Han-Sung Cho, Tae Woo Kwon, Ji-Hun Kim, Rami Lee, Chun-Sik Bae, Hyoung-Chun Kim, Jong-Hoon Kim, Sun-Hye Choi, Ik-Hyun Cho, Seung-Yeol Nah
Gintonin, newly extracted from ginseng, is a glycoprotein that acts as an exogenous lysophosphatidic acid (LPA) receptor ligand. This study aimed to demonstrate the in vivo preventive effects of gintonin on gastric damage. ICR mice were randomly assigned to five groups: a normal group (received saline, 0.1 mL/10 g, p.o.); a control group (administered 0.3 M HCl/ethanol, 0.1 mL/10 g, p.o.) or indomethacin (30 mg/kg, p.o.); gintonin at two different doses (50 mg/kg or 100 mg/kg, p.o.) with either 0.3 M HCl/ethanol or indomethacin; and a positive control (Ranitidine, 40 mg/kg, p...
November 24, 2023: International Journal of Molecular Sciences