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Cefpodoxime

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https://www.readbyqxmd.com/read/28685856/the-performance-of-a-resazurin-chromogenic-agar-plate-with-a-combined-disc-method-for-rapid-screening-of-extended-spectrum-%C3%AE-lactamases-ampc-%C3%AE-lactamases-and-co-%C3%AE-lactamases-in-enterobacteriaceae
#1
Yothin Teethaisong, Katie Evans, Ismini Nakouti, Kanokwan Tiamyom, James R Ketudat-Cairns, Glyn Hobbs, Griangsak Eumkeb
A resazurin chromogenic agar (RCA) along with combined disc method has been developed as a promising method for rapid screening of extended-spectrum-β-lactamase (ESBL), AmpC β-lactamase, and co-production of ESBL and AmpC. Cefpodoxime (CPD) discs supplemented with and without clavulanic acid (CA), cloxacillin (CX), or CA+CX were evaluated against 86-molecularly confirmed β-lactamase-producing Enterobacteriaceae, including 15 ESBLs, 32 AmpCs, 9 co-producers of ESBL and AmpC, and 30 carbapenemase producers...
July 7, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28653931/impact-of-different-organic-acids-on-solubility-enhancement-of-cefpodxime-proxetil-immediate-release-tablet-and-its-stability-studies
#2
Sabahat Jabeen, Fouzia Hassan, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Fozia Israr, S M Farid Hasan, Rehana Saeed, Sadaf Farooqi
Cefpodoxime proxetil is a third generation cephalosporin antibiotic demonstrates pH dependent solubility and is highly soluble only in acidic pH. The purpose of this investigation was to design and develop immediate release tablets of cefpodoxime proxetil by direct compression method and determine the effect of different solid buffers (organic acids) such as fumaric acid (formulations F1-F4), maleic acid (formulations M1-M4) and citric acid (formulations C1-C4) by using cefpodoxime and acid in the ratios of 4:1, 2:1, 1:1 and 1:2 to achieve pH-independent release of the drug...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28613139/evaluation-of-the-relationship-between-the-minimum-inhibitory-concentration-of-ceftiofur-and-third-generation-cephalosporins-in-escherichia-coli-isolates-from-food-producing-animals
#3
Mototaka Hiki, Yasuhito Shimizu, Michiko Kawanishi, Manao Ozawa, Hitoshi Abo, Akemi Kojima, Ryoji Koike, Satowa Suzuki, Tetsuo Asai, Shuichi Hamamoto
To enable future comparison of the antimicrobial susceptibility data between bacteria obtained from animals and humans, it is necessary to compare the relationships between minimum inhibitory concentrations (MICs) of veterinary and human medicine. We evaluated the relationship between the MIC of ceftiofur (CTF) and the MICs of other third-generation cephalosporins (TGCs): cefotaxime (CTX), cefpodoxime (CPDX), and ceftazidime (CAZ), determined by the broth microdilution method using 118 cefazolin-resistant Escherichia coli isolates from food-producing animals...
June 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28553414/esbl-production-among-e-coli-and-klebsiella-spp-causing-urinary-tract-infection-a-hospital-based-study
#4
Pooja Shakya, Dhiraj Shrestha, Elina Maharjan, Vijay K Sharma, Rabin Paudyal
INTRODUCTION: Increase in extended-spectrum β-lactamases (ESBL) producing microbes in recent years has led to limitations of treatment options. This study aimed to assess the prevalence of ESBL producing E. coli and Klebsiella spp. at a tertiary hospital in Nepal. METHODS: A total of 2209 non-repetitive mid-stream urine (MSU) samples were collected during the study period (March to September 2014). Identification of the isolates was done by Gram's staining followed by biochemical tests...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28499129/occurrence-of-antimicrobial-resistance-bacteria-in-the-yodo-river-basin-japan-and-determination-of-beta-lactamases-producing-bacteria
#5
Naoyuki Yamashita, Yohei Katakawa, Hiroaki Tanaka
Antimicrobial resistant bacteria are widespread in aquatic environments. The aim of the present study was to obtain information on the occurrence of bacteria with antimicrobial resistance and their multiple antimicrobial resistance (MAR) patterns in a river basin in Japan. In addition, the occurrence of fecal bacteria producing extended-spectrum beta-lactamases (ESBLs) and metallo-beta-lactamase (MBL) in the aquatic environment was determined. Among the Escherichia coli isolates recovered from river samples upstream, 55% isolates were resistant to at least one antimicrobial and 18% were MAR...
May 9, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28455578/-epidemiology-diagnostics-therapy-prevention-and-management-of-uncomplicated-bacterial-outpatient-acquired-urinary-tract-infections-in-adult-patients-update-2017-of-the-interdisciplinary-awmf-s3-guideline
#6
REVIEW
J Kranz, S Schmidt, C Lebert, L Schneidewind, W Vahlensieck, U Sester, R Fünfstück, S Helbig, W Hofmann, E Hummers, M Kunze, E Kniehl, K Naber, F Mandraka, B Mündner-Hensen, G Schmiemann, F M E Wagenlehner
BACKGROUND: Update of the 2010 published evidence-based S3 guideline on epidemiology, diagnostics, therapy and management of uncomplicated, bacterial, outpatient-acquired urinary tract infections in adult patients. The guideline contains current evidence for the rational use of antimicrobial substances, avoidance of inappropriate use of certain antibiotic classes and development of resistance. METHODOLOGY: The update was created under the leadership of the German Association of Urology (DGU)...
June 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28444315/towards-the-early-detection-of-%C3%AE-lactamase-producing-enterobacteriaceae-by-maldi-tof-ms-analysis
#7
Marina Oviaño, Marta Gómara, Maria José Barba, María José Revillo, Luis Pedro Barbeyto, Germán Bou
Objectives: Development of a novel MALDI-TOF MS-based method for the rapid detection of ESBL-producing Enterobacteriaceae. Methods: The method was evaluated in terms of sensitivity, specificity and turnaround time regarding the antibiotic used (cefotaxime, ceftazidime, ceftriaxone, cefpodoxime or cefepime) and the performance of the automated MBT STAR-BL software (Bruker Daltonik GmbH, Germany) relative to qualitative interpretation of spectra for detecting β-lactamase resistance by MALDI-TOF MS (Bruker Daltonik) in a collection of 11 isogenic Escherichia coli control strains expressing different β-lactamases...
April 24, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28376716/in-vitro-transfer-of-methicillin-resistance-determinants-meca-from-methicillin-resistant-staphylococcus-aureus-mrsa-to-methicillin-susceptible-staphylococcus-aureus-mssa
#8
Asinamai Athliamai Bitrus, Zakaria Zunita, Siti Khairani Bejo, Sarah Othman, Nur Adilah Ahmad Nadzir
BACKGROUND: Staphylococcus aureus more than any other human pathogen is a better model for the study of the adaptive evolution of bacterial resistance to antibiotics, as it has demonstrated a remarkable ability in its response to new antibiotics. This study was designed to investigate the in vitro transfer of mecA gene from methicillin resistant S. aureus to methicillin susceptible S. aureus. RESULT: The recipient transconjugants were resistant to erythromycin, cefpodoxime and were mecA positive...
April 4, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28368864/characterization-of-esbl-producing-escherichia-coli-recovered-from-companion-dogs-in-tai-an-china
#9
Song Li, Junhe Liu, Yufa Zhou, Zengmin Miao
INTRODUCTION: Animals are considered to be reservoirs of extended-spectrum beta-lactamase (ESBL)-producing bacteria, but few epidemiological data on ESBL-producing Escherichia coli urinary tract isolates in pet dogs are available in China. METHODOLOGY: This study was conducted to describe the prevalence and characterization of ESBL producers among E. coli urinary tract isolates from pet dogs in Tai'an, China. RESULTS: A total of 118 E. coli were obtained from urinary samples of 80 companion dogs suffering from acute or chronic cystitis, of which three isolates from different dogs were ESBL producers...
March 31, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28350183/prevalence-and-antimicrobial-susceptibility-of-enterobacteriaceae-isolated-from-retail-pepper-in-vietnam
#10
Tetsuya Harada, Ryoko Yamane, Van Chinh Dang, Do Phuc Nguyen, Thi Anh Dao Nguyen, Michio Jinnai, Shinya Yonogi, Ryuji Kawahara, Masashi Kanki, Takao Kawai, Kentaro Kawatsu, Yuko Kumeda, Yuji Isegawa, Yoshimasa Yamamoto
To investigate the microbial quality of retail pepper in Vietnam, the enumeration and detection of Enterobacteriaceae and the screening of cefotaxime (CTX)-resistant coliforms were performed by using 84 commercial samples. Although Enterobacteriaceae were isolated from 78 samples, the number of Enterobacteriaceae was lower than 1.0 log CFU/g in 46 samples. For the detection of Enterobacteriaceae with the International Organization for Standardization methods, Salmonella spp., Escherichia coli , Klebsiella pneumoniae , Cronobacter sakazakii , and Enterobacter cloacae complex were isolated from 5, 12, 36, 19, and 30 samples, respectively...
March 28, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28137463/validated-hplc-method-for-the-pharmacokinetic-study-of-oral-extended-release-cefpodoxime-proxetil-chitosan-alginate-beads-in-rabbits
#11
Ali Mujtaba, Kanchan Kohli
The aim of this study is to develop a simple and applicable HPLC method for the detection of cefpodoxime acid (CFA) in rabbit plasma after oral administration of cefpodoxime proxetil (CFP) loaded chitosan-alginate (CH-ALG) beads formulation. CFP is a prodrug that is deesterified in vivo to its active metabolite CFA to exhibit antibiotic activity. Chromatographic separation of CFA and internal standard (IS) was achieved by a RP18(C18), Phenomenax®100, (250×4.6mm) with the mobile phase consisting of (0.02mol/l (20mM) ammonium acetate solution and acetonitrile (92:8, v/v, pH=4...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28096976/effect-of-handrubbing-using-locally-manufactured-alcohol-based-handrubs-in-paediatric-wards-in-harare-zimbabwe
#12
Muchaneta Gudza-Mugabe, Marcelyn T Magwenzi, Hilda A Mujuru, Mutsa Bwakura-Dangarembizi, Valerie Robertson, Alexander M Aiken
We assessed bacterial contamination of hands of adults present in paediatric wards in two tertiary-care hospitals in Harare, Zimbabwe and the microbiologic efficacy of locally-manufactured alcohol-based hand rub (ABHR). During unannounced visits, samples were collected using hand-print and hand-rinse methods. Samples were collected from 152 individuals (16 nurses, 10 doctors, 28 students, 86 parents/guardians, 12 others). Contamination of hands with Gram-negative bacteria was found in 91% of adults tested with a mean of 14...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27942365/isolation-antimicrobial-susceptibility-profile-and-detection-of-sul1-blatem-and-blashv-in-amoxicillin-clavulanate-resistant-bacteria-isolated-from-retail-sausages-in-kampar-malaysia
#13
Lih-Shin Tew, Li-Yen She, Choy-Hoong Chew
BACKGROUND: Due to the overuse of antibiotics in livestock as a growth-promoting agent, the emergence of multi-antibiotic resistant bacteria is becoming a concern. OBJECTIVES: In this study, we aimed to detect the presence and discover the molecular determinants of foodborne bacteria in retail sausages resistant towards the antibacterial agent amoxicillin-clavulanate. METHODS: Two grams of sausages were chopped into small pieces and transferred into sterile Luria-Bertani (LB) enrichment broths overnight before they were plated on MacConkey agar petri dishes...
October 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27939093/susceptibility-to-cephalosporin-combinations-and-aztreonam-avibactam-among-third-generation-cephalosporin-resistant-enterobacteriaceae-recovered-on-hospital-admission
#14
MULTICENTER STUDY
Alexander Mischnik, Philipp Baumert, Axel Hamprecht, Anna Rohde, Silke Peter, Susanne Feihl, Johannes Knobloch, Hanna Gölz, Axel Kola, Birgit Obermann, Christiane Querbach, Matthias Willmann, Friedemann Gebhardt, Evelina Tacconelli, Petra Gastmeier, Harald Seifert, Winfried V Kern
As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the β-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC50/90 values were 0.25-4 mg/L for cefepime/tazobactam, 0.25-2 mg/L for ceftazidime/avibactam, 0.125-0.5 mg/L for ceftaroline/avibactam, 0...
February 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27904747/comparing-the-disk-diffusion-and-agar-dilution-tests-for-neisseria-gonorrhoeae-antimicrobial-susceptibility-testing
#15
Hsi Liu, Thomas H Taylor, Kevin Pettus, Steve Johnson, John R Papp, David Trees
BACKGROUND: We assessed the validity of testing for antimicrobial susceptibility of clinical and mutant Neisseria gonorrhoeae (GC) isolates by disk diffusion in comparison to agar dilution, and Etest® (bioMerieux, France), respectively, for three third generation extended spectrum cephalosporins (ESC): ceftriaxone (CRO), cefixime (CFX), and cefpodoxime (CPD). METHODS: One hundred and five clinical isolates and ten laboratory-mutants were tested following Clinical Laboratory Standard Institute (CLSI) and manufacturer's standards for each of the three methods...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27694724/prevalence-and-multidrug-resistance-of-escherichia-coli-from-community-acquired-infections-in-lagos-nigeria
#16
Eyitayo O Adenipekun, Charlene R Jackson, Hazem Ramadan, Bamidele A Iwalokun, Kolawole S Oyedeji, Jonathan G Frye, John B Barrett, Lari M Hiott, Tiffanie A Woodley, Afolabi Oluwadun
INTRODUCTION: The emergence of multidrug resistance (MDR; resistance to ≥ 2 more antimicrobials) in Escherichia coli is of concern due to complications encountered in treatment. METHODOLOGY: In this study, prevalence, antimicrobial resistance, and genetic characteristics of MDR community isolates of E. coli from Lagos, Nigeria were determined. Urine and stool samples were obtained from outpatients attending Lagos State hospitals and from animal handlers in abattoirs, poultries, and open markets, from December 2012 to July 2013...
September 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27598630/first-report-of-tem-104-shv-99-shv-108-and-shv-110-producing-klebsiella-pneumoniae-from-iran
#17
Shahram Shahraki-Zahedani, Shahnaz Rigi, Mohammad Bokaeian, Alireza Ansari-Moghaddam, Mehdi Moghadampour
INTRODUCTION: Extended-spectrum beta-lactamases (ESBLs) are bacterial enzymes capable of hydrolyzing beta-lactams. The aim of this study was to describe the prevalence of TEM- and SHV-type ESBL-producing Klebsiella pneumoniae strains in Zahedan, Southeast Iran. METHODS: A total of 170 non-repetitive K. pneumoniae strains were collected from patients referred to three teaching hospitals of Zahedan. Antibiotic susceptibility testing was determined for 17 antibiotics using the Kirby-Bauer disc diffusion method...
July 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27494134/esbl-detection-comparison-of-a-commercially-available-chromogenic-test-for-third-generation-cephalosporine-resistance-and-automated-susceptibility-testing-in-enterobactericeae
#18
Mohamed Ramadan El-Jade, Marijo Parcina, Ricarda Maria Schmithausen, Christoph Stein, Alina Meilaender, Achim Hoerauf, Ernst Molitor, Isabelle Bekeredjian-Ding
Rapid detection and reporting of third generation cephalosporine resistance (3GC-R) and of extended spectrum betalactamases in Enterobacteriaceae (ESBL-E) is a diagnostic and therapeutic priority to avoid inefficacy of the initial antibiotic regimen. In this study we evaluated a commercially available chromogenic screen for 3GC-R as a predictive and/or confirmatory test for ESBL and AmpC activity in clinical and veterinary Enterobacteriaceae isolates. The test was highly reliable in the prediction of cefotaxime and cefpodoxime resistance, but there was no correlation with ceftazidime and piperacillin/tazobactam minimal inhibitory concentrations...
2016: PloS One
https://www.readbyqxmd.com/read/27442885/investigation-of-molecular-interaction-between-cefpodoxime-acid-and-human-mixtard-insulin-by-ultrasonic-and-spectral-methods
#19
T Ganesh, V Kannappan, M G Mohamed Kamil, R Kumar
This paper deals with the extensive investigation of molecular interaction between third generation cephalosporin antibiotic, Cefpodoxime Acid (CA) and Human Mixtard Insulin (HMI) in an aqueous medium through ultrasonic, dilute solution viscometric (DSV) and spectral [UV-vis, Attenuated total reflection (ATR)-FT IR] methods at various blend compositions of the drug and insulin at three different (303K, 310K and 313K) temperatures. This is an attempt to unravel the possibility of drug induced hypoglycemic effect...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27436461/emergence-of-ciprofloxacin-resistant-extended-spectrum-%C3%AE-lactamase-producing-enteric-bacteria-in-hospital-wastewater-and-clinical-sources
#20
Meenu Maheshwari, Nawar Hadi Yaser, Suraiya Naz, Mansha Fatima, Iqbal Ahmad
This study aimed to evaluate the incidence of ciprofloxacin-resistant extended-spectrum β-lactamase (ESBL)-producing enteric bacteria in hospital wastewater and clinical sources. Enteric bacteria, mainly Escherichia coli, were isolated from clinical sources (urinary tract and gastrointestinal tract infections; 80 isolates) and hospital wastewater (103 isolates). The antibiotic resistance profile and ESBL production of the isolates were investigated by disc diffusion assay and combined disc diffusion test, respectively...
June 2016: Journal of Global Antimicrobial Resistance
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