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https://www.readbyqxmd.com/read/27796039/biocompatibility-of-on-command-dissolvable-tympanostomy-tube-in-the-rat-model
#1
Johnny P Mai, Matthieu Dumont, Christopher Rossi, Kevin Cleary, Joshua Wiedermann, Brian K Reilly
OBJECTIVES/HYPOTHESIS: A prototype tympanostomy tube, composed of polybutyl/methyl methacrylate-co-dimethyl amino ethyl methacrylate (PBM), was tested to 1) evaluate the effect of PBM tubes on rat dermis as a corollary for biocompatibility and (2) to observe the efficacy of dissolution with isopropyl alcohol (iPrOH) and ethanol (EtOH). STUDY DESIGN: Original animal experiment and bench testing. METHODS: A two-part study was conducted to assess biocompatible substance with inducible dissolvability as a critical characteristic for a newly engineered tympanostomy tube...
October 31, 2016: Laryngoscope
https://www.readbyqxmd.com/read/26361383/bilateral-bloody-otorrhagia-after-robotic-assisted-laparoscopic-prostatectomy
#2
William Scott Jones, Jerome M Klafta
Bloody otorrhagia in the perioperative period is an uncommon event. We present a case of bilateral bloody otorrhagia after uncomplicated robotic-assisted laparoscopic prostatectomy in a 66-year-old man. Anesthetic management was unremarkable. No symptoms were noted by the patient. Postoperative otolaryngology evaluation revealed bilateral ear canal hematomas with intact tympanic membranes. The patient was discharged with Ciprodex ear drops on postoperative day 1. One-month otolaryngology follow-up revealed no long-term sequelae...
September 15, 2015: A & A Case Reports
https://www.readbyqxmd.com/read/25001062/in-vitro-efficacy-of-n-acetylcysteine-on-bacteria-associated-with-chronic-suppurative-otitis-media
#3
Jane Lea, Anne Elizabeth Conlin, Inna Sekirov, Veronica Restelli, Komathi G Ayakar, LeeAnn Turnbull, Patrick Doyle, Michael Noble, Robert Rennie, William E Schreiber, Brian D Westerberg
BACKGROUND: The safety and efficacy of Ciprodex® has been demonstrated for treatment of chronic suppurative otitis media (CSOM). However, symptoms fail to resolve in 9-15% of patients. The objective of this study is to evaluate the efficacy of N-acetylcysteine (NAC) on S. aureus, and planktonic and sessile (biofilm forming) P. aeruginosa in vitro using clinical isolates from patients with CSOM. METHODS: 1) Stability was assessed using liquid chromatography-mass spectrometry for each component in a prepared mixture of Ciprodex® and NAC over 15 days...
2014: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/24518407/oto-201-nonclinical-assessment-of-a-sustained-release-ciprofloxacin-hydrogel-for-the-treatment-of-otitis-media
#4
Xiaobo Wang, Rayne Fernandez, Natalia Tsivkovskaia, Anne Harrop-Jones, Huiying J Hou, Luis Dellamary, David F Dolan, Richard A Altschuler, Carl LeBel, Fabrice Piu
HYPOTHESIS: OTO-201 can provide sustained release to the middle ear and effectively treat otitis media, when compared with FDA-approved ciprofloxacin otic drop formulations. BACKGROUND: There is an unmet medical need for antibiotic therapy that can provide a full course of treatment from a single administration by an otolaryngologist at the time of tympanostomy tube placement, obviating the need for twice daily multiday treatment with short-acting otic drops. METHODS: Studies in guinea pigs and chinchillas were conducted...
March 2014: Otology & Neurotology
https://www.readbyqxmd.com/read/19013865/ciprofloxacin-0-3-dexamethasone-0-1-topical-drops-for-the-management-of-otic-infections
#5
Peter S Roland, Michael Wall
The American Academy of Otolaryngology-Head and Neck Surgery has recommended that, where possible, infections of the external auditory canal and middle ear be treated with topical preparations. The advantages of topical therapy include i) excellent efficacy; ii) decreased risk of systemic side effects; iii) less likelihood of selecting for resistant strains of microorganisms; and iv) lack of potential for ototoxicity. One advantage of topical therapy arises as a consequence of a very high concentration of antibiotic in topical preparations reaching the site of infection...
December 2008: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/18035427/pharmacokinetics-of-ciprodex-otic-in-pediatric-and-adolescent-patients
#6
RANDOMIZED CONTROLLED TRIAL
Zorik Spektor, Mark C Jasek, Dan Jasheway, David C Dahlin, David J Kay, Ron Mitchell, Robert Faulkner, G Michael Wall
OBJECTIVE: Describe the pharmacokinetics of ciprofloxacin and dexamethasone after administration of CIPRODEX Otic Suspension (CIP/DEX) into the middle ears of children. DESIGN: Open-label, single-dose, pharmacokinetic studies, administering four drops of CIP/DEX instilled into each middle ear through the tympanostomy tubes immediately following tube placement. Blood was collected for 6h and analyzed for ciprofloxacin and dexamethasone concentrations using a validated liquid chromatography and tandem mass spectrometry (LC/MS/MS) method...
January 2008: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/17898673/n-acetylcysteine-as-an-adjunct-for-refractory-ear-infections
#7
Won-Taek Choe, Michael T Murray, Katrina R Stidham, Joseph B Roberson
OBJECTIVE: To analyze the efficacy of Ciprodex otic augmented with N-acetylcysteine (NAC) against difficult ear infections. SUBJECTS: Subjects were selected with at least 1 month of continuous otorrhea despite at least 3 distinct medical or surgical treatments. INTERVENTIONS: Subjects received Ciprodex otic augmented with 0.5 or 2% NAC using standard dosing schemes. MAIN OUTCOME MEASURES: Serial audiometry and cessation of otorrhea by both history and binocular microscopy...
December 2007: Otology & Neurotology
https://www.readbyqxmd.com/read/17565934/effect-of-ciprodex-on-graft-healing-in-tympanoplasty
#8
Ashley Starkweather, Rick A Friedman
The present study was conducted to evaluate whether the administration of ciprofloxacin 0.3%/dexamethasone 0.1% (Ciprodex)-soaked gelfoam during tympanoplasty has adverse effects on graft healing. Records of patients who had undergone tympanoplasty with Ciprodex-soaked gelfoam packing placed in the middle and external ear canal were reviewed. The time to heal for each patient and the number of postoperative perforations/complications were recorded. Sixty-four charts met the inclusion criteria. Most procedures were primary type I tympanoplasties with temporalis fascia grafts...
March 2007: Advances in Therapy
https://www.readbyqxmd.com/read/17316832/ciprofloxacin-dexamethasone-drops-decrease-the-incidence-of-physician-and-patient-outcomes-of-otorrhea-after-tube-placement
#9
RANDOMIZED CONTROLLED TRIAL
William Giles, Joseph Dohar, Kenneth Iverson, Paul Cockrum, Frank Hill, Naomi Hill
OBJECTIVE: To evaluate ciprofloxacin 0.3%/dexamethasone 0.1% (CIPRODEX, Alcon, Ft. Worth, TX) for the prevention of early post-operative otorrhea following TT placement. METHODS: This was a single-center, randomized, evaluator-blinded, parallel-group study. Two hundred children undergoing bilateral TT placement were categorized as having unilateral ("wet/dry"), bilateral ("wet/wet"), or no ("dry/dry") effusion at the time of surgery. All patients received Ciprodex or no treatment for 5 days post-operatively and returned at 2 weeks...
May 2007: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/16890085/topical-otic-antibiotics-clinical-cochlear-ototoxicity-and-cost-consideration
#10
Leonard P Berenholz, John M Burkey, Tonia L Farmer, William H Lippy
OBJECTIVE: Determine the incidence of clinical cochlear ototoxicity in routine use of Cortisporin after ventilation tube placement. Cost differential between use of Cortisporin and fluoroquinolone agents was evaluated. METHODS: A retrospective review of 500 patients was performed. Cortisporin otic suspension was used for 5 days following ventilation tube insertion. RESULTS: Testing following surgery indicated a sensorineural hearing loss (SNHL) in 19 (2...
August 2006: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/16880248/topical-ciprofloxacin-dexamethasone-superior-to-oral-amoxicillin-clavulanic-acid-in-acute-otitis-media-with-otorrhea-through-tympanostomy-tubes
#11
RANDOMIZED CONTROLLED TRIAL
Joseph Dohar, William Giles, Peter Roland, Nadim Bikhazi, Sean Carroll, Roderick Moe, Bradley Reese, Sheryl Dupre, Michael Wall, David Stroman, Celeste McLean, Krista Crenshaw
OBJECTIVE: This study was a comparison of topical ciprofloxacin/dexamethasone otic suspension to oral amoxicillin/clavulanic acid suspension in children with acute otitis media with otorrhea through tympanostomy tubes. METHODS: This was a randomized, observer-masked, parallel-group, multicenter trial of topical ciprofloxacin/dexamethasone otic suspension versus amoxicillin/clavulanic acid suspension in 80 children aged 6 months to 12 years with acute otitis media with otorrhea through tympanostomy tubes of < or = 3 weeks' duration and visible otorrhea...
September 2006: Pediatrics
https://www.readbyqxmd.com/read/15837902/effect-of-corticosteroid-antibiotic-agents-on-granulation-tissue-in-a-murine-model
#12
COMPARATIVE STUDY
Steven E Sobol, Sundeep Keswani, Jignesh K Parvadia, Timothy Crombleholme, William P Potsic
OBJECTIVE: To compare the effects of 3 commonly used ototopical corticosteroid-antibiotic agents, currently available for use in the treatment of inflammatory conditions of the external and middle ear, on granulation tissue in an established murine model of wound healing. SUBJECTS: Twelve C57/BL6J mice. DESIGN: Eight-millimeter wounds, created bilaterally on the dorsum of the mice, were treated with combinations of 0.3% ciprofloxacin and 0...
April 2005: Archives of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/15324520/efficacy-and-safety-of-topical-ciprofloxacin-dexamethasone-versus-neomycin-polymyxin-b-hydrocortisone-for-otitis-externa
#13
RANDOMIZED CONTROLLED TRIAL
Peter S Roland, Francis D Pien, Craig C Schultz, Dan C Henry, Peter J Conroy, G Michael Wall, Rekha Garadi, Sheryl J Dupre, Susan L Potts, L Gail Hogg, David W Stroman et al.
OBJECTIVES: To compare the efficacy and safety of ciprofloxacin 0.3%/dexamethasone 0.1% (CIP/DEX) otic suspension with that of neomycin 0.35%/polymyxin B 10,000 IU/mL/hydrocortisone 1.0% (N/P/H) otic suspension in patients with acute otitis externa (AOE). STUDY DESIGN: Randomized, observer-masked, parallel-group, multicenter study. Patients were randomized to 7 days treatment with either CIP/DEX 3-4 drops twice daily or N/P/H 3-4 drops three times daily. POPULATION: Patients of either sex and older than 1 year, with a clinical diagnosis of mild, moderate, or severe AOE and intact tympanic membranes were recruited to participate...
August 2004: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/15195060/topical-ciprofloxacin-dexamethasone-otic-suspension-is-superior-to-ofloxacin-otic-solution-in-the-treatment-of-granulation-tissue-in-children-with-acute-otitis-media-with-otorrhea-through-tympanostomy-tubes
#14
RANDOMIZED CONTROLLED TRIAL
Peter S Roland, Joseph E Dohar, Brent J Lanier, Robert Hekkenburg, Edward M Lane, Peter J Conroy, G Michael Wall, Sheryl J Dupre, Susan L Potts
OBJECTIVE: Comparison of topical ciprofloxacin/dexamethasone otic suspension (CIP/DEX) to ofloxacin otic solution (OFL) for treatment of granulation tissue in children with AOMT. STUDY DESIGN: 599 children aged >/=6 months to 12 years with AOMT of up to 3 weeks' duration were enrolled. Patients received either CIP/DEX 4 drops twice daily for 7 days or OFL 5 drops twice daily for 10 days. Granulation tissue severity was graded at clinic visits on days 1, 3, 11, and 18...
June 2004: Otolaryngology—Head and Neck Surgery
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