS: The purpose of the current study was to investigate the characteristic expression of circular RNAs (circRNAs) in the peripheral blood of type 2 diabetes mellitus (T2DM) patients and their potential as diagnostic biomarkers for pre-diabetes and T2DM. METHODS: CircRNAs in the peripheral blood from six healthy individuals and six T2DM patients were collected for microarray analysis, and an independent cohort study consisting of 20 normal cases, 20 pre-diabetes patients and 20 T2DM patients was conducted to verify the five chosen circRNAs...
November 23, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27875248/vildagliptin-and-caloric-restriction-for-cardioprotection-in-pre-diabetic-rats
#7
Pongpan Tanajak, Hiranya Pintana, Natthaphat Siri-Angkul, Juthamas Khamseekaew, Nattayaporn Apaijai, Siriporn C Chattipakorn, Nipon Chattipakorn
Long-term high-fat diet (HFD) consumption causes cardiac dysfunction. Although calorie restriction (CR) has been shown to be useful in obesity, we hypothesized that combined CR with dipeptidyl peptidase-4 (DPP-4) inhibitor provides greater efficacy than monotherapy in attenuating cardiac dysfunction and metabolic impairment in HFD-induced obese-insulin resistant rats. Thirty male Wistar rats were divided into 2 groups to be fed on either a normal diet (ND, n = 6) or a HFD (n = 24) for 12 weeks. Then, HFD rats were divided into 4 subgroups (n = 6/subgroup) to receive just the vehicle, CR diet (60% of mean energy intake and changed to ND), vildagliptin (3 mg/kg/day) or combined CR and vildagliptin for 4 weeks...
February 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27865163/evaluation-of-patients-with-type-2-diabetes-mellitus-receiving-treatment-during-the-pre-diabetes-period-is-early-treatment-associated-with-improved-outcomes
#8
Paresh Chaudhari, Carlos Vallarino, Ernest H Law, Raafat Seifeldin
AIM: This study evaluates the association of pretreatment with oral antidiabetics (OADs) on clinical outcomes and health resource utilization among commercially insured type II diabetes mellitus (T2DM) patients in the United States. METHODS: Using administrative data (Truven MarketScan® Research Databases), patients diagnosed with T2DM between 2007 and 2014 with ⩾6months continuous enrolment pre- and post-diagnosis were evaluated. Pretreatment was defined as OAD use at least 3months prior to T2DM diagnosis...
November 3, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27859570/diabetes-incidence-and-prevalence-in-hong-kong-china-during-2006-2014
#9
J Quan, T K Li, H Pang, C H Choi, S C Siu, S Y Tang, N M Wat, J Woo, J M Johnston, G M Leung
AIMS: To estimate recent secular changes in the incidence and prevalence of diabetes and pre-diabetes among Hong Kong Chinese adults, and thus show possible future trends for developing mainland China. METHODS: Based on a complete census of the public sector health records of 6.4 million people from 2006 to 2014, diabetes cases were ascertained using different methods including the World Health Organization (WHO) 2011 guidelines (HbA1c , fasting plasma glucose and glucose tolerance test), American Diabetes Association (ADA) 2015 guidelines (plus random plasma glucose), and additionally recorded diagnosis codes and medication dispensation...
November 12, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27843552/remission-of-pre-diabetes-to-normal-glucose-tolerance-in-obese-adults-with-high-protein-versus-high-carbohydrate-diet-randomized-control-trial
#10
Frankie B Stentz, Amy Brewer, Jim Wan, Channing Garber, Blake Daniels, Chris Sands, Abbas E Kitabchi
OBJECTIVE: Remission of pre-diabetes to normal is an important health concern which has had little success in the past. This study objective was to determine the effect on remission of pre-diabetes with a high protein (HP) versus high carbohydrate (HC) diet and effects on metabolic parameters, lean and fat body mass in prediabetic, obese subjects after 6 months of dietary intervention. RESEARCH DESIGN AND METHODS: We recruited and randomized 24 pre-diabetes women and men to either a HP (30% protein, 30% fat, 40% carbohydrate; n=12) or HC (15% protein, 30% fat, 55% carbohydrate; n=12) diet feeding study for 6 months in this randomized controlled trial...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27843495/adipose-tissue-dysfunction-increases-fatty-liver-association-with-pre-diabetes-and-newly-diagnosed-type-2-diabetes-mellitus
#11
Esteban Jorge-Galarza, Aida Medina-Urrutia, Rosalinda Posadas-Sánchez, Carlos Posadas-Romero, Guillermo Cardoso-Saldaña, Gilberto Vargas-Alarcón, Nacú Caracas-Portilla, Carmen González-Salazar, Margarita Torres-Tamayo, Juan Gabriel Juárez-Rojas
BACKGROUND: To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D). METHODS: In 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma glucose, <5.6, 5.6-6.9 and ≥7 mmol/l, were used to defined normoglycemic (NG), IFG or nT2D, respectively. Elevated free fatty acids, low serum adiponectin levels and adipose tissue insulin resistance (Adipo-IR), were used as markers of adipose tissue dysfunction...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27837448/consensus-on-the-statin-of-choice-in-patients-with-impaired-glucose-metabolism-results-of-the-diana-study
#12
Jesús Millán Núñez-Cortés, Aleix Cases Amenós, Juan Francisco Ascaso Gimilio, Vivencio Barrios Alonso, Vicente Pascual Fuster, Juan Carles Pedro-Botet Montoya, Xavier Pintó Sala, Adalberto Serrano Cumplido
INTRODUCTION AND OBJECTIVES: Despite the recognized clinical benefit of statins on cardiovascular prevention, providing correct management of hypercholesterolaemia, possible adverse effects of their use cannot be disregarded. Previously published data shows that there is a risk of developing diabetes mellitus or experiencing changes in glucose metabolism in statin-treated patients. The possible determining factors are the drug characteristics (potency, dose), patient characteristics (kidney function, age, cardiovascular risk and polypharmacy because of multiple disorders) and the pre-diabetic state...
November 11, 2016: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/27834060/morning-spot-urine-glucose-to-creatinine-ratios-predict-overnight-urinary-glucose-excretion-in-patients-with-type-2-diabetes
#13
So Ra Kim, Yong Ho Lee, Sang Guk Lee, Sun Hee Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Jeong Ho Kim, Byung Wan Lee
BACKGROUND: With the advent of sodium glucose co-transporter 2 inhibitors to control glucose and treat diabetes, laboratory data aided by either timed or spot glucose levels in the urine could be used as an alternative marker of drug response. The aim of this study was to assess the agreement between overnight urinary glucose excretion (UGE) and morning spot urinary glucose-to-creatinine ratio (UGCR). METHODS: In this prospective cross-sectional study, we enrolled a total of 215 participants with either normal glucose tolerance (NGT), pre-diabetes, or type 2 diabetes mellitus (T2DM)...
January 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/27819150/systematic-literature-review-of-the-health-economic-implications-of-early-detection-by-screening-populations-at-risk-for-type-2-diabetes
#14
Thomas R Einarson, Basil G Bereza, Annabel Acs, Rasmus Jensen
BACKGROUND: Undetected/uncontrolled diabetes is associated with substantial morbidity and mortality and consequent costs. Early detection through screening identifies patients at risk, allowing for earlier treatment initiation. OBJECTIVES: To determine the economic impact of screening for type 2 diabetes (T2DM). DATA SOURCES: We systematically reviewed health economic analyses of screening programs for T2DM/pre-diabetes. STUDY ELIGIBILITY CRITERIA: Published between 2000 and 2015 in any language...
November 16, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27818934/glucose-6-phosphate-dehydrogenase-contributes-to-the-regulation-of-glucose-uptake-in-skeletal-muscle
#15
Robert S Lee-Young, Nolan J Hoffman, Kate T Murphy, Darren C Henstridge, Dorit Samocha-Bonet, Andrew L Siebel, Peter Iliades, Borivoj Zivanovic, Yet H Hong, Timothy D Colgan, Michael J Kraakman, Clinton R Bruce, Paul Gregorevic, Glenn K McConell, Gordon S Lynch, Grant R Drummond, Bronwyn A Kingwell, Jerry R Greenfield, Mark A Febbraio
OBJECTIVE: The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved. Here, we have examined the role of glucose-6-phosphate dehydrogenase (G6PDH) activity in the pathogenesis of insulin resistance in skeletal muscle. METHODS: Multiple mouse disease states exhibiting insulin resistance and glucose intolerance, as well as obese humans defined as insulin-sensitive, insulin-resistant, or pre-diabetic, were examined...
November 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27818377/diabetes-mellitus-and-the-incidence-of-hearing-loss-a-cohort-study
#16
Min-Beom Kim, Yiyi Zhang, Yoosoo Chang, Seungho Ryu, Yuni Choi, Min-Jung Kwon, Il Joon Moon, Jennifer A Deal, Frank R Lin, Eliseo Guallar, Eun Chul Chung, Sung Hwa Hong, Jae Ho Ban, Hocheol Shin, Juhee Cho
BACKGROUND: To evaluate the association between diabetes mellitus (DM) and the development of incident hearing loss. METHODS: Prospective cohort study was performed in 253 301 adults with normal hearing tests who participated in a regular health-screening exam between 2002 and 2014. The main exposure was the presence of DM at baseline, defined as a fasting serum glucose ≥ 126 mg/dL, a self-reported history of DM or current use of anti-diabetic medications. Pre-diabetes was defined as a fasting glucose 100-125 mg/dL and no history of DM or anti-diabetic medication use...
November 6, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27798659/double-trouble-prevalence-and-factors-associated-with-tuberculosis-and-diabetes-comorbidity-in-bangladesh
#17
Malabika Sarker, Mrittika Barua, Fiona Guerra, Avijit Saha, Afzal Aftab, A H M Mahbub Latif, Shayla Islam, Akramul Islam
BACKGROUND: Diabetes among tuberculosis patients increases the risk of tuberculosis treatment failure, death, and development of multidrug-resistant tuberculosis. Yet, there is no data is available in Bangladesh on the prevalence of diabetes among tuberculosis patients. The objective of the current study was to estimate prevalence and identify factors associated with tuberculosis-diabetes co-morbidity among TB patients enrolled in the Directly Observed Treatment, Short course program...
2016: PloS One
https://www.readbyqxmd.com/read/27795816/update-on-pre-diabetes-focus-on-diagnostic-criteria-and-cardiovascular-risk
#18
REVIEW
Antonino Di Pino, Francesca Urbano, Salvatore Piro, Francesco Purrello, Agata Maria Rabuazzo
Pre-diabetes, which is typically defined as blood glucose concentrations higher than normal but lower than the diabetes threshold, is a high-risk state for diabetes and cardiovascular disease development. As such, it represents three groups of individuals: Those with impaired fasting glucose (IFG), those with impaired glucose tolerance (IGT) and those with a glycated haemoglobin (HbA1c) between 39-46 mmol/mol. Several clinical trials have shown the important role of IFG, IGT and HbA1c-pre-diabetes as predictive tools for the risk of developing type 2 diabetes...
October 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27792861/pre-diabetes-and-serum-sex-steroid-hormones-among-us-men
#19
R Arthur, S Rohrmann, H Møller, E Selvin, A S Dobs, N Kanarek, W Nelson, E A Platz, M Van Hemelrijck
Several studies demonstrate a link between diabetes and sex steroid hormones, but the link with pre-diabetes remains elusive. In this study, we hypothesize that pre-diabetes, which is characterised by having impaired fasting glucose and/or impaired glucose tolerance and/or impaired HbA1C, may influence circulating sex steroid hormone concentrations in men. Thus, we investigated whether serum sex steroid hormone concentrations differ between men with and without pre-diabetes. We analyzed data for 1139 men who were aged 20+ years when they participated in the Third National Health and Nutrition Examination Survey...
October 28, 2016: Andrology
https://www.readbyqxmd.com/read/27790148/in-vivo-evaluation-of-two-thiazolidin-4-one-derivatives-in-high-sucrose-diet-fed-pre-diabetic-mice-and-their-modulatory-effect-on-ampk-akt-and-p38-map-kinase-in-l6-cells
#20
Jayesh Mudgal, Priya Shetty, Neetinkumar D Reddy, H S Akhila, Karthik Gourishetti, Geetha Mathew, Pawan G Nayak, Nitesh Kumar, Anoop Kishore, Nampurath G Kutty, Krishnadas Nandakumar, Rekha R Shenoy, Chamallamudi M Rao, Alex Joseph
We had previously demonstrated the anti-diabetic potential and pancreatic protection of two thiazolidin-4-one derivatives containing nicotinamide moiety (NAT-1 and NAT-2) in STZ-induced diabetic mice. However, due to the limitations of the STZ model, we decided to undertake a detailed evaluation of anti-diabetic potential of the molecules on a high sucrose diet (HSD) fed diabetic mouse model. Further, in vitro mechanistic studies on the phosphorylation of AMPK, Akt and p38 MAP kinase in L6 myotubes and anti-inflammatory studies in RAW264...
2016: Frontiers in Pharmacology
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