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Ilaprazole

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https://www.readbyqxmd.com/read/27605258/a-randomized-double-blind-active-controlled-multi-center-study-of-ilaprazole-in-the-treatment-of-reflux-esophagitis
#1
Yan Xue, Xianghong Qin, Liya Zhou, Sanren Lin, Ling Wang, Haitang Hu, Jielai Xia
BACKGROUND AND OBJECTIVE: Proton pump inhibitors (PPIs) are the main drugs for the treatment of reflux esophagitis. Previous studies have indicated ilaprazole to be safer and more effective in treating duodenal ulcers as compared with omeprazole. Being a novel PPI, ilaprazole may be used in the treatment of reflux esophagitis. The purpose of this study was to evaluate the safety and efficacy of ilaprazole tablets in the treatment of reflux esophagitis. METHODS: This study used a randomized, double-blind, multi-center, active-comparison design...
September 7, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27598861/ilaprazole-for-the-treatment-of-gastro-esophageal-reflux
#2
Edoardo Savarino, Andrea Ottonello, Irene Martinucci, Pietro Dulbecco, Vincenzo Savarino
INTRODUCTION: Despite the undoubted benefit of proton pump inhibitors (PPIs), they have several shortcomings, such as a slow onset of action and a remarkable inter-individual variability, that limit the complete success of these drugs. Recently, a new PPI, ilaprazole, has been developed and used in GERD patients. AREAS COVERED: The present review provides an update on the following points: current knowledge of GERD mechanisms; limitations of actual therapies; pharmacokinetic profile and metabolism of ilaprazole; initial studies on the therapeutic efficacy of ilaprazole in GERD...
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27585842/esophageal-acidification-during-nocturnal-acid-breakthrough-with-ilaprazole-versus-omeprazole-in-gastroesophageal-reflux-disease
#3
Arun Karyampudi, Uday C Ghoshal, Rajan Singh, Abhai Verma, Asha Misra, Vivek A Saraswat
Background/Aims: Though nocturnal acid-breakthrough (NAB) is common in gastroesophageal reflux disease (GERD) patients, its clinical importance results from esophageal acidification, which has been shown to be uncommon. Ilaprazole, a long-acting proton pump inhibitor, may cause NAB infrequently. Accordingly, we studied prospectively, (1) frequency and degree of esophageal acidification during NAB, and (2) frequency and severity of NAB while on ilaprazole versus omeprazole. Methods: Fifty-eight consecutive patients with GERD on once daily ilaprazole, 10 mg (n = 28) or omeprazole, 20 mg (n = 30) for > one month underwent 24-hour impedance-pH monitoring prospectively...
September 1, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27413365/high-dose-ilaprazole-amoxicillin-as-first-line-regimen-for-helicobacter-pylori-infection-in-korea
#4
WonGun Kwack, YunJeong Lim, ChiYeon Lim, David Y Graham
Objective. The eradication rate of Helicobacter pylori (H. pylori) following standard triple therapy has declined over the past few decades. This study has determined whether high dose dual therapy (PPI and amoxicillin) is adequate for eradicating H. pylori in Korea. Methods. This was an open-labeled study of H. pylori infected treatment-naive patients. Subjects received dual therapy for 14 days: ilaprazole 40 mg tablets given twice a day and amoxicillin 750 mg tablets given 4 times a day. At the end of the therapy, the subjects visited the clinic to confirm compliance and monitor for any side effects...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27223846/modeling-the-cost-effectiveness-of-ilaprazole-versus-omeprazole-for-the-treatment-of-newly-diagnosed-duodenal-ulcer-patients-in-china
#5
J W Xuan, R L Song, G X Xu, W Q Lu, Y J Lu, Z Liu
OBJECTIVES: To evaluate the cost-effectiveness of 10 mg ilaprazole once-daily vs 20 mg omeprazole once-daily to treat newly-diagnosed duodenal ulcer patients in China. METHODS: A decision tree model was constructed and the treatment impact was projected up to 1 year. The CYP2C19 polymorphism distribution in the Chinese population, the respective cure rates in the CYP2C19 genotype sub-groups, the impact of Duodenal Ulcer (DU) on utility value and drug-related side-effect data were obtained from the literature...
June 10, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27067231/pharmacokinetics-pharmacodynamics-and-safety-of-multiple-infusion-ilaprazole-in-healthy-chinese-subjects
#6
Hongyun Wang, Liwei Lang, Ning Ou, Ruihua Shi, Haitang Hu, Pei Hu, Ji Jiang
BACKGROUND AND OBJECTIVES: Ilaprazole is a novel proton pump inhibitor that provides effective and long lasting inhibition of intragastric acid secretion. The objectives of this study were to investigate the pharmacokinetics, pharmacodynamics, and safety of intravenous ilaprazole after multiple administrations in healthy Chinese subjects. METHODS: This was an open-label and multiple-dose clinical study. Ten healthy Chinese subjects received 10 mg ilaprazole infusion once daily for 5 days...
June 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27000074/stereoselective-pharmacodynamics-and-pharmacokinetics-of-proton-pump-inhibitors
#7
Zhi-Cheng Yang, Feng Yu, Yong-Qing Wang, Ji-Fu Wei
Proton pump inhibitors (PPIs) are a group of gastric acid suppressing drugs, that are strong and long-lasting inhibitors of the proton pump (referred to as acid pump antagonists). They work by irreversibly blocking the H+/K+ ATPase. PPIs are used to treat peptic ulcer disease, gastroesophageal reflux disease, nonsteroidal anti-inflammatory drug-induced gastrointestinal lesions, and Zollinger-Ellison syndrome. The structure of PPIs are similar, they all have a similar core with a sulphur atom chiral center combined with different substituent groups...
March 22, 2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/26998954/pharmacokinetics-and-pharmacodynamics-of-intravenous-ilaprazole-in-healthy-subjects-after-single-ascending-doses
#8
Hongyun Wang, Ning Ou, Liwei Lang, Ruihua Shi, Pei Hu, Ji Jiang
1. Ilaprazole is a novel proton pump inhibitor and this is the first study to investigate the pharmacokinetics, pharmacodynamics and safety of intravenous ilaprazole in healthy volunteers. 2. In this open-label, single-dose, randomized and four-period crossover study, 16 healthy Chinese subjects received ilaprazole 5, 10 or 20 mg intravenously, or 10 mg orally. Serial blood and urine samples were collected and intragastric pH was recorded within 24 h. The percentage time of intragastric pH > 6 was the major index...
March 21, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/26533511/modeling-the-cost-effectiveness-of-ilaprazole-vs-omeprazole-for-the-treatment-of-newly-diagnosed-duodenal-ulcer-patients-in-china
#9
Y J Lu, G X Xu, W Q Lu, Z Liu, Song Rl, J Xuan
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26034367/modified-sequential-therapy-vs-quadruple-therapy-as-initial-therapy-in-patients-with-helicobacter-infection
#10
RANDOMIZED CONTROLLED TRIAL
Xiao-Min Liao, Gao-Hui Nong, Mei-Zu Chen, Xue-Ping Huang, Yun-Yan Cong, Yi-Ying Huang, Bai-He Wu, Jin-Qi Wei
AIM: To evaluate the efficacy and safety of modified sequential therapy and to compare modified sequential therapy with standard quadruple therapy for Helicobacter pylori (H. pylori) eradication. METHODS: In total, 200 consecutive patients who were diagnosed with H. pylori-infected chronic gastritis by electronic endoscopy and rapid urease testing from December 2012 to October 2013 were enrolled in this study. The patients had not previously received H. pylori eradication treatment, and were randomized into two groups...
May 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25394217/the-association-between-the-use-of-proton-pump-inhibitors-and-the-risk-of-hypomagnesemia-a-systematic-review-and-meta-analysis
#11
REVIEW
Chan Hyuk Park, Eun Hye Kim, Yun Ho Roh, Ha Yan Kim, Sang Kil Lee
BACKGROUND: Although many case reports have described patients with proton pump inhibitor (PPI)-induced hypomagnesemia, the impact of PPI use on hypomagnesemia has not been fully clarified through comparative studies. We aimed to evaluate the association between the use of PPI and the risk of developing hypomagnesemia by conducting a systematic review with meta-analysis. METHODS: We conducted a systematic search of MEDLINE, EMBASE, and the Cochrane Library using the primary keywords "proton pump," "dexlansoprazole," "esomeprazole," "ilaprazole," "lansoprazole," "omeprazole," "pantoprazole," "rabeprazole," "hypomagnesemia," "hypomagnesaemia," and "magnesium...
2014: PloS One
https://www.readbyqxmd.com/read/25041486/the-pharmacokinetics-pharmacodynamics-and-safety-of-oral-doses-of-ilaprazole-10-20-and-40%C3%A2-mg-and-esomeprazole-40%C3%A2-mg-in-healthy-subjects-a-randomised-open-label-crossover-study
#12
RANDOMIZED CONTROLLED TRIAL
J S Shin, J Y Lee, K H Cho, H L Park, M Kukulka, J-T Wu, D Y Kim, S-H Park
BACKGROUND: Ilaprazole, a proton pump inhibitor (PPI) currently in clinical use, may provide improved acid suppression vs. other PPIs. AIM: To compare the pharmacodynamic and pharmacokinetic profiles of ilaprazole and esomeprazole. METHODS: A phase 1, randomised, open-label, single-centre, 4-period crossover study was conducted in 40 healthy volunteers. Ilaprazole 10, 20 or 40 mg or esomeprazole 40 mg was administered once daily for 5 days with ≥5-day washout intervals...
September 2014: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/24803828/efficacy-of-ilaprazole-in-the-treatment-of-duodenal-ulcers-a-meta-analysis
#13
REVIEW
Xi-Qing Ji, Jun-Feng Du, Gang Chen, Guang Chen, Bo Yu
AIM: To compare the efficacy and tolerance of ilaprazole compared with other proton pump inhibitors (PPIs) in the treatment of duodenal ulcer. METHODS: An electronic database search of Medline, Embase, the Cochrane controlled trials register, Web of Science, PubMed, and the Chinese Biomedical Literature Database (updated to July 2013), and manual searches were conducted. A meta-analysis of randomized controlled trials comparing the efficacy and tolerance of ilaprazole and other PPIs in the treatment of duodenal ulcers was performed...
May 7, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/24801687/intravenous-ilaprazole-is-more-potent-than-oral-ilaprazole-against-gastric-lesions-in-rats
#14
Gang Yu, Xin-Qiang Lu, Rui-Bin Su, Ze-Hui Gong, He-Zhi Xie, Hai-Tang Hu, Xue-Mei Hou
BACKGROUND AND AIMS: Ilaprazole is a novel proton pump inhibitor that has been marketed as an oral therapy for acid-related diseases in China and Korea. This study aimed to compare the gastroprotective effects of intravenous and enteral ilaprazole in rat models. METHODS: The rats were divided into 7-8 groups receiving vehicle, esomeprazole, and different doses of intravenous and enteral ilaprazole. The rats were then exposed to indomethacin (30 mg/kg, i.g.), or water-immersion stress and gastric lesions were examined...
October 2014: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/24377157/ilaprazole-is-this-a-superior-proton-pump-inhibitor-for-duodenal-ulcer
#15
REVIEW
N P Bohidar, K Krishna, B K Panda, C Patel
BACKGROUND: Preclinical studies have found ilaprazole to be significantly effective in preventing the development of reflux oesophagitis and gastric secretion in a dose-dependent manner; the drug also has a broad dose range and safety feature. Till date only one clinical study on patients with gastro-oesophageal reflux disease has shown its potency in suppressing gastric acid secretion. OBJECTIVES: To review the published randomized controlled trials (RCTs) assessing the efficacy of ilaprazole in duodenal ulcer (DU) compared to other available proton pump inhibitors (PPI)...
April 2013: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
https://www.readbyqxmd.com/read/23857714/enantiomeric-separation-of-proton-pump-inhibitors-on-new-generation-chiral-columns-using-lc-and-supercritical-fluid-chromatography
#16
Lakshmi Narayana Chennuru, Thirupathi Choppari, Subrahmanyam Duvvuri, Pramod Kumar Dubey
The enantioselectivity of proton pump inhibitors, namely, omeprazole, lansoprazole, rabeprazole, pantoprazole, tenatoprazole, and ilaprazole were studied using new generation chiral packing materials: CHIRALPAK IA, CHIRALPAK IB, and CHIRALPAK IC. Two versatile techniques, HPLC and supercritical fluid chromatography (SFC) were used in this study. CHIRALPAK IC has shown superior selectivity under both LC and SFC conditions, whereas CHIRALPAK IA has shown good selectivity in SFC when compared to LC under primary screening conditions...
September 2013: Journal of Separation Science
https://www.readbyqxmd.com/read/23802731/the-pharmacokinetics-of-ilaprazole-for-gastro-esophageal-reflux-treatment
#17
REVIEW
Nicola de Bortoli, Irene Martinucci, Maria Giacchino, Corrado Blandizzi, Santino Marchi, Vincenzo Savarino, Edoardo Savarino
INTRODUCTION: Approximately 20% of the Western population is affected by gastro-esophageal reflux disease (GERD). To date, proton pump inhibitors (PPIs) represent the mainstay of GERD medical treatment. However, despite their undoubted benefit, about 40% of GERD patients display an inadequate response to these drugs. Recently, a new PPI, ilaprazole , at oral doses of 10 mg has shown higher suppression of gastric acid secretion, more prolonged plasma half-life, and similar safety compared to 20 mg omeprazole...
October 2013: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/23158273/-ilaprazole-based-bismuth-containing-quadruple-regimen-for-the-first-line-treatment-of-helicobacter-pylori-infection-a-multicenter-randomized-controlled-clinical-study
#18
RANDOMIZED CONTROLLED TRIAL
Wen Gao, Hong Cheng, Fu-lian Hu, Nong-hua Lü, Yong Xie, Jian-qiu Sheng, Jian-ming Xu, Ling-xia Zhang, Li Zhang, Ye Chen, Zhen-yu Zhang, Guo-xin Zhang, Mei-hua Cui, Gui-bin Yang, Heng-jun Gao, Li Yang
OBJECTIVE: To explore the effects of 7-day quadruple regimen as the first-line therapy strategy for Helicobacter pylori(H. pylori)infection and compare the eradication rate of ilaprazole versus esoprazole-based regimen. METHODS: A total of 440 patients with H. pylori infection, who had never received H. pylori eradication treatment, were enrolled from 10 domestic hospitals from October 2010 to July 2011. Diagnosed as chronic gastritis or duodenal ulcer according to their endoscopic examination results, they were randomized into ilaprazole and(or) esoprazole-based bismuth-containing quadruple regimen group with amoxicillin and clarithromycin (n = 110 each)...
August 14, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/22934406/-determination-of-ilaprazole-in-beagle-plasma-and-its-pharmaeokineties-by-high-performance-liquid-chromatography-mass-spectrometry
#19
Lijun Zhou, Jinglai Li, Xiaoying Wang, Jianzhong Qiao, Zhenqing Zhang
A sensitive, simple and specific high performance liquid chromatography-electro spray ionization mass spectrometry method was developed for the determination of ilaprazole in the plasma of beagles administered via i.v. bolus doses of ilaprazole. The procedure employed buspirone as the internal standard and a simple protein precipitation step. The separation was achieved using a C18 column (100 mm x 2.1 mm, 5 microm) with a mobile phase consisting of water-methanol-acetonitrile (69:8:23, v/v/v) containing 0...
May 2012: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/22820908/pharmacokinetic-interactions-between-ilaprazole-and-clarithromycin-following-ilaprazole-clarithromycin-and-amoxicillin-triple-therapy
#20
RANDOMIZED CONTROLLED TRIAL
Shan Cao, Gan Zhou, Dong-sheng Ou-Yang, Hui-zi Wu, Kui Xiao, Yao Chen, Dong Guo, Lan Fan, Zhi-rong Tan, Hai-tang Hu, Xiang-hong Qin, Hong-hao Zhou, Wei Zhang
AIM: To investigate the drug interactions between ilaprazole, a new proton pump inhibitor, and clarithromycin following ilaprazole, clarithromycin and amoxicillin combination therapy. METHODS: Twelve healthy Chinese volunteers were recruited in a randomized, open-label, 3-period crossover study. All subjects were administered ilaprazole (5 mg), clarithromycin (500 mg) or a triple therapy, including ilaprazole (5 mg), clarithromycin (500 mg) and amoxicillin (1 g), twice daily for 6 consecutive days...
August 2012: Acta Pharmacologica Sinica
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