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https://www.readbyqxmd.com/read/28454425/whole-body-low-dose-computed-tomography-in-multiple-myeloma-staging-superior-diagnostic-performance-in-the-detection-of-bone-lesions-vertebral-compression-fractures-rib-fractures-and-extraskeletal-findings-compared-to-radiography-with-similar-radiation-exposure
#1
Lukas Lambert, Petr Ourednicek, Zuzana Meckova, Giampaolo Gavelli, Jan Straub, Ivan Spicka
The primary objective of the present prospective study was to compare the diagnostic performance of conventional radiography (CR) and whole-body low-dose computed tomography (WBLDCT) with a comparable radiation dose reconstructed using hybrid iterative reconstruction technique, in terms of the detection of bone lesions, skeletal fractures, vertebral compressions and extraskeletal findings. The secondary objective was to evaluate lesion attenuation in relation to its size. A total of 74 patients underwent same-day skeletal survey by CR and WBLDCT...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454392/klf7-overexpression-in-human-oral-squamous-cell-carcinoma-promotes-migration-and-epithelial-mesenchymal-transition
#2
Xiaojun Ding, Xinhao Wang, Yiming Gong, Hong Ruan, Yang Sun, Youcheng Yu
Krüppel-like factor 7 (KLF7) is a member of the KLF family of zinc finger transcription factors, and was the first KLF cloned using complementary DNA and polymerase chain reaction (PCR) techniques with human vascular endothelial cells as a template. In addition, KLF7 is known as the ubiquitous Krüppel-like factor, as it is widely expressed in numerous human tissues at low levels. In the present study, the function of KLF7 in migration and epithelial-mesenchymal transition (EMT), which are associated with tumor progression, was investigated in human oral squamous cell carcinoma (OSCC) cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454331/centrosome-amplification-in-chondrosarcomas-a-primary-cell-culture-and-cryopreserved-tumor-sample-study
#3
Carla Aparecida Pinheiro, Iberê Cauduro Soares, Valter Penna, Jeremy Squire, Rui Manuel Vieira Reis, Sandra Regina Morini da Silva, Isabela de Carvalho, Marjori Leiva Camparoto, Maicon Fernando Zanon da Silva, Adhemar Longatto Longatto Filho
The genetics background underlying the aggressiveness of chondrosarcoma (CS) is poorly understood. One possible cause of malignant transformation is chromosomal instability, which involves an error in mitotic segregation due to numerical and/or functional abnormalities of centrosomes. The present study aimed to evaluate centrosome amplification in cryopreserved samples of tumor tissue from patients with CS. An analysis was performed on 3 primary cultures of tumors from patients who underwent surgery between January 2012 and December 2012 at the Department of Orthopedics at the Barretos Cancer Hospital (Barretos, Brazil)...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454327/stereotactic-radiotherapy-in-the-treatment-of-local-recurrences-of-esophageal-cancer
#4
Marcel Matzenauer, David Vrána, Zuzana Vlachová, Rene Aujesky, Radek Vrba, Cestmir Neoral, Bohuslav Melichar
Esophageal cancer (EC) consists of tumors with a generally poor prognosis, and treatment options for patients with disease recurrence are extremely limited. Due to this poor patient prognosis, the possible treatment toxicity should be carefully balanced against its potential benefit and patient quality of life. Stereotactic body radiotherapy (SBRT) is a rapidly expanding novel technique combining a short treatment time together with high local efficacy and an acceptable toxicity profile. There are no publications thus far presenting data regarding the usage of SBRT utilizing a conventional linear accelerator in locally recurrent EC patients...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454290/a-multi-shrna-vector-enhances-the-silencing-efficiency-of-exogenous-and-endogenous-genes-in-human-cells
#5
Yanjie Weng, Ying Shi, Xi Xia, Wenjuan Zhou, Hongyan Wang, Changyu Wang
RNA interference (RNAi) is a powerful technology for suppressing gene function. In most studies, small interfering RNAs (siRNAs) consist of one short hairpin RNA (shRNA) and, therefore, are often unable to achieve loss-of-function of their target genes. In the current study, an RNAi vector containing three shRNAs under the control of three RNA polymerase III U6 promoters was constructed. RNAi vectors containing one or two shRNAs were generated for comparisons. A pilot study targeting exogenously expressed DsRed in the HEK293 cell line revealed promising effects and a high selectivity for the multi-shRNA RNAi vector...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454289/iris-metastasis-as-the-first-sign-of-small-cell-lung-cancer-a-case-report
#6
Shi-Liang Liu, Yu-Hong Nie, Tao He, Xi-Xi Yan, Yi-Qiao Xing
The current study documents an unusual case of iris metastasis as the first sign of small cell lung cancer (SCLC) and reviews the relevant literature to increase understanding and awareness of this rare condition. A 59-year-old male chronic smoker presented with a painful and red right eye without any disturbance of vision. The patient also complained of associated chronic cough and anorexia. Upon examination, an exfoliative, pinkish-white lesion of the right iris was observed. A systemic work-up was performed, which incidentally detected metastatic SCLC in the lower lobe of the right lung and was confirmed by histopathological examination...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454223/surgical-treatment-of-solid-hemangioblastomas-of-the-posterior-fossa-a-report-of-28-cases
#7
Hua Cui, Jian Zou, Ying-Hui Bao, Ming-Sheng Wang, Yong Wang
This study evaluated the clinical features, treatment strategies and outcomes of solid hemangioblastomas in 28 patients diagnosed with hypervascular lesions in the posterior fossa. Preoperative embolization of the feeding arteries had limited effects, with only 7 patients benefitting from it for the reduction of intraoperative hemorrhage. The tumor was completely removed in all patients, and 22 patients had a full recovery, while 6 patients, all of whom had van Hippel Lindau disease, developed recurrences. The present study demonstrated that meticulous en bloc surgical resection was the optimal treatment for solid hemangioblastomas of the posterior fossa...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454198/-no-magic-bullet-genetic-diagnostics-and-predictive-testing
#8
Heiko Witt
The enormous increase in knowledge about the genetic basis of human diseases, combined with the rapid development of genetic techniques, has led to the possible use of genetic tests in medical diagnostics to a degree previously unknown. In addition, predictive genetic diagnostics has the aim of identifying hereditary disease risks in healthy individuals in order to take precautionary measures. However, the assessment of genetic findings is still subject to numerous problems. In particular, in the case of disease prediction, only probability statements can be made since endogenous and exogenous factors influence the penetrance and expressivity of genetically determined diseases...
May 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28454189/assessment-of-the-authenticity-of-herbal-dietary-supplements-comparison-of-chemical-and-dna-barcoding-methods
#9
Rahul S Pawar, Sara M Handy, Raymond Cheng, Nicole Shyong, Erich Grundel
About 7 % of the U. S. population reports using botanical dietary supplements. Increased use of such supplements has led to discussions related to their authenticity and quality. Reports of adulteration with substandard materials or pharmaceuticals are of concern because such substitutions, whether inadvertent or deliberate, may reduce the efficacy of specific botanicals or lead to adverse events. Methods for verifying the identity of botanicals include macroscopic and microscopic examinations, chemical analysis, and DNA-based methods including DNA barcoding...
April 28, 2017: Planta Medica
https://www.readbyqxmd.com/read/28454187/combination-of-transforaminal-and-interlaminar-percutaneous-endoscopic-lumbar-diskectomy-for-extensive-down-migrated-disk-herniation
#10
Kyung-Chul Choi, Jung Hyun Lee, Jin-Sung Kim, Dong Chan Lee, Choon Keun Park
Background and Study Aims The technique and instrumentation of percutaneous endoscopic lumbar diskectomy (PELD) have significantly improved. Thus its indications have been gradually expanding. Down-migrated disk, in particular, is regarded inaccessible by rigid instrumentation due to poor visualization and limited accessibility. We introduce a combination of transforaminal and interlaminar PELD for extensive down-migrated disk herniation at the L4-L5 level. Patients and Methods In the first case, a 48-year-old man had left L5 radicular pain...
April 28, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28454184/-register-of-difficult-surgical-situations
#11
Michael Korenkov, Henning Dralle, Ernst Klar, Stefan Saad, Norbert Senninger, Jens Standop, Albrecht Stier, Martin Strik, Alexis Ulrich, Rudolf Weiner
Every surgical problem that increases the likelihood of intraoperative and postoperative complications is considered to be a difficult surgical situation. Based on this definition, Korenkov et al. proposed to classify patients according to the following intraoperative difficulty levels (I to IV): (I) ideal situation (easy to operate, no problems), (II) fairly easy/manageable/simple (some minor difficulties may occur), (III) difficult/problematic (difficult to operate; some operative techniques are considerably more difficult than others), and (IV) very difficult (every operative step is difficult/challenging)...
April 28, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28454177/thulium-fiber-pumped-tunable-ho-caf-sub-2-sub-laser
#12
Michal Němec, Jan Šulc, Michal Jelínek, Václav Kubeček, Helena Jelínková, Maxim E Doroshenko, Olimkhon K Alimov, Vasilii A Konyushkin, Andrei N Nakladov, Vyatcheslav V Osiko
The paper reports the first room-temperature operation of the in-band pumped Ho:CaF<sub>2</sub> laser. A set of Ho:CaF<sub>2</sub> crystals varying in holmium concentrations (from 0.1 up to 2.5 mol. % of HoF<sub>2</sub>), synthesized using the Bridgeman technique, was used for lasing and related spectroscopy investigation. A pulsed 1.94 μm thulium fiber laser system was used for Ho:CaF<sub>2</sub> longitudinal pumping. For 1.5 mol. % of Ho:CaF<sub>2</sub>, the maximal wavelength tunability (from 2073 to 2114 nm) and output energy (1...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454176/phaseless-incoherent-optical-frequency-domain-spectroscopy
#13
Ziv Glasser, Gidon Zaychik, Rita Abramov, Daniel Gotliv, Shmuel Sternklar
We describe a new technique for incoherent optical frequency domain spectroscopy (I-OFDS) that does not require measurements of the RF phase spectrum in order to reconstruct the optical spectrum. It is based on the addition of either an optical or electronic reference line to the I-OFDS system. Compared to the spectrum acquired by a regular I-OFDS system, high accuracy (error<1%) is predicted and achieved.
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454175/estimation-of-photonic-crystal-fiber-dispersion-by-means-of-supercontinuum-generation
#14
Julius Vengelis, Vygandas Jarutis, Valdas Sirutkaitis
We present a technique for photonic crystal fiber dispersion measurement. We demonstrate that investigating supercontinuum using cross-correlation frequency resolved optical gating (XFROG) technique can be used for quantitatively characterizing dispersion and observing orthogonal polarization modes in polarization maintaining photonic crystal fibers. In addition, an XFROG trace of supercontinuum generated in a polarization maintaining photonic crystal fiber reveals complex behavior of orthogonal polarization modes that is different in normal and anomalous dispersion regions of the photonic crystal fiber...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454173/on-the-cancellation-of-oam-beams-propagating-through-convective-turbulence
#15
Gustavo Funes, Jaime Anguita
By means of an experimental setup, we study the time evolution of orbital angular momentum (OAM) crosstalk after a 5 m propagation path with a turbulence perturbation generated by a flat heater. This convective turbulence could simulate the beam passing over hot concrete or building roofs. We study the consequences of using a wide range of transmission OAM states. We also explore the effect of misalignment, and we propose two new different techniques for analyzing the vortex cancellation. Even though results are inconsistent with theoretical predictions, especially for low turbulence regimes, we state that signal-to-noise ratio is the key factor to understanding this discrepancy...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454172/are-optical-fibers-really-uniform-measurement-of-refractive-index-on-a-centimeter-scale
#16
Sébastien Loranger, Raman Kashyap
Many applications of optical fiber, such as specialized fiber Bragg gratings (FBGs), require high uniformity of a fiber's refractive index (RI) along its length. We show here that the mode effective index of most fibers is not constant, even on a short length scale. To help improve fiber manufacturing and selection, we demonstrate a technique for characterizing a meter length single-mode optical fiber's effective RI over a centimeter scale with a precision of 3×10<sup>-6</sup> RI units (RIUs) and an absolute accuracy of 2×10<sup>-4</sup> RIU...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454163/image-recovery-from-defocused-2d-fluorescent-images-in-multimodal-digital-holographic-microscopy
#17
Xiangyu Quan, Osamu Matoba, Yasuhiro Awatsuji
A technique of three-dimensional (3D) intensity retrieval from defocused, two-dimensional (2D) fluorescent images in the multimodal digital holographic microscopy (DHM) is proposed. In the multimodal DHM, 3D phase and 2D fluorescence distributions are obtained simultaneously by an integrated system of an off-axis DHM and a conventional epifluorescence microscopy, respectively. This gives us more information of the target; however, defocused fluorescent images are observed due to the short depth of field. In this Letter, we propose a method to recover the defocused images based on the phase compensation and backpropagation from the defocused plane to the focused plane using the distance information that is obtained from a 3D phase distribution...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454161/correlation-and-squeezing-for-optical-transistor-and-intensity-router-applications-in-diamond-nv-center
#18
Noor Ahmed, Ghulam Abbas Khan, Ruimin Wang, Jingru Hou, Rui Gong, Lingmeng Yang, Yanpeng Zhang
We study an optical transistor (switch and amplifier) and router by spontaneous parametric four-wave mixing and fluorescence in diamond nitrogen-vacancy (NV) center. The routing results from three peaks of fluorescence signal in the time domain, while the switching and amplification are realized by correlation and squeezing. The intensity switching speed is about 17 ns. The optical transistor and router are controlled by the power of incident beams. Our experimental results provide that the advance technique of peak division and channel equalization ratio of about 90% are applicable to all optical switching and routing...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454146/snr-enhancement-in-high-resolution-phase-sensitive-otdr-systems-using-chirped-pulse-amplification-concepts
#19
Juan Pastor-Graells, Luis Romero Cortés, María R Fernández-Ruiz, Hugo F Martins, José Azaña, Sonia Martin-Lopez, Miguel Gonzalez-Herraez
Phase-sensitive optical time-domain reflectometry (φOTDR) is widely used for the distributed detection of mechanical or environmental variations with resolutions of typically a few meters. The spatial resolution of these distributed sensors is related to the temporal width of the input probe pulses. However, the input pulse width cannot be arbitrarily reduced (to improve the resolution), since a minimum pulse energy is required to achieve a good level of signal-to-noise ratio (SNR), and the pulse peak power is limited by the advent of nonlinear effects...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454144/automatic-focusing-for-multisectional-objects-in-digital-holography-using-the-structure-tensor
#20
Zhenbo Ren, Ni Chen, Edmund Y Lam
Determining the axial position of the recorded object in digital holography is a crucial step for image reconstruction. When multiple discrete sections of a three-dimensional object are overlapping each other, this issue becomes more challenging. In this Letter, an autofocusing algorithm using the structure tensor and its eigenvalues is proposed. This method can extract the focal distance of each section for a multi-sectional object irrespective of whether the sections are overlapping or not. We validate the applicability of the proposed technique with synthesized and experimental data using two types of holographic systems...
May 1, 2017: Optics Letters
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