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Mifepristone

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https://www.readbyqxmd.com/read/29040004/building-bridges-a-case-for-community-health-worker-provision-of-misoprostol-only-abortion-in-the-first-trimester
#1
Claire Tebbets, Diana Santana, José Ros Silvestre, Dee Redwine
INTRODUCTION: The consequences of unsafe abortion are devastating to women, their families, and their communities. Medication abortion presents an important alternative to harmful self-induction practices and surgical intervention under questionable circumstances. In settings where mifepristone is unavailable, the use of misoprostol alone is a safe and effective option for terminating an unwanted pregnancy. Studies have demonstrated the safety and efficacy of administration of misoprostol by community health workers (CHW) for indications such as postpartum hemorrhage and treatment of incomplete abortion...
October 17, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29038033/cervical-preparation-prior-to-surgical-abortion-in-real-life-conditions-and-factors-driving-the-prescription-a-national-observational-study
#2
Philippe David, Virginie Rondeau, Mathilde Pouriel, Aubert Agostini
INTRODUCTION: Few data exist to document the real-life practices regarding surgical abortion for first trimester abortion, in particular regarding the cervical preparation. Using a large national sample of French hospitals practicing surgical abortion, we explore actual practices and described drugs used for cervical preparation and factors that influence the prescription. METHODS: From December 2013 to July 2014, a longitudinal, prospective, multicenter, non-interventional study was undertaken with the main objective of assessing in real-life conditions the modalities of cervical preparation prior surgical abortion in women with less than 14 weeks of amenorrhea...
October 13, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/29030227/exploring-the-feasibility-of-obtaining-mifepristone-and-misoprostol-from-the-internet
#3
Chloe Murtagh, Elisa Wells, Elizabeth G Raymond, Francine Coeytaux, Beverly Winikoff
OBJECTIVES: We aimed to document the experience of buying abortion pills from online vendors that do not require a prescription and to evaluate the active ingredient content of the pills received. STUDY DESIGN: We searched the internet to identify a convenience sample of websites that sold mifepristone and misoprostol to purchasers in the United States and attempted to order these products. We documented price, shipping time and other aspects of ordering. We sent the samples received to a testing laboratory that measured the amount of active ingredient in individual tablets...
October 10, 2017: Contraception
https://www.readbyqxmd.com/read/29023594/first-trimester-medication-abortion-practice-in-the-united-states-and-canada
#4
Heidi E Jones, Katharine O'Connell White, Wendy V Norman, Edith Guilbert, E Steve Lichtenberg, Maureen Paul
We conducted a cross-sectional survey of abortion facilities from professional networks in the United States (US, n = 703) and Canada (n = 94) to estimate the prevalence of medication abortion practices in these settings and to look at regional differences. Administrators responded to questions on gestational limits, while up to five clinicians per facility reported on 2012 medication abortion practice. At the time of fielding, mifepristone was not approved in Canada. 383 (54.5%) US and 78 (83.0%) Canadian facilities participated...
2017: PloS One
https://www.readbyqxmd.com/read/29022184/effects-of-ketoconazole-on-the-pharmacokinetics-of-mifepristone-a-competitive-glucocorticoid-receptor-antagonist-in-healthy-men
#5
Dat Nguyen, Sarah Mizne
INTRODUCTION: Mifepristone, a competitive glucocorticoid receptor antagonist approved for Cushing syndrome, and ketoconazole, an antifungal and steroidogenesis inhibitor, are both inhibitors of and substrates for cytochrome P450 (CYP3A4). This study evaluated the pharmacokinetic effects of concomitant ketoconazole, a strong CYP3A4 inhibitor, on mifepristone. METHODS: In an open-label, two-period, single-center study, healthy adult men received mifepristone 600 mg orally daily for 12 days (period 1) followed by mifepristone 600 mg daily plus ketoconazole 200 mg orally twice daily for 5 days (period 2)...
October 11, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29020779/management-of-medical-termination-of-pregnancy-mtop-up-until-the-7th-week-of-gestation-in-the-czech-republic
#6
P Slunska, J Hanacek, M Fanta, B Sehnal, R Gerychová, A Hola, A Zdenkova, H Neumannová, M Dziakova, M Lubusky
OBJECTIVE: In the Czech Republic (CR), it is possible, to carry out Medical Termination of Pregnancy (MToP) in the 1st trimester since June 2014, in case a woman submits a written request for it and in case the ultrasound examination confirms an intrauterine singleton prosperous pregnancy, between day 42 and 49 of gestation, crown-rump length (CRL) of the embryo 2-9 mm. The aim of the study is to analyze the management of MToP up until the 7th week of gestation in five centres in the CR...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29020778/-management-of-medical-termination-of-pregnancy-mtop-up-until-the-7th-week-of-gestation-in-the-czech-republic
#7
P Slunska, J Hanacek, M Fanta, B Sehnal, R Gerychová, A Hola, A Zdenkova, H Neumannová, M Dziakova, M Lubusky
OBJECTIVE: In the Czech Republic (CR), it is possible, to carry out Medical Termination of Pregnancy (MToP) in the 1st trimester since June 2014, in case a woman submits a written request for it and in case the ultrasound examination confirms an intrauterine singleton prosperous pregnancy, between day 42 and 49 of gestation, crown-rump length (CRL) of the embryo 2-9 mm. The aim of the study is to analyze the management of MToP up until the 7th week of gestation in five centres in the CR...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28993021/regulation-of-zebrafish-danio-rerio-locomotor-behavior-and-circadian-rhythm-network-by-environmental-steroid-hormones
#8
Yanbin Zhao, Kun Zhang, Karl Fent
Environmental exposure of fish to steroid hormones through wastewater and agricultural runoff may pose a health risk. Thus far, ecotoxicological studies have largely been focused on the disruption of the sex hormone system, but additional effects have been poorly investigated. Here we report on the effects of a series of different natural and synthetic steroid hormones on the locomotor behavior and the transcriptional levels of core clock genes in zebrafish eleuthero-embryos (Danio rerio). Of the 20 steroids analyzed, progestins and corticosteroids, including progesterone and cortisol, significantly decreased the locomotor activities of eleuthero-embryos at concentrations as low as 16 ng/L, while estrogens such as 17β-estradiol led to an increase...
October 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28988113/effects-of-dexamethasone-on-purinergic-signaling-in-murine-mast-cells-selective-suppression-of-p2x7-receptor-expression
#9
Kazuki Yoshida, Masaaki Ito, Yui Hoshino, Isao Matsuoka
Mast cells express many different purinergic receptors, including ionotropic P2X4 and P2X7, which recognize the accumulation of extracellular ATP released from activated and/or damaged cells. This results in the stimulation of mast cell functions. In this study, we investigated the effects of dexamethasone (Dex), an anti-inflammatory glucocorticoid widely used for the treatment of allergic disease, on purinergic receptor expression in mouse bone marrow-derived mast cells (BMMCs). Treatment of BMMCs with Dex decreased P2X7 receptor mRNA levels in a time- and concentration-dependent manner without affecting the expression of other purinergic receptor subtypes...
October 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28975434/high-intensity-focused-ultrasound-hifu-treatment-for-uterine-fibroids-a-meta-analysis
#10
Yongshuo Ji, Kaimeng Hu, Yu Zhang, Lijun Gu, Junqiu Zhu, Linglin Zhu, Yanfei Zhu, Hong Zhao
PURPOSE: High-intensity focused ultrasound (HIFU) is a non-invasive uterine-preserving treatment alternative to hysterectomy for women with fibroids. METHODS: We performed this meta-analysis to evaluate the efficacy of HIFU in the treatment of women with symptomatic fibroids comparing it to other approaches including medical treatment with mifepristone (Mife), traditional surgery with myomectomy or hysterectomy (MYC/HRM), and radiofrequency ablation (RF). 16 studies with 1725 women were included...
October 3, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28945761/early-life-stress-induced-alterations-in-rat-brain-structures-measured-with-high-resolution-mri
#11
R Angela Sarabdjitsingh, Manila Loi, Marian Joëls, Rick M Dijkhuizen, Annette van der Toorn
Adverse experiences early in life impair cognitive function both in rodents and humans. In humans this increases the vulnerability to develop mental illnesses while in the rodent brain early life stress (ELS) abnormalities are associated with changes in synaptic plasticity, excitability and microstructure. Detailed information on the effects of ELS on rodent brain structural integrity at large and connectivity within the brain is currently lacking; this information is highly relevant for understanding the mechanism by which early life stress predisposes to mental illnesses...
2017: PloS One
https://www.readbyqxmd.com/read/28943275/mifepristone-enhances-insulin-stimulated-akt-phosphorylation-and-glucose-uptake-in-skeletal-muscle-cells
#12
Izela Bernal-Sore, Mario Navarro-Marquez, César Osorio-Fuentealba, Francisco Díaz-Castro, Andrea Del Campo, Camila Donoso-Barraza, Omar Porras, Sergio Lavandero, Rodrigo Troncoso
Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic treatment-induced obesity. However, the mechanisms through which Mifepristone produces its beneficial effects are not completely elucidated. PURPOSE: To determine the effects of mifepristone on insulin-stimulated glucose uptake on a model of L6 rat-derived skeletal muscle cells...
September 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28941978/barriers-to-accessing-abortion-services-and-perspectives-on-using-mifepristone-and-misoprostol-at-home-in-great-britain
#13
Abigail R A Aiken, Katherine A Guthrie, Marlies Schellekens, James Trussell, Rebecca Gomperts
OBJECTIVE: To examine reasons for seeking abortion services outside the formal healthcare system in Great Britain, where abortion is legally available. STUDY DESIGN: We conducted a mixed-methods study among women resident in England, Scotland, and Wales who requested at-home medication abortion through online telemedicine initiative Women on Web (WoW) between November 22nd 2016 and March 22nd 2017. We examined the demographics and circumstances of all women requesting early medication abortion and conducted a content analysis of a sample of their anonymized emails to the service to explore their reasons for seeking help...
September 18, 2017: Contraception
https://www.readbyqxmd.com/read/28938623/mifepristone-inhibits-ovarian-cancer-metastasis-by-intervening-in-sdf-1-cxcr4-chemokine-axis
#14
Ning Zheng, Jiahang Chen, Weiqun Liu, Jian Liu, Tao Li, Hongning Chen, Jichuang Wang, Lee Jia
SDF-1/CXCR4 signaling axis determines the proliferative potential and site-specific cancer metastasis. Recent studies suggest involvement of the axis and steroidal hormone in ovarian cancer metastasis. Here we hypothesize that mifepristone (RU486), a well-known progesterone-based abortifacient, might interfere this axis and inhibit ovarian cancer metastasis. Mifepristone at concentrations < IC50 inhibited expression of CXCR4 on cell surface of ovarian cancer SKOV-3 and IGROV-1, and reduced expression of the intracellular CXCR4 protein and its related mRNA activated by SDF-1...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938459/selective-glucocorticoid-receptor-antagonist-cort125281-activates-brown-adipose-tissue-and-alters-lipid-distribution-in-male-mice
#15
Jan Kroon, Lisa L Koorneef, Jose K van den Heuvel, Cristy R C Verzijl, Nienke M van de Velde, Isabel M Mol, Hetty C M Sips, Hazel Hunt, Patrick C N Rensen, Onno C Meijer
Glucocorticoids influence a wide range of metabolic processes in the human body and excessive glucocorticoid exposure is known to contribute to the development of metabolic disease. We evaluated the utility of the novel glucocorticoid receptor (GR) antagonist CORT125281 for its potential to overcome adiposity, glucose intolerance and dyslipidaemia, and compared this head-to-head with classic GR antagonist RU486 (mifepristone). We show that, while RU486 displays cross-reactivity to the progesterone and androgen receptor, CORT125281 selectively inhibits GR transcriptional activity...
September 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/28935220/efficacy-of-medical-abortion-prior-to-six-gestational-weeks-a-systematic-review
#16
Nathalie Kapp, Maureen K Baldwin, Maria Isabel Rodriguez
OBJECTIVE: To describe the efficacy of medical abortion using mifepristone and misoprostol for gestations less than 6weeks. STUDY DESIGN: We searched PubMed and Cochrane databases for articles in any language that examined the success of mifepristone and misoprostol abortion at gestational ages<42days. Data was independently abstracted by two authors, and graded for evidence quality. A pooled analysis of efficacy and a summary odds ratio of abortion failure of<42days gestation compared with gestational week 42-49days was performed for randomized trials as well as for prospective studies...
September 18, 2017: Contraception
https://www.readbyqxmd.com/read/28931736/the-influence-of-stress-hormones-and-aggression-on-cooperative-behaviour-in-subordinate-meerkats
#17
Ben Dantzer, Ines Braga Goncalves, Helen C Spence-Jones, Nigel C Bennett, Michael Heistermann, Andre Ganswindt, Constance Dubuc, David Gaynor, Marta B Manser, Tim H Clutton-Brock
In cooperative breeders, aggression from dominant breeders directed at subordinates may raise subordinate stress hormone (glucocorticoid) concentrations. This may benefit dominants by suppressing subordinate reproduction but it is uncertain whether aggression from dominants can elevate subordinate cooperative behaviour, or how resulting changes in subordinate glucocorticoid concentrations affect their cooperative behaviour. We show here that the effects of manipulating glucocorticoid concentrations in wild meerkats (Suricata suricatta) on cooperative behaviour varied between cooperative activities as well as between the sexes...
September 27, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28922193/update-on-second-trimester-medical-abortion
#18
Klaira Lerma, Kate A Shaw
PURPOSE OF REVIEW: To review recent literature on second trimester abortion with medical methods. RECENT FINDINGS: Across studies published in the recent past, it is apparent that women prefer shorter procedures and procedure times. Several randomized controlled trials have confirmed adding mifepristone to the second trimester medication abortion regimen results in shorter abortion intervals from first misoprostol administration to complete fetal expulsion. A study of simultaneous administration of mifepristone and misoprostol yielded shorter mean 'total' abortion times, presenting several logistical advantages...
September 15, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28901007/pharmacological-and-mechanical-interventions-for-labour-induction-in-outpatient-settings
#19
REVIEW
Joshua P Vogel, Alfred O Osoti, Anthony J Kelly, Stefania Livio, Jane E Norman, Zarko Alfirevic
BACKGROUND: Induction of labour is carried out for a variety of indications and using a range of methods. For women at low risk of pregnancy complications, some methods of induction of labour or cervical ripening may be suitable for use in outpatient settings. OBJECTIVES: To examine pharmacological and mechanical interventions to induce labour or ripen the cervix in outpatient settings in terms of effectiveness, maternal satisfaction, healthcare costs and, where information is available, safety...
September 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28898687/outcomes-of-mifepristone-usage-for-cervical-ripening-and-induction-of-labour-in-full-term-pregnancy-randomized-controlled-trial
#20
Oleg R Baev, Valentina P Rumyantseva, Oleg V Tysyachnyu, Olga A Kozlova, Gennady T Sukhikh
OBJECTIVE: The most commonly used approved indications for mifepristone in obstetrics include: termination of early pregnancy, cervical dilatation prior to abortion, labour induction in case of fetal death in utero. Fewer studies have been conducted on the effect of mifepristone on cervical ripening and induction of labour in term pregnancy with a live fetus. The aim of our study was to evaluate efficacy and safety of mifepristone use for cervical ripening and induction of labour versus expectant management in full-term pregnancy...
October 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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