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Drusen

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https://www.readbyqxmd.com/read/29350686/fuchs-endothelial-corneal-dystrophy-and-macular-drusen-evidence-for-coincidence
#1
M Matthaei, E Elsner, A Caramoy, W Adler, S Siebelmann, F Schaub, C Skevas, S Liakopoulos, B Bachmann, C Cursiefen, L M Heindl
No abstract text is available yet for this article.
January 19, 2018: Eye
https://www.readbyqxmd.com/read/29346242/prevalence-and-clinical-characteristics-of-pachydrusen-in-polypoidal-choroidal-vasculopathy-multimodal-image-study
#2
Junwon Lee, Suk Ho Byeon
PURPOSE: To investigate the prevalence of a newly defined drusen type, pachydrusen, soft drusen, and subretinal drusenoid deposits in eyes with polypoidal choroidal vasculopathy and fellow eyes and the relationship between each drusen type and the choroidal thickness, vascular morphology, and hyperpermeability. METHODS: The 169 eyes of 90 patients with polypoidal choroidal vasculopathy were retrospectively reviewed. The prevalence of each drusen type was evaluated using color fundus photography and optical coherence tomography...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29340648/a-novel-strategy-for-quantifying-choriocapillaris-flow-voids-using-swept-source-oct-angiography
#3
Qinqin Zhang, Fang Zheng, Elie H Motulsky, Giovanni Gregori, Zhongdi Chu, Chieh-Li Chen, Chunxia Li, Luis de Sisternes, Mary Durbin, Philip J Rosenfeld, Ruikang K Wang
Purpose: To achieve reproducible imaging of the choriocapillaris and associated flow voids using swept-source OCT angiography (SS-OCTA). Methods: Subjects were enrolled and SS-OCTA was performed using the 3 × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAG) algorithm. The choriocapillaris was defined as a slab from the outer boundary of Bruch's membrane (BM) to approximately 20 μm below BM. Compensation for the shadowing effect caused by the RPE and BM complex on the choriocapillaris angiogram was achieved by using the structural information from the same slab...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29329580/evidence-for-the-activation-of-pyroptotic-and-apoptotic-pathways-in-rpe-cells-associated-with-nlrp3-inflammasome-in-the-rodent-eye
#4
Jiangyuan Gao, Jing Z Cui, Eleanor To, Sijia Cao, Joanne A Matsubara
BACKGROUND: Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of the disease. However, the exact mechanisms for RPE degeneration in AMD are still unresolved. The prevailing theories consider that each cell death pathway works independently and without regulation of each other. Building upon our previous work in which we induced a short burst of inflammasome activity in vivo, we now investigate the effects of prolonged inflammasome activity on RPE cell death mechanisms in rats...
January 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29306951/longitudinal-analysis-of-drusen-volume-in-intermediate-age-related-macular-degeneration-using-two-spectral-domain-optical-coherence-tomography-scan-patterns
#5
Sarah Thiele, Jennifer Nadal, Monika Fleckenstein, Petra P Fang, Maximilian Pfau, Matthias Schmid, Rui Hua, Frank G Holz, Steffen Schmitz-Valckenberg
PURPOSE: To evaluate two different spectral-domain optical coherence tomography (SD-OCT) scan patterns in eyes with intermediate age-related macular degeneration (AMD) for the longitudinal assessment of drusen volume. METHODS: The data of 38 eyes of 38 AMD patients (age 69.97 ± 6.08 years) were included. The longitudinal drusen volume over 4 years was analyzed by annual SD-OCT raster scanning (field size 20 × 15°). Two raster scan patterns (A/B) differed in the distance between neighboring B-scans (240 vs...
January 5, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29302837/up-regulated-pro-inflammatory-micrornas-mirnas-in-alzheimer-s-disease-ad-and-age-related-macular-degeneration-amd
#6
Aileen I Pogue, Walter J Lukiw
Alzheimer's disease (AD) of the brain neocortex and age-related macular degeneration (AMD) of the retina are two complex neurodegenerative disorders, which (i) involve the progressive dysregulation and deterioration of multiple neurobiological signaling pathways, (ii) exhibit the temporal accumulation of pro-inflammatory lesions including the amyloid beta (Aβ) peptide-containing senile plaques of AD and the drusen of AMD, and (iii) culminate in an insidious inflammatory neurodegeneration ending, respectively, in neural cell atrophy and death and progressive loss of cognition and central visual function...
January 4, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29300212/volumetric-measurement-of-optic-nerve-head-drusen-using-swept-source-optical-coherence-tomography-erratum
#7
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29283116/soft-drusen-or-not
#8
Carol L Shields, Elizabeth B Elimimian, Fairooz P Manjandavida
No abstract text is available yet for this article.
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29282883/measuring-polarization-changes-in-the-human-outer-retina-with-polarization-sensitive-optical-coherence-tomography
#9
Barry Cense, Donald T Miller, Brett J King, Thomas Theelen, Ann E Elsner
Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age-related macular degeneration. However earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization-altering properties. To test this hypothesis, we developed a method based on polarization-sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (<25 yr) and 10 older (>54 yr) subjects...
December 28, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29260196/development-and-validation-of-a-risk-score-for-age-related-macular-degeneration-the-stars-questionnaire
#10
MULTICENTER STUDY
Cécile Delcourt, Eric Souied, Alice Sanchez, Francesco Bandello
Purpose: To develop and validate a risk score for AMD based on a simple self-administered questionnaire. Methods: Risk factors having shown the most consistent associations with AMD were included in the STARS (Simplified Théa AMD Risk-Assessment Scale) questionnaire. Two studies were conducted, one in Italy (127 participating ophthalmologists) and one in France (80 participating ophthalmologists). During 1 week, participating ophthalmologists invited all their patients aged 55 years or older to fill in the STARS questionnaire...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29260086/retinal-findings-in-membranoproliferative-glomerulonephritis
#11
Ahmad M Mansour, Luiz H Lima, J Fernando Arevalo, Miguel Hage Amaro, Virginia Lozano, Alaa Bou Ghannam, Errol W Chan
Purpose: To assess the evolution of retinal findings in patients with membranoproliferative glomerulonephritis (MPGN) by funduscopy, intravenous fluorescein angiography and optical coherence tomography. Observations: Three women and one man were followed for a period of 1.5-37 years. Four patients (8 eyes) had drusen detected at first fundus exam at age 24, 29, 50 and 55. Three patients (6 eyes) had diffuse thickening of Bruch's membrane, and two patients (3 eyes) had detachment of the retinal pigment epithelium with serous retinal detachment...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29242932/substantial-visual-field-loss-associated-with-giant-optic-disc-drusen
#12
Lasse Malmqvist, Alexander Kyhnel, Steffen Hamann
No abstract text is available yet for this article.
December 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29237169/outer-retina-and-choroidal-thickness-in-intermediate-age-related-macular-degeneration-reticular-pseudodrusen-findings
#13
Pedro Camacho, Marco Dutra-Medeiros, Diogo Cabral, Rufino Silva
PURPOSE: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). METHODS: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 µm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study...
December 14, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29224928/association-of-rare-predicted-loss-of-function-variants-in-cellular-pathways-with-sub-phenotypes-in-age-related-macular-degeneration
#14
Alexandra Pietraszkiewicz, Freekje van Asten, Alan Kwong, Rinki Ratnapriya, Goncalo Abecasis, Anand Swaroop, Emily Y Chew
PURPOSE: To investigate the association of rare predicted loss-of-function (pLoF) variants within age-related macular degeneration (AMD) risk loci and AMD sub-phenotypes. DESIGN: Case-control study. PARTICIPANTS: Participants of AREDS, AREDS2, and Michigan Genomics Initiative. METHODS: Whole genome sequencing data were analyzed for rare pLoF variants (frequency <0.1%) in the regions of previously identified 52 independent risk variants known to be associated with AMD...
December 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29219932/cuticular-drusen-in-an-indigenous-australian
#15
William J Cunningham, Chandrakumar Balaratnasingam, Yi Chen, Fred K Chen
BACKGROUND/PURPOSE: To report a case of cuticular drusen in an indigenous Australian. METHODS: A 37-year-old indigenous (aboriginal) Australian woman from a remote Western Australian town presented with a 2-month history of vision loss. Clinical history, examination, and multimodal retinal imaging data from spectral domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography were analyzed. RESULTS: Multimodal imaging confirmed cuticular drusen complicated by a right choroidal neovascularization with pigment epithelial detachment and a left foveal vitelliform lesion...
December 5, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29204763/automated-segmentation-and-quantification-of-drusen-in-fundus-and-optical-coherence-tomography-images-for-detection-of-armd
#16
Samina Khalid, M Usman Akram, Taimur Hassan, Amina Jameel, Tehmina Khalil
Age-related macular degeneration (ARMD) is one of the most common retinal syndromes that occurs in elderly people. Different eye testing techniques such as fundus photography and optical coherence tomography (OCT) are used to clinically examine the ARMD-affected patients. Many researchers have worked on detecting ARMD from fundus images, few of them also worked on detecting ARMD from OCT images. However, there are only few systems that establish the correspondence between fundus and OCT images to give an accurate prediction of ARMD pathology...
December 4, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29203329/bruch-s-membrane-opening-on-optical-coherence-tomography-in-pediatric-papilledema-and-pseudopapilledema
#17
Atalie C Thompson, M Tariq Bhatti, Mays A El-Dairi
PURPOSE: To determine whether the diameter of Bruch's membrane opening (BMO) can distinguish mild papilledema from pseudopapilledema using optical coherence tomography (OCT). METHODS: The medical records of pediatric patients with pseudopapilledma due to optic nerve head (ONH) drusen, patients with papilledema, and normal control subjects were reviewed retrospectively. All eyes underwent OCT imaging of the BMO and retinal nerve fiber layer (RNFL). Transverse horizontal diameter of the BMO and papillary height were measured...
December 1, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29188102/automated-drusen-detection-in-dry-age-related-macular-degeneration-by-multiple-depth-en-face-optical-coherence-tomography
#18
Rui Zhao, Acner Camino, Jie Wang, Ahmed M Hagag, Yansha Lu, Steven T Bailey, Christina J Flaxel, Thomas S Hwang, David Huang, Dengwang Li, Yali Jia
We introduce a method to automatically detect drusen in dry age-related macular degeneration (AMD) from optical coherence tomography with minimum need for layer segmentation. The method is based on the en face detection of drusen areas in C-scans at certain distances above the Bruch's membrane, circumventing the difficult task of pathologic retinal pigment epithelium segmentation. All types of drusen can be detected, including the challenging subretinal drusenoid deposits (pseudodrusen). The high sensitivity and accuracy demonstrated here shows its potential for detection of drusen onset in early AMD...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29186723/optical-coherence-tomography-angiography-in-optic-nerve-drusen
#19
Gilda Cennamo, Sabrina Tebaldi, Francesca Amoroso, Dimitri Arvanitis, Mariangelica Breve, Giovanni Cennamo
AIM: To determine the efficacy of optical coherence tomography angiography (OCT-A) in diagnosing optic nerve head flow impairment in patients with optic nerve drusen. METHODS: Patients affected by optic-nerve head drusen (ONHD) attending the Eye Clinic of the Federico II University of Naples were enrolled in this prospective case series between October 2015 and October 2016. Each patient underwent evaluation of best corrected visual acuity (BCVA), Goldman applanation tonometry, slit-lamp biomicroscopy, fundus examination, standard visual-field testing (perimetry), spectral domain (SD)-OCT and OCT-A...
November 30, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29185101/association-between-traditional-clinical-high-risk-features-and-gene-expression-profile-classification-in-uveal-melanoma
#20
Brandon T Nguyen, Ryan S Kim, Maria E Bretana, Eric Kegley, Amy C Schefler
PURPOSE: To evaluate the association between traditional clinical high-risk features of uveal melanoma patients and gene expression profile (GEP). METHODS: This was a retrospective, single-center, case series of patients with uveal melanoma. Eighty-three patients met inclusion criteria for the study. Patients were examined for the following clinical risk factors: drusen/retinal pigment epithelium (RPE) changes, vascularity on B-scan, internal reflectivity on A-scan, subretinal fluid (SRF), orange pigment, apical tumor height/thickness, and largest basal dimensions (LBD)...
November 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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