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https://www.readbyqxmd.com/read/28324113/microrna-expression-patterns-involved-in-amyloid-beta-induced-retinal-degeneration
#1
Peirong Huang, Junran Sun, Fenghua Wang, Xueting Luo, Jingyang Feng, Qing Gu, Te Liu, Xiaodong Sun
Purpose: Dry age-related macular degeneration (AMD) is characterized by the accumulation of drusen under Bruch's membrane, and amyloid beta (Aβ) is speculated to be one of the key pathologic factors. While the detrimental effects of Aβ on retinas have been widely explored, Aβ-induced epigenetic regulatory changes have yet to be fully investigated. We therefore aimed to identify the microRNA (miRNA) expression profiles in an Aβ-induced mouse model of retinal degeneration. Methods: C57BL/6 mice were intravitreally injected with Aβ1-40 or PBS and the eye tissues were collected for hematoxylin and eosin (H&E) staining, apoptosis immunofluorescence staining, and miRNA profiling...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28291154/assessment-of-drusen-and-other-retinal-degenerative-changes-in-patients-with-hereditary-hemochromatosis
#2
Moreno Menghini, Christian Prünte, Pierre A Krayenbuehl, Albina Nowak
PURPOSE: Iron can exert oxidative damage, and increased accumulation is believed to play a role in age-related macular degeneration. Hereditary hemochromatosis leads to an increase in total body iron. Patients with HH were assessed for drusen and other retinal changes. METHODS: Descriptive uncontrolled study of spectral-domain optical coherence tomography, short-wavelength autofluorescence, and color fundus images from patients with HH were used. Diagnosis of HH was established by measuring ferritin and transferrin saturation, and confirmed by genetic testing...
March 13, 2017: Retina
https://www.readbyqxmd.com/read/28282423/age-related-macular-degeneration-phenotypes-are-associated-with-increased-tumor-necrosis-alpha-and-subretinal-immune-cells-in-aged-cxcr5-knockout-mice
#3
Hu Huang, Ying Liu, Lei Wang, Wen Li
The role of chemokine receptor in age-related macular degeneration (AMD) remains elusive. The objective of this study is to investigate the role of chemokine receptor Cxcr5 in the pathogenesis of AMD. Cxcr5 gene expression levels (mRNA and protein) are higher in the retina and retinal pigment epithelium (RPE) of aged C57BL/6 wild type mice than younger ones. Vascular and glial cells express Cxcr5 and its ligand Cxcl13 in mouse retina. Aged Cxcr5 knockout (-/-) mice develop both early and late AMD-like pathological features...
2017: PloS One
https://www.readbyqxmd.com/read/28278345/photographic-documentation-of-optic-disc-drusen-over-more-than-50-years
#4
Lasse Malmqvist, Steffen Hamann
No abstract text is available yet for this article.
March 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28275527/individual-drusen-segmentation-and-repeatability-and-reproducibility-of-their-automated-quantification-in-optical-coherence-tomography-images
#5
Luis de Sisternes, Gowtham Jonna, Margaret A Greven, Qiang Chen, Theodore Leng, Daniel L Rubin
PURPOSE: To introduce a novel method to segment individual drusen in spectral-domain optical coherence tomography (SD-OCT), and evaluate its accuracy, and repeatability/reproducibility of drusen quantifications extracted from the segmentation results. METHODS: Our method uses a smooth interpolation of the retinal pigment epithelium (RPE) outer boundary, fitted to candidate locations in proximity to Bruch's Membrane, to identify regions of substantial lifting in the inner-RPE or inner-segment boundaries, and then separates and evaluates individual druse independently...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28270492/retinal-pigment-epithelial-features-indicative-of-neovascular-progression-in-age-related-macular-degeneration
#6
Philipp K Roberts, Bernhard Baumann, Ferdinand G Schlanitz, Stefan Sacu, Matthias Bolz, Michael Pircher, Michael Hagmann, Christoph K Hitzenberger, Ursula Schmidt-Erfurth
BACKGROUND/AIMS: To identify characteristic retinal pigment epithelium (RPE) changes in fellow eyes of patients with neovascular age-related macular degeneration (nAMD) using polarisation-sensitive optical coherence tomography (PS-OCT). METHODS: Thirty-one fellow eyes of 31 patients with unilateral nAMD were evaluated in this cohort study of a prospective interventional trial. PS-OCT as well as conventional imaging including spectral-domain (SD)-OCT and fluorescein angiography (FA) were performed using a standardised protocol...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251353/prevalence-and-characteristics-of-pseudodrusen-subtypes-in-advanced-age-related-macular-degeneration
#7
Taiyo Shijo, Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Wataru Kikushima, Naohiko Tanabe, Hiroyuki Iijima
PURPOSE: The purpose of our study was to investigate the clinical and genetic characteristics of pseudodrusen subtypes and their incidence in advanced age-related macular degeneration (AMD). METHODS: We studied 84 eyes from 84 patients with pseudodrusen associated with advanced AMD, including typical AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), and geographic atrophy (GA). Multiple imaging modalities, including color fundus photography, spectral-domain optical coherence tomography (SD-OCT), near-infrared reflectance, and fundus autofluorescence, were employed to diagnose pseudodrusen and its subtypes...
March 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28249091/subretinal-glial-membranes-in-eyes-with-geographic-atrophy
#8
Malia M Edwards, D Scott McLeod, Imran A Bhutto, Rhonda Grebe, Maeve Duffy, Gerard A Lutty
Purpose: Müller cells create the external limiting membrane (ELM) by forming junctions with photoreceptor cells. This study evaluated the relationship between focal photoreceptors and RPE loss in geographic atrophy (GA) and Müller cell extension into the subretinal space. Methods: Human donor eyes with no retinal disease or geographic atrophy (GA) were fixed and the eye cups imaged. The retinal posterior pole was stained for glial fibrillary acidic protein (GFAP; astrocytes and activated Müller cells) and vimentin (Müller cells) while the submacular choroids were labeled with Ulex Europaeus Agglutinin lectin (blood vessels)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28206671/surgery-for-cataracts-in-people-with-age-related-macular-degeneration
#9
REVIEW
Heather Casparis, Kristina Lindsley, Irene C Kuo, Shameema Sikder, Neil M Bressler
BACKGROUND: Cataract and age-related macular degeneration (AMD) are common causes of decreased vision that often occur simultaneously in people over age 50. Although cataract surgery is an effective treatment for cataract-induced visual loss, some clinicians suspect that such an intervention may increase the risk of worsening of underlying AMD and thus have deleterious effects on vision. OBJECTIVES: The objective of this review was to evaluate the effectiveness and safety of cataract surgery compared with no surgery in eyes with AMD...
February 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28196054/dynamism-of-dot-subretinal-drusenoid-deposits-in-age-related-macular-degeneration-demonstrated-with-adaptive-optics-imaging
#10
Yuhua Zhang, Xiaolin Wang, Pooja Godara, Tianjiao Zhang, Mark E Clark, C Douglas Witherspoon, Richard F Spaide, Cynthia Owsley, Christine A Curcio
PURPOSE: To investigate the natural history of dot subretinal drusenoid deposits (SDD) in age-related macular degeneration, using high-resolution adaptive optics scanning laser ophthalmoscopy. METHODS: Six eyes of four patients with intermediate age-related macular degeneration were studied at baseline and 1 year later. Individual dot SDD within the central 30° retina were examined with adaptive optics scanning laser ophthalmoscopy and optical coherence tomography...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28186886/joint-segmentation-of-retinal-layers-and-focal-lesions-in-3d-oct-data-of-topologically-disrupted-retinas
#11
Jelena Novosel, Koenraad Vermeer, Jan H de Jong, Ziyuan Wang, Lucas Van Vliet
Accurate quantification of retinal structures in 3D optical coherence tomography data of eyes with pathologies provides clinically relevant information. We present an approach to jointly segment retinal layers and lesions in eyes with topology-disrupting retinal diseases by a loosely coupled level sets framework. In the new approach, lesions are modelled as an additional space-variant layer delineated by auxiliary interfaces. Furthermore, the segmentation of interfaces is steered by local differences in the signal between adjacent retinal layers thereby allowing the approach to handle local intensity variations...
February 8, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28180131/semiautomated-segmentation-and-analysis-of-retinal-layers-in-three-dimensional-spectral-domain-optical-coherence-tomography-images-of-patients-with-atrophic-age-related-macular-degeneration
#12
Zhihong Hu, Yue Shi, Kiran Nandanan, Srinivas R Sadda
Historically, regular drusen and geographic atrophy (GA) have been recognized as the hallmarks of nonneovascular age-related macular degeneration (AMD). Recent imaging developments have revealed another distinct nonneovascular AMD phenotype, reticular pseudodrusen (RPD). We develop an approach to semiautomatically quantify retinal surfaces associated with various AMD lesions (i.e., regular drusen, RPD, and GA) in spectral domain (SD) optical coherence tomography (OCT) images. More specifically, a graph-based algorithm was used to segment multiple retinal layers in SD-OCT volumes...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/28169876/association-of-drusen-volume-with-choroidal-parameters-in-nonneovascular-age-related-macular-degeneration
#13
Siva Balasubramanian, Jianqin Lei, Muneeswar G Nittala, Swetha B Velaga, Jonathan Haines, Margaret A Pericak-Vance, Dwight Stambolian, SriniVas R Sadda
PURPOSE: The choroid is thought to be relevant to the pathogenesis of nonneovascular age-related macular degeneration, but its role has not yet been fully defined. In this study, we evaluate the relationship between the extent of macular drusen and specific choroidal parameters, including thickness and intensity. METHODS: Spectral domain optical coherence tomography images were collected from two distinct, independent cohorts with nonneovascular age-related macular degeneration: Amish (53 eyes of 34 subjects) and non-Amish (40 eyes from 26 subjects)...
February 6, 2017: Retina
https://www.readbyqxmd.com/read/28152142/drusen-on-demand-authors-describe-a-novel-culture-system-for-generating-subrpe-deposits
#14
Robert F Mullins
No abstract text is available yet for this article.
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28149006/role-of-lipids-in-retinal-vascular-and-macular-disorders
#15
REVIEW
Gunjan Prakash, Rachit Agrawal, Tanie Natung
Retinal diseases are significant by increasing problem in every part of the world. While excellent treatment has emerged for various retinal diseases, treatment for early disease is lacking due to an incomplete understanding of all molecular events. With aging, there is a striking accumulation of neutral lipids in Bruch's membrane. These neutral lipids leads to the creation of a lipid wall at the same locations where drusen and basal linear deposit, pathognomonic lesions of Age-related macular degeneration, subsequently form...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28146236/subretinal-pigment-epithelial-deposition-of-drusen-components-including-hydroxyapatite-in-a-primary-cell-culture-model
#16
Matthew G Pilgrim, Imre Lengyel, Antonio Lanzirotti, Matt Newville, Sarah Fearn, Eszter Emri, Jonathan C Knowles, Jeffrey D Messinger, Russell W Read, Clyde Guidry, Christine A Curcio
Purpose: Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane are hallmarks of early AMD. We examined whether cultured RPE cells could produce extracellular deposits containing all of these molecular components. Methods: Retinal pigment epithelium cells isolated from freshly enucleated porcine eyes were cultured on Transwell membranes for up to 6 months...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28141766/choroidal-nevus-a-review-of-prevalence-features-genetics-risks-and-outcomes
#17
Jason L Chien, Kareem Sioufi, Thamolwan Surakiatchanukul, Jerry A Shields, Carol L Shields
PURPOSE OF REVIEW: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus. RECENT FINDINGS: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus is associated with higher lifetime unopposed estrogen and greater BMI...
January 30, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28139892/multifocal-visual-evoked-potentials-for-quantifying-optic-nerve-dysfunction-in-patients-with-optic-disc-drusen
#18
Lasse Malmqvist, Luis de Santiago, Luciano Boquete, Steffen Hamann
PURPOSE: To explore the applicability of multifocal visual evoked potentials (mfVEPs) for research and clinical diagnosis in patients with optic disc drusen (ODD). This is the first assessment of mfVEP amplitude in patients with ODD. METHODS: MfVEP amplitude and latency from 33 patients with ODD and 22 control subjects were examined. Mean amplitude, mean inner ring (IR) amplitude (0.87-5.67° of visual field) and mean outer ring amplitude (5.68-24° of visual field) were calculated using signal-to-noise ratio (SNR) and peak-to-peak analysis...
January 31, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28132833/nicotinamide-ameliorates-disease-phenotypes-in-a-human-ipsc-model-of-age-related-macular-degeneration
#19
Janmeet S Saini, Barbara Corneo, Justine D Miller, Thomas R Kiehl, Qingjie Wang, Nathan C Boles, Timothy A Blenkinsop, Jeffrey H Stern, Sally Temple
Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the elderly. There are no disease-altering therapies for dry AMD, which is characterized by accumulation of subretinal drusen deposits and complement-driven inflammation. We report the derivation of human-induced pluripotent stem cells (hiPSCs) from patients with diagnosed AMD, including two donors with the rare ARMS2/HTRA1 homozygous genotype...
January 21, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28114590/intraocular-vascular-endothelial-growth-factor-levels-in-pachychoroid-neovasculopathy-and-neovascular-age-related-macular-degeneration
#20
Masayuki Hata, Kenji Yamashiro, Sotaro Ooto, Akio Oishi, Hiroshi Tamura, Manabu Miyata, Naoko Ueda-Arakawa, Ayako Takahashi, Akitaka Tsujikawa, Nagahisa Yoshimura
Purpose: To investigate the difference in intraocular vascular endothelial growth factor (VEGF) concentration between pachychoroid neovasculopathy and neovascular age-related macular degeneration (nAMD) and its associations with responses to three monthly anti-VEGF injections as an initial treatment for the two conditions. Methods: This study included nine eyes with treatment-naïve pachychoroid neovasculopathy and 21 eyes with treatment-naïve nAMD. Before the initial intravitreal anti-VEGF injection, aqueous humor samples were collected and the concentration of VEGF was measured using enzyme-linked immunosorbent assay...
January 1, 2017: Investigative Ophthalmology & Visual Science
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