keyword
MENU ▼
Read by QxMD icon Read
search

Drusen

keyword
https://www.readbyqxmd.com/read/27914831/optic-nerve-head-drusen-prevalence-and-associated-factors-in-clinically-normal-subjects-measured-using-optical-coherence-tomography
#1
Mark P Ghassibi, Jason L Chien, Ramiz K Abumasmah, Jeffrey M Liebmann, Robert Ritch, Sung Chul Park
OBJECTIVE: To investigate the prevalence of optic nerve head drusen (ONHD) in clinically normal subjects using enhanced depth imaging (EDI) optical coherence tomography (OCT) and to evaluate associated factors. DESIGN: Prospective, cross-sectional, observational study. PARTICIPANTS: Total of 130 clinically normal subjects. METHODS: Serial horizontal and vertical EDI OCT B-scans (interval between scans, ∼30 μm) of the optic nerve head (ONH) were obtained in both eyes of clinically normal subjects...
November 30, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27886184/a-view-of-the-current-and-future-role-of-optical-coherence-tomography-in-the-management-of-age-related-macular-degeneration
#2
REVIEW
U Schmidt-Erfurth, S Klimscha, S M Waldstein, H Bogunović
Optical coherence tomography (OCT) has become an established diagnostic technology in the clinical management of age-related macular degeneration (AMD). OCT is being used for primary diagnosis, evaluation of therapeutic efficacy, and long-term monitoring. Computer-based advances in image analysis provide complementary imaging tools such as OCT angiography, further novel automated analysis methods as well as feature detection and prediction of prognosis in disease and therapy by machine learning. In early AMD, pathognomonic features such as drusen, pseudodrusen, and abnormalities of the retinal pigment epithelium (RPE) can be imaged in a qualitative and quantitative way to identify early signs of disease activity and define the risk of progression...
November 25, 2016: Eye
https://www.readbyqxmd.com/read/27876140/retinal-pigment-epithelium-cell-derived-exosomes-possible-relevance-to-cnv-in-wet-age-related-macular-degeneration
#3
Yao Tong, Ya-Li Zhou, Yi-Xiao Wang, Pei-Quan Zhao, Zhao-Yang Wang
Exosomes are small vesicles that are released by almost every cell type and play a crucial role in many physiological and pathological processes associated with different diseases. Specifically, they promote angiogenesis in the pathogenesis of some diseases. According to previous research, the proteins of exosomes taken from the aqueous humor (AH) of patients with wet-age related macular degeneration (AMD) may function as a new diagnostic biomarker of AMD, suggesting that exosomes may play an important role in the occurrence and development of choroidal neovascularization (CNV)...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27864062/en-face-optical-coherence-tomography-imaging-for-the-detection-of-nascent-geographic-atrophy
#4
Karen B Schaal, Giovanni Gregori, Philip J Rosenfeld
PURPOSE: To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). DESIGN: Retrospective observational case series. METHODS: Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high density Spectralis OCT B-scans and en face OCT images from the Cirrus OCT instrument...
November 15, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27843908/anterior-chamber-pathology-in-alagille-syndrome
#5
Derek K Ho, Alex V Levin, William V Anninger, David A Piccoli, Ralph C Eagle
BACKGROUND: Alagille syndrome is an autosomal dominant disorder characterized by neonatal cholestasis, characteristic facies, and cardiac abnormalities. Ocular abnormalities include posterior embryotoxon, mosaic pattern of iris stromal hypoplasia, microcornea, optic disc drusen, and pigmentary retinopathy. We present the second report of ocular pathology in two cases of Alagille syndrome. METHODS: Gross and histologic preparations of four eyes of two patients. RESULTS: Posterior embryotoxon is seen in both cases, with iris processes extending to the embryotoxon in case 1...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27834969/the-association-of-geographic-atrophy-and-decreased-renal-function-in-patients-with-age-related-macular-degeneration
#6
H B Leisy, A Rastogi, G Guevara, M Ahmad, R T Smith
PurposeThe purpose of the study was to investigate the association between area and presence of geographic atrophy (GA) and renal function, as measured by glomerular filtration rate (GFR).Patients and methodsWe retrospectively identified patients aged 50-90 years who were assigned an ICD-9 diagnosis code for age-related macular generation (AMD) between January 2012 and January 2016. Patients met inclusion criteria if they had at least one macular spectral domain optical coherence tomography volume scan, one provider note, and one GFR value in the electronic medical record...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27825655/mediterranean-diet-score-and-its-association-with-age-related-macular-degeneration-the-european-eye-study
#7
Ruth E Hogg, Jayne V Woodside, Alanna McGrath, Ian S Young, Jesus L Vioque, Usha Chakravarthy, Paulus T de Jong, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Astrid E Fletcher
PURPOSE: To examine associations between adherence to a Mediterranean diet and prevalence of age-related macular degeneration (AMD) in countries ranging from Southern to Northern Europe. DESIGN: Cross-sectional, population-based epidemiologic study. PARTICIPANTS: Of 5060 randomly sampled people aged 65 years or older from 7 study centers across Europe (Norway, Estonia, United Kingdom, France, Italy, Greece, and Spain), full dietary data were available in 4753...
November 5, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27820424/relevance-of-identifying-jag1-mutations-in-patients-with-isolated-posterior-embryotoxon
#8
Christophe Orssaud, Matthieu P Robert, Olivier Roche
PURPOSE: Although posterior embryotoxon (PE) has a high incidence in the general population, clinicians should exclude any sign of glaucoma in its presence. This anatomic abnormality is often referred to as "isolated" when the intraocular pressure is normal. Nevertheless, it may be the only sign of Alagille syndrome (AS) that can be clinically heterogenous, as presented here. This possibility must be known, to look for involvement of other organs, and in case of suspicion, mutation of the JAG1 gene must be considered...
December 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27817914/enhanced-depth-imaging-optical-coherence-tomography-of-optic-nerve-head-drusen-a-comparison-of-cases-with-and-without-visual-field-loss
#9
Ghislaine L Traber, Konrad P Weber, Mazen Sabah, Pearse A Keane, Gordon T Plant
PURPOSE: Enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD OCT) has been recognized as the most sensitive tool to diagnose optic nerve head drusen (ONHD). The relationship between OCT characteristics and visual loss has not been well documented. This study compares EDI SD OCT-determined morphologic characteristics of drusen in eyes with or without visual field (VF) defects. DESIGN: Descriptive study of patients attending the neuro-ophthalmology service of Moorfields Eye Hospital between January 2013 and October 2014...
November 3, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27816749/use-of-multicolor-imaging-in-the-assessment-of-suspected-papilledema-in-20-consecutive-children
#10
Andrew Malem, Gabriella De Salvo, Stephanie West
PURPOSE: To investigate the use of MultiColor Scanning Laser Imaging as an adjunct to traditional imaging modalities in the assessment of children with suspected disk swelling. METHODS: In this study of 20 consecutive children with suspected papilledema, MultiColor imaging was performed on all patients in addition to fundus examination, fundus autofluorescence, disk spectral domain optical coherence tomography (SD-OCT), and disk retinal nerve fiber layer thickness (RNFL) measurement...
November 2, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27814598/associations-of-alzheimer-s-disease-with-macular-degeneration
#11
Leonardo Biscetti, Elisa Luchetti, Andrea Vergaro, Paola Menduno, Carlo Cagini, Lucilla Parnetti
There is growing evidence of epidemiological, genetic, molecular and clinical links between Alzheimer's disease (AD) and age-related macular degeneration (AMD). Major interest in the relationship between AD and AMD has derived from the evidence that beta-amyloid, the main component of senile plaques, the hallmark of AD, is also an important component of drusen, the hallmark of AMD. This finding has a great potential in the present era of anti-amyloid agents for the treatment of AD. The connection between AD and AMD is also supported by the evidence that the two diseases share other pathophysiological factors, such as oxidative stress and neuroinflammation...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27806825/optic-disc-drusen-in-a-pediatric-patient-diagnosis-and-counselling-of-family
#12
Royala Zaka, Alyscia Cheema
No abstract text is available yet for this article.
October 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27805590/assessing-retinal-microglial-phagocytic-function-in-vivo-using-a-flow-cytometry-based-assay
#13
Salome Murinello, Stacey K Moreno, Matthew S Macauley, Susumu Sakimoto, Peter D Westenskow, Martin Friedlander
Microglia are the tissue resident macrophages of the central nervous system (CNS) and they perform a variety of functions that support CNS homeostasis, including phagocytosis of damaged synapses or cells, debris, and/or invading pathogens. Impaired phagocytic function has been implicated in the pathogenesis of diseases such as Alzheimer's and age-related macular degeneration, where amyloid-β plaque and drusen accumulate, respectively. Despite its importance, microglial phagocytosis has been challenging to assess in vivo...
October 18, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27800275/uveal-melanoma-current-trends-in-diagnosis-and-management
#14
REVIEW
Berçin Tarlan, Hayyam Kıratlı
Uveal melanoma, which is the most common primary intraocular malignancy in adults, arises from melanocytes within the iris, ciliary body and choroid. The diagnosis is based principally on clinical examination of the tumor with biomicroscopy and indirect ophthalmoscopy and confirmed by diagnostic techniques such as ultrasonography, fundus fluorescein angiography and optical coherence tomography. The clinical diagnosis of posterior uveal melanomas can be made when the classical appearance of a pigmented dome-shaped mass is detected on dilated fundus exam...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27800246/comet-lesions-in-patients-with-pseudoxanthoma-elasticum
#15
Sinan Tatlıpınar, Berna Şahan, Muhsin Altunsoy
Pseudoxanthoma elasticum (PXE) is a genetic multisystemic disorder affecting the skin, eyes and cardiovascular system. Basic fundoscopic findings in PXE result from Bruch's membrane involvement. The most important fundoscopic findings are angioid streaks. Other significant ocular findings are peau d'orange appearance, optic disc drusen, pattern dystrophy-like macular appearance, comet lesions, and choroidal neovascularization. Comet lesions are a pathognomonic ocular finding for PXE. The presence of both angioid streaks in the fundus and typical skin lesions should alert clinicians to PXE...
December 2015: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27794427/choriocapillaris-non-perfusion-is-associated-with-poor-visual-acuity-in-eyes-with-reticular-pseudodrusen
#16
Peter L Nesper, Brian T Soetikno, Amani A Fawzi
PURPOSE: To study choriocapillaris blood flow in age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA) and study its correlation to vision (VA) in eyes with reticular pseudodrusen (RPD) versus those with drusen without RPD (drusen). DESIGN: Cross-sectional study METHODS: Patients with either drusen or RPD in early AMD underwent OCTA imaging of the superior, inferior, and/or nasal macula. We quantified "percent choriocapillaris area of non-perfusion" (PCAN) in eyes with RPD versus those with drusen...
October 26, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27793356/optical-coherence-tomography-reflective-drusen-substructures-predict-progression-to-geographic-atrophy-in-age-related-macular-degeneration
#17
Malini Veerappan, Abdul-Karim M El-Hage-Sleiman, Vincent Tai, Stephanie J Chiu, Katrina P Winter, Sandra S Stinnett, Thomas S Hwang, G Baker Hubbard, Michelle Michelson, Randall Gunther, Wai T Wong, Emily Y Chew, Cynthia A Toth
PURPOSE: Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tomography-reflective drusen substructures (ODS) and examine their associations with age-related macular degeneration (AMD)-related features and AMD progression. DESIGN: Retrospective analysis in a prospective study...
December 2016: Ophthalmology
https://www.readbyqxmd.com/read/27776188/analysis-of-macular-drusen-and-blood-test-results-in-945-macaca-fascicularis
#18
Koji M Nishiguchi, Yu Yokoyama, Yusuke Fujii, Kosuke Fujita, Yusuke Tomiyama, Ryo Kawasaki, Toshinori Furukawa, Fumiko Ono, Nobuhiro Shimozawa, Mutsumi Togo, Michihiro Suzuki, Toru Nakazawa
Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the development of age-related macular degeneration (AMD), one of the leading causes of blindness worldwide. It is established that inflammation contributes to the pathogenesis of drusen and AMD. However, development of a preemptive therapeutic strategy targeting macular drusen and AMD has been impeded by the lack of relevant animal models because most laboratory animals lack macula, an anatomic feature present only in humans and a subset of monkeys...
2016: PloS One
https://www.readbyqxmd.com/read/27768796/epidemiology-of-reticular-pseudodrusen-in-age-related-macular-degeneration-the-rotterdam-study
#19
Gabriëlle H S Buitendijk, Ada J Hooghart, Corina Brussee, Paulus T V M de Jong, Albert Hofman, Johannes R Vingerling, Caroline C W Klaver
Purpose: Reticular pseudodrusen (RPD) are considered to be a distinct feature in AMD. Population studies have studied the epidemiology of RPD using standard color fundus photographs (CFP). However, recent studies have shown that RPD are better imaged using near-infrared (NIR) imaging. We studied the epidemiology of RPD in a large population-based study using NIR and CFP. Methods: Participants aged 65+ years from the Rotterdam Study underwent ophthalmologic examination including NIR and CFP...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27760262/associations-between-retinal-pigment-epithelium-and-drusen-volume-changes-during-the-lifecycle-of-large-drusenoid-pigment-epithelial-detachments
#20
Chandrakumar Balaratnasingam, Lawrence A Yannuzzi, Christine A Curcio, William H Morgan, Giuseppe Querques, Vittorio Capuano, Eric Souied, Jesse Jung, K Bailey Freund
Purpose: Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT). Methods: Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth and collapse were evaluated. Volumetric calculations and piece-wise linear regression analysis were used to determine the breakpoint between growth and collapse...
October 1, 2016: Investigative Ophthalmology & Visual Science
keyword
keyword
114811
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"