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https://www.readbyqxmd.com/read/28334605/new-horizons-in-diabetic-neuropathy-mechanisms-bioenergetics-and-pain
#1
REVIEW
Eva L Feldman, Klaus-Armin Nave, Troels S Jensen, David L H Bennett
Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic complications create a substantial burden on both the afflicted patients and society as a whole. Given the enormity of the problem and the lack of effective therapies, there is a pressing need to understand the mechanisms underlying diabetic neuropathy (DN). In this review, we present the structural components of the peripheral nervous system that underlie its susceptibility to metabolic insults and then discuss the pathways that contribute to peripheral nerve injury in DN...
March 22, 2017: Neuron
https://www.readbyqxmd.com/read/28323968/impaired-glycine-mia-in-type-2-diabetes-and-potential-mechanisms-contributing-to-glucose-homeostasis
#2
Richard Yan-Do, Patrick E MacDonald
The onset and/or progression of type 2 diabetes (T2D) can be prevented if intervention is early enough. As such, much effort has been placed on the search for indicators predictive of pre-diabetes and disease onset or progression. An increasing body of evidence suggests that changes in plasma glycine may be one such biomarker. Circulating glycine levels are consistently low in patients with T2D. Levels of this non-essential amino acid correlate negatively with obesity and insulin resistance. Plasma glycine correlates positively with glucose disposal, and rises with interventions such as exercise and bariatric surgery that improve glucose homeostasis...
March 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323952/randomized-controlled-trial-of-a-mufa-or-fiber-rich-diet-on-hepatic-fat-in-pre-diabetes
#3
Isabel Errazuriz, Simmi Dube, Michael Slama, Roberto Visentin, Sunita Nayar, Helen O'Connor, Claudio Cobelli, Swapan Kumar Das, Ananda Basu, Walter Karl Kremers, John Port, Rita Basu
Context: Increased prevalence of type 2 diabetes mellitus and prediabetes worldwide has been attributed, at least in part, to a modern lifestyle, in particular, to an unhealthy diet. Objective: To evaluate whether 12 weeks of high MUFA or fiber-rich weight maintenance diet lowers hepatic fat and improves glucose tolerance in people with prediabetes. Design: Subjects underwent a [6, 6-2H2] labeled 75 g oral glucose tolerance test to estimate hepatic insulin sensitivity (Siliver) along with measurement of liver fat fraction (LFF) using magnetic resonance spectroscopy before and after intervention...
March 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28316794/periodontitis-as-a-possible-early-sign-of-diabetes-mellitus
#4
Wijnand J Teeuw, Madeline X F Kosho, Dennis C W Poland, Victor E A Gerdes, Bruno G Loos
OBJECTIVE: The early diagnosis of (pre)diabetes mellitus is essential for the prevention of diabetes complications. It has been suggested that gum disease (periodontitis) might be an early complication of diabetes and may be a useful risk indicator for diabetes screening. Therefore, a dental office could be a good location for screening for (pre)diabetes in patients with periodontitis using a validated glycated hemoglobin (HbA1c) dry spot analysis. RESEARCH DESIGN AND METHODS: A total of 313 individuals from a university dental clinic participated...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28304331/inverse-association-of-plasma-chromium-levels-with-newly-diagnosed-type-2-diabetes-a-case-control-study
#5
Sijing Chen, Xiaoling Jin, Zhilei Shan, Shuzhen Li, Jiawei Yin, Taoping Sun, Cheng Luo, Wei Yang, Ping Yao, Kaifeng Yu, Yan Zhang, Qian Cheng, Jinquan Cheng, Wei Bao, Liegang Liu
Chromium has long been known as an enhancer of insulin action. However, the role of chromium in the development of type 2 diabetes mellitus (T2DM) in humans remains controversial. The current study aimed to examine the associations of plasma chromium levels with T2DM and pre-diabetes mellitus (pre-DM). We conducted a case-control study involving 1471 patients with newly diagnosed T2DM, 682 individuals with newly diagnosed pre-DM, and 2290 individuals with normal glucose tolerance in a Chinese population from 2009 to 2014...
March 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28297698/magnesium-replacement-improves-the-metabolic-profile-in-obese-and-pre-diabetic-patients-with-mild-to-moderate-chronic-kidney-disease-a-3-month-randomised-double-blind-placebo-controlled-study
#6
Omer Toprak, Huseyin Kurt, Yasin Sarı, Cihat Şarkış, Halil Us, Ali Kırık
BACKGROUND/AIMS: Magnesium is an essential mineral for many metabolic functions. There is very little information on the effect of magnesium supplementation on metabolic profiles of chronic kidney disease (CKD) patients. The aim of this study was to assess the influence of magnesium supplementation on metabolic profiles of pre-diabetic, obese and mild-to-moderate CKD patients with hypomagnesemia. METHODS: A total of 128 hypomagnesemic, pre-diabetic and obese patients with an estimated glomerular filtration rate between 90 and 30 ml/min/1...
March 13, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28294635/maintenance-of-weight-loss-or-stability-in-subjects-with-obesity-a-retrospective-longitudinal-analysis-of-a-real-world-population
#7
Maral DerSarkissian, Rachel H Bhak, Joanna Huang, Sarah Buchs, Francis Vekeman, B Gabriel Smolarz, Jason Brett, Rahul Ganguly, Mei Sheng Duh
OBJECTIVES: Characterize patterns of weight change among subjects with obesity. METHODS: A retrospective observational longitudinal study of subjects with obesity was conducted using the General Electric Centricity electronic medical record database. Subjects who were ≥18 years old with BMI ≥30 kg/m(2) (first defining index BMI), had no medical conditions associated with unintentional weight loss, and had ≥4 BMI measurements/year for ≥2.5 years were included and categorized into groups (stable weight: within <5% of index BMI; modest weight loss: ≥5 to <10% of index BMI lost; moderate weight loss: ≥10 to <15% of index BMI lost; and high weight loss: ≥15% of index BMI lost) based on weight change during six months following index...
March 15, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28285650/plasma-hdl-cholesterol-and-triglycerides-but-not-ldl-cholesterol-are-associated-with-insulin-secretion-in-non-diabetic-subjects
#8
Andrea Natali, Simona Baldi, Fabrice Bonnet, John Petrie, Silvia Trifirò, Domenico Tricò, Andrea Mari
OBJECTIVE: Experimental data support the notion that lipoproteins might directly affect beta cell function, however clinical data are sparse and inconsistent. We aimed at verifying whether, independently of major confounders, serum lipids are associated with alterations in insulin secretion or clearance non-diabetic subjects. METHODS: Cross sectional and observational prospective (3.5yrs), multicentre study in which 1016 non-diabetic volunteers aged 30-60yrs. and with a wide range of BMI (20...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28276790/new-onset-diabetes-mellitus-induced-by-statins-current-evidence
#9
Steven G Chrysant
The hydroxyl-methyl-glutaryl-coenzyme-A (HMG-CoA) reductase inhibitors of statin action are very effective and safe drugs, and they are widely used for the treatment of hyperlipidemia and the prevention of primary and secondary cardiovascular diseases (CVDs). However, recent meta-analyses of previous studies done with statins have shown that these drugs could induce new onset diabetes mellitus (NODM), especially in subjects prone to diabetes: obese, females, older age, Asian descent, and those with pre-diabetes or the metabolic syndrome...
February 24, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28273202/lifestyle-intervention-using-the-psychoeducational-approach-is-associated-with-greater-cardiometabolic-benefits-and-retention-of-individuals-with-worse-health-status
#10
Adriana Cezaretto, Camila Risso de Barros, Bianca de Almeida-Pititto, Antonela Siqueira-Catania, Milena Monfort-Pires, Luciana Gavilan Dias Folchetti, Sandra Roberta Gouvea Ferreira
Objective: This study aimed to compare the effects of two lifestyle intervention programs for type 2 diabetes mellitus (T2DM) prevention - traditional or interdisciplinary psychoeducation-based intervention - in daily habits and cardiometabolic risk factors and investigate the role of the psychoeducational approach for the retention of individuals in the program. Subjects and methods: Between 2008 and 2010, in a public health service, 183 pre-diabetic individuals were allocated to two 18-month interventions involving diet and physical activity...
January 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28258520/novel-inflammatory-markers-for-incident-pre-diabetes-and-type-2-diabetes-the-rotterdam-study
#11
Adela Brahimaj, Symen Ligthart, Mohsen Ghanbari, Mohammad Arfan Ikram, Albert Hofman, Oscar H Franco, Maryam Kavousi, Abbas Dehghan
The immune response involved in each phase of type 2 diabetes (T2D) development might be different. We aimed to identify novel inflammatory markers that predict progression from normoglycemia to pre-diabetes, incident T2D and insulin therapy. We used plasma levels of 26 inflammatory markers in 971 subjects from the Rotterdam Study. Among them 17 are novel and 9 previously studied. Cox regression models were built to perform survival analysis. MAIN OUTCOME MEASURES: During a follow-up of up to 14...
March 3, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28258467/diabetes-in-immigrant-tibetan-muslims-in-kashmir-north-india
#12
Mirza Shohiab Ur Riyaz, Majid Khalil Rather, Parvaiz A Koul
Tibetan Muslims have migrated from Lhasa (3000 m altitude) to Srinagar, India (altitude 1500 m) about 55 years back. We set out to study the prevalence of diabetes and prediabetes among this immigrant population. All consenting adults aged ≥18 years were questioned about a previous history of diabetes or any other medical history. Anthropometric data were recorded. Fasting blood glucose was measured in duplicate by Accu-check glucometer and HbA1C levels were measured. Of the 281 participants, 26 (9.25%) had diabetes whereas 46 (16...
March 3, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28249170/plasma-dihydroceramides-are-diabetes-susceptibility-biomarker-candidates-in-mice-and-humans
#13
Leonore Wigger, Céline Cruciani-Guglielmacci, Anthony Nicolas, Jessica Denom, Neïké Fernandez, Frédéric Fumeron, Pedro Marques-Vidal, Alain Ktorza, Werner Kramer, Anke Schulte, Hervé Le Stunff, Robin Liechti, Ioannis Xenarios, Peter Vollenweider, Gérard Waeber, Ingo Uphues, Ronan Roussel, Christophe Magnan, Mark Ibberson, Bernard Thorens
Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma lipid species whose concentrations correlate with various parameters of glucose homeostasis and susceptibility to type 2 diabetes (T2D). Shotgun lipidomic analysis of the plasma of mice from different genetic backgrounds, which develop a pre-diabetic state at different rates when metabolically stressed, led to the identification of a group of sphingolipids correlated with glucose tolerance and insulin secretion...
February 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/28238331/prognostic-value-of-blood-glucose-in-emergency-room-and-glycosylated-hemoglobin-in-patients-who-have-suffered-an-acute-cerebro-vascular-event
#14
Ander Ernaga Lorea, María Cecilia Hernández Morhain, María Dolores Ollero García-Agulló, Juan Pablo Martínez de Esteban, Ana Iriarte Beroiz, Jaime Gállego Culleré
BACKGROUND AND OBJECTIVE: Stress hyperglycemia has been associated with a worse prognosis in patients hospitalized in critical care units. The aim of this study is to evaluate the impact of blood glucose and glycosylated hemoglobin (HbA1c) levels on the mortality of patients suffering a acute cerebro-vascular event, and to determine if this relationship depends on the presence of diabetes. MATERIAL AND METHODS: A retrospective analysis of 255 patients admitted to the ER for stroke was performed...
February 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28218739/suppression-of-islet-homeostasis-protein-thwarts-diabetes-mellitus-progression
#15
Seh-Hoon Oh, Marda L Jorgensen, Clive H Wasserfall, Altin Gjymishka, Bryon E Petersen
During progression to type 1 diabetes, insulin-producing β-cells are lost through an autoimmune attack resulting in unrestrained glucagon expression and secretion, activation of glycogenolysis, and escalating hyperglycemia. We recently identified a protein, designated islet homeostasis protein (IHoP), which specifically co-localizes within glucagon-positive α-cells and is overexpressed in the islets of both post-onset non-obese diabetic (NOD) mice and type 1 diabetes patients. Here we report that in the αTC1...
February 20, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28213010/the-pathogenesis-and-pathophysiology-of-gestational-diabetes-mellitus-deductions-from-a-three-part-longitudinal-metabolomics-study-in-china
#16
REVIEW
Kai P Law, Hua Zhang
Gestational diabetes mellitus (GDM) is a form of diabetes that is first recognised during pregnancy, with no evidence of pre-existing type 1 or type 2 diabetes. The prevalence of GDM has been rising steadily over the past few decades, coinciding with the ongoing epidemic of obesity and type 2 diabetes. Although GDM normally disappears after delivery, women who have been previously diagnosed with GDM are at a greater risk of developing gestational diabetes in subsequent pregnancies, and type 2 diabetes later in life...
February 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28212346/the-relationship-between-physical-activity-and-plasma-glucose-level-amongst-ellisras-rural-young-adult-males-and-females-ellisras-longitudinal-study
#17
Moloko Matshipi, Kotsedi Daniel Monyeki, Han Kemper
Unhealthy lifestyle characteristics such as low physical activity (PA) and high plasma glucose levels (PGLs) may lead to the development of type 2 diabetes mellitus in adulthood. The aim of this study was to investigate (i) the level of physical activity; (ii) the prevalence of pre-diabetes and (iii) the relationship between PA and plasma glucose level in a rural Ellisras adult population aged 18 to 28 years. A total of 713 young adults (349 males and 364 females) who took part in the Ellisras Longitudinal Study participated in the study...
February 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28198145/secular-and-race-ethnic-trends-in-glycemic-outcomes-by-bmi-in-us-adults-the-role-of-waist-circumference
#18
Sandra S Albrecht, Elizabeth Mayer-Davis, Barry M Popkin
BACKGROUND: For the same BMI level, waist circumference (WC) is higher in more recent years. How this impacts diabetes and pre-diabetes prevalence in the US and for different race/ethnic groups is unknown. We examined prevalence differences diabetes and pre-diabetes by BMI over time, investigated whether estimates were attenuated after adjusting for WC, and evaluated implications of these patterns on race/ethnic disparities in glycemic outcomes. METHODS: Data came from 12,614 participants aged 20-74 years from the National Health and Nutrition Examination Surveys (1988-1994; 2007-2012)...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28192103/endoscopic-bariatric-and-metabolic-therapies-new-and-emerging-technologies
#19
Shelby Sullivan, Steven A Edmundowicz, Christopher C Thompson
Endoscopic Bariatric and Metabolic Therapies (EBMT) are a new addition to the treatment arsenal for obesity. These include devices which are placed or removed via flexible endoscopy, and procedures which utilize instruments that require flexible endoscopy for the indications of weight loss or treatment of glucose intolerance (from pre-diabetes to diabetes). The EBMTs are generally divided into gastric and small bowel categories, and although individual EBMTs may have unique mechanisms of action, similar themes in proposed mechanism of action are seen in the gastric and small bowel EBMTs respectively...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28178934/the-prevalence-and-incidence-of-frailty-in-pre-diabetic-and-diabetic-community-dwelling-older-population-results-from-beijing-longitudinal-study-of-aging-ii-blsa-ii
#20
Jagadish Kumar Chhetri, Zheng Zheng, Xitong Xu, Cuihong Ma, Piu Chan
BACKGROUND: Various factors including cardio-metabolic disorders are found to be correlated with frailty. With the increase in age, older adults are likely to have elevated blood glucose level. In this study we intend to investigate the prevalence and incidence of frailty in the pre-diabetic and diabetic community dwelling elderly population and the associated risk factors. METHODS: At baseline total of 10,039 subjects with a mean age of 70.51 (±7.82) were included...
February 8, 2017: BMC Geriatrics
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