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Acute cervical spinal cord injury

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https://www.readbyqxmd.com/read/28228335/alterations-in-cardiac-autonomic-control-in-spinal-cord-injury
#1
Fin Biering-Sørensen, Tor Biering-Sørensen, Nan Liu, Lasse Malmqvist, Jill Maria Wecht, Andrei Krassioukov
A spinal cord injury (SCI) interferes with the autonomic nervous system (ANS). The effect on the cardiovascular system will depend on the extent of damage to the spinal/central component of ANS. The cardiac changes are caused by loss of supraspinal sympathetic control and relatively increased parasympathetic cardiac control. Decreases in sympathetic activity result in heart rate and the arterial blood pressure changes, and may cause arrhythmias, in particular bradycardia, with the risk of cardiac arrest in those with cervical or high thoracic injuries...
February 15, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28223038/nanoconjugate-bound-adenosine-a1-receptor-antagonist-enhances-recovery-of-breathing-following-acute-cervical-spinal-cord-injury
#2
Zeljka Minic, Sharowyn Wilson, Fangchao Liu, Abdulghani Sankari, Guangzhao Mao, Harry Goshgarian
Respiratory complications in patients with spinal cord injury (SCI) are common and can have a negative impact on the quality of patients' lives. Previously, we found that intradiaphragmatic administration of the nanoconjugate-bound A1 adenosine receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) induced recovery of diaphragm function following SCI in rats. When administered immediately following the injury, recovery was observed as early as 3days following SCI and it persisted until the end of the study, 28days after the drug delivery...
February 18, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28220822/pulmonary-outcomes-following-specialized-respiratory-management-for-acute-cervical-spinal-cord-injury-a-retrospective-analysis
#3
E C Zakrasek, J L Nielson, J J Kosarchuk, J D Crew, A R Ferguson, S L McKenna
STUDY DESIGN: Retrospective analysis. OBJECTIVES: To identify multivariate interactions of respiratory function that are sensitive to spinal cord injury level and pharmacological treatment to promote strategies that increase successful liberation from mechanical ventilation. SETTING: United States regional spinal cord injury (SCI) treatment center. METHODS: Retrospective chart review of patients consecutively admitted to Santa Clara Valley Medical Center between May 2013 and December 2014 for ventilator weaning with C1-C5 American Spinal Injury Association Impairment Scale (AIS) A or B SCI, <3 months from injury and who had a tracheostomy in place...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28216400/mri-prognostication-factors-in-the-setting-of-cervical-spinal-cord-injury-secondary-to-trauma
#4
Rafael Martínez-Pérez, Santiago Cepeda, Igor Paredes, Jose F Alen, Alfonso Lagares
BACKGROUND: and Purpose: Several studies have looked for an association between radiological findings and neurological outcome after cervical trauma. In the current literature, there is a paucity of evidence proving the prognostic role of soft tissue damage or bony integrity. Our objective is to determine radiological findings related to neurological prognosis in patients after incomplete acute traumatic cervical spinal cord injury, regardless of initial neurological exam. MATERIAL AND METHODS: We retrospectively reviewed patients with acute traumatic cervical Spinal Cord Injury who had an MRI performed within the first 96 hours...
February 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28198660/prediction-of-functional-recovery-six-months-following-traumatic-spinal-cord-injury-during-acute-care-hospitalization
#5
Andréane Richard-Denis, Debbie Feldman, Cynthia Thompson, Jean-Marc Mac-Thiong
OBJECTIVES: To determine factors associated with functional status six months following a traumatic cervical and thoracic spinal cord injury (SCI), with a particular interest in factors related to the acute care hospitalization stay. DESIGN: This is a prospective cohort study. Sixteen potential predictive variables were studied. Univariate regression analyses were first performed to determine the strength of association of each variable independently with the total Spinal Cord Independence Measure (SCIM) score...
February 15, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28187803/management-of-acute-traumatic-spinal-cord-injuries
#6
C D Shank, B C Walters, M N Hadley
Acute traumatic spinal cord injury (SCI) is a devastating disease process affecting tens of thousands of people across the USA each year. Despite the increase in primary prevention measures, such as educational programs, motor vehicle speed limits, automobile running lights, and safety technology that includes automobile passive restraint systems and airbags, SCIs continue to carry substantial permanent morbidity and mortality. Medical measures implemented following the initial injury are designed to limit secondary insult to the spinal cord and to stabilize the spinal column in an attempt to decrease devastating sequelae...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28175418/168%C3%A2-impact-of-initial-clinical-and-imaging-parameters-on-long-term-neurological-outcomes-in-acute-traumatic-cervical-spinal-cord-injury
#7
Sunil Kukreja, Jan Schwab, Francis Farhadi
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28132610/upper-limb-recovery-in-spinal-cord-injury
#8
Jens A Petersen, Martina Spiess, Armin Curt, Norbert Weidner, Rüdiger Rupp, Rainer Abel, Martin Schubert
BACKGROUND AND OBJECTIVE: The course of central and peripheral motor recovery after cervical spinal cord injury (SCI) may be investigated by electrophysiological measures. The goal of this study was to compare the 2 over the first year after injury in relation to motor gains. METHODS: Compound motor action potentials (CMAPs), motor-evoked potentials (MEPs), and F-waves were recorded from the abductor digiti minimi and CMAP and F-waves from abductor hallucis muscles in 305 patients at about 15 days, 1 month, 3 months, 6 months, and 12 months following an acute traumatic SCI...
January 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28130472/long-term-functional-outcome-in-patients-with-acquired-infections-after-acute-spinal-cord-injury
#9
Marcel A Kopp, Ralf Watzlawick, Peter Martus, Vieri Failli, Felix W Finkenstaedt, Yuying Chen, Michael J DeVivo, Ulrich Dirnagl, Jan M Schwab
OBJECTIVE: To investigate whether prevalent hospital-acquired pneumonia and wound infection affect the clinical long-term outcome after acute traumatic spinal cord injury (SCI). METHODS: This was a longitudinal cohort study within the prospective multicenter National Spinal Cord Injury Database (Birmingham, Alabama). We screened datasets of 3,834 patients enrolled in 20 trial centers from 1995 to 2005 followed up until 2016. Eligibility criteria were cervical SCI and American Spinal Cord Injury Association impairment scale A, B, and C...
January 27, 2017: Neurology
https://www.readbyqxmd.com/read/28117330/successful-tracheostomy-decannulation-after-complete-or-sensory-incomplete-cervical-spinal-cord-injury
#10
D H Kim, S W Kang, W A Choi, H J Oh
STUDY DESIGN: Retrospective study. OBJECTIVES: To report the successful tracheostomy decannulation/extubation in cervical spinal cord injury (C-SCI) patients. SETTING: Tertiary university hospital, pulmonary rehabilitation center. METHODS: Complete or sensory incomplete C-SCI patients who had received invasive acute phase respiratory management, and succeeded in decannulation/extubation became candidates of this study...
January 24, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28114866/refractory-orthostatic-hypotension-in-a-patient-with-a-spinal-cord-injury-treatment-with-droxidopa
#11
Eva Canosa-Hermida, Cristina Mondelo-García, María Elena Ferreiro-Velasco, Sebastián Salvador-de la Barrera, Antonio Montoto-Marqués, Antonio Rodríguez-Sotillo, José Ramón Vizoso-Hermida
CONTEXT: Orthostatic hypotension (OH) is a common complication in patients with a spinal cord injury, mainly affecting complete injuries above neurological level T6. It is generally more severe during the acute phase but can remain symptomatic for several years. FINDINGS: A 65-year-old male with a grade ASIA A post-traumatic cervical spinal cord injury, at neurological level C4, presenting with symptomatic refractory OH. Increased blood pressure (BP) levels and an overall clinical improvement was observed after administering an increasing dose of droxidopa...
January 24, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28112598/acute-effects-of-glossopharyngeal-insufflation-in-people-with-cervical-spinal-cord-injury
#12
Malin Nygren-Bonnier, Tomas A Schiffer, Peter Lindholm
OBJECTIVES: To evaluate acute effects of glossopharyngeal insufflation (GI) on lung function, airway pressure (Paw), blood pressure and heart rate (HR) in people with cervical spinal cord injury (CSCI). DESIGN: Case-control design. SETTING: Karolinska Institutet, Stockholm, Sweden. PARTICIPANTS: Ten participants with CSCI suffering from lesions between C4 and C8, and ASIA classification of A or B were recruited. Ten healthy particpants familiar with GI were recruited as a reference group...
January 23, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28111622/cruciate-paralysis-in-a-20-year-old-male-with-an-undisplaced-type-iii-odontoid-fracture
#13
Mansukhani Sameer A, Tuteja Sanesh V, Dhar Sanjay B
INTRODUCTION: Cruciate Paralysis is a rare incomplete spinal cord syndrome presenting as brachial diplegia with minimal or no involvement of the lower extremities. It occurs as a result of trauma to the cervical spine and is associated with fractures of the axis and/or atlas. Diagnosis is confirmed on MRI and is managed by treatment of the underlying pathology. Prognosis depends on the extent of spinal cord injury and the exact cause. CASE PRESENTATION: A 20-year-old male presented to the casualty with a history of an injury to the back of the head as a result of a fall...
April 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28107239/management-of-pharyngeal-fistulas-after-anterior-cervical-spine-surgery-a-treatment-algorithm-for-severe-complications
#14
Christian Simon, Carl H Fürstenberg, Markus Eichler, Stefan Rohde, Cem Bulut, Bernd Wiedenhöfer
STUDY DESIGN: This study is a retrospective database query to identify all anterior spinal approaches. OBJECTIVES: The objectives were to assess all patients with pharyngocutaneous fistulas (PCFs) after anterior cervical spine surgery. SUMMARY OF BACKGROUND DATA: Patients with the diagnosis of PCFs were treated at the University of Heidelberg Spine Medical Center, Spinal Cord Injury Unit and Department of Otolaryngology (Germany), between 2005 and 2011...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28056284/-clinical-value-of-diffusion-tensor-imaging-parameter-value-in-evaluating-the-prognosis-of-spinal-cord-injury-in-acute-cervical-spinal-cord-injury
#15
Z M Zou, J Li, Q Y Cao, H X Lian, C N He, B Wang
Objective: To evaluate the clinical application value of diffusion tensor imaging (DTI) parameter in evaluating the prognosis of spinal cord injury in acute cervical spinal cord injury. Method: From October 2012 to December 2015, a total of 23 patients with acute cervical spinal cord injury were examined by routine MRI-T2WI high signal DTI examination, according to the American Spinal Injury Association (ASIA) damage standard. One month later according to the functional outcome of the spinal cord, all patients were divided into non improvement group (group A) 4 cases (2 cases of ASIA-A, 2 cases of grade B) and improvement group (group B) 19 cases (13 cases of ASIA-C, 5 cases of grade D, 1 case of grade B), 15 cases of healthy volunteers as the normal group (group C )...
January 3, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28053621/clinical-and-magnetic-resonance-imaging-features-of-compressive-cervical-myelopathy-with-traumatic-intervertebral-disc-herniation-in-cynomolgus-macaque-macaca-fascicularis
#16
Yun-Jung Choi, Hye-Jin Park, Chul-Ho Sohn, Kyeong Cheon Jung, Seong Hoe Park, Jae-Il Lee
Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering from acute and progressive neurological dysfunction by a blunt trauma due to neck collar, an animal handling device. Tetraplegia, urinary incontinence, decreased proprioception, and imperception of pain were shown on physical and neurological examinations. MRI sagittal T2 weighted sequences revealed an extensive protrusion of disc material between C2 and C3 cervical vertebra, and this protrusion resulted in central stenosis of the spinal cord...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28018284/developmental-changes-in-pain-and-spinal-immune-gene-expression-after-radicular-trauma-in-the-rat
#17
Gordon A Barr, Shaoning Wang, Christine L Weisshaar, Beth A Winkelstein
Neuropathic pain is chronic pain that develops after nerve injury and is less frequent in infants and children than in adults. Likewise, in animal models of neuropathic pain, allodynia and hyperalgesia are non-existent or attenuated in the infant, with a "switch" during development by which acute nerve injury transitions to chronic pain. Concomitant with the delay in neuropathic pain, there is a parallel delay in the ability of nerve injury to activate the immune system. Models of neuropathic pain in the infant have used various ligation methods and find that neuropathic pain does not occur under after postnatal days 21-28 (PN21-PN28), linked to activation of immune processes and developmental regulation of anti-inflammatory cytokines...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/28007771/multivariate-analysis-of-mri-biomarkers-for-predicting-neurologic-impairment-in-cervical-spinal-cord-injury
#18
J Haefeli, M C Mabray, W D Whetstone, S S Dhall, J Z Pan, P Upadhyayula, G T Manley, J C Bresnahan, M S Beattie, A R Ferguson, J F Talbott
BACKGROUND AND PURPOSE: Acute markers of spinal cord injury are essential for both diagnostic and prognostic purposes. The goal of this study was to assess the relationship between early MR imaging biomarkers after acute cervical spinal cord injury and to evaluate their predictive validity of neurologic impairment. MATERIALS AND METHODS: We performed a retrospective cohort study of 95 patients with acute spinal cord injury and preoperative MR imaging within 24 hours of injury...
December 22, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27995938/a-radiographic-evaluation-of-facet-sagittal-angle-in-cervical-spinal-cord-injury-without-major-fracture-or-dislocation
#19
T Takao, K Kubota, T Maeda, S Okada, Y Morishita, E Mori, I Yugue, O Kawano, H Sakai, T Ueta, K Shiba
STUDY DESIGN: A retrospective radiographic study with a minimum 2-year follow-up. OBJECTIVE: To evaluate the relationships between the cervical articular facets' morphology and the incidence of traumatic cervical spinal cord injury (CSCI) without major fracture or dislocation. SETTING: Spinal Injuries Center, Japan. METHODS: This study included 113 patients with traumatic CSCI without major fracture or dislocation. Eighty-four healthy volunteers without neurological deficits or cervical cord pathology on magnetic resonance imaging (MRI) were defined as control subjects...
December 20, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27933357/bilateral-increases-in-erk-activation-at-the-spinomedullary-junction-region-by-acute-masseter-muscle-injury-during-temporomandibular-joint-inflammation-in-the-rats
#20
Masayuki Kurose, Hiroki Imbe, Yosuke Nakatani, Mana Hasegawa, Noritaka Fujii, Ritsuo Takagi, Kensuke Yamamura, Emiko Senba, Keiichiro Okamoto
We determined the role of persistent monoarthritis of temporomandibular joint region (TMJ) on bilateral masseter muscle (MM) nociception in male rats using orofacial nocifensive behaviors, phosphorylated extracellular signal-regulated kinase and Fos induction at the trigeminal subnucleus caudalis/upper cervical spinal cord (Vc/C2) region in response to formalin injection to the MM region. TMJ inflammation was induced by local injection of CFA into the left TMJ region. Orofacial nocifensive behaviors evoked by formalin injection ipsilateral or contralateral to the TMJ inflammation appeared to be increased at 1-14 days or at 1, 10 and 14 days after induction of TMJ inflammation, respectively, while increases in behavioral duration were seen mainly in the late phase rather than the early phase...
December 8, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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