keyword
MENU ▼
Read by QxMD icon Read
search

Mifepristone

keyword
https://www.readbyqxmd.com/read/29216406/high-throughput-h295r-steroidogenesis-assay-utility-as-an-alternative-and-a-statistical-approach-to-characterize-effects-on-steroidogenesis
#1
Derik E Haggard, Agnes L Karmaus, Matthew T Martin, Richard S Judson, R Woodrow Setzer, Katie Paul Friedman
The U.S. Environmental Protection Agency Endocrine Disruptor Screening Program and the Organization for Economic Co-operation and Development (OECD) have used the human adrenocarcinoma (H295R) cell-based assay to predict chemical perturbation of androgen and estrogen production. Recently, a high-throughput H295R (HT-H295R) assay was developed as part of the ToxCast program that includes measurement of 11 hormones, including progestagens, corticosteroids, androgens, and estrogens. To date, 2012 chemicals have been screened at one concentration; of these, 656 chemicals have been screened in concentration-response...
December 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29215040/sex-related-pharmacokinetic-differences-and-mechanisms-of-metapristone-ru486-metabolite
#2
Wenge Chen, Yingying Xiao, Jianzhong Chen, Jian Liu, Jingwei Shao, Tao Li, Yewei Zhu, Ji Ma, Yu Gao, Jichuang Wang, Jianguo Xu, Yusheng Lu, Lee Jia
Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated the sex-related pharmacokinetics of metapristone in both rats and dogs, and explored the related mechanisms of actions. Administration of metapristone to rats and dogs showed that plasma concentrations of metapristone (AUC, C max ) were significantly higher in female dogs and rats than in males...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29199806/selective-progesterone-receptor-modulators-new-possibilities-for-gynecologic-hormone-therapy
#3
Nanna Sarvilinna, Leila Unkila-Kallio, Päivi Härkki, Aila Tiitinen, Oskari Heikinheimo
Progesterone regulates several female reproductive functions. Progesterone and synthetic progestins derived from it have long been utilized in gynecology. The effects of these steroids in target cells are mediated via progesterone receptors, Progesterone receptors are also the target of action of selective progesterone receptor modulators. Of the molecules of this newer group of drugs, two are presently in clinical use. Mifepristone is used in nonsurgical abortion, in softening of the cervix before surgical abortion, and in the induction of labor in cases of intrauterine death...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29186429/extracellular-matrix-in-uterine-leiomyoma-pathogenesis-a-potential-target-for-future-therapeutics
#4
Md Soriful Islam, Andrea Ciavattini, Felice Petraglia, Mario Castellucci, Pasquapina Ciarmela
BACKGROUND: Uterine leiomyoma (also known as fibroid or myoma) is the most common benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can produce serious clinical symptoms, including excessive uterine bleeding, pelvic pain or pressure, infertility and pregnancy complications. Due to lack of effective medical treatments surgery has been a definitive choice for the management of this tumor. OBJECTIVE AND RATIONALE: Extracellular matrix (ECM) accumulation and remodeling are thought to be crucial for fibrotic diseases such as uterine leiomyoma...
November 23, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29182715/modulation-of-rat-50-khz-ultrasonic-vocalizations-by-glucocorticoid-signaling-possible-relevance-to-reward-and-motivation
#5
Nicola Simola, Elena Paci, Marcello Serra, Giulia Costa, Micaela Morelli
Background: Rats emit 50-kHz ultrasonic vocalizations (USVs) to communicate positive emotional states, and these USVs are increasingly being investigated in preclinical studies on reward and motivation. Although it is the activation of dopamine receptors that initiates the emission of 50-kHz USVs, non-dopaminergic mechanisms may modulate calling in the 50 kHz frequency band. To further elucidate these mechanisms, the present study investigated whether the pharmacological manipulation of glucocorticoid signaling influenced calling...
November 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29175274/provision-of-menstrual-regulation-with-medication-among-pharmacies-in-three-municipal-districts-of-bangladesh-a-situation-analysis
#6
Fauzia Akhter Huda, Hassan Rushekh Mahmood, Anadil Alam, Faisal Ahmmed, Farzana Karim, Bidhan Krishna Sarker, Nafis Al Haque, Anisuddin Ahmed
OBJECTIVE: To assess the provision of the combination of mifepristone-misoprostol for menstrual regulation (MR) in randomly selected urban pharmacies in Bangladesh. STUDY DESIGN: We conducted a cross-sectional survey among 553 pharmacy workers followed by 548 mystery client visits to the same pharmacies in three municipal districts during July 2014-December 2015. RESULTS: The survey found that 99% of pharmacy workers visited had knowledge of MR procedures but only two-thirds (67%) could state the legal time limit correctly; they mentioned misoprostol (86%) over mifepristone-misoprostol combination (78%) as a procedure of MR with medication (MRM); 36% reported knowing the recommended dosage of mifepristone-misoprostol combination; 70% reported providing information on effectiveness of the medicines; 50% reported recommending at least one follow-up visit to them; 63% reported explaining possible complications of using the medications; and 47% reported offering any post-MR contraception to their clients...
November 22, 2017: Contraception
https://www.readbyqxmd.com/read/29170088/simplified-medical-abortion-screening-a-demonstration-project
#7
Elizabeth G Raymond, Yi-Ling Tan, Rodica Comendant, Irina Sagaidac, Stelian Hodorogea, Melissa Grant, Patricio Sanhueza, Emigdio Van Pratt, Ginger Gillespie, Christy Boraas, Mark A Weaver, Ingrida Platais, Manuel Bousieguez, Beverly Winikoff
OBJECTIVES: To evaluate the safety and acceptability of outpatient medical abortion in selected women without a pretreatment ultrasound or pelvic examination. STUDY DESIGN: We conducted a prospective case-series study to estimate the incidence of serious adverse events (death, life-threatening event, hospitalization, transfusion, or any other medical problem that we judged to be significant), surgical completion of the abortion, and satisfaction in women provided with medical abortion without a pretreatment ultrasound or pelvic examination...
November 20, 2017: Contraception
https://www.readbyqxmd.com/read/29168561/combination-therapy-with-mifepristone-and-misoprostol-for-the-management-of-first-trimester-miscarriage-improved-success
#8
Angela Dunford, Rina Fyfe
BACKGROUND: First trimester miscarriage affects 20% of pregnancies. Medical management has a high degree of patient acceptance and does not increase the risk of infection. Mifepristone is an anti-progesterone shown to improve outcomes when used in conjunction with misoprostol for first trimester abortion. However, there have been conflicting results when it has been added to treatment regimens for miscarriage. METHODS: We performed a retrospective cohort analysis of women presenting to the Acute Gynaecology Service of our tertiary referral centre for miscarriage management from December 2010 until December 2013...
November 23, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29161343/distinct-reorganization-of-collagen-architecture-in-lipopolysaccharide-mediated-premature-cervical-remodeling
#9
Shanmugasundaram Nallasamy, Meredith Akins, Breanna Tetreault, Kate Luby-Phelps, Mala Mahendroo
Previous work has identified divergent mechanisms by which cervical remodeling is achieved in preterm birth (PTB) induced by hormone withdrawal (mifepristone) or lipopolysaccharide (LPS). Our current study aims to document how collagen architecture is modified to achieve premature cervical remodeling in mice treated with LPS as a model of infection induced inflammation. Cervices were collected on gestation day (d) 15 from mice with premature cervical ripening induced by LPS and compared to d15 and d18 controls as well as a hormone withdrawal preterm birth model...
November 17, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29139105/preoperative-medical-therapy-before-surgery-for-uterine-fibroids
#10
REVIEW
Anne Lethaby, Lucian Puscasiu, Beverley Vollenhoven
BACKGROUND: Uterine fibroids occur in up to 40% of women aged over 35 years. Some are asymptomatic, but up to 50% cause symptoms that warrant therapy. Symptoms include anaemia caused by heavy menstrual bleeding, pelvic pain, dysmenorrhoea, infertility and low quality of life. Surgery is the first choice of treatment. In recent years, medical therapies have been used before surgery to improve intraoperative and postoperative outcomes. However, such therapies tend to be expensive.Fibroid growth is stimulated by oestrogen...
November 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29133110/provision-of-medical-abortion-by-mid-level-healthcare-providers-in-kyrgyzstan-testing-an-intervention-to-expand-safe-abortion-services-to-under-served-rural-and-peri-urban-areas
#11
Brooke Ronald Johnson, Elmira Maksutova, Aigull Boobekova, Ainura Davletova, Chinara Kazakbaeva, Yelena Kondrateva, Sihem Landoulsi, Gunta Lazdane, Kubanychbek Monolbaev, Armando H Seuc Jo
OBJECTIVE: To demonstrate the feasibility and safety of training mid-level healthcare providers (midwives and family nurses) to provide medical abortion and post-abortion contraception in under-served areas in Kyrgyzstan. STUDY DESIGN: This was an implementation study at four referral facilities and 28 Felsher Obstetric Points in two districts to train their midwives and family nurses to deliver safe and effective abortion care with co-packaged mifepristone-misoprostol and provide contraceptives post-abortion...
November 10, 2017: Contraception
https://www.readbyqxmd.com/read/29121217/effect-of-ulipristal-acetate-and-mifepristone-at-emergency-contraception-dose-on-the-embryo-endometrial-attachment-using-an-in-vitro-human-trophoblastic-spheroid-and-endometrial-cell-co-culture-model
#12
Hang-Wun Raymond Li, Ying-Xing Li, Tian-Tian Li, Hongjie Fan, Ernest Hung-Yu Ng, William Shu-Biu Yeung, Pak-Chung Ho, Kai-Fai Lee
STUDY QUESTION: Do both ulipristal acetate (UPA) and mifepristone inhibit embryo-endometrial attachment at concentrations corresponding to the emergency contraception (EC) dose? SUMMARY ANSWER: Both UPA and mifepristone at concentrations corresponding to the EC dose do not have an inhibitory effect on embryo implantation, although mifepristone at a higher concentration appeared to have such an effect. WHAT IS KNOWN ALREADY: Levonorgestrel is commonly used for EC, but it only acts through inhibition of ovulation...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29108160/embryo-survival-after-mifepristone-a-systematic-review-of-the-literature
#13
Mary Davenport, George Delgado, Matthew P Harrison, Veronica Khauv
No abstract text is available yet for this article.
2017: Issues in Law & Medicine
https://www.readbyqxmd.com/read/29098176/transient-prepubertal-mifepristone-treatment-normalizes-deficits-in-contextual-memory-and-neuronal-activity-of-adult-male-rats-exposed-to-maternal-deprivation
#14
Manila Loi, Ratna Angela Sarabdjitsingh, Andromachi Tsouli, Stephanie Trinh, Marit Arp, Harmen J Krugers, Henk Karst, Ruud van den Bos, Marian Joëls
Early life adversity is a well-known risk factor for behavioral dysfunction later in life, including the formation of contextual memory; it is also (transiently) accompanied by hyperactivity of the stress system. We tested whether mifepristone (MIF) treatment, which among other things blocks glucocorticoid receptors (GRs), during the prepubertal period [postnatal days (PND)26-PND28] normalizes memory deficits in adult male rats exposed to 24-h maternal deprivation (MD) at PND3. MD reduced body weight gain and increased basal corticosterone (CORT) levels during the PND26, but not in adulthood...
September 2017: ENeuro
https://www.readbyqxmd.com/read/29080885/roles-of-mifepristone-on-the-regulation-of-cytotoxic-lymphocytes-and-regulatory-t-cells
#15
Linxiang Liu, Feng Zhou, Jiale Qin, Zhida Qian, Lili Huang
OBJECTIVE: To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua. SETTING: In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects...
October 28, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29078070/endocrine-disruptors-affect-larval-zebrafish-behavior-testing-potential-mechanisms-and-comparisons-of-behavioral-sensitivity-to-alternative-biomarkers
#16
Thomas W K Fraser, Abdolrahman Khezri, Anna M Lewandowska-Sabat, Theodore Henry, Erik Ropstad
Larval zebrafish (Danio rerio) are a tool for assessing endocrine disruption during early development. Here, we investigated the extent to which a simple light/dark behavioral test at five days post fertilization could compliment current methods within the field. We exposed fertilized embryos to hormones (17β-estradiol, testosterone, dihydrotestosterone, 11-ketotestosterone, thyroxine, triiodothyronine, progesterone, and hydrocortisone) and other relevant compounds (17α ethinylestradiol, bisphenol A, bisphenol S, nonylphenol, flutamide, nilutamide, linuron, drospirenone, potassium perchlorate, mifepristone, and fadrozole) to screen for behavioral effects between 96 and 118h post fertilization (hpf)...
October 6, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29074407/adaptation-of-vectors-and-drug-inducible-systems-for-controlled-expression-of-transgenes-in-the-tumor-microenvironment
#17
Joanna Poutou, Maria Bunuales, Manuela Gonzalez-Aparicio, Beatriz German, Ines Zugasti, Ruben Hernandez-Alcoceba
Biological therapies based on recombinant proteins such as antibodies or cytokines are continuously improving the repertoire of treatments against cancer. However, safety and efficacy of this approach is often limited by inappropriate biodistribution and pharmacokinetics of the proteins when they are administered systemically. Local administration of gene therapy vectors encoding these proteins would be a feasible alternative if they could mediate long-term and controlled expression of the transgene after a single intratumoral administration...
October 24, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29061806/mifepristone-has-limited-activity-to-enhance-the-in-vivo-efficacy-of-docetaxel-and-enzalutamide-against-bone-metastatic-and-castration-resistant-prostate-cancer
#18
Yang Yang, Xin Li, Kenza Mamouni, Omer Kucuk, Daqing Wu
BACKGROUND: Mifepristone has gained great interest in its potential as a novel agent against human cancers, including prostate cancer (PCa). However, recent clinical trials using mifepristone in PCa and other cancers have been disappointing. We evaluated the in vitro and in vivo activities of mifepristone, in combination with docetaxel and enzalutamide, against bone metastatic castration-resistant PCa. MATERIALS AND METHODS: The effects of mifepristone, alone or in combination with docetaxel or enzalutamide, on PCa cell viability, in vitro, were determined by the colorimetric assay...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29049861/mifepristone-misoprostol-for-menstrual-regulation-in-public-sector-facilities-in-bangladesh
#19
Anadil Alam, Tatyana Lotarevich, Tapash R Das, Laura Reichenbach, Hillary Bracken
OBJECTIVE: To examine the use of mifepristone and misoprostol for menstrual regulation among Bangladeshi women attending public sector facilities. METHODS: In a prospective study, women (aged ≥18 years) with up to 9 weeks of amenorrhea were enrolled at 24 government health facilities in Bangladesh from November 2012 to June 2015. Paramedics or female welfare visitors provided most menstrual regulation care. Participants took 200 mg mifepristone followed by 800 μg buccal misoprostol after 24 hours, and were asked to return to the clinic 10-14 days later for clinical assessment and an exit interview...
October 19, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29046138/usefulness-of-simultaneous-measurement-of-plasma-steroids-including-precursors-for-the-evaluation-of-drug-effects-on-adrenal-steroidogenesis-in-rats
#20
Tomoaki Tochitani, Akihito Yamashita, Izumi Matsumoto, Mami Kouchi, Yuta Fujii, Izuru Miyawaki, Toru Yamada, Kiyoko Bando
The aim of this study was to evaluate the usefulness of simultaneous measurement of plasma steroids, including precursors, for the evaluation of drug effects on adrenal steroidogenesis in vivo. Plasma concentrations of corticosterone and its precursors were examined in rats dosed with compounds that affect adrenal steroidogenesis via different modes of action as well as the relationships of the changes with blood chemistry and adrenal histopathology. Male rats were dosed with tricresyl phosphate, aminoglutethimide, trilostane (TRL), metyrapone (MET), ketoconazole (KET), or mifepristone for 7 days...
August 2017: Toxicologic Pathology
keyword
keyword
114795
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"