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Anahid Nourian, Mostafa Mohammadi, Mohammad-Taghi Beigmohammadi, Mohammad Taher, Zohreh Dadvar, Masoume Malekolkottab, Masoud Ramezani, Hossein Khalili
AIM: Adequacy of enteral nutrition (EN) alone as stress ulcer prophylaxis (SUP) is controversial. The aim of this study was to compare efficacy of EN alone and ranitidine plus EN as SUP. METHOD: Critically ill adults with indications to receive SUP were randomized to ranitidine 50 mg IV every 8 h plus EN (SUP) or EN alone (non-SUP) group for 7 days. Besides, endoscopy was performed at the time of recruitment and on day 7. RESULTS: During the study period, only one patient in each group of SUP and non-SUP experienced gastrointestinal bleeding...
May 18, 2018: Journal of Comparative Effectiveness Research
Xuehua Piao, Shuangdi Li, Xiaodan Sui, Lianyi Guo, Xingmei Liu, Hongmei Li, Leming Gao, Shusheng Cai, Yanrong Li, Tingting Wang, Baohai Liu
Gastric ulcer (GU) is a main threat to public health. 1-Deoxynojirimycin (DNJ) has antioxidant and anti-inflammatory properties and may prevent GU but related mechanism remains unclear. DNJ was extracted from the supernatants of Bacillus subtilis by using ethanol and purified by using CM-Sepharose chromatography. A GU mouse model was induced by indomethacin. The functional role of DNJ in GU mice was explored by measuring the main molecules in the NF-KappaB pathway. After the model establishment, 40 GU mice were evenly assigned into five categories: IG (received vehicle control), LG (10 μg DNJ daily), MG (20 μg DNJ daily), HG (40 μg DNJ daily), and RG (0...
2018: Frontiers in Pharmacology
Meric Selbes, Wilson Beita-Sandí, Daekyun Kim, Tanju Karanfil
N-nitrosodimethylamine (NDMA), a probable human carcinogen disinfection by-product, has been detected in chloraminated drinking water systems. Understanding its formation over time is important to control NDMA levels in distribution systems. The main objectives of this study were to investigate the role of chloramine species (i.e., monochloramine and dichloramine); and the factors such as pH, sulfate, and natural organic matter (NOM) influencing the formation of NDMA. Five NDMA precursors (i.e., dimethylamine (DMA), trimethylamine (TMA), N,N-dimethylisopropylamine (DMiPA), N,N-dimethylbenzylamine (DMBzA), and ranitidine (RNTD)) were carefully selected based on their chemical structures and exposed to varying ratios of monochloramine and dichloramine...
April 16, 2018: Water Research
Edilane Rodrigues Dantas de Araújo, Gerlane Coelho Bernardo Guerra, Daline Fernandes de Souza Araújo, Aurigena Antunes de Araújo, Júlia Morais Fernandes, Raimundo Fernandes de Araújo Júnior, Valéria Costa da Silva, Thaís Gomes de Carvalho, Leandro de Santis Ferreira, Silvana Maria Zucolotto
Kalanchoe brasiliensis and Kalanchoe pinnata are used interchangeably in traditional medicine for treating peptic ulcers and inflammatory problems. In this context, this study aims to characterize the chemical constituents and evaluate the gastroprotective activity of the leaf juices of the two species in acute gastric lesions models. Thin Layer Chromatography (TLC) and Ultra High Performance Liquid Chromatography coupled to Mass Spectrometer (UHPLC-MS) were performed for chemical characterization. Wistar rats were pre-treated orally with leaf juices (125, 250 and 500 mg/kg) or ranitidine (50 mg/kg)...
April 24, 2018: International Journal of Molecular Sciences
L A Gurien, K Stallings-Archer, S D Smith
BACKGROUND: Necrotizing enterocolitis (NEC) persists as the most common and serious gastrointestinal disorder among premature infants. Lactococcus lactis (LL), a lactic acid producing bacteria commonly found in buttermilk and cheese products, has several unique properties making it an ideal probiotic for neonates. We evaluated if the probiotic LL prevents development of NEC in a preterm rabbit model with Cronobacter sakazakii (CS). METHODS: Two-day preterm New Zealand white rabbit pups were randomly assigned to three diets: control (no additives), CS, and CS+LL...
2018: Journal of Neonatal-perinatal Medicine
Kevin Singh, Paul Maung, Kousigan Vadivelu
No abstract text is available yet for this article.
April 10, 2018: American Journal of Therapeutics
Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Allen Karstens, Hannah Jones, Sharon DeMorrow, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Gianfranco Alpini, Steven Smith, Austin Akers, Victoria Meadows, Heather Francis
BACKGROUND: Primary Sclerosing Cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that: (i) histamine (HA) increases biliary hyperplasia via H1/H2 histamine receptors (HRs) and (ii) HA levels increase and mast cells (MCs) infiltrate during PSC and CCA. We aimed to examine the effects of chronic treatment with H1/H2HR antagonists on PSC and CCA. METHODS: Wild-type and Mdr2-/- mice were treated by osmotic minipumps with saline, mepyramine or ranitidine (10mg/kg BW/day) or a combination of mepyramine/ranitidine for 4 wks...
March 30, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Mingizem Gashaw Seid, Kangwoo Cho, Changha Lee, Hyun-Mee Park, Seok Won Hong
Ranitidine (RNT) has been an important tertiary amine precursor of N-nitrosodimethylamine (NDMA) in chlorine-based water treatment, due to reaction with monochloramine (NH2 Cl) with exceptionally high molar yields up to 90%. This study examined the effects of nitrite ions (NO2 - ) on the kinetics of NDMA formation during the chloramination of RNT under variable concentrations of dissolved oxygen (DO, 0.7-7.5mg/L), RNT (5-30μM), NH2 Cl (5-20mM), NO2 - or NO3 - (0-2mM) and pH (5.6-8.6). In the absence of the NO2 - , the ultimate molar yield of NDMA after 6h of reaction was primarily influenced by [DO] and pH, while marginally affected by initial [RNT] and [NH2 Cl]...
March 26, 2018: Science of the Total Environment
B Claus, T Bauters, G Laureys
This article describes the implications of shortages of pharmaceutical products used in conditioning and supportive care regimens of pediatric patients undergoing a hematopoietic stem cell transplantation in a tertiary care hospital. Between July 2011 and July 2016, a total of 84 individual shortages, affecting 22 different drugs (79.8% supportive care drugs; 20.2% chemotherapeutics) were detected with a mean duration of 85 days (SD 138) per individual drug shortage. Eighteen shortages were critical and very urgent...
January 1, 2018: Journal of Oncology Pharmacy Practice
Qian Zhang, Cheng-Ning Tan, Ya-Li Wang, Wen-Jing Liu, Feng-Qing Yang, Hua Chen, Zhi-Ning Xia
For lead compound discovery from natural products, hollow fiber cell fishing with chromatographic analysis was a newly developed method. In this study, an adsorbed hollow fiber based biological fingerprinting method was firstly developed to discover potential platelet aggregation inhibitors from Danshen-Honghua decoction. Platelets were seeded on the fiber and their survival rate was tested. Results indicated that more than 92% platelets survived during the whole operation process. Ranitidine and tirofiban were used as positive and negative control respectively to verify the reliability of the presented approach...
March 23, 2018: Journal of Separation Science
Afsaneh Shakeri, Mohammad Hashem Hashempur, Mahdieh Mojibian, Fatemeh Aliasl, Soodabeh Bioos, Fatemeh Nejatbakhsh
Quince (Cydonia oblonga Mill) is a popular medicinal herb in different traditional medicines. Concentrated quince fruit extract, also known as quince sauce (QS), is traditionally used for the treatment of a variety of gastrointestinal disorders. The aim of this study was to compare the efficacy of QS versus ranitidine on gastroesophageal reflux disease (GERD) in pregnant women. We compared the efficacy of 4 weeks of ranitidine (150 mg, twice daily) with the efficacy of QS (10 mg, after meals) on 137 pregnant women with GERD...
March 19, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Nancy N Shahin, Noha F Abdelkader, Marwa M Safar
The advent of angiotensin II type 1 receptor blockers (ARBs) as intriguing gastroprotective candidates and the superior pharmacokinetics and pharmacodynamics displayed by irbesartan compared to many other ARBs raised the interest to investigate its gastroprotective potential in a rat model of gastric injury. Irbesartan (50 mg/Kg) was orally administered to male Wistar rats once daily for 14 days; thereafter gastric injury was induced by indomethacin (60 mg/Kg, p.o). Irbesartan reduced gastric ulcer index, gastric acidity, and ameliorated indomethacin-induced gastric mucosal apoptotic and inflammatory aberrations, as demonstrated by hampering caspase-3, prostaglandin E2 and tumor necrosis factor-alpha levels and cyclooxygenase-2 mRNA expression...
March 9, 2018: Scientific Reports
Rusen Zou, Xiaobin Liao, Lei Zhao, Baoling Yuan
Formation of toxic N-nitrosodimethylamine (NDMA) by chloramination of ranitidine, a drug to block histamine, was still an ongoing issue and posed a risk to human health. In this study, the effect of ozonation prior to chloramination on NDMA formation and the transformation pathway were determined. Influencing factors, including ozone dosages, pH, hydroxyl radical scavenger, bromide, and NOM, were studied. The results demonstrated that small ozone dosage (0.5 mg/L) could effectively control NDMA formation from subsequent chloramination (from 40 to 0...
February 28, 2018: Environmental Science and Pollution Research International
Kristin E Follman, Marilyn E Morris
Renal impairment (RI) is a major health concern with a growing prevalence. RI leads to various physiologic changes, in addition to a decrease in glomerular filtration rate, that impact the pharmacokinetics (PK) and, specifically, the renal clearance (CLR ) of compounds, including alterations of drug transporter (DT)/drug-metabolizing enzyme expression and activity, as well as protein binding. The objectives of this study were to use a physiologically based pharmacokinetic modeling platform to 1) assess the impact of alterations in DT expression, toxin-drug interactions (TDIs), and free fraction (fu ) on PK predictions for the organic cation transporter 2/multidrug and toxin extrusion protein 1 substrate metformin in RI populations; and 2) use available in vitro data to improve predictions of CLR for two actively secreted substrates, metformin and ranitidine...
May 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Behzad Darbasizadeh, Hamidreza Motasadizadeh, Behrouz Foroughi-Nia, Hassan Farhadnejad
The present study describes the fabrication of Tripolyphosphate (TPP)-crosslinked nanofibrous mats based on chitosan for use as a floating gastro-retentive delivery system. TPP-crosslinked chitosan (CH)/poly (ethylene oxide) (PEO)- ranitidine hydrochloride (RH) electrospun nanofibers (75.27 ± 2.10 nm) were prepared by electrospinning 70% v/v acetic acid solutions, and followed by crosslinking by TPP anions. The mechanical, structural and morphological properties of the prepared nanofibers were evaluated via tensile testing, XRD, FT-IR, TGA, NMR, AFM and SEM experimental techniques...
May 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
İnsu Yılmaz, Murat Türk
Ranitidine is a well-tolerated H2-receptor antagonist commonly used in peptic ulcer treatment and stress ulcer prophylaxis. Anaphylaxis is rarely observed with ranitidine. We report the case of a patient who developed anaphylaxis after intravenous injection of ranitidine for acute COPD exacerbation. This article underlines the importance of awareness that in COPD acute exacerbation treatment, ranitidine, which is usually administered with methylprednisolone, also has anaphylaxis potential.
July 2017: Turkish Thoracic Journal
Michael J Haas, Monica Plazarte, Ayham Chamseddin, Luisa Onstead-Haas, Norman C W Wong, Gabriela Plazarte, Arshag D Mooradian
In a recent high throughput analysis to identify drugs that alter hepatic apolipoprotein A-I (apo A-I) expression, histamine receptor one (H1 ) antagonists emerged as potential apo A-1 inducing drugs. Thus the present study was undertaken to identify some of the underlying molecular mechanisms of the effect of antihistaminic drugs on apo AI production. Apo A-I levels were measured by enzyme immunoassay and Western blots. Apo A-I mRNA levels were measured by reverse transcription real-time PCR using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as the internal control...
March 15, 2018: European Journal of Pharmacology
Aroosa Ishtiaq Butt, Bushra Tayyaba Khan, Asma Khan, Qamar-Uz-Zaman Khan
BACKGROUND: Gastroparesis and GERD occur concomitantly in 40 percent of the cases. Prokinetic drugs and acid blockers are employed as the main treatment modality. Ranitidine is an acid blocker with additional prokinetic activity and Itopride is a known prokinetic drug. This study was designed to observe the synergistic potentiating prokinetic effect of Ranitidine on itopride on isolated duodenum of rabbits. METHODS: Ranitidine (10-5-10-3) and itopride (10-6-10-5) were added in increasing concentrations to isolated duodenum of rabbits and contractions were recorded on PowerLab Data acquisition unit AHK/214...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
Pravin K Mutiyar, Sanjay Kumar Gupta, Atul Kumar Mittal
The river Yamuna is a major tributary of river Ganges and is a major source of freshwater in the National Capital Territory (NCT) catering 16.8 million people. This is the first report on occurrence, fate and ecotoxicological risk assessment of various pharmaceuticals active compounds (PhACs) in the Yamuna river. In this study, spatial and temporal distribution of nine PhACs "aspirin, ibuprofen, paracetamol, caffeine, ranitidine, diclofenac, carbamazepine, codeine, and diazepam", belonging to different therapeutic groups have been reported...
April 15, 2018: Ecotoxicology and Environmental Safety
Marleen Julia Meyer, Tina Seitz, Jürgen Brockmöller, Mladen Vassilev Tzvetkov
BACKGROUND: Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is highly genetically variable. Twelve major alleles confer partial or complete loss of OCT1 activity. The effects of these polymorphisms are highly substrate-specific and therefore difficult to predict. The renal transporter OCT2 has a common polymorphism, Ala270Ser, which was reported to affect OCT2 activity...
2017: PloS One
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