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Anti-NMDA Encephalitis

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https://www.readbyqxmd.com/read/29876905/-autoimmune-encephalitis
#1
M Guasp, H Arino, J Dalmau
Autoimmune encephalitis are a new category of inflammatory diseases of the central nervous system mediated by antibodies that attack neurotransmitter or protein receptors on the surface of neurons. The clinical syndromes are complex and are associated with manifestations that vary according to the type of antibody that is associated. The autoimmune response can start due to the presence of a tumour or viral infection, but in many case the cause remains unknown. In paediatrics, the most frequent autoimmune encephalitis is that associated with NMDA glutamate receptor antibodies (or anti-NMDA encephalitis)...
June 5, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29807927/teaching-neuroimages-prosopagnosia-heralding-anti-nmda-receptor-encephalitis
#2
Grayson Beecher, Amanda Nicole Wagner, Jonathan Abele, Penelope Smyth
No abstract text is available yet for this article.
May 29, 2018: Neurology
https://www.readbyqxmd.com/read/29801900/practical-issues-in-measuring-autoantibodies-to-neuronal-cell-surface-antigens-in-autoimmune-neurological-disorders-190-cases
#3
Juntaro Kaneko, Naomi Kanazawa, Naomi Tominaga, Atsushi Kaneko, Hiroki Suga, Ryo Usui, Daisuke Ishima, Eiji Kitamura, Tsugio Akutsu, Koji Yoshida, Kazutoshi Nishiyama, Takahiro Iizuka
OBJECTIVES: To address practical issues in measuring autoantibodies to neuronal cell-surface antigens (NSAs) in various autoimmune neurological disorders (ANDs). METHODS: We retrospectively reviewed the clinical information of 221 patients with clinically suspected ANDs who underwent antibody testing for NSAs between January 2007 and September 2017. 31 were excluded. In 190 patients, antibody-detection rate (ADR) and antibody-phenotype association were assessed...
July 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29785583/the-effect-of-delayed-anti-nmdar-encephalitis-recognition-on-disease-outcome
#4
Vlatko Sulentic, Zeljka Petelin Gadze, Filip Derke, Marija Santini, Danira Bazadona, Sibila Nankovic
Anti-NMDA receptor encephalitis is an acute form of brain inflammation that is potentially lethal but has a high probability for recovery with treatment. Although the clinical picture of anti-NMDAR encephalitis is usually recognizable due to its relatively well-known symptoms, the disorder can sometimes present itself in an unpredictable and atypical way. In this case report, we wish to present the influence of different delay times prior to the establishment of diagnosis. Thus, our first patient was diagnosed with anti-NMDAR encephalitis 4 years after the initial symptoms, the second one after 8 years, and the third one after 13 months...
May 21, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29761122/bortezomib-treatment-for-severe-refractory-anti-nmda-receptor-encephalitis
#5
Yong-Won Shin, Soon-Tae Lee, Tae-Joon Kim, Jin-Sun Jun, Kon Chu
Objective: To evaluate the therapeutic potential of bortezomib, a proteasome inhibitor that target plasma cells, in order to revive stalled recovery in patients with anti- N -methyl-d-aspartate (NMDA) receptor encephalitis who remain bedridden even after aggressive immunotherapy. Methods: We consecutively enrolled patients with anti-NMDA receptor encephalitis who remained bedridden after first-line immunotherapy (steroids and intravenous immunoglobulin), second-line immunotherapy (rituximab), and tocilizumab treatment, and treated them with subcutaneous bortezomib...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29759996/pearls-oy-sters-relapse-of-anti-nmda-receptor-encephalitis-after-prior-first-and-second-line-immunotherapy
#6
Sharon Chiang, Tanu Garg, Austin Hu, Hitha Amin, Alfredo Davalos-Balderas, Isabel Alfradique-Dunham, Corey E Goldsmith
No abstract text is available yet for this article.
May 15, 2018: Neurology
https://www.readbyqxmd.com/read/29742610/18f-fdg-pet-ct-in-anti-nmda-receptor-encephalitis-typical-pattern-and-follow-up
#7
Abdenasser Moubtakir, Sébastien Dejust, François Godard, Leila Messaoud, David Morland
We report the case of a 28-year-old woman presenting behavior disorders of subacute onset. She was referred in our institution for a suspicion of limbic encephalitis. F-FDG PET/CT did not show any mesiotemporal abnormality but depicted a decreased uptake of bilateral parietal and occipital lobes. This atypical pattern was compatible with an anti-N-methyl-D-aspartate receptor encephalitis that was later confirmed.
July 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29739177/anesthesia-management-in-a-case-of-turner-syndrome-with-anti-nmda-limbic-encephalitis-and-multiple-co-morbidities-for-repair-of-fracture-femur
#8
Bhavna Gupta, Munisha Agarwal, Rohan Sharma, Vandana Saith
No abstract text is available yet for this article.
May 9, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29738958/predictive-values-and-specificity-of-electroencephalographic-findings-in-autoimmune-encephalitis-diagnosis
#9
Chusak Limotai, Chayaporn Denlertchaikul, Abhinbhen W Saraya, Suda Jirasakuldej
OBJECTIVE: Early diagnosis of autoimmune encephalitis (AE) to not delay treatment is challenging but needed in practice. Most previous evidences of electroencephalographic (EEG) findings in AE were derived from descriptive studies. Given paucity of evidence of specific EEG findings to help with early diagnosis of AE, this study aimed to ascertain specific EEG findings and assess their predictive values in diagnosis of AE. METHODS: We included all cases with AE in our institution from January 2013 to June 2017...
July 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29724875/unusual-case-of-anti-n-methyl-d-aspartic-acid-receptor-nmda-r-encephalitis-and-autoimmune-polyglandular-syndrome-aps
#10
Simona Frunza-Stefan, Hilary B Whitlatch, Gautam G Rao, Rana Malek
Anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis is a novel disease discovered within the past 10 years. It is an autoimmune disease (AD) that has been associated with other ADs, such as Graves' disease. However, association with autoimmune polyglandular syndromes (APS) has not been previously described. A 58-year-old woman presented with altered mental status and an 8-month history of weight loss, apathy and somnolence. Laboratory evaluation confirmed Graves' disease with thyrotoxicosis and type 1 diabetes mellitus...
May 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29629396/anti-nmda-receptor-encephalitis-and-nonencephalitic-hsv-1-infection
#11
Amy Salovin, Jason Glanzman, Kylie Roslin, Thais Armangue, David R Lynch, Jessica A Panzer
Objective: To determine whether there is an association between nonencephalitic herpes simplex virus 1 (HSV-1) infection and anti-NMDA receptor encephalitis (anti-NMDARE). Methods: Antibody testing was performed using samples from 2 cohorts in a case-control observational study. The cohort "Philadelphia" included 16 serum samples of pediatric anti-NMDARE cases and 42 age-matched controls with other neuroinflammatory disorders studied at the Children's Hospital of Philadelphia and University of Pennsylvania...
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29628174/early-identification-of-anti-nmda-receptor-encephalitis-presenting-cerebral-lesions-in-unconventional-locations-on-magnetic-resonance-imaging
#12
Weihe Zhang, Lei Cui, Wei Wang, Yujuan Jiao, Yeqiong Zhang, Jinsong Jiao
To facilitate the diagnosis of anti-NMDAR encephalitis presenting with brain lesions in unconventional locations (BLUL) on MRI, we retrospectively analyzed forty-five Chinese patients. Eighteen (40.0%) of their MRI initially exhibited one or more BLUL. These locations predominantly included cerebral gray matter (cortex, basal ganglia and thalamus), as well as white matter and brainstem. Due to these BLUL, thirteen (72.2%) patients were originally misdiagnosed with other diseases and developed poor clinical and imaging outcomes...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29617708/a-systematic-review-of-the-neuropsychological-sequelae-of-people-diagnosed-with-anti-n-methyl-d-aspartate-receptor-encephalitis-in-the-acute-and-chronic-phases
#13
Della C M Nicolle, Jennifer L Moses
Objective: A systematic review was conducted to investigate the emerging cognitive profile for people diagnosed with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. Method: Ten papers met the review criteria including five neuropsychological case studies and five case series; three of the 10 studies used matched controls. The cognitive functioning of 54 participants (46 female: eight male) was studied. Paper quality assessment was undertaken and outcomes summarized...
March 31, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29607915/-a-case-of-limbic-encephalitis-associated-with-sj%C3%A3-gren-s-syndrome-mimicking-anti-n-methyl-d-aspartate-receptor-encephalitis
#14
Kenji Yoshimura, Rie Kanki, Satoshi Nakano
A 25-year-old woman in her 37 weeks and 5 days pregnant presented with abnormal behavior and memory impairment following a high fever. Her manifestations were diagnosed as limbic encephalitis, and she delivered a baby by Cesarean section. In the operation, bilateral ovarian tumors were found and resected, though they were revealed as non-teratoma afterward. After operation, she became agitated, and started to present oral dyskinesia, intractable systemic myoclonus, central hypoventilation, and autonomic manifestations such as labile blood pressure, but her symptoms responded well to immunotherapy...
April 25, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29605275/magnetic-resonance-imaging-and-positron-emission-tomography-in-anti-nmda-receptor-encephalitis-a-systematic-review
#15
Stephen Bacchi, Kyle Franke, Dasith Wewegama, Edward Needham, Sandy Patel, David Menon
Due to a variety of clinical manifestations anti-N-methyl-d-aspartate (NMDA) receptor encephalitis may be difficult to diagnose. Magnetic resonance imaging (MRI) may be used as a component of the workup for encephalopathy. However, the use of MRI in anti-NMDA encephalitis is complicated by wide-ranging reports regarding the frequency of normal MRI findings in this disease. Positron emission tomography (PET) is a modality of imaging that may assess functional rather than structural disturbances. Therefore, this review was conducted to summarise published studies regarding the use of MRI and PET in the diagnosis of anti-NMDA receptor encephalitis...
June 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29580710/extreme-delta-with-or-without-brushes-a-potential-surrogate-marker-of-disease-activity-in-anti-nmda-receptor-encephalitis
#16
Claude Steriade, Stephen Hantus, Ahsan N V Moosa, Alexander D Rae-Grant
OBJECTIVE: Anti-NMDA receptor encephalitis (NMDARE) may not respond to first line immunotherapy. Biomarkers to track disease course and guide escalation of immunotherapy are needed. We describe the evolution of EEG in four patients with NMDARE requiring prolonged intensive care. METHODS: Within a database of 121 patients with immune-mediated neurological disorders, ten with NMDARE were retrospectively identified. Four patients did not respond to first line immunotherapy...
March 10, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29572931/genetic-predisposition-in-anti-lgi1-and-anti-nmda-receptor-encephalitis
#17
Stefanie H Mueller, Anna Färber, Harald Prüss, Nico Melzer, Kristin S Golombeck, Tania Kümpfel, Franziska Thaler, Martin Elisak, Jan Lewerenz, Max Kaufmann, Kurt-Wolfram Sühs, Marius Ringelstein, Christoph Kellinghaus, Christian G Bien, Andrea Kraft, Uwe K Zettl, Sven Ehrlich, Robert Handreka, Kevin Rostásy, Florian Then Bergh, Jürgen H Faiss, Wolfgang Lieb, Andre Franke, Gregor Kuhlenbäumer, Klaus-Peter Wandinger, Frank Leypoldt
We performed a genome-wide association study in 1,194 controls and 150 patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR, n = 96) or anti-leucine-rich glioma-inactivated1 (anti-LGI1, n = 54) autoimmune encephalitis. Anti-LGI1 encephalitis was highly associated with 27 single-nucleotide polymorphisms (SNPs) in the HLA-II region (leading SNP rs2858870 p = 1.22 × 10-17 , OR = 13.66 [7.50-24.87]). Potential associations, below genome-wide significance, were found with rs72961463 close to the doublecortin-like kinase 2 gene (DCLK2) and rs62110161 in a cluster of zinc-finger genes...
April 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29549218/clinical-and-pathogenic-significance-of-igg-iga-and-igm-antibodies-against-the-nmda-receptor
#18
Makoto Hara, Eugenia Martinez-Hernandez, Helena Ariño, Thais Armangué, Marianna Spatola, Mar Petit-Pedrol, Albert Saiz, Myrna R Rosenfeld, Francesc Graus, Josep Dalmau
OBJECTIVE: To determine the frequency and clinical relevance of immunoglobulin (Ig)G, IgA, and IgM N -methyl-d-aspartate receptor (NMDAR) antibodies in several diseases, and whether the IgG antibodies occur in disorders other than anti-NMDAR encephalitis. METHODS: Evaluation of IgG, IgA, and IgM NMDAR antibodies in serum of 300 patients with anti-NMDAR encephalitis, stroke, dementia, schizophrenia, or seronegative autoimmune encephalitis. Antibodies and their effect on cultured neurons were examined with cell-based assays and brain and live neuronal immunostaining...
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29535092/ovarian-teratoma-associated-with-anti-nmda-n-methyl-d-aspartate-receptor-encephalitis
#19
Nellihela Leel, Hemanshoo S Thakkar, David Drake, Nordeen Bouhadiba
Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a paraneoplastic, immune-mediated encephalopathy with a known association with ovarian teratomas. We present the first case in the UK of a 7-year-old patient presenting with this condition. Having been previously fit and healthy, the patient presented with an acute onset of cognitive disturbances. The initial suspicion was that of an infective encephalopathy; however, the lumbar puncture results were negative. Electroencephalography reported diffuse background slowing, supporting a diagnosis of encephalopathy...
March 13, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29515425/dystonic-seizures-and-intense-hyperperfusion-of-the-basal-ganglia-in-a-patient-with-anti-n-methyl-d-aspartate-receptor-encephalitis
#20
Hideyuki Matsumoto, Hideji Hashida, Yukitoshi Takahashi
This report describes a rare case presenting with dystonic seizures due to anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. The patient was an 18-year-old woman with repeated right-dominant dystonic seizures even under sedation. Single-photon emission computed tomography (SPECT) showed intense hyperperfusion of the caudate nuclei, putamen, globus pallidus, thalamus, and insula on the left side, suggesting encephalitis. Antibodies against NMDA receptors were detected in the sera and cerebrospinal fluids...
September 2017: Case Reports in Neurology
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