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https://www.readbyqxmd.com/read/28648383/optical-coherence-tomography-angiography-in-dry-age-related-macular-degeneration
#1
REVIEW
Maria Vittoria Cicinelli, Alessandro Rabiolo, Riccardo Sacconi, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
Optical coherence tomography angiography (OCT-A) is a new imaging modality that provides non-invasive characterization and quantification of the microvasculature in different retinal conditions. The purpose of this paper is to give an updated review of the features of dry age-related macular degeneration investigated by means of new generation OCT-A. We searched PubMed and Medline using the terms "optical coherence tomography angiography" associated with "age-related macular degeneration", "drusen", "reticular pseudodrusen," and "geographic atrophy" and reviewed publications up to January, 2017...
June 22, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28632844/complement-mediated-regulation-of-apolipoprotein-e-in-cultured-human-rpe-cells
#2
Ping Yang, Nikolai P Skiba, Grace M Tewkesbury, Victoria M Treboschi, Peter Baciu, Glenn J Jaffe
PURPOSE: Complement activation is implicated in the pathogenesis of age-related macular degeneration (AMD). Apolipoprotein E (ApoE) and complement activation products such as membrane attack complex (MAC) are present in eyes of individuals with AMD. Herein, we investigated the effect of complement activation on induction of ApoE accumulation in human retinal pigment epithelial (RPE) cells. METHODS: Cultured human RPE cells were primed with a complement-fixing antibody followed by treatment with C1q-depleted (C1q-Dep) human serum to elicit alternative pathway complement activation...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28607377/amyloid-%C3%AE-peptides-overexpression-in-retinal-pigment-epithelial-cells-via-aav-mediated-gene-transfer-mimics-amd-like-pathology-in-mice
#3
Tuhina Prasad, Ping Zhu, Amrisha Verma, Paramita Chakrabarty, Awilda M Rosario, Todd E Golde, Qiuhong Li
Age-related macular degeneration (AMD) is a progressive retinal neurodegenerative disorder characterized by extracellular deposits known as drusen. A major constituent of drusen deposits are Alzheimer disease-associated amyloid β (Aβ) peptides. To understand the etiology of Aβ proteostasis in AMD, we delivered recombinant adeno-associated virus (AAV) encoding Aβ42 and Aβ40 peptides fused to BRI2 protein by intraocular injection in C57BL/6J mice. Endogenous protease cleavage of such constructs leads to production of secreted Aβ42 and Aβ40 respectively...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28605813/overexpression-of-angiotensin-converting-enzyme-2-ameliorates-amyloid-%C3%AE-induced-inflammatory-response-in-human-primary-retinal-pigment-epithelium
#4
Xinyu Fu, Ru Lin, Yiguo Qiu, Peng Yu, Bo Lei
Purpose: Amyloid-β (Aβ) is a major constituent of drusen, which is a hallmark of early AMD. The purpose of this study was to investigate whether enhancement of ACE2, an important component of the protective angiotensin-converting enzyme 2 (ACE2)/Ang-(1-7)/Mas axis of the renin angiotensin system (RAS), ameliorates Aβ-induced inflammatory response in human RPE cells. Methods: Annexin-V FITC/propidium iodide assay for detecting apoptosis rate was used to determine the optimum concentration and incubation time of Aβ1-42...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28599331/-the-aging-retina-in-the-context-of-cerebral-neurodegenerative-diseases
#5
Michael R R Böhm, Solon Thanos
Background Neurodegenerative diseases (ND) consist of divers affections of the central nervous system related to etiology, localization, and of course of the disease. Alzheimer's disease (AD) and related dementias are best investigated together with socioeconomic conditions and play an important role in its high prevalence. This work will present ND diseases in the context of analogous retinal degeneration mechanisms and ophthalmological diseases. Methods Based on epidemiological data, the current neurological bibliography of ND has been considered...
June 9, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28591287/large-colloid-drusen-analyzed-with-structural-en-face-optical-coherence-tomography
#6
Nathália Corbelli Roberti, João Rafael de Oliveira Dias, Eduardo Amorim Novais, Caio Saito Regatieri, Rubens Belfort
Drusen are extracellular deposits between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch's membrane. Large colloid drusen (LCD) are located below the RPE and are characterized by multiple, large, dome-shaped RPE detachments, with marked attenuation of the ellipsoid zone overlaying the drusen. This report presents the structural en face optical coherence tomography (OCT) findings of LCD and relates them to findings from fluorescein and indocyanine green angiography...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28583322/ocular-findings-in-patients-with-cholestatic-disorders-of-infancy-a-single-centre-experience
#7
Hanaa El-Karaksy, Dalia Hamed, Hanan Fouad, Engy Mogahed, Heba Helmy, Fotouh Hasanain
BACKGROUND AND STUDY AIMS: Neonatal cholestasis can be associated with ocular findings that might aid in its diagnosis, e.g., Alagille syndrome (AGS) and Niemann Pick disease (NPD). We aimed to investigate the frequency of ocular manifestations in infants with cholestasis. PATIENTS AND METHODS: This cross-sectional study included cholestatic infants presenting to the Paediatric Hepatology Unit, Cairo University Paediatric Hospital, Cairo, Egypt. All infants underwent examination of lid, ocular motility, anterior and posterior segments and measurement of intraocular pressure, cycloplegic refraction, ocular ultrasonography and vision...
June 2, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28558370/genetic-polymorphisms-and-the-phenotypic-characterization-of-individuals-with-early-age-related-macular-degeneration
#8
Michael Oeverhaus, Verena Meyer Zu Westrup, Martha Dietzel, Hans-Werner Hense, Daniel Pauleikhoff
PURPOSE: While the importance of risk polymorphisms for the pathogenesis of age-related macular degeneration (AMD) is well established, their impact on morphological and functional phenotypes is largely unclear. We aimed to characterize individual phenotypes in patients who were either homozygous for a risk allele in the CFH gene, ARMS2 gene, or both as compared to non-carriers. METHODS: Patients with early AMD (n = 85) were assessed during a follow-up examination of a prospective study (MARS) with multimodal diagnostics including SD-OCT and microperimetry...
May 31, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28557901/improving-the-age-related-macular-degeneration-construct-a-new-classification-system
#9
Richard F Spaide
Previous models of disease in age-related macular degeneration (AMD) were incomplete in that they did not encompass subretinal drusenoid deposits (pseudodrusen), subtypes of neovascularization, and polypoidal choroidal vasculopathy. In addition, Type 3 neovascularization starts in the retina and may not necessarily involve the choroid. As such, the term choroidal neovascularization is not appropriate for these eyes. The new aspects in the AMD construct are to include specific lipoprotein extracellular accumulations, namely drusen and subretinal drusenoid deposits, as early AMD...
May 26, 2017: Retina
https://www.readbyqxmd.com/read/28534244/proposal-of-a-simple-optical-coherence-tomography-based-scoring-system-for-progression-of-age-related-macular-degeneration
#10
Jianqin Lei, Siva Balasubramanian, Nizar Saleh Abdelfattah, Muneeswar G Nittala, SriniVas R Sadda
PURPOSE: To develop a simple, clinically practical, optical coherence tomography (OCT)-based scoring system for early age-related macular degeneration (AMD) to prognosticate risk for progression to late AMD. METHODS: We retrospectively reviewed OCT images (512 × 128 macular cube, Cirrus) from 138 patients diagnosed of early AMD in at least one eye and follow-up of at least 12 months. For patients with early AMD in both eyes, only the right eye was chosen as the study eye for longitudinal assessment...
May 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28520583/focal-capillary-dropout-associated-with-optic-disc-drusen-using-optical-coherence-tomographic-angiography
#11
Eric D Gaier, Joseph F Rizzo, John B Miller, Dean M Cestari
Optic disc drusen may be a cause of visual field defects and visual loss. The mechanism by which this occurs is unclear. We report a patient who developed decreased vision in the right eye and was found to have a heavy burden of superficial optic disc drusen. Optical coherence tomography (OCT) confirmed focal retinal nerve fiber layer thinning that corresponded with the distribution of drusen. OCT angiography, with superficial laminar segmentation, showed focal capillary attenuation overlying the most prominent drusen...
May 4, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28511857/posterior-microphthalmos-retinitis-pigmentosa-and-optic-disc-drusen-with-white-dots-a-case-report
#12
P Plaza, O Iturralde, C Abascal
OBJECTIVE: To present the case of a patient with a posterior microphthalmos-optic disc drusen-retinitis pigmentosa syndrome associated, for the first time, with white dots in the posterior pole. METHODOLOGY: The posterior microphthalmos, retinitis pigmentosa and optic disc drusen syndrome was described for the first time in literature in 1991. Later, it was associated with a pattern of foveal thickening and/or foveoschisis. Different forms of mutations on chromosomes 11 and 14 have been identified as being responsible for the appearance of this syndrome, but the inheritance pattern is unknown...
May 13, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28511025/co-inheritance-of-the-membrane-frizzled-related-protein-ocular-phenotype-and-glycogen-storage-disease-type-ib
#13
Maha Mameesh, Anuradha Ganesh, Beena Harikrishna, Sana Al Zuhaibi, Patrick Scott, Sami Al Kalbani, Khalid Al Thihli
AIM: To report co-occurrence of two rare recessive conditions, the membrane frizzled-related protein (MFRP)-related ocular phenotype and glycogen storage disease type 1b (GSD-1b), in three siblings in an Omani family. BACKGROUND: Biallelic mutations in the MFRP gene (chromosome 11q23) result in a distinct ocular phenotype characterized by retinitis pigmentosa, foveoschisis, optic nerve head drusen, and posterior microphthalmos. GSD-1b is an autosomal-recessive disorder caused by mutations in SLC37A4 gene located in the same chromosomal region...
May 16, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28505013/disease-expression-in-nonexudative-age-related-macular-degeneration-varies-with-choroidal-thickness
#14
Richard F Spaide
PURPOSE: To investigate the relationship between subfoveal choroidal thickness and disease manifestation in a series of eyes with nonexudative age-related macular degeneration (AMD). METHODS: Retrospective study of eyes with nonexudative AMD. The extracellular deposits present, drusen and subretinal drusenoid deposits (SDD, pseudodrusen) along with a newly recognized form of drusen, pachydrusen, were graded and compared with choroidal thickness as determined by optical coherence tomography...
May 11, 2017: Retina
https://www.readbyqxmd.com/read/28501377/structural-changes-associated-with-delayed-dark-adaptation-in-age-related-macular-degeneration
#15
Inês Laíns, John B Miller, Dong H Park, Edem Tsikata, Samaneh Davoudi, Safa Rahmani, Jonathan Pierce, Rufino Silva, Teresa C Chen, Ivana K Kim, Demetrios Vavvas, Joan W Miller, Deeba Husain
PURPOSE: To examine the relationship between dark adaptation (DA) and optical coherence tomography (OCT)-based macular morphology in age-related macular degeneration (AMD). DESIGN: Prospective, cross-sectional study. PARTICIPANTS: Patients with AMD and a comparison group (>50 years) without any vitreoretinal disease. METHODS: All participants were imaged with spectral-domain OCT and color fundus photographs, and then staged for AMD (Age-related Eye Disease Study system)...
May 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28499057/adaptive-optics-scanning-laser-ophthalmoscopy-and-multimodal-imaging-of-peau-d-orange-in-pseudoxanthoma-elasticum
#16
Alex C Onishi, Peter L Nesper, Amani A Fawzi
A 41-year-old male with pseudoxanthoma elasticum who presented with progressive vision loss in his left periphery is discussed. Bilateral angioid streaks, optic disc drusen, choroidal neovascularization, and peau d'orange were present. Imaging of the area with peau d'orange with adaptive optics scanning laser ophthalmoscopy and en face optical coherence tomography at Bruch's membrane (BM) revealed a pattern identical to the patches of peau d'orange visible with conventional fundus imaging techniques. These results show that structural abnormalities at the level of BM, likely a result of calcification, correlate with the characteristic "orange peel" pattern known as peau d'orange...
May 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28491460/correlation-between-retinal-function-and-microstructural-foveal-changes-in-intermediate-age-related-macular-degeneration
#17
Serena Fragiotta, Carmela Carnevale, Alessandro Cutini, Enzo Maria Vingolo
PURPOSE: To assess foveal microstructural changes influencing retinal sensitivity (RS) and fixation stability using microperimeter MP-1 in intermediate age-related macular degeneration (AMD). METHODS: In this cross-sectional study, 22 eyes of 22 patients (mean age: 75 ± 9.02 years) with intermediate AMD were enrolled. Retinal sensitivity and bivariate contour ellipse area (BCEA) were obtained by microperimetry MP-1 (Humphrey 10-2 68-loci grid) under mesopic conditions...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28486730/die-randunscharfe-papille-eine-diagnostische-herausforderung
#18
Julia Biermann, Wolf Alexander Lagrèze
Correct differential diagnosis in cases of blurred optic disc margins is a challenging task for ophthalmologists. The reliable differentiation of pseudopapilloedema and true papilloedema has significant implications for proper patient management. Conditions that give rise to pseudopapilloedema include small crowded discs, tilted discs and optic nerve head drusen. Conditions that cause bilateral true swelling of the optic nerve head with initially good visual acuity include those that are secondary to raised intracranial pressure (optic disc edema, ODE)...
June 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28460051/quantitatively-measured-anatomic-location-and-volume-of-optic-disc-drusen-an-enhanced-depth-imaging-optical-coherence-tomography-study
#19
Lasse Malmqvist, Anne-Sofie Wessel Lindberg, Vedrana Andersen Dahl, Thomas Martini Jørgensen, Steffen Hamann
Purpose: Optic disc drusen (ODD) are found in up to 2.4% of the population and are known to cause visual field defects. The purpose of the current study was to investigate how quantitatively estimated volume and anatomic location of ODD influence optic nerve function. Methods: Anatomic location, volume of ODD, and peripapillary retinal nerve fiber layer and macular ganglion cell layer thickness were assessed in 37 ODD patients using enhanced depth imaging optical coherence tomography...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28448669/prevalence-of-undiagnosed-age-related-macular-degeneration-in-primary-eye-care
#20
David C Neely, Kevin J Bray, Carrie E Huisingh, Mark E Clark, Gerald McGwin, Cynthia Owsley
Importance: Age-related macular degeneration (AMD) is the leading cause of irreversible vision impairment in older adults in the United States, yet little is known about whether AMD is appropriately diagnosed in primary eye care. Objectives: To examine the prevalence of eyes with AMD in patients seen in primary eye care clinics who purportedly have normal macular health per their medical record and the association of AMD with patient and physician characteristics...
June 1, 2017: JAMA Ophthalmology
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