Rita Haldar, Lee Shaashua Berger, Ella Rossenne, Arielle Radin, Anabel Eckerling, Elad Sandbank, Erica K Sloan, Steve W Cole, Shamgar Ben-Eliyahu
We recently showed that a minimally-invasive removal of MDA-MB-231HM primary tumors (PTs) and elimination of their secreted factors (including IL-6, IL-8, VEGF, EGF, PDGF-aa, MIF, SerpinE1, and M-CSF), caused regression of spontaneous micro-metastases into a non-growing dormant state. To explore the underlying mechanisms and potential clinical ramifications of this phenomenon, we herein used the MDA-MB-231HM human breast cancer cell-line, in-vitro, and in vivo following orthotopic implantation in immune-deficient BALB/C nu/nu mice...
January 13, 2023: Brain, Behavior, and Immunity